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Aliases for RPL23 Gene

Aliases for RPL23 Gene

  • Ribosomal Protein L23 2 3 5
  • 60S Ribosomal Protein L17 3 4
  • 60S Ribosomal Protein L23 3
  • Ribosomal Protein L17 3
  • RpL17 3
  • L23 3

External Ids for RPL23 Gene

Previous GeneCards Identifiers for RPL23 Gene

  • GC17M036491
  • GC17M039004
  • GC17M036914
  • GC17M037381
  • GC17M034259
  • GC17M037005

Summaries for RPL23 Gene

Entrez Gene Summary for RPL23 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL23 Gene

RPL23 (Ribosomal Protein L23) is a Protein Coding gene. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL23 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL23 Gene

Genomics for RPL23 Gene

Regulatory Elements for RPL23 Gene

Enhancers for RPL23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F038823 1.2 ENCODE 41.6 +28.9 28906 3.0 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MED1 ENSG00000266469 CDK12 ENSG00000275532 SNORA21 RPL23 ENSG00000275665 RPL19 PIP4K2B CWC25
GH17F038850 1.5 FANTOM5 ENCODE 28.6 +0.3 345 5.2 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 RPL23 ENSG00000266469 CDK12 SNORA21 PCGF2 ERBB2 ENSG00000276170 ENSG00000275532 RPL19 MED1
GH17F038584 1.3 Ensembl ENCODE 31.7 +268.8 268830 1.7 ATF1 ZNF493 ARID4B GLI4 DMAP1 ZNF48 ZNF2 ZNF121 GLIS2 ZNF143 MED1 ENSG00000266469 RPL23 SNORA21 ENSG00000275532 CDK12 LINC02079 RPL19 ENSG00000274996 LOC105371761
GH17F038745 1.2 ENCODE 21.9 +104.1 104070 8.6 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 CDK12 ENSG00000266469 MED1 ENSG00000275665 PCGF2 ENSG00000275532 SNORA21 RPL23 ENSG00000277969 CISD3
GH17F039191 1.2 ENCODE 16.2 -343.2 -343155 11.7 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 RPL23 CDK12 SNORD124 ENSG00000266469 PGAP3 SNORA21 MSL1 ERBB2 RPL19 STAC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL23 on UCSC Golden Path with GeneCards custom track

Promoters for RPL23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001535662 643 2801 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for RPL23 Gene

Chromosome:
17
Start:
38,847,865 bp from pter
End:
38,853,843 bp from pter
Size:
5,979 bases
Orientation:
Minus strand

Genomic View for RPL23 Gene

Genes around RPL23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL23 Gene

Proteins for RPL23 Gene

  • Protein details for RPL23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62829-RL23_HUMAN
    Recommended name:
    60S ribosomal protein L23
    Protein Accession:
    P62829
    Secondary Accessions:
    • P23131
    • P24048
    • Q29246
    • Q3SWV7
    • Q6P5S1

    Protein attributes for RPL23 Gene

    Size:
    140 amino acids
    Molecular mass:
    14865 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL23 Gene

neXtProt entry for RPL23 Gene

Post-translational modifications for RPL23 Gene

  • Ubiquitination at Lys 35, Lys 43, Lys 66, Lys 75, and Lys 123
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL23 Gene

No data available for DME Specific Peptides for RPL23 Gene

Domains & Families for RPL23 Gene

Gene Families for RPL23 Gene

Protein Domains for RPL23 Gene

Suggested Antigen Peptide Sequences for RPL23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62829

UniProtKB/Swiss-Prot:

RL23_HUMAN :
  • Belongs to the ribosomal protein L14P family.
Family:
  • Belongs to the ribosomal protein L14P family.
genes like me logo Genes that share domains with RPL23: view

Function for RPL23 Gene

Gene Ontology (GO) - Molecular Function for RPL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0070180 large ribosomal subunit rRNA binding IBA --
genes like me logo Genes that share ontologies with RPL23: view
genes like me logo Genes that share phenotypes with RPL23: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL23 Gene

Localization for RPL23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL23 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RPL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA,NAS 1874450
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with RPL23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL23 Gene

Pathways & Interactions for RPL23 Gene

genes like me logo Genes that share pathways with RPL23: view

Pathways by source for RPL23 Gene

1 KEGG pathway for RPL23 Gene
1 GeneGo (Thomson Reuters) pathway for RPL23 Gene

Gene Ontology (GO) - Biological Process for RPL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006610 ribosomal protein import into nucleus NAS 1874450
genes like me logo Genes that share ontologies with RPL23: view

