Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL18A Gene

protein-coding   GIFtS: 60
GCID: GC19P017970

Ribosomal Protein L18a

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein L18a1 2
60S Ribosomal Protein L18a1 2
Ribosomal Protein L18a-Like Protein1 2
L18A2

External Ids:    HGNC: 103111   Entrez Gene: 61422   Ensembl: ENSG000001056407   OMIM: 6041785   UniProtKB: Q025433   

Export aliases for RPL18A gene to outside databases

Previous GC identifers: GC12P103772 GC19P018362 GC19P017815 GC19P017831 GC19P017536


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL18A Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The
encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome
entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is
typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed
throughout the genome. (provided by RefSeq, Jul 2012)

GeneCards Summary for RPL18A Gene: 
RPL18A (ribosomal protein L18a) is a protein-coding gene. Diseases associated with RPL18A include hepatitis c, and hepatitis, and among its related super-pathways are Eukaryotic Translation Initiation and Metabolism of RNA. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

Gene Wiki entry for RPL18A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL18A gene promoter:
         STAT5B   Sp1   AP-1   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL18A promoter sequence
   Search SABiosciences Chromatin IP Primers for RPL18A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL18A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

RPL18A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL18A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017970:  view genomic region     (about GC identifiers)

Start:
17,970,685 bp from pter      End:
17,974,962 bp from pter
Size:
4,278 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RL18A_HUMAN, Q02543 (See protein sequence)
Recommended Name: 60S ribosomal protein L18a  
Size: 176 amino acids; 20762 Da
Subunit: Binds IPO9 with high affinity
Sequence caution: Sequence=CAA56788.1; Type=Frameshift; Positions=65;
1 PDB 3D structure from and Proteopedia for RPL18A:
3J3B (3D)    

Explore the universe of human proteins at neXtProt for RPL18A: NX_Q02543

Explore proteomics data for RPL18A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q02543

  • RPL18A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPL18A Protein Expression
    REFSEQ proteins: NP_000971.1  
    ENSEMBL proteins: 
     ENSP00000222247   ENSP00000471584   ENSP00000471360   ENSP00000473155   ENSP00000471748  
    Reactome Protein details: Q02543
    Human Recombinant Protein Products for RPL18A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RPL18A
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RPL18A
    GenScript Custom Purified and Recombinant Proteins Services for RPL18A
    Novus Biologicals RPL18A Proteins
    Novus Biologicals RPL18A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPL18A 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325

    RPL18A for ontologies           About GeneDecksing



    RPL18A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RPL18A
    GenScript Custom Superior Antibodies Services for RPL18A
    Novus Biologicals RPL18A Antibody
    Abcam antibodies for RPL18A
    Cloud-Clone Corp. Antibodies for RPL18A 
    ThermoFisher Antibody for RPL18A
    LSBio Antibodies in human, mouse, rat for RPL18A 

    Assay Products for RPL18A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RPL18A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RPL18A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RPL18A 
    Cloud-Clone Corp. CLIAs for RPL18A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RPL: L ribosomal proteins

    2 InterPro protein domains:
     IPR021138 Ribosomal_L18a
     IPR023573 Ribosomal_L18a/LX

    Graphical View of Domain Structure for InterPro Entry Q02543

    ProtoNet protein and cluster: Q02543

    1 Blocks protein domain: IPB002670 Ribosomal L18ae protein

    UniProtKB/Swiss-Prot: RL18A_HUMAN, Q02543
    Similarity: Belongs to the ribosomal protein L18Ae family


    RPL18A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for RPL18A:
    60S ribosomal protein L18A

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS9582194
    GO:0003735structural constituent of ribosome NAS12962325
         
    RPL18A for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for RPL18A:
     Decreased cell number, increas  Decreased viability of wild-ty  Nuclear 60S biogenesis defects  Nucleolar pre-40S maturation d 
     S arrest 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPL18A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPL18A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPL18A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPL18A 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPL18A
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RPL18A
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPL18A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL18A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPL18A
    Sirion Biotech Customized adenovirus for overexpression of RPL18A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RPL18A (see all 7)
    OriGene ORF clones in mouse, rat for RPL18A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPL18A (NM_000980)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL18A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL18A
    Sirion Biotech Customized lentivirus for stable overexpression of RPL18A 
                         Customized lentivirus expression plasmids for stable overexpression of RPL18A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RPL18A
    Search LifeMap BioReagents cell lines for RPL18A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL18A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPL18A About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Viral mRNA Translation
    Influenza Life Cycle0.95
    3' -UTR-mediated translational regulation0.93
    Influenza Infection0.95
    L13a-mediated translational silencing of Ceruloplasmin expression0.93
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Formation of a pool of free 40S subunits0.90
    Eukaryotic Translation Termination0.94
    Nonsense-Mediated Decay0.84
    2Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    3Generic Transcription Pathway
    Gene Expression0.47
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL18A
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL18A
        Cytoplasmic Ribosomal Proteins

