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RPL21 Gene

protein-coding   GIFtS: 65
GCID: GC13P027827

Ribosomal Protein L21

  See RPL21-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein L211 2
60S Ribosomal Protein L211 2
L212

External Ids:    HGNC: 103131   Entrez Gene: 61442   Ensembl: ENSG000001220267   OMIM: 6036365   UniProtKB: P467783   

Export aliases for RPL21 gene to outside databases

Previous GC identifers: GC10M121019 GC13P021805 GC13P026755 GC13P025623 GC13P026723


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL21 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family
of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there
are multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPL21 Gene:
RPL21 (ribosomal protein L21) is a protein-coding gene. Diseases associated with RPL21 include hypotrichosis 12, and hypotrichosis 11. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

Gene Wiki entry for RPL21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL21 gene promoter:
         FOXF2   ATF-2   STAT5A   CRE-BP1   Nkx6-1   FOXO4   FOXJ2 (long isoform)   ARP-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL21 promoter sequence
   Search Chromatin IP Primers for RPL21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.2   Ensembl cytogenetic band:  13q12.2   HGNC cytogenetic band: 13q12.2

RPL21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL21 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P027827:  view genomic region     (about GC identifiers)

Start:
27,825,446 bp from pter      End:
27,830,828 bp from pter
Size:
5,383 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RL21_HUMAN, P46778 (See protein sequence)
Recommended Name: 60S ribosomal protein L21  
Size: 160 amino acids; 18565 Da
1 PDB 3D structure from and Proteopedia for RPL21:
3J3B (3D)    
Secondary accessions: Q16699

Explore the universe of human proteins at neXtProt for RPL21: NX_P46778

Explore proteomics data for RPL21 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys21, Lys43
  • Modification sites at PhosphoSitePlus

  • See RPL21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000973.2  
    ENSEMBL proteins: 
     ENSP00000346027   ENSP00000434298   ENSP00000351021   ENSP00000370574   ENSP00000370569  
     ENSP00000471695   ENSP00000473246  
    Reactome Protein details: P46778

    RPL21 Human Recombinant Protein Products:

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    Novus Biologicals RPL21 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPL21

     
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    antibodies-online proteins for RPL21 (15 products) 

     
    antibodies-online peptides for RPL21

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    antibodies-online antibodies for RPL21 (8 products) 

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    Cloud-Clone Corp. ELISAs for RPL21
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    Search eBioscience for ELISAs for RPL21 
    antibodies-online kits for RPL21 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    3 InterPro protein domains:
     IPR018259 Ribosomal_L21e_CS
     IPR008991 Translation_prot_SH3-like
     IPR001147 Ribosomal_L21e

    Graphical View of Domain Structure for InterPro Entry P46778

    ProtoNet protein and cluster: P46778

    1 Blocks protein domain: IPB001147 Ribosomal protein L21e

    UniProtKB/Swiss-Prot: RL21_HUMAN, P46778
    Similarity: Belongs to the ribosomal protein L21e family


    Find genes that share domains with RPL21           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPL21:
    60S ribosomal protein L21,gene or pseudogene

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS7772601
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RPL21           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for RPL21:
     Decreased cell number, increas  Decreased viability of wild-ty  Nuclear 40S maturation defects  Nucleolar pre-40S maturation d 
     S arrest  Synthetic lethal with imatinib 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RPL21

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPL21:
    hsa-mir-16-5p (MIRT031954), hsa-mir-106b-5p (MIRT044294), hsa-mir-128-3p (MIRT045855), hsa-mir-484 (MIRT042180), hsa-mir-652-3p (MIRT039492), hsa-mir-221-3p (MIRT046903), hsa-mir-615-3p (MIRT040024), hsa-mir-17-5p (MIRT050909), hsa-mir-100-5p (MIRT048563), hsa-mir-20a-5p (MIRT050593)

    Block miRNA regulation of human, mouse, rat RPL21 using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat RPL21

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    GenScript: all cDNA clones in your preferred vector: RPL21 (NM_000982)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL21

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RPL21 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    chloroplast2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----

    Find genes that share ontologies with RPL21           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPL21 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease


    Find genes that share SuperPaths with RPL21           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL21
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL21
        Cytoplasmic Ribosomal Proteins

