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Aliases for RPL18A Gene

Aliases for RPL18A Gene

  • Ribosomal Protein L18a 2 3
  • Ribosomal Protein L18a-Like Protein 2 3
  • 60S Ribosomal Protein L18a 2 3
  • L18A 3

External Ids for RPL18A Gene

Previous GeneCards Identifiers for RPL18A Gene

  • GC12P103772
  • GC19P018362
  • GC19P017815
  • GC19P017831
  • GC19P017970
  • GC19P017536

Summaries for RPL18A Gene

Entrez Gene Summary for RPL18A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]

GeneCards Summary for RPL18A Gene

RPL18A (Ribosomal Protein L18a) is a Protein Coding gene. Diseases associated with RPL18A include hepatitis c and hepatitis c virus. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL18A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL18A Gene

Genomics for RPL18A Gene

Regulatory Elements for RPL18A Gene

Transcription factor binding sites by QIAGEN in the RPL18A gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPL18A Gene

17,859,876 bp from pter
17,864,153 bp from pter
4,278 bases
Plus strand

Genomic View for RPL18A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL18A Gene

Proteins for RPL18A Gene

  • Protein details for RPL18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L18a
    Protein Accession:
    Secondary Accessions:

    Protein attributes for RPL18A Gene

    176 amino acids
    Molecular mass:
    20762 Da
    Quaternary structure:
    • Binds IPO9 with high affinity
    • Sequence=CAA56788.1; Type=Frameshift; Positions=65; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL18A Gene

neXtProt entry for RPL18A Gene

Proteomics data for RPL18A Gene at MOPED

Post-translational modifications for RPL18A Gene

  • Ubiquitination at Lys11, Lys21, Lys41, Lys70, Lys76, Lys136, Lys143, Lys151, and Lys170
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL18A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL18A Gene

Domains for RPL18A Gene

Gene Families for RPL18A Gene

  • RPL :L ribosomal proteins

Suggested Antigen Peptide Sequences for RPL18A Gene

Graphical View of Domain Structure for InterPro Entry



  • Q02543
  • Belongs to the ribosomal protein L18Ae family.
genes like me logo Genes that share domains with RPL18A: view

Function for RPL18A Gene

Molecular function for RPL18A Gene

GENATLAS Biochemistry: 60S ribosomal protein L18A

Gene Ontology (GO) - Molecular Function for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9582194
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL18A: view
genes like me logo Genes that share phenotypes with RPL18A: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL18A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL18A Gene

Localization for RPL18A Gene

Subcellular locations from

Jensen Localization Image for RPL18A Gene COMPARTMENTS Subcellular localization image for RPL18A gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
genes like me logo Genes that share ontologies with RPL18A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL18A Gene

Pathways for RPL18A Gene

genes like me logo Genes that share pathways with RPL18A: view

Pathways by source for RPL18A Gene

1 KEGG pathway for RPL18A Gene
1 GeneGo (Thomson Reuters) pathway for RPL18A Gene

Gene Ontology (GO) - Biological Process for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL18A: view

Transcripts for RPL18A Gene

Unigene Clusters for RPL18A Gene

Ribosomal protein L18a:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL18A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL18A Gene

No ASD Table

Relevant External Links for RPL18A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL18A Gene

mRNA expression in normal human tissues for RPL18A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL18A Gene

SOURCE GeneReport for Unigene cluster for RPL18A Gene Hs.337766

genes like me logo Genes that share expressions with RPL18A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL18A Gene

