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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL21 Gene

protein-coding   GIFtS: 60
GCID: GC13P027827

ribosomal protein L21
 Explore 8 diseases affiliated with
RPL21 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RPL21    

Aliases
for RPL21 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribosomal Protein L211 2     MGC1042741
L211 2     MGC1042751
DKFZp686C061011     MGC712521
FLJ274581     60S Ribosomal Protein L212

External Ids:    HGNC: 103131   Entrez Gene: 61442   Ensembl: ENSG000001220267   OMIM: 6036365   UniProtKB: P467783   

Export aliases for RPL21 gene to outside databases

Previous GC identifers: GC10M121019 GC13P021805 GC13P026755 GC13P025623 GC13P026723


Summaries
for RPL21 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPL21:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene
encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of
ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are
multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

Gene Wiki entry for RPL21


Genomic Views
for RPL21 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL21 gene promoter:
         FOXF2   ATF-2   STAT5A   CRE-BP1   Nkx6-1   FOXO4   FOXJ2 (long isoform)   ARP-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPL21 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPL21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.2   Ensembl cytogenetic band:  13q12.2   HGNC cytogenetic band: 13q12.2

RPL21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL21 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P027827:  view genomic region     (about GC identifiers)

Start:
 27,825,446 bp from pter      End:
 27,830,828 bp from pter
Size:
 5,383 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 20,093,689-20,094,256     

Proteins
for RPL21 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RL21_HUMAN, P46778 (See protein sequence)
Recommended Name: 60S ribosomal protein L21  
Size: 160 amino acids; 18565 Da
Secondary accessions: Q16699

Explore the universe of human proteins at neXtProt for RPL21: NX_P46778

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P46778

    • RPL21 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000973.2  
    ENSEMBL proteins: 
     ENSP00000346027   ENSP00000434298   ENSP00000351021   ENSP00000370574   ENSP00000370569  
    Reactome Protein details: P46778
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): RPL21
    OriGene Custom Protein Services for RPL21 
    GenScript Custom Purified and Recombinant Proteins Services for RPL21
    Novus Biologicals RPL21 Proteins
    Novus Biologicals RPL21 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RPL21

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325


    RPL21 for ontologies           About GeneDecksing



    RPL21 Antibody Products: 
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    Uscn Antibodies for RPL21
    ThermoFisher Antibodies for RPL21

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    Uscn ELISAs and CLIAs for RPL21

    Protein Domains /
    Families
    for RPL21 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RPL21 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR018259 Ribosomal_L21e_CS
     IPR008991 Translation_prot_SH3-like
     IPR001147 Ribosomal_L21e

    Graphical View of Domain Structure for InterPro Entry P46778

    ProtoNet protein and cluster: P46778

    1 Blocks protein family: IPB001147 Ribosomal protein L21e

    UniProtKB/Swiss-Prot: RL21_HUMAN, P46778
    Similarity: Belongs to the ribosomal protein L21e family


    Function
    for RPL21 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for RPL21:
    60S ribosomal protein L21,gene or pseudogene

    miRNA
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    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL21 (see all 7)
    OriGene shRNA RFP: RPL21
    OriGene siRNA: RPL21
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL21

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RPL21

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL21 (see all 4)
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    GenScript: all cDNA clones in your preferred vector: RPL21 (NM_000982)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL21 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RPL21
    Search LifeMap BioReagents cell lines for RPL21

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPL21

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS7772601
    GO:0003735structural constituent of ribosome NAS12962325


    RPL21 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for RPL21:
     Decreased cell number, increas  Decreased viability of wild-ty  Nuclear 40S maturation defects  Nucleolar pre-40S maturation d 
     S arrest  Synthetic lethal with imatinib 


    Pathways & Interactions
    for RPL21 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    8/26 pathways (see all 26)
    		Viral Protein Synthesis1.00
    		Cytoplasmic Ribosomal Proteins0.86
    		Viral mRNA Translation1.00
    		CFTR translational fidelity (class I mutations)0.83
    		Influenza Viral RNA Transcription and Replication1.00
    		SMG6 Cleaves mRNA with Premature Termination Codon0.80
    		Synthesis of nascent polypeptide containing signal sequence1.00
    		L13a-mediated translational silencing of Ceruloplasmin expression0.79
    2Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    3Disease
    		Disease1.00
    4Generic Transcription Pathway
    		Gene Expression0.46
    5Asparagine N-linked glycosylation
    		Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL21
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL21 
        Cytoplasmic Ribosomal Proteins

