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RPL15 Gene

protein-coding   GIFtS: 65
GCID: GC03P023960

Ribosomal Protein L15

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein L151 2     L152
EC452 3     RPL102
DBA122 5     RPLY102
60S Ribosomal Protein L152     RPYL102

External Ids:    HGNC: 103061   Entrez Gene: 61382   Ensembl: ENSG000001747487   OMIM: 6041745   UniProtKB: P613133   

Export aliases for RPL15 gene to outside databases

Previous GC identifers: GC03M023392 GC03P023641 GC03P023807 GC03P023933


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL15 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15E family
of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with the yeast
ribosomal protein YL10 gene. Although this gene has been referred to as RPL10, its official symbol is RPL15. This
gene has been shown to be overexpressed in some esophageal tumors compared to normal matched tissues. Alternate
splicing results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are
multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Nov 2011)

GeneCards Summary for RPL15 Gene:
RPL15 (ribosomal protein L15) is a protein-coding gene. Diseases associated with RPL15 include diamond-blackfan anemia 12, and diamond-blackfan anemia 1. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

Gene Wiki entry for RPL15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL15 gene promoter:
         AML1a   NF-kappaB   YY1   C/EBPalpha   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   NF-kappaB1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL15 promoter sequence
   Search Chromatin IP Primers for RPL15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.2   Ensembl cytogenetic band:  3p24.2   HGNC cytogenetic band: 3p24.1

RPL15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL15 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P023960:  view genomic region     (about GC identifiers)

Start:
23,958,036 bp from pter      End:
23,965,183 bp from pter
Size:
7,148 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RL15_HUMAN, P61313 (See protein sequence)
Recommended Name: 60S ribosomal protein L15  
Size: 204 amino acids; 24146 Da
Subunit: Interacts with IFIT1 (via TPR repeats 1-4)
Sequence caution: Sequence=AAA36583.1; Type=Frameshift; Positions=199;
1 PDB 3D structure from and Proteopedia for RPL15:
3J3B (3D)    
Secondary accessions: P39030 P41051 Q5U0C0 Q642I1 Q6IPX6 Q8WYP2 Q96C44 Q9H2E5
Alternative splicing: 2 isoforms:  P61313-1   P61313-2   

Explore the universe of human proteins at neXtProt for RPL15: NX_P61313

Explore proteomics data for RPL15 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys5, Lys56, Lys83, Lys93, Lys140, Lys153, Lys157, Lys179
  • Modification sites at PhosphoSitePlus

  • See RPL15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001240308.1  NP_001240309.1  NP_001240311.1  NP_001240312.1  NP_001240313.1  NP_002939.2  

    ENSEMBL proteins: 
     ENSP00000309334   ENSP00000387925   ENSP00000405590   ENSP00000416692   ENSP00000411176  
     ENSP00000388529   ENSP00000390193   ENSP00000346867   ENSP00000408243   ENSP00000398788  
    Reactome Protein details: P61313

    RPL15 Human Recombinant Protein Products:

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    RPL15 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    4 InterPro protein domains:
     IPR000439 Ribosomal_L15e
     IPR012678 Ribosomal_L23/L15e_core_dom
     IPR020925 Ribosomal_L15e_CS
     IPR024794 Rbsml_L15e_core_dom

    Graphical View of Domain Structure for InterPro Entry P61313

    ProtoNet protein and cluster: P61313

    UniProtKB/Swiss-Prot: RL15_HUMAN, P61313
    Similarity: Belongs to the ribosomal protein L15e family


    RPL15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPL15:
    60S ribosomal protein L15

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS9582194
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    RPL15 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RPL15:
     Decreased viability of wild-ty  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL15
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPL15

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPL15:
    hsa-mir-342-3p (MIRT043689), hsa-mir-503-5p (MIRT041107), hsa-mir-221-5p (MIRT038663), hsa-mir-100-5p (MIRT048511), hsa-mir-7-5p (MIRT025638), hsa-mir-10a-5p (MIRT047531), hsa-mir-149-5p (MIRT045391), hsa-mir-615-3p (MIRT039682), hsa-mir-221-3p (MIRT046869), hsa-mir-20a-3p (MIRT038970), hsa-mir-92a-3p (MIRT049215)

