Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RPL18 Gene

protein-coding   GIFtS: 65
GCID: GC19M049118

Ribosomal Protein L18

  Search for RPL18
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ribosomal Protein L181 2
60S Ribosomal Protein L181 2
L182

External Ids:    HGNC: 103101   Entrez Gene: 61412   Ensembl: ENSG000000631777   OMIM: 6041795   UniProtKB: Q070203   
ORGUL members:         

Export aliases for RPL18 gene to outside databases

Previous GC identifers: GC19M049758 GC19M049486 GC19M053790 GC19M053810 GC19M053649 GC19M045500


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RPL18 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is
typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed
through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for
this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for RPL18 Gene:
RPL18 (ribosomal protein L18) is a protein-coding gene. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

Gene Wiki entry for RPL18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL18 gene promoter:
         COUP-TF1   ATF-2   COUP   HNF-4alpha2   HNF-4alpha1   CREB   COUP-TF   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL18 promoter sequence
   Search Chromatin IP Primers for RPL18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13

RPL18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL18 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049118:  view genomic region     (about GC identifiers)

Start:
49,118,585 bp from pter      End:
49,122,793 bp from pter
Size:
4,209 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RL18_HUMAN, Q07020 (See protein sequence)
Recommended Name: 60S ribosomal protein L18  
Size: 188 amino acids; 21634 Da
1 PDB 3D structure from and Proteopedia for RPL18:
3J3B (3D)    
Secondary accessions: Q8WTZ6

Explore the universe of human proteins at neXtProt for RPL18: NX_Q07020

Explore proteomics data for RPL18 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys30, Lys49, Lys78, Lys99, Lys119, Lys132, Lys154, Lys164
  • Modification sites at PhosphoSitePlus

  • See RPL18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000970.1  NP_001257419.1  

    ENSEMBL proteins: 
     ENSP00000447001   ENSP00000470988   ENSP00000084795   ENSP00000448899   ENSP00000449204  
     ENSP00000446634   ENSP00000449067   ENSP00000449610   ENSP00000447894  
    Reactome Protein details: Q07020

    RPL18 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RPL18
    OriGene Protein Over-expression Lysate for RPL18
    OriGene MassSpec for RPL18
    OriGene Custom Protein Services for RPL18
    GenScript Custom Purified and Recombinant Proteins Services for RPL18
    Novus Biologicals RPL18 Proteins
    Novus Biologicals RPL18 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPL18

     
    Search eBioscience for Proteins for RPL18 

    RPL18 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RPL18
    OriGene Custom Antibody Services for RPL18
    Novus Biologicals RPL18 Antibodies
    Abcam antibodies for RPL18
    Cloud-Clone Corp. Antibodies for RPL18
    Search ThermoFisher Antibodies for RPL18
    LSBio Antibodies in human, mouse, rat for RPL18

    RPL18 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RPL18
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RPL18
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RPL18
    Cloud-Clone Corp. CLIAs for RPL18
    Search eBioscience for ELISAs for RPL18 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RPL: L ribosomal proteins

    3 InterPro protein domains:
     IPR000039 Ribosomal_L18e
     IPR021131 Ribosomal_L18e/L15P
     IPR021132 Ribosomal_L18e_CS

    Graphical View of Domain Structure for InterPro Entry Q07020

    ProtoNet protein and cluster: Q07020

    1 Blocks protein domain: IPB000039 Ribosomal protein L18e

    UniProtKB/Swiss-Prot: RL18_HUMAN, Q07020
    Similarity: Belongs to the ribosomal protein L18e family


    Find genes that share domains with RPL18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:
         Genatlas biochemistry entry for RPL18:
    60S ribosomal protein L18,21kDa

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS8218404
    GO:0003735structural constituent of ribosome NAS12962325
         
    Find genes that share ontologies with RPL18           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for RPL18:
     Decreased cell number, increas  Decreased viability of wild-ty  Nuclear 60S biogenesis defects  Nucleolar pre-40S maturation d 
     S arrest 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPL18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPL18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPL18

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPL18:
    hsa-let-7b-5p (MIRT051955), hsa-mir-106b-5p (MIRT044312), hsa-mir-744-5p (MIRT037632), hsa-mir-149-5p (MIRT045664)

    Block miRNA regulation of human, mouse, rat RPL18 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RPL18
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RPL18
    Predesigned siRNA for gene silencing in human, mouse, rat RPL18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPL18

    Clone
    Products:
         
    OriGene clones in human, mouse for RPL18 (see all 5)
    OriGene ORF clones in mouse, rat for RPL18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPL18 (NM_000979)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL18

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RPL18
    Browse ESI BIO Cell Lines and PureStem Progenitors for RPL18 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RL18_HUMAN, Q07020: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325

    Find genes that share ontologies with RPL18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RPL18 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease


