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Aliases for RPL23 Gene

Aliases for RPL23 Gene

  • Ribosomal Protein L23 2 3
  • 60S Ribosomal Protein L17 3 4
  • 60S Ribosomal Protein L23 3
  • Ribosomal Protein L17 3
  • RpL17 3
  • L23 3

External Ids for RPL23 Gene

Previous GeneCards Identifiers for RPL23 Gene

  • GC17M036491
  • GC17M039004
  • GC17M036914
  • GC17M037381
  • GC17M034259
  • GC17M037005

Summaries for RPL23 Gene

Entrez Gene Summary for RPL23 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL23 Gene

RPL23 (Ribosomal Protein L23) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPL23 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL23 Gene

Genomics for RPL23 Gene

Regulatory Elements for RPL23 Gene

Genomic Location for RPL23 Gene

Start:
38,847,865 bp from pter
End:
38,853,843 bp from pter
Size:
5,979 bases
Orientation:
Minus strand

Genomic View for RPL23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL23 Gene

Proteins for RPL23 Gene

  • Protein details for RPL23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62829-RL23_HUMAN
    Recommended name:
    60S ribosomal protein L23
    Protein Accession:
    P62829
    Secondary Accessions:
    • P23131
    • P24048
    • Q29246
    • Q3SWV7
    • Q6P5S1

    Protein attributes for RPL23 Gene

    Size:
    140 amino acids
    Molecular mass:
    14865 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL23 Gene

neXtProt entry for RPL23 Gene

Proteomics data for RPL23 Gene at MOPED

Post-translational modifications for RPL23 Gene

  • Ubiquitination at Lys35, Lys43, Lys66, Lys75, and Lys123
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL23 Gene

No data available for DME Specific Peptides for RPL23 Gene

Domains for RPL23 Gene

Gene Families for RPL23 Gene

HGNC:
  • RPL :L ribosomal proteins

Protein Domains for RPL23 Gene

Suggested Antigen Peptide Sequences for RPL23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62829

UniProtKB/Swiss-Prot:

RL23_HUMAN :
  • P62829
Family:
  • Belongs to the ribosomal protein L14P family.
genes like me logo Genes that share domains with RPL23: view

Function for RPL23 Gene

Gene Ontology (GO) - Molecular Function for RPL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL23: view
genes like me logo Genes that share phenotypes with RPL23: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL23 Gene

Localization for RPL23 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL23 Gene COMPARTMENTS Subcellular localization image for RPL23 gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RPL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome NAS 1874450
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with RPL23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL23 Gene

Pathways for RPL23 Gene

genes like me logo Genes that share pathways with RPL23: view

Pathways by source for RPL23 Gene

1 KEGG pathway for RPL23 Gene
1 GeneGo (Thomson Reuters) pathway for RPL23 Gene

Gene Ontology (GO) - Biological Process for RPL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL23: view

Compounds for RPL23 Gene

(3) Drugbank Compounds for RPL23 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
target
ANISOMYCIN
target
PUROMYCIN
target

(1) Novoseek inferred chemical compound relationships for RPL23 Gene

Compound -log(P) Hits PubMed IDs
serine 20.3 1
genes like me logo Genes that share compounds with RPL23: view

Transcripts for RPL23 Gene

Unigene Clusters for RPL23 Gene

Ribosomal protein L23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL23 Gene

No ASD Table

Relevant External Links for RPL23 Gene

GeneLoc Exon Structure for
RPL23
ECgene alternative splicing isoforms for
RPL23

Expression for RPL23 Gene

mRNA expression in normal human tissues for RPL23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL23 Gene

SOURCE GeneReport for Unigene cluster for RPL23 Gene Hs.406300

genes like me logo Genes that share expressions with RPL23: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL23 Gene