    Block miRNA regulation of human, mouse, rat RPL15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPL15 (see all 31):
    hsa-miR-320a hsa-miR-875-3p hsa-miR-676 hsa-miR-4318 hsa-miR-137 hsa-miR-520d-5p hsa-miR-767-5p hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidRPL15 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RPL15
    Predesigned siRNA for gene silencing in human, mouse, rat RPL15

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for RPL15 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPL15 (NM_002948)
    Sino Biological Human cDNA Clone for RPL15
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL15

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RPL15 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005840ribosome TAS9582194
    GO:0022625cytosolic large ribosomal subunit IDA12962325

    RPL15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPL15 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL15
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL15
        Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPL15 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL15):
        Ribosome


    RPL15 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL15
    Interactions:

        Search GeneGlobe Interaction Network for RPL15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL15 (P613132, 3 ENSP000003093344) via UniProtKB, MINT, STRING, and/or I2D (see all 475)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPL15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL15 (RL15)

    3 DrugBank Compounds for RPL15    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ANISOMYCIN-- --target--10592235
    Alpha-Hydroxy-Beta-Phenyl-Propionic Acid-- --target--10592235
    PUROMYCIN-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPL15 gene (6 alternative transcripts): 
    NM_001253379.1  NM_001253380.1  NM_001253382.1  NM_001253383.1  NM_001253384.1  NM_002948.3  

    Unigene Cluster for RPL15:

    Ribosomal protein L15
    Hs.381219  [show with all ESTs]
    Unigene Representative Sequence: NM_001253384
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307839(uc011awi.2 uc011awj.2 uc003ccr.3 uc003ccn.3)
    ENST00000422218 ENST00000434031 ENST00000413699(uc003ccp.3 uc003ccq.3)
    ENST00000412097 ENST00000415719 ENST00000490223 ENST00000465786 ENST00000435882
    ENST00000354811 ENST00000436146(uc021wub.1) ENST00000456530(uc003cco.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat RPL15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPL15 (see all 31):
    hsa-miR-320a hsa-miR-875-3p hsa-miR-676 hsa-miR-4318 hsa-miR-137 hsa-miR-520d-5p hsa-miR-767-5p hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidRPL15 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RPL15
    Clone
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    GenScript: all cDNA clones in your preferred vector: RPL15 (NM_002948)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL15
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      QuantiTect SYBR Green Assays in human, mouse, rat RPL15
      QuantiFast Probe-based Assays in human, mouse, rat RPL15

    Additional mRNA sequence: 

    AF279903.1 AF283772.2 AK055501.1 AK098795.1 AK129815.1 AK290694.1 AK292000.1 AK293709.1 
    AK297091.1 AY347528.1 BC014837.1 BC068198.1 BC070328.1 BC071672.1 BC081565.1 BT019672.1 
    L25899.1 

    Selected DOTS entries (see all 184):

    DT.100863157  DT.95289679  DT.92473008  DT.100856254  DT.92325056  DT.92473116  DT.100863344  DT.100727338 
    DT.100727317  DT.100727306  DT.100727372  DT.87008050  DT.100727367  DT.95346088  DT.92473053  DT.95346189 
    DT.100727364  DT.320889  DT.100862666  DT.120902037  DT.100727359  DT.100859308  DT.100863287  DT.92473067 

    Selected AceView cDNA sequences (see all 4026):

    CR593841 CR622675 AI129372 N98894 BI438628 AI679671 BU145832 BU172513 
    T34488 BI861767 BM976405 AI174573 BM423340 CA941059 CR598750 BM907413 
    AA330064 CA866998 BU616316 BQ233351 CF127801 BP376770 CR595665 BX438652 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RPL15    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
    SP1:                          -                           
    SP2:              -           -                           
    SP3:                          -                           
    SP4:        -     -                                       


    ECgene alternative splicing isoforms for RPL15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPL15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTTAACCA
    RPL15 Expression
    About this image


