Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RPL28 Gene

protein-coding   GIFtS: 63
GCID: GC19P055897

Ribosomal Protein L28

  See RPL28-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ribosomal Protein L281 2
60S Ribosomal Protein L281 2
L282

External Ids:    HGNC: 103301   Entrez Gene: 61582   Ensembl: ENSG000001081077   OMIM: 6036385   UniProtKB: P467793   

Export aliases for RPL28 gene to outside databases

Previous GC identifers: GC19P056761 GC19P056320 GC19P060571 GC19P060589 GC19P052219


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RPL28 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family
of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers
compared to adjacent normal tissues has been observed, although no correlation between the level of expression
and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are
multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in
multiple transcript variants encoding distinct isoforms.(provided by RefSeq, Oct 2008)

GeneCards Summary for RPL28 Gene:
RPL28 (ribosomal protein L28) is a protein-coding gene. Diseases associated with RPL28 include esophagus squamous cell carcinoma. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

Gene Wiki entry for RPL28 (60S ribosomal protein L28) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL28 gene promoter:
         NF-1   Pax-5   AML1a   STAT5A   HEN1   PPAR-gamma1   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL28 promoter sequence
   Search Chromatin IP Primers for RPL28

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

RPL28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL28 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055897:  view genomic region     (about GC identifiers)

Start:
55,896,713 bp from pter      End:
55,914,612 bp from pter
Size:
17,900 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RL28_HUMAN, P46779 (See protein sequence)
Recommended Name: 60S ribosomal protein L28  
Size: 137 amino acids; 15748 Da
1 PDB 3D structure from and Proteopedia for RPL28:
3J3B (3D)    
Secondary accessions: B2R4A6 B4DEP9 C9JB50 E9PB24 G5E9L2 Q6IAY0 Q96FX1 Q9BWQ0
Alternative splicing: 5 isoforms:  P46779-1   P46779-2   P46779-3   P46779-4   P46779-5   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for RPL28: NX_P46779

Explore proteomics data for RPL28 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys19, Lys22, Lys33, Lys47, Lys58, Lys65, Lys72, Lys101
  • Modification sites at PhosphoSitePlus

  • See RPL28 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_000982.2  NP_001129606.1  NP_001129607.1  NP_001129608.1  NP_001129609.1  

    ENSEMBL proteins: 
     ENSP00000342787   ENSP00000400596   ENSP00000391665   ENSP00000452909   ENSP00000453029  
     ENSP00000452763   ENSP00000453319   ENSP00000453285   ENSP00000453584   ENSP00000401450  
    Reactome Protein details: P46779

    RPL28 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RPL28
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RPL28
    GenScript Custom Purified and Recombinant Proteins Services for RPL28
    Novus Biologicals RPL28 Proteins
    Novus Biologicals RPL28 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPL28

     
    Search eBioscience for Proteins for RPL28 

    RPL28 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RPL28
    OriGene Custom Antibody Services for RPL28
    Novus Biologicals RPL28 Antibodies
    Abcam antibodies for RPL28
    Cloud-Clone Corp. Antibodies for RPL28
    Search ThermoFisher Antibodies for RPL28
    LSBio Antibodies in human, mouse, rat for RPL28

    RPL28 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RPL28
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RPL28
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RPL28
    Cloud-Clone Corp. CLIAs for RPL28
    Search eBioscience for ELISAs for RPL28 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RPL: L ribosomal proteins

    1 InterPro protein domain:
     IPR002672 Ribosomal_L28e

    Graphical View of Domain Structure for InterPro Entry P46779

    ProtoNet protein and cluster: P46779

    1 Blocks protein domain: IPB002672 Ribosomal L28e protein

    UniProtKB/Swiss-Prot: RL28_HUMAN, P46779
    Similarity: Belongs to the ribosomal protein L28e family


    Find genes that share domains with RPL28           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:
         Genatlas biochemistry entry for RPL28:
    60S ribosomal protein L28,15kDa

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS7772601
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RPL28           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RPL28:
     Nuclear 60S biogenesis defects 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL28
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPL28

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPL28
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPL28

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPL28:
    hsa-mir-18a-3p (MIRT040784), hsa-mir-766-3p (MIRT039018), hsa-mir-26b-5p (MIRT029284), hsa-mir-484 (MIRT042206), hsa-mir-128-3p (MIRT021997)

    Block miRNA regulation of human, mouse, rat RPL28 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RPL28:
    hsa-miR-137
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RPL28
    Predesigned siRNA for gene silencing in human, mouse, rat RPL28

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPL28

    Clone
    Products:
         
    OriGene clones in human, mouse for RPL28 (see all 29)
    OriGene ORF clones in mouse, rat for RPL28
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): RPL28 (NM_001136134)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL28
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL28

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RPL28
    Browse ESI BIO Cell Lines and PureStem Progenitors for RPL28 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL28


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion3
    peroxisome2
    chloroplast1
    extracellular1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with RPL28           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RPL28 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    Cytoplasmic Ribosomal Proteins0.60
    Ribosome0.54
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease


