Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RPL23A Gene

protein-coding   GIFtS: 64
GCID: GC17P027046

Ribosomal Protein L23a

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ribosomal Protein L23a1 2
60S Ribosomal Protein L23a2
L23A2
MDA202
Melanoma Differentiation-Associated Gene 202

External Ids:    HGNC: 103171   Entrez Gene: 61472   Ensembl: ENSG000001982427   OMIM: 6023265   UniProtKB: P627503   

Export aliases for RPL23A gene to outside databases

Previous GC identifers: GC17P026892 GC17P028946 GC17P027192 GC17P024072


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RPL23A Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family
of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in
mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the
26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are
located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal
proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (provided by
RefSeq, Jul 2008)

GeneCards Summary for RPL23A Gene:
RPL23A (ribosomal protein L23a) is a protein-coding gene. Diseases associated with RPL23A include amebiasis, and pure red-cell aplasia. GO annotations related to this gene include rRNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: RL23A_HUMAN, P62750
Function: This protein binds to a specific region on the 26S rRNA (By similarity)

Gene Wiki entry for RPL23A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL23A gene promoter:
         SRF   HFH-3   ATF-2   SRF (504 AA)   Tal-1beta   E47   CRE-BP1   FOXI1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL23A promoter sequence
   Search Chromatin IP Primers for RPL23A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL23A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

RPL23A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL23A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P027046:  view genomic region     (about GC identifiers)

Start:
27,046,411 bp from pter      End:
27,051,377 bp from pter
Size:
4,967 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RL23A_HUMAN, P62750 (See protein sequence)
Recommended Name: 60S ribosomal protein L23a  
Size: 156 amino acids; 17695 Da
1 PDB 3D structure from and Proteopedia for RPL23A:
3J3B (3D)    
Secondary accessions: B2R5B2 P29316 P39024 Q92774

Explore the universe of human proteins at neXtProt for RPL23A: NX_P62750

Explore proteomics data for RPL23A at MOPED

Post-translational modifications: 

  • N-terminus is methylated by METTL11A/NTM1 (By similarity)1
  • Citrullinated by PADI4 (By similarity)1
  • Ubiquitination2 at Lys70, Lys78, Lys115, Lys123
  • Modification sites at PhosphoSitePlus

  • See RPL23A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000975.2  
    ENSEMBL proteins: 
     ENSP00000389103   ENSP00000468172   ENSP00000378396   ENSP00000468402   ENSP00000347969  
     ENSP00000466425   ENSP00000465342  
    Reactome Protein details: P62750

    RPL23A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RPL23A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RPL23A
    GenScript Custom Purified and Recombinant Proteins Services for RPL23A
    Novus Biologicals RPL23A Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RPL23A
    Cloud-Clone Corp. Proteins for RPL23A

    RPL23A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RPL23A
    Novus Biologicals RPL23A Antibodies
    Abcam antibodies for RPL23A
    Cloud-Clone Corp. Antibodies for RPL23A
    ThermoFisher Antibodies for RPL23A
    LSBio Antibodies in human, mouse, rat for RPL23A

    RPL23A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RPL23A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RPL23A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RPL23A
    Cloud-Clone Corp. CLIAs for RPL23A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RPL: L ribosomal proteins

    Selected InterPro protein domains (see all 6):
     IPR012678 Ribosomal_L23/L15e_core_dom
     IPR019985 Ribosomal_L23
     IPR001014 Ribosomal_L23/L25_CS
     IPR005633 Ribosomal_L23/L25_N
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry P62750

    ProtoNet protein and cluster: P62750

    2 Blocks protein domains:
    IPB001014 Ribosomal L23 protein
    IPB005633 Ribosomal protein L23


    UniProtKB/Swiss-Prot: RL23A_HUMAN, P62750
    Similarity: Belongs to the ribosomal protein L23P family


    RPL23A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RL23A_HUMAN, P62750
    Function: This protein binds to a specific region on the 26S rRNA (By similarity)

         Genatlas biochemistry entry for RPL23A:
    60S ribosomal protein L23A

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0005515protein binding IPI9687515
    GO:0019843rRNA binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    RPL23A for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for RPL23A:
     Decreased cell number, increas  Decreased viability  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 
     S arrest 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL23A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPL23A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPL23A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPL23A

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPL23A:
    hsa-mir-877-5p (MIRT037257), hsa-mir-193b-3p (MIRT041229), hsa-mir-671-5p (MIRT039258), hsa-mir-769-3p (MIRT039135), hsa-mir-423-5p (MIRT038169)

    Block miRNA regulation of human, mouse, rat RPL23A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPL23A (see all 12):
    hsa-miR-203 hsa-miR-676 hsa-miR-3166 hsa-miR-1324 hsa-miR-3126-5p hsa-miR-378b hsa-miR-146a* hsa-miR-422a
    SwitchGear 3'UTR luciferase reporter plasmidRPL23A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RPL23A
    Predesigned siRNA for gene silencing in human, mouse, rat RPL23A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPL23A

