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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPL15 Gene

protein-coding GIFtS: 61
GCID: GC03P023933

ribosomal protein L15

Explore 14 diseases affiliated with
RPL15 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribosomal Protein L15¹ ²		RPLY10¹ ²
EC45¹ ² ³		RPYL10¹ ²
L15¹ ²		60S Ribosomal Protein L15²
RPL10¹ ²

External Ids:	HGNC: 10306¹	Entrez Gene: 6138²	Ensembl: ENSG00000174748⁷	OMIM: 604174⁵	UniProtKB: P61313³

Export aliases for RPL15 gene to outside databases

Previous GC identifers: GC03M023392 GC03P023641 GC03P023807

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL15:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.

Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene

encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15E family of

ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with the yeast ribosomal

protein YL10 gene. Although this gene has been referred to as RPL10, its official symbol is RPL15. This gene has been

shown to be overexpressed in some esophageal tumors compared to normal matched tissues. Alternate splicing results in

multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed

pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Nov 2011)

Gene Wiki entry for RPL15

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPL15 gene promoter:
AML1a NF-kappaB YY1 C/EBPalpha POU2F1 POU2F1a FOXJ2 (long isoform) FOXJ2 NF-kappaB1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPL15 promoter sequence

Search SABiosciences Chromatin IP Primers for RPL15

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL15

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.2 Ensembl cytogenetic band: 3p24.2 HGNC cytogenetic band: 3p24.1

RPL15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL15 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P023933: view genomic region (about GC identifiers)

Start:	23,958,036 bp from pter	End:	23,965,183 bp from pter
Size:	7,148 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RL15_HUMAN, P61313 (See protein sequence)

Recommended Name: 60S ribosomal protein L15

Size: 204 amino acids; 24146 Da

Subunit: Interacts with IFIT1 (via TPR repeats 1-4)

Sequence caution: Sequence=AAA36583.1; Type=Frameshift; Positions=199;

Secondary accessions: P39030 P41051 Q5U0C0 Q642I1 Q6IPX6 Q8WYP2 Q96C44 Q9H2E5

Alternative splicing: 2 isoforms: P61313-1 P61313-2

Explore the universe of human proteins at neXtProt for RPL15: NX_P61313

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P61313

RPL15 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001240308.1 NP_001240309.1 NP_001240311.1 NP_001240312.1 NP_001240313.1 NP_002939.2

ENSEMBL proteins:

ENSP00000309334 ENSP00000387925 ENSP00000405590 ENSP00000416692 ENSP00000411176

ENSP00000388529 ENSP00000390193 ENSP00000346867 ENSP00000408243 ENSP00000398788

Reactome Protein details: P61313
Human Recombinant Protein Products:

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	Novus Biologicals RPL15 Proteins Novus Biologicals RPL15 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RPL15

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005840	ribosome	TAS	9582194
GO:0022625	cytosolic large ribosomal subunit	IDA	12962325

RPL15 for ontologies About GeneDecksing

RPL15 Antibody Products:

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	Uscn ELISAs and CLIAs for RPL15

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPL15 for domains About GeneDecksing

4 InterPro domains/families:

IPR000439 Ribosomal_L15e

IPR012678 Ribosomal_L23/L15e_core_dom

IPR020925 Ribosomal_L15e_CS

IPR024794 Rbsml_L15e_core_dom

Graphical View of Domain Structure for InterPro Entry P61313

ProtoNet protein and cluster: P61313

UniProtKB/Swiss-Prot: RL15_HUMAN, P61313

Similarity: Belongs to the ribosomal protein L15e family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for RPL15:

60S ribosomal protein L15

miRNA Products:		OriGene 3'-UTR Clone: RPL15 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPL15
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate RPL15 (see all 31):
		hsa-miR-320a hsa-miR-875-3p hsa-miR-676 hsa-miR-4318 hsa-miR-137 hsa-miR-520d-5p hsa-miR-767-5p hsa-miR-25

		SwitchGear 3'UTR luciferase reporter plasmid: RPL15 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RPL15

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		GenScript: all cDNA clones in your preferred vector: RPL15 (NM_002948)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RPL15
		Search LifeMap BioReagents cell lines for RPL15

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL15

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	TAS	9582194
GO:0003735	structural constituent of ribosome	NAS	12962325
GO:0005515	protein binding	IPI	--

RPL15 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for RPL15:

Decreased viability of wild-ty

Increased S DNA content

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of PB1-F2

8/26 pathways (see all 26)
Viral Protein Synthesis	1.00	Cytoplasmic Ribosomal Proteins	0.86
Viral mRNA Translation	1.00	CFTR translational fidelity (class I mutations)	0.83
Influenza Viral RNA Transcription and Replication	1.00	SMG6 Cleaves mRNA with Premature Termination Codon	0.80
Synthesis of nascent polypeptide containing signal sequence	1.00	L13a-mediated translational silencing of Ceruloplasmin expression	0.79