    Find genes that share SuperPaths with RPL28           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RPL28
        Cytoplasmic Ribosomal Proteins

    Selected Reactome Pathways for RPL28 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL28):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL28
    Interactions:

        Search GeneGlobe Interaction Network for RPL28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL28 (P467791, 2, 3 ENSP000004014504) via UniProtKB, MINT, STRING, and/or I2D (see all 279)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMEM230Q96A572, 3, ENSP000003413644MINT-65666 I2D: score=4 STRING: ENSP00000341364
    DCCP431461, 3, ENSP000003891404EBI-366357,EBI-1222919 I2D: score=2 STRING: ENSP00000389140
    SMAD4Q134852, 3MINT-61965 I2D: score=3 
    RPL18AQ025432, ENSP000002222474MINT-6489539 MINT-6488590 MINT-6488791 STRING: ENSP00000222247
    RPL4P365782, ENSP000003114304MINT-6489539 MINT-6488590 MINT-6488791 STRING: ENSP00000311430
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    Find genes that share ontologies with RPL28           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL28 (RL28)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RPL28 gene (5 alternative transcripts): 
    NM_000991.4  NM_001136134.1  NM_001136135.1  NM_001136136.1  NM_001136137.1  

    Unigene Cluster for RPL28:

    Ribosomal protein L28
    Hs.652114  [show with all ESTs]
    Unigene Representative Sequence: NM_001136134
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344063(uc010yga.2 uc002qkv.3) ENST00000431533(uc010yfz.2)
    ENST00000428193 ENST00000558815 ENST00000560583 ENST00000560055 ENST00000560881(uc010yfy.1)
    ENST00000559463 ENST00000558131 ENST00000426763(uc010ygb.2) ENST00000558752
    ENST00000458349
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RPL28 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RPL28:
    hsa-miR-137
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RPL28
    Predesigned siRNA for gene silencing in human, mouse, rat RPL28
    Clone
    Products:
         
    OriGene clones in human, mouse for RPL28 (see all 29)
    OriGene ORF clones in mouse, rat for RPL28
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): RPL28 (NM_001136134)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL28
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL28
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RPL28
    OriGene qSTAR qPCR primer pairs in human, mouse for RPL28
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPL28
      QuantiTect SYBR Green Assays in human, mouse, rat RPL28
      QuantiFast Probe-based Assays in human, mouse, rat RPL28

    Additional mRNA sequence: 

    AK025866.1 AK125297.1 AK293736.1 AK311760.1 BC010173.2 BC010182.2 BC011582.1 BC015398.1 
    CR457024.1 HQ013233.1 U14969.1 

    Selected DOTS entries (see all 68):

    DT.100871201  DT.97869722  DT.100852142  DT.92465547  DT.91889315  DT.95361710  DT.95361773  DT.100717482 
    DT.95096765  DT.92465597  DT.75101944  DT.100717518  DT.100717483  DT.121503146  DT.95196937  DT.121503245 
    DT.121503090  DT.102839305  DT.95361833  DT.92465563  DT.100843023  DT.92465544  DT.121503140  DT.436623 

    Selected AceView cDNA sequences (see all 1822):

    AW291527 BU726746 CR609404 BM841799 BF128867 AW327950 BM818014 BM504238 
    BU783183 BM671618 AI833324 AA402966 BM551501 BU069997 AA352725 BI860332 
    BM468860 CA446544 BM822964 AI459629 AI828965 AI688892 BF726247 BU146411 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPL28 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b
    SP1:                                -     -     -                                       
    SP2:                                -     -     -           -     -     -               
    SP3:                                -     -     -                                       
    SP4:                                                                                    
    SP5:                                -     -     -                                       


    ECgene alternative splicing isoforms for RPL28

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RPL28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGCCATCC
    RPL28 Expression
    About this image


    RPL28 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    RPL28 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL28 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.652114
        Custom PCR Arrays for RPL28
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RPL28
    OriGene qSTAR qPCR primer pairs in human, mouse for RPL28
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPL28
    QuantiTect SYBR Green Assays in human, mouse, rat RPL28
    QuantiFast Probe-based Assays in human, mouse, rat RPL28
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RPL28 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl281 , 5 ribosomal protein L281, 5 89.29(n)1
    98.54(a)1
      7 (2.77 cM)5
    199431  NM_009081.21  NP_033107.11 
     47928745 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    72(a)
    52(a)
    many → 1
    many → 1
    GL343279.1(1340204-1347131)
    4(62241517-62241930)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.175232 Xenopus laevis transcribed sequence with strong similarity more 88.11(n)    BX848908.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc662892 similar to ribosomal protein L28 80.18(n)   394036  BC055584.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL281 Ribosomal protein L28 56.49(n)
    46.56(a)
      38397  NM_001169865.2  NP_001163336.1 


    ENSEMBL Gene Tree for RPL28 (if available)
    TreeFam Gene Tree for RPL28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RPL28 gene

