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Aliases for RPL27A Gene

Aliases for RPL27A Gene

  • Ribosomal Protein L27a 2 3
  • 60S Ribosomal Protein L27a 3
  • L27A 3

External Ids for RPL27A Gene

Previous GeneCards Identifiers for RPL27A Gene

  • GC11P009474
  • GC11P009150
  • GC11P008743
  • GC11P008668
  • GC11P008660
  • GC11P008703
  • GC11P008371

Summaries for RPL27A Gene

Entrez Gene Summary for RPL27A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL27A Gene

RPL27A (Ribosomal Protein L27a) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL27A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL27A Gene

Genomics for RPL27A Gene

Regulatory Elements for RPL27A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPL27A Gene

Start:
8,682,411 bp from pter
End:
8,714,759 bp from pter
Size:
32,349 bases
Orientation:
Plus strand

Genomic View for RPL27A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL27A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL27A Gene

Proteins for RPL27A Gene

  • Protein details for RPL27A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46776-RL27A_HUMAN
    Recommended name:
    60S ribosomal protein L27a
    Protein Accession:
    P46776
    Secondary Accessions:
    • B2R4B3

    Protein attributes for RPL27A Gene

    Size:
    148 amino acids
    Molecular mass:
    16561 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL27A Gene

neXtProt entry for RPL27A Gene

Proteomics data for RPL27A Gene at MOPED

Post-translational modifications for RPL27A Gene

Other Protein References for RPL27A Gene

No data available for DME Specific Peptides for RPL27A Gene

Domains for RPL27A Gene

Gene Families for RPL27A Gene

HGNC:
  • RPL :L ribosomal proteins

Protein Domains for RPL27A Gene

Suggested Antigen Peptide Sequences for RPL27A Gene

Graphical View of Domain Structure for InterPro Entry

P46776

UniProtKB/Swiss-Prot:

RL27A_HUMAN :
  • P46776
Family:
  • Belongs to the ribosomal protein L15P family.
genes like me logo Genes that share domains with RPL27A: view

Function for RPL27A Gene

Molecular function for RPL27A Gene

GENATLAS Biochemistry: 60S ribosomal protein L27A,16kDa

Gene Ontology (GO) - Molecular Function for RPL27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7772601
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 20195357
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RPL27A: view
genes like me logo Genes that share phenotypes with RPL27A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL27A Gene

Localization for RPL27A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL27A Gene COMPARTMENTS Subcellular localization image for RPL27A gene
Compartment Confidence
cytosol 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
genes like me logo Genes that share ontologies with RPL27A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL27A Gene

Pathways for RPL27A Gene

genes like me logo Genes that share pathways with RPL27A: view

Pathways by source for RPL27A Gene

1 KEGG pathway for RPL27A Gene
1 GeneGo (Thomson Reuters) pathway for RPL27A Gene

Gene Ontology (GO) - Biological Process for RPL27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL27A: view

Transcripts for RPL27A Gene

Unigene Clusters for RPL27A Gene

Ribosomal protein L27a:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL27A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL27A Gene

No ASD Table

Relevant External Links for RPL27A Gene

GeneLoc Exon Structure for
RPL27A
ECgene alternative splicing isoforms for
RPL27A

Expression for RPL27A Gene

mRNA expression in normal human tissues for RPL27A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL27A Gene

SOURCE GeneReport for Unigene cluster for RPL27A Gene Hs.523463

genes like me logo Genes that share expressions with RPL27A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL27A Gene

Orthologs for RPL27A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL27A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL27A 35
  • 99.77 (n)
  • 99.32 (a)
RPL27A 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 97 (a)
OneToMany
RPL27A 35
  • 92.12 (n)
  • 97.97 (a)
dog
(Canis familiaris)
Mammalia RPL27A 35
  • 90.99 (n)
  • 97.97 (a)
RPL27A 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm7536 36
  • 97 (a)
OneToMany
Rpl27a 35
  • 90.99 (n)
  • 97.3 (a)
Rpl27a 16
Rpl27a 36
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPL27A 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rpl27a 35
  • 88.96 (n)
  • 96.62 (a)
chicken
(Gallus gallus)
Aves RPL27A 35
  • 80.18 (n)
  • 92.57 (a)
RPL27A 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 86 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl27a 35
  • 77.03 (n)
  • 89.86 (a)
Str.14185 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8028 35
zebrafish
(Danio rerio)
Actinopterygii rpl27a 35
  • 75.23 (n)
  • 86.49 (a)
wufa93g12 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011706 35
  • 67.14 (n)
  • 73.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL27A 35
  • 66.67 (n)
  • 69.23 (a)
RpL27A 36
  • 66 (a)
OneToOne
RpL27A 37
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea Y37E3.8 35
  • 65.52 (n)
  • 71.03 (a)
Y37E3.8 36
  • 70 (a)
OneToOne
Y37E3.8a 37
  • 69 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL035C 35
  • 63.06 (n)
  • 64.19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL28 35
  • 60.59 (n)
  • 62.16 (a)
RPL28 36
  • 61 (a)
OneToOne
RPL28 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06831g 35
  • 61.71 (n)
  • 64.19 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.184 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G70600 35
  • 68.28 (n)
  • 66.21 (a)
corn
(Zea mays)
Liliopsida Zm.16909 35
rice
(Oryza sativa)
Liliopsida Os03g0408300 35
  • 63.91 (n)
  • 64.14 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03806 35
  • 61.19 (n)
  • 62.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2801 35
  • 61.26 (n)
  • 64.86 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2593 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6935 36
  • 79 (a)
OneToOne
Species with no ortholog for RPL27A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL27A Gene

ENSEMBL:
Gene Tree for RPL27A (if available)
TreeFam:
Gene Tree for RPL27A (if available)

Paralogs for RPL27A Gene

Selected SIMAP similar genes for RPL27A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RPL27A: view

No data available for Paralogs for RPL27A Gene

Variants for RPL27A Gene

Sequence variations from dbSNP and Humsavar for RPL27A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1057198 -- 8,687,392(+) TGTCC(A/C)CCCCC utr-variant-3-prime
rs1135249 -- 8,687,288(+) cagct(A/G)ctttg utr-variant-3-prime
rs2036422 -- 8,687,790(+) CGCCC(A/G)GCTAA utr-variant-3-prime
rs3833782 -- 8,689,406(-) AACCT(-/CCT)AAGAG cds-indel
rs3841218 -- 8,688,411(+) CTAAC(-/AG)TTCTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL27A Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241

Relevant External Links for RPL27A Gene

HapMap Linkage Disequilibrium report
RPL27A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL27A Gene

Disorders for RPL27A Gene

No disorders were found for RPL27A Gene.

No data available for UniProtKB/Swiss-Prot for RPL27A Gene

Publications for RPL27A Gene

  1. Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A. (PMID: 10449908) Kusuda J. … Hashimoto K. (Cytogenet. Cell Genet. 1999) 3 4 23
  2. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio J.-M. … Iovanna J.L. (Biochim. Biophys. Acta 1995) 2 3 4
  3. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RPL27A Gene

Sources for RPL27A Gene

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