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Aliases for RPL15 Gene

Aliases for RPL15 Gene

  • Ribosomal Protein L15 2 3
  • DBA12 3 6
  • EC45 3 4
  • 60S Ribosomal Protein L15 3
  • RPLY10 3
  • RPYL10 3
  • RPL10 3
  • L15 3

External Ids for RPL15 Gene

Summaries for RPL15 Gene

Entrez Gene Summary for RPL15 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15E family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Although this gene has been referred to as RPL10, its official symbol is RPL15. This gene has been shown to be overexpressed in some esophageal tumors compared to normal matched tissues. Alternate splicing results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Nov 2011]

GeneCards Summary for RPL15 Gene

RPL15 (Ribosomal Protein L15) is a Protein Coding gene. Diseases associated with RPL15 include diamond-blackfan anemia 12 and diamond-blackfan anemia. Among its related pathways are Disease and Adhesion. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL15 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL15 Gene

Genomics for RPL15 Gene

Genomic Location for RPL15 Gene

Start:
23,916,545 bp from pter
End:
23,923,696 bp from pter
Size:
7,152 bases
Orientation:
Plus strand

Genomic View for RPL15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL15 Gene

Proteins for RPL15 Gene

  • Protein details for RPL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61313-RL15_HUMAN
    Recommended name:
    60S ribosomal protein L15
    Protein Accession:
    P61313
    Secondary Accessions:
    • P39030
    • P41051
    • Q5U0C0
    • Q642I1
    • Q6IPX6
    • Q8WYP2
    • Q96C44
    • Q9H2E5

    Protein attributes for RPL15 Gene

    Size:
    204 amino acids
    Molecular mass:
    24146 Da
    Quaternary structure:
    • Interacts with IFIT1 (via TPR repeats 1-4).
    SequenceCaution:
    • Sequence=AAA36583.1; Type=Frameshift; Positions=199; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL15 Gene

    Alternative splice isoforms for RPL15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPL15 Gene

Proteomics data for RPL15 Gene at MOPED

Post-translational modifications for RPL15 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys5, Lys56, Lys83, Lys93, Lys140, Lys153, Lys157, and Lys179

No data available for DME Specific Peptides for RPL15 Gene

Domains for RPL15 Gene

Gene Families for RPL15 Gene

HGNC:
  • RPL :L ribosomal proteins

Protein Domains for RPL15 Gene

UniProtKB/Swiss-Prot:

RL15_HUMAN
Family:
  • Belongs to the ribosomal protein L15e family.:
    • P61313
genes like me logo Genes that share domains with RPL15: view

Function for RPL15 Gene

Molecular function for RPL15 Gene

GENATLAS Biochemistry: 60S ribosomal protein L15

Gene Ontology (GO) - Molecular Function for RPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9582194
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 21612406
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL15: view

Phenotypes for RPL15 Gene

genes like me logo Genes that share phenotypes with RPL15: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL15 Gene

Localization for RPL15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL15 Gene COMPARTMENTS Subcellular localization image for RPL15 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0005840 ribosome TAS 9582194
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
genes like me logo Genes that share ontologies with RPL15: view

Pathways for RPL15 Gene

genes like me logo Genes that share pathways with RPL15: view

Pathways by source for RPL15 Gene

1 R&D Systems pathway for RPL15 Gene
1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPL15 Gene
1 Qiagen pathway for RPL15 Gene
1 Cell Signaling Technology pathway for RPL15 Gene

Gene Ontology (GO) - Biological Process for RPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL15: view

Compounds for RPL15 Gene

(3) Drugbank Compounds for RPL15 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
target
ANISOMYCIN
target
PUROMYCIN
target
genes like me logo Genes that share compounds with RPL15: view

Transcripts for RPL15 Gene

Unigene Clusters for RPL15 Gene

Ribosomal protein L15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL15 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for RPL15 Gene

GeneLoc Exon Structure for
RPL15
ECgene alternative splicing isoforms for
RPL15

Expression for RPL15 Gene

mRNA expression in normal human tissues for RPL15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL15 Gene

