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Aliases for RPL17 Gene

Aliases for RPL17 Gene

  • Ribosomal Protein L17 2 3 5
  • 60S Ribosomal Protein L23 3 4
  • PD-1 3 4
  • Gene Encoding Putative NFkB Activating Protein 3
  • RPL23 3
  • L17 3

External Ids for RPL17 Gene

Previous GeneCards Identifiers for RPL17 Gene

  • GC01M109771
  • GC18M046814
  • GC18M045266
  • GC18M045268
  • GC18M047014
  • GC07M002841

Summaries for RPL17 Gene

Entrez Gene Summary for RPL17 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for RPL17 Gene

RPL17 (Ribosomal Protein L17) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome. An important paralog of this gene is RPL17-C18orf32.

Gene Wiki entry for RPL17 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL17 Gene

Genomics for RPL17 Gene

Regulatory Elements for RPL17 Gene

Enhancers for RPL17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPL17 on UCSC Golden Path with GeneCards custom track

Promoters for RPL17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL17 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL17 Gene

Chromosome:
18
Start:
49,488,453 bp from pter
End:
49,492,565 bp from pter
Size:
4,113 bases
Orientation:
Minus strand

Genomic View for RPL17 Gene

Genes around RPL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL17 Gene

Proteins for RPL17 Gene

  • Protein details for RPL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18621-RL17_HUMAN
    Recommended name:
    60S ribosomal protein L17
    Protein Accession:
    P18621
    Secondary Accessions:
    • B2R4H3
    • B4E3C2
    • B5ME31
    • J3QL51
    • Q3KQW2
    • Q6NZ54
    • Q7M4M5

    Protein attributes for RPL17 Gene

    Size:
    184 amino acids
    Molecular mass:
    21397 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL17 Gene

    Alternative splice isoforms for RPL17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPL17 Gene

Proteomics data for RPL17 Gene at MOPED

Post-translational modifications for RPL17 Gene

  • Ubiquitination at Lys 13, Lys 49, Lys 55, Lys 74, Lys 86, Lys 96, and Lys 105
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for RPL17 (Ribosomal Protein L17)

No data available for DME Specific Peptides for RPL17 Gene

Domains & Families for RPL17 Gene

Gene Families for RPL17 Gene

Protein Domains for RPL17 Gene

Suggested Antigen Peptide Sequences for RPL17 Gene

Graphical View of Domain Structure for InterPro Entry

P18621

UniProtKB/Swiss-Prot:

RL17_HUMAN :
  • Belongs to the ribosomal protein L22P family.
Family:
  • Belongs to the ribosomal protein L22P family.
genes like me logo Genes that share domains with RPL17: view

Function for RPL17 Gene

Molecular function for RPL17 Gene

GENATLAS Biochemistry:
60S ribosomal protein L17

Gene Ontology (GO) - Molecular Function for RPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with RPL17: view
genes like me logo Genes that share phenotypes with RPL17: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL17 Gene

Localization for RPL17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL17 Gene COMPARTMENTS Subcellular localization image for RPL17 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for RPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL17: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL17 Gene

Pathways & Interactions for RPL17 Gene

genes like me logo Genes that share pathways with RPL17: view

Pathways by source for RPL17 Gene

1 GeneGo (Thomson Reuters) pathway for RPL17 Gene
1 R&D Systems pathway for RPL17 Gene

Gene Ontology (GO) - Biological Process for RPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with RPL17: view

No data available for SIGNOR curated interactions for RPL17 Gene

Drugs & Compounds for RPL17 Gene

No Compound Related Data Available

Transcripts for RPL17 Gene

Unigene Clusters for RPL17 Gene

Ribosomal protein L17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL17 Gene

No ASD Table

Relevant External Links for RPL17 Gene

GeneLoc Exon Structure for
RPL17
ECgene alternative splicing isoforms for
RPL17

Expression for RPL17 Gene

mRNA expression in normal human tissues for RPL17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL17 Gene

This gene is overexpressed in Tlymphocyte (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL17 Gene



SOURCE GeneReport for Unigene cluster for RPL17 Gene Hs.293653

mRNA Expression by UniProt/SwissProt for RPL17 Gene

P18621-RL17_HUMAN
Tissue specificity: Expressed in pancreas, lung, colon, cystic duct, gall bladder, kidney and liver. Expressed at high levels in the well differentiated pancreatic tumor cell lines HPAF, COLO 357 and Capan-1, the moderately differentiated pancreatic tumor cell lines T3M-4, AsPc-1 and BxPc-3, the poorly differentiated pancreatic tumor cell line MIA PaCa-2, and the pancreatic tumor cell lines of undefined differentiation status such as SW979. Expressed at lower levels in the poorly differentiated pancreatic tumor cell lines HCG-25 and PANC-1.
genes like me logo Genes that share expression patterns with RPL17: view

Protein tissue co-expression partners for RPL17 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for RPL17 Gene

Orthologs for RPL17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPL17 35
  • 92.03 (n)
  • 99.46 (a)
RPL17 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL17 35
  • 91.67 (n)
  • 100 (a)
-- 36
  • 92 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rpl17 35
  • 90.22 (n)
  • 99.46 (a)
Rpl17-ps8 16
Gm5277 36
  • 76 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RPL17 35
  • 99.46 (n)
  • 100 (a)
RPL17 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl17 35
  • 90.04 (n)
  • 99.46 (a)
oppossum
(Monodelphis domestica)
Mammalia RPL17 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 99 (a)
OneToMany
chicken
(Gallus gallus)
Aves RPL17 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL17 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8095 35
zebrafish
(Danio rerio)
Actinopterygii wufa91a06 35
rpl17 36
  • 95 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3203 37
  • 71 (a)
RpL17 36
  • 69 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y48G8AL.8a 37
  • 64 (a)
Y48G8AL.8b 37
  • 53 (a)
rpl-17 36
  • 64 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL137W 35
  • 55.83 (n)
  • 58.9 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A06336g 35
  • 57.06 (n)
  • 57.06 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL17A 35
  • 56.24 (n)
  • 57.67 (a)
RPL17A 36
  • 54 (a)
ManyToMany
RPL17B 36
  • 54 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G67430 35
  • 62.63 (n)
  • 67.88 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1291 35
rice
(Oryza sativa)
Liliopsida Os.9941 35
Os09g0258600 35
  • 63.23 (n)
  • 67.88 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03703 35
  • 58.74 (n)
  • 64.02 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl1702 35
  • 59.6 (n)
  • 59.39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4564 36
  • 77 (a)
OneToMany
Species with no ortholog for RPL17:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL17 Gene

ENSEMBL:
Gene Tree for RPL17 (if available)
TreeFam:
Gene Tree for RPL17 (if available)

Paralogs for RPL17 Gene

Paralogs for RPL17 Gene

(2) SIMAP similar genes for RPL17 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RPL17: view

Variants for RPL17 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPL17 Gene

Variant ID Type Subtype PubMed ID
nsv2294 CNV Loss 18451855

Variation tolerance for RPL17 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for RPL17 Gene

Disorders for RPL17 Gene

Relevant External Links for RPL17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL17

No disorders were found for RPL17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL17 Gene

Publications for RPL17 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 67
  2. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova T.I. … Karpova G.G. (J. Protein Chem. 2003) 3 23
  3. A human gene related to the ribosomal protein L23 gene of Halobacterium marismortui. (PMID: 2402465) Mager D.L. … Freeman J.D. (Nucleic Acids Res. 1990) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for RPL17 Gene

Sources for RPL17 Gene

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