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Aliases for RPL28 Gene

Aliases for RPL28 Gene

  • Ribosomal Protein L28 2 3 5
  • 60S Ribosomal Protein L28 2
  • L28 3

External Ids for RPL28 Gene

Previous GeneCards Identifiers for RPL28 Gene

  • GC19P056761
  • GC19P056320
  • GC19P060571
  • GC19P060589
  • GC19P055897
  • GC19P052219

Summaries for RPL28 Gene

Entrez Gene Summary for RPL28 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

GeneCards Summary for RPL28 Gene

RPL28 (Ribosomal Protein L28) is a Protein Coding gene. Diseases associated with RPL28 include Albinism-Deafness Syndrome. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL28 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL28 Gene

Genomics for RPL28 Gene

Regulatory Elements for RPL28 Gene

Enhancers for RPL28 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPL28 on UCSC Golden Path with GeneCards custom track

Promoters for RPL28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL28 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL28 Gene

55,385,101 bp from pter
55,403,250 bp from pter
18,150 bases
Plus strand

Genomic View for RPL28 Gene

Genes around RPL28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL28 Gene

Proteins for RPL28 Gene

  • Protein details for RPL28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L28
    Protein Accession:
    Secondary Accessions:
    • B2R4A6
    • B4DEP9
    • C9JB50
    • E9PB24
    • G5E9L2
    • Q6IAY0
    • Q96FX1
    • Q9BWQ0

    Protein attributes for RPL28 Gene

    137 amino acids
    Molecular mass:
    15748 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL28 Gene

    Alternative splice isoforms for RPL28 Gene


neXtProt entry for RPL28 Gene

Proteomics data for RPL28 Gene at MOPED

Post-translational modifications for RPL28 Gene

  • Ubiquitination at Lys 19, Lys 22, Lys 33, Lys 47, Lys 58, Lys 65, Lys 72, and Lys 101
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL28 Gene

Domains & Families for RPL28 Gene

Gene Families for RPL28 Gene

Protein Domains for RPL28 Gene

Suggested Antigen Peptide Sequences for RPL28 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L28e family.
  • Belongs to the ribosomal protein L28e family.
genes like me logo Genes that share domains with RPL28: view

Function for RPL28 Gene

Molecular function for RPL28 Gene

GENATLAS Biochemistry:
60S ribosomal protein L28,15kDa
genes like me logo Genes that share phenotypes with RPL28: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL28 Gene

Localization for RPL28 Gene

Subcellular locations from

Jensen Localization Image for RPL28 Gene COMPARTMENTS Subcellular localization image for RPL28 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 3
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0030425 dendrite IDA 15121898
genes like me logo Genes that share ontologies with RPL28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL28 Gene

Pathways & Interactions for RPL28 Gene

genes like me logo Genes that share pathways with RPL28: view

Pathways by source for RPL28 Gene

Gene Ontology (GO) - Biological Process for RPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL28: view

No data available for SIGNOR curated interactions for RPL28 Gene

Drugs & Compounds for RPL28 Gene

No Compound Related Data Available

Transcripts for RPL28 Gene

Unigene Clusters for RPL28 Gene

Ribosomal protein L28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL28 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - -
SP2: - - - - - -
SP3: - - -
SP5: - - -

Relevant External Links for RPL28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL28 Gene

mRNA expression in normal human tissues for RPL28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL28 Gene

This gene is overexpressed in Nasal epithelium (14.8) and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RPL28 Gene

SOURCE GeneReport for Unigene cluster for RPL28 Gene Hs.652114

genes like me logo Genes that share expression patterns with RPL28: view

Protein tissue co-expression partners for RPL28 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL28 Gene

Orthologs for RPL28 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL28 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL28 35
  • 90.27 (n)
  • 97.81 (a)
RPL28 36
  • 81 (a)
(Canis familiaris)
Mammalia RPL28 35
  • 90.02 (n)
  • 98.54 (a)
RPL28 36
  • 81 (a)
(Mus musculus)
Mammalia Rpl28 35
  • 89.29 (n)
  • 98.54 (a)
Rpl28 16
Rpl28 36
  • 81 (a)
Rpl28-ps4 36
  • 66 (a)
(Rattus norvegicus)
Mammalia Rpl28 35
  • 89.05 (n)
  • 98.54 (a)
(Monodelphis domestica)
Mammalia RPL28 36
  • 76 (a)
(Pan troglodytes)
Mammalia RPL28 36
  • 99 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
-- 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl28 35
  • 70.07 (n)
  • 79.56 (a)
Str.5096 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.17523 35
(Danio rerio)
Actinopterygii rpl28 35
  • 76.96 (n)
  • 80.15 (a)
zgc66289 35
rpl28 36
  • 67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8348 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005427 35
  • 56.35 (n)
  • 48.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL28 35
  • 56.49 (n)
  • 46.56 (a)
RpL28 36
  • 33 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06210 35
  • 51.79 (n)
  • 44.63 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl44 35
  • 43.44 (n)
  • 39.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4607 36
  • 53 (a)
Species with no ortholog for RPL28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPL28 Gene

Gene Tree for RPL28 (if available)
Gene Tree for RPL28 (if available)

Paralogs for RPL28 Gene

genes like me logo Genes that share paralogs with RPL28: view

No data available for Paralogs for RPL28 Gene

Variants for RPL28 Gene

Sequence variations from dbSNP and Humsavar for RPL28 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_034460 -
rs7260246 -- 55,391,956(+) CTGCC(A/C/T)GTGTT intron-variant, utr-variant-3-prime
rs7260639 -- 55,391,634(+) ctgtg(C/T)cttcg intron-variant, reference, synonymous-codon, utr-variant-3-prime
rs12977195 -- 55,398,424(+) gttcc(A/T)actgg intron-variant
rs12977341 -- 55,398,342(+) GAAAC(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL28 Gene

Variant ID Type Subtype PubMed ID
dgv4016n71 CNV Loss 21882294
nsv912457 CNV Loss 21882294
nsv912460 CNV Loss 21882294
nsv912461 CNV Loss 21882294
nsv470162 CNV Loss 18288195
dgv4017n71 CNV Loss 21882294
nsv912463 CNV Loss 21882294
nsv516199 CNV Loss 19592680
dgv4020n71 CNV Loss 21882294
nsv912473 CNV Loss 21882294

Variation tolerance for RPL28 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.70; 91.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPL28 Gene

Disorders for RPL28 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL28 Gene - From: GeneCards

Disorder Aliases PubMed IDs
albinism-deafness syndrome
  • albinism deafness syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPL28 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPL28

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL28 Gene

Publications for RPL28 Gene

  1. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio J.-M. … Iovanna J.L. (Biochim. Biophys. Acta 1995) 2 3 4 67
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Proteomic analysis of HIV-1 Gag interacting partners using proximity-dependent biotinylation. (PMID: 26362536) Le Sage V. … Mouland A.J. (Virol. J. 2015) 3

Products for RPL28 Gene

Sources for RPL28 Gene