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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL12 Gene

protein-coding   GIFtS: 56
GCID: GC09M130209

ribosomal protein L12
 Explore 6 diseases affiliated with
RPL12 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RPL12    

Aliases
for RPL12 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribosomal Protein L121 2
L121 2
60S Ribosomal Protein L122

External Ids:    HGNC: 103021   Entrez Gene: 61362   Ensembl: ENSG000001979587   OMIM: 1804755   UniProtKB: P300503   

Export aliases for RPL12 gene to outside databases

Previous GC identifers: GC09M121324 GC09M121856 GC09M123663 GC09M125586 GC09M127289 GC09M129250 GC09M099825


Summaries
for RPL12 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPL12:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene
encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of
ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is
co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal
proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: RL12_HUMAN, P30050
Function: Binds directly to 26S ribosomal RNA (By similarity)

Gene Wiki entry for RPL12


Genomic Views
for RPL12 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL12 gene promoter:
         Lmo2   AP-4   NF-E2 p45   LCR-F1   AREB6   FAC1   E2F-1   E2F   NF-E2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPL12 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPL12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q34

RPL12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL12 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M130209:  view genomic region     (about GC identifiers)

Start:
 130,209,953 bp from pter      End:
 130,213,684 bp from pter
Size:
 3,732 bases      Orientation:
 minus strand

Proteins
for RPL12 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RL12_HUMAN, P30050 (See protein sequence)
Recommended Name: 60S ribosomal protein L12  
Size: 165 amino acids; 17819 Da
Secondary accessions: Q5VVV2 Q6PB27
Alternative splicing: 2 isoforms:  P30050-1   P30050-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RPL12: NX_P30050

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P30050

    • RPL12 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000967.1  
    ENSEMBL proteins: 
     ENSP00000354739   ENSP00000441179  
    Reactome Protein details: P30050
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: RPL12
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    Novus Biologicals RPL12 Proteins
    Novus Biologicals RPL12 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RPL12

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0022625cytosolic large ribosomal subunit IDA12962325


    RPL12 for ontologies           About GeneDecksing



    RPL12 Antibody Products: 
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    Uscn ELISAs and CLIAs for RPL12

    Protein Domains /
    Families
    for RPL12 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RPL12 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020783 Ribosomal_L11_C
     IPR020784 Ribosomal_L11_N
     IPR020785 Ribosomal_L11_CS
     IPR000911 Ribosomal_L11

    Graphical View of Domain Structure for InterPro Entry P30050

    ProtoNet protein and cluster: P30050

    1 Blocks protein family: IPB000911 Ribosomal protein L11

    UniProtKB/Swiss-Prot: RL12_HUMAN, P30050
    Similarity: Belongs to the ribosomal protein L11P family


    Function
    for RPL12 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RL12_HUMAN, P30050
    Function: Binds directly to 26S ribosomal RNA (By similarity)

         Genatlas biochemistry entry for RPL12:
    60S ribosomal protein L12

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPL12
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL12 (see all 7)
    OriGene shRNA RFP: RPL12
    OriGene siRNA: RPL12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL12

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL12 (see all 4)
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    Cell Line
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    Search LifeMap BioReagents cell lines for RPL12

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPL12

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0003735structural constituent of ribosome NAS12962325


    RPL12 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for RPL12:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Nuclear 60S biogenesis defects 


    Pathways & Interactions
    for RPL12 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    8/26 pathways (see all 26)
    		Viral Protein Synthesis1.00
    		Cytoplasmic Ribosomal Proteins0.86
    		Viral mRNA Translation1.00
    		CFTR translational fidelity (class I mutations)0.83
    		Influenza Viral RNA Transcription and Replication1.00
    		SMG6 Cleaves mRNA with Premature Termination Codon0.80
    		Synthesis of nascent polypeptide containing signal sequence1.00
    		L13a-mediated translational silencing of Ceruloplasmin expression0.79
    2Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    3Disease
    		Disease1.00
    4Generic Transcription Pathway
    		Gene Expression0.46
    5Asparagine N-linked glycosylation
    		Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL12
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL12 
        Cytoplasmic Ribosomal Proteins