No data available for SIGNOR curated interactions for RPL23 Gene

Drugs & Compounds for RPL23 Gene

(4) Drugs for RPL23 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL23: view

Transcripts for RPL23 Gene

Unigene Clusters for RPL23 Gene

Ribosomal protein L23:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL23 Gene

No ASD Table

Relevant External Links for RPL23 Gene

GeneLoc Exon Structure for
RPL23
ECgene alternative splicing isoforms for
RPL23

Expression for RPL23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL23 Gene

This gene is overexpressed in Bone (7.5) and Bone marrow mesenchymal stem cell (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL23 Gene



Protein tissue co-expression partners for RPL23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL23 Gene:

RPL23

SOURCE GeneReport for Unigene cluster for RPL23 Gene:

Hs.406300
genes like me logo Genes that share expression patterns with RPL23: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL23 Gene

Orthologs for RPL23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL23 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia RPL23 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL23 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPL23 34 35
  • 99.52 (n)
cow
(Bos Taurus)
Mammalia RPL23 34 35
  • 93.57 (n)
rat
(Rattus norvegicus)
Mammalia Rpl23 34
  • 92.86 (n)
dog
(Canis familiaris)
Mammalia RPL23 34 35
  • 92.38 (n)
mouse
(Mus musculus)
Mammalia Rpl23 34 16 35
  • 91.19 (n)
chicken
(Gallus gallus)
Aves RPL23 34 35
  • 82.62 (n)
lizard
(Anolis carolinensis)
Reptilia RPL23 35
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl23 34
  • 81.19 (n)
Str.17122 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8093 34
zebrafish
(Danio rerio)
Actinopterygii rpl23 34 35
  • 84.05 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta RpL17A 36
  • 85 (a)
RpL23 34 35
  • 73.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010252 34
  • 73.57 (n)
worm
(Caenorhabditis elegans)
Secernentea rpl-23 36 34 35
  • 72.62 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL23A 35
  • 79 (a)
OneToMany
RPL23B 34 35 37
  • 68.43 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL288W 34
  • 68.69 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06997g 34
  • 67.93 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G33370 34
  • 74.58 (n)
soybean
(Glycine max)
eudicotyledons Gma.5613 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6927 34
rice
(Oryza sativa)
Liliopsida Os02g0814700 34
  • 72.66 (n)
corn
(Zea mays)
Liliopsida Zm.12634 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7198 35
  • 86 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU02905 34
  • 69.32 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2301 34
  • 68.14 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5835 34
Species where no ortholog for RPL23 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL23 Gene

ENSEMBL:
Gene Tree for RPL23 (if available)
TreeFam:
Gene Tree for RPL23 (if available)

Paralogs for RPL23 Gene

No data available for Paralogs for RPL23 Gene

Variants for RPL23 Gene

Sequence variations from dbSNP and Humsavar for RPL23 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111254587 -- 38,852,300(+) GCGGA(A/G)GTTGC intron-variant
rs111390718 -- 38,855,344(+) CACCC(A/G/T)GGGAG upstream-variant-2KB
rs112235635 -- 38,852,685(+) GTTCA(A/G)CCGTC downstream-variant-500B, reference, synonymous-codon
rs112276704 -- 38,852,132(+) CAGGA(C/G)AATCT intron-variant
rs1124927 -- 38,853,877(+) GCCCT(C/G)TCTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL23 Gene

Variant ID Type Subtype PubMed ID
nsv833439 CNV loss 17160897
nsv1146669 OTHER inversion 26484159

Variation tolerance for RPL23 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL23 Gene

Disorders for RPL23 Gene

Relevant External Links for RPL23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL23

No disorders were found for RPL23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL23 Gene

Publications for RPL23 Gene

  1. cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17. (PMID: 1861993) Herault Y. … Brun G. (Nucleic Acids Res. 1991) 2 3 4 64
  2. A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. (PMID: 19160485) Wanzel M. … Eilers M. (Nat. Cell Biol. 2008) 3 22 64
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. (PMID: 15314173) Dai M.S. … Lu H. (Mol. Cell. Biol. 2004) 3 22 64

Products for RPL23 Gene

Sources for RPL23 Gene

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