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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL22L1 Gene

protein-coding   GIFtS: 48
GCID: GC03M170582

Ribosomal Protein L22-Like 1

  Search for RPL22L1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein L22-Like 11 2
60S Ribosomal Protein L22-Like 12

External Ids:    HGNC: 276101   Entrez Gene: 2009162   Ensembl: ENSG000001635847   UniProtKB: Q6P5R63   

Export aliases for RPL22L1 gene to outside databases

Previous GC identifers: GC03M172067 GC03M167952


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RPL22L1 Gene: 
RPL22L1 (ribosomal protein L22-like 1) is a protein-coding gene. Among its related super-pathways are Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL22.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL22L1 gene promoter:
         STAT5B   SRF   NF-1   Pax-5   SRF (504 AA)   Nkx2-5   LCR-F1   HNF-3beta   AREB6   Nkx6-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RPL22L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL22L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2   Ensembl cytogenetic band:  3q26.2   HGNC cytogenetic band: 3q26.2

RPL22L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL22L1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M170582:  view genomic region     (about GC identifiers)

Start:
170,582,664 bp from pter      End:
170,588,272 bp from pter
Size:
5,609 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RL22L_HUMAN, Q6P5R6 (See protein sequence)
Recommended Name: 60S ribosomal protein L22-like 1  
Size: 122 amino acids; 14607 Da
Sequence caution: Sequence=AAH62731.1; Type=Erroneous initiation;
Secondary accessions: Q32Q77

Explore the universe of human proteins at neXtProt for RPL22L1: NX_Q6P5R6

Explore proteomics data for RPL22L1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6P5R6

  • RPL22L1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPL22L1 Protein Expression
    REFSEQ proteins: NP_001093115.1  
    ENSEMBL proteins: 
     ENSP00000346080   ENSP00000418909   ENSP00000419713   ENSP00000420039   ENSP00000419041  

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    Cloud-Clone Corp. Proteins for RPL22L1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005840ribosome IEA--

    RPL22L1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002671 Ribosomal_L22e

    Graphical View of Domain Structure for InterPro Entry Q6P5R6

    ProtoNet protein and cluster: Q6P5R6

    1 Blocks protein domain: IPB002671 Ribosomal L22e protein

    UniProtKB/Swiss-Prot: RL22L_HUMAN, Q6P5R6
    Similarity: Belongs to the ribosomal protein L22e family


    RPL22L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
         
    RPL22L1 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPL22L1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Ribosome0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for RPL22L1):
        Ribosome


    RPL22L1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL22L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for RPL22L1 (Q6P5R63 ENSP000003460804) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    G3BP2Q9UN863, ENSP000003527384I2D: score=2 STRING: ENSP00000352738
    USP39Q53GS93, ENSP000003129814I2D: score=2 STRING: ENSP00000312981
    C12orf44Q9BSB43I2D: score=1 
    PDPK1O155303I2D: score=1 
    PRKAA1Q131313I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--

    RPL22L1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL22L1 (RL22L)

    Search CenterWatch for drugs/clinical trials and news about RPL22L1 / RL22L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPL22L1 gene: 
    NM_001099645.1  

    Unigene Cluster for RPL22L1:

    Ribosomal protein L22-like 1
    Hs.380933  [show with all ESTs]
    Unigene Representative Sequence: NM_001099645
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295830(uc003fhc.4 uc003fhb.4) ENST00000478578 ENST00000475836
    ENST00000466674 ENST00000494771 ENST00000463836
    miRNA
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    Products:
         
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    Additional mRNA sequence: 

    BC062731.1 BC107708.1 

    4 DOTS entries:

    DT.101955341  DT.97843444  DT.421250  DT.92415078 

    24/170 AceView cDNA sequences (see all 170):

    CF528704 BC062731 AI432365 AI708626 AI300800 CK822083 AA554691 AA188378 
    AJ712808 AA397968 AA721457 AA313040 AA308664 BX332164 BM786678 AA316016 
    AW117957 BF984449 AI830845 AA766192 AA527902 AW006731 AL110170 AA724213 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RPL22L1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:              -           -                     
    SP2:              -                                 
    SP3:              -           -                     
    SP4:                          -                     


