Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPL27 Gene

Aliases for RPL27 Gene

  • Ribosomal Protein L27 2 3
  • 60S Ribosomal Protein L27 2 3
  • L27 3

External Ids for RPL27 Gene

Previous GeneCards Identifiers for RPL27 Gene

  • GC17P040721
  • GC17P043312
  • GC17P041059
  • GC17P041523
  • GC17P038403
  • GC17P041150
  • GC17P036916

Summaries for RPL27 Gene

Entrez Gene Summary for RPL27 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L27E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL27 Gene

RPL27 (Ribosomal Protein L27) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPL27 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL27 Gene

Genomics for RPL27 Gene

Regulatory Elements for RPL27 Gene

Genomic Location for RPL27 Gene

42,998,273 bp from pter
43,002,959 bp from pter
4,687 bases
Plus strand

Genomic View for RPL27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL27 Gene

Proteins for RPL27 Gene

  • Protein details for RPL27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L27
    Protein Accession:
    Secondary Accessions:
    • P08526
    • Q4G0A9

    Protein attributes for RPL27 Gene

    136 amino acids
    Molecular mass:
    15798 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL27 Gene

neXtProt entry for RPL27 Gene

Proteomics data for RPL27 Gene at MOPED

Post-translational modifications for RPL27 Gene

  • Ubiquitination at Lys9, Lys27, Lys73, Lys93, Lys98, Lys128, and Lys133
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL27 Gene

Antibody Products

No data available for DME Specific Peptides for RPL27 Gene

Domains for RPL27 Gene

Gene Families for RPL27 Gene

  • RPL :L ribosomal proteins

Protein Domains for RPL27 Gene

Suggested Antigen Peptide Sequences for RPL27 Gene

Graphical View of Domain Structure for InterPro Entry



  • P61353
  • Contains 1 KOW domain.
  • Belongs to the ribosomal protein L27e family.
genes like me logo Genes that share domains with RPL27: view

Function for RPL27 Gene

Molecular function for RPL27 Gene

GENATLAS Biochemistry:
60S ribosomal protein L27 (fetal kidney),gene or like sequence

Gene Ontology (GO) - Molecular Function for RPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome TAS 8148381
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL27: view
genes like me logo Genes that share phenotypes with RPL27: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL27

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL27 Gene

Localization for RPL27 Gene

Subcellular locations from

Jensen Localization Image for RPL27 Gene COMPARTMENTS Subcellular localization image for RPL27 gene
Compartment Confidence
cytosol 5
mitochondrion 2
chloroplast 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0005840 ribosome TAS 8148381
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with RPL27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL27 Gene

Pathways for RPL27 Gene

genes like me logo Genes that share pathways with RPL27: view

Pathways by source for RPL27 Gene

1 KEGG pathway for RPL27 Gene
1 GeneGo (Thomson Reuters) pathway for RPL27 Gene

Gene Ontology (GO) - Biological Process for RPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL27: view

Compounds for RPL27 Gene

(1) Novoseek inferred chemical compound relationships for RPL27 Gene

Compound -log(P) Hits PubMed IDs
creatinine 25.5 3
genes like me logo Genes that share compounds with RPL27: view

Transcripts for RPL27 Gene

mRNA/cDNA for RPL27 Gene

Unigene Clusters for RPL27 Gene

Ribosomal protein L27:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL27

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL27 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for RPL27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL27 Gene

mRNA expression in normal human tissues for RPL27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RPL27 Gene

This gene is overexpressed in Ovary (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL27 Gene

SOURCE GeneReport for Unigene cluster for RPL27 Gene Hs.514196

genes like me logo Genes that share expressions with RPL27: view

Expression partners for RPL27 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL27 Gene

