RPL23 Gene
protein-coding GIFtS: 56
GCID: GC17M037005
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ribosomal protein L23
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Aliases
for RPL23 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribosomal Protein L231 2 | | L231 2 | | RpL171 | | 60S Ribosomal Protein L172 3 | | 60S Ribosomal Protein L232 | | Ribosomal Protein L172 |
Export aliases for RPL23 gene to outside databasesPrevious GC identifers: GC17M036491 GC17M039004 GC17M036914 GC17M037381 GC17M034259 |
Summaries
for RPL23 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPL23:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This geneencodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family ofribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encodedprotein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its officialsymbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of thisgene dispersed through the genome. (provided by RefSeq, Jul 2008)
Gene Wiki entry for RPL23
|
Genomic Views
for RPL23 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPL23 gene promoter:
AhR RFX1 Evi-1 Arnt CREB AREB6 deltaCREB CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPL23
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL23 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12RPL23 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M037005: view genomic region
(about GC identifiers)
Start:
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37,004,118 bp from pter |
End:
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37,010,096 bp from pter |
Size:
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5,979 bases |
Orientation:
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minus strand |
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Proteins
for RPL23 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RL23_HUMAN, P62829 (See
protein sequence)Recommended Name: 60S ribosomal protein L23 Size: 140 amino acids; 14865 Da
Secondary accessions: P23131 P24048 Q29246 Q3SWV7 Q6P5S1Explore the universe of human proteins at neXtProt for RPL23: NX_P62829
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P62829
RPL23 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000969.1
ENSEMBL proteins: ENSP00000377865 ENSP00000377866 ENSP00000420311 ENSP00000463014 ENSP00000462773 ENSP00000463894 ENSP00000367336 Reactome Protein details: P62829
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
RPL23 for ontologies About GeneDecksing
RPL23 Antibody Products:
Assay Products for RPL23: |
Protein
Domains /
Families
for RPL23 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPL23 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P62829ProtoNet protein and cluster: P62829 UniProtKB/Swiss-Prot: RL23_HUMAN, P62829Similarity: Belongs to the ribosomal protein L14P family |
Function
for RPL23 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL23 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL23
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RPL23 (NM_000984) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPL23 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL23 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RPL23 for ontologies About GeneDecksing
7 GenomeRNAi human phenotypes for RPL23:
|
Pathways & Interactions
for RPL23 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Metabolism of mRNA | | | 3 | Disease | | | 4 | p53 pathway | | | 5 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  GeneGo (Thomson Reuters) Pathway for RPL23
2  BioSystems Pathways for RPL23
5/28 
Reactome Pathways for RPL23 (see all 28)
1 
Kegg Pathway (Kegg details for RPL23):
RPL23 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPL23
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/534 Interacting proteins for RPL23 (P628292, 3 ENSP000003778654) via UniProtKB, MINT, STRING, and/or I2D (see all 534)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
TAS | -- | | GO:0006412 | translation |
TAS | -- | | GO:0006413 | translational initiation |
TAS | -- | | GO:0006414 | translational elongation |
TAS | -- | | GO:0006415 | translational termination |
TAS | -- |
RPL23 for ontologies About GeneDecksing
|
Drugs & Compounds
for RPL23 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RPL23 for compounds About GeneDecksing
 Browse Tocris compounds for RPL23
3 DrugBank Compounds for RPL23 About this table
1 Novoseek chemical compound relationship for RPL23 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| serine |
20.3 |
1 |
17498616 (1) |
Search CenterWatch for drugs/clinical trials and news about RPL23 / RL23
|
Transcripts
for RPL23 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPL23 gene: NM_000978.3 Unigene Cluster for RPL23: Ribosomal protein L23 Hs.406300 [show with all ESTs]Unigene Representative Sequence: BI91218111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394332 ENST00000394333 ENST00000479035(uc002hqx.1) ENST00000245857
ENST00000584912(uc002hqy.1) ENST00000584583 ENST00000577407 ENST00000470646
ENST00000378096 ENST00000577760(uc002hqz.1) ENST00000584056
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL23 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL23
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RPL23 (NM_000984) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPL23 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL23 |
