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Aliases for RPL12 Gene

Aliases for RPL12 Gene

  • Ribosomal Protein L12 2 3 5
  • L12 3

External Ids for RPL12 Gene

Previous GeneCards Identifiers for RPL12 Gene

  • GC09M121324
  • GC09M121856
  • GC09M123663
  • GC09M125586
  • GC09M127289
  • GC09M129250
  • GC09M130209
  • GC09M099825

Summaries for RPL12 Gene

Entrez Gene Summary for RPL12 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL12 Gene

RPL12 (Ribosomal Protein L12) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL12 Gene

  • Binds directly to 26S ribosomal RNA.

Gene Wiki entry for RPL12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL12 Gene

Genomics for RPL12 Gene

Regulatory Elements for RPL12 Gene

Enhancers for RPL12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPL12 on UCSC Golden Path with GeneCards custom track

Promoters for RPL12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL12 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL12 Gene

127,447,674 bp from pter
127,451,432 bp from pter
3,759 bases
Minus strand

Genomic View for RPL12 Gene

Genes around RPL12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL12 Gene

Proteins for RPL12 Gene

  • Protein details for RPL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L12
    Protein Accession:
    Secondary Accessions:
    • Q5VVV2
    • Q6PB27

    Protein attributes for RPL12 Gene

    165 amino acids
    Molecular mass:
    17819 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL12 Gene

    Alternative splice isoforms for RPL12 Gene


neXtProt entry for RPL12 Gene

Proteomics data for RPL12 Gene at MOPED

Post-translational modifications for RPL12 Gene

  • Ubiquitination at Lys 48, Lys 61, Lys 83, Lys 99, and Lys 130
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL12 Gene

Domains & Families for RPL12 Gene

Gene Families for RPL12 Gene

Protein Domains for RPL12 Gene

Suggested Antigen Peptide Sequences for RPL12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L11P family.
  • Belongs to the ribosomal protein L11P family.
genes like me logo Genes that share domains with RPL12: view

Function for RPL12 Gene

Molecular function for RPL12 Gene

GENATLAS Biochemistry:
60S ribosomal protein L12
UniProtKB/Swiss-Prot Function:
Binds directly to 26S ribosomal RNA.

Gene Ontology (GO) - Molecular Function for RPL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22314232
genes like me logo Genes that share ontologies with RPL12: view
genes like me logo Genes that share phenotypes with RPL12: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL12 Gene

Localization for RPL12 Gene

Subcellular locations from

Jensen Localization Image for RPL12 Gene COMPARTMENTS Subcellular localization image for RPL12 gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 3
chloroplast 2

Gene Ontology (GO) - Cellular Components for RPL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005840 ribosome IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL12 Gene

Pathways & Interactions for RPL12 Gene

genes like me logo Genes that share pathways with RPL12: view

Pathways by source for RPL12 Gene

1 KEGG pathway for RPL12 Gene
1 GeneGo (Thomson Reuters) pathway for RPL12 Gene

SIGNOR curated interactions for RPL12 Gene

Other effect:

Gene Ontology (GO) - Biological Process for RPL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL12: view

Drugs & Compounds for RPL12 Gene

No Compound Related Data Available

Transcripts for RPL12 Gene

Unigene Clusters for RPL12 Gene

Ribosomal protein L12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL12 Gene

No ASD Table

Relevant External Links for RPL12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL12 Gene

mRNA expression in normal human tissues for RPL12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL12 Gene

This gene is overexpressed in Tlymphocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL12 Gene

SOURCE GeneReport for Unigene cluster for RPL12 Gene Hs.408054

genes like me logo Genes that share expression patterns with RPL12: view

Protein tissue co-expression partners for RPL12 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL12 Gene

