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RPL23 Gene

protein-coding   GIFtS: 61
GCID: GC17M037005

Ribosomal Protein L23

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein L231 2
60S Ribosomal Protein L172 3
60S Ribosomal Protein L232
L232
Ribosomal Protein L172
rpL172

External Ids:    HGNC: 103161   Entrez Gene: 93492   Ensembl: ENSG000001256917   OMIM: 6036625   UniProtKB: P628293   

Export aliases for RPL23 gene to outside databases

Previous GC identifers: GC17M036491 GC17M039004 GC17M036914 GC17M037381 GC17M034259


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL23 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family
of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the
encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its
official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed
pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPL23 Gene:
RPL23 (ribosomal protein L23) is a protein-coding gene. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPL23 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL23 gene promoter:
         AhR   RFX1   Evi-1   Arnt   CREB   AREB6   deltaCREB   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RPL23 promoter sequence
   Search Chromatin IP Primers for RPL23

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

RPL23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL23 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M037005:  view genomic region     (about GC identifiers)

Start:
37,004,118 bp from pter      End:
37,010,096 bp from pter
Size:
5,979 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RL23_HUMAN, P62829 (See protein sequence)
Recommended Name: 60S ribosomal protein L23  
Size: 140 amino acids; 14865 Da
1 PDB 3D structure from and Proteopedia for RPL23:
3J3B (3D)    
Secondary accessions: P23131 P24048 Q29246 Q3SWV7 Q6P5S1

Explore the universe of human proteins at neXtProt for RPL23: NX_P62829

Explore proteomics data for RPL23 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys35, Lys43, Lys66, Lys75, Lys123
  • Modification sites at PhosphoSitePlus

  • See RPL23 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000969.1  
    ENSEMBL proteins: 
     ENSP00000377865   ENSP00000377866   ENSP00000420311   ENSP00000463014   ENSP00000462773  
     ENSP00000463894   ENSP00000367336  
    Reactome Protein details: P62829

    RPL23 Human Recombinant Protein Products:

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    Novus Biologicals RPL23 Proteins
    Novus Biologicals RPL23 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPL23

     
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    antibodies-online proteins for RPL23 (15 products) 

     
    antibodies-online peptides for RPL23

    RPL23 Antibody Products:

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    antibodies-online antibodies for RPL23 (23 products) 

    RPL23 Assay Products:

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    Cloud-Clone Corp. ELISAs for RPL23
    Cloud-Clone Corp. CLIAs for RPL23
    Search eBioscience for ELISAs for RPL23 
    antibodies-online kits for RPL23 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    3 InterPro protein domains:
     IPR023571 Ribosomal_L14_dom
     IPR000218 Ribosomal_L14b/L23e
     IPR019972 Ribosomal_L14_CS

    Graphical View of Domain Structure for InterPro Entry P62829

    ProtoNet protein and cluster: P62829

    UniProtKB/Swiss-Prot: RL23_HUMAN, P62829
    Similarity: Belongs to the ribosomal protein L14P family


    Find genes that share domains with RPL23           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0005515protein binding IPI17110929
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RPL23           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for RPL23:
     Decreased homologous recombina  Decreased viability of wild-ty  Increased S DNA content  Nuclear 40S maturation defects 
     Nuclear 60S biogenesis defects  Nuclear pre-40S maturation def  S arrest 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RPL23

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPL23:
    hsa-mir-124-3p (MIRT022730), hsa-mir-615-3p (MIRT039746), hsa-mir-3200-3p (MIRT052822), hsa-mir-503-5p (MIRT041095), hsa-mir-183-5p (MIRT047046)

    Block miRNA regulation of human, mouse, rat RPL23 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RPL23:
    hsa-miR-520d-5p hsa-miR-524-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RPL23

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    GenScript: all cDNA clones in your preferred vector: RPL23 (NM_000984)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL23

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL23


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion2
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome NAS1874450
    GO:0022625cytosolic large ribosomal subunit IDA12962325

    Find genes that share ontologies with RPL23           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPL23 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5p53 pathway
    p53 pathway


    Find genes that share SuperPaths with RPL23           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL23
        CFTR translational fidelity (class I mutations)

    2 BioSystems Pathways for RPL23
        Cytoplasmic Ribosomal Proteins
    p53 pathway

    Selected Reactome Pathways for RPL23 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL23):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL23
    Interactions:

