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RPL22 Gene

protein-coding   GIFtS: 62
GCID: GC01M006179

Ribosomal Protein L22

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein L221 2     HBP152
EAP2 3 5     HBP15/L222
Heparin-Binding Protein HBp152 3     L222
EBER-Associated Protein2 3     Epstein-Barr-Encoded RNA-Associated Protein2
Epstein-Barr Virus Small RNA-Associated Protein2 3     Heparin-Binding Protein 152
60S Ribosomal Protein L222     

External Ids:    HGNC: 103151   Entrez Gene: 61462   Ensembl: ENSG000001162517   OMIM: 1804745   UniProtKB: P352683   

Export aliases for RPL22 gene to outside databases

Previous GC identifers: GC01M005823 GC01M006053 GC01M005956 GC01M005955 GC01M005393


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL22 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the
L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein
can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be
capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for
genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the
genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid
leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21
translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and
this gene actually maps to 1p36.3-p36.2. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPL22 Gene:
RPL22 (ribosomal protein L22) is a protein-coding gene. Diseases associated with RPL22 include hypervitaminosis a, and lymphoepithelioma-like carcinoma. GO annotations related to this gene include heparin binding and RNA binding. An important paralog of this gene is RPL22L1.

Gene Wiki entry for RPL22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL22 gene promoter:
         ER-alpha   GR   p53   GR-beta   Egr-1   Pax-2   MIF-1   Pax-2a   Egr-4   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL22 promoter sequence
   Search Chromatin IP Primers for RPL22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.31   Ensembl cytogenetic band:  1p36.31   HGNC cytogenetic band: 1p36.31

RPL22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL22 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M006179:  view genomic region     (about GC identifiers)

Start:
6,241,329 bp from pter      End:
6,269,449 bp from pter
Size:
28,121 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RL22_HUMAN, P35268 (See protein sequence)
Recommended Name: 60S ribosomal protein L22  
Size: 128 amino acids; 14787 Da
Miscellaneous: Binds to Epstein-Barr virus small RNAs and to heparin
1 PDB 3D structure from and Proteopedia for RPL22:
3J3B (3D)    
Secondary accessions: B2R495 Q6IBD1

Explore the universe of human proteins at neXtProt for RPL22: NX_P35268

Explore proteomics data for RPL22 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys48, Lys52, Lys69, Lys107
  • Modification sites at PhosphoSitePlus

  • See RPL22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000974.1  
    ENSEMBL proteins: 
     ENSP00000465763   ENSP00000346088   ENSP00000468274   ENSP00000466502   ENSP00000466013  
     ENSP00000467247   ENSP00000465313  
    Reactome Protein details: P35268

    RPL22 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for RPL22


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    1 InterPro protein domain:
     IPR002671 Ribosomal_L22e

    Graphical View of Domain Structure for InterPro Entry P35268

    ProtoNet protein and cluster: P35268

    1 Blocks protein domain: IPB002671 Ribosomal L22e protein

    UniProtKB/Swiss-Prot: RL22_HUMAN, P35268
    Similarity: Belongs to the ribosomal protein L22e family


    RPL22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPL22:
    60S ribosomal protein L22,14kDa

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS8135813
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0008201heparin binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    RPL22 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Rpl22):
     cellular  growth/size/body  hematopoietic system  immune system  normal 
     renal/urinary system 

    RPL22 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL22
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPL22
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPL22

    miRNA
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    miRTarBase miRNAs that target RPL22:
    hsa-mir-877-3p (MIRT037108), hsa-mir-23b-3p (MIRT046351), hsa-mir-92a-3p (MIRT049788), hsa-mir-193b-3p (MIRT041525), hsa-mir-197-3p (MIRT048146)

    Block miRNA regulation of human, mouse, rat RPL22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPL22 (see all 18):
    hsa-miR-1287 hsa-miR-3678-3p hsa-miR-448 hsa-miR-300 hsa-miR-509-5p hsa-miR-4272 hsa-miR-218-1* hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidRPL22 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RPL22
    Predesigned siRNA for gene silencing in human, mouse, rat RPL22

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: RPL22 (NM_000983)
    Sino Biological Human cDNA Clone for RPL22
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL22

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RPL22 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    chloroplast2
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA8135813
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325