Orthologs for RPL12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL12 35
  • 91.52 (n)
  • 100 (a)
RPL12 36
  • 100 (a)
RPL12 36
  • 100 (a)
(Canis familiaris)
Mammalia RPL12 35
  • 93.33 (n)
  • 100 (a)
-- 36
  • 66 (a)
-- 36
  • 85 (a)
-- 36
  • 81 (a)
RPL12 36
  • 86 (a)
(Mus musculus)
Mammalia Rpl12 35
  • 89.49 (n)
  • 99.39 (a)
Rpl12 16
Rpl12 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC102555453 35
  • 90.1 (n)
  • 99.39 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
-- 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia RPL12 36
  • 96 (a)
(Pan troglodytes)
Mammalia RPL12 36
  • 100 (a)
RPL12 36
  • 100 (a)
(Gallus gallus)
Aves RPL12 35
  • 81.21 (n)
  • 95.15 (a)
RPL12 36
  • 95 (a)
(Anolis carolinensis)
Reptilia RPL12 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl12 35
  • 80.61 (n)
  • 94.77 (a)
Str.17078 35
African clawed frog
(Xenopus laevis)
Amphibia rpl12-prov 35
(Danio rerio)
Actinopterygii Dr.24686 35
rpl12 35
  • 78.73 (n)
  • 90.8 (a)
rpl12 36
  • 90 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8947 35
fruit fly
(Drosophila melanogaster)
Insecta RpL12 37
  • 79 (a)
RpL12 35
  • 70.12 (n)
  • 79.88 (a)
RpL12 36
  • 79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010065 35
  • 72.36 (n)
  • 81.71 (a)
(Caenorhabditis elegans)
Secernentea rpl-12 37
  • 73 (a)
rpl-12 35
  • 69.11 (n)
  • 73.78 (a)
rpl-12 36
  • 73 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR134W 35
  • 66.05 (n)
  • 68.1 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A01903g 35
  • 64.83 (n)
  • 67.48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL12A 35
  • 66.67 (n)
  • 71.17 (a)
RPL12A 36
  • 70 (a)
RPL12B 36
  • 70 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G37190 35
  • 62.58 (n)
  • 69.94 (a)
(Glycine max)
eudicotyledons Gma.11290 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1323 35
(Hordeum vulgare)
Liliopsida Hv.656 35
(Oryza sativa)
Liliopsida Os04g0598200 35
  • 64.04 (n)
  • 67.88 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3108 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01317 35
  • 65.03 (n)
  • 71.78 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl1201 35
  • 64.83 (n)
  • 71.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8009 36
  • 75 (a)
Species with no ortholog for RPL12:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL12 Gene

Gene Tree for RPL12 (if available)
Gene Tree for RPL12 (if available)

Paralogs for RPL12 Gene

(1) SIMAP similar genes for RPL12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPL12: view

No data available for Paralogs for RPL12 Gene

Variants for RPL12 Gene

Sequence variations from dbSNP and Humsavar for RPL12 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1139400 -- 127,447,832(-) GGGCC(A/G)CCCAG intron-variant
rs1139401 -- 127,447,730(-) TTCCC(A/C)CAGCC intron-variant
rs113212838 -- 127,447,677(+) AATCC(A/T)CCAGT utr-variant-3-prime
rs199572941 -- 127,447,912(+) GTCAT(C/T)GATGA reference, missense
rs200477216 -- 127,447,695(+) TGATC(C/G)TTTAT utr-variant-3-prime

Variation tolerance for RPL12 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RPL12 Gene

Disorders for RPL12 Gene

Relevant External Links for RPL12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL12 Gene

Publications for RPL12 Gene

  1. The primary structure of human ribosomal protein L12. (PMID: 8441690) Chu W. … Burns D.K. (Nucleic Acids Res. 1993) 2 3 4 23 67
  2. Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11. (PMID: 11809816) Plafker S.M. … Macara I.G. (Mol. Cell. Biol. 2002) 3 23
  3. Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. (PMID: 26561776) Verrastro I. … Pitt A.R. (Free Radic. Biol. Med. 2016) 3
  4. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  5. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. (PMID: 25670202) Rashidian J. … Luo K. (Sci Signal 2015) 3

Products for RPL12 Gene

Sources for RPL12 Gene