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Aliases for RPL23A Gene

Aliases for RPL23A Gene

  • Ribosomal Protein L23a 2 3 5
  • Large Ribosomal Subunit Protein UL23 3 4
  • Melanoma Differentiation-Associated Gene 20 3
  • 60S Ribosomal Protein L23a 3
  • MDA20 3
  • L23a 3

External Ids for RPL23A Gene

Previous GeneCards Identifiers for RPL23A Gene

  • GC17P026892
  • GC17P028946
  • GC17P027192
  • GC17P024072
  • GC17P027046

Summaries for RPL23A Gene

Entrez Gene Summary for RPL23A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL23A Gene

RPL23A (Ribosomal Protein L23a) is a Protein Coding gene. Diseases associated with RPL23A include Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL23A Gene

  • This protein binds to a specific region on the 26S rRNA.

Gene Wiki entry for RPL23A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL23A Gene

Genomics for RPL23A Gene

Regulatory Elements for RPL23A Gene

Enhancers for RPL23A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G028863 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +145.9 145944 3.3 HDGF CREB3L1 ARNT ARID4B ZNF766 CBX5 FOS KLF13 JUNB REST DHRS13 PROCA1 FLOT2 NEK8 TLCD1 SNORD4B SNORD42A SNORD42B RAB34 RPL23A
GH17G028715 1.7 Ensembl ENCODE dbSUPER 11.8 +3.5 3531 14.4 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 PROCA1 SARM1 ANKRD13B ENSG00000264577 SDF2 TMEM199 NEK8 NUFIP2 RPL23A ENSG00000265474
GH17G029290 1.8 FANTOM5 ENCODE dbSUPER 11.1 +573.9 573873 4.8 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF263 SP3 NFYC TBX21 MEF2D ENSG00000264577 MYO18A SDF2 NUFIP2 TMEM199 NEK8 ANKRD13B SARM1 ENSG00000265474 RPL23A
GH17G028944 1.7 FANTOM5 ENCODE dbSUPER 11.1 +229.9 229946 8.9 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ENSG00000264577 SDF2 TMEM199 NUFIP2 PHF12 RPL23A ANKRD13B ENSG00000258472 TAOK1 MYO18A
GH17G028760 1.5 Ensembl ENCODE dbSUPER 11.8 +41.9 41879 2.2 CREB3L1 ARNT SIN3A YBX1 ETS1 ZNF766 ELK1 KLF13 ZNF592 MEF2D TRAF4 TLCD1 NEK8 SNORD42A SNORD4B ERAL1 FAM222B SNORD4A RAB34 RPL23A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL23A on UCSC Golden Path with GeneCards custom track

Promoters for RPL23A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092756 907 2201 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for RPL23A Gene

Chromosome:
17
Start:
28,719,393 bp from pter
End:
28,724,359 bp from pter
Size:
4,967 bases
Orientation:
Plus strand

Genomic View for RPL23A Gene

Genes around RPL23A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL23A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL23A Gene

Proteins for RPL23A Gene

  • Protein details for RPL23A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62750-RL23A_HUMAN
    Recommended name:
    60S ribosomal protein L23a
    Protein Accession:
    P62750
    Secondary Accessions:
    • B2R5B2
    • P29316
    • P39024
    • Q92774

    Protein attributes for RPL23A Gene

    Size:
    156 amino acids
    Molecular mass:
    17695 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL23A Gene

neXtProt entry for RPL23A Gene

Post-translational modifications for RPL23A Gene

Other Protein References for RPL23A Gene

No data available for DME Specific Peptides for RPL23A Gene

Domains & Families for RPL23A Gene

Gene Families for RPL23A Gene

Suggested Antigen Peptide Sequences for RPL23A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62750

UniProtKB/Swiss-Prot:

RL23A_HUMAN :
  • Belongs to the universal ribosomal protein uL23 family.
Family:
  • Belongs to the universal ribosomal protein uL23 family.
genes like me logo Genes that share domains with RPL23A: view

Function for RPL23A Gene

Molecular function for RPL23A Gene

GENATLAS Biochemistry:
60S ribosomal protein L23A
UniProtKB/Swiss-Prot Function:
This protein binds to a specific region on the 26S rRNA.

