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Aliases for RPL15 Gene

Aliases for RPL15 Gene

  • Ribosomal Protein L15 2 3 5
  • EC45 3 4
  • 60S Ribosomal Protein L15 3
  • RPLY10 3
  • RPYL10 3
  • DBA12 3
  • RPL10 3
  • L15 3

External Ids for RPL15 Gene

Previous GeneCards Identifiers for RPL15 Gene

  • GC03M023392
  • GC03P023641
  • GC03P023807
  • GC03P023933

Summaries for RPL15 Gene

Entrez Gene Summary for RPL15 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15E family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Although this gene has been referred to as RPL10, its official symbol is RPL15. This gene has been shown to be overexpressed in some esophageal tumors compared to normal matched tissues. Alternate splicing results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Nov 2011]

GeneCards Summary for RPL15 Gene

RPL15 (Ribosomal Protein L15) is a Protein Coding gene. Diseases associated with RPL15 include Diamond-Blackfan Anemia 12 and Diamond-Blackfan Anemia. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL15 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL15 Gene

Genomics for RPL15 Gene

Regulatory Elements for RPL15 Gene

Enhancers for RPL15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F023875 1.4 Ensembl ENCODE 11.7 -39.6 -39599 2.7 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 RPL24P7 UBE2E1 UBE2E1-AS1 RPL15 NKIRAS1 NR1D2 ARL4AP4 GC03M023860
GH03F023873 1.3 Ensembl ENCODE 11.5 -42.2 -42199 1.5 HDGF PKNOX1 ATF1 ARNT FEZF1 ZNF2 ZNF48 YY1 FOS SP3 RPL15 NKIRAS1 NR1D2 ARL4AP4 GC03M023860
GH03F023864 1.2 Ensembl ENCODE 11.8 -50.8 -50759 2.1 ATF1 ZNF766 GATA2 JUNB TBX21 MEF2D SMARCA4 MYNN GLIS1 NBN RPL15 NKIRAS1 UBE2E1 UBE2E1-AS1 NR1D2 GC03M023860 ARL4AP4
GH03F023856 1.2 Ensembl ENCODE 11.8 -58.3 -58308 4.5 PKNOX1 CBX3 TBL1XR1 WRNIP1 ZNF133 BMI1 RAD21 SCRT2 ZNF143 ETV6 RPL15 NKIRAS1 UBE2E1 UBE2E1-AS1 NR1D2 GC03P023854 GC03M023860
GH03F023958 1.1 Ensembl ENCODE 11.5 +42.6 42598 2.2 PKNOX1 INSM2 ZEB1 ZNF335 ZNF366 SCRT2 FOS ZNF362 CEBPB ZEB2 RPL15 NKIRAS1 NPM1P23
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL15 on UCSC Golden Path with GeneCards custom track

Promoters for RPL15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001359413 655 3201 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for RPL15 Gene

23,916,545 bp from pter
23,923,696 bp from pter
7,152 bases
Plus strand

Genomic View for RPL15 Gene

Genes around RPL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL15 Gene

Proteins for RPL15 Gene

  • Protein details for RPL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L15
    Protein Accession:
    Secondary Accessions:
    • P39030
    • P41051
    • Q5U0C0
    • Q642I1
    • Q6IPX6
    • Q8WYP2
    • Q96C44
    • Q9H2E5

    Protein attributes for RPL15 Gene

    204 amino acids
    Molecular mass:
    24146 Da
    Quaternary structure:
    • Interacts with IFIT1 (via TPR repeats 1-4).
    • Sequence=AAA36583.1; Type=Frameshift; Positions=199; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL15 Gene

    Alternative splice isoforms for RPL15 Gene


neXtProt entry for RPL15 Gene

Post-translational modifications for RPL15 Gene

  • Ubiquitination at Lys 5, Lys 56, Lys 83, Lys 93, Lys 140, Lys 153, Lys 157, and Lys 179
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL15 Gene

Domains & Families for RPL15 Gene

Gene Families for RPL15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L15e family.
  • Belongs to the ribosomal protein L15e family.
genes like me logo Genes that share domains with RPL15: view

Function for RPL15 Gene

Molecular function for RPL15 Gene

GENATLAS Biochemistry:
60S ribosomal protein L15

Gene Ontology (GO) - Molecular Function for RPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9582194
GO:0003735 structural constituent of ribosome NAS,TAS 12962325
GO:0005515 protein binding IPI 21612406
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with RPL15: view
genes like me logo Genes that share phenotypes with RPL15: view

Human Phenotype Ontology for RPL15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL15 Gene

Localization for RPL15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL15 Gene

Membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL15 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0005840 ribosome TAS 9582194
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with RPL15: view

