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Aliases for RPL27 Gene

Aliases for RPL27 Gene

  • Ribosomal Protein L27 2 3 5
  • 60S Ribosomal Protein L27 2
  • L27 3

External Ids for RPL27 Gene

Previous GeneCards Identifiers for RPL27 Gene

  • GC17P040721
  • GC17P043312
  • GC17P041059
  • GC17P041523
  • GC17P038403
  • GC17P041150
  • GC17P036916

Summaries for RPL27 Gene

Entrez Gene Summary for RPL27 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L27E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL27 Gene

RPL27 (Ribosomal Protein L27) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL27 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL27 Gene

Genomics for RPL27 Gene

Regulatory Elements for RPL27 Gene

Enhancers for RPL27 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPL27 on UCSC Golden Path with GeneCards custom track

Promoters for RPL27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL27 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL27 Gene

42,998,273 bp from pter
43,002,959 bp from pter
4,687 bases
Plus strand

Genomic View for RPL27 Gene

Genes around RPL27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL27 Gene

Proteins for RPL27 Gene

  • Protein details for RPL27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L27
    Protein Accession:
    Secondary Accessions:
    • P08526
    • Q4G0A9

    Protein attributes for RPL27 Gene

    136 amino acids
    Molecular mass:
    15798 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL27 Gene

neXtProt entry for RPL27 Gene

Proteomics data for RPL27 Gene at MOPED

Post-translational modifications for RPL27 Gene

  • Ubiquitination at Lys 9, Lys 73, Lys 98, Lys 128, and Lys 133
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL27 Gene

No data available for DME Specific Peptides for RPL27 Gene

Domains & Families for RPL27 Gene

Gene Families for RPL27 Gene

Protein Domains for RPL27 Gene

Suggested Antigen Peptide Sequences for RPL27 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KOW domain.
  • Belongs to the ribosomal protein L27e family.
  • Contains 1 KOW domain.
  • Belongs to the ribosomal protein L27e family.
genes like me logo Genes that share domains with RPL27: view

Function for RPL27 Gene

Molecular function for RPL27 Gene

GENATLAS Biochemistry:
60S ribosomal protein L27 (fetal kidney),gene or like sequence
genes like me logo Genes that share phenotypes with RPL27: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL27 Gene

Localization for RPL27 Gene

Subcellular locations from

Jensen Localization Image for RPL27 Gene COMPARTMENTS Subcellular localization image for RPL27 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 2
chloroplast 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA,TAS 8148381
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL27 Gene

Pathways & Interactions for RPL27 Gene

genes like me logo Genes that share pathways with RPL27: view

Pathways by source for RPL27 Gene

1 KEGG pathway for RPL27 Gene
1 GeneGo (Thomson Reuters) pathway for RPL27 Gene

Gene Ontology (GO) - Biological Process for RPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with RPL27: view

No data available for SIGNOR curated interactions for RPL27 Gene

Drugs & Compounds for RPL27 Gene

(1) Additional Compounds for RPL27 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPL27: view

Transcripts for RPL27 Gene

Unigene Clusters for RPL27 Gene

Ribosomal protein L27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL27 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for RPL27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL27 Gene

mRNA expression in normal human tissues for RPL27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL27 Gene

This gene is overexpressed in Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL27 Gene

SOURCE GeneReport for Unigene cluster for RPL27 Gene Hs.514196

genes like me logo Genes that share expression patterns with RPL27: view

Protein tissue co-expression partners for RPL27 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL27 Gene