Metabolism of mRNA

Metabolism of mRNA

1.00

Metabolism of RNA

0.92

Disease

Disease

1.00

Generic Transcription Pathway

Gene Expression

0.46

Asparagine N-linked glycosylation

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for RPL15

CFTR translational fidelity (class I mutations)

1 BioSystems Pathway for RPL15

Cytoplasmic Ribosomal Proteins

5/28 Reactome Pathways for RPL15 (see all 28)

	Nonsense Mediated Decay Independent of the Exon Junction Complex
	Nonsense-Mediated Decay
	Translation
	SRP-dependent cotranslational protein targeting to membrane
	Eukaryotic Translation Initiation

1 Kegg Pathway (Kegg details for RPL15):

Ribosome

RPL15 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RPL15

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/404 Interacting proteins for RPL15 (P61313^{2, 3} ENSP00000309334⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 404)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=2
HIST1H4B	P62805³	I2D: score=2
HIST1H4C	P62805³	I2D: score=2
HIST1H4D	P62805³	I2D: score=2
HIST1H4E	P62805³	I2D: score=2

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	--
GO:0006412	translation	TAS	--
GO:0006413	translational initiation	TAS	--
GO:0006414	translational elongation	TAS	--
GO:0006415	translational termination	TAS	--

RPL15 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RPL15

3 DrugBank Compounds for RPL15 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
ANISOMYCIN	--	--	target	--	10592235
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid	--	--	target	--	10592235
PUROMYCIN	--	--	target	--	10592235

Search CenterWatch for drugs/clinical trials and news about RPL15 / RL15

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RPL15 gene (6 alternative transcripts):

NM_001253379.1 NM_001253380.1 NM_001253382.1 NM_001253383.1 NM_001253384.1 NM_002948.3

Unigene Cluster for RPL15:

Ribosomal protein L15

Hs.381219 [show with all ESTs]

Unigene Representative Sequence: NM_001253384

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000307839(uc011awi.2 uc011awj.2 uc003ccr.3 uc003ccn.3)

ENST00000422218 ENST00000434031 ENST00000413699(uc003ccp.3 uc003ccq.3)

ENST00000412097 ENST00000415719 ENST00000490223 ENST00000465786 ENST00000435882

ENST00000354811 ENST00000436146(uc021wub.1) ENST00000456530(uc003cco.3)

miRNA Products:		OriGene 3'-UTR Clone: RPL15 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPL15
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate RPL15 (see all 31):
		hsa-miR-320a hsa-miR-875-3p hsa-miR-676 hsa-miR-4318 hsa-miR-137 hsa-miR-520d-5p hsa-miR-767-5p hsa-miR-25

		SwitchGear 3'UTR luciferase reporter plasmid: RPL15 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: RPL15 (NM_002948)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL15
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL15
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL15

Additional cDNA sequence:

AF279903.1 AF283772.2 AK055501.1 AK098795.1 AK129815.1 AK290694.1 AK292000.1 AK293709.1

AK297091.1 AY347528.1 BC014837.1 BC068198.1 BC070328.1 BC071672.1 BC081565.1 BT019672.1

L25899.1

24/196 DOTS entries (see all 196):

DT.100863157 DT.95289679 DT.92473008 DT.100856254 DT.100727317 DT.100863344 DT.92473116 DT.92325056

DT.100727338 DT.87008050 DT.100727306 DT.100727372 DT.92473053 DT.100727367 DT.95346088 DT.95346189

DT.100727364 DT.320889 DT.100862666 DT.120902037 DT.100851073 DT.100727359 DT.100859308 DT.100863287

24/4026 AceView cDNA sequences (see all 4026):

AJ713561 AI816303 AA314932 AI066724 BG926644 CR611630 BF811162 AA112099

CR613287 AI659912 AA605228 BQ213448 BX407084 BU734890 CD106268 BU618945

BM455940 BX336463 BF115454 BU789174 BG700915 BU166220 BU681731 BM781483

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for RPL15 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b
SP1:									-
SP2:					-				-
SP3:									-
SP4:			-		-

ECgene alternative splicing isoforms for RPL15

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPL15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTTAACCA

About this image

RPL15 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Adipose

Interscapular Brown Adipose Depot

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RPL15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPL15