    5/28        Reactome Pathways for RPL12 (see all 28)
        Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Eukaryotic Translation Initiation


    1         Kegg Pathway  (Kegg details for RPL12):
        Ribosome


    RPL12 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/999 Interacting proteins for RPL12 (P300502, 3 ENSP000003547394) via UniProtKB, MINT, STRING, and/or I2D (see all 999)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL8P629172, 3, ENSP000002625844MINT-6542674 MINT-7945693 MINT-6489539 MINT-6488791 I2D: score=6 STRING: ENSP00000262584
    RPS3P233962, 3, ENSP000002785724MINT-6542674 MINT-7945693 MINT-6489539 MINT-6488791 I2D: score=3 STRING: ENSP00000278572
    RPS2P158802, 3, ENSP000003418854MINT-6542674 MINT-6489539 MINT-6488791 I2D: score=3 STRING: ENSP00000341885
    RPL11P629132, 3, ENSP000003636764MINT-6542674 MINT-6489539 MINT-6488791 I2D: score=2 STRING: ENSP00000363676
    RPL13P263732, 3, ENSP000003078894MINT-6542674 MINT-7945693 MINT-6488791 I2D: score=2 STRING: ENSP00000307889
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--


    RPL12 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPL12 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL12
    Search CenterWatch for drugs/clinical trials and news about RPL12 / RL12 

    Transcripts
    for RPL12 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPL12 gene: 
    NM_000976.3  

    Unigene Cluster for RPL12:

    Ribosomal protein L12
    Hs.408054  [show with all ESTs]
    Unigene Representative Sequence: AK057602
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361436(uc004bqy.2 uc004bqz.2) ENST00000497825 ENST00000497322
    ENST00000483598 ENST00000536368

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL12 (see all 7)
    OriGene shRNA RFP: RPL12
    OriGene siRNA: RPL12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL12
    Clone
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    GenScript: all cDNA clones in your preferred vector: RPL12 (NM_000976)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL12 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL12

    Additional cDNA sequence: 

    AB209471.1 AF037643.1 AK026526.1 AK057602.1 BC050644.1 BC059950.1 BC094831.1 BC105603.1 
    L06505.1 Y11159.1 

    24/68 DOTS entries (see all 68):

    DT.91776054  DT.102840335  DT.85102005  DT.100761060  DT.91926813  DT.91820395  DT.100697094  DT.100697088 
    DT.87005955  DT.451137  DT.121170817  DT.97824072  DT.120834983  DT.121170814  DT.121170824  DT.40269548 
    DT.91796906  DT.100697087  DT.121170700  DT.91776065  DT.100055123  DT.120836783  DT.120974178  DT.121640399 

    24/1708 AceView cDNA sequences (see all 1708):

    BM916082 CR615987 BM768894 F26763 BF307982 BM908272 CB110564 CD677543 
    R21908 BE892267 CF127236 BQ927315 BM474602 BQ216968 BQ083501 BG285988 
    BE394729 BI518791 BG490861 BI850373 CB110941 N68208 AJ705476 BU687831 

    GeneLoc Exon Structure


    Expression
    for RPL12 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACATCATCGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RPL12 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneMandibular CondyleBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)

    See RPL12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL12

    SOURCE GeneReport for Unigene cluster: Hs.408054
        SABiosciences Custom PCR Arrays for RPL12
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPL12