    Find genes that share SuperPaths with RPL18           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL18
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL18
        Cytoplasmic Ribosomal Proteins

    Selected Reactome Pathways for RPL18 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL18):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL18
    Interactions:

        Search GeneGlobe Interaction Network for RPL18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL18 (Q070202, 3 ENSP000000847954) via UniProtKB, MINT, STRING, and/or I2D (see all 557)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    Find genes that share ontologies with RPL18           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL18 (RL18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RPL18 gene (2 alternative transcripts): 
    NM_000979.3  NM_001270490.1  

    Unigene Cluster for RPL18:

    Ribosomal protein L18
    Hs.515517  [show with all ESTs]
    Unigene Representative Sequence: BF970882
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552347 ENST00000549920(uc002pjq.1) ENST00000547897 ENST00000549533
    ENST00000084795 ENST00000550645 ENST00000552588 ENST00000551749(uc021uwv.1)
    ENST00000547892 ENST00000546623 ENST00000549370 ENST00000549273 ENST00000550973
    ENST00000552705(uc010xzs.1) ENST00000552851 ENST00000550671
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RPL18 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RPL18
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RPL18
    Predesigned siRNA for gene silencing in human, mouse, rat RPL18
    Clone
    Products:
         
    OriGene clones in human, mouse for RPL18 (see all 5)
    OriGene ORF clones in mouse, rat for RPL18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPL18 (NM_000979)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL18
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RPL18
    OriGene qSTAR qPCR primer pairs in human, mouse for RPL18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPL18
      QuantiTect SYBR Green Assays in human, mouse, rat RPL18
      QuantiFast Probe-based Assays in human, mouse, rat RPL18

    Additional mRNA sequence: 

    AK026558.1 BC000374.2 BC009708.2 BC021743.2 L11566.1 NR_073022.1 

    Selected DOTS entries (see all 43):

    DT.91777742  DT.100863665  DT.97769191  DT.100698677  DT.91940272  DT.87077878  DT.87045650  DT.87045659 
    DT.100698690  DT.91687461  DT.120703968  DT.100698678  DT.100698683  DT.100698688  DT.100698689  DT.100730344 
    DT.102840066  DT.97864800  DT.91777744  DT.91777733  DT.91777720  DT.121411855  DT.95240055  DT.102840057 

    Selected AceView cDNA sequences (see all 1955):

    BQ941651 BQ060904 BF725133 BF686186 BI836470 BM928180 BM797756 AI028755 
    AW248220 BU628999 BE794922 BE294271 BM016290 BQ433202 BU860304 BM314411 
    BM811292 BM772194 CA941925 AA328762 BM911464 CB068642 BM874707 AA380466 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RPL18    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8
    SP1:                                -           -                           
    SP2:                                -                             -         
    SP3:                                -                                       
    SP4:        -                                                               
    SP5:        -                                                               


    ECgene alternative splicing isoforms for RPL18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RPL18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGTGGACA
    RPL18 Expression
    About this image


    RPL18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Gonad
             Primary Oocyte Primary Follicle
    RPL18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515517
        Custom PCR Arrays for RPL18
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RPL18
    OriGene qSTAR qPCR primer pairs in human, mouse for RPL18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPL18
    QuantiTect SYBR Green Assays in human, mouse, rat RPL18
    QuantiFast Probe-based Assays in human, mouse, rat RPL18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL18 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl181 , 5 ribosomal protein L181, 5 88.65(n)1
    96.28(a)1
      7 (29.45 cM)5
    198991  NM_009077.21  NP_033103.21 
     457154575 
    lizard
    (Anolis carolinensis)
    Reptilia RPL186
    ribosomal protein L18
    88(a)
    1 ↔ 1
    GL343279.1(944795-955056)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC053773.12   -- 75.17(n)    BC053773.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570355122   -- 72.36(n)    57035512 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG86153
    RpL181
    protein biosynthesis structural
    constituent of more3
    Ribosomal protein L181
    69(a)3
    62.29(n)1
    68.57(a)1
      65F13
    387941  NM_001274572.11  NP_001261501.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-181 , 3 Eukaryotic ribosomal protein L183
    rpl-181
    65(a)3
    58.87(n)1
    65.96(a)1
      IV(13778060-13778917)3
    1783421  NM_070254.41  NP_502655.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL18B(YNL301C)4
    RPL18B1
    Protein component of the large (60S) ribosomal subunit, more4
    RPL18B1
    54.07(n)1
    55.23(a)1
      14(64562-63570)4
    8554151, 4  NP_014098.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RPL181 RPL18 58.57(n)
    65.32(a)
      819725  NM_111432.3  NP_187210.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01551001 Os05g0155100 61.3(n)
    65.52(a)
      4337849  NM_001061223.1  NP_001054688.1 