    RPL22 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPL22 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL22
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL22
        Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPL22 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL22):
        Ribosome


    RPL22 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL22
    Interactions:

        Search GeneGlobe Interaction Network for RPL22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL22 (P352682, 3 ENSP000003460884) via UniProtKB, MINT, STRING, and/or I2D (see all 1093)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSE1LP550602, 3MINT-7945693 MINT-7947479 MINT-63688 I2D: score=5 
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000349960
    UBA5Q9GZZ92, 3MINT-7945693 MINT-7947479 I2D: score=1 
    MAP3K14Q995582, 3MINT-48867 I2D: score=2 
    SHC1P293532, 3MINT-7947479 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPL22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL22 (RL22)

    1 HMDB Compound for RPL22    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    2 Novoseek inferred chemical compound relationships for RPL22 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pristinamycin 73.4 3 17434877 (2), 15190021 (1)
    azithromycin 40.2 1 17110371 (1)



    RPL22 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPL22 gene: 
    NM_000983.3  

    Unigene Clusters for RPL22:

    Ribosomal protein L22
    Hs.515329  [show with all ESTs], Hs.554762  [show with all ESTs]
    Unigene Representative Sequences: NM_000983, BM925427
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484532 ENST00000234875(uc001amd.3 uc001ame.3) ENST00000480661
    ENST00000497965 ENST00000471204 ENST00000465387 ENST00000462296 ENST00000465335

    miRNA
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    Block miRNA regulation of human, mouse, rat RPL22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPL22 (see all 18):
    hsa-miR-1287 hsa-miR-3678-3p hsa-miR-448 hsa-miR-300 hsa-miR-509-5p hsa-miR-4272 hsa-miR-218-1* hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidRPL22 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RPL22
    Predesigned siRNA for gene silencing in human, mouse, rat RPL22
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    GenScript: all cDNA clones in your preferred vector: RPL22 (NM_000983)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL22
    Primer
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    OriGene qPCR primer pairs and template standards for RPL22
    OriGene qSTAR qPCR primer pairs in human, mouse for RPL22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPL22
      QuantiTect SYBR Green Assays in human, mouse, rat RPL22
      QuantiFast Probe-based Assays in human, mouse, rat RPL22

    Additional mRNA sequence: CR456873.1 

    Selected DOTS entries (see all 66):

    DT.95078366  DT.92465754  DT.86996661  DT.100864501  DT.121366503  DT.121366435  DT.100846678  DT.95078342 
    DT.87017899  DT.100040932  DT.100682186  DT.100651297  DT.100682190  DT.99973266  DT.120761601  DT.121366511 
    DT.100682178  DT.92465743  DT.97856099  DT.100060170  DT.100682180  DT.121366527  DT.40306474  DT.120888126 

    Selected AceView cDNA sequences (see all 1193):

    CB160174 AK126012 CD368006 AF113701 BQ774119 BE765722 BQ674954 CF541249 
    BM850357 BM470657 BG472388 N48023 BM766499 AW205724 BU948212 BU541733 
    BM795029 BM837968 BE250686 CR619731 BQ064459 BM720714 BE908815 BQ212801 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RPL22    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for RPL22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPL22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGCTGCCA
    RPL22 Expression
    About this image


    RPL22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
    RPL22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL22 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.515329 Hs.554762
        Custom PCR Arrays for RPL22
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RPL22
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL22 gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl221 , 5 ribosomal protein L221, 5 89.06(n)1
    99.22(a)1
      4 (83.03 cM)5
    199341  NM_009079.31  NP_033105.11 
     1523257425 
    chicken
    (Gallus gallus)
    Aves RPL221 ribosomal protein L22 81.79(n)
    97.48(a)
      373937  NM_204141.1  NP_989472.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPL226
    ribosomal protein L22
    94(a)
    1 ↔ 1
    GL343833.1(1227-3817)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480169172   -- 77.08(n)    48016917 
    zebrafish
    (Danio rerio)
    Actinopterygii BM533317.12   -- 80.45(n)    BM533317.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL221 Ribosomal protein L22 62.54(n)
    68.04(a)
      31022  NM_057786.4  NP_477134.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-221 rpl-22 60.54(n)
    64.29(a)
      173873  NM_062531.5  NP_494932.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL22A1 RPL22A 50(n)
    47.92(a)
      850750   NP_013162.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G055601 AT3G05560 65.65(n)
    69.39(a)
      819722  NM_111429.4  NP_187207.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g03435001 Os03g0343500 64.97(n)
    68.37(a)
      4332802  NM_001056613.1  NP_001050078.1 


