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Aliases for RPL27 Gene

Aliases for RPL27 Gene

  • Ribosomal Protein L27 2 3 5
  • 60S Ribosomal Protein L27 2 3
  • L27 3

External Ids for RPL27 Gene

Previous GeneCards Identifiers for RPL27 Gene

  • GC17P040721
  • GC17P043312
  • GC17P041059
  • GC17P041523
  • GC17P038403
  • GC17P041150
  • GC17P036916

Summaries for RPL27 Gene

Entrez Gene Summary for RPL27 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L27E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL27 Gene

RPL27 (Ribosomal Protein L27) is a Protein Coding gene. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL27 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL27 Gene

Genomics for RPL27 Gene

Regulatory Elements for RPL27 Gene

Enhancers for RPL27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F043322 1.5 Ensembl ENCODE 22.8 +324.9 324898 1.7 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 ENSG00000267340 ENSG00000267002 ASB16-AS1 HMGN1P29 DHX8 NBR2 LOC108783654 LINC00910 AOC3 ENSG00000260793
GH17F042997 1.5 Ensembl ENCODE 19.2 +1.7 1676 5.2 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC DHX8 NBR2 ENSG00000267758 LINC00910 HMGN1P29 HMGN2P15 NAGLU ENSG00000267604 RPL27 FAM134C
GH17F042832 1.1 ENCODE 24.1 -164.6 -164632 3.1 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 RPL27 AOC4P MEOX1 NAGLU ENSG00000212149 AOC3 PTGES3L-AARSD1 CNTD1 COA3 LOC108783654
GH17F042405 1.7 FANTOM5 Ensembl ENCODE 12.3 -589.2 -589187 6.6 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 NAGLU ENSG00000267002 HSD17B1 RPL27 AOC3 ENSG00000267340 KAT2A AOC4P ENSG00000267221 STAT3
GH17F043481 1.2 ENCODE 15.5 +485.4 485421 3.5 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A ZNF2 YY1 ETV4 RPL27 RAMP2-AS1 HMGN2P15 NAGLU AOC3 MIR2117 RAMP2 AOC4P DHX8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL27 on UCSC Golden Path with GeneCards custom track

Promoters for RPL27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001346742 527 2001 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for RPL27 Gene

Chromosome:
17
Start:
42,998,273 bp from pter
End:
43,002,959 bp from pter
Size:
4,687 bases
Orientation:
Plus strand

Genomic View for RPL27 Gene

Genes around RPL27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL27 Gene

Proteins for RPL27 Gene

  • Protein details for RPL27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61353-RL27_HUMAN
    Recommended name:
    60S ribosomal protein L27
    Protein Accession:
    P61353
    Secondary Accessions:
    • P08526
    • Q4G0A9

    Protein attributes for RPL27 Gene

    Size:
    136 amino acids
    Molecular mass:
    15798 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL27 Gene

neXtProt entry for RPL27 Gene

Post-translational modifications for RPL27 Gene

  • Ubiquitination at Lys 9, Lys 73, Lys 98, Lys 128, and Lys 133
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL27 Gene

No data available for DME Specific Peptides for RPL27 Gene

Domains & Families for RPL27 Gene

Gene Families for RPL27 Gene

Suggested Antigen Peptide Sequences for RPL27 Gene

Graphical View of Domain Structure for InterPro Entry

P61353

UniProtKB/Swiss-Prot:

RL27_HUMAN :
  • Contains 1 KOW domain.
  • Belongs to the ribosomal protein L27e family.
Domain:
  • Contains 1 KOW domain.
Family:
  • Belongs to the ribosomal protein L27e family.
genes like me logo Genes that share domains with RPL27: view

Function for RPL27 Gene

Molecular function for RPL27 Gene

GENATLAS Biochemistry:
60S ribosomal protein L27 (fetal kidney),gene or like sequence

Gene Ontology (GO) - Molecular Function for RPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA,TAS 8148381
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL27: view
genes like me logo Genes that share phenotypes with RPL27: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL27 Gene

Localization for RPL27 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL27 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA,TAS 8148381
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with RPL27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL27 Gene

Pathways & Interactions for RPL27 Gene

genes like me logo Genes that share pathways with RPL27: view

Pathways by source for RPL27 Gene

1 KEGG pathway for RPL27 Gene
1 GeneGo (Thomson Reuters) pathway for RPL27 Gene

Gene Ontology (GO) - Biological Process for RPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL27: view

