Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL14 Gene

protein-coding   GIFtS: 56
GCID: GC03P040501

ribosomal protein L14
 Explore 12 diseases affiliated with
RPL14 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RPL14    

Aliases
for RPL14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribosomal Protein L141 2     60S Ribosomal Protein L142
CTG-B331 2     CAG-ISL-72
L141 2     CAG-ISL 73
RL141 2     MMRPL325
HRL141     

External Ids:    HGNC: 103051   Entrez Gene: 90452   Ensembl: ENSG000001888467   OMIM: 6118275   UniProtKB: P509143   

Export aliases for RPL14 gene to outside databases

Previous GC identifers: GC03P039807 GC03P039727 GC03P040312 GC03P040459 GC03P040473


Summaries
for RPL14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPL14:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene
encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of
ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the
cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet
repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative
polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes
encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
(provided by RefSeq, Jul 2008)

Gene Wiki entry for RPL14 (60S ribosomal protein L14)


Genomic Views
for RPL14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL14 gene promoter:
         HEN1   E2F-1   E2F   Pax-4a   Nkx5-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPL14 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPL14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22-p21.2   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p22-p21.2

RPL14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL14 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P040501:  view genomic region     (about GC identifiers)

Start:
 40,498,783 bp from pter      End:
 40,503,861 bp from pter
Size:
 5,079 bases      Orientation:
 plus strand

Proteins
for RPL14 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RL14_HUMAN, P50914 (See protein sequence)
Recommended Name: 60S ribosomal protein L14  
Size: 215 amino acids; 23432 Da
Secondary accessions: Q45RF0 Q53G20 Q8TBD5 Q8WUT0 Q92579 Q96GR0 Q9BSB8 Q9BW65 Q9BYF6

Explore the universe of human proteins at neXtProt for RPL14: NX_P50914

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P50914

    • RPL14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001030168.1  NP_003964.3  

    ENSEMBL proteins: 
     ENSP00000345156   ENSP00000379506   ENSP00000391446   ENSP00000402476  
    Reactome Protein details: P50914
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): RPL14
    OriGene Protein Over-expression Lysate (see all 2): RPL14
    OriGene Custom Protein Services for RPL14 
    GenScript Custom Purified and Recombinant Proteins Services for RPL14
    Novus Biologicals RPL14 Proteins
    Novus Biologicals RPL14 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RPL14

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325


    RPL14 for ontologies           About GeneDecksing



    RPL14 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: RPL14
    OriGene Custom Antibody Services for RPL14 
    GenScript Custom Superior Antibodies Services for RPL14
    Novus Biologicals RPL14 Antibodies
    Search for Antibodies for RPL14 at Abcam  
    Uscn Antibodies for RPL14
    ThermoFisher Antibodies for RPL14

    Assay Products for RPL14: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RPL14
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RPL14

    Protein Domains /
    Families
    for RPL14 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RPL14 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002784 Ribosomal_L14
     IPR014722 Rib_L2_dom2

    Graphical View of Domain Structure for InterPro Entry P50914

    ProtoNet protein and cluster: P50914

    1 Blocks protein family: IPB002784 Ribosomal protein L14

    UniProtKB/Swiss-Prot: RL14_HUMAN, P50914
    Similarity: Belongs to the ribosomal protein L14e family


    Function
    for RPL14 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): RPL14
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPL14
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate RPL14:
    hsa-miR-3613-3p hsa-miR-548b-3p hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmid: RPL14 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL14 (see all 3)
    OriGene shRNA RFP: RPL14
    OriGene siRNA: RPL14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL14

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RPL14

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL14 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL14 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): RPL14 (NM_003973)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL14 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RPL14
    Search LifeMap BioReagents cell lines for RPL14

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPL14

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS9480843
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0005515protein binding IPI11369516


    RPL14 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for RPL14:
     Elongated cells  Increased gamma-H2AX phosphory  Nuclear 60S biogenesis defects  Nuclear pre-40S maturation def 


    Pathways & Interactions
    for RPL14 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    8/26 pathways (see all 26)
    		Viral Protein Synthesis1.00
    		Cytoplasmic Ribosomal Proteins0.86
    		Viral mRNA Translation1.00
    		CFTR translational fidelity (class I mutations)0.83
    		Influenza Viral RNA Transcription and Replication1.00
    		SMG6 Cleaves mRNA with Premature Termination Codon0.80
    		Synthesis of nascent polypeptide containing signal sequence1.00
    		L13a-mediated translational silencing of Ceruloplasmin expression0.79
    2Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    3Disease
    		Disease1.00
    4Generic Transcription Pathway
    		Gene Expression0.46
    5Asparagine N-linked glycosylation
    		Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL14
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL14 
        Cytoplasmic Ribosomal Proteins

    5/28        Reactome Pathways for RPL14 (see all 28)
        Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Eukaryotic Translation Initiation