    Clone
    Products:
         
    OriGene clones in human, mouse for RPL23A (see all 7)
    OriGene ORF clones in mouse, rat for RPL23A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPL23A (NM_000984)
    Sino Biological Human cDNA Clone for RPL23A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL23A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL23A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RPL23A
    Browse ESI BIO Cell Lines and PureStem Progenitors for RPL23A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL23A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA9687515
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit NAS9417910

    RPL23A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RPL23A About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL23A
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL23A
        Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPL23A (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL23A):
        Ribosome


    RPL23A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL23A
    Interactions:

        Search GeneGlobe Interaction Network for RPL23A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL23A (P627502, 3 ENSP000003891034) via UniProtKB, MINT, STRING, and/or I2D (see all 973)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL4P365782, 3, ENSP000003114304MINT-7945693 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000311430
    RPL11P629132, 3, ENSP000003636764MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000363676
    RPL19P840982, 3, ENSP000002254304MINT-7945693 MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000225430
    RPL35P427662, 3, ENSP000002594694MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000259469
    RPL8P629172, 3, ENSP000002625844MINT-7945693 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000262584
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPL23A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL23A (RL23A)

    3 DrugBank Compounds for RPL23A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ANISOMYCIN-- --target--10592235
    Alpha-Hydroxy-Beta-Phenyl-Propionic Acid-- --target--10592235
    PUROMYCIN-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RPL23A gene: 
    NM_000984.5  

    Unigene Cluster for RPL23A:

    Ribosomal protein L23a
    Hs.419463  [show with all ESTs]
    Unigene Representative Sequence: BF972099
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422514(uc002hci.3 uc021ttu.1) ENST00000582736 ENST00000496182
    ENST00000394938 ENST00000394935 ENST00000355731 ENST00000472628 ENST00000578181
    ENST00000580755
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RPL23A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPL23A (see all 12):
    hsa-miR-203 hsa-miR-676 hsa-miR-3166 hsa-miR-1324 hsa-miR-3126-5p hsa-miR-378b hsa-miR-146a* hsa-miR-422a
    SwitchGear 3'UTR luciferase reporter plasmidRPL23A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RPL23A
    Predesigned siRNA for gene silencing in human, mouse, rat RPL23A
    Clone
    Products:
         
    OriGene clones in human, mouse for RPL23A (see all 7)
    OriGene ORF clones in mouse, rat for RPL23A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPL23A (NM_000984)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL23A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL23A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RPL23A
    OriGene qSTAR qPCR primer pairs in human, mouse for RPL23A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPL23A
      QuantiTect SYBR Green Assays in human, mouse, rat RPL23A
      QuantiFast Probe-based Assays in human, mouse, rat RPL23A

    Additional mRNA sequence: 

    AK130965.1 AK312123.1 BC014459.1 BC058041.1 BC070191.1 L13799.1 U02032.1 U37230.1 
    U43701.1 

    Selected DOTS entries (see all 74):

    DT.99926704  DT.100742395  DT.91801750  DT.100055010  DT.92049415  DT.100742458  DT.100742498  DT.100742454 
    DT.91936191  DT.97869792  DT.100742433  DT.100040220  DT.120945082  DT.98083132  DT.97869757  DT.101958706 
    DT.97869782  DT.120898225  DT.101958731  DT.91779539  DT.98083127  DT.100742472  DT.100742410  DT.102843807 

    Selected AceView cDNA sequences (see all 3749):

    BQ651037 BM712560 CD513925 BQ683263 BM756621 AJ706329 AA626694 BQ649352 
    CA427222 BQ953613 AJ709430 BE252705 BM827207 BQ686348 BU162824 BM838413 
    BF972514 BU553657 BM714226 BQ071368 BG424400 AI620215 BQ049130 BQ055774 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RPL23A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAGATAG
    RPL23A Expression
    About this image

    RPL23A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL23A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.419463
        Custom PCR Arrays for RPL23A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RPL23A
    OriGene qSTAR qPCR primer pairs in human, mouse for RPL23A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPL23A
    QuantiTect SYBR Green Assays in human, mouse, rat RPL23A
    QuantiFast Probe-based Assays in human, mouse, rat RPL23A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL23A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL23A gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl23a5 ribosomal protein L23A   --   11 (46.74 cM) 78180932 
    chicken
    (Gallus gallus)
    Aves RPL23A6
    ribosomal protein L23a
    98(a)
    1 ↔ 1
    19(5800727-5803129)
    lizard
    (Anolis carolinensis)
    Reptilia RPL23A6
    ribosomal protein L23a
    95(a)
    1 ↔ 1
    AAWZ02039090(1432-9505)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.251822 Xenopus laevis transcribed sequence with strong similarity more 82.56(n)    CB197461.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa93f052 Transcribed sequence with strong similarity to protein more 81.95(n)    57074226 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL23a3 protein biosynthesis structural
    constituent of more
    71(a)   62A10   --
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-25.23 60S ribosomal protein 65(a)
    (best of 2)
      I(8337015-8337890)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL25(YOL127W)4 Primary rRNA-binding ribosomal protein component of more   --   15(80348-81190) 853993  NP_014514.1 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.27022 Vitis vinifera transcribed sequence with moderate similarity more 78.22(n)    CA816335.1 
    corn
    (Zea mays)
    Liliopsida Zm.60792 Zea mays ribosomal protein L25 mRNA, partial cds 79.1(n)    AY104035.1 


