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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPL22 Gene

protein-coding GIFtS: 61
GCID: GC01M006179

ribosomal protein L22

Explore 13 diseases affiliated with
RPL22 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribosomal Protein L22¹ ²		60S Ribosomal Protein L22²
EAP¹ ² ³ ⁵		HBP15²
L22¹ ²		HBP15/L22²
Heparin-Binding Protein HBp15² ³		Epstein-Barr-Encoded RNA-Associated Protein²
EBER-Associated Protein² ³		Heparin-Binding Protein 15²
Epstein-Barr Virus Small RNA-Associated Protein² ³

External Ids:	HGNC: 10315¹	Entrez Gene: 6146²	Ensembl: ENSG00000116251⁷	OMIM: 180474⁵	UniProtKB: P35268³

Export aliases for RPL22 gene to outside databases

Previous GC identifers: GC01M005823 GC01M006053 GC01M005956 GC01M005955 GC01M005393

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL22:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.

Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene

encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family

of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind

specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of

binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding

ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was

previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene

located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these

fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to

1p36.3-p36.2. (provided by RefSeq, Jul 2008)

Gene Wiki entry for RPL22

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_021937.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPL22 gene promoter:
ER-alpha GR p53 GR-beta Egr-1 Pax-2 MIF-1 Pax-2a Egr-4 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPL22 promoter sequence

Search SABiosciences Chromatin IP Primers for RPL22

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL22

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.31 Ensembl cytogenetic band: 1p36.31 HGNC cytogenetic band: 1p36.31

RPL22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL22 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M006179: view genomic region (about GC identifiers)

Start:	6,241,329 bp from pter	End:	6,269,449 bp from pter
Size:	28,121 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RL22_HUMAN, P35268 (See protein sequence)

Recommended Name: 60S ribosomal protein L22

Size: 128 amino acids; 14787 Da

Miscellaneous: Binds to Epstein-Barr virus small RNAs and to heparin

Secondary accessions: B2R495 Q6IBD1

Explore the universe of human proteins at neXtProt for RPL22: NX_P35268

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P35268

RPL22 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000974.1

ENSEMBL proteins:

ENSP00000465763 ENSP00000346088 ENSP00000468274 ENSP00000466502 ENSP00000466013

ENSP00000467247 ENSP00000465313

Reactome Protein details: P35268
Human Recombinant Protein Products:

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	Uscn Proteins for RPL22

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	8135813
GO:0005829	cytosol	TAS	--
GO:0022625	cytosolic large ribosomal subunit	IDA	12962325
GO:0030529	ribonucleoprotein complex	IDA	18809582

RPL22 for ontologies About GeneDecksing

RPL22 Antibody Products:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPL22 for domains About GeneDecksing

1 InterPro domain/family:

IPR002671 Ribosomal_L22e

Graphical View of Domain Structure for InterPro Entry P35268

ProtoNet protein and cluster: P35268

1 Blocks protein family: IPB002671 Ribosomal L22e protein

UniProtKB/Swiss-Prot: RL22_HUMAN, P35268

Similarity: Belongs to the ribosomal protein L22e family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for RPL22:

60S ribosomal protein L22,14kDa

miRNA Products:		OriGene 3'-UTR Clone: RPL22 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPL22
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate RPL22 (see all 18):
		hsa-miR-1287 hsa-miR-3678-3p hsa-miR-448 hsa-miR-300 hsa-miR-509-5p hsa-miR-4272 hsa-miR-218-1* hsa-miR-4314

		SwitchGear 3'UTR luciferase reporter plasmid: RPL22 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL22 (see all 7) OriGene shRNA RFP: RPL22 Browse OriGene siRNA
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RPL22

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: RPL22 (NM_000983)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RPL22
		Search LifeMap BioReagents cell lines for RPL22

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL22

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0003735	structural constituent of ribosome	NAS	12962325
GO:0008201	heparin binding	IEA	--

RPL22 for ontologies About GeneDecksing

Animal Models:
5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rpl22):

cellular

hematopoietic system

immune system

normal

renal/urinary system

RPL22 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of PB1-F2

8/26 pathways (see all 26)
Viral Protein Synthesis	1.00	Cytoplasmic Ribosomal Proteins	0.86
Viral mRNA Translation	1.00	CFTR translational fidelity (class I mutations)	0.83
Influenza Viral RNA Transcription and Replication	1.00	SMG6 Cleaves mRNA with Premature Termination Codon	0.80
Synthesis of nascent polypeptide containing signal sequence	1.00	L13a-mediated translational silencing of Ceruloplasmin expression	0.79