    1         Kegg Pathway  (Kegg details for RPL14):
        Ribosome


    RPL14 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/303 Interacting proteins for RPL14 (P509141, 2, 3 ENSP000003451564) via UniProtKB, MINT, STRING, and/or I2D (see all 303)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL11P629132, 3, ENSP000003636764MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000363676
    RPL13P263732, 3, ENSP000003078894MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000307889
    RPL17-C18orf32P186212, 3MINT-6488590 MINT-6488791 I2D: score=1 
    RPL26P612542, 3, ENSP000002938424MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000293842
    RPL27AP467762, 3, ENSP000003460154MINT-6488590 MINT-6488791 I2D: score=1 STRING: ENSP00000346015
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006364rRNA processing IMP18697920
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--


    RPL14 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPL14 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPL14 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL14
    1 Novoseek chemical compound relationship for RPL14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alanine 26.4 1 9920051 (1)

    Search CenterWatch for drugs/clinical trials and news about RPL14 / RL14 

    Transcripts
    for RPL14 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPL14 gene (2 alternative transcripts): 
    NM_001034996.2  NM_003973.4  

    Unigene Cluster for RPL14:

    Ribosomal protein L14
    Hs.446522  [show with all ESTs]
    Unigene Representative Sequence: BF572302
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338970(uc003ckg.3) ENST00000465325 ENST00000396203(uc003ckh.3)
    ENST00000416518 ENST00000435633 ENST00000479563 ENST00000465280 ENST00000481798
    ENST00000461368

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): RPL14
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPL14
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate RPL14:
    hsa-miR-3613-3p hsa-miR-548b-3p hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmid: RPL14 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL14 (see all 3)
    OriGene shRNA RFP: RPL14
    OriGene siRNA: RPL14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL14
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL14 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL14 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): RPL14 (NM_003973)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL14 
    Primer
    Products:            		Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPL14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL14

    Additional cDNA sequence: 

    AK126111.1 AK222750.1 AK223111.1 AK290674.1 AK292045.1 AK300873.1 BC000606.2 BC005134.2 
    BC009294.2 BC016379.1 BC019651.1 BC022805.1 BC029036.1 BC071913.1 D87735.1 DQ118667.1 
    L10376.1 U16738.1 U92982.1 

    24/116 DOTS entries (see all 116):

    DT.91782889  DT.87011905  DT.100727687  DT.95212329  DT.95328639  DT.95370573  DT.120902869  DT.91931268 
    DT.100838985  DT.100838988  DT.91782989  DT.95370581  DT.91782830  DT.95370800  DT.100891055  DT.95221748 
    DT.97847984  DT.95224725  DT.95127987  DT.95365418  DT.92340075  DT.100838987  DT.100891027  DT.91782832 

    24/1840 AceView cDNA sequences (see all 1840):

    AA602717 BE041760 AI290962 AA172375 AW026636 F10621 CR618270 AA314365 
    BE167089 AW937226 BE070674 BF718555 BM806195 BE551411 AW877737 BE928687 
    AA186997 CR600213 BQ962472 BE076742 BG985952 BE070732 AW937222 BQ637894 

    GeneLoc Exon Structure


    Expression
    for RPL14 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGCTCACTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RPL14 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    Primitive StreakNotochordPrimitive Streak
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RPL14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL14

    SOURCE GeneReport for Unigene cluster: Hs.446522
        SABiosciences Custom PCR Arrays for RPL14
    Primer
    Products:    		Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPL14
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL14
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL14
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPL14

    Orthologs
    for RPL14 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL14 gene from 10/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rpl141 , 5 ribosomal protein L141, 5 85.58(n)1
    86.51(a)1    		   9 (71.74 cM)5
    671151  NM_025974.21  NP_080250.11 
     1205715175 
    chicken
    (Gallus gallus)    		 Aves RPL141 ribosomal protein L14 77.13(n)
    83.21(a)    		   374134  XM_418775.3  XP_418775.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RPL146
    		 --
    		 84(a)
    		 1 ↔ 1
    		 6(36031187-36034896)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CB592084.12   -- 78.82(n)    CB592084.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rpl141 ribosomal protein L14 71.78(n)
    71.53(a)    		   323365  NM_001002866.1  NP_001002866.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RpL141 Ribosomal protein L14 47.88(n)
    39.39(a)    		   38983  NM_079251.3  NP_523975.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rpl-141 Protein RPL-14 54.89(n)
    48.12(a)    		   172818  NM_060175.5  NP_492576.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RPL14A1 Rpl14ap 50.4(n)
    44.8(a)    		   853864   NP_012920.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G204501 60S ribosomal protein L14-1 54.87(n)
    46.15(a)    		   816564  NM_127604.3  NP_179635.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g05153001 hypothetical protein 53.79(n)
    46.21(a)    		   4336397  NM_001059845.1  NP_001053310.1 


    ENSEMBL Gene Tree for RPL14 (if available)
    TreeFam Gene Tree for RPL14 (if available) 

    Paralogs
    for RPL14 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL14 gene

    RPL14 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for RPL14 (see all 7)
    PGOHUM00000251027 PGOHUM00000240059 PGOHUM00000240902 PGOHUM00000250242 PGOHUM00000245711


