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Aliases for RPL17 Gene

Aliases for RPL17 Gene

  • Ribosomal Protein L17 2 3 5
  • Large Ribosomal Subunit Protein UL22 3 4
  • 60S Ribosomal Protein L23 3 4
  • PD-1 3 4
  • Gene Encoding Putative NFkB Activating Protein 3
  • 60S Ribosomal Protein L17 3
  • RPL23 3
  • L17 3

External Ids for RPL17 Gene

Previous GeneCards Identifiers for RPL17 Gene

  • GC01M109771
  • GC18M046814
  • GC18M045266
  • GC18M045268
  • GC18M047014
  • GC07M002841

Summaries for RPL17 Gene

Entrez Gene Summary for RPL17 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for RPL17 Gene

RPL17 (Ribosomal Protein L17) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome. An important paralog of this gene is RPL17-C18orf32.

UniProtKB/Swiss-Prot for RPL17 Gene

  • Component of the large ribosomal subunit.

Gene Wiki entry for RPL17 Gene

Additional gene information for RPL17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL17 Gene

Genomics for RPL17 Gene

Regulatory Elements for RPL17 Gene

Enhancers for RPL17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H048872 1.9 FANTOM5 Ensembl ENCODE dbSUPER 102.3 +619.0 619002 1 ZNF493 ZFP64 FEZF1 ZNF48 ZNF121 GLIS2 KLF7 ZNF548 FOS ZNF202 RPL17 ENSG00000264269 ENSG00000266696 LOC105372107 ENSG00000265128 ENSG00000263895 LOC101928144 SRP72P1 SMAD2 CTIF
GH18H049019 1.6 Ensembl ENCODE dbSUPER 89.8 +471.4 471367 3 HDGF ARID4B SIN3A YBX1 ZNF2 SLC30A9 ZNF416 ZNF207 ZNF143 FOS RPL17 ENSG00000264269 DYM ZBTB7C LOC105372109
GH18H048901 1.9 FANTOM5 Ensembl ENCODE dbSUPER 38.3 +590.0 590014 2 HDGF FOXA2 MLX ARID4B FEZF1 DMAP1 ZNF2 ZNF416 FOS SP3 RPL17 ENSG00000264269 SMAD2 SMAD7 LOC105372105
GH18H050283 1.4 ENCODE dbSUPER 51.4 -793.6 -793591 4 HDGF FOXA2 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 SMAD4 CXXC1 RPL17 MBD1 ELAC1 MEX3C CFAP53
GH18H050277 1.6 Ensembl ENCODE dbSUPER 43.9 -787.3 -787304 5 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 SMAD4 RPL17 MBD1 CXXC1 MEX3C ELAC1 CFAP53
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL17 on UCSC Golden Path with GeneCards custom track

Promoters for RPL17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000103216 565 1601 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF302 ZNF143

Genomic Location for RPL17 Gene

Chromosome:
18
Start:
49,488,453 bp from pter
End:
49,492,565 bp from pter
Size:
4,113 bases
Orientation:
Minus strand

Genomic View for RPL17 Gene

Genes around RPL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL17 Gene

Proteins for RPL17 Gene

  • Protein details for RPL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18621-RL17_HUMAN
    Recommended name:
    60S ribosomal protein L17
    Protein Accession:
    P18621
    Secondary Accessions:
    • B2R4H3
    • B4E3C2
    • B5ME31
    • J3QL51
    • Q3KQW2
    • Q6NZ54
    • Q7M4M5

    Protein attributes for RPL17 Gene

    Size:
    184 amino acids
    Molecular mass:
    21397 Da
    Quaternary structure:
    • Component of the large ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPL17 Gene

    Alternative splice isoforms for RPL17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPL17 Gene

Post-translational modifications for RPL17 Gene

  • Ubiquitination at Lys13, Lys49, isoforms=2, 355, isoforms=2, 374, isoforms=2, 386, Lys96, and isoforms=2, 3105
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL17 Gene

Domains & Families for RPL17 Gene

Gene Families for RPL17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL17 Gene

Suggested Antigen Peptide Sequences for RPL17 Gene

Graphical View of Domain Structure for InterPro Entry

P18621

UniProtKB/Swiss-Prot:

RL17_HUMAN :
  • Belongs to the universal ribosomal protein uL22 family.
Family:
  • Belongs to the universal ribosomal protein uL22 family.
genes like me logo Genes that share domains with RPL17: view

Function for RPL17 Gene

Molecular function for RPL17 Gene

GENATLAS Biochemistry:
60S ribosomal protein L17
UniProtKB/Swiss-Prot Function:
Component of the large ribosomal subunit.