Pathways & Interactions for RPL15 Gene

genes like me logo Genes that share pathways with RPL15: view

Pathways by source for RPL15 Gene

1 KEGG pathway for RPL15 Gene
1 GeneGo (Thomson Reuters) pathway for RPL15 Gene

Gene Ontology (GO) - Biological Process for RPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,TAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL15: view

No data available for SIGNOR curated interactions for RPL15 Gene

Drugs & Compounds for RPL15 Gene

(3) Drugs for RPL15 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL15: view

Transcripts for RPL15 Gene

Unigene Clusters for RPL15 Gene

Ribosomal protein L15:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL15 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for RPL15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL15 Gene

This gene is overexpressed in Ovary (6.5) and Saliva (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL15 Gene

Protein tissue co-expression partners for RPL15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL15 Gene:


SOURCE GeneReport for Unigene cluster for RPL15 Gene:

genes like me logo Genes that share expression patterns with RPL15: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL15 Gene

Orthologs for RPL15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL15 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia RPL15 35
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia RPL15 35
  • 100 (a)
(Pan troglodytes)
Mammalia RPL15 34 35
  • 99.67 (n)
(Canis familiaris)
Mammalia RPL15 34 35
  • 93.14 (n)
(Mus musculus)
Mammalia Rpl15 34 16 35
  • 93.14 (n)
(Rattus norvegicus)
Mammalia Rpl15 34
  • 91.67 (n)
(Bos Taurus)
Mammalia RPL15 34 35
  • 89.54 (n)
(Gallus gallus)
Aves RPL15 34 35
  • 83.17 (n)
(Anolis carolinensis)
Reptilia RPL15 35
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl15 34
  • 81.86 (n)
Str.6192 34
African clawed frog
(Xenopus laevis)
Amphibia rpl15-prov 34
(Danio rerio)
Actinopterygii rpl15 34 35
  • 79.08 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta RL15_ANOGA 34
  • 66.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL15 36 34 35
  • 64.71 (n)
(Caenorhabditis elegans)
Secernentea rpl-15 36 35
  • 76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL15A 35
  • 71 (a)
RPL15B 34 35
  • 60.92 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR214C 34
  • 62.56 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17633g 34
  • 61.74 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16720 34
  • 65.35 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10328 34
(Oryza sativa)
Liliopsida Os05g0274700 34
  • 67 (n)
(Triticum aestivum)
Liliopsida Ta.26531 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7913 35
  • 83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl15 34
  • 65.67 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01776 34
  • 64.53 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10603 34
Species where no ortholog for RPL15 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL15 Gene

Gene Tree for RPL15 (if available)
Gene Tree for RPL15 (if available)

Paralogs for RPL15 Gene

(1) SIMAP similar genes for RPL15 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RPL15: view

No data available for Paralogs for RPL15 Gene

Variants for RPL15 Gene

Sequence variations from dbSNP and Humsavar for RPL15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1057036 -- 23,919,488(+) GCTCC(A/C)CCGTT intron-variant, reference, missense
rs1064252 -- 23,919,428(+) GTTCC(A/C)CCACA intron-variant, reference, missense
rs111230172 -- 23,917,524(+) TCCTG(A/T)GATGT intron-variant, upstream-variant-2KB
rs11129128 -- 23,920,130(+) TAGCA(A/G)TGAAT intron-variant, utr-variant-3-prime
rs111361874 -- 23,916,731(+) GGAGA(C/G)GCGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL15 Gene

Variant ID Type Subtype PubMed ID
nsv966996 CNV duplication 23825009
nsv834638 CNV loss 17160897
nsv1005186 CNV gain 25217958

Variation tolerance for RPL15 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL15 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL15 Gene

Disorders for RPL15 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RPL15 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 12
  • dba12
diamond-blackfan anemia
  • blackfan - diamond syndrome
rpl15-related diamond-blackfan anemia
  • diamond-blackfan anemia 12
macrocytic anemia
  • anemia macrocytic
pierre robin syndrome
  • pierre robin sequence
- elite association - COSMIC cancer census association via MalaCards
Search RPL15 in MalaCards View complete list of genes associated with diseases


  • Diamond-Blackfan anemia 12 (DBA12) [MIM:615550]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:23812780}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPL15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL15: view

No data available for Genatlas for RPL15 Gene

Publications for RPL15 Gene

  1. Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia. (PMID: 23812780) Landowski M. … Gazda H.T. (Hum. Genet. 2013) 3 4 64
  2. A novel interaction between interferon-inducible protein p56 and ribosomal protein L15 in gastric cancer cells. (PMID: 21612406) Hsu Y.A. … Chen B.H. (DNA Cell Biol. 2011) 3 4 64
  3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Cloning and characterization of full-length human ribosomal protein L15 cDNA which was overexpressed in esophageal cancer. (PMID: 11223259) Wang Q. … Liu Z. (Gene 2001) 3 22 64

Products for RPL15 Gene

Sources for RPL15 Gene

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