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Aliases for RPL22L1 Gene

Aliases for RPL22L1 Gene

  • Ribosomal Protein L22-Like 1 2 3

External Ids for RPL22L1 Gene

Previous GeneCards Identifiers for RPL22L1 Gene

  • GC03M172067
  • GC03M170582
  • GC03M167952

Summaries for RPL22L1 Gene

GeneCards Summary for RPL22L1 Gene

RPL22L1 (Ribosomal Protein L22-Like 1) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL22.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL22L1 Gene

Genomics for RPL22L1 Gene

Regulatory Elements for RPL22L1 Gene

Genomic Location for RPL22L1 Gene

170,864,875 bp from pter
170,870,483 bp from pter
5,609 bases
Minus strand

Genomic View for RPL22L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL22L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL22L1 Gene

Proteins for RPL22L1 Gene

  • Protein details for RPL22L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L22-like 1
    Protein Accession:
    Secondary Accessions:
    • Q32Q77

    Protein attributes for RPL22L1 Gene

    122 amino acids
    Molecular mass:
    14607 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH62731.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RPL22L1 Gene

Proteomics data for RPL22L1 Gene at MOPED

Post-translational modifications for RPL22L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPL22L1 Gene

No data available for DME Specific Peptides for RPL22L1 Gene

Domains for RPL22L1 Gene

Protein Domains for RPL22L1 Gene


Suggested Antigen Peptide Sequences for RPL22L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6P5R6
  • Belongs to the ribosomal protein L22e family.
genes like me logo Genes that share domains with RPL22L1: view

No data available for Gene Families for RPL22L1 Gene

Function for RPL22L1 Gene

Gene Ontology (GO) - Molecular Function for RPL22L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with RPL22L1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RPL22L1 Gene

Localization for RPL22L1 Gene

Subcellular locations from

Jensen Localization Image for RPL22L1 Gene COMPARTMENTS Subcellular localization image for RPL22L1 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL22L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL22L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL22L1 Gene

Pathways for RPL22L1 Gene

SuperPathways for RPL22L1 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
genes like me logo Genes that share pathways with RPL22L1: view

Pathways by source for RPL22L1 Gene

1 KEGG pathway for RPL22L1 Gene

Gene Ontology (GO) - Biological Process for RPL22L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
genes like me logo Genes that share ontologies with RPL22L1: view

Transcripts for RPL22L1 Gene

Unigene Clusters for RPL22L1 Gene

Ribosomal protein L22-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL22L1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for RPL22L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL22L1 Gene

mRNA expression in normal human tissues for RPL22L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL22L1 Gene

SOURCE GeneReport for Unigene cluster for RPL22L1 Gene Hs.380933

genes like me logo Genes that share expressions with RPL22L1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL22L1 Gene

Orthologs for RPL22L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL22L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL22L1 35
  • 99.73 (n)
  • 99.18 (a)
RPL22L1 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 87 (a)
-- 36
  • 89 (a)
RPL22L1 36
  • 96 (a)
(Canis familiaris)
Mammalia RPL22L1 35
  • 93.94 (n)
  • 97.52 (a)
RPL22L1 36
  • 97 (a)
(Mus musculus)
Mammalia Rpl22l1 16
Rpl22l1 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia RPL22L1 36
  • 79 (a)
(Rattus norvegicus)
Mammalia Rpl22l2 35
  • 92.62 (n)
  • 95.08 (a)
(Gallus gallus)
Aves RPL22L1 36
  • 78 (a)
(Anolis carolinensis)
Reptilia RPL22L1 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl22l1 35
  • 76.67 (n)
  • 85 (a)
Str.15461 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13594 35
(Danio rerio)
Actinopterygii rpl22l1 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL22 36
  • 21 (a)
RpL22-like 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea rpl-22 36
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL22A 36
  • 45 (a)
RPL22B 36
  • 39 (a)
RPL22B 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4506 36
  • 61 (a)
CSA.5709 36
  • 61 (a)
Species with no ortholog for RPL22L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL22L1 Gene

Gene Tree for RPL22L1 (if available)
Gene Tree for RPL22L1 (if available)

Paralogs for RPL22L1 Gene

Paralogs for RPL22L1 Gene

Selected SIMAP similar genes for RPL22L1 Gene using alignment to 4 proteins: Pseudogenes for RPL22L1 Gene

genes like me logo Genes that share paralogs with RPL22L1: view

Variants for RPL22L1 Gene

Sequence variations from dbSNP and Humsavar for RPL22L1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs13462 - 170,866,460(-) GAGTG(G/T)TTGCA reference, missense
rs1818533 -- 170,864,547(-) tgaga(C/T)ggagt downstream-variant-500B
rs3732927 -- 170,868,268(-) TTTTT(A/G)TAATC intron-variant
rs3821747 -- 170,867,828(-) ATTTA(C/T)TGCTA intron-variant
rs11919564 -- 170,867,619(+) AATGG(C/T)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL22L1 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv877978 CNV Loss 21882294

Relevant External Links for RPL22L1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL22L1 Gene

Disorders for RPL22L1 Gene

Relevant External Links for RPL22L1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RPL22L1: view

No data available for UniProtKB/Swiss-Prot for RPL22L1 Gene

Publications for RPL22L1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  4. Proteomic analysis of rodent ribosomes revealed heterogeneity including ribosomal proteins L10-like, L22-like 1, and L39-like. (PMID: 20063902) Sugihara Y. … Nadano D. (J. Proteome Res. 2010) 23
  5. The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. (PMID: 8076819) Matoba R. … Matsubara K. (Gene 1994) 3

Products for RPL22L1 Gene

Sources for RPL22L1 Gene

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