    Selected Reactome Pathways for RPL21 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL21):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL21
    Interactions:

        Search GeneGlobe Interaction Network for RPL21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL21 (P467782, 3 ENSP000003460274) via UniProtKB, MINT, STRING, and/or I2D (see all 390)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL11P629132, 3, ENSP000003636764MINT-6542674 MINT-6489539 MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000363676
    RPL26P612542, 3, ENSP000002938424MINT-6542674 MINT-6489539 MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000293842
    RPS2P158802, 3, ENSP000003418854MINT-6542674 MINT-6489539 MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000341885
    RPS3P233962, 3, ENSP000002785724MINT-6542674 MINT-6489539 MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000278572
    RPL12P300502, 3, ENSP000003547394MINT-6542674 MINT-6489539 MINT-6488791 I2D: score=1 STRING: ENSP00000354739
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    Find genes that share ontologies with RPL21           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL21 (RL21)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPL21 gene: 
    NM_000982.3  

    Unigene Clusters for RPL21:

    Ribosomal protein L21
    Hs.381123  [show with all ESTs], Hs.535873  [show with all ESTs]
    Unigene Representative Sequences: CD389836, CD246367
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311549(uc001uqz.1 uc001ura.3) ENST00000473558 ENST00000461690
    ENST00000272274 ENST00000319826 ENST00000326092 ENST00000493317 ENST00000466550
    ENST00000483765 ENST00000485756
    miRNA
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    GenScript: all cDNA clones in your preferred vector: RPL21 (NM_000982)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL21
    Primer
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    OriGene qPCR primer pairs and template standards for RPL21
    OriGene qSTAR qPCR primer pairs in human, mouse for RPL21
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPL21
      QuantiTect SYBR Green Assays in human, mouse, rat RPL21
      QuantiFast Probe-based Assays in human, mouse, rat RPL21

    Additional mRNA sequence: BC104478.1 

    Selected DOTS entries (see all 103):

    DT.91784802  DT.91890387  DT.101987372  DT.91798519  DT.100744803  DT.100866865  DT.91936996  DT.121126677 
    DT.100744842  DT.121228971  DT.100744877  DT.100744811  DT.121229164  DT.95307939  DT.121229231  DT.102839588 
    DT.121265273  DT.102839590  DT.100060316  DT.121270291  DT.92002816  DT.121126665  DT.91983622  DT.91784742 

    Selected AceView cDNA sequences (see all 100):

    CR602527 BF971634 BE047230 BU731103 BX371211 AA411855 AA155996 BQ685878 
    CK429402 AI683619 BM823304 W38345 BM694484 BM795221 BM852454 H88951 
    AA181991 BG774396 BM423766 AA148052 BG776769 BU732845 BQ720840 BV179622 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPL21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCATAATAGG
    RPL21 Expression
    About this image


    RPL21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             Dental Papilla
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Dermis (Integumentary System)
             Dental Papilla
     
     Tonsil (Hematopoietic System)
    RPL21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL21 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.381123 Hs.535873
        Custom PCR Arrays for RPL21
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RPL21
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL21 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl211 , 5 ribosomal protein L211, 5 89.17(n)1
    99.37(a)1
      5 (86.50 cM)5
    199331  NM_019647.61  NP_062621.21 
     1468328905 
    chicken
    (Gallus gallus)
    Aves RPL211 ribosomal protein L21 85(n)
    94.37(a)
      418933  XM_001233392.2  XP_001233393.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPL216
    ribosomal protein L21
    94(a)
    1 ↔ 1
    GL343306.1(1040195-1045766)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB591291.12   -- 82.66(n)    CB591291.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ133074.12   -- 75.86(n)   337764  BQ133074.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG127753
    RpL211
    protein biosynthesis structural
    constituent of more3
    Ribosomal protein L211
    72(a)3
    67.3(n)1
    72.96(a)1
      40F63
    354531  NM_001273760.11  NP_001260689.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-211 , 3 Ribosomal protein L213
    rpl-211
    63(a)3
    59.79(n)1
    63.75(a)1
      III(8201241-8202282)3
    1761461  NM_066373.51  NP_498774.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL21A(YBR191W)4
    RPL21B1
    Protein component of the large (60S) ribosomal subunit, more4
    RPL21B1
    60.93(n)1
    59.87(a)1
      2(606270-607140)4
    8560261  NP_015246.11  8524894 
     NP_009750.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G095901 AT1G09590 56.26(n)
    48.41(a)
      837486  NM_100831.3  NP_563847.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01410001 Os03g0141000 52.65(n)
    49.04(a)
      9266412  NM_001186331.1  NP_001173260.1 


