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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL26L1 Gene

protein-coding   GIFtS: 53
GCID: GC05P172385

ribosomal protein L26-like 1

(Previous name: ribosomal protein L26 pseudogene 1 )
(Previous symbol: RPL26P1)
 Explore 4 diseases affiliated with
RPL26L1 via our new
 Human Malady Compendium 
Biological research products
for RPL26L1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ribosomal Protein L26-Like 11 2
RPL26P11 2 3
Ribosomal Protein L26 Pseudogene 11 2
60S Ribosomal Protein L26-Like 12
Ribosomal Protein L26 Homolog2

External Ids:    HGNC: 170501   Entrez Gene: 511212   Ensembl: ENSG000000372417   UniProtKB: Q9UNX33   

Export aliases for RPL26L1 gene to outside databases

Previous GC identifers: GC05P172643 GC05P173088 GC05P172316 GC05P172367 GC05P172319 GC05P167481


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL26L1:
This gene encodes a protein that shares high sequence similarity with ribosomal protein L26. It is not currently known
whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent
of the ribosome. Transcript variants utilizing alternative polyA signals exist. (provided by RefSeq, Jul 2008)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL26L1 gene promoter:
         SRF   AML1a   SRF (504 AA)   Nkx2-5   CREB   Pax-3   deltaCREB   STAT3   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL26L1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPL26L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL26L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.2

RPL26L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL26L1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P172385:  view genomic region     (about GC identifiers)

Start:
172,385,732 bp from pter      End:
172,396,774 bp from pter
Size:
11,043 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RL26L_HUMAN, Q9UNX3 (See protein sequence)
Recommended Name: 60S ribosomal protein L26-like 1  
Size: 145 amino acids; 17256 Da
Secondary accessions: B3KY82 D3DQM0

Explore the universe of human proteins at neXtProt for RPL26L1: NX_Q9UNX3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UNX3

  • RPL26L1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057177.1  
    ENSEMBL proteins: 
     ENSP00000428177   ENSP00000428223   ENSP00000265100   ENSP00000430147   ENSP00000429783  
     ENSP00000430673  
    Reactome Protein details: Q9UNX3
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    Uscn Proteins for RPL26L1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0015934large ribosomal subunit IEA--


    RPL26L1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RPL26L1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR014722 Rib_L2_dom2
     IPR005825 Ribosomal_L24/26_CS
     IPR005756 Ribosomal_L26/L24P_euk/arc
     IPR008991 Translation_prot_SH3-like
     IPR005824 KOW

    Graphical View of Domain Structure for InterPro Entry Q9UNX3

    ProtoNet protein and cluster: Q9UNX3

    1 Blocks protein family: IPB006646 KOW (Kyprides

    UniProtKB/Swiss-Prot: RL26L_HUMAN, Q9UNX3
    Similarity: Belongs to the ribosomal protein L24P family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    Inhib. RNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--


    RPL26L1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    8/24 pathways (see all 24)
    Viral Protein Synthesis1.00
    Ribosome0.87
    Viral mRNA Translation1.00
    SMG6 Cleaves mRNA with Premature Termination Codon0.80
    Influenza Viral RNA Transcription and Replication1.00
    L13a-mediated translational silencing of Ceruloplasmin expression0.79
    Synthesis of nascent polypeptide containing signal sequence1.00
    3' -UTR-mediated translational regulation0.79
    2Metabolism of mRNA
    Metabolism of mRNA1.00
    Metabolism of RNA0.92
    3Disease
    Disease1.00
    4Generic Transcription Pathway
    Gene Expression0.46
    5Asparagine N-linked glycosylation
    Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/28        Reactome Pathways for RPL26L1 (see all 28)
        Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Eukaryotic Translation Initiation


    1         Kegg Pathway  (Kegg details for RPL26L1):
        Ribosome


    RPL26L1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL26L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/183 Interacting proteins for RPL26L1 (Q9UNX33 ENSP000002651004) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=2 
    CALM2P621583I2D: score=2 
    CALM3P621583I2D: score=2 
    RPL17P186213, ENSP000003894654I2D: score=1 STRING: ENSP00000389465
    RPL35P427663, ENSP000002594694I2D: score=6 STRING: ENSP00000259469
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--


    RPL26L1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL26L1

    3 DrugBank Compounds for RPL26L1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ANISOMYCIN-- --target--10592235
    Alpha-Hydroxy-Beta-Phenyl-Propionic Acid-- --target--10592235
    PUROMYCIN-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about RPL26L1 / RL26L 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPL26L1 gene: 
    NM_016093.2  

    Unigene Cluster for RPL26L1:

    Ribosomal protein L26-like 1
    Hs.546390  [show with all ESTs]
    Unigene Representative Sequence: CB994949
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519974 ENST00000521476 ENST00000265100(uc003mcc.3) ENST00000519239
    ENST00000519522 ENST00000519156

