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Aliases for RPL22 Gene

Aliases for RPL22 Gene

  • Ribosomal Protein L22 2 3
  • EAP 3 4 6
  • Epstein-Barr Virus Small RNA-Associated Protein 3 4
  • Heparin-Binding Protein HBp15 3 4
  • EBER-Associated Protein 3 4
  • Epstein-Barr-Encoded RNA-Associated Protein 3
  • Heparin-Binding Protein 15 3
  • 60S Ribosomal Protein L22 3
  • HBP15/L22 3
  • HBP15 3
  • L22 3

External Ids for RPL22 Gene

Previous GeneCards Identifiers for RPL22 Gene

  • GC01M005823
  • GC01M006053
  • GC01M005956
  • GC01M005955
  • GC01M005393

Summaries for RPL22 Gene

Entrez Gene Summary for RPL22 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL22 Gene

RPL22 (Ribosomal Protein L22) is a Protein Coding gene. Diseases associated with RPL22 include lymphoepithelioma-like carcinoma and myelodysplastic syndrome. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and heparin binding. An important paralog of this gene is RPL22L1.

Gene Wiki entry for RPL22 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL22 Gene

Genomics for RPL22 Gene

Regulatory Elements for RPL22 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPL22 Gene

6,181,269 bp from pter
6,209,389 bp from pter
28,121 bases
Minus strand

Genomic View for RPL22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL22 Gene

Proteins for RPL22 Gene

  • Protein details for RPL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L22
    Protein Accession:
    Secondary Accessions:
    • B2R495
    • Q6IBD1

    Protein attributes for RPL22 Gene

    128 amino acids
    Molecular mass:
    14787 Da
    Quaternary structure:
    No Data Available
    • Binds to Epstein-Barr virus small RNAs and to heparin

    Three dimensional structures from OCA and Proteopedia for RPL22 Gene

neXtProt entry for RPL22 Gene

Proteomics data for RPL22 Gene at MOPED

Post-translational modifications for RPL22 Gene

  • Ubiquitination at Lys48, Lys52, Lys69, and Lys107
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL22 Gene

No data available for DME Specific Peptides for RPL22 Gene

Domains for RPL22 Gene

Gene Families for RPL22 Gene

  • RPL :L ribosomal proteins

Protein Domains for RPL22 Gene


Suggested Antigen Peptide Sequences for RPL22 Gene

Graphical View of Domain Structure for InterPro Entry



  • P35268
  • Belongs to the ribosomal protein L22e family.
genes like me logo Genes that share domains with RPL22: view

Function for RPL22 Gene

Molecular function for RPL22 Gene

GENATLAS Biochemistry:
60S ribosomal protein L22,14kDa

Gene Ontology (GO) - Molecular Function for RPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8135813
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 22720776
GO:0008201 heparin binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL22: view
genes like me logo Genes that share phenotypes with RPL22: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL22

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL22 Gene

Localization for RPL22 Gene

Subcellular locations from

Jensen Localization Image for RPL22 Gene COMPARTMENTS Subcellular localization image for RPL22 gene
Compartment Confidence
cytosol 5
chloroplast 2
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 22720776
GO:0005737 cytoplasm IDA 8135813
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with RPL22: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL22 Gene

Pathways for RPL22 Gene

genes like me logo Genes that share pathways with RPL22: view

Pathways by source for RPL22 Gene

1 KEGG pathway for RPL22 Gene
1 GeneGo (Thomson Reuters) pathway for RPL22 Gene

Gene Ontology (GO) - Biological Process for RPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL22: view

Compounds for RPL22 Gene

(1) HMDB Compounds for RPL22 Gene

Compound Synonyms Cas Number PubMed IDs
  • Arteven

(2) Novoseek inferred chemical compound relationships for RPL22 Gene

Compound -log(P) Hits PubMed IDs
pristinamycin 73.4 3
azithromycin 40.2 1
genes like me logo Genes that share compounds with RPL22: view

Transcripts for RPL22 Gene

Unigene Clusters for RPL22 Gene

Ribosomal protein L22:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL22

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL22 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP2: -

Relevant External Links for RPL22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL22 Gene

mRNA expression in normal human tissues for RPL22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RPL22 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL22 Gene

SOURCE GeneReport for Unigene cluster for RPL22 Gene Hs.515329

genes like me logo Genes that share expressions with RPL22: view

Expression partners for RPL22 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL22 Gene