Phenotypes From GWAS Catalog for RPL17 Gene

Gene Ontology (GO) - Molecular Function for RPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with RPL17: view
genes like me logo Genes that share phenotypes with RPL17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPL17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL17 Gene

Localization for RPL17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL17 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0015934 large ribosomal subunit IEA --
genes like me logo Genes that share ontologies with RPL17: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL17 Gene

Pathways & Interactions for RPL17 Gene

genes like me logo Genes that share pathways with RPL17: view

Pathways by source for RPL17 Gene

1 GeneGo (Thomson Reuters) pathway for RPL17 Gene
1 R&D Systems pathway for RPL17 Gene

Gene Ontology (GO) - Biological Process for RPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,IEA 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL17: view

No data available for SIGNOR curated interactions for RPL17 Gene

Drugs & Compounds for RPL17 Gene

No Compound Related Data Available

Transcripts for RPL17 Gene

Unigene Clusters for RPL17 Gene

Ribosomal protein L17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPL17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RPL17 Gene

No ASD Table

Relevant External Links for RPL17 Gene

GeneLoc Exon Structure for
RPL17
ECgene alternative splicing isoforms for
RPL17

Expression for RPL17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL17 Gene

This gene is overexpressed in Tlymphocyte (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL17 Gene



Protein tissue co-expression partners for RPL17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL17 Gene:

RPL17

SOURCE GeneReport for Unigene cluster for RPL17 Gene:

Hs.293653

mRNA Expression by UniProt/SwissProt for RPL17 Gene:

P18621-RL17_HUMAN
Tissue specificity: Expressed in pancreas, lung, colon, cystic duct, gall bladder, kidney and liver. Expressed at high levels in the well differentiated pancreatic tumor cell lines HPAF, COLO 357 and Capan-1, the moderately differentiated pancreatic tumor cell lines T3M-4, AsPc-1 and BxPc-3, the poorly differentiated pancreatic tumor cell line MIA PaCa-2, and the pancreatic tumor cell lines of undefined differentiation status such as SW979. Expressed at lower levels in the poorly differentiated pancreatic tumor cell lines HCG-25 and PANC-1.

Evidence on tissue expression from TISSUES for RPL17 Gene

  • Blood(4)
  • Lung(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with RPL17: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL17 Gene

Orthologs for RPL17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL17 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
OneToMany
-- 34
  • 99 (a)
OneToMany
-- 34
  • 92 (a)
OneToMany
RPL17 33
  • 91.67 (n)
chimpanzee
(Pan troglodytes)
Mammalia RPL17 34
  • 100 (a)
OneToOne
LOC746201 33
  • 99.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPL17 33 34
  • 92.03 (n)
oppossum
(Monodelphis domestica)
Mammalia RPL17 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia LOC102632403 33
  • 90.22 (n)
Gm5277 34
  • 76 (a)
OneToMany
Rpl17-ps8 16
rat
(Rattus norvegicus)
Mammalia Rpl17 33
  • 90.04 (n)
chicken
(Gallus gallus)
Aves RPL17 34
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL17 34
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8095 33
zebrafish
(Danio rerio)
Actinopterygii rpl17 34
  • 95 (a)
OneToMany
wufa91a06 33
fruit fly
(Drosophila melanogaster)
Insecta CG3203 35
  • 71 (a)
RpL17 34
  • 69 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y48G8AL.8a 35
  • 64 (a)
rpl-17 34
  • 64 (a)
OneToMany
Y48G8AL.8b 35
  • 53 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A06336g 33
  • 57.06 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL17A 33 34
  • 56.24 (n)
RPL17B 34
  • 54 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL137W 33
  • 55.83 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G67430 33
  • 62.63 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1291 33
rice
(Oryza sativa)
Liliopsida Os09g0258600 33
  • 63.23 (n)
Os.9941 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4564 34
  • 77 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl1702 33
  • 59.6 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03703 33
  • 58.74 (n)
Species where no ortholog for RPL17 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL17 Gene

ENSEMBL:
Gene Tree for RPL17 (if available)
TreeFam:
Gene Tree for RPL17 (if available)

Paralogs for RPL17 Gene

Paralogs for RPL17 Gene

(2) SIMAP similar genes for RPL17 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RPL17: view

Variants for RPL17 Gene

Sequence variations from dbSNP and Humsavar for RPL17 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000261753 -- 49,488,623(+) TGGAG(A/G)ACTTC intron-variant, upstream-variant-2KB
rs1000314483 -- 49,488,255(+) TTTTT(A/T)ACAGA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000701955 -- 49,492,482(+) GAGGA(A/G)GAGCG upstream-variant-2KB, utr-variant-5-prime
rs1000813008 -- 49,492,437(+) CGGAG(C/T)AACGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001163459 -- 49,492,530(+) GCGAG(A/T)TTCGT upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL17 Gene

Variant ID Type Subtype PubMed ID
nsv1065279 CNV gain 25217958
nsv2294 CNV deletion 18451855
nsv978629 CNV duplication 23825009

Variation tolerance for RPL17 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL17 Gene

Disorders for RPL17 Gene

Relevant External Links for RPL17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL17

No disorders were found for RPL17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL17 Gene

Publications for RPL17 Gene

  1. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova TI … Karpova GG (Journal of protein chemistry 2003) 3 4 22 60
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 60
  3. A human gene related to the ribosomal protein L23 gene of Halobacterium marismortui. (PMID: 2402465) Mager DL … Freeman JD (Nucleic acids research 1990) 2 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 3 4 60

Products for RPL17 Gene

Sources for RPL17 Gene

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