Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPL27A Gene

protein-coding GIFtS: 61
GCID: GC11P008703

ribosomal protein L27a

Explore 3 diseases affiliated with
RPL27A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribosomal Protein L27a¹ ²
L27A¹ ²
60S Ribosomal Protein L27a²

External Ids:	HGNC: 10329¹	Entrez Gene: 6157²	Ensembl: ENSG00000166441⁷	OMIM: 603637⁵	UniProtKB: P46776³

Export aliases for RPL27A gene to outside databases

Previous GC identifers: GC11P009474 GC11P009150 GC11P008743 GC11P008668 GC11P008660 GC11P008371

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL27A:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.

Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene

encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15P family of

ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to

adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of

the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes

derived from this gene are dispersed through the genome. (provided by RefSeq, Jul 2008)

Gene Wiki entry for RPL27A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPL27A gene promoter:
AML1a GCNF c-Ets-1 RORalpha2 PPAR-gamma1 FOXO4 GCNF-1 FOXO1a GCNF-2 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPL27A promoter sequence

Search SABiosciences Chromatin IP Primers for RPL27A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL27A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15

RPL27A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL27A gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P008703: view genomic region (about GC identifiers)

Start:	8,703,958 bp from pter	End:	8,736,306 bp from pter
Size:	32,349 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RL27A_HUMAN, P46776 (See protein sequence)

Recommended Name: 60S ribosomal protein L27a

Size: 148 amino acids; 16561 Da

Secondary accessions: B2R4B3

Explore the universe of human proteins at neXtProt for RPL27A: NX_P46776

Post-translational modifications:

Hydroxylated on His-39 by MINA¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P46776

RPL27A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000981.1

ENSEMBL proteins:

ENSP00000346015 ENSP00000433259 ENSP00000431849 ENSP00000435333 ENSP00000435081

ENSP00000432671 ENSP00000431565 ENSP00000437118 ENSP00000433766

Reactome Protein details: P46776
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: RPL27A OriGene Custom Protein Services for RPL27A
	GenScript Custom Purified and Recombinant Proteins Services for RPL27A
	Novus Biologicals RPL27A Proteins Novus Biologicals RPL27A Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RPL27A

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005840	ribosome	--	--
GO:0022625	cytosolic large ribosomal subunit	IDA	12962325

RPL27A for ontologies About GeneDecksing

RPL27A Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for RPL27A
	GenScript Custom Superior Antibodies Services for RPL27A
	Novus Biologicals RPL27A Antibodies
	Search for Antibodies for RPL27A at Abcam
	Uscn Antibodies for RPL27A
	ThermoFisher Antibody for RPL27A

Assay Products for RPL27A:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RPL27A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RPL27A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPL27A for domains About GeneDecksing

2 InterPro domains/families:

IPR021131 Ribosomal_L18e/L15P

IPR001196 Ribosomal_L15_CS

Graphical View of Domain Structure for InterPro Entry P46776

ProtoNet protein and cluster: P46776

1 Blocks protein family: IPB001196 Ribosomal protein L15

UniProtKB/Swiss-Prot: RL27A_HUMAN, P46776

Similarity: Belongs to the ribosomal protein L15P family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for RPL27A:

60S ribosomal protein L27A,16kDa

miRNA Products:		OriGene 3'-UTR Clone: RPL27A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPL27A
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate RPL27A:
		hsa-miR-586 hsa-miR-548b-3p hsa-miR-1179
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL27A (see all 7) OriGene shRNA RFP: RPL27A OriGene siRNA: RPL27A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL27A

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RPL27A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL27A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL27A OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RPL27A (NM_000990)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL27A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL27A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RPL27A
		Search LifeMap BioReagents cell lines for RPL27A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL27A

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	TAS	7772601
GO:0003735	structural constituent of ribosome	NAS	12962325
GO:0005515	protein binding	IPI	--

RPL27A for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for RPL27A:

Increased S DNA content	Nuclear 40S maturation defects	Nuclear 60S biogenesis defects	Nucleolar pre-40S maturation d
S arrest

Animal Models:
13 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rpl27a):

behavior/neurological	craniofacial	growth/size	hearing/vestibular/ear	hematopoietic system
immune system	integument	limbs/digits/tail	mortality/aging	nervous system
normal	pigmentation	tumorigenesis