No data available for SIGNOR curated interactions for RPL27 Gene

Drugs & Compounds for RPL27 Gene

(1) Additional Compounds for RPL27 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPL27: view

Transcripts for RPL27 Gene

Unigene Clusters for RPL27 Gene

Ribosomal protein L27:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL27 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for RPL27 Gene

GeneLoc Exon Structure for
RPL27
ECgene alternative splicing isoforms for
RPL27

Expression for RPL27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL27 Gene

This gene is overexpressed in Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL27 Gene



Protein tissue co-expression partners for RPL27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL27 Gene:

RPL27

SOURCE GeneReport for Unigene cluster for RPL27 Gene:

Hs.514196
genes like me logo Genes that share expression patterns with RPL27: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL27 Gene

Orthologs for RPL27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL27 34 35
  • 100 (n)
mouse
(Mus musculus)
Mammalia Rpl27-ps3 35
  • 100 (a)
OneToMany
Rpl27 34 16 35
  • 90.2 (n)
Gm4825 35
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPL27 34 35 35
  • 93.63 (n)
-- 35
  • 86 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPL27 34 35
  • 92.4 (n)
-- 35
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rpl27 34
  • 90.69 (n)
chicken
(Gallus gallus)
Aves RPL27 34 35
  • 84.31 (n)
lizard
(Anolis carolinensis)
Reptilia RPL27 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl27 34
  • 81.62 (n)
Str.17062 34
African clawed frog
(Xenopus laevis)
Amphibia rpl27-prov 34
zebrafish
(Danio rerio)
Actinopterygii rpl27 34 35
  • 84.31 (n)
wufc93a08 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8426 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011687 34
  • 65.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL27 34 35
  • 64.18 (n)
CG4759 36
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-27 36 34 35
  • 65.69 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03455g 34
  • 58.58 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL27A 34 35
  • 57.84 (n)
RPL27B 35 37
  • 56 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR413C 34
  • 57.6 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G32220 34
  • 57.78 (n)
rice
(Oryza sativa)
Liliopsida Os02g0284600 34
  • 57.6 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7870 35
  • 76 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU01827 34
  • 53.48 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2702 34
  • 52.7 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1774 34
Species where no ortholog for RPL27 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL27 Gene

ENSEMBL:
Gene Tree for RPL27 (if available)
TreeFam:
Gene Tree for RPL27 (if available)

Paralogs for RPL27 Gene

No data available for Paralogs for RPL27 Gene

Variants for RPL27 Gene

Sequence variations from dbSNP and Humsavar for RPL27 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10551222 -- 43,002,342(+) AAAAA(-/AA)TACAA intron-variant
rs10648593 -- 42,996,799(+) AAAAA(-/A/AA/AAA/AAAA)TTGTA upstream-variant-2KB
rs10648594 -- 42,996,944(+) AAAAA(-/AAA/AAAA/AAAAA)GTTCT upstream-variant-2KB
rs10699371 -- 43,001,469(+) AAAAA(-/TAAAAA)AATTA intron-variant
rs111280948 -- 43,001,470(+) AAAAA(A/T)ATTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL27 Gene

Variant ID Type Subtype PubMed ID
esv2668416 CNV deletion 23128226
esv2672913 CNV deletion 23128226
esv33998 OTHER inversion 15654335
esv3640618 CNV loss 21293372
nsv1146669 OTHER inversion 26484159
nsv457742 CNV loss 19166990
nsv483009 CNV gain 15286789
nsv575052 CNV loss 21841781

Variation tolerance for RPL27 Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL27 Gene

Human Gene Mutation Database (HGMD)
RPL27
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL27 Gene

Disorders for RPL27 Gene

Relevant External Links for RPL27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL27

No disorders were found for RPL27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL27 Gene

Publications for RPL27 Gene

  1. Cloning and nucleotide sequence of a full length cDNA encoding ribosomal protein L27 from human fetal kidney. (PMID: 8148381) Gallagher R.A. … Malik A.N. (Biochim. Biophys. Acta 1994) 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4 64
  4. Generation of region- and species-specific expressed gene probes from somatic cell hybrids. (PMID: 1302024) Jones K.W. … Fournier R.E. (Nat. Genet. 1992) 2 3 64
  5. The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. (PMID: 26549023) Zhou L. … Hanemann C.O. (Oncogene 2016) 3 64

Products for RPL27 Gene

Sources for RPL27 Gene

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