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Aliases for RPL26 Gene

Aliases for RPL26 Gene

  • Ribosomal Protein L26 2 3
  • DBA11 3 6
  • 60S Ribosomal Protein L26 3
  • L26 3

External Ids for RPL26 Gene

Previous GeneCards Identifiers for RPL26 Gene

  • GC17M008658
  • GC17M009374
  • GC17M008223
  • GC17M008482
  • GC17M008483
  • GC17M008221
  • GC17M008280
  • GC17M008175

Summaries for RPL26 Gene

Entrez Gene Summary for RPL26 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL26 Gene

RPL26 (Ribosomal Protein L26) is a Protein Coding gene. Diseases associated with RPL26 include diamond-blackfan anemia 11 and rpl26-related diamond-blackfan anemia. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome. An important paralog of this gene is RPL26L1.

Gene Wiki entry for RPL26 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL26 Gene

Genomics for RPL26 Gene

Regulatory Elements for RPL26 Gene

Genomic Location for RPL26 Gene

8,377,516 bp from pter
8,383,247 bp from pter
5,732 bases
Minus strand

Genomic View for RPL26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL26 Gene

Proteins for RPL26 Gene

  • Protein details for RPL26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L26
    Protein Accession:
    Secondary Accessions:
    • B2R4F0
    • D3DTR8
    • Q02877
    • Q6IPY2

    Protein attributes for RPL26 Gene

    145 amino acids
    Molecular mass:
    17258 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL26 Gene

neXtProt entry for RPL26 Gene

Proteomics data for RPL26 Gene at MOPED

Post-translational modifications for RPL26 Gene

  • Ubiquitination at Lys36, Lys51, Lys63, Lys69, and Lys103
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL26 Gene

No data available for DME Specific Peptides for RPL26 Gene

Domains for RPL26 Gene

Gene Families for RPL26 Gene

  • RPL :L ribosomal proteins

Suggested Antigen Peptide Sequences for RPL26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P61254
  • Belongs to the ribosomal protein L24P family.
genes like me logo Genes that share domains with RPL26: view

Function for RPL26 Gene

Molecular function for RPL26 Gene

GENATLAS Biochemistry: 60S ribosomal protein L26

Gene Ontology (GO) - Molecular Function for RPL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8479925
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RPL26: view

Phenotypes for RPL26 Gene

genes like me logo Genes that share phenotypes with RPL26: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL26 Gene

Localization for RPL26 Gene

Subcellular locations from

Jensen Localization Image for RPL26 Gene COMPARTMENTS Subcellular localization image for RPL26 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0015934 large ribosomal subunit --
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RPL26: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL26 Gene

Pathways for RPL26 Gene

genes like me logo Genes that share pathways with RPL26: view

Pathways by source for RPL26 Gene

1 Cell Signaling Technology pathway for RPL26 Gene
1 BioSystems pathway for RPL26 Gene
1 KEGG pathway for RPL26 Gene
1 GeneGo (Thomson Reuters) pathway for RPL26 Gene

Gene Ontology (GO) - Biological Process for RPL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing IMP 18697920
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPL26: view

Transcripts for RPL26 Gene

Unigene Clusters for RPL26 Gene

Ribosomal protein L26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL26 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - -
SP8: -

Relevant External Links for RPL26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL26 Gene

mRNA expression in normal human tissues for RPL26 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL26 Gene

SOURCE GeneReport for Unigene cluster for RPL26 Gene Hs.482144

genes like me logo Genes that share expressions with RPL26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL26 Gene

Orthologs for RPL26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL26 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL26 35
  • 99.54 (n)
  • 100 (a)
RPL26 36
  • 100 (a)
(Bos Taurus)
Mammalia -- 36
  • 99 (a)
RPL26 35
  • 94.02 (n)
  • 100 (a)
(Canis familiaris)
Mammalia RPL26 36
  • 100 (a)
(Mus musculus)
Mammalia Rpl26 35
  • 87.82 (n)
  • 100 (a)
Rpl26 16
Rpl26 36
  • 100 (a)
(Monodelphis domestica)
Mammalia RPL26 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rpl26 35
  • 87.82 (n)
  • 100 (a)
(Gallus gallus)
Aves RPL26 36
  • 100 (a)
(Anolis carolinensis)
Reptilia RPL26 36
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl26 35
  • 82.53 (n)
  • 97.93 (a)
(Danio rerio)
Actinopterygii rpl26 35
  • 80 (n)
  • 95.86 (a)
rpl26 36
  • 96 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002468 35
  • 69.54 (n)
  • 79.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL26 35
  • 67.59 (n)
  • 73.79 (a)
RpL26 36
  • 72 (a)
CG6846 37
  • 72 (a)
(Caenorhabditis elegans)
Secernentea rpl-26 35
  • 60.19 (n)
  • 64.03 (a)
rpl-26 36
  • 62 (a)
rpl-26 37
  • 62 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL184C 35
  • 60.63 (n)
  • 62.93 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL26A 35
  • 58.33 (n)
  • 55.17 (a)
RPL26A 36
  • 52 (a)
RPL26B 36
  • 52 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05742g 35
  • 59.48 (n)
  • 57.76 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G49910 35
  • 62.35 (n)
  • 73.38 (a)
(Oryza sativa)
Liliopsida Os12g0150100 35
  • 63.07 (n)
  • 68.35 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03565 35
  • 61.76 (n)
  • 65.12 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl26 35
  • 59.29 (n)
  • 59.84 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11213 36
  • 74 (a)
CSA.11213 36
  • 74 (a)
Species with no ortholog for RPL26:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL26 Gene

Gene Tree for RPL26 (if available)
Gene Tree for RPL26 (if available)

Paralogs for RPL26 Gene

Paralogs for RPL26 Gene

Selected SIMAP similar genes for RPL26 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RPL26: view

Variants for RPL26 Gene

Sequence variations from dbSNP and Humsavar for RPL26 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs365897 -- 8,380,168(+) ACCTA(C/G)TGCTA intron-variant
rs393311 -- 8,381,654(+) cgggc(A/G)cggtg intron-variant
rs409445 -- 8,380,061(+) GCCCA(C/G)TTCGG intron-variant
rs422679 -- 8,382,080(+) CAATC(C/T)CTCTT intron-variant
rs3094298 -- 8,382,685(-) AACGT(A/G)AGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL26 Gene

Variant ID Type Subtype PubMed ID
dgv3057n71 CNV Loss 21882294

Relevant External Links for RPL26 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL26 Gene

Disorders for RPL26 Gene

(1) OMIM Diseases for RPL26 Gene (603704)


  • Diamond-Blackfan anemia 11 (DBA11) [MIM:614900]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:22431104}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for RPL26 Gene

genes like me logo Genes that share disorders with RPL26: view

Publications for RPL26 Gene

  1. Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6. (PMID: 8479925) Zaman G.J.R. (Nucleic Acids Res. 1993) 2 3 4
  2. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. (PMID: 22431104) Gazda H.T. … Beggs A.H. (Hum. Mutat. 2012) 3 4
  5. Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA. (PMID: 22433872) Chen J. … Kastan M.B. (J. Biol. Chem. 2012) 3

Products for RPL26 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RPL26
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RPL26
    • Block miRNA regulation of RPL26 using miScript Target Protectors
    • Addgene plasmids for RPL26

    Sources for RPL26 Gene

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