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Aliases for RPL27A Gene

Aliases for RPL27A Gene

  • Ribosomal Protein L27a 2 3 5
  • 60S Ribosomal Protein L27a 3
  • L27A 3

External Ids for RPL27A Gene

Previous GeneCards Identifiers for RPL27A Gene

  • GC11P009474
  • GC11P009150
  • GC11P008743
  • GC11P008668
  • GC11P008660
  • GC11P008703
  • GC11P008371

Summaries for RPL27A Gene

Entrez Gene Summary for RPL27A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL27A Gene

RPL27A (Ribosomal Protein L27a) is a Protein Coding gene. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL27A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL27A Gene

Genomics for RPL27A Gene

Regulatory Elements for RPL27A Gene

Enhancers for RPL27A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F009361 1.9 FANTOM5 Ensembl ENCODE 19.5 +681.1 681105 4.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 ZNF143 DENND5A SNORA3B NRIP3 WEE1 RPL21P97 TMEM9B-AS1 RPL27A AKIP1 ENSG00000254397
GH11F009458 1.2 ENCODE 19.8 +779.0 778988 5.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 SNORA3B TMEM9B-AS1 WEE1 RPL27A RPL21P97 ENSG00000254397 IPO7 LOC644656 PIR40365
GH11F008731 1.4 VISTA Ensembl ENCODE 11.2 +50.6 50600 3.2 ATF1 PKNOX1 SIN3A ZSCAN9 RAD21 RARA YY1 MIXL1 ZNF680 NR2F2 AKIP1 ENSG00000254665 RPL27A SCUBE2 TMEM9B-AS1 TRIM66 PIR56836
GH11F009551 1.4 Ensembl ENCODE 11.1 +869.9 869852 1.8 HDGF ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SNORA3B WEE1 ENSG00000238387 RPL27A RPL21P97 AKIP1 ZNF143 PIR40365 LOC644656
GH11F008825 1.5 FANTOM5 Ensembl ENCODE 10.1 +148.6 148566 10.9 YBX3 HDGF HDAC1 PKNOX1 ZNF133 NFXL1 YBX1 GATA2 ZNF143 FOS TMEM9B-AS1 AKIP1 SCUBE2 WEE1 TMEM9B EIF3F RPL27A SNORA3A ENSG00000254665 ENSG00000254900
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL27A on UCSC Golden Path with GeneCards custom track

Promoters for RPL27A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000684794 589 2801 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207

Genomic Location for RPL27A Gene

Chromosome:
11
Start:
8,682,411 bp from pter
End:
8,714,759 bp from pter
Size:
32,349 bases
Orientation:
Plus strand

Genomic View for RPL27A Gene

Genes around RPL27A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL27A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL27A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL27A Gene

Proteins for RPL27A Gene

  • Protein details for RPL27A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46776-RL27A_HUMAN
    Recommended name:
    60S ribosomal protein L27a
    Protein Accession:
    P46776
    Secondary Accessions:
    • B2R4B3

    Protein attributes for RPL27A Gene

    Size:
    148 amino acids
    Molecular mass:
    16561 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL27A Gene

neXtProt entry for RPL27A Gene

Post-translational modifications for RPL27A Gene

No data available for DME Specific Peptides for RPL27A Gene

Domains & Families for RPL27A Gene

Gene Families for RPL27A Gene

Protein Domains for RPL27A Gene

Suggested Antigen Peptide Sequences for RPL27A Gene

Graphical View of Domain Structure for InterPro Entry

P46776

UniProtKB/Swiss-Prot:

RL27A_HUMAN :
  • Belongs to the ribosomal protein L15P family.
Family:
  • Belongs to the ribosomal protein L15P family.
genes like me logo Genes that share domains with RPL27A: view

Function for RPL27A Gene

Molecular function for RPL27A Gene

GENATLAS Biochemistry:
60S ribosomal protein L27A,16kDa

Gene Ontology (GO) - Molecular Function for RPL27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7772601
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 20195357
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RPL27A: view
genes like me logo Genes that share phenotypes with RPL27A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL27A Gene

Localization for RPL27A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL27A gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0015934 large ribosomal subunit IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL27A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL27A Gene

