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Aliases for RPL15 Gene

Aliases for RPL15 Gene

  • Ribosomal Protein L15 2 3
  • EC45 3 4
  • RPLY10 3
  • RPYL10 3
  • DBA12 3
  • RPL10 3
  • L15 3

External Ids for RPL15 Gene

Previous GeneCards Identifiers for RPL15 Gene

  • GC03M023392
  • GC03P023641
  • GC03P023807
  • GC03P023933

Summaries for RPL15 Gene

Entrez Gene Summary for RPL15 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15E family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Although this gene has been referred to as RPL10, its official symbol is RPL15. This gene has been shown to be overexpressed in some esophageal tumors compared to normal matched tissues. Alternate splicing results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Nov 2011]

GeneCards Summary for RPL15 Gene

RPL15 (Ribosomal Protein L15) is a Protein Coding gene. Diseases associated with RPL15 include rpl15-related diamond-blackfan anemia and diamond-blackfan anemia 12. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL15 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL15 Gene

Genomics for RPL15 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPL15 Gene

23,916,545 bp from pter
23,923,696 bp from pter
7,152 bases
Plus strand

Genomic View for RPL15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL15 Gene

Proteins for RPL15 Gene

  • Protein details for RPL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L15
    Protein Accession:
    Secondary Accessions:
    • P39030
    • P41051
    • Q5U0C0
    • Q642I1
    • Q6IPX6
    • Q8WYP2
    • Q96C44
    • Q9H2E5

    Protein attributes for RPL15 Gene

    204 amino acids
    Molecular mass:
    24146 Da
    Quaternary structure:
    • Interacts with IFIT1 (via TPR repeats 1-4).
    • Sequence=AAA36583.1; Type=Frameshift; Positions=199; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL15 Gene

    Alternative splice isoforms for RPL15 Gene


neXtProt entry for RPL15 Gene

Proteomics data for RPL15 Gene at MOPED

Post-translational modifications for RPL15 Gene

  • Ubiquitination at Lys 5, Lys 56, Lys 83, Lys 93, Lys 140, Lys 153, Lys 157, and Lys 179
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RPL15 Gene

Domains & Families for RPL15 Gene

Gene Families for RPL15 Gene

Protein Domains for RPL15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L15e family.
  • Belongs to the ribosomal protein L15e family.
genes like me logo Genes that share domains with RPL15: view

Function for RPL15 Gene

Molecular function for RPL15 Gene

GENATLAS Biochemistry:
60S ribosomal protein L15

Gene Ontology (GO) - Molecular Function for RPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9582194
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 21612406
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL15: view
genes like me logo Genes that share phenotypes with RPL15: view

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL15

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL15 Gene

Localization for RPL15 Gene

Subcellular locations from

Jensen Localization Image for RPL15 Gene COMPARTMENTS Subcellular localization image for RPL15 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for RPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0005840 ribosome TAS 9582194
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
genes like me logo Genes that share ontologies with RPL15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL15 Gene

Pathways & Interactions for RPL15 Gene

genes like me logo Genes that share pathways with RPL15: view

Pathways by source for RPL15 Gene

1 Qiagen pathway for RPL15 Gene
1 Cell Signaling Technology pathway for RPL15 Gene
2 BioSystems pathways for RPL15 Gene
1 KEGG pathway for RPL15 Gene
1 GeneGo (Thomson Reuters) pathway for RPL15 Gene
1 R&D Systems pathway for RPL15 Gene

Gene Ontology (GO) - Biological Process for RPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPL15: view

No data available for SIGNOR curated interactions for RPL15 Gene

Drugs & Compounds for RPL15 Gene

(3) Drugs for RPL15 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
anisomycin Experimental Pharma Target JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL15: view

Transcripts for RPL15 Gene

Unigene Clusters for RPL15 Gene

Ribosomal protein L15:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL15 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for RPL15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL15 Gene

mRNA expression in normal human tissues for RPL15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL15 Gene

This gene is overexpressed in Ovary (6.5) and Saliva (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL15 Gene

SOURCE GeneReport for Unigene cluster for RPL15 Gene Hs.381219

genes like me logo Genes that share expression patterns with RPL15: view

Protein tissue co-expression partners for RPL15 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL15 Gene

