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Aliases for RPL14 Gene

Aliases for RPL14 Gene

  • Ribosomal Protein L14 2 3 5
  • Large Ribosomal Subunit Protein EL14 3 4
  • 60S Ribosomal Protein L14 2 3
  • CAG-ISL 7 2 4
  • CAG-ISL-7 3
  • CTG-B33 3
  • HRL14 3
  • RL14 3
  • L14 3

External Ids for RPL14 Gene

Previous GeneCards Identifiers for RPL14 Gene

  • GC03P039807
  • GC03P039727
  • GC03P040312
  • GC03P040459
  • GC03P040473

Summaries for RPL14 Gene

Entrez Gene Summary for RPL14 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL14 Gene

RPL14 (Ribosomal Protein L14) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL14 Gene

  • Component of the large ribosomal subunit.

Gene Wiki entry for RPL14 Gene

Additional gene information for RPL14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL14 Gene

Genomics for RPL14 Gene

Regulatory Elements for RPL14 Gene

Enhancers for RPL14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H039638 1.5 FANTOM5 Ensembl ENCODE 10.4 -817.8 -817752 2 HNRNPUL1 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 FOS ZNF619 RPL14 CSRNP1 NFU1P1 MOBP
GH03H040313 1.1 FANTOM5 ENCODE 13.4 -143.0 -143006 1 HNRNPUL1 TBL1XR1 TAL1 TCF12 GATA2 NCOR1 POLR2A HNF4G TRIM24 PAF1 ENTPD3-AS1 RPL14 ZNF619 ENSG00000234287 EIF1B-AS1 PGAM1P3
GH03H040503 1.1 ENCODE 10.6 +48.1 48138 2 PKNOX1 FOXA2 ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF143 FOS ZHX2 ZNF619 RPL14 ENTPD3-AS1 ZNF620 ZNF621
GH03H040464 0.7 ENCODE 13.3 +7.5 7455 0 HNRNPUL1 HDGF ELF4 NFXL1 ZEB2 ZNF592 NFIC POLR2A EGR1 IKZF1 ENTPD3-AS1 RPL14 ZNF619 RNU5B-2P ZNF620 ENSG00000234287 PIR56082
GH03H040417 0.8 ENCODE 10.8 -39.2 -39234 0 HDAC1 PKNOX1 ATF1 NFXL1 CHAMP1 TCF12 ZNF766 GATA2 FOS RCOR1 ENTPD3-AS1 RPL14 GC03P040390
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL14 on UCSC Golden Path with GeneCards custom track

Promoters for RPL14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151173 208 1801 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS

Genomic Location for RPL14 Gene

Chromosome:
3
Start:
40,457,292 bp from pter
End:
40,468,587 bp from pter
Size:
11,296 bases
Orientation:
Plus strand

Genomic View for RPL14 Gene

Genes around RPL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL14 Gene

Proteins for RPL14 Gene

  • Protein details for RPL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50914-RL14_HUMAN
    Recommended name:
    60S ribosomal protein L14
    Protein Accession:
    P50914
    Secondary Accessions:
    • Q45RF0
    • Q53G20
    • Q8TBD5
    • Q8WUT0
    • Q92579
    • Q96GR0
    • Q9BSB8
    • Q9BW65
    • Q9BYF6

    Protein attributes for RPL14 Gene

    Size:
    215 amino acids
    Molecular mass:
    23432 Da
    Quaternary structure:
    • Component of the large ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPL14 Gene

neXtProt entry for RPL14 Gene

Post-translational modifications for RPL14 Gene

  • Ubiquitination at Lys53 and Lys71
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL14 Gene

No data available for DME Specific Peptides for RPL14 Gene

Domains & Families for RPL14 Gene

Gene Families for RPL14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL14 Gene

Graphical View of Domain Structure for InterPro Entry

P50914

UniProtKB/Swiss-Prot:

RL14_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL14 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL14 family.
genes like me logo Genes that share domains with RPL14: view

Function for RPL14 Gene

Molecular function for RPL14 Gene

UniProtKB/Swiss-Prot Function:
Component of the large ribosomal subunit.

