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Aliases for RPL22 Gene

Aliases for RPL22 Gene

  • Ribosomal Protein L22 2 3 5
  • Epstein-Barr Virus Small RNA-Associated Protein 3 4
  • Heparin-Binding Protein HBp15 3 4
  • EBER-Associated Protein 3 4
  • EAP 3 4
  • Epstein-Barr-Encoded RNA-Associated Protein 3
  • Heparin-Binding Protein 15 3
  • 60S Ribosomal Protein L22 3
  • HBP15/L22 3
  • HBP15 3
  • L22 3

External Ids for RPL22 Gene

Previous GeneCards Identifiers for RPL22 Gene

  • GC01M005823
  • GC01M006053
  • GC01M005956
  • GC01M005955
  • GC01M005393

Summaries for RPL22 Gene

Entrez Gene Summary for RPL22 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL22 Gene

RPL22 (Ribosomal Protein L22) is a Protein Coding gene. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome. An important paralog of this gene is RPL22L1.

Gene Wiki entry for RPL22 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL22 Gene

Genomics for RPL22 Gene

Regulatory Elements for RPL22 Gene

Enhancers for RPL22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F006598 1.6 FANTOM5 ENCODE 17.6 -392.8 -392823 6.9 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 KLHL21 THAP3 RPL22 HES3 LOC102725193 ZBTB48 PHF13 PIR47122 PIR44711
GH01F006404 1 ENCODE 27.5 -195.4 -195447 0.2 ZFP64 ZNF493 ARID4B FEZF1 ZNF121 GLIS2 ZNF302 ZNF143 KLF7 ZNF548 RPL22 PHF13 ZBTB48 GC01M006398 HES2
GH01F006259 1.5 FANTOM5 Ensembl ENCODE 10.5 -52.6 -52610 4.6 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A BRCA1 GLIS2 KLF7 ZNF263 SP3 GPR153 ICMT LINC00337 RPL22 CHD5 RNF207 LOC102724450 THAP3 GC01P006262 ENSG00000271746
GH01F006553 1.1 ENCODE 13.1 -345.1 -345052 2.9 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 ZNF143 PLEKHG5 RPL22 ZBTB48 NOL9 ENSG00000229519
GH01F006412 1.3 Ensembl ENCODE 10.8 -205.6 -205610 4.3 PKNOX1 MLX ZFP64 ARID4B SIN3A ZNF48 ZNF121 ZNF143 ZNF207 KLF13 ESPN RNF207 ICMT LINC00337 HES3 PLEKHG5 LOC102724450 RPL22 CHD5 ACOT7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL22 on UCSC Golden Path with GeneCards custom track

Promoters for RPL22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPL22 Gene

6,181,269 bp from pter
6,209,389 bp from pter
28,121 bases
Minus strand

Genomic View for RPL22 Gene

Genes around RPL22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL22 Gene

Proteins for RPL22 Gene

  • Protein details for RPL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L22
    Protein Accession:
    Secondary Accessions:
    • B2R495
    • Q6IBD1

    Protein attributes for RPL22 Gene

    128 amino acids
    Molecular mass:
    14787 Da
    Quaternary structure:
    No Data Available
    • Binds to Epstein-Barr virus small RNAs and to heparin.

    Three dimensional structures from OCA and Proteopedia for RPL22 Gene

neXtProt entry for RPL22 Gene

Post-translational modifications for RPL22 Gene

  • Ubiquitination at Lys 52, Lys 69, and Lys 107
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL22 Gene

No data available for DME Specific Peptides for RPL22 Gene

Domains & Families for RPL22 Gene

Gene Families for RPL22 Gene

Protein Domains for RPL22 Gene


Suggested Antigen Peptide Sequences for RPL22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L22e family.
  • Belongs to the ribosomal protein L22e family.
genes like me logo Genes that share domains with RPL22: view

Function for RPL22 Gene

Molecular function for RPL22 Gene

GENATLAS Biochemistry:
60S ribosomal protein L22,14kDa

Gene Ontology (GO) - Molecular Function for RPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8135813
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 11145900
GO:0008201 heparin binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL22: view
genes like me logo Genes that share phenotypes with RPL22: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RPL22