Gene Ontology (GO) - Molecular Function for RPL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding IDA,IEA 22658674
GO:0003735 structural constituent of ribosome NAS,IEA 9417910
GO:0005515 protein binding IPI 9687515
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with RPL23A: view
genes like me logo Genes that share phenotypes with RPL23A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL23A Gene

Localization for RPL23A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL23A gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for RPL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 9687515
GO:0005730 nucleolus IDA 16791210
GO:0005737 cytoplasm IDA 16791210
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPL23A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL23A Gene

Pathways & Interactions for RPL23A Gene

genes like me logo Genes that share pathways with RPL23A: view

Pathways by source for RPL23A Gene

1 KEGG pathway for RPL23A Gene
1 GeneGo (Thomson Reuters) pathway for RPL23A Gene

Gene Ontology (GO) - Biological Process for RPL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,IEA 9417910
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL23A: view

No data available for SIGNOR curated interactions for RPL23A Gene

Drugs & Compounds for RPL23A Gene

(3) Drugs for RPL23A Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL23A: view

Transcripts for RPL23A Gene

Unigene Clusters for RPL23A Gene

Ribosomal protein L23a:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL23A Gene

No ASD Table

Relevant External Links for RPL23A Gene

GeneLoc Exon Structure for
RPL23A
ECgene alternative splicing isoforms for
RPL23A

Expression for RPL23A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL23A Gene

Protein differential expression in normal tissues from HIPED for RPL23A Gene

This gene is overexpressed in Tlymphocyte (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL23A Gene



Protein tissue co-expression partners for RPL23A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL23A Gene:

RPL23A

SOURCE GeneReport for Unigene cluster for RPL23A Gene:

Hs.419463

Evidence on tissue expression from TISSUES for RPL23A Gene

  • Liver(4.9)
  • Skin(4.9)
  • Eye(4.8)
  • Lung(4.8)
  • Pancreas(4.5)
  • Nervous system(4.5)
  • Adrenal gland(4.4)
  • Intestine(4.4)
  • Muscle(4.3)
  • Blood(4.1)
  • Kidney(4)
  • Heart(3.2)
  • Stomach(3.2)
  • Thyroid gland(3.2)
  • Bone(2.9)
  • Lymph node(2.2)
  • Bone marrow(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with RPL23A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL23A Gene

Orthologs for RPL23A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL23A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL23A 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 100 (a)
OneToMany
-- 35
  • 100 (a)
OneToMany
-- 35
  • 99 (a)
OneToMany
-- 35
  • 99 (a)
OneToMany
LOC610129 34
  • 89.96 (n)
-- 35
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm10132 35
  • 100 (a)
OneToMany
Gm10335 35
  • 99 (a)
OneToMany
Rpl23a-ps3 35
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RPL23A 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 95 (a)
OneToMany
-- 35
  • 94 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPL23A 34 35
  • 91.03 (n)
rat
(Rattus norvegicus)
Mammalia RGD1564606 34
  • 89.1 (n)
chicken
(Gallus gallus)
Aves RPL23A 35
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL23A 35
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25182 34
zebrafish
(Danio rerio)
Actinopterygii rpl23a 35
  • 94 (a)
OneToOne
wufa93f05 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.728 34
fruit fly
(Drosophila melanogaster)
Insecta RpL23a 36
  • 71 (a)
RpL23A 35
  • 37 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006037 34
  • 66.95 (n)
worm
(Caenorhabditis elegans)
Secernentea rpl-25.1 36 35
  • 65 (a)
rpl-25.2 36 35
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL25 35 37
  • 64 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2702 34
corn
(Zea mays)
Liliopsida Zm.6079 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1725 35
  • 77 (a)
OneToOne
Species where no ortholog for RPL23A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL23A Gene

ENSEMBL:
Gene Tree for RPL23A (if available)
TreeFam:
Gene Tree for RPL23A (if available)

Paralogs for RPL23A Gene

(2) SIMAP similar genes for RPL23A Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for RPL23A Gene

genes like me logo Genes that share paralogs with RPL23A: view

No data available for Paralogs for RPL23A Gene

Variants for RPL23A Gene

Sequence variations from dbSNP and Humsavar for RPL23A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000340537 -- 28,723,984(+) ACACA(C/G)ACACT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000673498 -- 28,722,930(+) AGCAG(C/G)CTGGA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001178674 -- 28,721,774(+) TCTAC(-/TCTT)TCTTA intron-variant, upstream-variant-2KB
rs1001666210 -- 28,724,805(+) TGAGG(A/G)AGATG downstream-variant-500B, reference, missense
rs1001859064 -- 28,721,564(+) GTATT(A/T)GGCAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL23A Gene

Variant ID Type Subtype PubMed ID
nsv1064087 CNV gain 25217958
nsv960457 CNV duplication 23825009

Variation tolerance for RPL23A Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL23A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL23A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL23A Gene

Disorders for RPL23A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL23A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia
  • diamond-blackfan anemia 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RPL23A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL23A
genes like me logo Genes that share disorders with RPL23A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL23A Gene

Publications for RPL23A Gene

  1. Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene. (PMID: 9417910) Fan W. … Lennon G. (Genomics 1997) 2 3 4 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PMID: 9687515) Jaekel S. … Goerlich D. (EMBO J. 1998) 3 22 64
  5. Suppression of human ribosomal protein L23A expression during cell growth inhibition by interferon-beta. (PMID: 9053844) Jiang H. … Fisher P.B. (Oncogene 1997) 3 22 64

Products for RPL23A Gene

Sources for RPL23A Gene

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