Metabolism of mRNA

Metabolism of mRNA

1.00

Metabolism of RNA

0.92

Disease

Disease

1.00

Generic Transcription Pathway

Gene Expression

0.46

Asparagine N-linked glycosylation

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for RPL22

CFTR translational fidelity (class I mutations)

1 BioSystems Pathway for RPL22

Cytoplasmic Ribosomal Proteins

5/28 Reactome Pathways for RPL22 (see all 28)

	Nonsense Mediated Decay Independent of the Exon Junction Complex
	Nonsense-Mediated Decay
	Translation
	SRP-dependent cotranslational protein targeting to membrane
	Eukaryotic Translation Initiation

1 Kegg Pathway (Kegg details for RPL22):

Ribosome

RPL22 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RPL22

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/971 Interacting proteins for RPL22 (P35268^{2, 3} ENSP00000346088⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 971)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CSE1L	P55060²^,³	MINT-7945693 MINT-7947479 MINT-63688 I2D: score=5
UBA5	Q9GZZ9²^,³	MINT-7945693 MINT-7947479 I2D: score=1
MAP3K14	Q99558²^,³	MINT-48867 I2D: score=2
SHC1	P29353²^,³	MINT-7947479 I2D: score=2
PRKAG1	P54619²^,³	MINT-7945693 I2D: score=1

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	--
GO:0006412	translation	TAS	--
GO:0006413	translational initiation	TAS	--
GO:0006414	translational elongation	TAS	--
GO:0006415	translational termination	TAS	--

RPL22 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RPL22 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RPL22

1 HMDB Compound for RPL22 About this table

Compound	Synonyms	CAS #	PubMed Ids
Heparin	Arteven (see all 17)	9005-49-6	--

2 Novoseek chemical compound relationships for RPL22 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pristinamycin	73.4	3	17434877 (2), 15190021 (1)
azithromycin	40.2	1	17110371 (1)

Search CenterWatch for drugs/clinical trials and news about RPL22 / RL22

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RPL22 gene:

NM_000983.3

Unigene Clusters for RPL22:

Ribosomal protein L22

Hs.515329 [show with all ESTs], Hs.554762 [show with all ESTs]

Unigene Representative Sequences: NM_000983, BM925427

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000484532 ENST00000234875(uc001amd.3 uc001ame.3) ENST00000480661

ENST00000497965 ENST00000471204 ENST00000465387 ENST00000462296 ENST00000465335

miRNA Products:		OriGene 3'-UTR Clone: RPL22 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPL22
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate RPL22 (see all 18):
		hsa-miR-1287 hsa-miR-3678-3p hsa-miR-448 hsa-miR-300 hsa-miR-509-5p hsa-miR-4272 hsa-miR-218-1* hsa-miR-4314

		SwitchGear 3'UTR luciferase reporter plasmid: RPL22 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: RPL22 (NM_000983)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL22

Additional cDNA sequence: CR456873.1

24/66 DOTS entries (see all 66):

DT.95078366 DT.92465754 DT.86996661 DT.100864501 DT.121366503 DT.121366435 DT.100846678 DT.95078342

DT.87017899 DT.100040932 DT.100682186 DT.100651297 DT.100682190 DT.99973266 DT.120761601 DT.121366511

DT.100682178 DT.92465743 DT.97856099 DT.100060170 DT.100682180 DT.121366527 DT.40306474 DT.120888126

24/1193 AceView cDNA sequences (see all 1193):

AI280189 BQ219570 BU676748 T34452 BM553155 BQ183917 BG389544 BG122711

BM469265 BQ777576 AW952427 T32038 BU069971 AA310356 AU133415 CB160174

AK126012 CD368006 AF113701 BQ774119 BE765722 BQ674954 CF541249 BM850357

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for RPL22 About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b
SP1:
SP2:					-

ECgene alternative splicing isoforms for RPL22

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPL22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGCTGCCA

About this image

RPL22 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RPL22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPL22

SOURCE GeneReport for Unigene clusters: Hs.515329 Hs.554762

SABiosciences Custom PCR Arrays for RPL22

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL22

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL22

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL22 gene from 9/39 species (see all 39) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RPL22¹	ribosomal protein L22	81.77(n) 96.87(a)		373937 NM_204141.1 NP_989472.1
lizard (Anolis carolinensis)	Reptilia	RPL22⁶	--	94(a)	1 ↔ 1	GL343833.1(1227-3740)
African clawed frog (Xenopus laevis)	Amphibia	48016917²	--	77.08(n)		48016917
zebrafish (Danio rerio)	Actinopterygii	BM533317.1²	--	80.45(n)		BM533317.1
fruit fly (Drosophila melanogaster)	Insecta	RpL22¹	Ribosomal protein L22	61.83(n) 63.71(a)		31022 NM_057786.4 NP_477134.1
worm (Caenorhabditis elegans)	Secernentea	rpl-22¹	Protein RPL-22	57.14(n) 57.94(a)		173873 NM_062531.4 NP_494932.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPL22A¹	Rpl22ap	51.59(n) 46.96(a)		850750 NP_013162.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G05560¹	60S ribosomal protein L22-2	66.08(n) 67.26(a)		819722 NM_001084643.1 NP_001078112.1
rice (Oryza sativa)	Liliopsida	Os07g0674200¹	hypothetical protein	64.91(n) 68.42(a)		4344261 NM_001067148.1 NP_001060613.1