    Orthologs
    for RPL12 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL12 gene from 9/35 species (see all 35)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rpl121 , 5 ribosomal protein L121, 5 89.49(n)1
    99.39(a)1    		   2 (22.09 cM)5
    2692611  NM_009076.31  NP_033102.21 
     329615595 
    chicken
    (Gallus gallus)    		 Aves RPL121 ribosomal protein L12 81.01(n)
    95.15(a)    		   417264  XM_415539.3  XP_415539.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RPL126
    		 --
    		 83(a)
    		 1 ↔ 1
    		 GL344004.1(24795-34417)
    African clawed frog
    (Xenopus laevis)    		 Amphibia rpl12-prov2 ribosomal protein L12 88.49(n)    BC041240.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.246862 Danio rerio mRNA similar to ribosomal protein L12 (cDNA more 85.39(n)    BC049061.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RpL121 , 3 protein biosynthesis structural constituent
    of more3
    Ribosomal protein L121    		 79(a)3
    70.12(n)1
    79.88(a)1    		   60B73
    453291  NM_166656.11  NP_726413.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea rpl-121 , 3 Ribosomal protein L113
    Protein RPL-121    		 73(a)3
    69.11(n)1
    73.78(a)1    		   IV(13239848-13240729)3
    1782791  NM_070141.51  NP_502542.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G371901 60S ribosomal protein L12-1 62.58(n)
    69.94(a)    		   818295  NM_129275.2  NP_181256.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g05982001 hypothetical protein 64.04(n)
    67.88(a)    		   4336856  NM_001060276.2  NP_001053741.1 


    ENSEMBL Gene Tree for RPL12 (if available)
    TreeFam Gene Tree for RPL12 (if available) 

    Paralogs
    for RPL12 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL12 gene

    RPL12 for paralogs           About GeneDecksing


    5/46 Pseudogenes.org Pseudogenes for RPL12 (see all 46)
    PGOHUM00000238568 PGOHUM00000238602 PGOHUM00000238633 PGOHUM00000238824 PGOHUM00000242210


    Genomic Variants
    for RPL12 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/116 NCBI SNPs in RPL12 are shown (see all 116)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs759458691,2
    		--99828421(+) TAGTTA/GAGATA 3 -- us2k12Minor allele frequency- G:0.08CSA WA 119
    rs1174468911,2
    		C,F,--99828717(+) TCTCTA/GAGCCA 4 -- us2k11Minor allele frequency- G:0.02EA 120
    rs782831421,2
    		--99828788(+) GACACA/GTGGAG 4 -- us2k11Minor allele frequency- G:0.01WA 118
    rs125536261,2
    		H--99828874(+) GCTCAA/GGCCTA 4 -- us2k10--------
    rs38088331,2
    		C,--99829632(-) TGCAAC/TTTCCT 4 -- us2k1 ese35Minor allele frequency- T:0.07MN EA NA 1376
    rs1164989021,2
    		C,F,--99829805(+) GCTGGC/TAAGCA 4 -- ut51 us2k12Minor allele frequency- T:0.07WA NS 246
    rs38088321,2
    		C,H--99829813(-) CGGTGC/TCCTGC 4 -- ut51 us2k14Minor allele frequency- T:0.00EA NS NA 384
    rs561417201,2
    		--99830588(+) ACGGAC/TGGGGG 4 -- int10--------
    rs1505276661,2
    		--130209512(+) TCATGA/GTAGTC 1 -- ds50010--------
    rs1395361111,2
    		--130209513(+) CATGAC/TAGTCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for RPL12 (130209953 - 130213684 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RPL12: --

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    Disorders / Diseases
    for RPL12 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RPL12 for disorders           About GeneDecksing

    OMIM gene information: 180475    OMIM disorders: --

    6 diseases for RPL12:    About MalaCards
    cleft lip/palate    treacher collins syndrome    cleft lip    intrahepatic cholangiocarcinoma
    cholangiocarcinoma    malaria

    Human Genome Epidemiology (HuGE) Navigator: RPL12 (2 documents)

    Export disorders for RPL12 gene to outside databases

    Publications
    for RPL12 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL12 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with RPL12)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The primary structure of human ribosomal protein L12. (PubMed id 8441690)1, 2, 3, 9 Chu W.... Burns D.K. (1993)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11. (PubMed id 11809816)1, 9 Plafker S.M. and Macara I.G. (2002)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
    10. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)

    External Searches for RPL12 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing RPL12 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6136 HGNC: 10302 AceView: RPL12 Ensembl:ENSG00000197958 euGenes: HUgn6136
    ECgene: RPL12 Kegg: 6136 H-InvDB: RPL12

    Other Databases showing RPL12 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RPL12 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL12 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RPL12 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RPL12 gene:
    Search GeneIP for patents involving RPL12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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