    Genomic Variants
    for RPL14 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: RL14_HUMAN, P50914
    Polymorphism: The poly-Ala stretch is highly polymorphic


    10/184 NCBI SNPs in RPL14 are shown (see all 184)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs98588791,2
    		C,H,--40496944(+) GCTGAG/AGCAGA 2 -- us2k113Minor allele frequency- A:0.06NA WA CSA EA NS 523
    rs98590501,2
    		C,H,--40497076(+) TGGCCG/AAGCAC 2 -- us2k115Minor allele frequency- A:0.07NA WA CSA EA NS 507
    rs98590571,2
    		C,H,--40497082(+) AGCACG/AGTGGC 2 -- us2k111Minor allele frequency- A:0.05NA WA CSA EA 371
    rs98591851,2
    		C,H,--40497127(+) AGGCAG/AGTGAA 2 -- us2k113Minor allele frequency- A:0.04NA WA CSA EA NS 213
    rs1846735011,2
    		--40497214(+) CGGGCA/GTGGTG 2 -- us2k10--------
    rs1464229651,2
    		--40497244(+) GGTACG/TTGGGA 2 -- us2k10--------
    rs775887431,2
    		C--40497275(+) TGAACC/TCGGGA 2 -- us2k10--------
    rs749979481,2
    		C--40497276(+) GAACCA/CGGGAG 2 -- us2k10--------
    rs1120825021,2
    		--40497281(+) CGGGAG/AGCAGA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1480605131,2
    		C,--40497325(+) TGAGCC/TGAGAT 2 -- us2k11Minor allele frequency- T:0.01NS 134

    HapMap Linkage Disequilibrium report for RPL14 (40498783 - 40503861 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RPL14
         1 CNV: 9992

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL14
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL14

    Disorders / Diseases
    for RPL14 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RPL14 for disorders           About GeneDecksing

    OMIM gene information: 611827    OMIM disorders: --

    12 diseases for RPL14:    About MalaCards
    diamond-blackfan anemia    treacher collins syndrome    mucocutaneous leishmaniasis    myasthenic syndrome
    congenital myasthenic syndrome    squamous cell carcinoma    leishmaniasis    oral cancer
    anemia    carcinoma    pancreatitis    malaria

    1 disease from the University of Copenhagen DISEASES database for RPL14:
    Diamond-Blackfan anemia

    2 Novoseek disease relationships for RPL14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 23.2 3 16316724 (2), 9920051 (1)
    tumors 0 5 16316724 (4)


    Export disorders for RPL14 gene to outside databases

    Publications
    for RPL14 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL14 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with RPL14)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Triplet repeat-containing ribosomal protein L14 gene in immortalized human endothelial cell line (t-HUE4). (PubMed id 9480843)1, 2, 3, 9 Tanaka M.... Mitsui Y. (1998)
    2. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2, 9 Odintsova T.I....Karpova G.G. (2003)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (2002)
    6. A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. (PubMed id 11401437)1, 2 Uechi T.... Kenmochi N. (2001)
    7. Identification of trinucleotide repeat-containing genes in human pancreatic islets. (PubMed id 8549859)1, 2 Aoki M.... Permutt M.A. (1996)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    External Searches for RPL14 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RPL14 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9045 HGNC: 10305 AceView: RPL14 Ensembl:ENSG00000188846 euGenes: HUgn9045
    ECgene: RPL14 Kegg: 9045 H-InvDB: RPL14

    Other Databases showing RPL14 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RPL14 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL14 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RPL14 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RPL14 gene:
    Search GeneIP for patents involving RPL14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RPL14 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for RPL14   OriGene shRNA RFP for RPL14  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL14   Browse OriGene genome-wide validated SYBR primer pairs  
     OriGene Protein Over-expression Lysate for RPL14   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RPL14   OriGene 3'-UTR Clone for RPL14  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL14   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL14  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for RPL14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPL14   OriGene Custom Protein Services for RPL14  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPL14
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL14
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL14
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL14
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL14
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL14
     GenScript Custom Purified and Recombinant Proteins Services for RPL14 GenScript cDNA clones with any tag delivered in your preferred vector for RPL14
     GenScript Custom Assay Services for RPL14 GenScript Custom Superior Antibodies Services for RPL14
     GenScript Custom overexpressing Cell Line Services for RPL14 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RPL14 promoter
     Search Chromatin IP Primers for RPL14
     RT2 qPCR Primer Assay in human, mouse, rat RPL14
     Search GNC Networks for RPL14
     SABiosciences Custom PCR Arrays for RPL14
     Search Tocris compounds for RPL14
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RPL14 antibodies
     RPL14 proteins
     RPL14 lysates
     Search for Antibodies for RPL14 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RPL14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     RPL14 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RPL14
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPL14
     SwitchGear 3'UTR luciferase reporter plasmids for RPL14
     SwitchGear Promoter luciferase reporter plasmids for RPL14
     ThermoFisher Antibodies for RPL14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL14
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      RPL14 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4