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Aliases for RPL13A Gene

Aliases for RPL13A Gene

  • Ribosomal Protein L13a 2 3
  • Tissue Specific Transplantation Antigen 1 2 3
  • 23 KDa Highly Basic Protein 3 4
  • 60S Ribosomal Protein L13a 3
  • TSTA1 3
  • L13A 3

External Ids for RPL13A Gene

Previous HGNC Symbols for RPL13A Gene

  • TSTA1

Previous GeneCards Identifiers for RPL13A Gene

  • GC19P050649
  • GC19P050359
  • GC19P054666
  • GC19P054682
  • GC19P049991

Summaries for RPL13A Gene

Entrez Gene Summary for RPL13A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L13P family of ribosomal proteins that is a component of the 60S subunit. The encoded protein also plays a role in the repression of inflammatory genes as a component of the IFN-gamma-activated inhibitor of translation (GAIT) complex. This gene is co-transcribed with the small nucleolar RNA genes U32, U33, U34, and U35, which are located in the second, fourth, fifth, and sixth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for RPL13A Gene

RPL13A (Ribosomal Protein L13a) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL13A Gene

  • Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.

Gene Wiki entry for RPL13A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL13A Gene

Genomics for RPL13A Gene

Regulatory Elements for RPL13A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPL13A Gene

Start:
49,487,554 bp from pter
End:
49,492,308 bp from pter
Size:
4,755 bases
Orientation:
Plus strand

Genomic View for RPL13A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL13A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL13A Gene

Proteins for RPL13A Gene

  • Protein details for RPL13A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40429-RL13A_HUMAN
    Recommended name:
    60S ribosomal protein L13a
    Protein Accession:
    P40429
    Secondary Accessions:
    • A8K505

    Protein attributes for RPL13A Gene

    Size:
    203 amino acids
    Molecular mass:
    23577 Da
    Quaternary structure:
    • Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1.

    Three dimensional structures from OCA and Proteopedia for RPL13A Gene

neXtProt entry for RPL13A Gene

Proteomics data for RPL13A Gene at MOPED

Post-translational modifications for RPL13A Gene

  • Citrullinated by PADI4.
  • Phosphorylation at Ser-77 upon interferon-gamma treatment in monocytes involves a DAPK1-DAPK3 kinase cascade and is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.
  • Ubiquitination at Lys25, Lys51, Lys53, Lys103, Lys125, Lys134, Lys148, Lys159, and Lys191
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL13A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RPL13A (RPL13A)

No data available for DME Specific Peptides for RPL13A Gene

Domains for RPL13A Gene

Gene Families for RPL13A Gene

HGNC:
  • RPL :L ribosomal proteins

Protein Domains for RPL13A Gene

Graphical View of Domain Structure for InterPro Entry

P40429

UniProtKB/Swiss-Prot:

RL13A_HUMAN :
  • P40429
Family:
  • Belongs to the ribosomal protein L13P family.
genes like me logo Genes that share domains with RPL13A: view

Function for RPL13A Gene

Molecular function for RPL13A Gene

GENATLAS Biochemistry: 60S ribosomal protein L13-2
UniProtKB/Swiss-Prot Function: Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.

Gene Ontology (GO) - Molecular Function for RPL13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL13A: view
genes like me logo Genes that share phenotypes with RPL13A: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL13A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL13A Gene

Localization for RPL13A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL13A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL13A Gene COMPARTMENTS Subcellular localization image for RPL13A gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005730 nucleolus IDA 16791210
GO:0005737 cytoplasm IDA 16791210
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with RPL13A: view

Pathways for RPL13A Gene

genes like me logo Genes that share pathways with RPL13A: view

Pathways by source for RPL13A Gene

1 Cell Signaling Technology pathway for RPL13A Gene
1 BioSystems pathway for RPL13A Gene
1 KEGG pathway for RPL13A Gene
1 GeneGo (Thomson Reuters) pathway for RPL13A Gene

Gene Ontology (GO) - Biological Process for RPL13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL13A: view

Compounds for RPL13A Gene

(3) Drugbank Compounds for RPL13A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
target
ANISOMYCIN
target
PUROMYCIN
target
genes like me logo Genes that share compounds with RPL13A: view

Transcripts for RPL13A Gene

Unigene Clusters for RPL13A Gene

Ribosomal protein L13a:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL13A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL13A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d
SP1: - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - -
SP7: - - -
SP8: - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - -
SP12: -
SP13: - -
SP14:

Relevant External Links for RPL13A Gene

GeneLoc Exon Structure for
RPL13A
ECgene alternative splicing isoforms for
RPL13A

Expression for RPL13A Gene

mRNA expression in normal human tissues for RPL13A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL13A Gene

