Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPL26 Gene

Aliases for RPL26 Gene

  • Ribosomal Protein L26 2 3 5
  • Large Ribosomal Subunit Protein UL24 3 4
  • 60S Ribosomal Protein L26 3
  • DBA11 3
  • L26 3

External Ids for RPL26 Gene

Previous GeneCards Identifiers for RPL26 Gene

  • GC17M008658
  • GC17M009374
  • GC17M008223
  • GC17M008482
  • GC17M008483
  • GC17M008221
  • GC17M008280
  • GC17M008175

Summaries for RPL26 Gene

Entrez Gene Summary for RPL26 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

GeneCards Summary for RPL26 Gene

RPL26 (Ribosomal Protein L26) is a Protein Coding gene. Diseases associated with RPL26 include Diamond-Blackfan Anemia 11 and Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome. An important paralog of this gene is RPL26L1.

Gene Wiki entry for RPL26 Gene

Additional gene information for RPL26 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL26 Gene

Genomics for RPL26 Gene

Regulatory Elements for RPL26 Gene

Enhancers for RPL26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H007833 1.9 FANTOM5 ENCODE dbSUPER 31.2 +543.5 543518 12.5 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC DVL2 PFAS CTC1 WRAP53 POLR2A CNTROB SNORD10 ENSG00000265749 NLGN2 KDM6B
GH17H008185 1.4 ENCODE dbSUPER 28.7 +194.9 194864 5.8 MLX ZFP64 YY1 ZNF143 SP3 ZC3H11A NFYC ZFP41 SSRP1 GLIS1 DVL2 PFAS CNTROB WRAP53 ENSG00000265749 POLR2A NEURL4 SENP3 CTC1 LOC100996842
GH17H008093 1 ENCODE 33.2 +289.2 289210 0.2 ZNF493 ZFP64 ZNF2 ZNF121 ZNF302 ZNF143 KLF7 ZNF202 SP3 ZC3H11A DVL2 PFAS CTC1 CNTROB WRAP53 POLR2A SNORD10 RPL26 ENSG00000265749 SNORA48
GH17H008172 1.5 ENCODE dbSUPER 19.7 +208.3 208281 5.2 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 ZC3H11A DVL2 POLR2A CNTROB CTC1 WRAP53 PFAS SNORD10 ENSG00000265749 KDM6B PER1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL26 on UCSC Golden Path with GeneCards custom track

Promoters for RPL26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000091002 47 2401 PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207

Genomic Locations for RPL26 Gene

Genomic Locations for RPL26 Gene
5,732 bases
Minus strand

Genomic View for RPL26 Gene

Genes around RPL26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL26 Gene

Proteins for RPL26 Gene

  • Protein details for RPL26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L26
    Protein Accession:
    Secondary Accessions:
    • B2R4F0
    • D3DTR8
    • Q02877
    • Q6IPY2

    Protein attributes for RPL26 Gene

    145 amino acids
    Molecular mass:
    17258 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL26 Gene

neXtProt entry for RPL26 Gene

Post-translational modifications for RPL26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RPL26 Gene

Domains & Families for RPL26 Gene

Gene Families for RPL26 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPL26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL24 family.
  • Belongs to the universal ribosomal protein uL24 family.
genes like me logo Genes that share domains with RPL26: view

Function for RPL26 Gene

Molecular function for RPL26 Gene

GENATLAS Biochemistry:
60S ribosomal protein L26

Phenotypes From GWAS Catalog for RPL26 Gene

Gene Ontology (GO) - Molecular Function for RPL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IDA 22681889
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0005515 protein binding IPI 16213212
GO:0048027 mRNA 5-UTR binding IMP 16213212
genes like me logo Genes that share ontologies with RPL26: view
genes like me logo Genes that share phenotypes with RPL26: view

Human Phenotype Ontology for RPL26 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RPL26

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL26 Gene

Localization for RPL26 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL26 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm IDA 16213212
GO:0005730 nucleolus IDA 16213212
GO:0005737 cytoplasm IDA 16213212
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPL26: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL26 Gene

Pathways & Interactions for RPL26 Gene

genes like me logo Genes that share pathways with RPL26: view

Pathways by source for RPL26 Gene

1 Cell Signaling Technology pathway for RPL26 Gene
1 BioSystems pathway for RPL26 Gene
1 KEGG pathway for RPL26 Gene
1 GeneGo (Thomson Reuters) pathway for RPL26 Gene

Gene Ontology (GO) - Biological Process for RPL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL26: view

No data available for SIGNOR curated interactions for RPL26 Gene

Drugs & Compounds for RPL26 Gene

No Compound Related Data Available

Transcripts for RPL26 Gene

Unigene Clusters for RPL26 Gene

Ribosomal protein L26:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RPL26

Alternative Splicing Database (ASD) splice patterns (SP) for RPL26 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - -
SP8: -

