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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL10L Gene

protein-coding   GIFtS: 49
GCID: GC14M047120

ribosomal protein L10-like

 Explore 2 diseases affiliated with
RPL10L via our new
 Human Malady Compendium 
Biological research products
for RPL10L
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ribosomal Protein L10-Like1 2
60S Ribosomal Protein L10-Like2
RPL10_5_13582
Ribosomal Protein L10-Like Protein2

External Ids:    HGNC: 179761   Entrez Gene: 1408012   Ensembl: ENSG000001654967   UniProtKB: Q96L213   

Export aliases for RPL10L gene to outside databases

Previous GC identifers: GC14M044442 GC14M040916 GC14M045110 GC14M046189 GC14M027238


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL10L:
This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known whether
the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the
ribosome. This gene is intronless. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21
Function: May play a role in compensating for the inactivated X-linked gene during spermatogenesis

Gene Wiki entry for RPL10L


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL10L gene promoter:
         GR   STAT1   GR-beta   STAT1beta   RelA   NF-kappaB   LCR-F1   STAT1alpha   GR-alpha   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RPL10L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL10L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.2   Ensembl cytogenetic band:  14q21.2   HGNC cytogenetic band: 14q21.2

RPL10L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL10L gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M047120:  view genomic region     (about GC identifiers)

Start:
47,120,216 bp from pter      End:
47,121,028 bp from pter
Size:
813 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21 (See protein sequence)
Recommended Name: 60S ribosomal protein L10-like  
Size: 214 amino acids; 24519 Da
Miscellaneous: This gene has no introns in its coding regions, and therefore was most likely produced by
retrotransposition of the original X-linked gene during evolution
Secondary accessions: Q8IUD1

Explore the universe of human proteins at neXtProt for RPL10L: NX_Q96L21

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96L21

  • RPL10L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_542784.1  
    ENSEMBL proteins: 
     ENSP00000298283  

    Human Recombinant Protein Products: 
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    Novus Biologicals RPL10L Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RPL10L

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm ----
    GO:0022625cytosolic large ribosomal subunit NAS12490704


    RPL10L for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RPL10L for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001197 Ribosomal_L10e
     IPR016180 Ribosomal_L10e/L16
     IPR018255 Ribosomal_L10e_CS

    Graphical View of Domain Structure for InterPro Entry Q96L21

    ProtoNet protein and cluster: Q96L21

    1 Blocks protein family: IPB001197 Ribosomal protein L10E

    UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21
    Similarity: Belongs to the ribosomal protein L10e family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21
    Function: May play a role in compensating for the inactivated X-linked gene during spermatogenesis

    miRNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--


    RPL10L for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    Ribosome0.87

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for RPL10L):
        Ribosome


    RPL10L for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL10L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/140 Interacting proteins for RPL10L (Q96L212, 3 ENSP000002982834) via UniProtKB, MINT, STRING, and/or I2D (see all 140)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K14Q995582, 3MINT-48839 I2D: score=2 
    GABARAPL1Q9H0R83I2D: score=2 
    ATG14Q6ZNE53I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--
    GO:0007283spermatogenesis IEP12490704


    RPL10L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL10L

    3 DrugBank Compounds for RPL10L    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ANISOMYCIN-- --target--10592235
    Alpha-Hydroxy-Beta-Phenyl-Propionic Acid-- --target--10592235
    PUROMYCIN-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about RPL10L / RL10L 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPL10L gene: 
    NM_080746.2  

    Unigene Cluster for RPL10L:

    Ribosomal protein L10-like
    Hs.308332  [show with all ESTs]
    Unigene Representative Sequence: BU561557
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000298283(uc001wwg.3)

    miRNA
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    Additional cDNA sequence: 

    AB063608.1 AK130863.1 BC014310.1 BC066312.1 

    1 DOTS entry:

    DT.100035915 

    24/28 AceView cDNA sequences (see all 28):

    AB063608 AK130863 NM_080746 BX095190 BI561024 BC014310 BQ428774 BU569470 
    BP370342 BI559904 BG721101 BI825154 AI027614 BC066312 BI828161 BP368907 
    BQ441356 BU570130 BF979770 BU561178 AI223104 AI001784 BU561253 BF980074 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL10L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGGTCTGAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RPL10L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL10L

    SOURCE GeneReport for Unigene cluster: Hs.308332

    UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21
    Tissue specificity: Testis specific