    ENSEMBL Gene Tree for RPL18 (if available)
    TreeFam Gene Tree for RPL18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RPL18 gene
    1 SIMAP similar gene for RPL18 using alignment to 9 protein entries:     RL18_HUMAN (see all proteins):
    LOC136143

    Find genes that share paralogs with RPL18           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RPL18 (see all 15)
    PGOHUM00000242643 PGOHUM00000239298 PGOHUM00000248592 PGOHUM00000247828 PGOHUM00000261159


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RPL18 (see all 80)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406511781,2
    C--49118720(+) AGGAGG/AGAGTG 3 -- int12Minor allele frequency- A:0.00NS EU 991
    rs1808233471,2
    C--49118732(+) GAGGGC/GGGCCC 3 -- int10--------
    rs2018958671,2
    --49118733(+) AGGGGG/TGCCCT 3 -- int10--------
    rs772245721,2
    F--49119044(+) GGTACG/AAGGGA 3 -- int11Minor allele frequency- A:0.01WA 118
    rs1862593121,2
    C--49119113(+) GGCAGA/GGCTGG 3 -- int10--------
    rs2008800361,2
    --49119189(+) CTCTCG/TGCCCT 5 R syn10--------
    rs1129685561,2
    C--49119205(+) GGACCA/G/TAGGGA 3 -- spa11CSA 1
    rs1135317661,2
    C--49119206(+) GACCTA/G/TGGGAA 3 -- int11CSA 1
    rs2001883691,2
    C--49119208(+) CCTAGG/TGAAGG 3 -- int10--------
    rs2022129861,2
    --49119213(+) GGAAGA/GGGAAG 3 -- int10--------

    HapMap Linkage Disequilibrium report for RPL18 (49118585 - 49122793 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RPL18:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912234CNV Loss21882294
    dgv3967n71CNV Loss21882294
    nsv912225CNV Loss21882294
    dgv3966n71CNV Loss21882294
    esv1003432CNV Gain20482838
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL18
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604179    OMIM disorders: --


    Find genes that share disorders with RPL18           About GenesLikeMe

    Genetic Association Database (GAD): RPL18
    Human Genome Epidemiology (HuGE) Navigator: RPL18 (3 documents)

    Export disorders for RPL18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RPL18 gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with RPL18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide and deduced amino acid sequence of human ribosomal protein L18. (PubMed id 8218404)1, 2, 3, 9 Puder M.... Chen L.B. (Biochim. Biophys. Acta 1993)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (J. Protein Chem. 2003)
    6. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    7. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    8. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (RNA 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6141 HGNC: 10310 AceView: RPL18 Ensembl:ENSG00000063177 euGenes: HUgn6141
    ECgene: RPL18 Kegg: 6141 H-InvDB: RPL18

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RPL18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RPL18 gene:
    Search GeneIP for patents involving RPL18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RPL18   OriGene RNAi products in human, mouse, rat for RPL18  
     OriGene qPCR primer pairs and template standards for RPL18   OriGene Protein Over-expression Lysate for RPL18  
     OriGene MassSpec something-or-other for RPL18   OriGene clones in human, mouse for RPL18  
     OriGene qSTAR qPCR primer pairs in human, mouse for RPL18   OriGene Purified Protein for RPL18  
     OriGene ORF clones in mouse, rat for RPL18   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPL18   OriGene Custom Protein Services for RPL18  

     
     
     Block miRNA regulation of human, mouse, rat RPL18 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RPL18
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL18 Predesigned siRNA for gene silencing in human, mouse, rat RPL18
     QuantiFast Probe-based Assays in human, mouse, rat RPL18 QuantiTect SYBR Green Assays in human, mouse, rat RPL18
     Custom PCR Arrays for RPL18 Search Chromatin IP Primers for RPL18
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPL18  Search GeneGlobe Interaction Network for RPL18
     Regulatory tfbs in RPL18 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RPL18 GenScript cDNA clones with any tag delivered in your preferred vector for RPL18
     GenScript Custom Assay Services for RPL18 GenScript Custom overexpressing Cell Line Services for RPL18
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RPL18 (RL18)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RPL18 antibodies
     RPL18 proteins
     RPL18 lysates
     Antibodies for RPL18
     See all of Abcam's Antibodies, Kits and Proteins for RPL18
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RPL18
     Antibodies for RPL18
     ELISAs for RPL18
     CLIAs for RPL18



     Browse ESI BIO Cell Lines and PureStem Progenitors for RPL18
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL18
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RPL18
     SwitchGear Promoter luciferase reporter plasmids for RPL18
     Search ThermoFisher Antibodies for RPL18
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL18
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL18
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPL18
     LSBio Antibodies in human, mouse, rat for RPL18
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RPL18
      Search eBioscience for proteins for RPL18
      Search eBioscience for elisas for RPL18
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RPL18 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4