Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RPL17 Gene

protein-coding   GIFtS: 59
GCID: GC18M047014

Ribosomal Protein L17

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ribosomal Protein L171 2     L172
60S Ribosomal Protein L232 3     RPL232
PD-12 3     Gene Encoding Putative NFkB Activating Protein2
60S Ribosomal Protein L172     

External Ids:    HGNC: 103071   Entrez Gene: 61392   Ensembl: ENSG000002656817   OMIM: 6036615   UniProtKB: P186213   
ORGUL members:         

Export aliases for RPL17 gene to outside databases

Previous GC identifers: GC01M109771 GC18M046814 GC18M045266 GC18M045268 GC07M002841


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RPL17 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family
of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the
encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however,
its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed
pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript
variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32
(chromosome 18 open reading frame 32) gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for RPL17 Gene:
RPL17 (ribosomal protein L17) is a protein-coding gene. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL17-C18orf32.

Gene Wiki entry for RPL17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL17 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   POU2F1a   Sox9   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL17 promoter sequence
   Search Chromatin IP Primers for RPL17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21

RPL17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL17 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M047014:  view genomic region     (about GC identifiers)

Start:
47,014,851 bp from pter      End:
47,018,935 bp from pter
Size:
4,085 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RL17_HUMAN, P18621 (See protein sequence)
Recommended Name: 60S ribosomal protein L17  
Size: 184 amino acids; 21397 Da
1 PDB 3D structure from and Proteopedia for RPL17:
3J3B (3D)    
Secondary accessions: B2R4H3 B4E3C2 B5ME31 J3QL51 Q3KQW2 Q6NZ54 Q7M4M5
Alternative splicing: 3 isoforms:  P18621-1   P18621-2   P18621-3   

Explore the universe of human proteins at neXtProt for RPL17: NX_P18621

Explore proteomics data for RPL17 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys13, Lys49, Lys55, Lys74, Lys86, Lys96, Lys105
  • Modification sites at PhosphoSitePlus

  • See RPL17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_000976.1  NP_001030178.1  NP_001186269.1  NP_001186270.1  NP_001186271.1  NP_001186272.1  NP_001186273.1  NP_001186274.1  

    ENSEMBL proteins: 
     ENSP00000463842   ENSP00000462023   ENSP00000462944   ENSP00000462385   ENSP00000463490  
     ENSP00000462203   ENSP00000463885   ENSP00000464586   ENSP00000461910   ENSP00000462508  
     ENSP00000397798  
    Reactome Protein details: P18621

    RPL17 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RPL17
    OriGene Protein Over-expression Lysate for RPL17
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RPL17
    GenScript Custom Purified and Recombinant Proteins Services for RPL17
    Novus Biologicals RPL17 Protein
    Novus Biologicals RPL17 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPL17

     
    Search eBioscience for Proteins for RPL17 

    RPL17 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for RPL17 (Ribosomal Protein L17)
    OriGene Antibodies for RPL17
    OriGene Custom Antibody Services for RPL17
    Novus Biologicals RPL17 Antibodies
    Abcam antibodies for RPL17
    Cloud-Clone Corp. Antibodies for RPL17
    ThermoFisher Antibody for RPL17
    LSBio Antibodies in human, mouse, rat for RPL17

    RPL17 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RPL17
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RPL17
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RPL17
    Cloud-Clone Corp. CLIAs for RPL17
    Search eBioscience for ELISAs for RPL17 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RPL: L ribosomal proteins

    3 InterPro protein domains:
     IPR001063 Ribosomal_L22
     IPR005721 Ribosomal_L22/L17_euk/arc
     IPR018260 Ribosomal_L22/L17_CS

    Graphical View of Domain Structure for InterPro Entry P18621

    ProtoNet protein and cluster: P18621

    1 Blocks protein domain: IPB001063 Ribosomal protein L22/L17

    UniProtKB/Swiss-Prot: RL17_HUMAN, P18621
    Similarity: Belongs to the ribosomal protein L22P family


    Find genes that share domains with RPL17           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:
         Genatlas biochemistry entry for RPL17:
    60S ribosomal protein L17

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RPL17           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RPL17:
     Increased S DNA content  Nuclear 60S biogenesis defects  Nuclear pre-40S maturation def 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL17
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPL17

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPL17
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPL17

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPL17:
    hsa-mir-124-3p (MIRT022730), hsa-mir-615-3p (MIRT039746), hsa-mir-3200-3p (MIRT052822), hsa-mir-503-5p (MIRT041095), hsa-mir-183-5p (MIRT047046)

    Block miRNA regulation of human, mouse, rat RPL17 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RPL17
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RPL17
    Predesigned siRNA for gene silencing in human, mouse, rat RPL17

