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Aliases for RPL18 Gene

Subcategory (RNA class) for RPL18 Gene

lncRNA

Aliases for RPL18 Gene

  • Ribosomal Protein L18 2 3 5
  • Large Ribosomal Subunit Protein EL18 3 4
  • 60S Ribosomal Protein L18 2 3
  • L18 3

External Ids for RPL18 Gene

ORGUL Members for RPL18 Gene

Previous GeneCards Identifiers for RPL18 Gene

  • GC19M049758
  • GC19M049486
  • GC19M053790
  • GC19M053810
  • GC19M053649
  • GC19M049118
  • GC19M045500

Summaries for RPL18 Gene

Entrez Gene Summary for RPL18 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for RPL18 Gene

RPL18 (Ribosomal Protein L18) is a Protein Coding gene, and is affiliated with the lncRNA class. Among its related pathways are Viral mRNA Translation and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL18 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL18 Gene

Genomics for RPL18 Gene

Regulatory Elements for RPL18 Gene

Enhancers for RPL18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G049494 2 FANTOM5 Ensembl ENCODE dbSUPER 21.2 -879.5 -879508 9.7 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC RPS11 ALDH16A1 SNORD35A PIH1D1 SNORD35B RPL18 FLT3LG PRR12 CD37 POLD1
GH19G048632 1.7 Ensembl ENCODE dbSUPER 21.6 -16.9 -16941 7.8 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PRR12 ENSG00000268093 GRWD1 RPS11 SNORD35A PIH1D1 RPL18 NOP53-AS1 SNORD35B ALDH16A1
GH19G048612 1.7 Ensembl ENCODE dbSUPER 20.7 +2.8 2774 7.8 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3 NFYC PRR12 SNORD35A KDELR1 SNORD35B ALDH16A1 GRWD1 SEC1P NOP53-AS1 RPS11 PIH1D1
GH19G048362 1.2 ENCODE 21.3 +255.5 255544 2.7 CREB3L1 YBX1 FEZF1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D SSRP1 RPL18 NOP53-AS1 ENSG00000268746 KDELR1 CCDC114 BICRA GRWD1 SNORD23 DKKL1 EHD2
GH19G048958 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -344.5 -344494 10.2 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 PPP1R15A PRR12 NUP62 IZUMO1 RUVBL2 CA11 SEC1P SNORD35B C19orf68 ALDH16A1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL18 on UCSC Golden Path with GeneCards custom track

Promoters for RPL18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110740 418 2001 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21

Genomic Location for RPL18 Gene

Chromosome:
19
Start:
48,615,327 bp from pter
End:
48,619,536 bp from pter
Size:
4,210 bases
Orientation:
Minus strand

Genomic View for RPL18 Gene

Genes around RPL18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL18 Gene

Proteins for RPL18 Gene

  • Protein details for RPL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07020-RL18_HUMAN
    Recommended name:
    60S ribosomal protein L18
    Protein Accession:
    Q07020
    Secondary Accessions:
    • F8VWC5
    • Q8WTZ6

    Protein attributes for RPL18 Gene

    Size:
    188 amino acids
    Molecular mass:
    21634 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL18 Gene

    Alternative splice isoforms for RPL18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPL18 Gene

Post-translational modifications for RPL18 Gene

  • Ubiquitination at Lys49, isoforms=278, Lys99, isoforms=2119, isoforms=2154, and isoforms=2164
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL18 Gene

Domains & Families for RPL18 Gene

Protein Domains for RPL18 Gene

Suggested Antigen Peptide Sequences for RPL18 Gene

Graphical View of Domain Structure for InterPro Entry

Q07020

UniProtKB/Swiss-Prot:

RL18_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL18 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL18 family.
genes like me logo Genes that share domains with RPL18: view

No data available for Gene Families for RPL18 Gene

Function for RPL18 Gene

Molecular function for RPL18 Gene

GENATLAS Biochemistry:
60S ribosomal protein L18,21kDa

Gene Ontology (GO) - Molecular Function for RPL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8218404
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
genes like me logo Genes that share ontologies with RPL18: view
genes like me logo Genes that share phenotypes with RPL18: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL18 Gene

Localization for RPL18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL18 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL18 gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for RPL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 21630459
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA --
genes like me logo Genes that share ontologies with RPL18: view

Pathways & Interactions for RPL18 Gene

genes like me logo Genes that share pathways with RPL18: view

Pathways by source for RPL18 Gene

1 KEGG pathway for RPL18 Gene
1 GeneGo (Thomson Reuters) pathway for RPL18 Gene

Gene Ontology (GO) - Biological Process for RPL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL18: view

