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Aliases for RPL23 Gene

Aliases for RPL23 Gene

  • Ribosomal Protein L23 2 3 5
  • Large Ribosomal Subunit Protein UL14 3 4
  • 60S Ribosomal Protein L17 3 4
  • 60S Ribosomal Protein L23 3
  • Ribosomal Protein L17 3
  • RpL17 3
  • L23 3

External Ids for RPL23 Gene

Previous GeneCards Identifiers for RPL23 Gene

  • GC17M036491
  • GC17M039004
  • GC17M036914
  • GC17M037381
  • GC17M034259
  • GC17M037005

Summaries for RPL23 Gene

Entrez Gene Summary for RPL23 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL23 Gene

RPL23 (Ribosomal Protein L23) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL23 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL23 Gene

Genomics for RPL23 Gene

Regulatory Elements for RPL23 Gene

Enhancers for RPL23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G038584 1.5 Ensembl ENCODE dbSUPER 31.7 +268.8 268830 1.7 ATF1 ZNF493 ARID4B GLI4 DMAP1 ZNF2 ZNF48 ZNF121 GLIS2 ZNF143 MED1 ENSG00000266469 RPL23 SNORA21 ENSG00000275532 CDK12 RPL19 ENSG00000274996 LOC105371761
GH17G038920 1.4 Ensembl ENCODE dbSUPER 15.6 -68.4 -68383 3.1 TBP ZFP64 PAF1 ZNF202 ZNF654 CEBPB ZNF426 REST ZNF623 ZNF518A MED1 ENSG00000266469 CDK12 SNORA21 ENSG00000275532 LOC100287808 RPL23 FBXO47 C17orf98 ENSG00000275665
GH17G038876 1.5 Ensembl ENCODE dbSUPER 13 -28.3 -28306 11.1 PKNOX1 ARNT ZFP64 SIN3A ARID4B FEZF1 YY1 SP5 MXD4 NFYC ENSG00000275532 LOC100287808 RPL23 RPS20P35 SNORA21 ENSG00000252699 C17orf98 CWC25 PSMB3 MED1
GH17G038823 1.2 ENCODE 15.7 +28.9 28906 3.0 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC ENSG00000266469 MED1 CDK12 SNORA21 LOC100287808 RPL19 RPL23 PIP4K2B ENSG00000275532 CWC25
GH17G038895 1.5 Ensembl ENCODE dbSUPER 12.5 -45.6 -45574 7.7 HDGF PKNOX1 ATF1 ARNT ZFP64 ARID4B SIN3A YY1 TCF12 ZNF121 LASP1 RPS20P35 RPL23 ENSG00000252699 SNORA21 MED1 CWC25 ENSG00000266469 LINC00672 ENSG00000266588
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL23 on UCSC Golden Path with GeneCards custom track

Promoters for RPL23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093824 500 2201 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for RPL23 Gene

38,847,865 bp from pter
38,853,843 bp from pter
5,979 bases
Minus strand

Genomic View for RPL23 Gene

Genes around RPL23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL23 Gene

Proteins for RPL23 Gene

  • Protein details for RPL23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L23
    Protein Accession:
    Secondary Accessions:
    • P23131
    • P24048
    • Q29246
    • Q3SWV7
    • Q6P5S1

    Protein attributes for RPL23 Gene

    140 amino acids
    Molecular mass:
    14865 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL23 Gene

neXtProt entry for RPL23 Gene

Post-translational modifications for RPL23 Gene

  • Ubiquitination at isoforms=35, Lys43, isoforms=66, isoforms=75, and Lys123
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL23 Gene

No data available for DME Specific Peptides for RPL23 Gene

Domains & Families for RPL23 Gene

Gene Families for RPL23 Gene

Protein Domains for RPL23 Gene

Suggested Antigen Peptide Sequences for RPL23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL14 family.
  • Belongs to the universal ribosomal protein uL14 family.
genes like me logo Genes that share domains with RPL23: view

Function for RPL23 Gene

Gene Ontology (GO) - Molecular Function for RPL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001223 transcription coactivator binding IPI 19160485
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 15314173
GO:0031625 ubiquitin protein ligase binding IPI 15314173
genes like me logo Genes that share ontologies with RPL23: view
genes like me logo Genes that share phenotypes with RPL23: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL23 Gene

Localization for RPL23 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL23 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
mitochondrion 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RPL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA 15314173
GO:0005730 nucleolus IDA,IEA 15314173
GO:0005737 cytoplasm IDA 15314173
GO:0005829 cytosol TAS --
GO:0005840 ribosome NAS,IEA 1874450
genes like me logo Genes that share ontologies with RPL23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL23 Gene

Pathways & Interactions for RPL23 Gene

genes like me logo Genes that share pathways with RPL23: view

Pathways by source for RPL23 Gene

1 KEGG pathway for RPL23 Gene
1 GeneGo (Thomson Reuters) pathway for RPL23 Gene

Gene Ontology (GO) - Biological Process for RPL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19160485
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,IEA 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL23: view