RPL27A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of PB1-F2

8/26 pathways (see all 26)
Viral Protein Synthesis	1.00	Cytoplasmic Ribosomal Proteins	0.86
Viral mRNA Translation	1.00	CFTR translational fidelity (class I mutations)	0.83
Influenza Viral RNA Transcription and Replication	1.00	SMG6 Cleaves mRNA with Premature Termination Codon	0.80
Synthesis of nascent polypeptide containing signal sequence	1.00	L13a-mediated translational silencing of Ceruloplasmin expression	0.79

Metabolism of mRNA

Metabolism of mRNA

1.00

Metabolism of RNA

0.92

Disease

Disease

1.00

Generic Transcription Pathway

Gene Expression

0.46

Asparagine N-linked glycosylation

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for RPL27A

CFTR translational fidelity (class I mutations)

1 BioSystems Pathway for RPL27A

Cytoplasmic Ribosomal Proteins

5/28 Reactome Pathways for RPL27A (see all 28)

	Nonsense Mediated Decay Independent of the Exon Junction Complex
	Nonsense-Mediated Decay
	Translation
	SRP-dependent cotranslational protein targeting to membrane
	Eukaryotic Translation Initiation

1 Kegg Pathway (Kegg details for RPL27A):

Ribosome

RPL27A for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RPL27A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/395 Interacting proteins for RPL27A (P46776^{1, 2, 3} ENSP00000346015⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 395)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPL4	P36578²^,³, ENSP00000311430⁴	MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=4 STRING: ENSP00000311430
RPL11	P62913²^,³, ENSP00000363676⁴	MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=3 STRING: ENSP00000363676
RPL26	P61254²^,³, ENSP00000293842⁴	MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=3 STRING: ENSP00000293842
RPL35	P42766²^,³, ENSP00000259469⁴	MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=3 STRING: ENSP00000259469
RPS15A	P62244²^,³, ENSP00000318646⁴	MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=3 STRING: ENSP00000318646

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	--
GO:0006412	translation	TAS	--
GO:0006413	translational initiation	TAS	--
GO:0006414	translational elongation	TAS	--
GO:0006415	translational termination	TAS	--

RPL27A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RPL27A
Search CenterWatch for drugs/clinical trials and news about RPL27A / RL27A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RPL27A gene (2 alternative transcripts):

NM_000990.4 NM_032650.1

Unigene Cluster for RPL27A:

Ribosomal protein L27a

Hs.523463 [show with all ESTs]

Unigene Representative Sequence: NM_000990

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000314138(uc001mgs.4) ENST00000529227 ENST00000530585 ENST00000531978

ENST00000524496 ENST00000534599 ENST00000532359 ENST00000530022 ENST00000526562

ENST00000525981 ENST00000530913 ENST00000531102

miRNA Products:		OriGene 3'-UTR Clone: RPL27A Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPL27A
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate RPL27A:
		hsa-miR-586 hsa-miR-548b-3p hsa-miR-1179
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL27A (see all 7) OriGene shRNA RFP: RPL27A OriGene siRNA: RPL27A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL27A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL27A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL27A OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RPL27A (NM_000990)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL27A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL27A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPL27A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RPL27A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL27A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL27A

Additional cDNA sequence:

AJ609428.1 AK125453.1 AK311767.1 AM055744.1 BC004284.1 BC005326.1 BC014919.1 BC020169.1

BC066326.1 NR_002580.1 NR_002977.1 U14968.1

24/53 DOTS entries (see all 53):

DT.451082 DT.95072701 DT.100894777 DT.100685013 DT.97863626 DT.92040607 DT.100685021 DT.100685029

DT.91668870 DT.100685022 DT.101955251 DT.120725941 DT.100800558 DT.96085467 DT.92047273 DT.86993305

DT.101987246 DT.121408570 DT.405560 DT.120726014 DT.95139231 DT.100653590 DT.87007600 DT.100058029

24/1860 AceView cDNA sequences (see all 1860):

BQ055403 AA364059 BQ068704 BE255870 BU500974 AA806570 AI399687 AI348596

BU786017 BM679409 BI906450 BM853704 BI771373 BG335577 AI951310 BF058463

AA906613 AI338022 AI279580 AI468842 BF222301 AA551991 AA846700 AI688166

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPL27A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGGAGTTT

About this image

RPL27A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm-like cells (Generation of hepato...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RPL27A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPL27A

