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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL17-C18orf32 Gene

protein-coding   GIFtS: 26
GCID: GC18M047009

RPL17-C18orf32 readthrough
  Search for RPL17-C18orf32
in
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 Human Malady Compendium 
Biological research products
for RPL17-C18orf32    

Aliases
for RPL17-C18orf32 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RPL17-C18orf32 Readthrough1 2
RPL17-C18orf32 Protein2
60S Ribosomal Protein L233
PD-13

External Ids:    HGNC: 446611   Entrez Gene: 1005268422   Ensembl: ENSG000002154727   UniProtKB: P186213   

Export aliases for RPL17-C18orf32 gene to outside databases


Summaries
for RPL17-C18orf32 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPL17-C18orf32:
This locus represents naturally occurring read-through transcription between the neighboring RPL17 (ribosomal protein
L17) and C18orf32 (chromosome 18 open reading frame 32) genes. Alternative splicing results in multiple transcript
variants. The encoded isoforms share sequence identity with the RPL17 protein, but they include frameshifted
C-terminal regions derived from the downstream gene exons. (provided by RefSeq, Dec 2010)




Genomic Views
for RPL17-C18orf32 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for RPL17-C18orf32
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RPL17-C18orf32

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL17-C18orf32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21.1

RPL17-C18orf32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL17-C18orf32 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M047009:  view genomic region     (about GC identifiers)

Start:
 47,008,051 bp from pter      End:
 47,018,906 bp from pter
Size:
 10,856 bases      Orientation:
 minus strand

Proteins
for RPL17-C18orf32 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RL17_HUMAN, P18621 (See protein sequence)
Recommended Name: 60S ribosomal protein L17  
Size: 184 amino acids; 21397 Da
Secondary accessions: B2R4H3 B4E3C2 B5ME31 Q3KQW2 Q6NZ54 Q7M4M5
Alternative splicing: 2 isoforms:  P18621-1   P18621-2   

Explore the universe of human proteins at neXtProt for RPL17-C18orf32: NX_P18621

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P18621

    • RPL17-C18orf32 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186284.1  NP_001186285.1  

    ENSEMBL proteins: 
     ENSP00000463379   ENSP00000463338   ENSP00000397798   ENSP00000389465   ENSP00000352143  
    Reactome Protein details: P18621
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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol ----
    GO:0015934large ribosomal subunit ----
    GO:0022625cytosolic large ribosomal subunit ----


    RPL17-C18orf32 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RPL17-C18orf32 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RPL17-C18orf32 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001063 Ribosomal_L22
     IPR005721 Ribosomal_L22/L17_euk/arc
     IPR018260 Ribosomal_L22/L17_CS

    Graphical View of Domain Structure for InterPro Entry P18621

    ProtoNet protein and cluster: P18621

    1 Blocks protein family: IPB001063 Ribosomal protein L22/L17

    UniProtKB/Swiss-Prot: RL17_HUMAN, P18621
    Similarity: Belongs to the ribosomal protein L22P family


    Function
    for RPL17-C18orf32 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome ----


    RPL17-C18orf32 for ontologies           About GeneDecksing



    Pathways & Interactions
    for RPL17-C18orf32 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    		Cytoplasmic Ribosomal Proteins0.86

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for RPL17-C18orf32 
        Cytoplasmic Ribosomal Proteins

    5/28        Reactome Pathways for RPL17-C18orf32 (see all 28)
        Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Eukaryotic Translation Initiation



    RPL17-C18orf32 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL17-C18orf32

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/303 Interacting proteins for RPL17-C18orf32 (P186212, 3 ENSP000003894654) via UniProtKB, MINT, STRING, and/or I2D (see all 303)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL4P365782, 3, ENSP000003114304MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=2 STRING: ENSP00000311430
    RPL11P629132, 3, ENSP000003636764MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000363676
    RPL26P612542, 3, ENSP000002938424MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000293842
    RPL27AP467762, 3, ENSP000003460154MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000346015
    RPL35P427662, 3, ENSP000002594694MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000259469
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ----
    GO:0006412translation ----
    GO:0006413translational initiation ----
    GO:0006414translational elongation ----
    GO:0006415translational termination ----