    ENSEMBL Gene Tree for RPL23A (if available)
    TreeFam Gene Tree for RPL23A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RPL23A gene
    2 SIMAP similar genes for RPL23A using alignment to 6 protein entries:     RL23A_HUMAN (see all proteins):
    DKFZp547I014    RPL23AL

    RPL23A for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPL23A (see all 104)
    PGOHUM00000262834 PGOHUM00000238615 PGOHUM00000238911 PGOHUM00000262837 PGOHUM00000242490


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    1 SNPs for RPL23A    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0692214
    ----see VAR_0692212 I T mis40--------

    HapMap Linkage Disequilibrium report for RPL23A (27046411 - 27051377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RPL23A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908028CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL23A
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL23A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602326    OMIM disorders: --

    11 diseases for RPL23A:    About MalaCards
    amebiasis    pure red-cell aplasia    diamond-blackfan anemia    treacher collins syndrome
    melanoma    vaccinia    influenza    multiple myeloma
    breast cancer    myeloma    malaria

    2 diseases from the University of Copenhagen DISEASES database for RPL23A:
    Diamond-Blackfan anemia     Pure red-cell aplasia

    RPL23A for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RPL23A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 14981896 (1)


    Export disorders for RPL23A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RPL23A gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with RPL23A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene. (PubMed id 9417910)1, 2, 3 Fan W.... Lennon G. (Genomics 1997)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Identification of seven new human MHC class I region genes around the HLA-F locus. (PubMed id 8662070)1, 2 Fan W.... Weissman S.M. (Immunogenetics 1996)
    5. Suppression of human ribosomal protein L23A expression during cell growth inhibition by interferon-beta. (PubMed id 9053844)1, 9 Jiang H....Fisher P.B. (Oncogene 1997)
    6. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PubMed id 9687515)1, 9 Jaekel S. and Goerlich D. (EMBO J. 1998)
    7. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    8. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    9. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)
    10. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6147 HGNC: 10317 AceView: RPL23A Ensembl:ENSG00000198242 euGenes: HUgn6147
    ECgene: RPL23A Kegg: 6147 H-InvDB: RPL23A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RPL23A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RPL23A gene:
    Search GeneIP for patents involving RPL23A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RPL23A  
     OriGene qPCR primer pairs and template standards for RPL23A   OriGene Protein Over-expression Lysate for RPL23A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RPL23A  
     OriGene qSTAR qPCR primer pairs in human, mouse for RPL23A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RPL23A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPL23A   OriGene Custom Protein Services for RPL23A  

     
     
     Block miRNA regulation of human, mouse, rat RPL23A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RPL23A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL23A Predesigned siRNA for gene silencing in human, mouse, rat RPL23A
     QuantiFast Probe-based Assays in human, mouse, rat RPL23A QuantiTect SYBR Green Assays in human, mouse, rat RPL23A
     Custom PCR Arrays for RPL23A Search Chromatin IP Primers for RPL23A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPL23A  Search GeneGlobe Interaction Network for RPL23A
     Regulatory tfbs in RPL23A promoter
     GenScript Custom Purified and Recombinant Proteins Services for RPL23A GenScript cDNA clones with any tag delivered in your preferred vector for RPL23A
     GenScript Custom Assay Services for RPL23A GenScript Custom overexpressing Cell Line Services for RPL23A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RPL23A (RL23A)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for RPL23A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RPL23A antibodies
     RPL23A proteins
     Antibodies for RPL23A
     See all of Abcam's Antibodies, Kits and Proteins for RPL23A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RPL23A
     Proteins for RPL23A
     Antibodies for RPL23A
     ELISAs for RPL23A
     CLIAs for RPL23A



     Browse ESI BIO Cell Lines and PureStem Progenitors for RPL23A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL23A
     SwitchGear 3'UTR luciferase reporter plasmids for RPL23A
     SwitchGear Promoter luciferase reporter plasmids for RPL23A
     ThermoFisher Antibodies for RPL23A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL23A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL23A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPL23A
     LSBio Antibodies in human, mouse, rat for RPL23A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RPL23A gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4