        GeneGlobe Interaction Network for RPL23

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL23 (P628291, 2, 3 ENSP000003778654) via UniProtKB, MINT, STRING, and/or I2D (see all 611)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 2, 3, ENSP000004172814EBI-353303,EBI-389668 MINT-3391086 MINT-3391101 I2D: score=4 STRING: ENSP00000417281
    RPS3P233962, 3, ENSP000002785724MINT-6542674 MINT-6489539 MINT-6488590 MINT-6488488 MINT-6488791 I2D: score=3 STRING: ENSP00000278572
    EEF1A1P681042, 3MINT-6542674 MINT-6489217 MINT-6489539 MINT-6488590 MINT-6488488 MINT-6488791 I2D: score=1 
    RPL26P612542, 3, ENSP000002938424MINT-6542674 MINT-6489539 MINT-6488590 MINT-6488791 I2D: score=4 STRING: ENSP00000293842
    RPL11P629132, 3, ENSP000003636764MINT-6542674 MINT-6489539 MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000363676
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    Find genes that share ontologies with RPL23           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL23 (RL23)

    3 DrugBank Compounds for RPL23    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ANISOMYCIN-- --target--10592235
    Alpha-Hydroxy-Beta-Phenyl-Propionic Acid-- --target--10592235
    PUROMYCIN-- --target--10592235

    1 Novoseek inferred chemical compound relationship for RPL23 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 20.3 1 17498616 (1)



    Find genes that share compounds with RPL23           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPL23 gene: 
    NM_000978.3  

    Unigene Cluster for RPL23:

    Ribosomal protein L23
    Hs.406300  [show with all ESTs]
    Unigene Representative Sequence: BI912181
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394332 ENST00000394333 ENST00000479035(uc002hqx.1) ENST00000245857
    ENST00000584912(uc002hqy.1) ENST00000584583 ENST00000577407 ENST00000470646
    ENST00000378096 ENST00000577760(uc002hqz.1) ENST00000584056
    miRNA
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    Block miRNA regulation of human, mouse, rat RPL23 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RPL23:
    hsa-miR-520d-5p hsa-miR-524-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RPL23
    Predesigned siRNA for gene silencing in human, mouse, rat RPL23
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    GenScript: all cDNA clones in your preferred vector: RPL23 (NM_000984)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat RPL23
      QuantiFast Probe-based Assays in human, mouse, rat RPL23

    Additional mRNA sequence: 

    AK024749.1 BC003518.1 BC010114.2 BC062716.1 BC104651.1 BC106061.1 X52839.1 X55954.1 

    Selected DOTS entries (see all 82):

    DT.100060178  DT.92411435  DT.101956171  DT.101956165  DT.97761831  DT.305780  DT.100728060  DT.100848722 
    DT.100728071  DT.101956164  DT.120905906  DT.100728093  DT.100673704  DT.91771028  DT.95169960  DT.120905858 
    DT.95169812  DT.120905949  DT.120905849  DT.120905869  DT.100728090  DT.120905918  DT.95242891  DT.95088660 

    Selected AceView cDNA sequences (see all 2012):

    CN485057 AA337797 AA628764 W00983 AA335070 BM798388 AJ714983 AA369017 
    AA492147 AW304672 BQ348226 AA316430 BE894290 BE293031 AA131211 BU783331 
    CR604268 CA334955 F32409 F29669 BE296167 BE327741 CA427142 AA730834 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPL23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCTCCAGT
    RPL23 Expression
    About this image