    5/23        Reactome Pathways for RPL18A (see all 23)
        Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Eukaryotic Translation Initiation


    1         Kegg Pathway  (Kegg details for RPL18A):
        Ribosome


    RPL18A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPL18A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/515 Interacting proteins for RPL18A (Q025431, 2, 3 ENSP000002222474) via UniProtKB, MINT, STRING, and/or I2D (see all 515)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPL18A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL18A (RL18A)

    Search CenterWatch for drugs/clinical trials and news about RPL18A / RL18A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPL18A gene: 
    NM_000980.3  

    Unigene Cluster for RPL18A:

    Ribosomal protein L18a
    Hs.337766  [show with all ESTs]
    Unigene Representative Sequence: BQ050118
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222247(uc002nhp.2) ENST00000600147 ENST00000599898 ENST00000602216
    ENST00000597648 ENST00000599870 ENST00000600238
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPL18A
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RPL18A
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPL18A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL18A
    Clone
    Products:
         
    OriGene clones in human, mouse for RPL18A (see all 7)
    OriGene ORF clones in mouse, rat for RPL18A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPL18A (NM_000980)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL18A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL18A
    Sirion Biotech Customized lentivirus for stable overexpression of RPL18A 
                         Customized lentivirus expression plasmids for stable overexpression of RPL18A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RPL18A
    OriGene qSTAR qPCR primer pairs in human, mouse for RPL18A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPL18A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL18A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL18A

    Additional mRNA sequence: 

    AK222647.1 AK297323.1 AK297358.1 AK300809.1 AK311774.1 AY779046.1 BC007512.2 BC066319.1 
    BC071920.1 L05093.1 X80822.1 

    24/67 DOTS entries (see all 67):

    DT.100729755  DT.91806807  DT.99953477  DT.100729745  DT.100729777  DT.100729776  DT.451333  DT.91968871 
    DT.91856750  DT.100856198  DT.121139960  DT.91668700  DT.91903236  DT.92003336  DT.100729769  DT.121431777 
    DT.91819008  DT.100729748  DT.121432177  DT.100729752  DT.91637683  DT.121432220  DT.121431821  DT.121140092 

    24/2297 AceView cDNA sequences (see all 2297):

    CB108306 CA426047 BU527955 CB148317 N20964 BM686670 H59123 BQ941229 
    H43519 BG107725 BQ434352 AI734943 BG910513 BF724443 T28417 BM767012 
    CR617184 BM462059 AA305880 CR600845 AJ573045 BG756062 BI259292 BU160669 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL18A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGTGGAGG
    RPL18A Expression
    About this image


    See RPL18A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL18A

    SOURCE GeneReport for Unigene cluster: Hs.337766
        SABiosciences Custom PCR Arrays for RPL18A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RPL18A
    OriGene qSTAR qPCR primer pairs in human, mouse for RPL18A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPL18A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL18A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL18A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL18A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL18A gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl18a1 , 5 ribosomal protein L18A1, 5 88.83(n)1
    99.43(a)1
      8 (34.38 cM)5
    768081  NM_029751.41  NP_084027.11 
     708947225 
    chicken
    (Gallus gallus)
    Aves RPL18A1 ribosomal protein L18a 82.16(n)
    97.65(a)
      417823  XM_416064.3  XP_416064.3 
    lizard
    (Anolis carolinensis)
    Reptilia RPL18A6
    60S ribosomal protein L18a
    99(a)
    1 ↔ 1
    5(50519772-50527795)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.83692 Xenopus laevis, Similar to ribosomal protein L18a, more 81.62(n)    BC042256.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565462 similar to 60S ribosomal protein L18a 79.22(n)   394035  BC049045.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL18A1 , 3 protein biosynthesis structural
    constituent of more3
    Ribosomal protein L18A1
    68(a)3
    71.59(n)1
    68.75(a)1
      54C33
    369851  NM_079050.21  NP_523774.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-201 , 3 ribosomal protein3
    Ribosomal Protein, Large subunit1
    62(a)3
    62.48(n)1
    62.86(a)1
      IV(4749375-4749965)3
    35652641  NM_068229.21  NP_500630.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL20B(YOR312C)4
    RPL20A1
    Protein component of the large (60S) ribosomal subunit, more4
    Rpl20ap1
    55.89(n)1
    56.89(a)1
      15(901194-900250)4
    8552831  NP_013969.31  8544894 
     NP_014957.24 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RPL18AA1 60S ribosomal protein L18a-1 55.03(n)
    53.85(a)
      839876  NM_001084157.1  NP_001077626.1 
    rice
    (Oryza sativa)
    Liliopsida Os.249562 Transcribed sequence with weak similarity to protein more 75.44(n)    CA763169.1 