SOURCE GeneReport for Unigene cluster: Hs.523463

SABiosciences Custom PCR Arrays for RPL27A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPL27A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RPL27A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL27A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL27A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL27A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL27A gene from 10/37 species (see all 37) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rpl27a^{1 , 5}	ribosomal protein L27A^{1, 5}	90.99(n)¹ 97.3(a)¹		7 (57.26 cM)⁵ 26451¹ NM_011975.3¹ NP_036105.2¹ 109519147⁵
chicken (Gallus gallus)	Aves	RPL27A¹	ribosomal protein L27a	80.18(n) 92.57(a)		770018 XM_001233332.2 XP_001233333.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	91(a) 91(a)	many → 1 many → 1	2(112667925-112671412) GL343770.1(32022-36559)
African clawed frog (Xenopus laevis)	Amphibia	BC053769.1²	--	78.12(n)		BC053769.1
zebrafish (Danio rerio)	Actinopterygii	wufa93g12²	wufa93g12	79.57(n)		336726 BC064441.1
fruit fly (Drosophila melanogaster)	Insecta	RpL27A^{1 , 3}	protein biosynthesis structural constituent of more³ Ribosomal protein L27A¹	68(a)³ 66.67(n)¹ 69.23(a)¹		2³ 33654¹ NM_057615.4¹ NP_476963.1¹
worm (Caenorhabditis elegans)	Secernentea	Y37E3.8a³ Y37E3.8¹	Protein Y37E3.8¹	69(a)³ 65.52(n)¹ 71.03(a)¹		I(2069723-2070606)³ 171767¹ NM_058526.5¹ NP_490927.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPL28(YGL103W)⁴ RPL28¹	Ribosomal protein of the large (60S) ribosomal subunit, more⁴ Rpl28p¹	60.59(n)¹ 62.16(a)¹		7(310967-311927)⁴ 852775^{1, 4} NP_011412.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G70600¹	60S ribosomal protein L27a-3	68.51(n) 66.21(a)		843397 NM_105728.3 NP_177217.1
rice (Oryza sativa)	Liliopsida	BI803160.1²	--	74.25(n)		BI803160.1

ENSEMBL Gene Tree for RPL27A (if available)
TreeFam Gene Tree for RPL27A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RPL27A gene

4 SIMAP similar genes for RPL27A using alignment to 7 protein entries: RL27A_HUMAN (see all proteins):

FAM175A PTPLA L27a RANBP3

RPL27A for paralogs About GeneDecksing

5/8 Pseudogenes.org Pseudogenes for RPL27A (see all 8)
PGOHUM00000248393 PGOHUM00000234851 PGOHUM00000245039 PGOHUM00000258116 PGOHUM00000240446

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111656735^1,2	C,	--	8702001(+)	`AAGGCG/-AGGGC`	1	--	us2k¹		1		CSA	2
rs80149146^1,2	C,	--	8702004(+)	`AGGCA-/GGGGCA`	1	--	us2k¹		0	--	--	--	--
rs35905151^1,2	C	--	8702005(+)	`CAGGGG/-CACTA`	1	--	us2k¹		1		NA	2
rs61045588^1,2	F,	--	8702016(+)	`TAAGGC/TTTAAA`	1	--	us2k¹		1		WA	118
rs139705308^1,2		--	8702024(+)	`AAACAC/GAGGAA`	1	--	us2k¹		0	--	--	--	--
rs182008544^1,2		--	8702035(+)	`GCACAC/TTGGGG`	1	--	us2k¹		0	--	--	--	--
rs78966200^1,2	F,	--	8702036(+)	`CACATT/CGGGGA`	1	--	us2k¹		1		EA	120
rs116443870^1,2		--	8702052(+)	`AGAAAC/GAAAAG`	1	--	us2k¹		1		WA	118
rs184306562^1,2	C,	--	8702056(+)	`ACAAAA/GGGATA`	1	--	us2k¹		0	--	--	--	--
rs112369934^1,2	C,	--	8702073(+)	`CAGTGT/CAGTAG`	1	--	us2k¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for RPL27A (8703958 - 8736306 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RPL27A: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL27A

DNA2.0 Custom Variant and Variant Library Synthesis for RPL27A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RPL27A for disorders           About GeneDecksing

OMIM gene information: 603637    OMIM disorders: --

3 diseases for RPL27A:    About MalaCards

treacher collins syndrome colorectal cancer malaria

Export disorders for RPL27A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RPL27A gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with RPL27A)