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPL17

    Clone
    Products:
         
    OriGene clones in human, mouse for RPL17 (see all 10)
    OriGene ORF clones in mouse, rat for RPL17
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): RPL17 (NM_000985)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL17

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RPL17
    Browse ESI BIO Cell Lines and PureStem Progenitors for RPL17 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL17


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0015934large ribosomal subunit ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325

    Find genes that share ontologies with RPL17           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RPL17 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease


    Find genes that share SuperPaths with RPL17           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL17
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL17
        Cytoplasmic Ribosomal Proteins

    Selected Reactome Pathways for RPL17 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL17):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL17
    Interactions:

        Search GeneGlobe Interaction Network for RPL17

    Selected Interacting proteins for RPL17 (P186212, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 228)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL4P365782, 3MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=2 
    EEF1A1P681042, 3MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 
    RPL11P629132, 3MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 
    RPL13AP404292, 3MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 
    RPL26P612542, 3MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    Find genes that share ontologies with RPL17           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL17 (RL17)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RPL17 gene (8 alternative transcripts): 
    NM_000985.4  NM_001035006.2  NM_001199340.1  NM_001199341.1  NM_001199342.1  NM_001199343.1  NM_001199344.1  NM_001199345.1  

    Unigene Clusters for RPL17:

    Ribosomal protein L17
    Hs.293653  [show with all ESTs], Hs.374588  [show with all ESTs], Hs.485081  [show with all ESTs]
    Unigene Representative Sequences: BU175016, NM_001199355, BE742786
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000584364 ENST00000579408 ENST00000579248(uc021ujv.1 uc021ujw.1 uc021ujx.1 uc021ujy.1)
    ENST00000581373 ENST00000580261 ENST00000580210 ENST00000583637 ENST00000578532
    ENST00000582588 ENST00000581091 ENST00000581741 ENST00000583036 ENST00000580387
    ENST00000582935 ENST00000578528 ENST00000579495 ENST00000582782 ENST00000578966

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RPL17 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RPL17
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RPL17
    Predesigned siRNA for gene silencing in human, mouse, rat RPL17
    Clone
    Products:
         
    OriGene clones in human, mouse for RPL17 (see all 10)
    OriGene ORF clones in mouse, rat for RPL17
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): RPL17 (NM_000985)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL17
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RPL17
    OriGene qSTAR qPCR primer pairs in human, mouse for RPL17
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat RPL17
      QuantiTect SYBR Green Assays in human, mouse, rat RPL17
      QuantiFast Probe-based Assays in human, mouse, rat RPL17

    Additional mRNA sequence: BC106031.1 

    Selected DOTS entries (see all 102):

    DT.121365799  DT.100712154  DT.100803986  DT.101986478  DT.121422775  DT.87001707  DT.100891761  DT.92471690 
    DT.95367963  DT.95349408  DT.95349534  DT.100045644  DT.100807051  DT.92471780  DT.121044830  DT.121104978 
    DT.100891782  DT.92471745  DT.100045639  DT.100891771  DT.121105099  DT.100891760  DT.121044561  DT.121105116 

    Selected AceView cDNA sequences (see all 2299):

    CD513611 CB122226 BU631541 BI831823 CD389661 BU153842 AW193014 BM785522 
    BM745117 BE731936 AU077222 BU737052 BQ680924 CA432982 BU501219 BQ962075 
    D11766 BF917916 BX345024 AA182662 CD389419 BQ059579 BQ083824 BE264434 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RPL17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTCTCCCT
    RPL17 Expression
    About this image


    RPL17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Tonsil (Hematopoietic System)
    RPL17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL17 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.293653 Hs.374588 Hs.485081

    UniProtKB/Swiss-Prot: RL17_HUMAN, P18621
    Tissue specificity: Expressed in pancreas, lung, colon, cystic duct, gall bladder, kidney and liver. Expressed at
    high levels in the well differentiated pancreatic tumor cell lines HPAF, COLO 357 and Capan-1, the moderately
    differentiated pancreatic tumor cell lines T3M-4, AsPc-1 and BxPc-3, the poorly differentiated pancreatic tumor
    cell line MIA PaCa-2, and the pancreatic tumor cell lines of undefined differentiation status such as SW979.
    Expressed at lower levels in the poorly differentiated pancreatic tumor cell lines HCG-25 and PANC-1

