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Aliases for RPL29 Gene

Aliases for RPL29 Gene

  • Ribosomal Protein L29 2 3
  • Cell Surface Heparin-Binding Protein HIP 2 3 4
  • Heparin/Heparan Sulfate-Interacting Protein 2 3
  • Heparin/Heparan Sulfate-Binding Protein 2 3
  • HP/HS-Interacting Protein 2 3
  • Ribosomal Protein L29 Pseudogene 10 2
  • Ribosomal Protein YL43 Homologue 3
  • 60S Ribosomal Protein L29 2
  • RPL29_3_370 3
  • HUMRPL29 3
  • RPL29P10 3
  • HIP 3
  • L29 3

External Ids for RPL29 Gene

Previous HGNC Symbols for RPL29 Gene

  • RPL29P10

Previous GeneCards Identifiers for RPL29 Gene

  • GC03M051120
  • GC03M051280
  • GC03M051879
  • GC03M051986
  • GC03M052002
  • GC03M052028

Summaries for RPL29 Gene

Entrez Gene Summary for RPL29 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin. Although this gene was previously reported to map to 3q29-qter, it is believed that it is located at 3p21.3-p21.2. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL29 Gene

RPL29 (Ribosomal Protein L29) is a Protein Coding gene. Diseases associated with RPL29 include conotruncal heart malformations. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL29 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL29 Gene

Genomics for RPL29 Gene

Regulatory Elements for RPL29 Gene

Genomic Location for RPL29 Gene

51,993,600 bp from pter
51,995,942 bp from pter
2,343 bases
Minus strand

Genomic View for RPL29 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL29 Gene

Proteins for RPL29 Gene

  • Protein details for RPL29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L29
    Protein Accession:
    Secondary Accessions:
    • A8K0H3
    • B2R4M8
    • Q6IPY3

    Protein attributes for RPL29 Gene

    159 amino acids
    Molecular mass:
    17752 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL29 Gene

neXtProt entry for RPL29 Gene

Proteomics data for RPL29 Gene at MOPED

Post-translational modifications for RPL29 Gene

  • Ubiquitination at Lys 38, Lys 56, Lys 63, and Lys 73
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL29 Gene

Domains & Families for RPL29 Gene

Gene Families for RPL29 Gene

Protein Domains for RPL29 Gene


Suggested Antigen Peptide Sequences for RPL29 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L29e family.
  • Belongs to the ribosomal protein L29e family.
genes like me logo Genes that share domains with RPL29: view

Function for RPL29 Gene

Molecular function for RPL29 Gene

GENATLAS Biochemistry:
60S ribosomal protein L29,identical to a cell surface heparin/heparan (HP/HS) binding protein

Gene Ontology (GO) - Molecular Function for RPL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8597591
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0008201 heparin binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL29: view
genes like me logo Genes that share phenotypes with RPL29: view

Animal Models for RPL29 Gene

MGI Knock Outs for RPL29:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL29

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RPL29 Gene

Localization for RPL29 Gene

Subcellular locations from

Jensen Localization Image for RPL29 Gene COMPARTMENTS Subcellular localization image for RPL29 gene
Compartment Confidence
cytosol 5
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
genes like me logo Genes that share ontologies with RPL29: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL29 Gene

Pathways & Interactions for RPL29 Gene

genes like me logo Genes that share pathways with RPL29: view

Pathways by source for RPL29 Gene

1 BioSystems pathway for RPL29 Gene
1 KEGG pathway for RPL29 Gene
1 GeneGo (Thomson Reuters) pathway for RPL29 Gene

Gene Ontology (GO) - Biological Process for RPL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPL29: view

No data available for SIGNOR curated interactions for RPL29 Gene

Drugs & Compounds for RPL29 Gene

(2) Drugs for RPL29 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 672,226
Hyaluronan Approved Pharma 328

(5) Additional Compounds for RPL29 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chondroitin sulfate
  • Chondritinsulfate
  • Chondritinsulphate
  • Chondroitin 6-sulfate
  • Chondroitin 6-sulphate
  • Chondroitin polysulfate
heparan sulfate
  • alpha-Idosane
  • Heparan N-sulfate
  • Heparan N-sulphate
  • Heparan sulfate
  • Heparan sulphate
keratan sulfate
genes like me logo Genes that share compounds with RPL29: view

Transcripts for RPL29 Gene

Unigene Clusters for RPL29 Gene

Ribosomal protein L29:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL29

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL29 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4
SP2: - -

