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RPL14 Gene

protein-coding   GIFtS: 60
GCID: GC03P040501

Ribosomal Protein L14

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein L141 2     L142
CAG-ISL 71 3     RL142
60S Ribosomal Protein L141 2     hRL142
CAG-ISL-72     MMRPL325
CTG-B332     

External Ids:    HGNC: 103051   Entrez Gene: 90452   Ensembl: ENSG000001888467   OMIM: 6118275   UniProtKB: P509143   

Export aliases for RPL14 gene to outside databases

Previous GC identifers: GC03P039807 GC03P039727 GC03P040312 GC03P040459 GC03P040473


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL14 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family
of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in
the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these
triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing
alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical
for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through
the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPL14 Gene:
RPL14 (ribosomal protein L14) is a protein-coding gene. Diseases associated with RPL14 include mucocutaneous leishmaniasis, and congenital myasthenic syndrome. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

Gene Wiki entry for RPL14 (60S ribosomal protein L14) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL14 gene promoter:
         HEN1   E2F-1   E2F   Pax-4a   Nkx5-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL14 promoter sequence
   Search Chromatin IP Primers for RPL14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22-p21.2   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p22-p21.2

RPL14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL14 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P040501:  view genomic region     (about GC identifiers)

Start:
40,498,783 bp from pter      End:
40,503,861 bp from pter
Size:
5,079 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RL14_HUMAN, P50914 (See protein sequence)
Recommended Name: 60S ribosomal protein L14  
Size: 215 amino acids; 23432 Da
1 PDB 3D structure from and Proteopedia for RPL14:
3J3B (3D)    
Secondary accessions: Q45RF0 Q53G20 Q8TBD5 Q8WUT0 Q92579 Q96GR0 Q9BSB8 Q9BW65 Q9BYF6

Explore the universe of human proteins at neXtProt for RPL14: NX_P50914

Explore proteomics data for RPL14 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys53, Lys71, Lys85
  • Modification sites at PhosphoSitePlus

  • See RPL14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001030168.1  NP_003964.3  

    ENSEMBL proteins: 
     ENSP00000345156   ENSP00000379506   ENSP00000391446   ENSP00000402476  
    Reactome Protein details: P50914

    RPL14 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for RPL14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    3 InterPro protein domains:
     IPR002784 Ribosomal_L14
     IPR014722 Rib_L2_dom2
     IPR008991 Translation_prot_SH3-like

    Graphical View of Domain Structure for InterPro Entry P50914

    ProtoNet protein and cluster: P50914

    1 Blocks protein domain: IPB002784 Ribosomal protein L14

    UniProtKB/Swiss-Prot: RL14_HUMAN, P50914
    Similarity: Belongs to the ribosomal protein L14e family


    RPL14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS9480843
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0005515protein binding IPI11369516
    GO:0044822poly(A) RNA binding IDA--
         
    RPL14 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RPL14:
     Elongated cells  Increased gamma-H2AX phosphory  Nuclear 60S biogenesis defects  Nuclear pre-40S maturation def 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL14
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPL14

    miRNA
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    miRTarBase miRNAs that target RPL14:
    hsa-mir-181a-5p (MIRT047311), hsa-mir-16-5p (MIRT031990), hsa-mir-100-5p (MIRT048582), hsa-mir-186-5p (MIRT045056), hsa-mir-769-5p (MIRT039154)

    Block miRNA regulation of human, mouse, rat RPL14 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate RPL14:
    hsa-miR-3613-3p hsa-miR-548b-3p hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidRPL14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RPL14
    Predesigned siRNA for gene silencing in human, mouse, rat RPL14

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    GenScript: all cDNA clones in your preferred vector (see all 2): RPL14 (NM_003973)
    Sino Biological Human cDNA Clone for RPL14
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL14

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    chloroplast2
    mitochondrion2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325

    RPL14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPL14 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL14
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL14
        Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPL14 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL14):
        Ribosome


    RPL14 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL14
    Interactions:

        Search GeneGlobe Interaction Network for RPL14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL14 (P509141, 2, 3 ENSP000003451564) via UniProtKB, MINT, STRING, and/or I2D (see all 404)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS6P627532, 3, ENSP000003697574MINT-6488590 MINT-6488791 I2D: score=2 STRING: ENSP00000369757
    RPL11P629132, 3, ENSP000003636764MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000363676
    RPL13P263732, 3, ENSP000003078894MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000307889
    RPL19P840982, 3, ENSP000002254304MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000225430
    RPL21P467782, 3, ENSP000003460274MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000346027
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006364rRNA processing IMP18697920
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--

    RPL14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL14 (RL14)

    1 Novoseek inferred chemical compound relationship for RPL14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alanine 26.4 1 9920051 (1)



    RPL14 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPL14 gene (2 alternative transcripts): 
    NM_001034996.2  NM_003973.4  

    Unigene Cluster for RPL14:

    Ribosomal protein L14
    Hs.446522  [show with all ESTs]
    Unigene Representative Sequence: BF572302
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338970(uc003ckg.3) ENST00000465325 ENST00000396203(uc003ckh.3)
    ENST00000416518 ENST00000435633 ENST00000479563 ENST00000465280 ENST00000481798
    ENST00000461368
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate RPL14:
    hsa-miR-3613-3p hsa-miR-548b-3p hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidRPL14 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): RPL14 (NM_003973)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPL14
      QuantiTect SYBR Green Assays in human, mouse, rat RPL14
      QuantiFast Probe-based Assays in human, mouse, rat RPL14

    Additional mRNA sequence: 

    AK126111.1 AK222750.1 AK223111.1 AK290674.1 AK292045.1 AK300873.1 BC000606.2 BC005134.2 
    BC009294.2 BC016379.1 BC019651.1 BC022805.1 BC029036.1 BC071913.1 D87735.1 DQ118667.1 
    L10376.1 U16738.1 U92982.1 

    Selected DOTS entries (see all 116):

    DT.91782889  DT.87011905  DT.100727687  DT.95212329  DT.95328639  DT.95370573  DT.120902869  DT.91931268 
    DT.100838985  DT.100838988  DT.91782989  DT.95370581  DT.91782830  DT.95370800  DT.100891055  DT.95221748 
    DT.97847984  DT.95224725  DT.95127987  DT.95365418  DT.92340075  DT.100838987  DT.100891027  DT.91782832 

    Selected AceView cDNA sequences (see all 1840):

    BE928680 BM550430 AW605744 AW937222 BE167089 AA605170 BG985952 AA314365 
    CR618270 BE042117 BU154089 AI888325 AA356719 BE280528 BM311048 BU167421 
    BF718764 AW877741 BQ012486 BE167111 AA312529 BE070682 F30402 BU156058 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPL14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCTCACTG
    RPL14 Expression
    About this image


    RPL14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
             Nucleus Pulposus
     
     Primitive Streak (Early Embryonic Tissues)
             Notochord
     
     Smooth Muscle (Muscoskeletal System)
     
     Ovary (Reproductive System)
    RPL14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446522
        Custom PCR Arrays for RPL14
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL14 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl141 , 5 ribosomal protein L141, 5 85.58(n)1
    86.51(a)1
      9 (71.74 cM)5
    671151  NM_025974.21  NP_080250.11 
     1205715175 
    chicken
    (Gallus gallus)
    Aves RPL141 ribosomal protein L14 79.04(n)
    85.61(a)
      374134  XM_418775.4  XP_418775.3 
    lizard
    (Anolis carolinensis)
    Reptilia RPL146
    ribosomal protein L14
    83(a)
    1 ↔ 1
    6(36030303-36037094)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB592084.12   -- 78.82(n)    CB592084.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rpl141 ribosomal protein L14 72.39(n)
    72.39(a)
      323365  NM_001002866.1  NP_001002866.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL141 Ribosomal protein L14 51.3(n)
    42.55(a)
      38983  NM_079251.4  NP_523975.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-141 rpl-14 54.89(n)
    48.12(a)
      172818  NM_060175.6  NP_492576.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL14A6
    RPL14B6
    N-terminally acetylated protein component of the l...
    Protein component of the large (60S) ribosomal sub...
    40(a)
    40(a)
    many → 1
    many → 1
    XI(431906-432720) YKL006W
    VIII(104277-105091) YHL001W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G204501 AT2G20450 54.62(n)
    46.15(a)
      816564  NM_127604.3  NP_179635.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g05153001 Os04g0515300 54.8(n)
    47.73(a)
      4336397  NM_001059845.1  NP_001053310.1 