    RPL15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
    RPL15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.381219
        Custom PCR Arrays for RPL15
    Primer
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    OriGene qPCR primer pairs and template standards for RPL15
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL15 gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl151 , 5 ribosomal protein L151, 5 93.14(n)1
    100(a)1
      14 (7.08 cM)5
    664801  NM_025586.31  NP_079862.11 
     182678235 
    chicken
    (Gallus gallus)
    Aves RPL151 ribosomal protein L15 83.17(n)
    99.51(a)
      428442  XM_426002.4  XP_426002.2 
    lizard
    (Anolis carolinensis)
    Reptilia RPL156
    ribosomal protein L15
    99(a)
    1 ↔ 1
    GL343357.1(660504-667605)
    African clawed frog
    (Xenopus laevis)
    Amphibia rpl15-prov2 ribosomal protein L15 82.41(n)    BC046569.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM183678.12   -- 78.77(n)    BM183678.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL151 , 3 protein biosynthesis structural
    constituent of more3
    Ribosomal protein L151
    74(a)3
    64.71(n)1
    74.02(a)1
      33549181  NM_001015155.31  NP_001015155.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-153 60S ribosomal protein L15 76(a)   IV(653489-654669)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL15B1 RPL15B 60.92(n)
    71.92(a)
      855150   NP_013840.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G167201 AT4G16720 65.35(n)
    70.44(a)
      827375  NM_117773.3  NP_193405.1 
    rice
    (Oryza sativa)
    Liliopsida CA754173.12   -- 76.25(n)    CA754173.1 


    ENSEMBL Gene Tree for RPL15 (if available)
    TreeFam Gene Tree for RPL15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPL15 gene
    1 SIMAP similar gene for RPL15 using alignment to 5 protein entries:     RL15_HUMAN (see all proteins):
    LOC136321

    RPL15 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPL15 (see all 31)
    PGOHUM00000251261 PGOHUM00000238834 PGOHUM00000238929 PGOHUM00000250391 PGOHUM00000242795


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPL15 (see all 152)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30847091,2
    C--23958211(+) CAGCGC/TAGCGC 1 -- us2k10--------
    rs38425791,2
    C--23958213(-) CCGCG-/T/TC  
      TCCGCG
    CTGCG
    1 -- us2k10--------
    rs1495807561,2
    --23960543(+) GATAGG/TCTAGG 6 -- int10--------
    rs781343391,2
    C--23960660(+) AGATTG/AACCTT 6 -- int11Minor allele frequency- A:0.01EA 120
    rs1512186321,2
    C--23960758(+) ACATAC/TAAATT 11 Y syn1 int11Minor allele frequency- T:0.00NA 4176
    rs1817900841,2
    C--23960872(+) CTGACA/GTCTGC 11 T syn1 int10--------
    rs39517061,2
    --23960935(+) GGTGGC/TTCTCG 11 G syn1 int1 ese30--------
    rs40246261,2
    --23961020(+) CATACC/TTAATA 6 -- ut31 int1 ese30--------
    rs1847862131,2
    --23961178(+) ATAAGA/TTAAAC 6 -- ut31 int10--------
    rs726270831,2
    C,F--23961217(+) GAGTTG/ATATGT 6 -- ut31 int12Minor allele frequency- A:0.04WA NS 268

    HapMap Linkage Disequilibrium report for RPL15 (23958036 - 23965183 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RPL15: --
    Human Gene Mutation Database (HGMD): RPL15
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL15
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604174   
    OMIM disorders: 615550  
    13 diseases for RPL15:    
    About MalaCards
    diamond-blackfan anemia 12    diamond-blackfan anemia 1    esophagitis    folliculitis
    actinic keratosis    diamond-blackfan anemia    treacher collins syndrome    keratosis
    papillary thyroid carcinoma    esophageal cancer    influenza    thyroiditis
    malaria


    RPL15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RPL15
    Human Genome Epidemiology (HuGE) Navigator: RPL15 (1 document)

    Export disorders for RPL15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPL15 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with RPL15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel interaction between interferon-inducible protein p56 and ribosomal protein L15 in gastric cancer cells. (PubMed id 21612406)1, 2 Hsu Y.A.... Chen B.H. (DNA Cell Biol. 2011)
    2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 3 Kenmochi N.... Page D.C. (Genome Res. 1998)
    5. Cloning and characterization of full-length human ribosomal protein L15 cDNA which was overexpressed in esophageal cancer. (PubMed id 11223259)1, 9 Wang Q....Liu Z. (Gene 2001)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)
    8. Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (RNA 2013)
    9. Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia. (PubMed id 23812780)1 Landowski M....Gazda H.T. (Hum. Genet. 2013)
    10. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6138 HGNC: 10306 AceView: RPL15 Ensembl:ENSG00000174748 euGenes: HUgn6138
    ECgene: RPL15 Kegg: 6138 H-InvDB: RPL15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPL15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPL15 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPL15 gene:
    Search GeneIP for patents involving RPL15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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