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Aliases for RPL19 Gene

Aliases for RPL19 Gene

  • Ribosomal Protein L19 2 3 2
  • 60S Ribosomal Protein L19 2 3
  • N-Terminus Truncated 2
  • Cytosolic 2
  • L19 3

External Ids for RPL19 Gene

Summaries for RPL19 Gene

Entrez Gene Summary for RPL19 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL19 Gene

RPL19 (Ribosomal Protein L19) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL19 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL19 Gene

Genomics for RPL19 Gene

Genomic Location for RPL19 Gene

Start:
39,200,283 bp from pter
End:
39,204,727 bp from pter
Size:
4,445 bases
Orientation:
Plus strand

Genomic View for RPL19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL19 Gene

Regulatory Elements for RPL19 Gene

Proteins for RPL19 Gene

  • Protein details for RPL19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84098-RL19_HUMAN
    Recommended name:
    60S ribosomal protein L19
    Protein Accession:
    P84098
    Secondary Accessions:
    • B2R4K2
    • P14118
    • P22908
    • Q502Y6
    • Q7Z6E4

    Protein attributes for RPL19 Gene

    Size:
    196 amino acids
    Molecular mass:
    23466 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD97677.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL19 Gene

neXtProt entry for RPL19 Gene

Proteomics data for RPL19 Gene at MOPED

Post-translational modifications for RPL19 Gene

  • Citrullinated by PADI4.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys21, Lys43, Lys46, Lys92, Lys128, Lys152, Lys153, Lys180, Lys181, and Lys186

Other Protein References for RPL19 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL19 Gene

Domains for RPL19 Gene

Gene Families for RPL19 Gene

HGNC:
  • RPL :L ribosomal proteins

UniProtKB/Swiss-Prot:

RL19_HUMAN
Family:
  • Belongs to the ribosomal protein L19e family.:
    • P84098
genes like me logo Genes that share domains with RPL19: view

Function for RPL19 Gene

Molecular function for RPL19 Gene

GENATLAS Biochemistry: 60S ribosomal protein L19,23kDa

Gene Ontology (GO) - Molecular Function for RPL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 1577483
GO:0003735 structural constituent of ribosome TAS 1577483
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL19: view

Phenotypes for RPL19 Gene

genes like me logo Genes that share phenotypes with RPL19: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL19 Gene

Localization for RPL19 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL19 Gene COMPARTMENTS Subcellular localization image for RPL19 gene
Compartment Confidence
cytosol 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with RPL19: view

Pathways for RPL19 Gene

genes like me logo Genes that share pathways with RPL19: view

Pathways by source for RPL19 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPL19 Gene
1 BioSystems pathway for RPL19 Gene

Gene Ontology (GO) - Biological Process for RPL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS 1577483
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL19: view

Compounds for RPL19 Gene

(3) Drugbank Compounds for RPL19 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
target
ANISOMYCIN
target
PUROMYCIN
target

(2) Novoseek inferred chemical compound relationships for RPL19 Gene

Compound -log(P) Hits PubMed IDs
adp 25.4 1
atp 4.37 1
genes like me logo Genes that share compounds with RPL19: view

Transcripts for RPL19 Gene

Unigene Clusters for RPL19 Gene

Ribosomal protein L19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL19 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1:
SP2: -
SP3:

Relevant External Links for RPL19 Gene

GeneLoc Exon Structure for
RPL19
ECgene alternative splicing isoforms for
RPL19

Expression for RPL19 Gene

mRNA expression in normal human tissues for RPL19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL19 Gene