    ENSEMBL Gene Tree for RPL22 (if available)
    TreeFam Gene Tree for RPL22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPL22 gene
    RPL22L12  
    1 SIMAP similar gene for RPL22 using alignment to 10 protein entries:     RL22_HUMAN (see all proteins):
    RPL22L1

    RPL22 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPL22 (see all 26)
    PGOHUM00000238617 PGOHUM00000238857 PGOHUM00000242220 PGOHUM00000239601 PGOHUM00000247864


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPL22 (see all 365)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs780906111,2
    C,F--6244662(+) AATCAC/TGGCTT 1 -- ds50012Minor allele frequency- T:0.05WA NS 256
    rs1857162721,2
    --6244774(+) TGGGCA/GCAGCT 1 -- ds50010--------
    rs20381531,2
    C,H--6244809(-) AGTGTG/CAACTT 1 -- ds500113Minor allele frequency- C:0.37MN NA WA CSA 388
    rs1909621201,2
    --6244837(+) AAACGA/GCATTT 1 -- ds50010--------
    rs108644281,2
    C,H--6244864(+) CCCAGG/ACTCTG 1 -- ds500117Minor allele frequency- A:0.00NS EA NA WA CSA 798
    rs1436288651,2
    C--6244902(+) AGTGAC/TAGCCA 1 -- ds50010--------
    rs1150179201,2
    C,F--6244933(+) CAAAAC/AAGCAC 1 -- ds50012Minor allele frequency- A:0.02WA NS 256
    rs1837494831,2
    --6245050(+) TTCACA/GTGCCA 1 -- ds50010--------
    rs1879843241,2
    --6245051(+) TCACAC/TGCCAG 1 -- ds50010--------
    rs115409411,2
    C--6245143(-) GAACTC/TTTGTA 1 -- ut312Minor allele frequency- T:0.00NA 4

    HapMap Linkage Disequilibrium report for RPL22 (6241329 - 6269449 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for RPL22:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871698CNV Loss21882294
    nsv871082CNV Loss21882294
    dgv121n71CNV Loss21882294
    dgv120n71CNV Loss21882294
    nsv871817CNV Loss21882294
    nsv870945CNV Loss21882294
    nsv831425CNV Loss17160897
    dgv119n71CNV Loss21882294
    nsv871123CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL22
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180474    OMIM disorders: --

    15 diseases for RPL22:    
    About MalaCards
    hypervitaminosis a    lymphoepithelioma-like carcinoma    myelodysplastic syndromes    lymphoid leukemia
    myeloid leukemia    acute myeloid leukemia    leukemia    nasopharyngitis
    influenza    pneumonia    hepatitis c virus    hepatitis c
    hepatitis    breast cancer    malaria


    RPL22 for disorders           About GeneDecksing


    Export disorders for RPL22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPL22 gene, integrated from 10 sources (see all 89):
    (articles sorted by number of sources associating them with RPL22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22. (PubMed id 8135813)1, 2, 9 Fujita Y.... Whitney R.G. (Biochem. Biophys. Res. Commun. 1994)
    2. EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs). (PubMed id 1846807)1, 2, 9 Toczyski D.P.W. and Steitz J.A. (EMBO J. 1991)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. An acidic amino acid cluster regulates the nucleolar localization and ribosome assembly of human ribosomal protein L22. (PubMed id 11056215)1, 9 Shu-Nu C....Lin A. (FEBS Lett. 2000)
    6. Multiple domains of EBER 1, an Epstein-Barr virus noncoding RNA, recruit human ribosomal protein L22. (PubMed id 16556938)1, 9 Fok V....Steitz J.A. (RNA 2006)
    7. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    8. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)
    9. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6146 HGNC: 10315 AceView: RPL22andCHD5 Ensembl:ENSG00000116251 euGenes: HUgn6146
    ECgene: RPL22 Kegg: 6146 H-InvDB: RPL22

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPL22 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPL22 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPL22 gene:
    Search GeneIP for patents involving RPL22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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