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Aliases for RPL27A Gene

Aliases for RPL27A Gene

  • Ribosomal Protein L27a 2 3 5
  • Large Ribosomal Subunit Protein UL15 3 4
  • 60S Ribosomal Protein L27a 3
  • L27A 3

External Ids for RPL27A Gene

Previous GeneCards Identifiers for RPL27A Gene

  • GC11P009474
  • GC11P009150
  • GC11P008743
  • GC11P008668
  • GC11P008660
  • GC11P008703
  • GC11P008371

Summaries for RPL27A Gene

Entrez Gene Summary for RPL27A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL27A Gene

RPL27A (Ribosomal Protein L27a) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL27A Gene

Additional gene information for RPL27A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL27A Gene

Genomics for RPL27A Gene

Regulatory Elements for RPL27A Gene

Enhancers for RPL27A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H008681 1.7 Ensembl ENCODE dbSUPER 21.3 +3.4 3445 8.7 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 TRIM66 SNORA3B EIF3F ZNF143 RPL21P97 RPL27A STK33 WEE1 RPL23AP65 ENSG00000254665
GH11H009458 1.4 ENCODE dbSUPER 19.8 +779.0 778988 5 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 SNORA3B RPL27A RPL21P97 TMEM9B-AS1 WEE1 TRIM66 IPO7 LOC644656 PIR40365
GH11H008731 1.6 VISTA Ensembl ENCODE dbSUPER 11.2 +50.6 50600 3.2 PKNOX1 ATF1 FOXA2 TBL1XR1 ZSCAN9 RAD21 RARA YY1 ATF7 MIXL1 AKIP1 ENSG00000254665 RPL27A SCUBE2 TMEM9B-AS1 TRIM66 PIR56836
GH11H008825 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10 +145.0 144966 3.7 HDAC1 YBX3 HDGF PKNOX1 ZSCAN4 YBX1 NFXL1 ZBTB40 TCF12 ELK1 AKIP1 TMEM9B-AS1 WEE1 EIF3F ZNF143 SNORA3A RPL27A ENSG00000254665 SCUBE2 RNA5SP330
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL27A on UCSC Golden Path with GeneCards custom track

Promoters for RPL27A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for RPL27A Gene

Genomic Locations for RPL27A Gene
32,349 bases
Plus strand

Genomic View for RPL27A Gene

Genes around RPL27A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL27A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL27A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL27A Gene

Proteins for RPL27A Gene

  • Protein details for RPL27A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L27a
    Protein Accession:
    Secondary Accessions:
    • B2R4B3

    Protein attributes for RPL27A Gene

    148 amino acids
    Molecular mass:
    16561 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL27A Gene

neXtProt entry for RPL27A Gene

Post-translational modifications for RPL27A Gene

  • Hydroxylated on His-39 by MINA.
  • Ubiquitination at isoforms=47, Lys55, Lys77, and isoforms=92
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL27A Gene

Domains & Families for RPL27A Gene

Gene Families for RPL27A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL27A Gene

Suggested Antigen Peptide Sequences for RPL27A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL15 family.
  • Belongs to the universal ribosomal protein uL15 family.
genes like me logo Genes that share domains with RPL27A: view

Function for RPL27A Gene

Molecular function for RPL27A Gene

GENATLAS Biochemistry:
60S ribosomal protein L27A,16kDa

Phenotypes From GWAS Catalog for RPL27A Gene

Gene Ontology (GO) - Molecular Function for RPL27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IDA 22681889
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with RPL27A: view
genes like me logo Genes that share phenotypes with RPL27A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL27A Gene

Localization for RPL27A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL27A gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol IDA,TAS --
GO:0005840 ribosome IEA --
GO:0015934 large ribosomal subunit IEA --
genes like me logo Genes that share ontologies with RPL27A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL27A Gene

Pathways & Interactions for RPL27A Gene

genes like me logo Genes that share pathways with RPL27A: view

Pathways by source for RPL27A Gene

1 KEGG pathway for RPL27A Gene
1 GeneGo (Thomson Reuters) pathway for RPL27A Gene

Gene Ontology (GO) - Biological Process for RPL27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL27A: view

