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Aliases for RPL29 Gene

Aliases for RPL29 Gene

  • Ribosomal Protein L29 2 3 5
  • Cell Surface Heparin-Binding Protein HIP 2 3 4
  • Heparin/Heparan Sulfate-Interacting Protein 2 3
  • Heparin/Heparan Sulfate-Binding Protein 2 3
  • 60S Ribosomal Protein L29 2 3
  • HP/HS-Interacting Protein 2 3
  • Ribosomal Protein L29 Pseudogene 10 2
  • Ribosomal Protein YL43 Homologue 3
  • RPL29_3_370 3
  • HUMRPL29 3
  • RPL29P10 3
  • HIP 3
  • L29 3

External Ids for RPL29 Gene

Previous HGNC Symbols for RPL29 Gene

  • RPL29P10

Previous GeneCards Identifiers for RPL29 Gene

  • GC03M051120
  • GC03M051280
  • GC03M051879
  • GC03M051986
  • GC03M052002
  • GC03M052028

Summaries for RPL29 Gene

Entrez Gene Summary for RPL29 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin. Although this gene was previously reported to map to 3q29-qter, it is believed that it is located at 3p21.3-p21.2. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL29 Gene

RPL29 (Ribosomal Protein L29) is a Protein Coding gene. Diseases associated with RPL29 include Conotruncal Heart Malformations. Among its related pathways are Viral mRNA Translation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL29 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL29 Gene

Genomics for RPL29 Gene

Regulatory Elements for RPL29 Gene

Enhancers for RPL29 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RPL29 on UCSC Golden Path with GeneCards custom track

Promoters for RPL29 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPL29 Gene

Chromosome:
3
Start:
51,993,600 bp from pter
End:
51,995,942 bp from pter
Size:
2,343 bases
Orientation:
Minus strand

Genomic View for RPL29 Gene

Genes around RPL29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL29 Gene

Proteins for RPL29 Gene

  • Protein details for RPL29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47914-RL29_HUMAN
    Recommended name:
    60S ribosomal protein L29
    Protein Accession:
    P47914
    Secondary Accessions:
    • A8K0H3
    • B2R4M8
    • Q6IPY3

    Protein attributes for RPL29 Gene

    Size:
    159 amino acids
    Molecular mass:
    17752 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL29 Gene

neXtProt entry for RPL29 Gene

Post-translational modifications for RPL29 Gene

  • Ubiquitination at Lys 38, Lys 56, Lys 63, and Lys 73
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL29 Gene

Domains & Families for RPL29 Gene

Gene Families for RPL29 Gene

Protein Domains for RPL29 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RPL29 Gene

Graphical View of Domain Structure for InterPro Entry

P47914

UniProtKB/Swiss-Prot:

RL29_HUMAN :
  • Belongs to the ribosomal protein L29e family.
Family:
  • Belongs to the ribosomal protein L29e family.
genes like me logo Genes that share domains with RPL29: view

Function for RPL29 Gene

Molecular function for RPL29 Gene

GENATLAS Biochemistry:
60S ribosomal protein L29,identical to a cell surface heparin/heparan (HP/HS) binding protein

Gene Ontology (GO) - Molecular Function for RPL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8597591
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0008201 heparin binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with RPL29: view

Phenotypes for RPL29 Gene

genes like me logo Genes that share phenotypes with RPL29: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL29 Gene

Localization for RPL29 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL29 Gene COMPARTMENTS Subcellular localization image for RPL29 gene
Compartment Confidence
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for RPL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
genes like me logo Genes that share ontologies with RPL29: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL29 Gene

Pathways & Interactions for RPL29 Gene

genes like me logo Genes that share pathways with RPL29: view

Pathways by source for RPL29 Gene

1 KEGG pathway for RPL29 Gene
1 GeneGo (Thomson Reuters) pathway for RPL29 Gene

Gene Ontology (GO) - Biological Process for RPL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL29: view

No data available for SIGNOR curated interactions for RPL29 Gene

Drugs & Compounds for RPL29 Gene

(4) Drugs for RPL29 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 779,250

(3) Additional Compounds for RPL29 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPL29: view

Transcripts for RPL29 Gene

Unigene Clusters for RPL29 Gene

Ribosomal protein L29:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL29 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4
SP1:
SP2: - -
SP3:

Relevant External Links for RPL29 Gene

GeneLoc Exon Structure for
RPL29
ECgene alternative splicing isoforms for
RPL29

Expression for RPL29 Gene

mRNA expression in normal human tissues for RPL29 Gene

Protein differential expression in normal tissues from HIPED for RPL29 Gene

This gene is overexpressed in Stomach (9.9) and Tlymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RPL29 Gene



Protein tissue co-expression partners for RPL29 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL29 Gene:

RPL29

SOURCE GeneReport for Unigene cluster for RPL29 Gene:

Hs.425125
genes like me logo Genes that share expression patterns with RPL29: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL29 Gene

Orthologs for RPL29 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL29 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPL29 34
  • 91.34 (n)
  • 93.7 (a)
RPL29 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL29 34
  • 92.78 (n)
  • 97.5 (a)
-- 35
  • 46 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RPL29 34
  • 99.57 (n)
  • 99.35 (a)
RPL29 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 48 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm4889 35
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves RPL29 34
  • 87.3 (n)
  • 98.41 (a)
RPL29 35
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL29 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl29 34
  • 84.66 (n)
  • 96.83 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8224 34
zebrafish
(Danio rerio)
Actinopterygii RPL29 35
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RpL29 35
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpl-29 35
  • 55 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL29 35
  • 66 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os.1082 34
wheat
(Triticum aestivum)
Liliopsida Ta.12895 34
corn
(Zea mays)
Liliopsida Zm.6182 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4934 35
  • 71 (a)
OneToOne
Species where no ortholog for RPL29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL29 Gene

ENSEMBL:
Gene Tree for RPL29 (if available)
TreeFam:
Gene Tree for RPL29 (if available)

Paralogs for RPL29 Gene

genes like me logo Genes that share paralogs with RPL29: view

No data available for Paralogs for RPL29 Gene

Variants for RPL29 Gene

Sequence variations from dbSNP and Humsavar for RPL29 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1062406 -- 51,993,754(-) CTTCA(A/G)AGTAG reference, missense
rs1062408 -- 51,993,744(-) GATAT(C/T)TCTGC utr-variant-3-prime
rs1062409 -- 51,993,742(-) TATCT(C/T)TGCCA utr-variant-3-prime
rs1065689 -- 51,993,956(-) AGCCG(C/T)AAGCT reference, synonymous-codon
rs1065748 -- 51,993,923(-) CACCC(C/T)AAGCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RPL29 Gene

Variant ID Type Subtype PubMed ID
nsv1003453 CNV gain 25217958
nsv508922 CNV insertion 20534489
nsv519445 CNV gain+loss 19592680
nsv520211 CNV gain 19592680
nsv954857 CNV deletion 24416366
nsv963318 CNV duplication 23825009

Variation tolerance for RPL29 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.41; 81.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL29 Gene

Disorders for RPL29 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL29 Gene - From: DISEASES

Disorder Aliases PubMed IDs
conotruncal heart malformations
  • double-outlet right ventricle
- elite association - COSMIC cancer census association via MalaCards
Search RPL29 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPL29

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL29
genes like me logo Genes that share disorders with RPL29: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL29 Gene

Publications for RPL29 Gene

  1. A novel cDNA encoding a human homologue of ribosomal protein L29. (PMID: 8597591) Law P.T. … Waye M.M.Y. (Biochim. Biophys. Acta 1996) 2 3 4 22 65
  2. cDNA cloning and expression of HIP, a novel cell surface heparan sulfate/heparin-binding protein of human uterine epithelial cells and cell lines. (PMID: 8662616) Liu S. … Carson D.D. (J. Biol. Chem. 1996) 3 4 22 65
  3. Repression of HIP/RPL29 expression induces differentiation in colon cancer cells. (PMID: 16475173) Liu J.J. … Hooi S.C. (J. Cell. Physiol. 2006) 3 22 65
  4. Analysis of eluted peptides from type 1 diabetes-susceptible HLA class II molecules identified novel islet protein, heparin/heparan sulfate-interacting protein. (PMID: 15721314) Nakanishi K. … Matsushita H. (Biochem. Biophys. Res. Commun. 2005) 3 22 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for RPL29 Gene

Sources for RPL29 Gene

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