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Aliases for RPL18 Gene

Subcategory (RNA class) for RPL18 Gene


Aliases for RPL18 Gene

  • Ribosomal Protein L18 2 3 5
  • 60S Ribosomal Protein L18 2
  • L18 3

External Ids for RPL18 Gene

ORGUL Members for RPL18 Gene

Previous GeneCards Identifiers for RPL18 Gene

  • GC19M049758
  • GC19M049486
  • GC19M053790
  • GC19M053810
  • GC19M053649
  • GC19M049118
  • GC19M045500

Summaries for RPL18 Gene

Entrez Gene Summary for RPL18 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for RPL18 Gene

RPL18 (Ribosomal Protein L18) is a Protein Coding gene, and is affiliated with the lncRNA class. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL18 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL18 Gene

Genomics for RPL18 Gene

Regulatory Elements for RPL18 Gene

Enhancers for RPL18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPL18 on UCSC Golden Path with GeneCards custom track

Promoters for RPL18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL18 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL18 Gene

48,615,327 bp from pter
48,619,536 bp from pter
4,210 bases
Minus strand

Genomic View for RPL18 Gene

Genes around RPL18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL18 Gene

Proteins for RPL18 Gene

  • Protein details for RPL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L18
    Protein Accession:
    Secondary Accessions:
    • F8VWC5
    • Q8WTZ6

    Protein attributes for RPL18 Gene

    188 amino acids
    Molecular mass:
    21634 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL18 Gene

    Alternative splice isoforms for RPL18 Gene


neXtProt entry for RPL18 Gene

Proteomics data for RPL18 Gene at MOPED

Post-translational modifications for RPL18 Gene

  • Ubiquitination at Lys 49, Lys 78, Lys 99, Lys 119, Lys 154, and Lys 164
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for RPL18

No data available for DME Specific Peptides for RPL18 Gene

Domains & Families for RPL18 Gene

Protein Domains for RPL18 Gene

Suggested Antigen Peptide Sequences for RPL18 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L18e family.
  • Belongs to the ribosomal protein L18e family.
genes like me logo Genes that share domains with RPL18: view

No data available for Gene Families for RPL18 Gene

Function for RPL18 Gene

Molecular function for RPL18 Gene

GENATLAS Biochemistry:
60S ribosomal protein L18,21kDa
genes like me logo Genes that share phenotypes with RPL18: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL18 Gene

Localization for RPL18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL18 Gene


Subcellular locations from

Jensen Localization Image for RPL18 Gene COMPARTMENTS Subcellular localization image for RPL18 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for RPL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL18: view

Pathways & Interactions for RPL18 Gene

genes like me logo Genes that share pathways with RPL18: view

Pathways by source for RPL18 Gene

1 KEGG pathway for RPL18 Gene
1 GeneGo (Thomson Reuters) pathway for RPL18 Gene

Gene Ontology (GO) - Biological Process for RPL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with RPL18: view

No data available for SIGNOR curated interactions for RPL18 Gene

Drugs & Compounds for RPL18 Gene

No Compound Related Data Available

Transcripts for RPL18 Gene

Unigene Clusters for RPL18 Gene

Ribosomal protein L18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL18 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: -

Relevant External Links for RPL18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL18 Gene

mRNA expression in normal human tissues for RPL18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL18 Gene

This gene is overexpressed in Tlymphocyte (10.8) and Nasal epithelium (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL18 Gene

SOURCE GeneReport for Unigene cluster for RPL18 Gene Hs.515517

genes like me logo Genes that share expression patterns with RPL18: view

Protein tissue co-expression partners for RPL18 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL18 Gene

Orthologs for RPL18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL18 35
  • 90.25 (n)
  • 98.4 (a)
RPL18 36
  • 98 (a)
(Canis familiaris)
Mammalia RPL18 35
  • 90.78 (n)
  • 98.94 (a)
RPL18 36
  • 99 (a)
(Mus musculus)
Mammalia Rpl18 35
  • 88.65 (n)
  • 96.28 (a)
Rpl18 16
Rpl18 36
  • 96 (a)
(Pan troglodytes)
Mammalia RPL18 35
  • 98.58 (n)
  • 100 (a)
RPL18 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rpl18 35
  • 88.48 (n)
  • 96.81 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
RPL18 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia RPL18 36
  • 90 (a)
(Anolis carolinensis)
Reptilia RPL18 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl18 35
  • 74.11 (n)
  • 88.3 (a)
(Danio rerio)
Actinopterygii rpl18 35
  • 75.43 (n)
  • 85.71 (a)
rpl18 36
  • 86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8673 35
fruit fly
(Drosophila melanogaster)
Insecta CG8615 37
  • 69 (a)
RpL18 35
  • 62.29 (n)
  • 68.57 (a)
RpL18 36
  • 69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta RL18_ANOGA 35
  • 65.07 (n)
  • 67.55 (a)
(Caenorhabditis elegans)
Secernentea rpl-18 37
  • 65 (a)
rpl-18 35
  • 58.87 (n)
  • 65.96 (a)
rpl-18 36
  • 66 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL157C 35
  • 54.07 (n)
  • 54.65 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07227g 35
  • 51.55 (n)
  • 53.49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL18B 35
  • 54.07 (n)
  • 55.23 (a)
RPL18A 36
  • 55 (a)
RPL18B 36
  • 55 (a)
RPL18B 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RPL18 35
  • 58.57 (n)
  • 65.32 (a)
(Glycine max)
eudicotyledons Gma.1197 35
(Hordeum vulgare)
Liliopsida Hv.12865 35
(Oryza sativa)
Liliopsida Os05g0155100 35
  • 61.3 (n)
  • 65.52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4926 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03988 35
  • 63.53 (n)
  • 61.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl1802 35
  • 56.98 (n)
  • 59.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4938 36
  • 73 (a)
Species with no ortholog for RPL18:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL18 Gene

Gene Tree for RPL18 (if available)
Gene Tree for RPL18 (if available)

Paralogs for RPL18 Gene

(1) SIMAP similar genes for RPL18 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with RPL18: view

No data available for Paralogs for RPL18 Gene

Variants for RPL18 Gene

Sequence variations from dbSNP and Humsavar for RPL18 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs140705084 -- 48,617,275(+) CCCAG(A/C/T)GGCTC intron-variant
rs34066859 -- 48,617,249(+) CTGCC(-/T)TCCCT intron-variant
rs35665100 -- 48,617,050(+) GACAT(-/A)AAAAC intron-variant
rs371907979 -- 48,616,842(+) AGGAT(A/G/T)TACGT intron-variant
rs372385296 -- 48,616,871(+) TTACA(C/T)TCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL18 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv3966n71 CNV Loss 21882294
nsv912225 CNV Loss 21882294
dgv3967n71 CNV Loss 21882294
nsv912234 CNV Loss 21882294
esv1003432 CNV Gain 20482838

Variation tolerance for RPL18 Gene

Residual Variation Intolerance Score: 28.4% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPL18 Gene

Disorders for RPL18 Gene

Relevant External Links for RPL18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL18 Gene

Publications for RPL18 Gene

  1. Nucleotide and deduced amino acid sequence of human ribosomal protein L18. (PMID: 8218404) Puder M. … Chen L.B. (Biochim. Biophys. Acta 1993) 2 3 4 23 67
  2. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  3. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. (PMID: 25670202) Rashidian J. … Luo K. (Sci Signal 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for RPL18 Gene

Sources for RPL18 Gene