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Aliases for RPL15 Gene

Aliases for RPL15 Gene

  • Ribosomal Protein L15 2 3 5
  • EC45 3 4
  • RPLY10 3
  • RPYL10 3
  • DBA12 3
  • RPL10 3
  • L15 3

External Ids for RPL15 Gene

Previous GeneCards Identifiers for RPL15 Gene

  • GC03M023392
  • GC03P023641
  • GC03P023807
  • GC03P023933

Summaries for RPL15 Gene

Entrez Gene Summary for RPL15 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15E family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Although this gene has been referred to as RPL10, its official symbol is RPL15. This gene has been shown to be overexpressed in some esophageal tumors compared to normal matched tissues. Alternate splicing results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Nov 2011]

GeneCards Summary for RPL15 Gene

RPL15 (Ribosomal Protein L15) is a Protein Coding gene. Diseases associated with RPL15 include diamond-blackfan anemia 12 and diamond-blackfan anemia. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL15 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL15 Gene

Genomics for RPL15 Gene

Regulatory Elements for RPL15 Gene

Promoters for RPL15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL15 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL15 Gene

Chromosome:
3
Start:
23,916,545 bp from pter
End:
23,923,696 bp from pter
Size:
7,152 bases
Orientation:
Plus strand

Genomic View for RPL15 Gene

Genes around RPL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL15 Gene

Proteins for RPL15 Gene

  • Protein details for RPL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61313-RL15_HUMAN
    Recommended name:
    60S ribosomal protein L15
    Protein Accession:
    P61313
    Secondary Accessions:
    • P39030
    • P41051
    • Q5U0C0
    • Q642I1
    • Q6IPX6
    • Q8WYP2
    • Q96C44
    • Q9H2E5

    Protein attributes for RPL15 Gene

    Size:
    204 amino acids
    Molecular mass:
    24146 Da
    Quaternary structure:
    • Interacts with IFIT1 (via TPR repeats 1-4).
    SequenceCaution:
    • Sequence=AAA36583.1; Type=Frameshift; Positions=199; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL15 Gene

    Alternative splice isoforms for RPL15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPL15 Gene

Proteomics data for RPL15 Gene at MOPED

Post-translational modifications for RPL15 Gene

  • Ubiquitination at Lys 5, Lys 56, Lys 83, Lys 93, Lys 140, Lys 153, Lys 157, and Lys 179
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RPL15 Gene

Domains & Families for RPL15 Gene

Gene Families for RPL15 Gene

Protein Domains for RPL15 Gene

Graphical View of Domain Structure for InterPro Entry

P61313

UniProtKB/Swiss-Prot:

RL15_HUMAN :
  • Belongs to the ribosomal protein L15e family.
Family:
  • Belongs to the ribosomal protein L15e family.
genes like me logo Genes that share domains with RPL15: view

Function for RPL15 Gene

Molecular function for RPL15 Gene

GENATLAS Biochemistry:
60S ribosomal protein L15

Gene Ontology (GO) - Molecular Function for RPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21612406
genes like me logo Genes that share ontologies with RPL15: view
genes like me logo Genes that share phenotypes with RPL15: view

Human Phenotype Ontology for RPL15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL15 Gene

Localization for RPL15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL15 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL15 Gene COMPARTMENTS Subcellular localization image for RPL15 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RPL15: view

Pathways & Interactions for RPL15 Gene

genes like me logo Genes that share pathways with RPL15: view

Pathways by source for RPL15 Gene

2 BioSystems pathways for RPL15 Gene
1 KEGG pathway for RPL15 Gene
1 GeneGo (Thomson Reuters) pathway for RPL15 Gene
1 R&D Systems pathway for RPL15 Gene
1 Qiagen pathway for RPL15 Gene

Gene Ontology (GO) - Biological Process for RPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL15: view

No data available for SIGNOR curated interactions for RPL15 Gene

Drugs & Compounds for RPL15 Gene

(3) Drugs for RPL15 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
anisomycin Experimental Pharma Target JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL15: view

Transcripts for RPL15 Gene

Unigene Clusters for RPL15 Gene

Ribosomal protein L15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL15 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for RPL15 Gene

GeneLoc Exon Structure for
RPL15
ECgene alternative splicing isoforms for
RPL15

Expression for RPL15 Gene

mRNA expression in normal human tissues for RPL15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL15 Gene

This gene is overexpressed in Ovary (6.5) and Saliva (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL15 Gene



