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Aliases for RPL18A Gene

Aliases for RPL18A Gene

  • Ribosomal Protein L18a 2 3 5
  • Ribosomal Protein L18a-Like Protein 2 3
  • 60S Ribosomal Protein L18a 2 3
  • L18A 3

External Ids for RPL18A Gene

Previous GeneCards Identifiers for RPL18A Gene

  • GC12P103772
  • GC19P018362
  • GC19P017815
  • GC19P017831
  • GC19P017970
  • GC19P017536
  • GC19P017964
  • GC19P018175
  • GC19P018293

Summaries for RPL18A Gene

Entrez Gene Summary for RPL18A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]

GeneCards Summary for RPL18A Gene

RPL18A (Ribosomal Protein L18a) is a Protein Coding gene. Diseases associated with RPL18A include Hepatitis C Virus. Among its related pathways are Viral mRNA Translation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL18A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL18A Gene

Genomics for RPL18A Gene

Regulatory Elements for RPL18A Gene

Enhancers for RPL18A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RPL18A on UCSC Golden Path with GeneCards custom track

Promoters for RPL18A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL18A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RPL18A gene promoter:

Genomic Location for RPL18A Gene

Chromosome:
19
Start:
17,859,876 bp from pter
End:
17,864,153 bp from pter
Size:
4,278 bases
Orientation:
Plus strand

Genomic View for RPL18A Gene

Genes around RPL18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL18A Gene

Proteins for RPL18A Gene

  • Protein details for RPL18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02543-RL18A_HUMAN
    Recommended name:
    60S ribosomal protein L18a
    Protein Accession:
    Q02543

    Protein attributes for RPL18A Gene

    Size:
    176 amino acids
    Molecular mass:
    20762 Da
    Quaternary structure:
    • Binds IPO9 with high affinity.
    SequenceCaution:
    • Sequence=CAA56788.1; Type=Frameshift; Positions=65; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL18A Gene

neXtProt entry for RPL18A Gene

Post-translational modifications for RPL18A Gene

  • Ubiquitination at Lys 11, Lys 21, Lys 41, Lys 76, Lys 136, Lys 143, Lys 151, and Lys 170
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL18A Gene

No data available for DME Specific Peptides for RPL18A Gene

Domains & Families for RPL18A Gene

Gene Families for RPL18A Gene

Suggested Antigen Peptide Sequences for RPL18A Gene

Graphical View of Domain Structure for InterPro Entry

Q02543

UniProtKB/Swiss-Prot:

RL18A_HUMAN :
  • Belongs to the ribosomal protein L18Ae family.
Family:
  • Belongs to the ribosomal protein L18Ae family.
genes like me logo Genes that share domains with RPL18A: view

Function for RPL18A Gene

Molecular function for RPL18A Gene

GENATLAS Biochemistry:
60S ribosomal protein L18A

Gene Ontology (GO) - Molecular Function for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9582194
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 24965446
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL18A: view
genes like me logo Genes that share phenotypes with RPL18A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL18A Gene

Localization for RPL18A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL18A Gene COMPARTMENTS Subcellular localization image for RPL18A gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
genes like me logo Genes that share ontologies with RPL18A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL18A Gene

Pathways & Interactions for RPL18A Gene

genes like me logo Genes that share pathways with RPL18A: view

Pathways by source for RPL18A Gene

1 KEGG pathway for RPL18A Gene
1 GeneGo (Thomson Reuters) pathway for RPL18A Gene

Gene Ontology (GO) - Biological Process for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL18A: view

No data available for SIGNOR curated interactions for RPL18A Gene

Drugs & Compounds for RPL18A Gene

No Compound Related Data Available

Transcripts for RPL18A Gene

mRNA/cDNA for RPL18A Gene

Unigene Clusters for RPL18A Gene

Ribosomal protein L18a:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL18A Gene

No ASD Table

Relevant External Links for RPL18A Gene

GeneLoc Exon Structure for
RPL18A
ECgene alternative splicing isoforms for
RPL18A

Expression for RPL18A Gene

mRNA expression in normal human tissues for RPL18A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL18A Gene

