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Aliases for RPL12 Gene

Aliases for RPL12 Gene

  • Ribosomal Protein L12 2 3 5
  • 60S Ribosomal Protein L12 3
  • L12 3

External Ids for RPL12 Gene

Previous GeneCards Identifiers for RPL12 Gene

  • GC09M121324
  • GC09M121856
  • GC09M123663
  • GC09M125586
  • GC09M127289
  • GC09M129250
  • GC09M130209
  • GC09M099825

Summaries for RPL12 Gene

Entrez Gene Summary for RPL12 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL12 Gene

RPL12 (Ribosomal Protein L12) is a Protein Coding gene. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL12 Gene

  • Binds directly to 26S ribosomal RNA.

Gene Wiki entry for RPL12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL12 Gene

Genomics for RPL12 Gene

Regulatory Elements for RPL12 Gene

Enhancers for RPL12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F127448 1.2 ENCODE 45.4 +1.9 1902 7.5 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 RPL12 ZNF79 SNORA65 LOC102723566 ANGPTL2 URM1 ENSG00000230848 SLC2A8 NAIF1 ENG
GH09F127533 1.7 FANTOM5 Ensembl ENCODE 31.8 -89.0 -89018 13.7 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZNF143 FOS DEK ZNF263 SP5 RPL12 URM1 SNORA65 ENSG00000272593 ZNF79 ENSG00000272696 NAIF1 SLC2A8 LOC102723566 LOC100129352
GH09F127420 1.1 ENCODE 41.4 +28.2 28248 4.9 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 RPL12 CDK9 SLC2A8 ENSG00000272696 NAIF1 ENG SNORA65 LOC102723566 PTRH1 GC09M127421
GH09F127516 1.6 FANTOM5 Ensembl ENCODE 27.1 -70.1 -70075 9.3 PKNOX1 SIN3A FEZF1 ZNF2 GTF3C2 CBX5 ZNF143 FOS ZNF263 ZNF488 RPL12 SLC2A8 ZNF79 SNORA65 NAIF1 URM1 FAM129B CDK9 TOR2A SH2D3C
GH09F127416 1.1 Ensembl ENCODE 36.8 +33.3 33272 2.9 PKNOX1 SIN3A RAD21 ZNF121 RCOR1 FOS EGR2 USF2 ZNF217 MEF2D RPL12 SLC2A8 SNORA65 GARNL3 ENSG00000228487 CFAP157 TTC16 GC09M127421 PIR59639
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL12 on UCSC Golden Path with GeneCards custom track

Promoters for RPL12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPL12 Gene

127,447,674 bp from pter
127,451,432 bp from pter
3,759 bases
Minus strand

Genomic View for RPL12 Gene

Genes around RPL12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL12 Gene

Proteins for RPL12 Gene

  • Protein details for RPL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L12
    Protein Accession:
    Secondary Accessions:
    • Q5VVV2
    • Q6PB27

    Protein attributes for RPL12 Gene

    165 amino acids
    Molecular mass:
    17819 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL12 Gene

    Alternative splice isoforms for RPL12 Gene


neXtProt entry for RPL12 Gene

Post-translational modifications for RPL12 Gene

  • Ubiquitination at Lys 48, Lys 61, Lys 83, Lys 99, and Lys 130
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL12 Gene

Domains & Families for RPL12 Gene

Gene Families for RPL12 Gene

Suggested Antigen Peptide Sequences for RPL12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L11P family.
  • Belongs to the ribosomal protein L11P family.
genes like me logo Genes that share domains with RPL12: view

Function for RPL12 Gene

Molecular function for RPL12 Gene

GENATLAS Biochemistry:
60S ribosomal protein L12
UniProtKB/Swiss-Prot Function:
Binds directly to 26S ribosomal RNA.

