Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPL18A Gene

Aliases for RPL18A Gene

  • Ribosomal Protein L18a 2 3 5
  • Ribosomal Protein L18a-Like Protein 2 3
  • 60S Ribosomal Protein L18a 2
  • L18A 3

External Ids for RPL18A Gene

Previous GeneCards Identifiers for RPL18A Gene

  • GC12P103772
  • GC19P018362
  • GC19P017815
  • GC19P017831
  • GC19P017970
  • GC19P017536
  • GC19P017964
  • GC19P018175

Summaries for RPL18A Gene

Entrez Gene Summary for RPL18A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]

GeneCards Summary for RPL18A Gene

RPL18A (Ribosomal Protein L18a) is a Protein Coding gene. Diseases associated with RPL18A include hepatitis c virus. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL18A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL18A Gene

Genomics for RPL18A Gene

Regulatory Elements for RPL18A Gene

Promoters for RPL18A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL18A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RPL18A gene promoter:

Genomic Location for RPL18A Gene

Chromosome:
19
Start:
17,859,876 bp from pter
End:
17,864,153 bp from pter
Size:
4,278 bases
Orientation:
Plus strand

Genomic View for RPL18A Gene

Genes around RPL18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL18A Gene

Proteins for RPL18A Gene

  • Protein details for RPL18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02543-RL18A_HUMAN
    Recommended name:
    60S ribosomal protein L18a
    Protein Accession:
    Q02543

    Protein attributes for RPL18A Gene

    Size:
    176 amino acids
    Molecular mass:
    20762 Da
    Quaternary structure:
    • Binds IPO9 with high affinity.
    SequenceCaution:
    • Sequence=CAA56788.1; Type=Frameshift; Positions=65; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL18A Gene

neXtProt entry for RPL18A Gene

Proteomics data for RPL18A Gene at MOPED

Post-translational modifications for RPL18A Gene

  • Ubiquitination at Lys 11, Lys 21, Lys 41, Lys 76, Lys 136, Lys 143, Lys 151, and Lys 170
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL18A Gene

No data available for DME Specific Peptides for RPL18A Gene

Domains & Families for RPL18A Gene

Gene Families for RPL18A Gene

Suggested Antigen Peptide Sequences for RPL18A Gene

Graphical View of Domain Structure for InterPro Entry

Q02543

UniProtKB/Swiss-Prot:

RL18A_HUMAN :
  • Belongs to the ribosomal protein L18Ae family.
Family:
  • Belongs to the ribosomal protein L18Ae family.
genes like me logo Genes that share domains with RPL18A: view

Function for RPL18A Gene

Molecular function for RPL18A Gene

GENATLAS Biochemistry:
60S ribosomal protein L18A

Gene Ontology (GO) - Molecular Function for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with RPL18A: view
genes like me logo Genes that share phenotypes with RPL18A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL18A Gene

Localization for RPL18A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL18A Gene COMPARTMENTS Subcellular localization image for RPL18A gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL18A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL18A Gene

Pathways & Interactions for RPL18A Gene

genes like me logo Genes that share pathways with RPL18A: view

Pathways by source for RPL18A Gene

1 BioSystems pathway for RPL18A Gene
1 KEGG pathway for RPL18A Gene
1 GeneGo (Thomson Reuters) pathway for RPL18A Gene

Gene Ontology (GO) - Biological Process for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL18A: view

No data available for SIGNOR curated interactions for RPL18A Gene

Drugs & Compounds for RPL18A Gene

No Compound Related Data Available

Transcripts for RPL18A Gene

Unigene Clusters for RPL18A Gene

Ribosomal protein L18a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL18A Gene

No ASD Table

Relevant External Links for RPL18A Gene

GeneLoc Exon Structure for
RPL18A
ECgene alternative splicing isoforms for
RPL18A

Expression for RPL18A Gene

mRNA expression in normal human tissues for RPL18A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL18A Gene

This gene is overexpressed in Tlymphocyte (13.8) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL18A Gene



SOURCE GeneReport for Unigene cluster for RPL18A Gene Hs.337766

genes like me logo Genes that share expression patterns with RPL18A: view

Protein tissue co-expression partners for RPL18A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL18A Gene