Additional cDNA sequence: AK024749.1 BC003518.1 BC010114.2 BC062716.1 BC104651.1 BC106061.1 X52839.1 X55954.1 24/82 DOTS entries (see all 82): DT.100060178 DT.92411435 DT.101956171 DT.101956165 DT.97761831 DT.305780 DT.100728060 DT.100728071 DT.100848722 DT.101956164 DT.120905906 DT.100728093 DT.100673704 DT.91771028 DT.95169960 DT.120905858 DT.95169812 DT.120905949 DT.120905849 DT.120905869 DT.100728090 DT.120905918 DT.95242891 DT.95088660 24/2012 AceView cDNA sequences (see all 2012): BE894290 BQ348226 AA131211 BU783331 F18870 AA628764 AA316430 W00983 AW304672 AA132617 AA335070 AA492147 CF130714 AA369017 BE781836 BG059304 BE293031 BQ643125 AA470547 AW610192 BQ881975 AW161024 AA679915 AA468951
GeneLoc Exon Structure
|
Expression
for RPL23 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPL23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTCTCCAGT
About this image
See RPL23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPL23
SOURCE GeneReport for Unigene cluster: Hs.406300
SABiosciences Custom PCR Arrays for RPL23
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPL23
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPL23 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL23 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL23 |
Orthologs
for RPL23 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for RPL23 gene from 11/46 species (see all 46) About this table
ENSEMBL Gene Tree for RPL23 (if available)
TreeFam Gene Tree for RPL23 (if available) |
Paralogs
for RPL23 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RPL23 gene
1 SIMAP similar gene for RPL23 using alignment to 6 protein entries: RL23_HUMAN (see all proteins):LOC222901
RPL23 for paralogs About GeneDecksing
5/12 Pseudogenes.org Pseudogenes for RPL23 (see all 12)
PGOHUM00000238719 PGOHUM00000244766 PGOHUM00000239060 PGOHUM00000241114 PGOHUM00000241117
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Genomic Variants
for RPL23 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RPL23 (37004118 - 37010096 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RPL23: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL23 |
|
Disorders
/ Diseases
for RPL23 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPL23 for disorders About GeneDecksing
OMIM gene information: 603662
OMIM disorders: --
8  diseases for RPL23: About MalaCardstreacher collins syndrome lung adenocarcinoma gastric cancer adenocarcinoma
pneumonia tuberculosis malaria mycobacterium tuberculosis
Export disorders for RPL23 gene to outside databases
|
Publications
for RPL23 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPL23 gene, integrated from 9 sources (see all 61):
(articles sorted by number of sources associating them with RPL23) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17. (PubMed id 1861993)1, 2, 3 Herault Y.... Brun G. (1991)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (2002)
- Isolation and analysis of a human cDNA highly homologous to the yeast gene encoding L17A ribosomal protein. (PubMed id 1874450)1, 2 Berchtold M.W. and Berger M.C. (1991)
- Inhibition of HDM2 and activation of p53 by ribosomal protein L23. (PubMed id 15314174)1, 9 Jin A....Zhang Y. (2004)
- Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. (PubMed id 15314173)1, 9 Dai M.S....Lu H. (2004)
- A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. (PubMed id 19160485)1, 9 Wanzel M....Eilers M. (2008)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Over-expression of RPL23 in myelodysplastic syndromes is associated with apoptosis resistance of CD34+ cells and predicts poor prognos is and distinct response to CHG chemotherapy or decitabine. (PubMed id 22580751)1 Wu L....Zhang Y. (2012)
|
External Searches for RPL23 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RPL23 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPL23 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPL23 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RPL23 gene:
Search GeneIP for patents involving RPL23
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPL23 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL23 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPL23 | | | OriGene Protein Over-expression Lysate for RPL23 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RPL23 | | OriGene 3'-UTR Clone for RPL23 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL23 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL23 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RPL23 | | OriGene Custom Protein Services for RPL23 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPL23 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL23 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL23 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL23 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL23 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL23 |
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 |  |  |  | |
| | | | Search Tocris compounds for RPL23 |
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 | | | RPL23 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for RPL23 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL23 |
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