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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL26L1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL26L1

    Additional cDNA sequence: 

    AF083248.1 AK128872.1 BC017360.2 BC070192.1 

    8 DOTS entries:

    DT.95275024  DT.95275023  DT.75127312  DT.100784311  DT.120800819  DT.120800828  DT.100784312  DT.99939243 

    24/129 AceView cDNA sequences (see all 129):

    AI350075 BQ432293 BQ684711 BC017360 BU193755 BM820632 AK128872 CB111373 
    BU624106 AI085368 BX280748 AI253648 AA704992 AA313166 BX280686 AA460318 
    BM912184 BU163951 AI419260 BM423868 NM_016093 CB111455 BQ015377 BI335849 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RPL26L1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
    SP1:              -                           
    SP2:                                          


    ECgene alternative splicing isoforms for RPL26L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL26L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCATCCGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RPL26L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL26L1

    SOURCE GeneReport for Unigene cluster: Hs.546390
        SABiosciences Custom PCR Arrays for RPL26L1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL26L1 gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RPL26L11 ribosomal protein L26-like 1 82.99(n)
    98.62(a)
      396400  XM_001231498.2  XP_001231499.2 
    lizard
    (Anolis carolinensis)
    Reptilia RPL266
    --
    99(a)
    possible ortholog
    2(124479622-124483576)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420007092   -- 81.63(n)    142000709 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.269562 Danio rerio cDNA clone MGC66190 IMAGE5612305, complete more 77.89(n)    BC055538.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68463 protein biosynthesis structural constituent
    of more
    71(a)   75E4   --
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-263 ribosomal protein L26 like 61(a)   II(8602715-8603469)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G499106
    AT5G675106
    60S ribosomal protein L26-2
    70(a)
    65(a)
    many ↔ many
    many ↔ many
    3(18504256-18504967)
    5(26937813-26938451)
    rice
    (Oryza sativa)
    Liliopsida Os.93172 Oryza sativa (japonica cultivar-group) cDNA clone0 more 78.99(n)    AK121546.1 
            Species with no ortholog for RPL26L1

    ENSEMBL Gene Tree for RPL26L1 (if available)
    TreeFam Gene Tree for RPL26L1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL26L1 gene
    ENSG000002638092  RPL262  
    2 SIMAP similar genes for RPL26L1 using alignment to 3 protein entries:     RL26L_HUMAN (see all proteins):
    KRBA2    RPL26

    RPL26L1 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for RPL26L1
    PGOHUM00000238826 PGOHUM00000259003 PGOHUM00000235186 PGOHUM00000257250


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/248 NCBI SNPs in RPL26L1 are shown (see all 248    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1858025581,2
    --172384529(+) ATGAGC/TAAATG 3 -- int1 us2k10--------
    rs1486927261,2
    --172384550(+) TGAGTA/TAATAA 3 -- int1 us2k10--------
    rs1419088641,2
    --172384606(+) ATAAAC/GAGAAC 3 -- int1 us2k10--------
    rs1145225391,2
    C,F,--172384718(+) CTGACC/TTTTAC 3 -- int1 us2k12Minor allele frequency- T:0.02NA NS 266
    rs1915047711,2
    --172384965(+) GCCCGA/GAATAA 3 -- us2k1 int10--------
    rs1816448301,2
    --172385183(+) AATCGC/TTTGAA 3 -- nc-transcript-variantus2k10--------
    rs1868672251,2
    --172385213(+) GGTGAC/GCCGAG 3 -- us2k1 nc-transcript-variant0--------
    rs342172171,2
    C--172385268(+) TCTCAA/-AAAAA 3 -- us2k1 int11Minor allele frequency- -:0.00NA 2
    rs1921109531,2
    --172385351(+) GATAAA/TCTAAG 3 -- int1 us2k10--------
    rs1398783641,2
    C,F,--172385484(+) AAAGGG/TAGAGT 3 -- nc-transcript-variantint1 us2k11Minor allele frequency- T:0.01NS 150

    HapMap Linkage Disequilibrium report for RPL26L1 (172385732 - 172396774 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RPL26L1: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RPL26L1 for disorders           About GeneDecksing

    4 diseases for RPL26L1:    About MalaCards
    diamond-blackfan anemia    lung cancer    anemia    malaria

    1 disease from the University of Copenhagen DISEASES database for RPL26L1:
    Diamond-Blackfan anemia

    Export disorders for RPL26L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL26L1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with RPL26L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
    4. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51121 HGNC: 17050 AceView: RPL26L1 Ensembl:ENSG00000037241 euGenes: HUgn51121
    ECgene: RPL26L1 Kegg: 51121 H-InvDB: RPL26L1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL26L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPL26L1 gene:
    Search GeneIP for patents involving RPL26L1

    GeneCards and IP:
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