No data available for SIGNOR curated interactions for RPL23 Gene

Drugs & Compounds for RPL23 Gene

(4) Drugs for RPL23 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL23: view

Transcripts for RPL23 Gene

Unigene Clusters for RPL23 Gene

Ribosomal protein L23:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL23 Gene

No ASD Table

Relevant External Links for RPL23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL23 Gene

This gene is overexpressed in Bone (7.5) and Bone marrow mesenchymal stem cell (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL23 Gene

Protein tissue co-expression partners for RPL23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL23 Gene:


SOURCE GeneReport for Unigene cluster for RPL23 Gene:


Evidence on tissue expression from TISSUES for RPL23 Gene

  • Liver(4.8)
  • Nervous system(4.8)
  • Kidney(4.5)
  • Lung(4.5)
  • Eye(3.8)
  • Skin(3.7)
  • Intestine(3.6)
  • Heart(3.3)
  • Muscle(3.3)
  • Pancreas(2.9)
  • Blood(2.6)
  • Lymph node(2.6)
  • Bone marrow(2.5)
  • Spleen(2.5)
  • Adrenal gland(2.4)
  • Thyroid gland(2.4)
  • Gall bladder(2.3)
  • Stomach(2.3)
  • Bone(2.1)
genes like me logo Genes that share expression patterns with RPL23: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL23 Gene

Orthologs for RPL23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL23 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia RPL23 35
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia RPL23 35
  • 100 (a)
(Pan troglodytes)
Mammalia RPL23 34 35
  • 99.52 (n)
(Bos Taurus)
Mammalia RPL23 34 35
  • 93.57 (n)
(Rattus norvegicus)
Mammalia Rpl23 34
  • 92.86 (n)
(Canis familiaris)
Mammalia RPL23 34 35
  • 92.38 (n)
(Mus musculus)
Mammalia Rpl23 34 16 35
  • 91.19 (n)
(Gallus gallus)
Aves RPL23 34 35
  • 82.62 (n)
(Anolis carolinensis)
Reptilia RPL23 35
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl23 34
  • 81.19 (n)
Str.17122 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8093 34
(Danio rerio)
Actinopterygii rpl23 34 35
  • 84.05 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta RpL17A 36
  • 85 (a)
RpL23 34 35
  • 73.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010252 34
  • 73.57 (n)
(Caenorhabditis elegans)
Secernentea rpl-23 36 34 35
  • 72.62 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL23A 35 37
  • 79 (a)
RPL23B 34 35
  • 68.43 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL288W 34
  • 68.69 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06997g 34
  • 67.93 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G33370 34
  • 74.58 (n)
(Glycine max)
eudicotyledons Gma.5613 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6927 34
(Oryza sativa)
Liliopsida Os02g0814700 34
  • 72.66 (n)
(Zea mays)
Liliopsida Zm.12634 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7198 35
  • 86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02905 34
  • 69.32 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2301 34
  • 68.14 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5835 34
Species where no ortholog for RPL23 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL23 Gene

Gene Tree for RPL23 (if available)
Gene Tree for RPL23 (if available)

Paralogs for RPL23 Gene

No data available for Paralogs for RPL23 Gene

Variants for RPL23 Gene

Sequence variations from dbSNP and Humsavar for RPL23 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000125424 -- 38,854,507(+) CCTTG(C/G)TCCCT upstream-variant-2KB
rs1000500603 -- 38,854,655(+) CAGCA(G/T)GTTCT upstream-variant-2KB
rs1001082164 -- 38,855,351(+) GGAGG(C/T)GGAGG upstream-variant-2KB
rs1001492971 -- 38,855,641(+) GAGTT(C/G)AGGTG upstream-variant-2KB
rs1001954447 -- 38,851,486(+) GAAAC(C/T)CACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL23 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv833439 CNV loss 17160897

Variation tolerance for RPL23 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL23 Gene

Disorders for RPL23 Gene

Relevant External Links for RPL23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL23 Gene

Publications for RPL23 Gene

  1. cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17. (PMID: 1861993) Herault Y. … Brun G. (Nucleic Acids Res. 1991) 2 3 4 64
  2. A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. (PMID: 19160485) Wanzel M. … Eilers M. (Nat. Cell Biol. 2008) 3 22 64
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
  4. Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. (PMID: 15314173) Dai M.S. … Lu H. (Mol. Cell. Biol. 2004) 3 22 64
  5. Inhibition of HDM2 and activation of p53 by ribosomal protein L23. (PMID: 15314174) Jin A. … Zhang Y. (Mol. Cell. Biol. 2004) 3 22 64

Products for RPL23 Gene

Sources for RPL23 Gene

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