Relevant External Links for RPL26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL26 Gene

Protein differential expression in normal tissues from HIPED for RPL26 Gene

This gene is overexpressed in Hair follicle (7.2) and Pancreas (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL26 Gene

Protein tissue co-expression partners for RPL26 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL26 Gene:


SOURCE GeneReport for Unigene cluster for RPL26 Gene:


Evidence on tissue expression from TISSUES for RPL26 Gene

  • Intestine(4.8)
  • Nervous system(4.7)
  • Lung(4.2)
  • Muscle(4.2)
  • Liver(4.1)
  • Kidney(4)
  • Eye(3.7)
  • Skin(3.6)
  • Pancreas(3.4)
  • Heart(3)
  • Spleen(3)
  • Stomach(3)
  • Bone(2.9)
  • Lymph node(2.7)
  • Bone marrow(2.6)
  • Adrenal gland(2.5)
  • Blood(2.5)
  • Thyroid gland(2.5)
  • Gall bladder(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL26 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • inner ear
  • jaw
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • outer ear
  • skull
  • aorta
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • intestine
  • kidney
  • large intestine
  • pelvis
  • penis
  • ureter
  • urethra
  • urinary bladder
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with RPL26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL26 Gene

Orthologs for RPL26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL26 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia RPL26 34
  • 100 (a)
(Monodelphis domestica)
Mammalia RPL26 34
  • 100 (a)
(Pan troglodytes)
Mammalia RPL26 33 34
  • 99.54 (n)
(Bos Taurus)
Mammalia -- 34
  • 99 (a)
RPL26 33
  • 94.02 (n)
(Mus musculus)
Mammalia Rpl26 33 16 34
  • 87.82 (n)
(Rattus norvegicus)
Mammalia Rpl26 33
  • 87.82 (n)
(Gallus gallus)
Aves RPL26 34
  • 100 (a)
(Anolis carolinensis)
Reptilia RPL26 34
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl26 33
  • 82.53 (n)
(Danio rerio)
Actinopterygii rpl26 33 34
  • 80 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6846 35
  • 72 (a)
RpL26 33 34
  • 67.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002468 33
  • 69.54 (n)
(Caenorhabditis elegans)
Secernentea rpl-26 35 33 34
  • 60.19 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL184C 33
  • 60.63 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05742g 33
  • 59.48 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL26A 33 34
  • 58.33 (n)
RPL26B 34
  • 52 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G49910 33
  • 62.35 (n)
(Oryza sativa)
Liliopsida Os12g0150100 33
  • 63.07 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11213 34 34
  • 74 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03565 33
  • 61.76 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl26 33
  • 59.29 (n)
Species where no ortholog for RPL26 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL26 Gene

Gene Tree for RPL26 (if available)
Gene Tree for RPL26 (if available)

Paralogs for RPL26 Gene

Paralogs for RPL26 Gene

(2) SIMAP similar genes for RPL26 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RPL26: view

Variants for RPL26 Gene

Sequence variations from dbSNP and Humsavar for RPL26 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs397518451 Pathogenic 8,382,190(-) AGACA(-/GA)AGTAC reference, frameshift-variant
rs878854147 Uncertain significance 8,379,846(-) TGCAG(C/T)GGGAA reference, missense
rs1000341371 -- 8,377,729(+) GCTTT(A/T)AATAA intron-variant, upstream-variant-2KB
rs1000390023 -- 8,383,203(+) ACACG(C/G)TGCTT upstream-variant-2KB, utr-variant-5-prime
rs1000610630 -- 8,383,122(+) ATGGC(G/T)GCTGA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL26 Gene

Variant ID Type Subtype PubMed ID
nsv960403 CNV duplication 23825009

Variation tolerance for RPL26 Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL26 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL26 Gene

Disorders for RPL26 Gene

MalaCards: The human disease database

(6) MalaCards diseases for RPL26 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 11
  • dba11
diamond-blackfan anemia
  • diamond-blackfan anemia 1
rpl26-related diamond-blackfan anemia
macrocytic anemia
  • anemia macrocytic
conjunctival cancer
  • conjunctival tumor
- elite association - COSMIC cancer census association via MalaCards
Search RPL26 in MalaCards View complete list of genes associated with diseases


  • Diamond-Blackfan anemia 11 (DBA11) [MIM:614900]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:22431104}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPL26

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL26: view

No data available for Genatlas for RPL26 Gene

Publications for RPL26 Gene

  1. Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6. (PMID: 8479925) Zaman GJ (Nucleic acids research 1993) 2 3 4 60
  2. Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. (PMID: 22431104) Gazda HT … Beggs AH (Human mutation 2012) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for RPL26 Gene

Sources for RPL26 Gene