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Aliases for RPL23A Gene

Aliases for RPL23A Gene

  • Ribosomal Protein L23a 2 3
  • Melanoma Differentiation-Associated Gene 20 3
  • 60S Ribosomal Protein L23a 3
  • MDA20 3
  • L23A 3

External Ids for RPL23A Gene

Previous GeneCards Identifiers for RPL23A Gene

  • GC17P026892
  • GC17P028946
  • GC17P027192
  • GC17P024072
  • GC17P027046

Summaries for RPL23A Gene

Entrez Gene Summary for RPL23A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL23A Gene

RPL23A (Ribosomal Protein L23a) is a Protein Coding gene. Diseases associated with RPL23A include pure red-cell aplasia. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include nucleotide binding and rRNA binding.

UniProtKB/Swiss-Prot for RPL23A Gene

  • This protein binds to a specific region on the 26S rRNA.

Gene Wiki entry for RPL23A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL23A Gene

Genomics for RPL23A Gene

Regulatory Elements for RPL23A Gene

Genomic Location for RPL23A Gene

Start:
28,719,393 bp from pter
End:
28,724,359 bp from pter
Size:
4,967 bases
Orientation:
Plus strand

Genomic View for RPL23A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL23A Gene

Proteins for RPL23A Gene

  • Protein details for RPL23A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62750-RL23A_HUMAN
    Recommended name:
    60S ribosomal protein L23a
    Protein Accession:
    P62750
    Secondary Accessions:
    • B2R5B2
    • P29316
    • P39024
    • Q92774

    Protein attributes for RPL23A Gene

    Size:
    156 amino acids
    Molecular mass:
    17695 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL23A Gene

neXtProt entry for RPL23A Gene

Proteomics data for RPL23A Gene at MOPED

Post-translational modifications for RPL23A Gene

Other Protein References for RPL23A Gene

No data available for DME Specific Peptides for RPL23A Gene

Domains for RPL23A Gene

Gene Families for RPL23A Gene

HGNC:
  • RPL :L ribosomal proteins

Suggested Antigen Peptide Sequences for RPL23A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62750

UniProtKB/Swiss-Prot:

RL23A_HUMAN :
  • P62750
Family:
  • Belongs to the ribosomal protein L23P family.
genes like me logo Genes that share domains with RPL23A: view

Function for RPL23A Gene

Molecular function for RPL23A Gene

GENATLAS Biochemistry: 60S ribosomal protein L23A
UniProtKB/Swiss-Prot Function: This protein binds to a specific region on the 26S rRNA.

Gene Ontology (GO) - Molecular Function for RPL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 24725412
GO:0019843 rRNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL23A: view
genes like me logo Genes that share phenotypes with RPL23A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL23A Gene

Localization for RPL23A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL23A Gene COMPARTMENTS Subcellular localization image for RPL23A gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for RPL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 9687515
GO:0005730 nucleolus IDA 16791210
GO:0005737 cytoplasm IDA 16791210
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPL23A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL23A Gene

Pathways for RPL23A Gene

genes like me logo Genes that share pathways with RPL23A: view

Pathways by source for RPL23A Gene

1 KEGG pathway for RPL23A Gene
1 GeneGo (Thomson Reuters) pathway for RPL23A Gene

Gene Ontology (GO) - Biological Process for RPL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL23A: view

Compounds for RPL23A Gene

(3) Drugbank Compounds for RPL23A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
target
ANISOMYCIN
target
PUROMYCIN
target
genes like me logo Genes that share compounds with RPL23A: view

Transcripts for RPL23A Gene

Unigene Clusters for RPL23A Gene

Ribosomal protein L23a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL23A Gene

No ASD Table

Relevant External Links for RPL23A Gene

GeneLoc Exon Structure for
RPL23A
ECgene alternative splicing isoforms for
RPL23A

Expression for RPL23A Gene

mRNA expression in normal human tissues for RPL23A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL23A Gene

SOURCE GeneReport for Unigene cluster for RPL23A Gene Hs.419463

genes like me logo Genes that share expressions with RPL23A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL23A Gene

Orthologs for RPL23A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL23A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL23A 35
  • 100 (n)
  • 100 (a)
RPL23A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPL23A 35
  • 91.03 (n)
  • 100 (a)
RPL23A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 99 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
LOC610129 35
  • 89.96 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Gm10132 36
  • 100 (a)
OneToMany
Gm10335 36
  • 99 (a)
OneToMany
Rpl23a 16
Rpl23a-ps3 36
  • 99 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RPL23A 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1564606 35
  • 89.1 (n)
  • 98.72 (a)
chicken
(Gallus gallus)
Aves RPL23A 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL23A 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25182 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.728 35
zebrafish
(Danio rerio)
Actinopterygii rpl23a 36
  • 94 (a)
OneToOne
wufa93f05 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006037 35
  • 66.95 (n)
  • 69.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL23A 36
  • 37 (a)
OneToOne
RpL23a 37
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-25.1 36
  • 63 (a)
OneToMany
rpl-25.2 36
  • 65 (a)
OneToMany
rpl-25.2 37
  • 65 (a)
rpl-25.1 37
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL25 36
  • 64 (a)
OneToOne
RPL25 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2702 35
corn
(Zea mays)
Liliopsida Zm.6079 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1725 36
  • 77 (a)
OneToOne
Species with no ortholog for RPL23A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL23A Gene

ENSEMBL:
Gene Tree for RPL23A (if available)
TreeFam:
Gene Tree for RPL23A (if available)

Paralogs for RPL23A Gene

Selected SIMAP similar genes for RPL23A Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for RPL23A Gene

genes like me logo Genes that share paralogs with RPL23A: view

No data available for Paralogs for RPL23A Gene

Variants for RPL23A Gene

Sequence variations from dbSNP and Humsavar for RPL23A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_069221 -

Structural Variations from Database of Genomic Variants (DGV) for RPL23A Gene

Variant ID Type Subtype PubMed ID
nsv908028 CNV Loss 21882294

Relevant External Links for RPL23A Gene

HapMap Linkage Disequilibrium report
RPL23A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL23A Gene

Disorders for RPL23A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RPL23A Gene including...

Search for RPL23A Gene in MalaCards »

(2) University of Copenhagen DISEASES for RPL23A Gene

(1) Novoseek inferred disease relationships for RPL23A Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1
genes like me logo Genes that share disorders with RPL23A: view

No data available for UniProtKB/Swiss-Prot for RPL23A Gene

Publications for RPL23A Gene

  1. Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene. (PMID: 9417910) Fan W. … Lennon G. (Genomics 1997) 2 3 4
  2. Suppression of human ribosomal protein L23A expression during cell growth inhibition by interferon-beta. (PMID: 9053844) Jiang H. … Fisher P.B. (Oncogene 1997) 3 23
  3. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PMID: 9687515) Jaekel S. … Goerlich D. (EMBO J. 1998) 3 23
  4. Identification of seven new human MHC class I region genes around the HLA-F locus. (PMID: 8662070) Fan W. … Weissman S.M. (Immunogenetics 1996) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RPL23A Gene

Sources for RPL23A Gene

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