Orthologs for RPL18A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL18A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL18A 36
  • 100 (a)
OneToOne
RPL18A 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RPL18A 35
  • 91.67 (n)
  • 100 (a)
RPL18A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL18A 36
  • 99 (a)
OneToOne
RPL18A 35
  • 90.91 (n)
  • 99.43 (a)
mouse
(Mus musculus)
Mammalia Rpl18a 36
  • 99 (a)
OneToOne
Rpl18a 35
  • 88.83 (n)
  • 99.43 (a)
Rpl18a 16
oppossum
(Monodelphis domestica)
Mammalia RPL18A 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL18A 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl18a 35
  • 88.83 (n)
  • 99.43 (a)
chicken
(Gallus gallus)
Aves RPL18A 35
  • 81.23 (n)
  • 95.98 (a)
RPL18A 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL18A 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8369 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl18a 35
  • 80.68 (n)
  • 92.61 (a)
Str.18648 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8991 35
zebrafish
(Danio rerio)
Actinopterygii rpl18a 36
  • 91 (a)
OneToOne
rpl18a 35
  • 79.73 (n)
  • 90.91 (a)
zgc56546 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012284 35
  • 66.67 (n)
  • 66.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL18A 37
  • 68 (a)
RpL18A 35
  • 71.59 (n)
  • 68.75 (a)
RpL18A 36
  • 68 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpl-20 37
  • 62 (a)
rpl-20 36
  • 60 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR330C 35
  • 57.79 (n)
  • 56.21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL20A 35
  • 55.75 (n)
  • 56.55 (a)
RPL20A 36
  • 55 (a)
OneToMany
RPL20B 36
  • 55 (a)
OneToMany
RPL20B 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08657g 35
  • 56.55 (n)
  • 59.31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G29965 35
  • 54.9 (n)
  • 53.53 (a)
rice
(Oryza sativa)
Liliopsida Os.24956 35
Os01g0752300 35
  • 58.68 (n)
  • 53.89 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9955 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08389 35
  • 63.94 (n)
  • 60.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2002 35
  • 55.56 (n)
  • 54.97 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15368 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10110 36
  • 62 (a)
OneToOne
Species with no ortholog for RPL18A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL18A Gene

ENSEMBL:
Gene Tree for RPL18A (if available)
TreeFam:
Gene Tree for RPL18A (if available)

Paralogs for RPL18A Gene

genes like me logo Genes that share paralogs with RPL18A: view

No data available for Paralogs for RPL18A Gene

Variants for RPL18A Gene

Sequence variations from dbSNP and Humsavar for RPL18A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17523540 -- 17,859,305(+) CCCCT(C/G)CTCCC upstream-variant-2KB
rs45522337 -- 17,859,992(+) CGGCG(C/T)GGCAG intron-variant
rs71332116 -- 17,858,436(+) GGCGG(C/G)AGAAT upstream-variant-2KB
rs59508068 -- 17,860,311(+) GACGT(A/G)GCGGT intron-variant
rs73518684 -- 17,859,418(+) ATTCA(A/T)TATTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL18A Gene

Variant ID Type Subtype PubMed ID
nsv911209 CNV Loss 21882294
nsv911214 CNV Loss 21882294
nsv911219 CNV Loss 21882294
dgv3766n71 CNV Loss 21882294
nsv911225 CNV Loss 21882294
nsv833772 CNV Gain+Loss 17160897

Variation tolerance for RPL18A Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL18A Gene

HapMap Linkage Disequilibrium report
RPL18A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL18A Gene

Disorders for RPL18A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL18A Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RPL18A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL18A
genes like me logo Genes that share disorders with RPL18A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL18A Gene

Publications for RPL18A Gene

  1. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 67
  2. Human ribosomal protein L18a interacts with hepatitis C virus internal ribosome entry site. (PMID: 16195786) Dhar D. … Das S. (Arch. Virol. 2006) 3 23
  3. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3
  4. The leucine zipper of c-Jun binds to ribosomal protein L18a: a role in Jun protein regulation? (PMID: 7662174) Gramatikoff K. … Georgiev O. (Biol. Chem. Hoppe-Seyler 1995) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for RPL18A Gene

Sources for RPL18A Gene

Back to Top

Content