Orthologs for RPL27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL27 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL27 35
  • 92.4 (n)
  • 100 (a)
-- 36
  • 68 (a)
RPL27 36
  • 100 (a)
(Canis familiaris)
Mammalia RPL27 35
  • 93.63 (n)
  • 100 (a)
-- 36
  • 86 (a)
RPL27 36
  • 95 (a)
RPL27 36
  • 100 (a)
(Mus musculus)
Mammalia Rpl27 35
  • 90.2 (n)
  • 100 (a)
Rpl27 16
Gm4825 36
  • 86 (a)
Rpl27 36
  • 100 (a)
Rpl27-ps3 36
  • 100 (a)
(Pan troglodytes)
Mammalia RPL27 35
  • 100 (n)
  • 100 (a)
RPL27 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rpl27 35
  • 90.69 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
-- 36
  • 99 (a)
(Gallus gallus)
Aves RPL27 35
  • 84.31 (n)
  • 100 (a)
RPL27 36
  • 100 (a)
(Anolis carolinensis)
Reptilia RPL27 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl27 35
  • 81.62 (n)
  • 95.59 (a)
Str.17062 35
African clawed frog
(Xenopus laevis)
Amphibia rpl27-prov 35
(Danio rerio)
Actinopterygii rpl27 35
  • 84.31 (n)
  • 95.59 (a)
wufc93a08 35
rpl27 36
  • 96 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8426 35
fruit fly
(Drosophila melanogaster)
Insecta CG4759 37
  • 62 (a)
RpL27 35
  • 64.18 (n)
  • 63.43 (a)
RpL27 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011687 35
  • 65.43 (n)
  • 67.41 (a)
(Caenorhabditis elegans)
Secernentea rpl-27 37
  • 69 (a)
rpl-27 35
  • 65.69 (n)
  • 69.12 (a)
rpl-27 36
  • 69 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR413C 35
  • 57.6 (n)
  • 53.68 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03455g 35
  • 58.58 (n)
  • 55.88 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL27A 35
  • 57.84 (n)
  • 55.88 (a)
RPL27A 36
  • 56 (a)
RPL27B 36
  • 56 (a)
RPL27B 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G32220 35
  • 57.78 (n)
  • 57.78 (a)
(Oryza sativa)
Liliopsida Os02g0284600 35
  • 57.6 (n)
  • 52.21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1774 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01827 35
  • 53.48 (n)
  • 49.25 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2702 35
  • 52.7 (n)
  • 52.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7870 36
  • 76 (a)
Species with no ortholog for RPL27:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL27 Gene

Gene Tree for RPL27 (if available)
Gene Tree for RPL27 (if available)

Paralogs for RPL27 Gene

genes like me logo Genes that share paralogs with RPL27: view

No data available for Paralogs for RPL27 Gene

Variants for RPL27 Gene

Sequence variations from dbSNP and Humsavar for RPL27 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs690936 -- 43,001,948(-) atgcc(C/T)ggcta intron-variant
rs691697 -- 42,999,874(-) TGTTA(G/T)AGGTA intron-variant
rs691711 -- 42,999,726(-) GCTTA(C/T)TAGAG intron-variant
rs691954 -- 42,998,966(-) CAAAA(A/G)CTCTC intron-variant
rs691997 -- 42,998,504(-) GCAGC(A/C/G)GATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL27 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv483009 CNV Gain 15286789
nsv457742 CNV Loss 19166990
esv2672913 CNV Deletion 23128226
esv2668416 CNV Deletion 23128226

Variation tolerance for RPL27 Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL27 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL27 Gene

Disorders for RPL27 Gene

Relevant External Links for RPL27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL27 Gene

Publications for RPL27 Gene

  1. Cloning and nucleotide sequence of a full length cDNA encoding ribosomal protein L27 from human fetal kidney. (PMID: 8148381) Gallagher R.A. … Malik A.N. (Biochim. Biophys. Acta 1994) 3 4 23 67
  2. Generation of region- and species-specific expressed gene probes from somatic cell hybrids. (PMID: 1302024) Jones K.W. … Fournier R.E. (Nat. Genet. 1992) 2 3
  3. Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. (PMID: 26561776) Verrastro I. … Pitt A.R. (Free Radic. Biol. Med. 2016) 3
  4. Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia. (PMID: 25424902) Wang R. … Ito E. (Br. J. Haematol. 2015) 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for RPL27 Gene

Sources for RPL27 Gene