SOURCE GeneReport for Unigene cluster for RPL13A Gene Hs.523185

genes like me logo Genes that share expressions with RPL13A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL13A Gene

Orthologs for RPL13A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL13A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL13A 35
  • 100 (n)
  • 100 (a)
RPL13A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 83 (a)
OneToMany
RPL13A 35
  • 90.8 (n)
  • 97.04 (a)
RPL13A 36
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPL13A 35
  • 92.12 (n)
  • 99.51 (a)
RPL13A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl13a 35
  • 88.01 (n)
  • 95.57 (a)
Rpl13a 16
Rpl13a 36
  • 96 (a)
OneToMany
Rpl13a-ps1 36
  • 89 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPL13A 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL13A 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl13a 35
  • 87.19 (n)
  • 96.55 (a)
lizard
(Anolis carolinensis)
Reptilia RPL13A 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rpl13a-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl13a 35
  • 78.89 (n)
  • 91.46 (a)
Str.6691 35
zebrafish
(Danio rerio)
Actinopterygii Gstp1 35
rpl13a 35
  • 75.88 (n)
  • 87.44 (a)
rpl13a 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RpL13A 35
  • 63.65 (n)
  • 57.79 (a)
RpL13A 36
  • 56 (a)
OneToOne
CG1475 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-16 35
  • 59.15 (n)
  • 54.36 (a)
rpl-16 36
  • 52 (a)
OneToOne
rpl-16 37
  • 54 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER367C 35
  • 57.94 (n)
  • 56.54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL16A 36
  • 57 (a)
OneToMany
RPL16B 36
  • 55 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F04675g 35
  • 61.68 (n)
  • 65.87 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7126 35
soybean
(Glycine max)
eudicotyledons Gma.2053 35
barley
(Hordeum vulgare)
Liliopsida Hv.12482 35
corn
(Zea mays)
Liliopsida Zm.4020 35
wheat
(Triticum aestivum)
Liliopsida Ta.807 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01221 35
  • 62.22 (n)
  • 62.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl1601 35
  • 61.01 (n)
  • 66.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3458 36
  • 63 (a)
OneToOne
Species with no ortholog for RPL13A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL13A Gene

ENSEMBL:
Gene Tree for RPL13A (if available)
TreeFam:
Gene Tree for RPL13A (if available)

Paralogs for RPL13A Gene

Selected SIMAP similar genes for RPL13A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RPL13A: view

No data available for Paralogs for RPL13A Gene

Variants for RPL13A Gene

Sequence variations from dbSNP and Humsavar for RPL13A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs701717 -- 49,491,997(+) CTCGG(A/G)GAATT utr-variant-3-prime, nc-transcript-variant
rs1858742 -- 49,492,636(+) ATAAC(A/G)CTAGG downstream-variant-500B
rs1879266 -- 49,486,803(-) CTGGA(C/G)AAACC upstream-variant-2KB
rs2271951 -- 49,487,586(-) AGGGT(C/G/T)TCTTA utr-variant-5-prime, nc-transcript-variant
rs2271952 -- 49,487,536(-) TGCGC(A/G)GACGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL13A Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv912261 CNV Loss 21882294
nsv912262 CNV Loss 21882294
nsv912264 CNV Loss 21882294
nsv833862 CNV Loss 17160897
nsv912265 CNV Loss 21882294
nsv833863 CNV Loss 17160897

Relevant External Links for RPL13A Gene

HapMap Linkage Disequilibrium report
RPL13A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL13A Gene

Disorders for RPL13A Gene

Relevant External Links for RPL13A

Genetic Association Database (GAD)
RPL13A
Human Genome Epidemiology (HuGE) Navigator
RPL13A
genes like me logo Genes that share disorders with RPL13A: view

No data available for UniProtKB/Swiss-Prot for RPL13A Gene

Publications for RPL13A Gene

  1. Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control. (PMID: 14567916) Mazumder B. … Fox P.L. (Cell 2003) 3 4 23
  2. L13a blocks 48S assembly: role of a general initiation factor in mRNA-specific translational control. (PMID: 17218275) Kapasi P. … Mazumder B. (Mol. Cell 2007) 3 4 23
  3. Human ribosomal protein L13a is dispensable for canonical ribosome function but indispensable for efficient rRNA methylation. (PMID: 17921318) Chaudhuri S. … Mazumder B. (RNA 2007) 3 4 23
  4. DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. (PMID: 18995835) Mukhopadhyay R. … Fox P.L. (Mol. Cell 2008) 3 4 23
  5. Gene organization and sequence of the region containing the ribosomal protein genes RPL13A and RPS11 in the human genome and conserved features in the mouse genome. (PMID: 10580157) Higa S. … Kenmochi N. (Gene 1999) 3 4 23

Products for RPL13A Gene

Sources for RPL13A Gene

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