Orthologs for RPL23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL23 35
  • 99.52 (n)
  • 100 (a)
RPL23 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPL23 35
  • 93.57 (n)
  • 99.29 (a)
RPL23 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL23 35
  • 92.38 (n)
  • 100 (a)
RPL23 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl23 35
  • 91.19 (n)
  • 100 (a)
Rpl23 16
Rpl23 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPL23 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL23 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl23 35
  • 92.86 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPL23 35
  • 82.62 (n)
  • 100 (a)
RPL23 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL23 36
  • 100 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8093 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl23 35
  • 81.19 (n)
  • 100 (a)
Str.17122 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
rpl23 35
  • 84.05 (n)
  • 99.29 (a)
rpl23 36
  • 99 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010252 35
  • 73.57 (n)
  • 91.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL23 35
  • 73.57 (n)
  • 88.57 (a)
RpL23 36
  • 89 (a)
OneToOne
RpL17A 37
  • 85 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-23 35
  • 72.62 (n)
  • 86.43 (a)
rpl-23 36
  • 86 (a)
OneToOne
rpl-23 37
  • 86 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL288W 35
  • 68.69 (n)
  • 78.79 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL23A 36
  • 79 (a)
OneToMany
RPL23B 35
  • 68.43 (n)
  • 80.3 (a)
RPL23B 36
  • 79 (a)
OneToMany
RPL23B 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06997g 35
  • 67.93 (n)
  • 78.79 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6927 35
soybean
(Glycine max)
eudicotyledons Gma.5613 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G33370 35
  • 74.58 (n)
  • 84.89 (a)
corn
(Zea mays)
Liliopsida Zm.12634 35
rice
(Oryza sativa)
Liliopsida Os02g0814700 35
  • 72.66 (n)
  • 84.17 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02905 35
  • 69.32 (n)
  • 77.54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2301 35
  • 68.14 (n)
  • 78.68 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5835 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7198 36
  • 86 (a)
OneToOne
Species with no ortholog for RPL23:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL23 Gene

ENSEMBL:
Gene Tree for RPL23 (if available)
TreeFam:
Gene Tree for RPL23 (if available)

Paralogs for RPL23 Gene

Selected SIMAP similar genes for RPL23 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RPL23: view

No data available for Paralogs for RPL23 Gene

Variants for RPL23 Gene

Sequence variations from dbSNP and Humsavar for RPL23 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1239176 -- 38,849,878(+) CACTG(C/T)AGAGG downstream-variant-500B
rs1239177 -- 38,850,750(+) GAGTA(A/T)AGGCA intron-variant
rs1239178 -- 38,850,866(+) CACCT(C/T)ACAGG intron-variant
rs3208731 -- 38,850,108(-) AAAAA(A/T)AAAAA utr-variant-3-prime
rs3834563 -- 38,850,097(+) TTTAG(-/TT)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL23 Gene

Variant ID Type Subtype PubMed ID
nsv833439 CNV Loss 17160897
nsv908199 CNV Loss 21882294

Relevant External Links for RPL23 Gene

HapMap Linkage Disequilibrium report
RPL23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL23 Gene

Disorders for RPL23 Gene

No disorders were found for RPL23 Gene.

No data available for UniProtKB/Swiss-Prot for RPL23 Gene

Publications for RPL23 Gene

  1. cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17. (PMID: 1861993) Herault Y. … Brun G. (Nucleic Acids Res. 1991) 2 3 4
  2. Isolation and analysis of a human cDNA highly homologous to the yeast gene encoding L17A ribosomal protein. (PMID: 1874450) Berchtold M.W. … Berger M.C. (Gene 1991) 3 4
  3. A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. (PMID: 19160485) Wanzel M. … Eilers M. (Nat. Cell Biol. 2008) 3 23
  4. Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. (PMID: 15314173) Dai M.S. … Lu H. (Mol. Cell. Biol. 2004) 3 23
  5. Inhibition of HDM2 and activation of p53 by ribosomal protein L23. (PMID: 15314174) Jin A. … Zhang Y. (Mol. Cell. Biol. 2004) 3 23

Products for RPL23 Gene

Sources for RPL23 Gene

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