SOURCE GeneReport for Unigene cluster: Hs.381219

SABiosciences Custom PCR Arrays for RPL15

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL15

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL15

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL15 gene from 10/42 species (see all 42) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rpl15^{1 , 5}	ribosomal protein L15^{1, 5}	93.14(n)¹ 100(a)¹		14 (7.08 cM)⁵ 66480¹ NM_025586.3¹ NP_079862.1¹ 18267823⁵
chicken (Gallus gallus)	Aves	RPL15¹	ribosomal protein L15	83.17(n) 99.51(a)		428442 XM_426002.3 XP_426002.2
lizard (Anolis carolinensis)	Reptilia	RPL15⁶	--	99(a)	1 ↔ 1	GL343357.1(662951-665018)
African clawed frog (Xenopus laevis)	Amphibia	rpl15-prov²	ribosomal protein L15	82.41(n)		BC046569.1
zebrafish (Danio rerio)	Actinopterygii	BM183678.1²	--	78.77(n)		BM183678.1
fruit fly (Drosophila melanogaster)	Insecta	RpL15^{1 , 3}	protein biosynthesis structural constituent of more³ Ribosomal protein L15¹	74(a)³ 64.71(n)¹ 74.02(a)¹		3354918¹ NM_001015155.3¹ NP_001015155.1¹
worm (Caenorhabditis elegans)	Secernentea	rpl-15^{1 , 3}	60S ribosomal protein L15³ Protein RPL-15¹	76(a)³ 65.2(n)¹ 76.47(a)¹		IV(653489-654669)³ 176891¹ NM_067563.3¹ NP_499964.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPL15B¹	Rpl15bp	60.92(n) 71.92(a)		855150 NP_013840.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G16720⁶ AT4G17390⁶	60S ribosomal protein L15-2	70(a) 69(a)	many → 1 many → 1	4(9399960-9401382) 4(9714092-9715612)
rice (Oryza sativa)	Liliopsida	CA754173.1²	--	76.25(n)		CA754173.1

ENSEMBL Gene Tree for RPL15 (if available)
TreeFam Gene Tree for RPL15 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RPL15 gene

1 SIMAP similar gene for RPL15 using alignment to 5 protein entries: RL15_HUMAN (see all proteins):

LOC136321

RPL15 for paralogs About GeneDecksing

5/31 Pseudogenes.org Pseudogenes for RPL15 (see all 31)
PGOHUM00000251261 PGOHUM00000238834 PGOHUM00000238929 PGOHUM00000250391 PGOHUM00000242795

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111935409^1,2	C,	--	23956434(+)	`CACCTT/CTGAAA`	4	--	us2k¹ int¹		2		CSA WA	120
rs190185349^1,2		--	23956474(+)	`TCATCA/GCTACT`	4	--	int¹ us2k¹		0	--	--	--	--
rs35693812^1,2	C,	--	23956488(-)	`ACCCAG/AACCAC`	4	--	us2k¹ int¹		2		NS	86
rs143864188^1,2		--	23956532(+)	`GATATC/TGTAAT`	4	--	us2k¹ int¹		0	--	--	--	--
rs147251919^1,2		--	23956551(+)	`CCTGTA/GAATAT`	4	--	int¹ us2k¹		0	--	--	--	--
rs4858556^1,2	C,F,A,	--	23956575(+)	`actcaT/Aacaag`	4	--	us2k¹ int¹		11		NA NS WA CSA	464
rs4241514^1,2	C,F,A,	--	23956617(-)	`TCTTCA/GTATGG`	4	--	us2k¹ int¹		15		NS NA WA CSA EA	582
rs139001046^1,2		--	23956623(+)	`GAAGAC/TATTAT`	5	--	us2k¹ int¹		0	--	--	--	--
rs181217750^1,2		--	23956654(+)	`CCAGTA/GTAATC`	6	--	us2k¹ int¹		0	--	--	--	--
rs13100706^1,2	C,F,	--	23956704(+)	`GGACAG/CAAGGT`	6	--	us2k¹ int¹		11		NS NA WA EA	590

HapMap Linkage Disequilibrium report for RPL15 (23958036 - 23965183 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RPL15: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RPL15 for disorders           About GeneDecksing

OMIM gene information: 604174    OMIM disorders: --

14 diseases for RPL15:    About MalaCards

diamond-blackfan anemia esophagitis treacher collins syndrome actinic keratosis

papillary thyroid carcinoma keratosis folliculitis thyroid carcinoma

anemia thyroiditis esophageal cancer gastric cancer

carcinoma malaria

Human Genome Epidemiology (HuGE) Navigator: RPL15 (1 document)

Export disorders for RPL15 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RPL15 gene, integrated from 9 sources (see all 49):
(articles sorted by number of sources associating them with RPL15)

Utopia: connect your pdf to the dynamic
world of online information

A novel interaction between interferon-inducible prot ein p56 and ribosomal protein L15 in gastric cancer cells. (PubMed id 21612406)^{1, 2} Hsu Y.A....Chen B.H. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A map of 75 human ribosomal protein genes. (PubMed id 9582194)^{1, 3} Kenmochi N.... Page D.C. (1998)
Cloning and characterization of full-length human ribosomal protein L15 cDNA which was overexpressed in esophageal cancer. (PubMed id 11223259)^{1, 9} Wang Q....Liu Z. (2001)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
A yeast two-hybrid screen reveals that osteopontin ass ociates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)¹ Long P....Rose S. (2012)
Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)¹ Tsai Y.C....Cristea I.M. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6138	HGNC: 10306	AceView: RPL15	Ensembl:ENSG00000174748	euGenes: HUgn6138
ECgene: RPL15	Kegg: 6138	H-InvDB: RPL15

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RPL15	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RPL15	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RPL15 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RPL15 gene:
Search GeneIP for patents involving RPL15

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ribosomal protein L15

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RPL15 Gene

ribosomal protein L15

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