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL22 Gene

Localization for RPL22 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL22 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 22720776
GO:0005737 cytoplasm IDA 8135813
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL22: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL22 Gene

Pathways & Interactions for RPL22 Gene

genes like me logo Genes that share pathways with RPL22: view

Pathways by source for RPL22 Gene

1 KEGG pathway for RPL22 Gene
1 GeneGo (Thomson Reuters) pathway for RPL22 Gene

SIGNOR curated interactions for RPL22 Gene


Gene Ontology (GO) - Biological Process for RPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL22: view

Drugs & Compounds for RPL22 Gene

(3) Drugs for RPL22 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 812,256
genes like me logo Genes that share compounds with RPL22: view

Transcripts for RPL22 Gene

Unigene Clusters for RPL22 Gene

Ribosomal protein L22:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL22 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP2: -

Relevant External Links for RPL22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL22 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL22 Gene

Protein tissue co-expression partners for RPL22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL22 Gene:


SOURCE GeneReport for Unigene cluster for RPL22 Gene:

genes like me logo Genes that share expression patterns with RPL22: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL22 Gene

Orthologs for RPL22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL22 34 35
  • 100 (n)
(Monodelphis domestica)
Mammalia RPL22 35
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia RPL22 35
  • 98 (a)
(Canis familiaris)
Mammalia RPL22 34 35
  • 92.19 (n)
(Rattus norvegicus)
Mammalia Rpl22 34
  • 89.84 (n)
(Bos Taurus)
Mammalia RPL22 34 35
  • 89.32 (n)
(Mus musculus)
Mammalia Rpl22 34 16 35
  • 89.06 (n)
(Gallus gallus)
Aves RPL22 34 35
  • 81.79 (n)
(Anolis carolinensis)
Reptilia RPL22 35
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1774 34
(Danio rerio)
Actinopterygii rpl22 35
  • 86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9675 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005046 34
  • 64.58 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL22 34 35
  • 62.54 (n)
RpL22-like 35
  • 18 (a)
(Caenorhabditis elegans)
Secernentea rpl-22 34 35
  • 60.54 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D05181g 34
  • 52.43 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR221W 34
  • 51.04 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL22A 34 35
  • 50 (n)
RPL22B 35
  • 43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G05560 34
  • 65.65 (n)
(Oryza sativa)
Liliopsida Os03g0343500 34
  • 64.97 (n)
(Zea mays)
Liliopsida Zm.4212 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5709 35
  • 71 (a)
CSA.4506 35
  • 70 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl22 34
  • 57.04 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06661 34
  • 50.17 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14794 34
Species where no ortholog for RPL22 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL22 Gene

Gene Tree for RPL22 (if available)
Gene Tree for RPL22 (if available)

Paralogs for RPL22 Gene

Variants for RPL22 Gene

Sequence variations from dbSNP and Humsavar for RPL22 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10260 -- 6,185,755(-) TGCAG(A/T)GGCTA utr-variant-3-prime
rs1052013 -- 6,186,311(-) TACAA(A/G)TGGGC utr-variant-3-prime
rs1052014 -- 6,186,282(-) GAAAA(C/T)GCGAC utr-variant-3-prime
rs1053194 -- 6,186,270(-) TCTTT(C/T)TAAGA utr-variant-3-prime
rs10864428 -- 6,184,804(+) CCCAG(A/G)CTCTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RPL22 Gene

Variant ID Type Subtype PubMed ID
nsv545236 CNV loss 21841781
nsv831425 CNV loss 17160897
nsv945755 CNV duplication 23825009

Variation tolerance for RPL22 Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL22 Gene

Disorders for RPL22 Gene

Relevant External Links for RPL22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL22 Gene

Publications for RPL22 Gene

  1. A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22. (PMID: 8135813) Fujita Y. … Whitney R.G. (Biochem. Biophys. Res. Commun. 1994) 3 4 22 64
  2. EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs). (PMID: 1846807) Toczyski D.P.W. … Steitz J.A. (EMBO J. 1991) 3 4 22 64
  3. Multiple domains of EBER 1, an Epstein-Barr virus noncoding RNA, recruit human ribosomal protein L22. (PMID: 16556938) Fok V. … Steitz J.A. (RNA 2006) 3 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RPL22 Gene

Sources for RPL22 Gene

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