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Aliases for RPL18A Gene

Aliases for RPL18A Gene

  • Ribosomal Protein L18a 2 3 5
  • Large Ribosomal Subunit Protein EL20 3 4
  • Ribosomal Protein L18a-Like Protein 2 3
  • 60S Ribosomal Protein L18a 2 3
  • L18A 3

External Ids for RPL18A Gene

Previous GeneCards Identifiers for RPL18A Gene

  • GC12P103772
  • GC19P018362
  • GC19P017815
  • GC19P017831
  • GC19P017970
  • GC19P017536
  • GC19P017964
  • GC19P018175
  • GC19P018293
  • GC19P018327
  • GC19P018700
  • GC19P019010

Summaries for RPL18A Gene

Entrez Gene Summary for RPL18A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]

GeneCards Summary for RPL18A Gene

RPL18A (Ribosomal Protein L18a) is a Protein Coding gene. Diseases associated with RPL18A include Hepatitis C Virus. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL18A Gene

Additional gene information for RPL18A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL18A Gene

Genomics for RPL18A Gene

Regulatory Elements for RPL18A Gene

Enhancers around RPL18A on UCSC Golden Path with GeneCards custom track

Promoters for RPL18A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the RPL18A gene promoter:

Genomic Locations for RPL18A Gene

Genomic Locations for RPL18A Gene
4,278 bases
Plus strand

Genomic View for RPL18A Gene

Genes around RPL18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL18A Gene

Proteins for RPL18A Gene

  • Protein details for RPL18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L18a
    Protein Accession:

    Protein attributes for RPL18A Gene

    176 amino acids
    Molecular mass:
    20762 Da
    Quaternary structure:
    • Binds IPO9 with high affinity.
    • Sequence=CAA56788.1; Type=Frameshift; Positions=65; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL18A Gene

neXtProt entry for RPL18A Gene

Post-translational modifications for RPL18A Gene

  • Ubiquitination at isoforms=11, Lys21, isoforms=41, isoforms=76, Lys136, Lys143, Lys151, and isoforms=170
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL18A Gene

No data available for DME Specific Peptides for RPL18A Gene

Domains & Families for RPL18A Gene

Gene Families for RPL18A Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPL18A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL20 family.
  • Belongs to the eukaryotic ribosomal protein eL20 family.
genes like me logo Genes that share domains with RPL18A: view

Function for RPL18A Gene

Molecular function for RPL18A Gene

GENATLAS Biochemistry:
60S ribosomal protein L18A

Phenotypes From GWAS Catalog for RPL18A Gene

Gene Ontology (GO) - Molecular Function for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IDA 22658674
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with RPL18A: view
genes like me logo Genes that share phenotypes with RPL18A: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL18A Gene

Localization for RPL18A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL18A gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA,IEA 12962325
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with RPL18A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL18A Gene

Pathways & Interactions for RPL18A Gene

genes like me logo Genes that share pathways with RPL18A: view

Pathways by source for RPL18A Gene

1 KEGG pathway for RPL18A Gene
1 GeneGo (Thomson Reuters) pathway for RPL18A Gene

Gene Ontology (GO) - Biological Process for RPL18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL18A: view

No data available for SIGNOR curated interactions for RPL18A Gene

Drugs & Compounds for RPL18A Gene

No Compound Related Data Available

Transcripts for RPL18A Gene

Unigene Clusters for RPL18A Gene

Ribosomal protein L18a:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL18A Gene

No ASD Table

Relevant External Links for RPL18A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL18A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL18A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL18A Gene

This gene is overexpressed in Tlymphocyte (13.8) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL18A Gene

Protein tissue co-expression partners for RPL18A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL18A Gene:


SOURCE GeneReport for Unigene cluster for RPL18A Gene:


Evidence on tissue expression from TISSUES for RPL18A Gene

  • Nervous system(4.9)
  • Muscle(4.7)
  • Liver(4.6)
  • Lung(4.4)
  • Eye(4.3)
  • Skin(4.1)
  • Pancreas(3.8)
  • Intestine(3.6)
  • Kidney(3.5)
  • Stomach(3.1)
  • Blood(2.8)
  • Heart(2.5)
  • Spleen(2.3)
  • Lymph node(2.2)
  • Thyroid gland(2.2)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with RPL18A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL18A Gene

Orthologs for RPL18A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL18A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL18A 34 33
  • 100 (n)
(Monodelphis domestica)
Mammalia RPL18A 34
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia RPL18A 34
  • 97 (a)
(Bos Taurus)
Mammalia RPL18A 33 34
  • 91.67 (n)
(Canis familiaris)
Mammalia RPL18A 34 33
  • 90.91 (n)
(Mus musculus)
Mammalia Rpl18a 16 34 33
  • 88.83 (n)
(Rattus norvegicus)
Mammalia Rpl18a 33
  • 88.83 (n)
(Gallus gallus)
Aves RPL18A 33 34
  • 81.23 (n)
(Anolis carolinensis)
Reptilia RPL18A 34
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl18a 33
  • 80.68 (n)
Str.18648 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8369 33
(Danio rerio)
Actinopterygii rpl18a 33 34
  • 79.73 (n)
zgc56546 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8991 33
fruit fly
(Drosophila melanogaster)
Insecta RpL18A 33 34 35
  • 71.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012284 33
  • 66.67 (n)
(Caenorhabditis elegans)
Secernentea rpl-20 34 35
  • 60 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR330C 33
  • 57.79 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08657g 33
  • 56.55 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL20A 34 33
  • 55.75 (n)
RPL20B 34 36
  • 55 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G29965 33
  • 54.9 (n)
(Oryza sativa)
Liliopsida Os01g0752300 33
  • 58.68 (n)
Os.24956 33
(Triticum aestivum)
Liliopsida Ta.9955 33
bread mold
(Neurospora crassa)
Ascomycetes NCU08389 33
  • 63.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10110 34
  • 62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2002 33
  • 55.56 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15368 33
Species where no ortholog for RPL18A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL18A Gene

Gene Tree for RPL18A (if available)
Gene Tree for RPL18A (if available)

Paralogs for RPL18A Gene

No data available for Paralogs for RPL18A Gene

Variants for RPL18A Gene

Sequence variations from dbSNP and Humsavar for RPL18A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000078583 -- 17,858,334(+) ACCAG(C/G)CTAAC upstream-variant-2KB
rs1000262 -- 17,859,818(+) CGGGT(C/G)GCTTT upstream-variant-2KB
rs1000338719 -- 17,861,301(+) CGAGA(C/G)TACAA upstream-variant-2KB, reference, missense
rs1000665306 -- 17,860,344(+) CTGCC(A/G)GAATG intron-variant
rs1000718570 -- 17,860,554(+) CCCTT(C/G)CTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL18A Gene

Variant ID Type Subtype PubMed ID
nsv978783 CNV duplication 23825009
nsv833772 CNV gain+loss 17160897

Variation tolerance for RPL18A Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL18A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL18A Gene

Disorders for RPL18A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL18A Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitis c virus, response to therapy of
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RPL18A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL18A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL18A Gene

Publications for RPL18A Gene

  1. Human ribosomal protein L18a interacts with hepatitis C virus internal ribosome entry site. (PMID: 16195786) Dhar D … Das S (Archives of virology 2006) 3 22 60
  2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 60
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jäkel S … Görlich D (The EMBO journal 2002) 3 4 60

Products for RPL18A Gene

Sources for RPL18A Gene

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