    RPL23 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    RPL23 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL23 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406300
        Custom PCR Arrays for RPL23
    Primer
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    OriGene qPCR primer pairs and template standards for RPL23
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL23 gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl231 , 5 ribosomal protein L231, 5 91.19(n)1
    100(a)1
      11 (61.10 cM)5
    650191  NM_022891.31  NP_075029.11 
     977775275 
    chicken
    (Gallus gallus)
    Aves RPL231 ribosomal protein L23 82.62(n)
    100(a)
      420001  XM_418122.4  XP_418122.3 
    lizard
    (Anolis carolinensis)
    Reptilia RPL236
    ribosomal protein L23
    100(a)
    1 ↔ 1
    6(63165305-63174093)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.80932 Xenopus laevis transcribed sequence with strong similarity more 81.05(n)    48059473 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059509.12   -- 84.2(n)   393705  BC059509.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL17A3
    RpL231
    protein biosynthesis structural
    constituent of more3
    Ribosomal protein L231
    85(a)3
    73.57(n)1
    88.57(a)1
      59B33
    376281  NM_079089.31  NP_523813.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-231 , 3 rpl-231 86(a)3
    72.62(n)1
    86.43(a)1
      III(5777300-5778157)3
    1757961  NM_065830.41  NP_498231.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL23B(YER117W)4
    RPL23B1
    Protein component of the large (60S) ribosomal subunit, more4
    RPL23B1
    68.43(n)1
    80.3(a)1
      5(396769-397653)4
    8568531, 4  NP_011042.31  NP_011042.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G333701 AT2G33370 74.58(n)
    84.89(a)
      817900  NM_128897.3  NP_180895.1 
    rice
    (Oryza sativa)
    Liliopsida AK121994.12   -- 77.36(n)    AK121994.1 


    ENSEMBL Gene Tree for RPL23 (if available)
    TreeFam Gene Tree for RPL23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPL23 gene
    1 SIMAP similar gene for RPL23 using alignment to 6 protein entries:     RL23_HUMAN (see all proteins):
    LOC222901

    Find genes that share paralogs with RPL23           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RPL23 (see all 12)
    PGOHUM00000238719 PGOHUM00000244766 PGOHUM00000239060 PGOHUM00000241114 PGOHUM00000241117


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPL23 (see all 77)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480045771,2
    C--37005878(+) GCTACA/CGCGCC 1 -- ds50010--------
    rs1166095191,2
    C,F--37005955(+) CTACTA/GTTATT 1 -- ds50012Minor allele frequency- G:0.02WA NS 262
    rs1925363451,2
    C--37005976(+) AAAACA/CCAAAT 1 -- ds50010--------
    rs12391761,2
    C,F,A,H--37006131(+) CACTGT/CAGAGG 1 -- ds5001 ese329Minor allele frequency- C:0.48NS EA NA WA CSA 2632
    rs116562601,2
    C,H--37006251(+) CTGTAG/ATCCCA 1 -- ds5001 ese31Minor allele frequency- A:0.00NA 2
    rs1416537671,2
    --37006328(+) CAAACA/GAATAC 1 -- ut310--------
    rs1126179791,2
    C--37006339(+) TTTTTA/TATGGG 1 -- ut310--------
    rs1135990161,2
    C--37006340(+) TTTTAA/TTGGGT 1 -- ut310--------
    rs2006406041,2
    --37006344(+) AATGGA/GTTTAG 1 -- ut310--------
    rs38345631,2
    C--37006350(+) TTTAG-/TTTTTTT 1 -- ut312Minor allele frequency- TT:0.11NA NS 142

    HapMap Linkage Disequilibrium report for RPL23 (37004118 - 37010096 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RPL23:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908199CNV Loss21882294
    nsv833439CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL23
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603662    OMIM disorders: --


    Find genes that share disorders with RPL23           About GenesLikeMe


    Export disorders for RPL23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPL23 gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with RPL23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17. (PubMed id 1861993)1, 2, 3 Herault Y.... Brun G. (Nucleic Acids Res. 1991)
    2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    5. Isolation and analysis of a human cDNA highly homologous to the yeast gene encoding L17A ribosomal protein. (PubMed id 1874450)1, 2 Berchtold M.W. and Berger M.C. (Gene 1991)
    6. Inhibition of HDM2 and activation of p53 by ribosomal protein L23. (PubMed id 15314174)1, 9 Jin A....Zhang Y. (Mol. Cell. Biol. 2004)
    7. Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. (PubMed id 15314173)1, 9 Dai M.S....Lu H. (Mol. Cell. Biol. 2004)
    8. A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. (PubMed id 19160485)1, 9 Wanzel M....Eilers M. (Nat. Cell Biol. 2008)
    9. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9349 HGNC: 10316 AceView: RPL23 Ensembl:ENSG00000125691 euGenes: HUgn9349
    ECgene: RPL23 Kegg: 9349 H-InvDB: RPL23

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPL23 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPL23 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPL23 gene:
    Search GeneIP for patents involving RPL23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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