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Aliases for RPL28 Gene

Aliases for RPL28 Gene

  • Ribosomal Protein L28 2 3 5
  • 60S Ribosomal Protein L28 2 3
  • L28 3

External Ids for RPL28 Gene

Previous GeneCards Identifiers for RPL28 Gene

  • GC19P056761
  • GC19P056320
  • GC19P060571
  • GC19P060589
  • GC19P055897
  • GC19P052219

Summaries for RPL28 Gene

Entrez Gene Summary for RPL28 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

GeneCards Summary for RPL28 Gene

RPL28 (Ribosomal Protein L28) is a Protein Coding gene. Diseases associated with RPL28 include Albinism-Deafness Syndrome. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL28 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL28 Gene

Genomics for RPL28 Gene

Regulatory Elements for RPL28 Gene

Enhancers for RPL28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F055382 1.1 ENCODE 21.4 +1.8 1763 8.2 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 PAF1 ZNF263 SP3 RPL28 RFPL4AP1 RPL13P13 MIR6805 ZNF581 U2AF2 COX6B2 BRSK1 FAM71E2 SHISA7
GH19F055319 1.5 FANTOM5 Ensembl ENCODE 10.6 -63.4 -63424 4.0 SUZ12 CREB3L1 ZNF76 DEAF1 ZNF384 CEBPG ZNF644 ETS1 ZNF316 ELK1 FCAR CDC42EP5 TMEM150B FAM71E2 IL11 TMEM190 BRSK1 HSPBP1 PPP6R1 MIR6805
GH19F055405 1.4 FANTOM5 ENCODE 10.9 +22.3 22325 3.7 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF416 ZNF207 ENSG00000269873 NAT14 MIR6805 LOC100506374 ZNF581 U2AF2 ZNF582-AS1 ZNF580 FIZ1 RPL28
GH19F055371 1.5 FANTOM5 Ensembl ENCODE 10.1 -9.7 -9701 7.1 ELF3 SIN3A ZNF48 RAD21 RARA GLIS2 FOS THAP11 SP5 CEBPB TMEM190 RPL28 FAM71E2 EPS8L1 ZNF628 IL11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL28 on UCSC Golden Path with GeneCards custom track

Promoters for RPL28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000348984 999 2201 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 SP3 SP5
ENSR00001818951 -1201 1401 BCOR TBP CTCF TAF1 SIN3A UBTF ZBTB40 BRCA1 RAD21 E2F1

Genomic Location for RPL28 Gene

55,385,101 bp from pter
55,403,250 bp from pter
18,150 bases
Plus strand

Genomic View for RPL28 Gene

Genes around RPL28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL28 Gene

Proteins for RPL28 Gene

  • Protein details for RPL28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L28
    Protein Accession:
    Secondary Accessions:
    • B2R4A6
    • B4DEP9
    • C9JB50
    • E9PB24
    • G5E9L2
    • Q6IAY0
    • Q96FX1
    • Q9BWQ0

    Protein attributes for RPL28 Gene

    137 amino acids
    Molecular mass:
    15748 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL28 Gene

    Alternative splice isoforms for RPL28 Gene


neXtProt entry for RPL28 Gene

Post-translational modifications for RPL28 Gene

  • Ubiquitination at Lys 19, Lys 22, Lys 33, Lys 47, Lys 58, Lys 65, Lys 72, and Lys 101
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL28 Gene

Domains & Families for RPL28 Gene

Gene Families for RPL28 Gene

Protein Domains for RPL28 Gene

Suggested Antigen Peptide Sequences for RPL28 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L28e family.
  • Belongs to the ribosomal protein L28e family.
genes like me logo Genes that share domains with RPL28: view

Function for RPL28 Gene

Molecular function for RPL28 Gene

GENATLAS Biochemistry:
60S ribosomal protein L28,15kDa

Gene Ontology (GO) - Molecular Function for RPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7772601
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 20434207
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL28: view
genes like me logo Genes that share phenotypes with RPL28: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL28 Gene

Localization for RPL28 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL28 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL28 Gene

Pathways & Interactions for RPL28 Gene

genes like me logo Genes that share pathways with RPL28: view

Pathways by source for RPL28 Gene

Gene Ontology (GO) - Biological Process for RPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL28: view

No data available for SIGNOR curated interactions for RPL28 Gene

Transcripts for RPL28 Gene

Unigene Clusters for RPL28 Gene

Ribosomal protein L28:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL28 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - -
SP2: - - - - - -
SP3: - - -
SP5: - - -

Relevant External Links for RPL28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL28 Gene

This gene is overexpressed in Nasal epithelium (14.8) and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL28 Gene

Protein tissue co-expression partners for RPL28 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL28 Gene:


SOURCE GeneReport for Unigene cluster for RPL28 Gene:

genes like me logo Genes that share expression patterns with RPL28: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL28 Gene

Orthologs for RPL28 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL28 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL28 35
  • 99 (a)
(Bos Taurus)
Mammalia RPL28 34 35
  • 90.27 (n)
(Canis familiaris)
Mammalia RPL28 34 35
  • 90.02 (n)
(Mus musculus)
Mammalia Rpl28 34 16 35
  • 89.29 (n)
Rpl28-ps4 35
  • 66 (a)
(Rattus norvegicus)
Mammalia Rpl28 34
  • 89.05 (n)
(Monodelphis domestica)
Mammalia RPL28 35
  • 76 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 72 (a)
-- 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl28 34
  • 70.07 (n)
Str.5096 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.17523 34
(Danio rerio)
Actinopterygii rpl28 34 35
  • 76.96 (n)
zgc66289 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8348 34
fruit fly
(Drosophila melanogaster)
Insecta RpL28 34 35
  • 56.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005427 34
  • 56.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4607 35
  • 53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06210 34
  • 51.79 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl44 34
  • 43.44 (n)
Species where no ortholog for RPL28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPL28 Gene

Gene Tree for RPL28 (if available)
Gene Tree for RPL28 (if available)

Paralogs for RPL28 Gene

genes like me logo Genes that share paralogs with RPL28: view

No data available for Paralogs for RPL28 Gene

Variants for RPL28 Gene

Sequence variations from dbSNP and Humsavar for RPL28 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10410269 -- 55,388,113(+) TCCCA(C/T)TACTG intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, missense
rs10411984 -- 55,388,181(+) AGCAT(A/G/T)GGCCT intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense
rs10416908 -- 55,388,764(+) GGGGA(C/T)GACAG intron-variant, utr-variant-3-prime
rs10418020 -- 55,388,572(+) AAAAG(C/T)TTGCT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs10420818 -- 55,385,813(+) GGAAG(C/T)AGCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL28 Gene

Variant ID Type Subtype PubMed ID
nsv953624 CNV deletion 24416366
nsv516199 CNV loss 19592680
nsv470162 CNV loss 18288195

Variation tolerance for RPL28 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.70; 91.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL28 Gene

Disorders for RPL28 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL28 Gene - From: GeneCards

Disorder Aliases PubMed IDs
albinism-deafness syndrome
  • albinism deafness syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPL28 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPL28

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL28 Gene

Publications for RPL28 Gene

  1. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio J.-M. … Iovanna J.L. (Biochim. Biophys. Acta 1995) 2 3 4 64
  2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova T.I. … Karpova G.G. (J. Protein Chem. 2003) 3 4 64

Products for RPL28 Gene

Sources for RPL28 Gene

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