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Aliases for RPL13 Gene

Aliases for RPL13 Gene

  • Ribosomal Protein L13 2 3
  • Breast Basic Conserved Protein 1 3 4
  • BBC1 3 4
  • OK/SW-Cl.46 3
  • D16S444E 3
  • D16S44E 3
  • L13 3

External Ids for RPL13 Gene

Previous GeneCards Identifiers for RPL13 Gene

  • GC16P081509
  • GC16P090614
  • GC16P089330
  • GC16P089370
  • GC16P088154
  • GC16P089630
  • GC16P089631
  • GC16P075322
  • GC16P089633
  • GC16P089637
  • GC16P089650
  • GC16P089659
  • GC16P089669
  • GC16P089562

Summaries for RPL13 Gene

Entrez Gene Summary for RPL13 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2011]

GeneCards Summary for RPL13 Gene

RPL13 (Ribosomal Protein L13) is a Protein Coding gene. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL13 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL13 Gene

Genomics for RPL13 Gene

Regulatory Elements for RPL13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPL13 Gene

89,560,657 bp from pter
89,566,829 bp from pter
6,173 bases
Plus strand

Genomic View for RPL13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL13 Gene

Proteins for RPL13 Gene

  • Protein details for RPL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L13
    Protein Accession:
    Secondary Accessions:
    • B4DLX3
    • F5H1S2
    • Q3KQT8
    • Q567Q8
    • Q9BPX0

    Protein attributes for RPL13 Gene

    211 amino acids
    Molecular mass:
    24261 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL13 Gene

    Alternative splice isoforms for RPL13 Gene


neXtProt entry for RPL13 Gene

Proteomics data for RPL13 Gene at MOPED

Post-translational modifications for RPL13 Gene

  • Ubiquitination at Lys 123, Lys 174, and Lys 177
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL13 Gene

Domains & Families for RPL13 Gene

Protein Domains for RPL13 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L13e family.
  • Belongs to the ribosomal protein L13e family.
genes like me logo Genes that share domains with RPL13: view

No data available for Gene Families for RPL13 Gene

Function for RPL13 Gene

Molecular function for RPL13 Gene

GENATLAS Biochemistry:
60S ribosomal protein 13,underexpressed in hormone refractory prostate cancer

Gene Ontology (GO) - Molecular Function for RPL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9582194
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 17474147
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL13: view
genes like me logo Genes that share phenotypes with RPL13: view

miRNA for RPL13 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL13 Gene

Localization for RPL13 Gene

Subcellular locations from

Jensen Localization Image for RPL13 Gene COMPARTMENTS Subcellular localization image for RPL13 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for RPL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPL13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL13 Gene

Pathways & Interactions for RPL13 Gene

genes like me logo Genes that share pathways with RPL13: view

Pathways by source for RPL13 Gene

1 BioSystems pathway for RPL13 Gene
1 KEGG pathway for RPL13 Gene
1 GeneGo (Thomson Reuters) pathway for RPL13 Gene

Gene Ontology (GO) - Biological Process for RPL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL13: view

No data available for SIGNOR curated interactions for RPL13 Gene

Drugs & Compounds for RPL13 Gene

(2) Drugs for RPL13 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1792
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents, TNF-alpha synthesis inhibitor 776
genes like me logo Genes that share compounds with RPL13: view

Transcripts for RPL13 Gene

Unigene Clusters for RPL13 Gene

Ribosomal protein L13:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL13 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: -
SP4: - - - - - - -
SP5: -
SP6: - - - - -
SP7: - -
SP9: -
SP10: - -

Relevant External Links for RPL13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL13 Gene

mRNA expression in normal human tissues for RPL13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL13 Gene

This gene is overexpressed in Tlymphocyte (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL13 Gene

SOURCE GeneReport for Unigene cluster for RPL13 Gene Hs.410817

mRNA Expression by UniProt/SwissProt for RPL13 Gene

Tissue specificity: Higher levels of expression in benign breast lesions than in carcinomas
genes like me logo Genes that share expression patterns with RPL13: view

Protein tissue co-expression partners for RPL13 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RPL13 Gene