Orthologs for RPL22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL22 35
  • 89.32 (n)
  • 99.22 (a)
RPL22 36
  • 75 (a)
(Canis familiaris)
Mammalia RPL22 35
  • 92.19 (n)
  • 99.22 (a)
RPL22 36
  • 82 (a)
(Mus musculus)
Mammalia Rpl22 35
  • 89.06 (n)
  • 99.22 (a)
Rpl22 16
Rpl22 36
  • 98 (a)
(Pan troglodytes)
Mammalia RPL22 35
  • 100 (n)
  • 100 (a)
RPL22 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rpl22 35
  • 89.84 (n)
  • 98.44 (a)
(Monodelphis domestica)
Mammalia RPL22 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia RPL22 36
  • 98 (a)
(Gallus gallus)
Aves RPL22 35
  • 81.79 (n)
  • 97.48 (a)
RPL22 36
  • 95 (a)
(Anolis carolinensis)
Reptilia RPL22 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1774 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9675 35
(Danio rerio)
Actinopterygii rpl22 36
  • 86 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005046 35
  • 64.58 (n)
  • 66.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL22 35
  • 62.54 (n)
  • 68.04 (a)
RpL22 36
  • 26 (a)
RpL22-like 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea rpl-22 35
  • 60.54 (n)
  • 64.29 (a)
rpl-22 36
  • 56 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR221W 35
  • 51.04 (n)
  • 47.92 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D05181g 35
  • 52.43 (n)
  • 48.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL22A 35
  • 50 (n)
  • 47.92 (a)
RPL22A 36
  • 47 (a)
RPL22B 36
  • 43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G05560 35
  • 65.65 (n)
  • 69.39 (a)
(Oryza sativa)
Liliopsida Os03g0343500 35
  • 64.97 (n)
  • 68.37 (a)
(Zea mays)
Liliopsida Zm.4212 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14794 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06661 35
  • 50.17 (n)
  • 47.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl22 35
  • 57.04 (n)
  • 55.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4506 36
  • 70 (a)
CSA.5709 36
  • 71 (a)
Species with no ortholog for RPL22:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL22 Gene

Gene Tree for RPL22 (if available)
Gene Tree for RPL22 (if available)

Paralogs for RPL22 Gene

Paralogs for RPL22 Gene

Selected SIMAP similar genes for RPL22 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with RPL22: view

Variants for RPL22 Gene

Sequence variations from dbSNP and Humsavar for RPL22 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3581 -- 6,185,251(+) AAGTA(A/G)AATTT utr-variant-3-prime
rs10260 -- 6,185,755(-) TGCAG(A/T)GGCTA utr-variant-3-prime
rs15593 -- 6,185,231(+) CATGG(G/T)AACAT utr-variant-3-prime
rs1052014 -- 6,186,282(-) GAAAA(C/T)GCGAC utr-variant-3-prime
rs1053194 -- 6,186,270(-) TCTTT(C/T)TAAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL22 Gene

Variant ID Type Subtype PubMed ID
nsv871082 CNV Loss 21882294
nsv871698 CNV Loss 21882294
nsv871817 CNV Loss 21882294
nsv870945 CNV Loss 21882294
dgv119n71 CNV Loss 21882294
nsv831425 CNV Loss 17160897
nsv871123 CNV Loss 21882294
dgv120n71 CNV Loss 21882294
dgv121n71 CNV Loss 21882294

Relevant External Links for RPL22 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL22 Gene

Disorders for RPL22 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RPL22 Gene in MalaCards »

(3) Diseases for RPL22 Gene including...

genes like me logo Genes that share disorders with RPL22: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RPL22 Gene

Publications for RPL22 Gene

  1. EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs). (PMID: 1846807) Toczyski D.P.W. … Steitz J.A. (EMBO J. 1991) 3 4 23
  2. A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22. (PMID: 8135813) Fujita Y. … Whitney R.G. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  3. An acidic amino acid cluster regulates the nucleolar localization and ribosome assembly of human ribosomal protein L22. (PMID: 11056215) Shu-Nu C. … Lin A. (FEBS Lett. 2000) 3 23
  4. Multiple domains of EBER 1, an Epstein-Barr virus noncoding RNA, recruit human ribosomal protein L22. (PMID: 16556938) Fok V. … Steitz J.A. (RNA 2006) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RPL22 Gene

Sources for RPL22 Gene

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