This gene is overexpressed in Tlymphocyte (13.8) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL18A Gene



Protein tissue co-expression partners for RPL18A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL18A Gene:

RPL18A

SOURCE GeneReport for Unigene cluster for RPL18A Gene:

Hs.337766
genes like me logo Genes that share expression patterns with RPL18A: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL18A Gene

Orthologs for RPL18A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL18A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPL18A 34
  • 91.67 (n)
  • 100 (a)
RPL18A 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL18A 34
  • 90.91 (n)
  • 99.43 (a)
RPL18A 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl18a 34
  • 88.83 (n)
  • 99.43 (a)
Rpl18a 16
Rpl18a 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPL18A 34
  • 100 (n)
  • 100 (a)
RPL18A 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl18a 34
  • 88.83 (n)
  • 99.43 (a)
oppossum
(Monodelphis domestica)
Mammalia RPL18A 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL18A 35
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL18A 34
  • 81.23 (n)
  • 95.98 (a)
RPL18A 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL18A 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl18a 34
  • 80.68 (n)
  • 92.61 (a)
Str.18648 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8369 34
zebrafish
(Danio rerio)
Actinopterygii rpl18a 34
  • 79.73 (n)
  • 90.91 (a)
zgc56546 34
rpl18a 35
  • 91 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8991 34
fruit fly
(Drosophila melanogaster)
Insecta RpL18A 36
  • 68 (a)
RpL18A 34
  • 71.59 (n)
  • 68.75 (a)
RpL18A 35
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012284 34
  • 66.67 (n)
  • 66.48 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-20 36
  • 62 (a)
rpl-20 35
  • 60 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR330C 34
  • 57.79 (n)
  • 56.21 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08657g 34
  • 56.55 (n)
  • 59.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL20A 34
  • 55.75 (n)
  • 56.55 (a)
RPL20A 35
  • 55 (a)
OneToMany
RPL20B 35
  • 55 (a)
OneToMany
RPL20B 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G29965 34
  • 54.9 (n)
  • 53.53 (a)
rice
(Oryza sativa)
Liliopsida Os.24956 34
Os01g0752300 34
  • 58.68 (n)
  • 53.89 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9955 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15368 34
bread mold
(Neurospora crassa)
Ascomycetes NCU08389 34
  • 63.94 (n)
  • 60.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2002 34
  • 55.56 (n)
  • 54.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10110 35
  • 62 (a)
OneToOne
Species where no ortholog for RPL18A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL18A Gene

ENSEMBL:
Gene Tree for RPL18A (if available)
TreeFam:
Gene Tree for RPL18A (if available)

Paralogs for RPL18A Gene

genes like me logo Genes that share paralogs with RPL18A: view

No data available for Paralogs for RPL18A Gene

Variants for RPL18A Gene

Sequence variations from dbSNP and Humsavar for RPL18A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs78570499 -- 17,860,218(+) TTCCC(A/G)GGGGA intron-variant
rs79683038 -- 17,859,697(+) ACGCT(C/T)CGTTG upstream-variant-2KB
rs111262297 -- 17,859,926(+) CCTTT(C/T)GCGGG utr-variant-5-prime
rs111657667 -- 17,858,522(+) GACTC(A/G)GTCTC upstream-variant-2KB
rs111837678 -- 17,858,260(+) CGGTG(A/G)CTTAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL18A Gene

Variant ID Type Subtype PubMed ID
nsv833772 CNV gain+loss 17160897
nsv978783 CNV duplication 23825009

Variation tolerance for RPL18A Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL18A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL18A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL18A Gene

Disorders for RPL18A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL18A Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RPL18A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL18A
genes like me logo Genes that share disorders with RPL18A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL18A Gene

Publications for RPL18A Gene

  1. Human ribosomal protein L18a interacts with hepatitis C virus internal ribosome entry site. (PMID: 16195786) Dhar D. … Das S. (Arch. Virol. 2006) 3 22 65
  2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 65
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jaekel S. … Goerlich D. (EMBO J. 2002) 3 4 65

Products for RPL18A Gene

Sources for RPL18A Gene

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