    ENSEMBL Gene Tree for RPL18A (if available)
    TreeFam Gene Tree for RPL18A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL18A gene

    RPL18A for paralogs           About GeneDecksing


    5/20 Pseudogenes.org Pseudogenes for RPL18A (see all 20)
    PGOHUM00000248436 PGOHUM00000247885 PGOHUM00000246917 PGOHUM00000237376 PGOHUM00000237427


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/72 SNPs in RPL18A are shown (see all 72)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426334721,2
    --17968871(+) GATCAC/TGCTGC 1 -- us2k10--------
    rs1817721401,2
    --17968876(+) CGCTGC/TTGCAC 1 -- us2k10--------
    rs1459467651,2
    --17968988(+) GTAACA/GTATTT 1 -- us2k10--------
    rs1118376781,2
    C--17969069(+) CGGTGA/GCTTAC 1 -- us2k10--------
    rs713321161,2
    C,F--17969245(+) GGCGGC/GAGAAT 1 -- us2k12Minor allele frequency- G:0.00NA 4
    rs1868538941,2
    --17969294(+) ATAGCA/GCCACT 1 -- us2k10--------
    rs1116576671,2
    C,F--17969331(+) GACTCG/AGTCTC 1 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs1905481861,2
    --17969355(+) AAAAGA/GAAAGA 1 -- us2k10--------
    rs1827990971,2
    --17969399(+) ACAAAA/GCCAGA 1 -- us2k10--------
    rs1429268211,2
    --17969422(+) GAAATA/GCAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPL18A (17970685 - 17974962 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RPL18A:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3766n71CNV Loss21882294
    nsv911219CNV Loss21882294
    nsv911214CNV Loss21882294
    nsv911225CNV Loss21882294
    nsv911209CNV Loss21882294
    nsv833772CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL18A
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL18A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604178    OMIM disorders: --

    4 diseases for RPL18A:    About MalaCards
    hepatitis c    hepatitis    influenza    breast cancer


    RPL18A for disorders           About GeneDecksing


    Export disorders for RPL18A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL18A gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with RPL18A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    4. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PubMed id 11823430)1, 2 Jaekel S.... Goerlich D. (2002)
    5. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 3 Kenmochi N.... Page D.C. (1998)
    6. Human ribosomal protein L18a interacts with hepatitis C virus internal ribosome entry site. (PubMed id 16195786)1, 9 Dhar D.... Das S. (2006)
    7. The leucine zipper of c-Jun binds to ribosomal protein L18a: a role in Jun protein regulation? (PubMed id 7662174)1, 9 Gramatikoff K....Georgiev O. (1995)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (2013)
    10. The P-body component USP52/PAN2 is a novel regulator o f HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6142 HGNC: 10311 AceView: RPL18A Ensembl:ENSG00000105640 euGenes: HUgn6142
    ECgene: RPL18A Kegg: 6142 H-InvDB: RPL18A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL18A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPL18A gene:
    Search GeneIP for patents involving RPL18A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RPL18A  
     OriGene qPCR primer pairs and template standards for RPL18A   OriGene Protein Over-expression Lysate for RPL18A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RPL18A  
     OriGene qSTAR qPCR primer pairs in human, mouse for RPL18A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RPL18A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPL18A   OriGene Custom Protein Services for RPL18A  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPL18A
     QIAGEN SeqTarget long-range PCR primers for resequencing RPL18A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL18A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL18A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL18A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL18A
     GenScript Custom Purified and Recombinant Proteins Services for RPL18A GenScript cDNA clones with any tag delivered in your preferred vector for RPL18A
     GenScript Custom Assay Services for RPL18A GenScript Custom Superior Antibodies Services for RPL18A
     GenScript Custom overexpressing Cell Line Services for RPL18A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RPL18A promoter
     Search Chromatin IP Primers for RPL18A
     RT2 qPCR Primer Assay in human, mouse, rat RPL18A
     GNC Network for RPL18A
     SABiosciences Custom PCR Arrays for RPL18A
     Search Tocris compounds for RPL18A (RL18A)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RPL18A antibodies
     RPL18A proteins
     RPL18A lysates
     Antibodies for RPL18A
     See all of Abcam's Antibodies, Kits and Proteins for RPL18A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RPL18A
     Antibodies for RPL18A
     ELISAs for RPL18A
     CLIAs for RPL18A
     Search LifeMap BioReagents cell lines for RPL18A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL18A
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RPL18A
     SwitchGear Promoter luciferase reporter plasmids for RPL18A
     ThermoFisher Antibody for RPL18A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL18A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RPL18A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPL18A
    Customized:
     lentivirus for stable overexpression of RPL18A
     lentivirus expression plasmids for stable overexpression of RPL18A
     adenovirus for overexpression of RPL18A
     LSBio Antibodies in human, mouse, rat for RPL18A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RPL18A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4