Relevant External Links for RPL29 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL29 Gene

mRNA expression in normal human tissues for RPL29 Gene

Protein differential expression in normal tissues from HIPED for RPL29 Gene

This gene is overexpressed in Stomach (9.9) and Tlymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RPL29 Gene

SOURCE GeneReport for Unigene cluster for RPL29 Gene Hs.425125

genes like me logo Genes that share expression patterns with RPL29: view

Protein tissue co-expression partners for RPL29 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL29 Gene

Orthologs for RPL29 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL29 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL29 35
  • 91.34 (n)
  • 93.7 (a)
RPL29 36
  • 84 (a)
(Canis familiaris)
Mammalia RPL29 35
  • 92.78 (n)
  • 97.5 (a)
-- 36
  • 46 (a)
-- 36
  • 45 (a)
-- 36
  • 64 (a)
-- 36
  • 78 (a)
(Pan troglodytes)
Mammalia RPL29 35
  • 99.57 (n)
  • 99.35 (a)
RPL29 36
  • 97 (a)
(Mus musculus)
Mammalia Rpl29 16
Gm4889 36
  • 81 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
-- 36
  • 59 (a)
(Gallus gallus)
Aves RPL29 35
  • 87.3 (n)
  • 98.41 (a)
RPL29 36
  • 89 (a)
(Anolis carolinensis)
Reptilia RPL29 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl29 35
  • 84.66 (n)
  • 96.83 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8224 35
(Danio rerio)
Actinopterygii RPL29 36
  • 86 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL29 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea rpl-29 36
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL29 36
  • 66 (a)
(Oryza sativa)
Liliopsida Os.1082 35
(Triticum aestivum)
Liliopsida Ta.12895 35
(Zea mays)
Liliopsida Zm.6182 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4934 36
  • 71 (a)
Species with no ortholog for RPL29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL29 Gene

Gene Tree for RPL29 (if available)
Gene Tree for RPL29 (if available)

Paralogs for RPL29 Gene

genes like me logo Genes that share paralogs with RPL29: view

No data available for Paralogs for RPL29 Gene

Variants for RPL29 Gene

Sequence variations from dbSNP and Humsavar for RPL29 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs323864 -- 51,993,314(-) CTCCC(A/G)GGTTC downstream-variant-500B
rs1062406 -- 51,993,754(-) CTTCA(A/G)AGTAG missense, reference
rs1062408 -- 51,993,744(-) GATAT(C/T)TCTGC utr-variant-3-prime
rs1062409 -- 51,993,742(-) TATCT(C/T)TGCCA utr-variant-3-prime
rs1065689 -- 51,993,956(-) AGCCG(C/T)AAGCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RPL29 Gene

Variant ID Type Subtype PubMed ID
nsv520211 CNV Gain 19592680
nsv508922 CNV Insertion 20534489
nsv876780 CNV Loss 21882294
nsv519445 CNV Gain+Loss 19592680

Variation tolerance for RPL29 Gene

Residual Variation Intolerance Score: 46.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.41; 81.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL29 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL29 Gene

Disorders for RPL29 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL29 Gene - From: DISEASES

Disorder Aliases PubMed IDs
conotruncal heart malformations
  • double-outlet right ventricle
- elite association
Search RPL29 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPL29

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL29: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL29 Gene

Publications for RPL29 Gene

  1. A novel cDNA encoding a human homologue of ribosomal protein L29. (PMID: 8597591) Law P.T. … Waye M.M.Y. (Biochim. Biophys. Acta 1996) 2 23 67
  2. A surface plasmon resonance-based solution affinity assay for heparan sulfate-binding proteins. (PMID: 19034645) Cochran S. … Ferro V. (Glycoconj. J. 2009) 23 67
  3. Modular synthesis of heparan sulfate oligosaccharides for structure-activity relationship studies. (PMID: 19904943) Arungundram S. … Boons G.J. (J. Am. Chem. Soc. 2009) 23 67
  4. Interaction of heparin and heparin-derived oligosaccharides with synthetic peptide analogues of the heparin-binding domain of heparin/heparan sulfate-interacting protein. (PMID: 19747524) Wang J. … Rabenstein D.L. (Biochim. Biophys. Acta 2009) 23 67
  5. Identification of heparin/heparan sulfate interacting protein as a major broad-spectrum antimicrobial protein in lung and small intestine. (PMID: 18299334) Meyer-Hoffert U. … PA1tsep K. (FASEB J. 2008) 23 67

Products for RPL29 Gene

Sources for RPL29 Gene

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