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RPL17-C18orf32 Gene

protein-coding   GIFtS: 20
GCID: GC18M047009

RPL17-C18orf32 Readthrough

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RPL17-C18orf32 Readthrough1 2
RPL17-C18orf32 Protein2

External Ids:    HGNC: 446611   Entrez Gene: 1005268422   Ensembl: ENSG000002154727   UniProtKB: J3QS964   UniProtKB: J3QQT24   
UniProtKB: J3KSJ04   UniProtKB: J3KRB34   UniProtKB: J3KRX54   

Export aliases for RPL17-C18orf32 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL17-C18orf32 Gene:
This locus represents naturally occurring read-through transcription between the neighboring RPL17 (ribosomal
protein L17) and C18orf32 (chromosome 18 open reading frame 32) genes. Alternative splicing results in multiple
transcript variants. The encoded isoforms share sequence identity with the RPL17 protein, but they include
frameshifted C-terminal regions derived from the downstream gene exons. (provided by RefSeq, Dec 2010)

GeneCards Summary for RPL17-C18orf32 Gene:
RPL17-C18orf32 (RPL17-C18orf32 readthrough) is a protein-coding gene. Diseases associated with RPL17-C18orf32 include influenza, and pancreatitis. An important paralog of this gene is RPL17.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for RPL17-C18orf32
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL17-C18orf32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21.1

RPL17-C18orf32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL17-C18orf32 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M047009:  view genomic region     (about GC identifiers)

Start:
47,007,548 bp from pter      End:
47,018,935 bp from pter
Size:
11,388 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/TrEMBL: J3QS96 (See protein sequence)
Recommended Name: 60S ribosomal protein L17  
Size: 138 amino acids; 15960 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: J3QQT2 (See protein sequence)

Recommended Name: 60S ribosomal protein L17  
Size: 171 amino acids; 19786 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: J3KSJ0 (See protein sequence)

Recommended Name: 60S ribosomal protein L17  
Size: 56 amino acids; 6505 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: J3KRB3 (See protein sequence)

Recommended Name: 60S ribosomal protein L17  
Size: 106 amino acids; 12193 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: J3KRX5 (See protein sequence)

Recommended Name: 60S ribosomal protein L17  
Size: 174 amino acids; 20170 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

Explore proteomics data for RPL17-C18orf32 at MOPED


See RPL17-C18orf32 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001186284.1  NP_001186285.1  

ENSEMBL proteins: 
 ENSP00000463379   ENSP00000352143   ENSP00000463338  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR001063 Ribosomal_L22
 IPR005721 Ribosomal_L22/L17_euk/arc
 IPR018260 Ribosomal_L22/L17_CS

Graphical View of Domain Structure for InterPro Entry J3QS96
Graphical View of Domain Structure for InterPro Entry J3QQT2
Graphical View of Domain Structure for InterPro Entry J3KSJ0
Graphical View of Domain Structure for InterPro Entry J3KRB3
Graphical View of Domain Structure for InterPro Entry J3KRX5

ProtoNet protein and cluster: J3QS96

UniProtKB/TrEMBL: J3QS96
Similarity: Belongs to the ribosomal protein L22P family

UniProtKB/TrEMBL: J3QQT2
Similarity: Belongs to the ribosomal protein L22P family

UniProtKB/TrEMBL: J3KSJ0
Similarity: Belongs to the ribosomal protein L22P family

UniProtKB/TrEMBL: J3KRB3
Similarity: Belongs to the ribosomal protein L22P family

UniProtKB/TrEMBL: J3KRX5
Similarity: Belongs to the ribosomal protein L22P family


RPL17-C18orf32 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003735structural constituent of ribosome ----
     
RPL17-C18orf32 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005829cytosol ----
GO:0005840ribosome ----
GO:0015934large ribosomal subunit ----
GO:0022625cytosolic large ribosomal subunit ----

RPL17-C18orf32 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RPL17-C18orf32 About    
See pathways by source

SuperPathContained pathways About
1CFTR translational fidelity class I mutations
Cytoplasmic Ribosomal Proteins0.60


1 BioSystems Pathway for RPL17-C18orf32
    Cytoplasmic Ribosomal Proteins


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Interactions:

    Search GeneGlobe Interaction Network for RPL17-C18orf32

Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ----
GO:0006412translation ----
GO:0006413translational initiation ----
GO:0006414translational elongation ----
GO:0006415translational termination ----

RPL17-C18orf32 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for RPL17-C18orf32



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for RPL17-C18orf32 gene (2 alternative transcripts): 
NM_001199355.1  NM_001199356.1  

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000584895(uc002ldm.2 uc021ujt.1) ENST00000332968 ENST00000577910

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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

RPL17-C18orf32 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RPL17-C18orf32 Protein Expression
    Custom PCR Arrays for RPL17-C18orf32
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL17-C18orf32 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gm101665
Gm103621
predicted pseudogene 101665
predicted gene 103621
89.22(n)1
97.06(a)1
  7 (21.88 cM)5
1000409291  XM_006521611.11  XP_006521674.11 
 361182745 
chicken
(Gallus gallus)
Aves --
--
Uncharacterized protein
92(a)
92(a)
many ↔ many
many ↔ many
AADN03018141.1(1750-5488)
Z(1078185-1081530)
tropical clawed frog
(Xenopus tropicalis)
Amphibia rpl171 ribosomal protein L17 78.34(n)
92.66(a)
  448653  NM_001005078.2  NP_001005078.1 
zebrafish
(Danio rerio)
Actinopterygii rpl171 ribosomal protein L17 77.59(n)
92.09(a)
  336641  NM_212760.1  NP_997925.1 
fruit fly
(Drosophila melanogaster)
Insecta RpL171 Ribosomal protein L17 64.76(n)
69.71(a)
  31613  NM_132118.2  NP_572346.1 
worm
(Caenorhabditis elegans)
Secernentea rpl-171 rpl-17 60.62(n)
67.84(a)
  171692  NM_170799.4  NP_740781.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL17A6
RPL17B6
Protein component of the large (60S) ribosomal sub...
Protein component of the large (60S) ribosomal sub...
52(a)
52(a)
many ↔ many
many ↔ many
XI(109269-110129) YKL180W
X(90786-91657) YJL177W


ENSEMBL Gene Tree for RPL17-C18orf32 (if available)
TreeFam Gene Tree for RPL17-C18orf32 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RPL17-C18orf32 gene
RPL172  

RPL17-C18orf32 for paralogs           About GeneDecksing


4 Pseudogenes.org Pseudogenes for RPL17-C18orf32
PGOHUM00000247871 PGOHUM00000259283 PGOHUM00000240885 PGOHUM00000260059


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing RPL17-C18orf32
DNA2.0 Custom Variant and Variant Library Synthesis for RPL17-C18orf32

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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2 diseases for RPL17-C18orf32:    
About MalaCards
influenza    pancreatitis


RPL17-C18orf32 for disorders           About GeneDecksing


Export disorders for RPL17-C18orf32 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RPL17-C18orf32 gene integrated from 10 sources:
(articles sorted by number of sources associating them with RPL17-C18orf32)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
  2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
  5. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
  6. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
  7. Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. (PubMed id 20639865)1 Xu G....Jaffrey S.R. (Nat. Biotechnol. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100526842 HGNC: 44661 Ensembl:ENSG00000215472 euGenes: HUgn100526842 ECgene: RPL17-C18orf32
H-InvDB: RPL17-C18orf32

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RPL17-C18orf32 gene:
Search GeneIP for patents involving RPL17-C18orf32

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL17-C18orf32
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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