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Aliases for RPL22 Gene

Aliases for RPL22 Gene

  • Ribosomal Protein L22 2 3 5
  • Epstein-Barr Virus Small RNA-Associated Protein 3 4
  • Heparin-Binding Protein HBp15 3 4
  • EBER-Associated Protein 3 4
  • EAP 3 4
  • Epstein-Barr-Encoded RNA-Associated Protein 3
  • Heparin-Binding Protein 15 3
  • HBP15/L22 3
  • HBP15 3
  • L22 3

External Ids for RPL22 Gene

Previous GeneCards Identifiers for RPL22 Gene

  • GC01M005823
  • GC01M006053
  • GC01M005956
  • GC01M005955
  • GC01M005393

Summaries for RPL22 Gene

Entrez Gene Summary for RPL22 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL22 Gene

RPL22 (Ribosomal Protein L22) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome. An important paralog of this gene is RPL22L1.

Gene Wiki entry for RPL22 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL22 Gene

Genomics for RPL22 Gene

Regulatory Elements for RPL22 Gene

Enhancers for RPL22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPL22 on UCSC Golden Path with GeneCards custom track

Promoters for RPL22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL22 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL22 Gene

6,181,269 bp from pter
6,209,389 bp from pter
28,121 bases
Minus strand

Genomic View for RPL22 Gene

Genes around RPL22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL22 Gene

Proteins for RPL22 Gene

  • Protein details for RPL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L22
    Protein Accession:
    Secondary Accessions:
    • B2R495
    • Q6IBD1

    Protein attributes for RPL22 Gene

    128 amino acids
    Molecular mass:
    14787 Da
    Quaternary structure:
    No Data Available
    • Binds to Epstein-Barr virus small RNAs and to heparin.

    Three dimensional structures from OCA and Proteopedia for RPL22 Gene

neXtProt entry for RPL22 Gene

Proteomics data for RPL22 Gene at MOPED

Post-translational modifications for RPL22 Gene

  • Ubiquitination at Lys 52, Lys 69, and Lys 107
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL22 Gene

No data available for DME Specific Peptides for RPL22 Gene

Domains & Families for RPL22 Gene

Gene Families for RPL22 Gene

Protein Domains for RPL22 Gene


Suggested Antigen Peptide Sequences for RPL22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L22e family.
  • Belongs to the ribosomal protein L22e family.
genes like me logo Genes that share domains with RPL22: view

Function for RPL22 Gene

Molecular function for RPL22 Gene

GENATLAS Biochemistry:
60S ribosomal protein L22,14kDa

Gene Ontology (GO) - Molecular Function for RPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22720776
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with RPL22: view
genes like me logo Genes that share phenotypes with RPL22: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RPL22

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL22 Gene

Localization for RPL22 Gene

Subcellular locations from

Jensen Localization Image for RPL22 Gene COMPARTMENTS Subcellular localization image for RPL22 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
chloroplast 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RPL22 Gene

Pathways & Interactions for RPL22 Gene

genes like me logo Genes that share pathways with RPL22: view

Pathways by source for RPL22 Gene

1 KEGG pathway for RPL22 Gene
1 GeneGo (Thomson Reuters) pathway for RPL22 Gene

SIGNOR curated interactions for RPL22 Gene


Gene Ontology (GO) - Biological Process for RPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL22: view

Drugs & Compounds for RPL22 Gene

(3) Drugs for RPL22 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 761,246
genes like me logo Genes that share compounds with RPL22: view

Transcripts for RPL22 Gene

Unigene Clusters for RPL22 Gene

Ribosomal protein L22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL22 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP2: -

Relevant External Links for RPL22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL22 Gene

mRNA expression in normal human tissues for RPL22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL22 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL22 Gene

SOURCE GeneReport for Unigene cluster for RPL22 Gene Hs.515329

genes like me logo Genes that share expression patterns with RPL22: view

Protein tissue co-expression partners for RPL22 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL22 Gene