ENSEMBL Gene Tree for RPL22 (if available)
TreeFam Gene Tree for RPL22 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RPL22 gene

RPL22L1²

1 SIMAP similar gene for RPL22 using alignment to 10 protein entries: RL22_HUMAN (see all proteins):

RPL22L1

RPL22 for paralogs About GeneDecksing

5/26 Pseudogenes.org Pseudogenes for RPL22 (see all 26)
PGOHUM00000238617 PGOHUM00000238857 PGOHUM00000242220 PGOHUM00000239601 PGOHUM00000247864

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78090611^1,2	C,F,	--	6244662(+)	`AATCAC/TGGCTT`	1	--	ds500¹		2		WA NS	256
rs185716272^1,2		--	6244774(+)	`TGGGCA/GCAGCT`	1	--	ds500¹		0	--	--	--	--
rs2038153^1,2	C,H,	--	6244809(-)	`AGTGTG/CAACTT`	1	--	ds500¹		13		MN NA WA CSA	388
rs190962120^1,2		--	6244837(+)	`AAACGA/GCATTT`	1	--	ds500¹		0	--	--	--	--
rs10864428^1,2	C,H,	--	6244864(+)	`CCCAGG/ACTCTG`	1	--	ds500¹		17		NS EA NA WA CSA	798
rs143628865^1,2		--	6244902(+)	`AGTGAC/TAGCCA`	1	--	ds500¹		0	--	--	--	--
rs115017920^1,2	C,F,	--	6244933(+)	`CAAAAC/AAGCAC`	1	--	ds500¹		2		WA NS	256
rs183749483^1,2		--	6245050(+)	`TTCACA/GTGCCA`	1	--	ds500¹		0	--	--	--	--
rs187984324^1,2		--	6245051(+)	`TCACAC/TGCCAG`	1	--	ds500¹		0	--	--	--	--
rs11540941^1,2	C	--	6245143(-)	`GAACTC/TTTGTA`	1	--	ut3¹		2		NA	4

HapMap Linkage Disequilibrium report for RPL22 (6241329 - 6269449 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RPL22
1 CNV: 4200

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL22

DNA2.0 Custom Variant and Variant Library Synthesis for RPL22

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RPL22 for disorders           About GeneDecksing

OMIM gene information: 180474    OMIM disorders: --

13 diseases for RPL22:    About MalaCards

myeloid leukemia lymphoepithelioma-like carcinoma acute myeloid leukemia myelodysplastic syndrome

leukemia hepatitis c pneumonia lung carcinoma

nasopharyngitis hepatitis carcinoma malaria

lymphoid leukemia

1 disease from the University of Copenhagen DISEASES database for RPL22:

Hypervitaminosis A

Export disorders for RPL22 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RPL22 gene, integrated from 9 sources (see all 76):
(articles sorted by number of sources associating them with RPL22)

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A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22. (PubMed id 8135813)^{1, 2, 9} Fujita Y.... Whitney R.G. (1994)
EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs). (PubMed id 1846807)^{1, 2, 9} Toczyski D.P.W. and Steitz J.A. (1991)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
An acidic amino acid cluster regulates the nucleolar localization and ribosome assembly of human ribosomal protein L22. (PubMed id 11056215)^{1, 9} Shu-Nu C....Lin A. (2000)
Multiple domains of EBER 1, an Epstein-Barr virus noncoding RNA, recruit human ribosomal protein L22. (PubMed id 16556938)^{1, 9} Fok V....Steitz J.A. (2006)
The human EKC/KEOPS complex is recruited to Cullin2 ub iquitin ligases by the human tumour antigen PRAME. (PubMed id 22912744)¹ Costessi A....Stunnenberg H.G. (2012)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
A cohesin-RAD21 interactome. (PubMed id 22145905)¹ Panigrahi A.K....Pati D. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6146	HGNC: 10315	AceView: RPL22andCHD5	Ensembl:ENSG00000116251	euGenes: HUgn6146
ECgene: RPL22	Kegg: 6146	H-InvDB: RPL22

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RPL22	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RPL22	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RPL22 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RPL22 gene:
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RPL22 Gene

ribosomal protein L22

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RPL22 Gene

ribosomal protein L22

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