No data available for SIGNOR curated interactions for RPL18 Gene

Drugs & Compounds for RPL18 Gene

No Compound Related Data Available

Transcripts for RPL18 Gene

Unigene Clusters for RPL18 Gene

Ribosomal protein L18:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL18 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: -

Relevant External Links for RPL18 Gene

GeneLoc Exon Structure for
RPL18
ECgene alternative splicing isoforms for
RPL18

Expression for RPL18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL18 Gene

This gene is overexpressed in Tlymphocyte (10.8) and Nasal epithelium (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL18 Gene



Protein tissue co-expression partners for RPL18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL18 Gene:

RPL18

SOURCE GeneReport for Unigene cluster for RPL18 Gene:

Hs.515517

Evidence on tissue expression from TISSUES for RPL18 Gene

  • Nervous system(5)
  • Lung(4.9)
  • Intestine(4.8)
  • Liver(4.8)
  • Pancreas(4.7)
  • Skin(4.4)
  • Eye(4.2)
  • Muscle(3.4)
  • Stomach(3.3)
  • Blood(3.2)
  • Heart(3.1)
  • Kidney(3)
  • Lymph node(2.9)
  • Bone marrow(2.8)
  • Adrenal gland(2.7)
  • Spleen(2.7)
  • Thyroid gland(2.7)
  • Gall bladder(2.6)
  • Bone(2)
genes like me logo Genes that share expression patterns with RPL18: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL18 Gene

Orthologs for RPL18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL18 34 35
  • 98.58 (n)
oppossum
(Monodelphis domestica)
Mammalia RPL18 35
  • 94 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPL18 34 35
  • 90.78 (n)
cow
(Bos Taurus)
Mammalia RPL18 34 35
  • 90.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPL18 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl18 34 16 35
  • 88.65 (n)
rat
(Rattus norvegicus)
Mammalia Rpl18 34
  • 88.48 (n)
lizard
(Anolis carolinensis)
Reptilia RPL18 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl18 34
  • 74.11 (n)
zebrafish
(Danio rerio)
Actinopterygii rpl18 34 35
  • 75.43 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8673 34
fruit fly
(Drosophila melanogaster)
Insecta CG8615 36
  • 69 (a)
RpL18 34 35
  • 62.29 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta RL18_ANOGA 34
  • 65.07 (n)
worm
(Caenorhabditis elegans)
Secernentea rpl-18 36 34 35
  • 58.87 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL18A 35
  • 55 (a)
OneToMany
RPL18B 34 35 37
  • 54.07 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL157C 34
  • 54.07 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07227g 34
  • 51.55 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPL18 34
  • 58.57 (n)
soybean
(Glycine max)
eudicotyledons Gma.1197 34
rice
(Oryza sativa)
Liliopsida Os05g0155100 34
  • 61.3 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.12865 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4938 35
  • 73 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU03988 34
  • 63.53 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl1802 34
  • 56.98 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4926 34
Species where no ortholog for RPL18 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL18 Gene

ENSEMBL:
Gene Tree for RPL18 (if available)
TreeFam:
Gene Tree for RPL18 (if available)

Paralogs for RPL18 Gene

No data available for Paralogs for RPL18 Gene

Variants for RPL18 Gene

Sequence variations from dbSNP and Humsavar for RPL18 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000516718 -- 48,618,471(+) TACCG(A/C/T)CCTGC intron-variant, upstream-variant-2KB
rs1001216090 -- 48,617,562(+) AGAAA(A/G)CTGGC intron-variant, upstream-variant-2KB
rs1001586851 -- 48,618,260(+) CCTAG(-/CAATACTACTAGAACCA)CCTCT intron-variant, upstream-variant-2KB
rs1002111853 -- 48,620,760(+) CTCTA(C/T)TAAAA intron-variant, upstream-variant-2KB
rs1002227476 -- 48,614,911(+) TCCGG(A/G)GGTGC downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL18 Gene

Variant ID Type Subtype PubMed ID
dgv3617n100 CNV gain 25217958
esv1003432 CNV gain 20482838
nsv9739 CNV gain+loss 18304495

Variation tolerance for RPL18 Gene

Residual Variation Intolerance Score: 28.4% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL18 Gene

Disorders for RPL18 Gene

Relevant External Links for RPL18

Genetic Association Database (GAD)
RPL18
Human Genome Epidemiology (HuGE) Navigator
RPL18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL18

No disorders were found for RPL18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL18 Gene

Publications for RPL18 Gene

  1. Nucleotide and deduced amino acid sequence of human ribosomal protein L18. (PMID: 8218404) Puder M. … Chen L.B. (Biochim. Biophys. Acta 1993) 2 3 4 22 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova T.I. … Karpova G.G. (J. Protein Chem. 2003) 3 4 64

Products for RPL18 Gene

Sources for RPL18 Gene

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