SOURCE GeneReport for Unigene cluster for RPL15 Gene Hs.381219

genes like me logo Genes that share expression patterns with RPL15: view

Protein tissue co-expression partners for RPL15 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL15 Gene

Orthologs for RPL15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPL15 35
  • 89.54 (n)
  • 100 (a)
RPL15 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL15 35
  • 93.14 (n)
  • 100 (a)
RPL15 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl15 35
  • 93.14 (n)
  • 100 (a)
Rpl15 16
Rpl15 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPL15 35
  • 99.67 (n)
  • 100 (a)
RPL15 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl15 35
  • 91.67 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RPL15 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL15 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL15 35
  • 83.17 (n)
  • 99.51 (a)
RPL15 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL15 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl15 35
  • 81.86 (n)
  • 93.63 (a)
Str.6192 35
African clawed frog
(Xenopus laevis)
Amphibia rpl15-prov 35
zebrafish
(Danio rerio)
Actinopterygii rpl15 35
  • 79.08 (n)
  • 95.59 (a)
rpl15 36
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RpL15 37
  • 74 (a)
RpL15 35
  • 64.71 (n)
  • 74.02 (a)
RpL15 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta RL15_ANOGA 35
  • 66.5 (n)
  • 74.02 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-15 37
  • 76 (a)
rpl-15 36
  • 76 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR214C 35
  • 62.56 (n)
  • 70.44 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17633g 35
  • 61.74 (n)
  • 71.92 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL15B 35
  • 60.92 (n)
  • 71.92 (a)
RPL15A 36
  • 71 (a)
OneToMany
RPL15B 36
  • 71 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16720 35
  • 65.35 (n)
  • 70.44 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10328 35
rice
(Oryza sativa)
Liliopsida Os05g0274700 35
  • 67 (n)
  • 72.41 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.26531 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10603 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01776 35
  • 64.53 (n)
  • 72.91 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl15 35
  • 65.67 (n)
  • 72.64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7913 36
  • 83 (a)
OneToOne
Species with no ortholog for RPL15:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL15 Gene

ENSEMBL:
Gene Tree for RPL15 (if available)
TreeFam:
Gene Tree for RPL15 (if available)

Paralogs for RPL15 Gene

(1) SIMAP similar genes for RPL15 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RPL15: view

No data available for Paralogs for RPL15 Gene

Variants for RPL15 Gene

Sequence variations from dbSNP and Humsavar for RPL15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1133926 -- 23,920,271(+) GGGGG(A/G)AAGTA intron-variant, utr-variant-3-prime
rs1134960 -- 23,920,745(+) TTGAG(A/C)CCTAA intron-variant, utr-variant-3-prime
rs1135002 -- 23,920,759(+) TCTTC(A/C)CAAAA intron-variant, utr-variant-3-prime
rs1141621 -- 23,920,367(+) AAAAA(A/G)TCACA intron-variant, utr-variant-3-prime
rs1141622 -- 23,920,369(+) AAAGT(A/C)ACAAG intron-variant, utr-variant-3-prime

Variation tolerance for RPL15 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL15 Gene

HapMap Linkage Disequilibrium report
RPL15
Human Gene Mutation Database (HGMD)
RPL15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPL15 Gene

Disorders for RPL15 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RPL15 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 12
  • dba12
diamond-blackfan anemia
  • blackfan - diamond syndrome
rpl15-related diamond-blackfan anemia
  • diamond-blackfan anemia 12
macrocytic anemia
  • anemia macrocytic
pierre robin syndrome
  • pierre robin sequence
- elite association - COSMIC cancer census association via MalaCards
Search RPL15 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RL15_HUMAN
  • Diamond-Blackfan anemia 12 (DBA12) [MIM:615550]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:23812780}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPL15

Genetic Association Database (GAD)
RPL15
Human Genome Epidemiology (HuGE) Navigator
RPL15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL15
genes like me logo Genes that share disorders with RPL15: view

No data available for Genatlas for RPL15 Gene

Publications for RPL15 Gene

  1. Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia. (PMID: 23812780) Landowski M. … Gazda H.T. (Hum. Genet. 2013) 3 4 67
  2. Cloning and characterization of full-length human ribosomal protein L15 cDNA which was overexpressed in esophageal cancer. (PMID: 11223259) Wang Q. … Liu Z. (Gene 2001) 3 23
  3. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for RPL15 Gene

Sources for RPL15 Gene

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