    ENSEMBL Gene Tree for RPL14 (if available)
    TreeFam Gene Tree for RPL14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPL14 gene

    RPL14 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPL14 (see all 7)
    PGOHUM00000251027 PGOHUM00000240059 PGOHUM00000240902 PGOHUM00000250242 PGOHUM00000245711


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    RL14_HUMAN, P50914: The poly-Ala stretch is highly polymorphic


    Selected SNPs for RPL14 (see all 246)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs98588791,2
    C,H--40496944(+) gctgaG/Agcaga 2 -- us2k113Minor allele frequency- A:0.06NA WA CSA EA NS 523
    rs98590501,2
    C,H--40497076(+) TGGCCG/AAGCAC 2 -- us2k115Minor allele frequency- A:0.07NA WA CSA EA NS 507
    rs98590571,2
    C,H--40497082(+) AGCACG/AGTGGC 2 -- us2k111Minor allele frequency- A:0.05NA WA CSA EA 371
    rs98591851,2
    C,H--40497127(+) AGGCAG/AGTGAA 2 -- us2k113Minor allele frequency- A:0.04NA WA CSA EA NS 213
    rs1846735011,2
    --40497214(+) CGGGCA/GTGGTG 2 -- us2k10--------
    rs1464229651,2
    --40497244(+) GGTACG/TTGGGA 2 -- us2k10--------
    rs775887431,2
    C--40497275(+) TGAACC/TCGGGA 2 -- us2k10--------
    rs749979481,2
    C--40497276(+) GAACCA/CGGGAG 2 -- us2k10--------
    rs1120825021,2
    F--40497281(+) CGGGAG/AGCAGA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1480605131,2
    C--40497325(+) TGAGCC/TGAGAT 2 -- us2k11Minor allele frequency- T:0.01NS 134

    HapMap Linkage Disequilibrium report for RPL14 (40498783 - 40503861 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RPL14:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv818137CNV Loss17921354
    nsv876716CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL14
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 611827    OMIM disorders: --

    12 diseases for RPL14:    
    About MalaCards
    mucocutaneous leishmaniasis    congenital myasthenic syndrome    treacher collins syndrome    diamond-blackfan anemia
    leishmaniasis    oral cancer    influenza    squamous cell carcinoma
    pancreatitis    endotheliitis    breast cancer    malaria

    1 disease from the University of Copenhagen DISEASES database for RPL14:
    Diamond-Blackfan anemia

    RPL14 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RPL14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 23.2 3 16316724 (2), 9920051 (1)
    tumors 0 5 16316724 (4)


    Export disorders for RPL14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for RPL14 gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with RPL14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Triplet repeat-containing ribosomal protein L14 gene in immortalized human endothelial cell line (t-HUE4). (PubMed id 9480843)1, 2, 3, 9 Tanaka M.... Mitsui Y. (Biochem. Biophys. Res. Commun. 1998)
    2. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2, 9 Odintsova T.I....Karpova G.G. (J. Protein Chem. 2003)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    6. A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. (PubMed id 11401437)1, 2 Uechi T.... Kenmochi N. (Genomics 2001)
    7. Identification of trinucleotide repeat-containing genes in human pancreatic islets. (PubMed id 8549859)1, 2 Aoki M.... Permutt M.A. (Diabetes 1996)
    8. Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription. (PubMed id 24140708)1 Wu T....Zhang D.D. (amp 2014)
    9. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9045 HGNC: 10305 AceView: RPL14 Ensembl:ENSG00000188846 euGenes: HUgn9045
    ECgene: RPL14 Kegg: 9045 H-InvDB: RPL14

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RPL14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RPL14 gene:
    Search GeneIP for patents involving RPL14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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