    5/28        Reactome Pathways for RPL21 (see all 28)
        Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Eukaryotic Translation Initiation


    1         Kegg Pathway  (Kegg details for RPL21):
        Ribosome


    RPL21 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/304 Interacting proteins for RPL21 (P467782, 3 ENSP000003460274) via UniProtKB, MINT, STRING, and/or I2D (see all 304)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL11P629132, 3, ENSP000003636764MINT-6542674 MINT-6489539 MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000363676
    RPL26P612542, 3, ENSP000002938424MINT-6542674 MINT-6489539 MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000293842
    RPL6Q028782, 3, ENSP000002027734MINT-6542674 MINT-6489539 MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000202773
    RPS3P233962, 3, ENSP000002785724MINT-6542674 MINT-6489539 MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000278572
    RPL13P263732, 3, ENSP000003078894MINT-6542674 MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000307889
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--


    RPL21 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPL21 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL21
    Search CenterWatch for drugs/clinical trials and news about RPL21 / RL21 

    Transcripts
    for RPL21 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPL21 gene: 
    NM_000982.3  

    Unigene Clusters for RPL21:

    Ribosomal protein L21
    Hs.381123  [show with all ESTs], Hs.535873  [show with all ESTs]
    Unigene Representative Sequences: CD389836, CD246367
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311549(uc001uqz.1 uc001ura.3) ENST00000473558 ENST00000461690
    ENST00000272274 ENST00000319826 ENST00000326092 ENST00000493317 ENST00000466550
    ENST00000483765 ENST00000485756

    miRNA
    Products:             		 OriGene 3'-UTR Clone: RPL21
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPL21
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL21 (see all 7)
    OriGene shRNA RFP: RPL21
    OriGene siRNA: RPL21
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL21
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL21 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL21
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    GenScript: all cDNA clones in your preferred vector: RPL21 (NM_000982)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL21
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL21

    Additional cDNA sequence: BC104478.1 

    24/103 DOTS entries (see all 103):

    DT.91784802  DT.91890387  DT.101987372  DT.91798519  DT.100744803  DT.100866865  DT.91936996  DT.121126677 
    DT.100744842  DT.121228971  DT.100744877  DT.100744811  DT.121229164  DT.95307939  DT.121229231  DT.102839588 
    DT.121265273  DT.102839590  DT.100060316  DT.121270291  DT.92002816  DT.121126665  DT.91983622  DT.91784742 

    24/100 AceView cDNA sequences (see all 100):

    BF971634 W38345 BM694484 BX371211 BM795221 AA411855 BM852454 AI683619 
    BM823304 CR602527 AA181991 CK429402 BE047230 AA155996 H88951 BU731103 
    BQ685878 BE695870 CD177010 BG396765 AA126639 BE612594 BQ961905 BM927538 

    GeneLoc Exon Structure


    Expression
    for RPL21 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCATAATAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RPL21 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RPL21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL21

    SOURCE GeneReport for Unigene clusters: Hs.381123 Hs.535873
        SABiosciences Custom PCR Arrays for RPL21
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL21
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPL21

    Orthologs
    for RPL21 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL21 gene from 10/36 species (see all 36)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rpl211 , 5 ribosomal protein L211, 5 89.17(n)1
    99.37(a)1    		   5 (86.50 cM)5
    199331  NM_019647.61  NP_062621.21 
     1468328905 
    chicken
    (Gallus gallus)    		 Aves RPL211 ribosomal protein L21 85(n)
    94.37(a)    		   418933  XM_001233392.1  XP_001233393.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RPL216
    		 --
    		 94(a)
    		 1 ↔ 1
    		 GL343306.1(1040207-1045766)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CB591291.12   -- 82.66(n)    CB591291.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BQ133074.12   -- 75.86(n)   337764  BQ133074.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG127753 protein biosynthesis structural constituent
    of ribosome less    		 72(a)   40F6   --
    worm
    (Caenorhabditis elegans)    		 Secernentea rpl-213 Ribosomal protein L21 63(a)   III(8201241-8202282)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RPL21A(YBR191W)4
    RPL21B1    		 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein less4
    Rpl21bp1    		 60.93(n)1
    59.87(a)1    		   2(606270-607140)4
    8560261  NP_015246.11  8524894 
     NP_009750.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G095906
    AT1G096906
    (see all 4)    		 60S ribosomal protein L21-1
    (see all 4)    		 45(a)
    45(a)
    (see all 4)    		 many → 1
    many → 1
    (see all 4)    		 1(3106502-3107772)
    1(3136188-3137475)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 60S ribosomal protein L21-2, putative, expressed
    		 46(a)
    46(a)
    		 many → 1
    many → 1
    		 10(17113303-17114532)
    3(2263922-2265926)