Orthologs for RPL15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL15 35
  • 89.54 (n)
  • 100 (a)
RPL15 36
  • 100 (a)
(Canis familiaris)
Mammalia RPL15 35
  • 93.14 (n)
  • 100 (a)
RPL15 36
  • 100 (a)
(Mus musculus)
Mammalia Rpl15 35
  • 93.14 (n)
  • 100 (a)
Rpl15 16
Rpl15 36
  • 100 (a)
(Pan troglodytes)
Mammalia RPL15 35
  • 99.67 (n)
  • 100 (a)
RPL15 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rpl15 35
  • 91.67 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RPL15 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia RPL15 36
  • 100 (a)
(Gallus gallus)
Aves RPL15 35
  • 83.17 (n)
  • 99.51 (a)
RPL15 36
  • 100 (a)
(Anolis carolinensis)
Reptilia RPL15 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl15 35
  • 81.86 (n)
  • 93.63 (a)
Str.6192 35
African clawed frog
(Xenopus laevis)
Amphibia rpl15-prov 35
(Danio rerio)
Actinopterygii rpl15 35
  • 79.08 (n)
  • 95.59 (a)
rpl15 36
  • 96 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL15 37
  • 74 (a)
RpL15 35
  • 64.71 (n)
  • 74.02 (a)
RpL15 36
  • 74 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta RL15_ANOGA 35
  • 66.5 (n)
  • 74.02 (a)
(Caenorhabditis elegans)
Secernentea rpl-15 37
  • 76 (a)
rpl-15 36
  • 76 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR214C 35
  • 62.56 (n)
  • 70.44 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17633g 35
  • 61.74 (n)
  • 71.92 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL15B 35
  • 60.92 (n)
  • 71.92 (a)
RPL15A 36
  • 71 (a)
RPL15B 36
  • 71 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16720 35
  • 65.35 (n)
  • 70.44 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10328 35
(Oryza sativa)
Liliopsida Os05g0274700 35
  • 67 (n)
  • 72.41 (a)
(Triticum aestivum)
Liliopsida Ta.26531 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10603 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01776 35
  • 64.53 (n)
  • 72.91 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl15 35
  • 65.67 (n)
  • 72.64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7913 36
  • 83 (a)
Species with no ortholog for RPL15:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL15 Gene

Gene Tree for RPL15 (if available)
Gene Tree for RPL15 (if available)

Paralogs for RPL15 Gene

(1) SIMAP similar genes for RPL15 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RPL15: view

No data available for Paralogs for RPL15 Gene

Variants for RPL15 Gene

Sequence variations from dbSNP and Humsavar for RPL15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1057036 -- 23,919,488(+) GCTCC(A/C)CCGTT reference, missense, intron-variant
rs1064252 -- 23,919,428(+) GTTCC(A/C)CCACA reference, missense, intron-variant
rs1133926 -- 23,920,271(+) GGGGG(A/G)AAGTA utr-variant-3-prime, intron-variant
rs1134960 -- 23,920,745(+) TTGAG(A/C)CCTAA utr-variant-3-prime, intron-variant
rs1135002 -- 23,920,759(+) TCTTC(A/C)CAAAA utr-variant-3-prime, intron-variant

Variation tolerance for RPL15 Gene

Residual Variation Intolerance Score: 61.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL15 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPL15 Gene

Disorders for RPL15 Gene

MalaCards: The human disease database

(6) MalaCards diseases for RPL15 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
rpl15-related diamond-blackfan anemia
  • diamond-blackfan anemia 12
diamond-blackfan anemia 12
  • dba12
diamond-blackfan anemia
  • chronic constitutional pure red cell anaemia
pierre robin syndrome
  • pierre robin sequence
macrocytic anemia
  • macrocytic anemia of unspecified cause
- elite association
Search RPL15 in MalaCards View complete list of genes associated with diseases


  • Diamond-Blackfan anemia 12 (DBA12) [MIM:615550]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:23812780}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPL15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL15: view

No data available for Genatlas for RPL15 Gene

Publications for RPL15 Gene

  1. Cloning and characterization of full-length human ribosomal protein L15 cDNA which was overexpressed in esophageal cancer. (PMID: 11223259) Wang Q. … Liu Z. (Gene 2001) 23 67
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for RPL15 Gene

Sources for RPL15 Gene

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