Orthologs for RPL13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL13 35
  • 90.21 (n)
  • 97.63 (a)
RPL13 36
  • 70 (a)
(Canis familiaris)
Mammalia RPL13 35
  • 89.57 (n)
  • 99.05 (a)
RPL13 36
  • 99 (a)
(Mus musculus)
Mammalia Rpl13 35
  • 86.89 (n)
  • 98.1 (a)
Rpl13 16
Rpl13 36
  • 98 (a)
Rpl13-ps3 36
  • 95 (a)
(Pan troglodytes)
Mammalia RPL13 35
  • 99.05 (n)
  • 99.53 (a)
RPL13 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rpl13 35
  • 86.1 (n)
  • 96.68 (a)
(Monodelphis domestica)
Mammalia RPL13 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia RPL13 36
  • 96 (a)
(Gallus gallus)
Aves RPL13 35
  • 79.94 (n)
  • 92.42 (a)
RPL13 36
  • 92 (a)
(Anolis carolinensis)
Reptilia RPL13 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75681 35
rpl13 35
  • 76.94 (n)
  • 89.1 (a)
(Danio rerio)
Actinopterygii rpl13 35
  • 76.94 (n)
  • 86.73 (a)
rpl13 36
  • 86 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL13 37
  • 62 (a)
RpL13 35
  • 64.84 (n)
  • 63.68 (a)
RpL13 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001805 35
  • 64.68 (n)
  • 62.19 (a)
(Caenorhabditis elegans)
Secernentea rpl-13 35
  • 60.84 (n)
  • 57.28 (a)
rpl-13 36
  • 57 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR257C 35
  • 54.55 (n)
  • 53.03 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22001g 35
  • 52.6 (n)
  • 51.76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL13B 35
  • 51.68 (n)
  • 52.53 (a)
RPL13A 36
  • 50 (a)
RPL13B 36
  • 51 (a)
RPL13A 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G23900 35
  • 54.39 (n)
  • 55.72 (a)
(Oryza sativa)
Liliopsida Os03g0576700 35
  • 56.22 (n)
  • 58.21 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05554 35
  • 55.93 (n)
  • 51.44 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl13 35
  • 58.33 (n)
  • 58.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7858 36
  • 64 (a)
Species with no ortholog for RPL13:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL13 Gene

Gene Tree for RPL13 (if available)
Gene Tree for RPL13 (if available)

Paralogs for RPL13 Gene

genes like me logo Genes that share paralogs with RPL13: view

No data available for Paralogs for RPL13 Gene

Variants for RPL13 Gene

Sequence variations from dbSNP and Humsavar for RPL13 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs258327 -- 89,562,810(+) CCTCC(A/G)GGTTC intron-variant
rs409413 -- 89,564,310(+) CATCT(A/T)AACAT utr-variant-3-prime
rs885268 -- 89,562,462(+) AGATG(C/G)GGGTG intron-variant
rs1062450 -- 89,562,914(+) TCATC(A/C/G)CTGAG reference, missense
rs3211567 -- 89,563,328(+) AGAGG(C/T)AAGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL13 Gene

Variant ID Type Subtype PubMed ID
nsv907357 CNV Loss 21882294
nsv428331 CNV Gain+Loss 18775914
dgv922e1 CNV Complex 17122850
nsv471118 CNV Gain 18288195
nsv907405 CNV Loss 21882294
dgv3008n71 CNV Loss 21882294
dgv3009n71 CNV Loss 21882294
nsv509639 CNV Insertion 20534489
dgv3010n71 CNV Loss 21882294
dgv3011n71 CNV Loss 21882294
esv2715169 CNV Deletion 23290073
esv994856 CNV Insertion 20482838

Variation tolerance for RPL13 Gene

Residual Variation Intolerance Score: 32.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.50; 71.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL13 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL13 Gene

Disorders for RPL13 Gene

Relevant External Links for RPL13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL13: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL13 Gene

Publications for RPL13 Gene

  1. The endocrine disruptor bisphenol A increases the expression of HSP70 and ecdysone receptor genes in the aquatic larvae of Chironomus riparius. (PMID: 18313723) PlanellA^ R. … Morcillo G. (Chemosphere 2008) 23 67
  2. Temperature sensitivity caused by mutant release factor 1 is suppressed by mutations that affect 16S rRNA maturation. (PMID: 15126466) Kaczanowska M. … RydAcn-Aulin M. (J. Bacteriol. 2004) 23 67
  3. All trans-retinoic acid (ATRA) elevated eukaryotic translation initiation factor 4A1 (eIF4A1) mRNA in ATRA-responsive vitiliginous epidermis. (PMID: 15541024) Lee A.Y. … Park S.W. (Pigment Cell Res. 2004) 23 67
  4. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 67
  5. The Drosophila melanogaster homologue of the human BBC1 gene is highly expressed during embryogenesis. (PMID: 7557437) Helps N.R. … Varley J.M. (Gene 1995) 23 67

Products for RPL13 Gene

Sources for RPL13 Gene

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