    ENSEMBL Gene Tree for RPL21 (if available)
    TreeFam Gene Tree for RPL21 (if available) 

    Paralogs
    for RPL21 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL21 gene
    1 SIMAP similar gene for RPL21 using alignment to 5 protein entries:     RL21_HUMAN (see all proteins):
    LOC393079

    RPL21 for paralogs           About GeneDecksing


    5/143 Pseudogenes.org Pseudogenes for RPL21 (see all 143)
    PGOHUM00000257783 PGOHUM00000238669 PGOHUM00000238755 PGOHUM00000238786 PGOHUM00000238822


    Genomic Variants
    for RPL21 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/173 NCBI SNPs in RPL21 are shown (see all 173)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1379186511,2
    		--27823724(+) GTGGCA/GGGCGC 1 -- us2k10--------
    rs1450627831,2
    		C,--27823782(+) GAACCC/TGGGAG 1 -- us2k11Minor allele frequency- T:0.01NS 148
    rs1439524701,2
    		--27823810(+) TCGATA/GTCGCG 1 -- us2k10--------
    rs1403609031,2
    		--27823840(+) GCAACA/CAGAAC 1 -- us2k10--------
    rs1508613481,2
    		C,--27823858(+) CTCTC-/AAA   
       GAAAG    AAAGA     		1 -- us2k10--------
    rs1388514241,2
    		F--27823874(+) GAAAG-/AAA   
       GAAAG    TAATG     		1 -- us2k11Minor allele frequency- AAAGAAAG:0.01NS 148
    rs740410791,2
    		C,--27823923(+) AGTGAC/TTGTAA 1 -- us2k13Minor allele frequency- T:0.05WA NS 268
    rs758037781,2
    		C--27824006(+) GGAGTA/CAACGT 1 -- us2k10--------
    rs1462909831,2
    		C,--27824010(+) TCAACG/ATATTG 1 -- us2k11Minor allele frequency- A:0.01NS 148
    rs740410801,2
    		C,--27824013(+) ACGTAT/CTGAAG 1 -- us2k13Minor allele frequency- C:0.05WA NS 268

    HapMap Linkage Disequilibrium report for RPL21 (27825446 - 27830828 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RPL21: --
    Human Gene Mutation Database (HGMD): RPL21

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    Disorders / Diseases
    for RPL21 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RPL21 for disorders           About GeneDecksing

    OMIM gene information: 603636    OMIM disorders: --

    UniProtKB/Swiss-Prot: RL21_HUMAN, P46778
  • Note=Defects in RPL21 are a cause of generalized hypotrichosis simplex (HTS). A rare form of non-syndromic
    • hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair
    at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age

    8 diseases for RPL21:    About MalaCards
    diamond-blackfan anemia    treacher collins syndrome    hypotrichosis simplex    hypotrichosis
    cataract    osteosarcoma    anemia    malaria


    Export disorders for RPL21 gene to outside databases

    Publications
    for RPL21 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL21 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with RPL21)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PubMed id 7772601)1, 2, 3, 9 Frigerio J.-M.... Iovanna J.L. (1995)
    2. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2, 9 Odintsova T.I....Karpova G.G. (2003)
    3. Mutation in ribosomal protein L21 underlies hereditary hypotrichosis simplex. (PubMed id 21412954)1, 2 Zhou C.... Zhang J. (2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (2002)
    6. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2 Kenmochi N.... Page D.C. (1998)
    7. A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21. (PubMed id 7951316)1, 2 Albertsen H.M....White R. (1994)
    8. Decreased expression of ribosomal proteins in human age-related cataract. (PubMed id 11773032)1, 9 Zhang W....Kantorow M. (2002)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    External Searches for RPL21 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing RPL21 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6144 HGNC: 10313 AceView: RPL21 Ensembl:ENSG00000122026 euGenes: HUgn6144
    ECgene: RPL21 Kegg: 6144 H-InvDB: RPL21

    Other Databases showing RPL21 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RPL21 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL21 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RPL21 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RPL21 gene:
    Search GeneIP for patents involving RPL21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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