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Aliases for RPL23A Gene

Aliases for RPL23A Gene

  • Ribosomal Protein L23a 2 3 5
  • Melanoma Differentiation-Associated Gene 20 3
  • MDA20 3
  • L23a 3

External Ids for RPL23A Gene

Previous GeneCards Identifiers for RPL23A Gene

  • GC17P026892
  • GC17P028946
  • GC17P027192
  • GC17P024072
  • GC17P027046

Summaries for RPL23A Gene

Entrez Gene Summary for RPL23A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL23A Gene

RPL23A (Ribosomal Protein L23a) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL23A Gene

  • This protein binds to a specific region on the 26S rRNA.

Gene Wiki entry for RPL23A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL23A Gene

Genomics for RPL23A Gene

Regulatory Elements for RPL23A Gene

Promoters for RPL23A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL23A on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL23A Gene

Chromosome:
17
Start:
28,719,393 bp from pter
End:
28,724,359 bp from pter
Size:
4,967 bases
Orientation:
Plus strand

Genomic View for RPL23A Gene

Genes around RPL23A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL23A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL23A Gene

Proteins for RPL23A Gene

  • Protein details for RPL23A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62750-RL23A_HUMAN
    Recommended name:
    60S ribosomal protein L23a
    Protein Accession:
    P62750
    Secondary Accessions:
    • B2R5B2
    • P29316
    • P39024
    • Q92774

    Protein attributes for RPL23A Gene

    Size:
    156 amino acids
    Molecular mass:
    17695 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL23A Gene

neXtProt entry for RPL23A Gene

Proteomics data for RPL23A Gene at MOPED

Post-translational modifications for RPL23A Gene

Other Protein References for RPL23A Gene

Antibody Products

No data available for DME Specific Peptides for RPL23A Gene

Domains & Families for RPL23A Gene

Gene Families for RPL23A Gene

Suggested Antigen Peptide Sequences for RPL23A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62750

UniProtKB/Swiss-Prot:

RL23A_HUMAN :
  • Belongs to the ribosomal protein L23P family.
Family:
  • Belongs to the ribosomal protein L23P family.
genes like me logo Genes that share domains with RPL23A: view

Function for RPL23A Gene

Molecular function for RPL23A Gene

GENATLAS Biochemistry:
60S ribosomal protein L23A
UniProtKB/Swiss-Prot Function:
This protein binds to a specific region on the 26S rRNA.

Gene Ontology (GO) - Molecular Function for RPL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IEA,IPI 9687515
genes like me logo Genes that share ontologies with RPL23A: view
genes like me logo Genes that share phenotypes with RPL23A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL23A Gene

Localization for RPL23A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL23A Gene COMPARTMENTS Subcellular localization image for RPL23A gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
chloroplast 1

Gene Ontology (GO) - Cellular Components for RPL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 16791210
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL23A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL23A Gene

Pathways & Interactions for RPL23A Gene

genes like me logo Genes that share pathways with RPL23A: view

Pathways by source for RPL23A Gene

1 BioSystems pathway for RPL23A Gene
1 KEGG pathway for RPL23A Gene
1 GeneGo (Thomson Reuters) pathway for RPL23A Gene

Gene Ontology (GO) - Biological Process for RPL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL23A: view

No data available for SIGNOR curated interactions for RPL23A Gene

Drugs & Compounds for RPL23A Gene

(3) Drugs for RPL23A Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
anisomycin Experimental Pharma Target JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL23A: view

Transcripts for RPL23A Gene

Unigene Clusters for RPL23A Gene

Ribosomal protein L23a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL23A Gene

No ASD Table

Relevant External Links for RPL23A Gene

GeneLoc Exon Structure for
RPL23A
ECgene alternative splicing isoforms for
RPL23A

Expression for RPL23A Gene

mRNA expression in normal human tissues for RPL23A Gene

Protein differential expression in normal tissues from HIPED for RPL23A Gene

This gene is overexpressed in Tlymphocyte (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL23A Gene



SOURCE GeneReport for Unigene cluster for RPL23A Gene Hs.419463

genes like me logo Genes that share expression patterns with RPL23A: view

Protein tissue co-expression partners for RPL23A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL23A Gene

Orthologs for RPL23A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL23A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPL23A 35
  • 91.03 (n)
  • 100 (a)
RPL23A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC610129 35
  • 89.96 (n)
  • 100 (a)
-- 36
  • 99 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RPL23A 35
  • 100 (n)
  • 100 (a)
RPL23A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1564606 35
  • 89.1 (n)
  • 98.72 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm10132 36
  • 100 (a)
OneToMany
Gm10335 36
  • 99 (a)
OneToMany
Rpl23a-ps3 36
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RPL23A 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL23A 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL23A 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25182 35
zebrafish
(Danio rerio)
Actinopterygii wufa93f05 35
rpl23a 36
  • 94 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.728 35
fruit fly
(Drosophila melanogaster)
Insecta RpL23a 37
  • 71 (a)
RpL23A 36
  • 37 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006037 35
  • 66.95 (n)
  • 69.75 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-25.1 37
  • 65 (a)
rpl-25.2 37
  • 65 (a)
rpl-25.1 36
  • 63 (a)
OneToMany
rpl-25.2 36
  • 65 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL25 36
  • 64 (a)
OneToOne
RPL25 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2702 35
corn
(Zea mays)
Liliopsida Zm.6079 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1725 36
  • 77 (a)
OneToOne
Species with no ortholog for RPL23A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL23A Gene

ENSEMBL:
Gene Tree for RPL23A (if available)
TreeFam:
Gene Tree for RPL23A (if available)

Paralogs for RPL23A Gene

(2) SIMAP similar genes for RPL23A Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for RPL23A Gene

genes like me logo Genes that share paralogs with RPL23A: view

No data available for Paralogs for RPL23A Gene

Variants for RPL23A Gene

Sequence variations from dbSNP and Humsavar for RPL23A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_069221 -

Structural Variations from Database of Genomic Variants (DGV) for RPL23A Gene

Variant ID Type Subtype PubMed ID
nsv908028 CNV Loss 21882294

Variation tolerance for RPL23A Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL23A Gene

HapMap Linkage Disequilibrium report
RPL23A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL23A Gene

Disorders for RPL23A Gene

Relevant External Links for RPL23A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL23A

No disorders were found for RPL23A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL23A Gene

Publications for RPL23A Gene

  1. Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene. (PMID: 9417910) Fan W. … Lennon G. (Genomics 1997) 2 3 4 67
  2. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PMID: 9687515) Jaekel S. … Goerlich D. (EMBO J. 1998) 3 23
  3. Suppression of human ribosomal protein L23A expression during cell growth inhibition by interferon-beta. (PMID: 9053844) Jiang H. … Fisher P.B. (Oncogene 1997) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for RPL23A Gene

Sources for RPL23A Gene

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