    RPL17-C18orf32 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPL17-C18orf32 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RPL17-C18orf32
    Search CenterWatch for drugs/clinical trials and news about RPL17-C18orf32 / RL17 

    Transcripts
    for RPL17-C18orf32 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPL17-C18orf32 gene (2 alternative transcripts): 
    NM_001199355.1  NM_001199356.1  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000584895(uc002ldm.2 uc021ujt.1) ENST00000577910 ENST00000418495(uc002ldp.3 uc021ujz.1)
    ENST00000441578(uc002ldq.3 uc010xdg.2) ENST00000332968

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    Inhib. RNA
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    GeneLoc Exon Structure


    Expression
    for RPL17-C18orf32 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    		 See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    UniProtKB/Swiss-Prot: RL17_HUMAN, P18621
    Tissue specificity: Expressed in pancreas, lung, colon, cystic duct, gall bladder, kidney and liver. Expressed at high
    levels in the well differentiated pancreatic tumor cell lines HPAF, COLO 357 and Capan-1, the moderately
    differentiated pancreatic tumor cell lines T3M-4, AsPc-1 and BxPc-3, the poorly differentiated pancreatic tumor cell
    line MIA PaCa-2, and the pancreatic tumor cell lines of undefined differentiation status such as SW979. Expressed at
    lower levels in the poorly differentiated pancreatic tumor cell lines HCG-25 and PANC-1

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    Orthologs
    for RPL17-C18orf32 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL17-C18orf32 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RPL171 60S ribosomal protein L17-like 81.17(n)
    96.05(a)    		   770025  XM_001231653.2  XP_001231654.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RPL176
    		 --
    		 94(a)
    		 1 → many
    		 2(175798-176641)
    zebrafish
    (Danio rerio)    		 Actinopterygii rpl176
    		 ribosomal protein L17
    		 95(a)
    		 1 → many
    		 21(17812615-17882629)
    fruit fly
    (Drosophila melanogaster)    		 Insecta RpL176
    		 Ribosomal protein L17
    		 68(a)
    		 1 → many
    		 X(6635570-6638290)
    worm
    (Caenorhabditis elegans)    		 Secernentea rpl-176
    		 60S ribosomal protein L17
    		 61(a)
    		 1 → many
    		 I(1156580-1157465)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G674306
    AT1G274006
    		 60S ribosomal protein L17-1
    		 64(a)
    63(a)
    		 many ↔ many
    many ↔ many
    		 1(25262159-25263789)
    1(9515135-9516940)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 ribosomal protein L22, putative, expressed
    		 65(a)
    62(a)
    		 many ↔ many
    many ↔ many
    		 9(4389880-4392872)
    8(26403291-26405813)


    ENSEMBL Gene Tree for RPL17-C18orf32 (if available)
    TreeFam Gene Tree for RPL17-C18orf32 (if available) 

    Paralogs
    for RPL17-C18orf32 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL17-C18orf32 gene

    RPL17-C18orf32 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for RPL17-C18orf32
    PGOHUM00000247871 PGOHUM00000259283 PGOHUM00000240885 PGOHUM00000260059


    Genomic Variants
    for RPL17-C18orf32 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for RPL17-C18orf32 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for RPL17-C18orf32 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL17-C18orf32 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with RPL17-C18orf32)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
    3. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    4. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    5. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    7. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)2 Odintsova T.I....Karpova G.G. (2003)

    External Searches for RPL17-C18orf32 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RPL17-C18orf32 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100526842 HGNC: 44661 Ensembl:ENSG00000215472 euGenes: HUgn100526842 ECgene: RPL17-C18orf32
    H-InvDB: RPL17-C18orf32

    Other Databases showing RPL17-C18orf32 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RPL17-C18orf32 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for RPL17-C18orf32 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RPL17-C18orf32 gene:
    Search GeneIP for patents involving RPL17-C18orf32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RPL17-C18orf32 gene

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    About This Section

     
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