    ENSEMBL Gene Tree for RPL21 (if available)
    TreeFam Gene Tree for RPL21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPL21 gene
    1 SIMAP similar gene for RPL21 using alignment to 5 protein entries:     RL21_HUMAN (see all proteins):
    LOC393079

    Find genes that share paralogs with RPL21           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RPL21 (see all 143)
    PGOHUM00000257783 PGOHUM00000238669 PGOHUM00000238755 PGOHUM00000238786 PGOHUM00000238822


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPL21 (see all 120)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379186511,2
    --27823724(+) GTGGCA/GGGCGC 1 -- us2k10--------
    rs1450627831,2
    C--27823782(+) GAACCC/TGGGAG 1 -- us2k11Minor allele frequency- T:0.01NS 148
    rs1439524701,2
    --27823810(+) TCGATA/GTCGCG 1 -- us2k10--------
    rs1403609031,2
    C--27823840(+) GCAACA/CAGAAC 1 -- us2k10--------
    rs1388514241,2
    C,F--27823858(+) GAAAG-/AAA   
       GAAAG
    TAATG
    1 -- us2k11Minor allele frequency- AAAGAAAG:0.01NS 148
    rs740410791,2
    C,F--27823923(+) AGTGAC/TTGTAA 1 -- us2k13Minor allele frequency- T:0.05WA NS 268
    rs758037781,2
    C--27824006(+) GGAGTA/CAACGT 1 -- us2k10--------
    rs1462909831,2
    C--27824010(+) TCAACG/ATATTG 1 -- us2k11Minor allele frequency- A:0.01NS 148
    rs740410801,2
    C,F--27824013(+) ACGTAT/CTGAAG 1 -- us2k13Minor allele frequency- C:0.05WA NS 268
    rs1420079001,2
    C--27824141(+) TTACAA/GCTTTC 1 -- us2k11Minor allele frequency- G:0.01NS 148

    HapMap Linkage Disequilibrium report for RPL21 (27825446 - 27830828 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RPL21: --
    Human Gene Mutation Database (HGMD): RPL21
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL21
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603636    OMIM disorders: --

    UniProtKB/Swiss-Prot: RL21_HUMAN, P46778
  • Note=Defects in RPL21 are a cause of generalized hypotrichosis simplex (HTS). A rare form of
    non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals
    typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood
    and progress with age

  • 3 diseases for RPL21:    
    About MalaCards
    hypotrichosis 12    hypotrichosis 11    hypotrichosis simplex

    1 disease from the University of Copenhagen DISEASES database for RPL21:
    Diamond-Blackfan anemia

    Find genes that share disorders with RPL21           About GenesLikeMe

    Genetic Association Database (GAD): RPL21

    Export disorders for RPL21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPL21 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with RPL21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PubMed id 7772601)1, 2, 3, 9 Frigerio J.-M.... Iovanna J.L. (Biochim. Biophys. Acta 1995)
    2. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2, 9 Odintsova T.I....Karpova G.G. (J. Protein Chem. 2003)
    3. Mutation in ribosomal protein L21 underlies hereditary hypotrichosis simplex. (PubMed id 21412954)1, 2 Zhou C.... Zhang J. (Hum. Mutat. 2011)
    4. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)1, 4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    7. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2 Kenmochi N.... Page D.C. (Genome Res. 1998)
    8. A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21. (PubMed id 7951316)1, 2 Albertsen H.M....White R. (Nat. Genet. 1994)
    9. Decreased expression of ribosomal proteins in human age-related cataract. (PubMed id 11773032)1, 9 Zhang W....Kantorow M. (amp 2002)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6144 HGNC: 10313 AceView: RPL21 Ensembl:ENSG00000122026 euGenes: HUgn6144
    ECgene: RPL21 Kegg: 6144 H-InvDB: RPL21

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPL21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RPL21 gene:
    Search GeneIP for patents involving RPL21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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