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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL17-C18orf32 Gene

protein-coding   GIFtS: 27
GCID: GC18M047009

RPL17-C18orf32 Readthrough

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RPL17-C18orf32 Readthrough1 2
RPL17-C18orf32 Protein2
60S Ribosomal Protein L233
PD-13

External Ids:    HGNC: 446611   Entrez Gene: 1005268422   Ensembl: ENSG000002154727   UniProtKB: P186213   

Export aliases for RPL17-C18orf32 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL17-C18orf32 Gene:
This locus represents naturally occurring read-through transcription between the neighboring RPL17 (ribosomal
protein L17) and C18orf32 (chromosome 18 open reading frame 32) genes. Alternative splicing results in multiple
transcript variants. The encoded isoforms share sequence identity with the RPL17 protein, but they include
frameshifted C-terminal regions derived from the downstream gene exons. (provided by RefSeq, Dec 2010)

GeneCards Summary for RPL17-C18orf32 Gene: 
RPL17-C18orf32 (RPL17-C18orf32 readthrough) is a protein-coding gene. Diseases associated with RPL17-C18orf32 include influenza, and pancreatitis, and among its related super-pathways are Viral mRNA Translation. An important paralog of this gene is RPL17.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for RPL17-C18orf32
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RPL17-C18orf32

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL17-C18orf32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21.1

RPL17-C18orf32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL17-C18orf32 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M047009:  view genomic region     (about GC identifiers)

Start:
47,007,548 bp from pter      End:
47,018,935 bp from pter
Size:
11,388 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RL17_HUMAN, P18621 (See protein sequence)
Recommended Name: 60S ribosomal protein L17  
Size: 184 amino acids; 21397 Da
1 PDB 3D structure from and Proteopedia for RPL17-C18orf32:
3J3B (3D)    
Secondary accessions: B2R4H3 B4E3C2 B5ME31 J3QL51 Q3KQW2 Q6NZ54 Q7M4M5
Alternative splicing: 3 isoforms:  P18621-1   P18621-2   P18621-3   

Explore the universe of human proteins at neXtProt for RPL17-C18orf32: NX_P18621

Explore proteomics data for RPL17-C18orf32 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P18621

  • RPL17-C18orf32 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPL17-C18orf32 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186284.1  NP_001186285.1  

    ENSEMBL proteins: 
     ENSP00000463379   ENSP00000352143   ENSP00000463338  
    Reactome Protein details: P18621
    Human Recombinant Protein Products for RPL17-C18orf32: 
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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol ----
    GO:0005840ribosome ----
    GO:0015934large ribosomal subunit ----
    GO:0022625cytosolic large ribosomal subunit ----

    RPL17-C18orf32 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001063 Ribosomal_L22
     IPR005721 Ribosomal_L22/L17_euk/arc
     IPR018260 Ribosomal_L22/L17_CS

    Graphical View of Domain Structure for InterPro Entry P18621

    ProtoNet protein and cluster: P18621

    1 Blocks protein domain: IPB001063 Ribosomal protein L22/L17

    UniProtKB/Swiss-Prot: RL17_HUMAN, P18621
    Similarity: Belongs to the ribosomal protein L22P family


    RPL17-C18orf32 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome ----
         
    RPL17-C18orf32 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPL17-C18orf32 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Cytoplasmic Ribosomal Proteins0.65

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RPL17-C18orf32
        Cytoplasmic Ribosomal Proteins

    5/23        Reactome Pathways for RPL17-C18orf32 (see all 23)
        Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Eukaryotic Translation Initiation



    RPL17-C18orf32 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL17-C18orf32

    5/228 Interacting proteins for RPL17-C18orf32 (P186212, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 228)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL4P365782, 3MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=2 
    EEF1A1P681042, 3MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 
    RPL11P629132, 3MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 
    RPL13AP404292, 3MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 
    RPL26P612542, 3MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ----
    GO:0006412translation ----
    GO:0006413translational initiation ----
    GO:0006414translational elongation ----
    GO:0006415translational termination ----

    RPL17-C18orf32 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL17-C18orf32 (RL17)

    Search CenterWatch for drugs/clinical trials and news about RPL17-C18orf32 / RL17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPL17-C18orf32 gene (2 alternative transcripts): 
    NM_001199355.1  NM_001199356.1  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000584895(uc002ldm.2 uc021ujt.1) ENST00000332968 ENST00000577910

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See RPL17-C18orf32 Protein Expression from SPIRE MOPED and PaxDB

    UniProtKB/Swiss-Prot: RL17_HUMAN, P18621
    Tissue specificity: Expressed in pancreas, lung, colon, cystic duct, gall bladder, kidney and liver. Expressed at
    high levels in the well differentiated pancreatic tumor cell lines HPAF, COLO 357 and Capan-1, the moderately
    differentiated pancreatic tumor cell lines T3M-4, AsPc-1 and BxPc-3, the poorly differentiated pancreatic tumor
    cell line MIA PaCa-2, and the pancreatic tumor cell lines of undefined differentiation status such as SW979.
    Expressed at lower levels in the poorly differentiated pancreatic tumor cell lines HCG-25 and PANC-1

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RPL17-C18orf32 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm101661 , 5 predicted pseudogene 101661, 5 86.82(n)1
    94.92(a)1
      7 (21.88 cM)5
    1000438721  XM_001481155.31  XP_001481205.31 
     361182745 
    chicken
    (Gallus gallus)
    Aves RPL171 60S ribosomal protein L17-like 81.17(n)
    96.05(a)
      770025  XM_001231653.2  XP_001231654.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPL17-C18orf326
    RPL17-C18orf32 readthrough
    87(a)
    1 ↔ 1
    2(175798-176641)
    zebrafish
    (Danio rerio)
    Actinopterygii rpl176
    ribosomal protein L17
    89(a)
    1 → many
    21(17812615-17882629)
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL176
    Ribosomal protein L17
    66(a)
    1 → many
    X(6635570-6638290)
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-176
    60S ribosomal protein L17
    61(a)
    1 → many
    I(1156577-1157462)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL17A6
    RPL17B6
    Protein component of the large (60S) ribosomal sub...
    Protein component of the large (60S) ribosomal sub...
    51(a)
    51(a)
    many ↔ many
    many ↔ many
    XI(109269-110129)
    X(90786-91657)


    ENSEMBL Gene Tree for RPL17-C18orf32 (if available)
    TreeFam Gene Tree for RPL17-C18orf32 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL17-C18orf32 gene
    RPL172  

    RPL17-C18orf32 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for RPL17-C18orf32
    PGOHUM00000247871 PGOHUM00000259283 PGOHUM00000240885 PGOHUM00000260059


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing RPL17-C18orf32
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL17-C18orf32

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for RPL17-C18orf32:    About MalaCards
    influenza    pancreatitis


    RPL17-C18orf32 for disorders           About GeneDecksing


    Export disorders for RPL17-C18orf32 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL17-C18orf32 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with RPL17-C18orf32)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (2013)
    2. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    8. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. (PubMed id 20639865)1 Xu G....Jaffrey S.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100526842 HGNC: 44661 Ensembl:ENSG00000215472 euGenes: HUgn100526842 ECgene: RPL17-C18orf32
    H-InvDB: RPL17-C18orf32

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPL17-C18orf32 gene:
    Search GeneIP for patents involving RPL17-C18orf32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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