Utopia: connect your pdf to the dynamic
world of online information

A map of 75 human ribosomal protein genes. (PubMed id 9582194)^{1, 2, 3} Kenmochi N.... Page D.C. (1998)
Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PubMed id 7772601)^{1, 2, 3} Frigerio J.-M.... Iovanna J.L. (1995)
Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A. (PubMed id 10449908)^{1, 2, 9} Kusuda J.... Hashimoto K. (1999)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. (PubMed id 23103944)² Ge W....Schofield C.J. (2012)
An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)¹ Neganova I....Lako M. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6157	HGNC: 10329	AceView: RPL27A	Ensembl:ENSG00000166441	euGenes: HUgn6157
ECgene: RPL27A	Kegg: 6157	H-InvDB: RPL27A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RPL27A	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RPL27A	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RPL27A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RPL27A gene:
Search GeneIP for patents involving RPL27A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for RPL27A
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL27A		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPL27A
	OriGene Protein Over-expression Lysate for RPL27A		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for RPL27A		OriGene 3'-UTR Clone for RPL27A
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL27A		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL27A
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RPL27A		OriGene Custom Protein Services for RPL27A
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPL27A
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL27A
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL27A
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL27A
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL27A
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL27A

	GenScript Custom Purified and Recombinant Proteins Services for RPL27A		GenScript cDNA clones with any tag delivered in your preferred vector for RPL27A
	GenScript Custom Assay Services for RPL27A		GenScript Custom Superior Antibodies Services for RPL27A
	GenScript Custom overexpressing Cell Line Services for RPL27A		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RPL27A promoter
	Search Chromatin IP Primers for RPL27A
	RT² qPCR Primer Assay in human, mouse, rat RPL27A
	Search GNC Networks for RPL27A
	SABiosciences Custom PCR Arrays for RPL27A

Search Tocris compounds for RPL27A

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RPL27A antibodies
	RPL27A proteins
	RPL27A lysates

	Search for Antibodies for RPL27A at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for RPL27A
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

RPL27A Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for RPL27A

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL27A

	Browse SwitchGear 3'UTR luciferase reporter plasmids for RPL27A
	SwitchGear Promoter luciferase reporter plasmids for RPL27A

ThermoFisher Antibody for RPL27A

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL27A

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RPL27A gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

RPL27A Gene

ribosomal protein L27a

Aliases
for RPL27A gene

Summaries
for RPL27A gene

Genomic Views
for RPL27A gene

Proteins
for RPL27A gene

Protein Domains /
Families
for RPL27A gene

Function
for RPL27A gene

Pathways & Interactions
for RPL27A gene

Drugs & Compounds
for RPL27A gene

Transcripts
for RPL27A gene

Expression
for RPL27A gene

Orthologs
for RPL27A gene

Paralogs
for RPL27A gene

Genomic Variants
for RPL27A gene

Disorders / Diseases
for RPL27A gene

Publications
for RPL27A gene

External Searches for RPL27A gene

Genome Databases showing RPL27A gene

Other Databases showing RPL27A gene

Specialized Databases showing RPL27A gene

Intellectual Property
for RPL27A gene

Products
for RPL27A gene

View Random Gene

Advanced Search

Export list of displayed genes

RPL27A Gene

ribosomal protein L27a

Aliasesfor RPL27A gene

Summariesfor RPL27A gene

Genomic Viewsfor RPL27A gene

Proteinsfor RPL27A gene

Protein Domains /Familiesfor RPL27A gene

Functionfor RPL27A gene

Pathways & Interactionsfor RPL27A gene

Drugs & Compoundsfor RPL27A gene

Transcriptsfor RPL27A gene

Expression for RPL27A gene

Orthologsfor RPL27A gene

Paralogsfor RPL27A gene

Genomic Variantsfor RPL27A gene

Disorders / Diseasesfor RPL27A gene

Publicationsfor RPL27A gene

External Searches for RPL27A gene

Genome Databases showing RPL27A gene

Other Databases showing RPL27A gene

Specialized Databases showing RPL27A gene

Intellectual Propertyfor RPL27A gene

Productsfor RPL27A gene

View Random Gene

Aliases
for RPL27A gene

Summaries
for RPL27A gene

Genomic Views
for RPL27A gene

Proteins
for RPL27A gene

Protein Domains /
Families
for RPL27A gene

Function
for RPL27A gene

Pathways & Interactions
for RPL27A gene

Drugs & Compounds
for RPL27A gene

Transcripts
for RPL27A gene

Expression
for RPL27A gene

Orthologs
for RPL27A gene

Paralogs
for RPL27A gene

Genomic Variants
for RPL27A gene

Disorders / Diseases
for RPL27A gene

Publications
for RPL27A gene

Intellectual Property
for RPL27A gene

Products
for RPL27A gene