Gene Ontology (GO) - Molecular Function for RPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,TAS 22658674
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 11369516
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with RPL14: view
genes like me logo Genes that share phenotypes with RPL14: view

Animal Model Products

CRISPR Products

miRNA for RPL14 Gene

miRTarBase miRNAs that target RPL14

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPL14
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL14 Gene

Localization for RPL14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL14 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA,TAS 12962325
genes like me logo Genes that share ontologies with RPL14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL14 Gene

Pathways & Interactions for RPL14 Gene

genes like me logo Genes that share pathways with RPL14: view

Pathways by source for RPL14 Gene

1 KEGG pathway for RPL14 Gene
1 GeneGo (Thomson Reuters) pathway for RPL14 Gene

Gene Ontology (GO) - Biological Process for RPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,IEA 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL14: view

No data available for SIGNOR curated interactions for RPL14 Gene

Drugs & Compounds for RPL14 Gene

(1) Drugs for RPL14 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RPL14: view

Transcripts for RPL14 Gene

Unigene Clusters for RPL14 Gene

Ribosomal protein L14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPL14
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RPL14 Gene

No ASD Table

Relevant External Links for RPL14 Gene

GeneLoc Exon Structure for
RPL14
ECgene alternative splicing isoforms for
RPL14

Expression for RPL14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL14 Gene

This gene is overexpressed in Tlymphocyte (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL14 Gene



Protein tissue co-expression partners for RPL14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL14 Gene:

RPL14

SOURCE GeneReport for Unigene cluster for RPL14 Gene:

Hs.446522

Evidence on tissue expression from TISSUES for RPL14 Gene

  • Kidney(4.9)
  • Skin(4.9)
  • Nervous system(4.9)
  • Lung(4.7)
  • Pancreas(4.7)
  • Muscle(4.6)
  • Intestine(4.3)
  • Thyroid gland(4.1)
  • Eye(3.6)
  • Liver(3.4)
  • Blood(3.3)
  • Heart(3)
  • Spleen(2.7)
  • Bone(2.4)
  • Stomach(2.2)
  • Lymph node(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with RPL14: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL14 Gene

Orthologs for RPL14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL14 33 34
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia RPL14 33 34 34
  • 89.52 (n)
cow
(Bos Taurus)
Mammalia RPL14 33 34
  • 88.47 (n)
mouse
(Mus musculus)
Mammalia Rpl14 16 34 33
  • 85.58 (n)
rat
(Rattus norvegicus)
Mammalia Rpl14 33
  • 84.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPL14 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPL14 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL14 33 34
  • 79.04 (n)
lizard
(Anolis carolinensis)
Reptilia RPL14 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl14 33
  • 76.09 (n)
zebrafish
(Danio rerio)
Actinopterygii rpl14 33 34
  • 72.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005991 33
  • 51.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL14 33 34
  • 51.3 (n)
worm
(Caenorhabditis elegans)
Secernentea rpl-14 33 34
  • 54.89 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13409g 33
  • 52 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR005C 33
  • 49.23 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL14A 34
  • 40 (a)
OneToMany
RPL14B 34
  • 40 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20450 33
  • 54.62 (n)
rice
(Oryza sativa)
Liliopsida Os04g0515300 33
  • 54.8 (n)
Species where no ortholog for RPL14 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL14 Gene

ENSEMBL:
Gene Tree for RPL14 (if available)
TreeFam:
Gene Tree for RPL14 (if available)

Paralogs for RPL14 Gene

genes like me logo Genes that share paralogs with RPL14: view

No data available for Paralogs for RPL14 Gene

Variants for RPL14 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for RPL14 Gene

RL14_HUMAN-P50914
The poly-Ala stretch is highly polymorphic.

Sequence variations from dbSNP and Humsavar for RPL14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000744247 -- 40,455,376(+) CTAAA(G/T)AATAA upstream-variant-2KB
rs1002162982 -- 40,457,517(+) CCCTT(C/T)CCGGA intron-variant
rs1002236411 -- 40,457,401(+) CGACC(A/G)TGCCG intron-variant, utr-variant-5-prime
rs1002314769 -- 40,462,526(+) TGCCC(A/G)CCACC downstream-variant-500B
rs1002706607 -- 40,457,411(+) CTCGA(-/CCT)CCTCC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL14 Gene

Variant ID Type Subtype PubMed ID
nsv818137 CNV loss 17921354

Variation tolerance for RPL14 Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.11; 61.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL14

Disorders for RPL14 Gene

Relevant External Links for RPL14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL14

No disorders were found for RPL14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL14 Gene

Publications for RPL14 Gene

  1. Triplet repeat-containing ribosomal protein L14 gene in immortalized human endothelial cell line (t-HUE4). (PMID: 9480843) Tanaka M … Mitsui Y (Biochemical and biophysical research communications 1998) 2 3 4 22 60
  2. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova TI … Karpova GG (Journal of protein chemistry 2003) 3 4 22 60
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 3 4 60

Products for RPL14 Gene

Sources for RPL14 Gene

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