Orthologs for RPL22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL22 35
  • 89.32 (n)
  • 99.22 (a)
RPL22 36
  • 75 (a)
(Canis familiaris)
Mammalia RPL22 35
  • 92.19 (n)
  • 99.22 (a)
RPL22 36
  • 82 (a)
(Mus musculus)
Mammalia Rpl22 35
  • 89.06 (n)
  • 99.22 (a)
Rpl22 16
Rpl22 36
  • 98 (a)
(Pan troglodytes)
Mammalia RPL22 35
  • 100 (n)
  • 100 (a)
RPL22 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rpl22 35
  • 89.84 (n)
  • 98.44 (a)
(Monodelphis domestica)
Mammalia RPL22 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia RPL22 36
  • 98 (a)
(Gallus gallus)
Aves RPL22 35
  • 81.79 (n)
  • 97.48 (a)
RPL22 36
  • 95 (a)
(Anolis carolinensis)
Reptilia RPL22 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1774 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9675 35
(Danio rerio)
Actinopterygii rpl22 36
  • 86 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005046 35
  • 64.58 (n)
  • 66.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL22 35
  • 62.54 (n)
  • 68.04 (a)
RpL22 36
  • 26 (a)
RpL22-like 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea rpl-22 35
  • 60.54 (n)
  • 64.29 (a)
rpl-22 36
  • 56 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR221W 35
  • 51.04 (n)
  • 47.92 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D05181g 35
  • 52.43 (n)
  • 48.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL22A 35
  • 50 (n)
  • 47.92 (a)
RPL22A 36
  • 47 (a)
RPL22B 36
  • 43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G05560 35
  • 65.65 (n)
  • 69.39 (a)
(Oryza sativa)
Liliopsida Os03g0343500 35
  • 64.97 (n)
  • 68.37 (a)
(Zea mays)
Liliopsida Zm.4212 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14794 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06661 35
  • 50.17 (n)
  • 47.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl22 35
  • 57.04 (n)
  • 55.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4506 36
  • 70 (a)
CSA.5709 36
  • 71 (a)
Species with no ortholog for RPL22:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL22 Gene

Gene Tree for RPL22 (if available)
Gene Tree for RPL22 (if available)

Paralogs for RPL22 Gene

Paralogs for RPL22 Gene

genes like me logo Genes that share paralogs with RPL22: view

Variants for RPL22 Gene

Sequence variations from dbSNP and Humsavar for RPL22 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3581 -- 6,185,251(+) AAGTA(A/G)AATTT utr-variant-3-prime
rs10260 -- 6,185,755(-) TGCAG(A/T)GGCTA utr-variant-3-prime
rs15593 -- 6,185,231(+) CATGG(G/T)AACAT utr-variant-3-prime
rs1052013 -- 6,186,311(-) TACAA(A/G)TGGGC utr-variant-3-prime
rs1052014 -- 6,186,282(-) GAAAA(C/T)GCGAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL22 Gene

Variant ID Type Subtype PubMed ID
nsv871082 CNV Loss 21882294
nsv871698 CNV Loss 21882294
nsv871817 CNV Loss 21882294
nsv870945 CNV Loss 21882294
dgv119n71 CNV Loss 21882294
nsv831425 CNV Loss 17160897
nsv871123 CNV Loss 21882294
dgv120n71 CNV Loss 21882294
dgv121n71 CNV Loss 21882294

Variation tolerance for RPL22 Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPL22 Gene

Disorders for RPL22 Gene

Relevant External Links for RPL22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL22 Gene

Publications for RPL22 Gene

  1. A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22. (PMID: 8135813) Fujita Y. … Whitney R.G. (Biochem. Biophys. Res. Commun. 1994) 3 4 23 67
  2. Multiple domains of EBER 1, an Epstein-Barr virus noncoding RNA, recruit human ribosomal protein L22. (PMID: 16556938) Fok V. … Steitz J.A. (RNA 2006) 3 23
  3. An acidic amino acid cluster regulates the nucleolar localization and ribosome assembly of human ribosomal protein L22. (PMID: 11056215) Shu-Nu C. … Lin A. (FEBS Lett. 2000) 3 23
  4. EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs). (PMID: 1846807) Toczyski D.P.W. … Steitz J.A. (EMBO J. 1991) 3 23
  5. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3

Products for RPL22 Gene

Sources for RPL22 Gene