    Find genes that share paralogs with RPL28           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RPL28 (see all 7)
    PGOHUM00000239910 PGOHUM00000247130 PGOHUM00000234512 PGOHUM00000246403 PGOHUM00000262147


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RPL28 (see all 229)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1856368081,2
    --52217090(+) TCCATC/TGCTCC 5 -- us2k10--------
    rs1166586171,2
    C,F--52217142(+) CTCCCC/GGCCCT 5 -- us2k11Minor allele frequency- G:0.14WA 118
    rs621281871,2
    C--55897671(+) GCTGCT/CTTAGT 5 -- int12Minor allele frequency- C:0.02NA NS 152
    rs1130834281,2
    C--55897715(+) CCCCGC/GAGCCG 5 -- int10--------
    rs752176371,2
    C,F--55897817(+) TGGGGC/TCCGGA 5 -- int14Minor allele frequency- T:0.00CSA WA NS EU 1587
    rs794461751,2
    C,F--55897864(+) TGACTC/GTGGGT 5 -- int11Minor allele frequency- G:0.03WA 118
    rs2005565051,2
    C--55897889(+) TTCGCA/G/TTGTCT 5 -- int10--------
    rs2000594711,2
    --55897911(+) ATTCAC/GGATGC 5 -- int10--------
    rs1476140771,2
    C,F--55897956(+) TGAAGG/ACCCGC 10 /T /A mis11Minor allele frequency- A:0.00NA 4552
    rs1491225591,2
    F--55897963(+) CCGCAA/GTTCCT 10 N S mis11Minor allele frequency- G:0.00NA 4552

    HapMap Linkage Disequilibrium report for RPL28 (55896713 - 55914612 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RPL28:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4017n71CNV Loss21882294
    nsv912461CNV Loss21882294
    nsv516199CNV Loss19592680
    nsv912463CNV Loss21882294
    nsv912473CNV Loss21882294
    nsv912457CNV Loss21882294
    dgv4016n71CNV Loss21882294
    dgv4020n71CNV Loss21882294
    nsv912460CNV Loss21882294
    nsv470162CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL28
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603638    OMIM disorders: --

    1 disease for RPL28:    
    About MalaCards
    esophagus squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for RPL28:
    Esophagus squamous cell carcinoma

    Find genes that share disorders with RPL28           About GenesLikeMe

    Genetic Association Database (GAD): RPL28
    Human Genome Epidemiology (HuGE) Navigator: RPL28 (1 document)

    Export disorders for RPL28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RPL28 gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with RPL28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PubMed id 7772601)1, 2, 3 Frigerio J.-M.... Iovanna J.L. (Biochim. Biophys. Acta 1995)
    2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (J. Protein Chem. 2003)
    6. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 3 Kenmochi N.... Page D.C. (Genome Res. 1998)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)
    9. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    10. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6158 HGNC: 10330 AceView: RPL28 Ensembl:ENSG00000108107 euGenes: HUgn6158
    ECgene: RPL28 Kegg: 6158 H-InvDB: RPL28

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RPL28 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPL28 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RPL28 gene:
    Search GeneIP for patents involving RPL28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RPL28   OriGene RNAi products in human, mouse, rat for RPL28  
     OriGene qPCR primer pairs and template standards for RPL28   OriGene Protein Over-expression Lysate for RPL28  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RPL28  
     OriGene qSTAR qPCR primer pairs in human, mouse for RPL28   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RPL28   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPL28   OriGene Custom Protein Services for RPL28  

     
     
     Block miRNA regulation of human, mouse, rat RPL28 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RPL28
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL28 Predesigned siRNA for gene silencing in human, mouse, rat RPL28
     QuantiFast Probe-based Assays in human, mouse, rat RPL28 QuantiTect SYBR Green Assays in human, mouse, rat RPL28
     Custom PCR Arrays for RPL28 Search Chromatin IP Primers for RPL28
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPL28  Search GeneGlobe Interaction Network for RPL28
     Regulatory tfbs in RPL28 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RPL28 GenScript cDNA clones with any tag delivered in your preferred vector for RPL28
     GenScript Custom Assay Services for RPL28 GenScript Custom overexpressing Cell Line Services for RPL28
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RPL28 (RL28)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RPL28 antibodies
     RPL28 proteins
     RPL28 lysates
     Antibodies for RPL28
     See all of Abcam's Antibodies, Kits and Proteins for RPL28
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RPL28
     Antibodies for RPL28
     ELISAs for RPL28
     CLIAs for RPL28



     Browse ESI BIO Cell Lines and PureStem Progenitors for RPL28
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL28
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RPL28
     SwitchGear Promoter luciferase reporter plasmids for RPL28
     Search ThermoFisher Antibodies for RPL28
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL28
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL28
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPL28
     LSBio Antibodies in human, mouse, rat for RPL28
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RPL28
      Search eBioscience for proteins for RPL28
      Search eBioscience for elisas for RPL28
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RPL28 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4