No data available for SIGNOR curated interactions for RPL27A Gene

Drugs & Compounds for RPL27A Gene

No Compound Related Data Available

Transcripts for RPL27A Gene

Unigene Clusters for RPL27A Gene

Ribosomal protein L27a:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL27A Gene

No ASD Table

Relevant External Links for RPL27A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL27A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL27A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL27A Gene

Protein tissue co-expression partners for RPL27A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL27A Gene:


SOURCE GeneReport for Unigene cluster for RPL27A Gene:


Evidence on tissue expression from TISSUES for RPL27A Gene

  • Intestine(4.9)
  • Kidney(4.8)
  • Lung(4.7)
  • Nervous system(4.6)
  • Heart(4.3)
  • Skin(4)
  • Eye(3.9)
  • Liver(3.9)
  • Pancreas(3.8)
  • Spleen(2.8)
  • Thyroid gland(2.8)
  • Blood(2.6)
  • Lymph node(2.6)
  • Muscle(2.6)
  • Bone(2.5)
  • Bone marrow(2.5)
  • Adrenal gland(2.4)
  • Stomach(2.3)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with RPL27A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL27A Gene

Orthologs for RPL27A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL27A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL27A 33 34
  • 99.77 (n)
(Bos Taurus)
Mammalia -- 34
  • 97 (a)
RPL27A 33
  • 92.12 (n)
(Mus musculus)
Mammalia Gm7536 34
  • 97 (a)
Rpl27a 33 16 34
  • 90.99 (n)
(Monodelphis domestica)
Mammalia RPL27A 34
  • 95 (a)
(Canis familiaris)
Mammalia RPL27A 33 34
  • 90.99 (n)
(Rattus norvegicus)
Mammalia Rpl27a 33
  • 88.96 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
(Gallus gallus)
Aves RPL27A 33 34
  • 80.18 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 91 (a)
-- 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl27a 33
  • 77.03 (n)
Str.14185 33
(Danio rerio)
Actinopterygii rpl27a 33
  • 75.23 (n)
wufa93g12 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8028 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011706 33
  • 67.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL27A 33 34 35
  • 66.67 (n)
(Caenorhabditis elegans)
Secernentea Y37E3.8a 35
  • 69 (a)
Y37E3.8 33 34
  • 65.52 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL035C 33
  • 63.06 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06831g 33
  • 61.71 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL28 34 36 33
  • 60.59 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G70600 33
  • 68.28 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.184 33
(Oryza sativa)
Liliopsida Os03g0408300 33
  • 63.91 (n)
(Zea mays)
Liliopsida Zm.16909 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6935 34
  • 79 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2801 33
  • 61.26 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03806 33
  • 61.19 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2593 33
Species where no ortholog for RPL27A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL27A Gene

Gene Tree for RPL27A (if available)
Gene Tree for RPL27A (if available)

Paralogs for RPL27A Gene

(4) SIMAP similar genes for RPL27A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RPL27A: view

No data available for Paralogs for RPL27A Gene

Variants for RPL27A Gene

Sequence variations from dbSNP and Humsavar for RPL27A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000036465 -- 8,681,402(+) TGCTG(A/G)GATTA intron-variant, upstream-variant-2KB
rs1000488056 -- 8,681,369(+) ACCTC(A/G)TGATC intron-variant, upstream-variant-2KB
rs1001394543 -- 8,684,284(+) TCCTC(A/G)AAGAG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1001578248 -- 8,681,132(+) TTTGG(-/A)AATTT intron-variant, upstream-variant-2KB
rs1002378478 -- 8,685,051(+) TAGCA(C/G)TGCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL27A Gene

Variant ID Type Subtype PubMed ID
nsv975880 CNV duplication 23825009
nsv7215 OTHER inversion 18451855
nsv499766 OTHER inversion 21111241

Variation tolerance for RPL27A Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL27A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL27A Gene

Disorders for RPL27A Gene

Relevant External Links for RPL27A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL27A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL27A Gene

Publications for RPL27A Gene

  1. Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A. (PMID: 10449908) Kusuda J … Hashimoto K (Cytogenetics and cell genetics 1999) 3 4 22 60
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 60
  3. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio JM … Iovanna JL (Biochimica et biophysica acta 1995) 2 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for RPL27A Gene

Sources for RPL27A Gene

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