    ECgene alternative splicing isoforms for RPL22L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL22L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAATACCA
    RPL22L1 Expression
    About this image


    See RPL22L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL22L1

    SOURCE GeneReport for Unigene cluster: Hs.380933
        SABiosciences Custom PCR Arrays for RPL22L1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL22L1 gene from 9/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl22l11 , 5 ribosomal protein L22 like 11, 5 93.17(n)1
    95.9(a)1
      3 (12.27 cM)5
    680281  NM_026517.21  NP_080793.11 
     288055115 
    chicken
    (Gallus gallus)
    Aves LOC1008582961 60S ribosomal protein L22-like 1-like 80.05(n)
    88.52(a)
      100858296  XM_003641777.1  XP_003641825.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPL22L16
    Uncharacterized protein
    84(a)
    1 ↔ 1
    3(7381107-7386009)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.154612 Transcribed sequence with moderate similarity to protein more 77.49(n)    142023463 
    zebrafish
    (Danio rerio)
    Actinopterygii rpl22l11 ribosomal protein L22-like 1 71.58(n)
    77.05(a)
      735250  NM_001045335.2  NP_001038800.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL226
    RpL22-like6
    Ribosomal protein L22-like
    22(a)
    14(a)
    many ↔ many
    many ↔ many
    X(656593-659172)
    2R(19134133-19135410)
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-226
    60S ribosomal protein L22
    53(a)
    1 → many
    II(5055614-5056217)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL22B(YFL034C-A)4
    RPL22B1
    Protein component of the large (60S) ribosomal subunit, more4
    Rpl22bp1
    51.24(n)1
    42.15(a)1
      6(64932-64243)4
    8505091, 4  NP_116619.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G028301 large subunit ribosomal protein L22e 60.12(n)
    57.14(a)
      838098  NM_100164.1  NP_171782.1 


    ENSEMBL Gene Tree for RPL22L1 (if available)
    TreeFam Gene Tree for RPL22L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL22L1 gene
    RPL222  
    2 SIMAP similar genes for RPL22L1 using alignment to 4 protein entries:     RL22L_HUMAN (see all proteins):
    RPL22    DKFZp586O1224

    RPL22L1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RPL22L1
    PGOHUM00000245912 PGOHUM00000246156


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/206 SNPs in RPL22L1 are shown (see all 206)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1382845251,2
    --170582166(+) AAATCC/TCATCT 1 -- int10--------
    rs1496223161,2
    --170582170(+) CTCATA/CTCTAC 1 -- int10--------
    rs1174363591,2
    C,F--170582185(+) AAAAAT/AACAAA 1 -- int11Minor allele frequency- A:0.03EA 120
    rs746912721,2
    C,F--170582202(+) CTGGGC/AGTGGG 1 -- int15Minor allele frequency- A:0.08NA CSA WA EA 362
    rs1472950051,2
    C--170582284(+) TGCAGA/TGAGCC 1 -- int10--------
    rs1448001221,2
    C--170582324(+) CAACG-/AAGTGA 1 -- int10--------
    rs18185331,2
    C,F--170582336(-) tgagaC/Tggagt 1 -- int111Minor allele frequency- T:0.45NA WA CSA EA 374
    rs1404434561,2
    --170582338(+) TCCATC/GTCAAA 1 -- int10--------
    rs1443055661,2
    --170582358(+) AACAAA/CAAATC 1 -- int10--------
    rs1473540021,2
    --170582401(+) AATGCA/GTATCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RPL22L1 (170582664 - 170588272 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RPL22L1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv877978CNV Loss21882294
    nsv7356OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RPL22L1 for disorders           About MalaCards

    RPL22L1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RPL22L1
    Human Genome Epidemiology (HuGE) Navigator: RPL22L1 (1 document)

    Export disorders for RPL22L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL22L1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with RPL22L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    4. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 200916 HGNC: 27610 AceView: LOC200916 Ensembl:ENSG00000163584 euGenes: HUgn200916
    ECgene: RPL22L1 Kegg: 200916 H-InvDB: RPL22L1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL22L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPL22L1 gene:
    Search GeneIP for patents involving RPL22L1

    GeneCards and IP:
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