Gene Ontology (GO) - Molecular Function for RPL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 22314232
GO:0019843 rRNA binding IBA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RPL12: view
genes like me logo Genes that share phenotypes with RPL12: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL12 Gene

Localization for RPL12 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL12 gene
Compartment Confidence
extracellular 5
cytosol 5
golgi apparatus 3
nucleus 2

Gene Ontology (GO) - Cellular Components for RPL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL12 Gene

Pathways & Interactions for RPL12 Gene

genes like me logo Genes that share pathways with RPL12: view

Pathways by source for RPL12 Gene

1 KEGG pathway for RPL12 Gene
1 GeneGo (Thomson Reuters) pathway for RPL12 Gene

SIGNOR curated interactions for RPL12 Gene

Other effect:

Gene Ontology (GO) - Biological Process for RPL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL12: view

Transcripts for RPL12 Gene

Unigene Clusters for RPL12 Gene

Ribosomal protein L12:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL12 Gene

No ASD Table

Relevant External Links for RPL12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL12 Gene

This gene is overexpressed in Tlymphocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL12 Gene

Protein tissue co-expression partners for RPL12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL12 Gene:


SOURCE GeneReport for Unigene cluster for RPL12 Gene:

genes like me logo Genes that share expression patterns with RPL12: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL12 Gene

Orthologs for RPL12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL12 35 35
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia RPL12 35
  • 96 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 95 (a)
-- 35
  • 82 (a)
(Canis familiaris)
Mammalia RPL12 34 35
  • 93.33 (n)
-- 35
  • 85 (a)
-- 35
  • 81 (a)
-- 35
  • 66 (a)
(Bos Taurus)
Mammalia RPL12 34 35 35
  • 91.52 (n)
(Rattus norvegicus)
Mammalia LOC102555453 34
  • 90.1 (n)
(Mus musculus)
Mammalia Rpl12 34 16 35
  • 89.49 (n)
(Gallus gallus)
Aves RPL12 34 35
  • 81.21 (n)
(Anolis carolinensis)
Reptilia RPL12 35
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl12 34
  • 80.61 (n)
Str.17078 34
African clawed frog
(Xenopus laevis)
Amphibia rpl12-prov 34
(Danio rerio)
Actinopterygii rpl12 34 35
  • 78.73 (n)
Dr.24686 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8947 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010065 34
  • 72.36 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL12 36 34 35
  • 70.12 (n)
(Caenorhabditis elegans)
Secernentea rpl-12 36 34 35
  • 69.11 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL12B 35
  • 70 (a)
RPL12A 34 35
  • 66.67 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR134W 34
  • 66.05 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A01903g 34
  • 64.83 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G37190 34
  • 62.58 (n)
(Glycine max)
eudicotyledons Gma.11290 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1323 34
(Oryza sativa)
Liliopsida Os04g0598200 34
  • 64.04 (n)
(Hordeum vulgare)
Liliopsida Hv.656 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8009 35
  • 75 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01317 34
  • 65.03 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl1201 34
  • 64.83 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3108 34
Species where no ortholog for RPL12 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL12 Gene

Gene Tree for RPL12 (if available)
Gene Tree for RPL12 (if available)

Paralogs for RPL12 Gene

(1) SIMAP similar genes for RPL12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPL12: view

No data available for Paralogs for RPL12 Gene

Variants for RPL12 Gene

Sequence variations from dbSNP and Humsavar for RPL12 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs111512199 -- 127,447,982(+) TCTTT(A/G/T)ATGGT reference, synonymous-codon
rs111718850 -- 127,449,715(+) TAGAA(A/G)TAAAG intron-variant, upstream-variant-2KB
rs112031868 -- 127,448,655(+) CCTTC(-/A)ACAAA intron-variant, upstream-variant-2KB
rs112361216 -- 127,447,892(+) TCCAC(A/G)GCACC reference, synonymous-codon
rs113212838 -- 127,447,677(+) AATCC(A/T)CCAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL12 Gene

Variant ID Type Subtype PubMed ID
nsv972452 CNV duplication 23825009

Variation tolerance for RPL12 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL12 Gene

Disorders for RPL12 Gene

Relevant External Links for RPL12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL12 Gene

Publications for RPL12 Gene

  1. The primary structure of human ribosomal protein L12. (PMID: 8441690) Chu W. … Burns D.K. (Nucleic Acids Res. 1993) 2 3 4 22 64
  2. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A. … Vieira A.R. (Am. J. Med. Genet. A 2010) 3 46 64
  3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 46 64
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64

Products for RPL12 Gene

Sources for RPL12 Gene

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