Orthologs for RPL18A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL18A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL18A 35
  • 100 (n)
  • 100 (a)
RPL18A 36
  • 100 (a)
(Bos Taurus)
Mammalia RPL18A 35
  • 91.67 (n)
  • 100 (a)
RPL18A 36
  • 100 (a)
(Canis familiaris)
Mammalia RPL18A 35
  • 90.91 (n)
  • 99.43 (a)
RPL18A 36
  • 99 (a)
(Mus musculus)
Mammalia Rpl18a 35
  • 88.83 (n)
  • 99.43 (a)
Rpl18a 16
Rpl18a 36
  • 99 (a)
(Monodelphis domestica)
Mammalia RPL18A 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia RPL18A 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Rpl18a 35
  • 88.83 (n)
  • 99.43 (a)
(Gallus gallus)
Aves RPL18A 35
  • 81.23 (n)
  • 95.98 (a)
RPL18A 36
  • 93 (a)
(Anolis carolinensis)
Reptilia RPL18A 36
  • 99 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8369 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl18a 35
  • 80.68 (n)
  • 92.61 (a)
Str.18648 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8991 35
(Danio rerio)
Actinopterygii rpl18a 35
  • 79.73 (n)
  • 90.91 (a)
rpl18a 36
  • 91 (a)
zgc56546 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012284 35
  • 66.67 (n)
  • 66.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL18A 35
  • 71.59 (n)
  • 68.75 (a)
RpL18A 36
  • 68 (a)
RpL18A 37
  • 68 (a)
(Caenorhabditis elegans)
Secernentea rpl-20 36
  • 60 (a)
rpl-20 37
  • 62 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR330C 35
  • 57.79 (n)
  • 56.21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL20A 35
  • 55.75 (n)
  • 56.55 (a)
RPL20A 36
  • 55 (a)
RPL20B 36
  • 55 (a)
RPL20B 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08657g 35
  • 56.55 (n)
  • 59.31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G29965 35
  • 54.9 (n)
  • 53.53 (a)
(Oryza sativa)
Liliopsida Os.24956 35
Os01g0752300 35
  • 58.68 (n)
  • 53.89 (a)
(Triticum aestivum)
Liliopsida Ta.9955 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08389 35
  • 63.94 (n)
  • 60.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2002 35
  • 55.56 (n)
  • 54.97 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15368 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10110 36
  • 62 (a)
Species with no ortholog for RPL18A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL18A Gene

Gene Tree for RPL18A (if available)
Gene Tree for RPL18A (if available)

Paralogs for RPL18A Gene

genes like me logo Genes that share paralogs with RPL18A: view

No data available for Paralogs for RPL18A Gene

Variants for RPL18A Gene

Sequence variations from dbSNP and Humsavar for RPL18A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1000262 -- 17,859,818(+) CGGGT(C/G)GCTTT upstream-variant-2KB
rs7508025 -- 17,863,414(+) TTTCT(C/T)TGTCC downstream-variant-500B
rs10406314 -- 17,860,170(+) ACCTG(A/G)GCCAG intron-variant
rs10406737 -- 17,860,350(+) GAATG(G/T)CTGTG intron-variant
rs10407385 -- 17,859,909(+) CGCGA(A/C)AGAGG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL18A Gene

Variant ID Type Subtype PubMed ID
nsv911209 CNV Loss 21882294
nsv911214 CNV Loss 21882294
nsv911219 CNV Loss 21882294
dgv3766n71 CNV Loss 21882294
nsv911225 CNV Loss 21882294
nsv833772 CNV Gain+Loss 17160897

Relevant External Links for RPL18A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL18A Gene

Disorders for RPL18A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for RPL18A Gene including...

Search for RPL18A Gene in MalaCards »
genes like me logo Genes that share disorders with RPL18A: view

No data available for UniProtKB/Swiss-Prot for RPL18A Gene

Publications for RPL18A Gene

  1. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4
  2. The leucine zipper of c-Jun binds to ribosomal protein L18a: a role in Jun protein regulation? (PMID: 7662174) Gramatikoff K. … Georgiev O. (Biol. Chem. Hoppe-Seyler 1995) 3 23
  3. Human ribosomal protein L18a interacts with hepatitis C virus internal ribosome entry site. (PMID: 16195786) Dhar D. … Das S. (Arch. Virol. 2006) 3 23
  4. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3
  5. Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jaekel S. … Goerlich D. (EMBO J. 2002) 3 4

Products for RPL18A Gene

Sources for RPL18A Gene

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