SOURCE GeneReport for Unigene cluster for RPL15 Gene Hs.381219

genes like me logo Genes that share expressions with RPL15: view

Orthologs for RPL15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL15 36
  • 99.67 (n)
  • 100 (a)
RPL15 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPL15 36
  • 89.54 (n)
  • 100 (a)
RPL15 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL15 36
  • 93.14 (n)
  • 100 (a)
RPL15 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl15 36
  • 93.14 (n)
  • 100 (a)
Rpl15 16
Rpl15 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPL15 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL15 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl15 36
  • 91.67 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPL15 36
  • 83.17 (n)
  • 99.51 (a)
RPL15 37
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL15 37
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rpl15-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl15 36
  • 81.86 (n)
  • 93.63 (a)
Str.6192 36
zebrafish
(Danio rerio)
Actinopterygii rpl15 36
  • 79.08 (n)
  • 95.59 (a)
rpl15 37
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta RL15_ANOGA 36
  • 66.5 (n)
  • 74.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL15 36
  • 64.71 (n)
  • 74.02 (a)
RpL15 37
  • 74 (a)
OneToOne
RpL15 38
  • 74 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-15 37
  • 76 (a)
OneToOne
rpl-15 38
  • 76 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR214C 36
  • 62.56 (n)
  • 70.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL15A 37
  • 71 (a)
OneToMany
RPL15B 36
  • 60.92 (n)
  • 71.92 (a)
RPL15B 37
  • 71 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17633g 36
  • 61.74 (n)
  • 71.92 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10328 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16720 36
  • 65.35 (n)
  • 70.44 (a)
rice
(Oryza sativa)
Liliopsida Os05g0274700 36
  • 67 (n)
  • 72.41 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.26531 36
bread mold
(Neurospora crassa)
Ascomycetes NCU01776 36
  • 64.53 (n)
  • 72.91 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl15 36
  • 65.67 (n)
  • 72.64 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10603 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7913 37
  • 83 (a)
OneToOne
Species with no ortholog for RPL15:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL15 Gene

ENSEMBL:
Gene Tree for RPL15 (if available)
TreeFam:
Gene Tree for RPL15 (if available)

Paralogs for RPL15 Gene

Selected SIMAP similar genes for RPL15 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RPL15: view

No data available for Paralogs for RPL15 Gene

Variants for RPL15 Gene

Sequence variations from dbSNP and Humsavar for RPL15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1057036 -- 23,919,488(+) GCTCC(A/C)CCGTT reference, missense, intron-variant
rs1064252 -- 23,919,428(+) GTTCC(A/C)CCACA reference, missense, intron-variant
rs1133926 -- 23,920,271(+) GGGGG(A/G)AAGTA utr-variant-3-prime, intron-variant
rs1134960 -- 23,920,745(+) TTGAG(A/C)CCTAA utr-variant-3-prime, intron-variant
rs1135002 -- 23,920,759(+) TCTTC(A/C)CAAAA utr-variant-3-prime, intron-variant

Relevant External Links for RPL15 Gene

HapMap Linkage Disequilibrium report
RPL15
Human Gene Mutation Database (HGMD)
RPL15

No data available for Structural Variations from Database of Genomic Variants (DGV) for RPL15 Gene

Disorders for RPL15 Gene

(1) OMIM Diseases for RPL15 Gene (604174)

UniProtKB/Swiss-Prot

RL15_HUMAN
  • Diamond-Blackfan anemia 12 (DBA12) [MIM:615550]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:23812780}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPL15

Genetic Association Database (GAD)
RPL15
Human Genome Epidemiology (HuGE) Navigator
RPL15
genes like me logo Genes that share disorders with RPL15: view

Publications for RPL15 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A novel interaction between interferon-inducible protein p56 and ribosomal protein L15 in gastric cancer cells. (PMID: 21612406) Hsu Y.A. … Chen B.H. (DNA Cell Biol. 2011) 3 4
  4. Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia. (PMID: 23812780) Landowski M. … Gazda H.T. (Hum. Genet. 2013) 3 4
  5. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 49

Products for RPL15 Gene

Sources for RPL15 Gene

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