        Custom PCR Arrays for RPL17
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RPL17
    OriGene qSTAR qPCR primer pairs in human, mouse for RPL17
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat RPL17
    QuantiTect SYBR Green Assays in human, mouse, rat RPL17
    QuantiFast Probe-based Assays in human, mouse, rat RPL17
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL17 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl171 , 5 ribosomal protein L171, 5 90.22(n)1
    99.46(a)1
      18 (50.96 cM)5
    3191951  NM_001002239.31  NP_001002239.21 
     750004775 
    chicken
    (Gallus gallus)
    Aves RPL176
    ribosomal protein L17
    99(a)
    1 ↔ 1
    JH375357.1(8189-10302)
    lizard
    (Anolis carolinensis)
    Reptilia RPL176
    ribosomal protein L17
    94(a)
    1 ↔ 1
    2(175798-176641)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.80952 Xenopus laevis, similar to ribosomal protein L17, clone more 81.71(n)    BC043971.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa91a062 Danio rerio ribosomal protein L17, mRNA (cDNA clone more 81.79(n)    BC055097.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32033 protein biosynthesis structural
    constituent of more
    71(a)   6C10   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y48G8AL.8a3   -- 64(a)
    (best of 2)
      I(1156599-1157421)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL17A1 RPL17A 56.24(n)
    57.67(a)
      853674   NP_012741.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G674301 AT1G67430 62.63(n)
    67.88(a)
      843063  NM_105410.3  NP_176910.1 
    rice
    (Oryza sativa)
    Liliopsida Os.99412 Oryza sativa (japonica cultivar-group) cDNA clone0 more 70.13(n)    AK072488.1 


    ENSEMBL Gene Tree for RPL17 (if available)
    TreeFam Gene Tree for RPL17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RPL17 gene
    RPL17-C18orf322  
    2 SIMAP similar genes for RPL17 using alignment to 7 protein entries:     RL17_HUMAN (see all proteins):
    LOC202789    LOC402695

    Find genes that share paralogs with RPL17           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RPL17 (see all 57)
    PGOHUM00000262848 PGOHUM00000262849 PGOHUM00000262851 PGOHUM00000262852 PGOHUM00000262864


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RPL17:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2294CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL17
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603661    OMIM disorders: --


    Find genes that share disorders with RPL17           About GenesLikeMe


    Export disorders for RPL17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RPL17 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with RPL17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (Genome Res. 1998)
    2. A human gene related to the ribosomal protein L23 gene of Halobacterium marismortui. (PubMed id 2402465)1, 2, 3 Mager D.L. and Freeman J.D. (Nucleic Acids Res. 1990)
    3. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2, 9 Odintsova T.I....Karpova G.G. (J. Protein Chem. 2003)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    6. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    9. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)
    10. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6139 HGNC: 10307 AceView: RPL17 Ensembl:ENSG00000265681 euGenes: HUgn6139
    ECgene: RPL17 Kegg: 6139 H-InvDB: RPL17

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RPL17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RPL17 gene:
    Search GeneIP for patents involving RPL17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for RPL17 (Ribosomal Protein L17)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RPL17   OriGene RNAi products in human, mouse, rat for RPL17  
     OriGene qPCR primer pairs and template standards for RPL17   OriGene Protein Over-expression Lysate for RPL17  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RPL17  
     OriGene qSTAR qPCR primer pairs in human, mouse for RPL17   OriGene Purified Protein for RPL17  
     OriGene ORF clones in mouse, rat for RPL17   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPL17   OriGene Custom Protein Services for RPL17  

     
     
     Block miRNA regulation of human, mouse, rat RPL17 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RPL17
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL17 Predesigned siRNA for gene silencing in human, mouse, rat RPL17
     QuantiFast Probe-based Assays in human, mouse, rat RPL17 QuantiTect SYBR Green Assays in human, mouse, rat RPL17
     Custom PCR Arrays for RPL17 Search Chromatin IP Primers for RPL17
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat RPL17 Search GeneGlobe Interaction Network for RPL17
     Regulatory tfbs in RPL17 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RPL17 GenScript cDNA clones with any tag delivered in your preferred vector for RPL17
     GenScript Custom Assay Services for RPL17 GenScript Custom overexpressing Cell Line Services for RPL17
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RPL17 (RL17)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RPL17 antibodies
     RPL17 proteins
     RPL17 lysates
     Antibodies for RPL17
     See all of Abcam's Antibodies, Kits and Proteins for RPL17
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RPL17
     Antibodies for RPL17
     ELISAs for RPL17
     CLIAs for RPL17



     Browse ESI BIO Cell Lines and PureStem Progenitors for RPL17
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL17
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RPL17
     SwitchGear Promoter luciferase reporter plasmids for RPL17
     ThermoFisher Antibody for RPL17
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL17
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL17
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPL17
     LSBio Antibodies in human, mouse, rat for RPL17
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RPL17
      Search eBioscience for proteins for RPL17
      Search eBioscience for elisas for RPL17
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RPL17 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4