Pathways & Interactions for RPL27A Gene

genes like me logo Genes that share pathways with RPL27A: view

Pathways by source for RPL27A Gene

1 KEGG pathway for RPL27A Gene
1 GeneGo (Thomson Reuters) pathway for RPL27A Gene

Gene Ontology (GO) - Biological Process for RPL27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL27A: view

No data available for SIGNOR curated interactions for RPL27A Gene

Transcripts for RPL27A Gene

Unigene Clusters for RPL27A Gene

Ribosomal protein L27a:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL27A Gene

No ASD Table

Relevant External Links for RPL27A Gene

GeneLoc Exon Structure for
RPL27A
ECgene alternative splicing isoforms for
RPL27A

Expression for RPL27A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL27A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL27A Gene



Protein tissue co-expression partners for RPL27A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL27A Gene:

RPL27A

SOURCE GeneReport for Unigene cluster for RPL27A Gene:

Hs.523463
genes like me logo Genes that share expression patterns with RPL27A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL27A Gene

Orthologs for RPL27A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL27A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL27A 34 35
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 97 (a)
OneToMany
RPL27A 34
  • 92.12 (n)
mouse
(Mus musculus)
Mammalia Gm7536 35
  • 97 (a)
OneToMany
Rpl27a 34 16 35
  • 90.99 (n)
oppossum
(Monodelphis domestica)
Mammalia RPL27A 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL27A 34 35
  • 90.99 (n)
rat
(Rattus norvegicus)
Mammalia Rpl27a 34
  • 88.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves RPL27A 34 35
  • 80.18 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 91 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl27a 34
  • 77.03 (n)
Str.14185 34
zebrafish
(Danio rerio)
Actinopterygii rpl27a 34
  • 75.23 (n)
wufa93g12 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8028 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011706 34
  • 67.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL27A 36 34 35
  • 66.67 (n)
worm
(Caenorhabditis elegans)
Secernentea Y37E3.8a 36
  • 69 (a)
Y37E3.8 34 35
  • 65.52 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL035C 34
  • 63.06 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06831g 34
  • 61.71 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL28 34 35 37
  • 60.59 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G70600 34
  • 68.28 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.184 34
rice
(Oryza sativa)
Liliopsida Os03g0408300 34
  • 63.91 (n)
corn
(Zea mays)
Liliopsida Zm.16909 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6935 35
  • 79 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2801 34
  • 61.26 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03806 34
  • 61.19 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2593 34
Species where no ortholog for RPL27A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL27A Gene

ENSEMBL:
Gene Tree for RPL27A (if available)
TreeFam:
Gene Tree for RPL27A (if available)

Paralogs for RPL27A Gene

(4) SIMAP similar genes for RPL27A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RPL27A: view

No data available for Paralogs for RPL27A Gene

Variants for RPL27A Gene

Sequence variations from dbSNP and Humsavar for RPL27A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1049830 -- 8,685,797(-) GCCAC(A/C)AGGAC downstream-variant-500B, reference, synonymous-codon
rs1057198 -- 8,687,392(+) TGTCC(A/C)CCCCC utr-variant-3-prime
rs10769940 -- 8,680,922(+) AAAGT(A/G)CAACA intron-variant, upstream-variant-2KB
rs10769941 -- 8,688,697(+) AAATG(G/T)CTGCC utr-variant-3-prime
rs10840107 -- 8,680,595(+) CAAGA(C/T)AGAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL27A Gene

Variant ID Type Subtype PubMed ID
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855
nsv975880 CNV duplication 23825009

Variation tolerance for RPL27A Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL27A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL27A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL27A Gene

Disorders for RPL27A Gene

Relevant External Links for RPL27A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL27A

No disorders were found for RPL27A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL27A Gene

Publications for RPL27A Gene

  1. Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A. (PMID: 10449908) Kusuda J. … Hashimoto K. (Cytogenet. Cell Genet. 1999) 3 4 22 64
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 64
  3. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio J.-M. … Iovanna J.L. (Biochim. Biophys. Acta 1995) 2 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RPL27A Gene

Sources for RPL27A Gene

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