Orthologs for RPL27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL27 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL27 35
  • 92.4 (n)
  • 100 (a)
-- 36
  • 68 (a)
RPL27 36
  • 100 (a)
(Canis familiaris)
Mammalia RPL27 35
  • 93.63 (n)
  • 100 (a)
-- 36
  • 86 (a)
RPL27 36
  • 95 (a)
RPL27 36
  • 100 (a)
(Mus musculus)
Mammalia Rpl27 35
  • 90.2 (n)
  • 100 (a)
Rpl27 16
Gm4825 36
  • 86 (a)
Rpl27 36
  • 100 (a)
Rpl27-ps3 36
  • 100 (a)
(Pan troglodytes)
Mammalia RPL27 35
  • 100 (n)
  • 100 (a)
RPL27 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rpl27 35
  • 90.69 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
-- 36
  • 99 (a)
(Gallus gallus)
Aves RPL27 35
  • 84.31 (n)
  • 100 (a)
RPL27 36
  • 100 (a)
(Anolis carolinensis)
Reptilia RPL27 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl27 35
  • 81.62 (n)
  • 95.59 (a)
Str.17062 35
African clawed frog
(Xenopus laevis)
Amphibia rpl27-prov 35
(Danio rerio)
Actinopterygii rpl27 35
  • 84.31 (n)
  • 95.59 (a)
wufc93a08 35
rpl27 36
  • 96 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8426 35
fruit fly
(Drosophila melanogaster)
Insecta CG4759 37
  • 62 (a)
RpL27 35
  • 64.18 (n)
  • 63.43 (a)
RpL27 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011687 35
  • 65.43 (n)
  • 67.41 (a)
(Caenorhabditis elegans)
Secernentea rpl-27 37
  • 69 (a)
rpl-27 35
  • 65.69 (n)
  • 69.12 (a)
rpl-27 36
  • 69 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR413C 35
  • 57.6 (n)
  • 53.68 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03455g 35
  • 58.58 (n)
  • 55.88 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL27A 35
  • 57.84 (n)
  • 55.88 (a)
RPL27A 36
  • 56 (a)
RPL27B 36
  • 56 (a)
RPL27B 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G32220 35
  • 57.78 (n)
  • 57.78 (a)
(Oryza sativa)
Liliopsida Os02g0284600 35
  • 57.6 (n)
  • 52.21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1774 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01827 35
  • 53.48 (n)
  • 49.25 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2702 35
  • 52.7 (n)
  • 52.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7870 36
  • 76 (a)
Species with no ortholog for RPL27:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL27 Gene

Gene Tree for RPL27 (if available)
Gene Tree for RPL27 (if available)

Paralogs for RPL27 Gene

genes like me logo Genes that share paralogs with RPL27: view

No data available for Paralogs for RPL27 Gene

Variants for RPL27 Gene

Sequence variations from dbSNP and Humsavar for RPL27 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs323505 -- 42,997,692(+) TCTCT(C/T)TAAGC upstream-variant-2KB
rs323506 -- 42,997,053(+) atcac(A/G)agccc upstream-variant-2KB
rs690936 -- 43,001,948(-) atgcc(C/T)ggcta intron-variant
rs691697 -- 42,999,874(-) TGTTA(G/T)AGGTA intron-variant
rs691711 -- 42,999,726(-) GCTTA(C/T)TAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL27 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv483009 CNV Gain 15286789
nsv457742 CNV Loss 19166990
esv2672913 CNV Deletion 23128226
esv2668416 CNV Deletion 23128226

Relevant External Links for RPL27 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL27 Gene

Disorders for RPL27 Gene

No disorders were found for RPL27 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RPL27 Gene

Publications for RPL27 Gene

  1. Cloning and nucleotide sequence of a full length cDNA encoding ribosomal protein L27 from human fetal kidney. (PMID: 8148381) Gallagher R.A. … Malik A.N. (Biochim. Biophys. Acta 1994) 3 4 23
  2. Generation of region- and species-specific expressed gene probes from somatic cell hybrids. (PMID: 1302024) Jones K.W. … Fournier R.E. (Nat. Genet. 1992) 2 3
  3. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Nucleolar proteome dynamics. (PMID: 15635413) Andersen J.S. … Mann M. (Nature 2005) 3

Products for RPL27 Gene

Sources for RPL27 Gene

Back to Top