SOURCE GeneReport for Unigene cluster for RPL19 Gene Hs.381061

genes like me logo Genes that share expressions with RPL19: view

Orthologs for RPL19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL19 36
  • 99.83 (n)
  • 100 (a)
RPL19 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPL19 36
  • 93.37 (n)
  • 100 (a)
RPL19 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL19 36
  • 92.01 (n)
  • 100 (a)
RPL19 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl19 36
  • 92.01 (n)
  • 100 (a)
Rpl19 16
Rpl19 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPL19 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL19 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl19 36
  • 90.99 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPL19 36
  • 84.18 (n)
  • 99.49 (a)
RPL19 37
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL19 37
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl19 36
  • 81.29 (n)
  • 97.45 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.29055 36
rpl19 36
  • 78.06 (n)
  • 93.88 (a)
rpl19 37
  • 94 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004422 36
  • 68.73 (n)
  • 74.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL19 36
  • 70.47 (n)
  • 76.17 (a)
RpL19 37
  • 72 (a)
OneToOne
RpL19 38
  • 74 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-19 36
  • 62.2 (n)
  • 65.98 (a)
rpl-19 37
  • 65 (a)
OneToOne
rpl-19 38
  • 69 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER179C 36
  • 55.91 (n)
  • 57.53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL19A 37
  • 57 (a)
OneToMany
RPL19B 36
  • 54.3 (n)
  • 57.53 (a)
RPL19B 37
  • 57 (a)
OneToMany
RPL19B 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12453g 36
  • 54.3 (n)
  • 57.53 (a)
soybean
(Glycine max)
eudicotyledons Gma.10683 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G02230 36
  • 63.84 (n)
  • 71.19 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3248 36
rice
(Oryza sativa)
Liliopsida Os03g0337800 36
  • 63.4 (n)
  • 64.43 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2739 36
bread mold
(Neurospora crassa)
Ascomycetes NCU05804 36
  • 62.67 (n)
  • 63.02 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl1902 36
  • 56.48 (n)
  • 62.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5596 37
  • 71 (a)
OneToOne
Species with no ortholog for RPL19:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL19 Gene

ENSEMBL:
Gene Tree for RPL19 (if available)
TreeFam:
Gene Tree for RPL19 (if available)

Paralogs for RPL19 Gene

genes like me logo Genes that share paralogs with RPL19: view

No data available for Paralogs for RPL19 Gene

Variants for RPL19 Gene

Sequence variations from dbSNP and Humsavar for RPL19 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs16530 -- 39,200,781(+) TTGGC(C/T)TCTCA intron-variant
rs16538 -- 39,203,864(+) TCCCT(A/G)TATGT intron-variant
rs559502 -- 39,204,808(+) tgtcg(C/T)ccagg downstream-variant-500B
rs2228666 -- 39,202,394(+) GATGC(A/C)GGAAA synonymous-codon, reference
rs3025213 -- 39,202,429(-) AGGCA(C/G)ATGGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RPL19 Gene

Variant ID Type Subtype PubMed ID
nsv833440 CNV Loss 17160897
nsv833441 CNV Loss 17160897
nsv908203 CNV Loss 21882294
nsv908204 CNV Gain 21882294

Relevant External Links for RPL19 Gene

HapMap Linkage Disequilibrium report
RPL19

Disorders for RPL19 Gene

(2) Novoseek inferred disease relationships for RPL19 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 18.8 2
tumors 0 2
genes like me logo Genes that share disorders with RPL19: view

No data available for UniProtKB/Swiss-Prot for RPL19 Gene

Publications for RPL19 Gene

  1. Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19. (PMID: 1598220) Kumabe T. … Yamamoto T. (Nucleic Acids Res. 1992) 3 4 23
  2. High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2. (PMID: 8095182) Henry J.L. … King C.R. (Cancer Res. 1993) 3 4 23
  3. Expression of cholecystokinin in the duodenum of patients with coeliac disease: respective role of atrophy and lymphocytic infiltration. (PMID: 12149109) Deprez P.H. … Geubel A. (Clin. Sci. 2002) 3 23
  4. Ribosomal protein l19 is a prognostic marker for human prostate cancer. (PMID: 16609016) Bee A. … Foster C.S. (Clin. Cancer Res. 2006) 3 23
  5. Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma. (PMID: 19799608) Kuroda K. … Yasumoto K. (Cancer Sci. 2010) 3 23

Products for RPL19 Gene

Sources for RPL19 Gene

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