        SABiosciences Custom PCR Arrays for RPL10L
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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPL10L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL10L gene from 10/36 species (see all 36)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl10l1 , 5 ribosomal protein L10-like1, 5 83.96(n)1
    94.86(a)1
      12 (27.44 cM)5
    2382171  NM_001162933.11  NP_001156405.11 
     662833815 
    chicken
    (Gallus gallus)
    Aves RPL10L1 ribosomal protein L10-like 77.37(n)
    91.74(a)
      396411  XM_003643539.1  XP_003643587.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    94(a)
    1 → many
    2(86474899-86478634)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.62152 Transcribed sequence with strong similarity to protein spP27635 (H.sapiens) RL10_HUMAN 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) less 82.15(n)    142018860 
    zebrafish
    (Danio rerio)
    Actinopterygii rpl106
    ribosomal protein L10
    87(a)
    1 → many
    23(20001107-20004409)
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL106
    Ribosomal protein L10
    74(a)
    1 → many
    3L(23086290-23088571)
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-101 Protein RPL-10 67.46(n)
    73.21(a)
      174311  NM_063306.4  NP_495707.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL101 Rpl10p 65.86(n)
    66.67(a)
      850764   NP_013176.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SAG241 60S ribosomal protein L10-3 64.56(n)
    68.93(a)
      842976  NM_105329.1  NP_564878.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01691001 hypothetical protein 64.08(n)
    68.93(a)
      4337928  NM_001061294.1  NP_001054759.1 


    ENSEMBL Gene Tree for RPL10L (if available)
    TreeFam Gene Tree for RPL10L (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL10L gene
    RPL102  
    1 SIMAP similar gene for RPL10L using alignment to 1 protein entry:     RL10L_HUMAN:
    RPL10

    RPL10L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/82 NCBI SNPs in RPL10L are shown (see all 82    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1479853411,2
    --47119810(+) AACAAC/TGTACA 1 -- ds50010--------
    rs1407416241,2
    --47119814(+) ATGTAC/TAGAAA 1 -- ds50010--------
    rs98060881,2
    C,F,H,--47119832(+) AAAAAC/TATAAG 1 -- ds500116Minor allele frequency- T:0.08NS EA NA WA 2176
    rs1136037031,2
    --47120049(+) CTAAAT/ATTAAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs125894511,2
    C,F,H,--47120056(+) TAAAGT/CGTTTG 1 -- ds50018Minor allele frequency- C:0.11NS EA NA WA 774
    rs1407456151,2
    C,--47120104(+) GAAGC-/AAAGGA 1 -- ds50010--------
    rs1389791631,2
    --47120133(+) AAACTC/GAATAA 1 -- ds50010--------
    rs755672221,2
    C,F,--47120249(+) TAAGCA/GTAAGT 1 -- ut311Minor allele frequency- G:0.02EA 120
    rs1443476601,2
    F--47120316(+) CGCCAC/TTTGTC 2 K syn11Minor allele frequency- T:0.00NA 4470
    rs2013209091,2
    --47120335(+) CATGAA/CTGGGA 2 S I mis10--------

    HapMap Linkage Disequilibrium report for RPL10L (47120216 - 47121028 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RPL10L
         1 CNV: 8769

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RPL10L for disorders           About GeneDecksing

    2 diseases for RPL10L:    About MalaCards
    malaria    ovarian cancer


    Export disorders for RPL10L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL10L gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with RPL10L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional second genes generated by retrotransposition of the X- linked ribosomal protein genes. (PubMed id 12490704)1, 2, 9 Uechi T.... Kenmochi N. (2002)
    2. Comparative analysis of processed ribosomal protein p seudogenes in four mammalian genomes. (PubMed id 19123937)1, 3 Balasubramanian S....Gerstein M. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    7. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Acetylation regulates gluconeogenesis by promoting PE PCK1 degradation via recruiting the UBR5 ubiquitin ligase. (PubMed id 21726808)1 Jiang W....Zhao S. (2011)
    10. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140801 HGNC: 17976 AceView: RPL10L Ensembl:ENSG00000165496 euGenes: HUgn140801
    ECgene: RPL10L Kegg: 140801 H-InvDB: RPL10L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL10L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPL10L gene:
    Search GeneIP for patents involving RPL10L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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