RPL10L Gene
protein-coding GIFtS : 49
GCID: GC14 M047120
ribosomal protein L10-like
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Aliasesfor RPL10L gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ribosomal Protein L10-Like 1 2 60S Ribosomal Protein L10-Like2 RPL10_5_13582 Ribosomal Protein L10-Like Protein2
Export aliases for RPL10L gene to outside databases Previous GC identifers: GC14M044442 GC14M040916 GC14M045110 GC14M046189 GC14M027238
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Summariesfor RPL10L gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for RPL10L : This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. This gene is intronless. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21 Function : May play a role in compensating for the inactivated X-linked gene during spermatogenesisGene Wiki entry for RPL10L
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Genomic Viewsfor RPL10L gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000014.8 NC_018925.1 NT_026437.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RPL10L gene promoter: GR STAT1 GR-beta STAT1beta RelA NF-kappaB LCR-F1 STAT1alpha GR-alpha NF-kappaB1 Other transcription factors Search SABiosciences Chromatin IP Primers for RPL10L Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL10L
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q21.2 Ensembl cytogenetic band: 14q21.2 HGNC cytogenetic band: 14q21.2 RPL10L Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14M047120: view genomic region
(about GC identifiers )
Start:
47,120,216 bp from pter
End:
47,121,028 bp from pter
Size:
813 bases
Orientation:
minus strand
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Proteinsfor RPL10L gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21 (See
protein sequence )Recommended Name: 60S ribosomal protein L10-like Size : 214 amino acids; 24519 Da
Miscellaneous : This gene has no introns in its coding regions, and therefore was most likely produced byretrotransposition of the original X-linked gene during evolution
Secondary accessions : Q8IUD1Explore the universe of human proteins at neXtProt for RPL10L: NX_Q96L21 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96L21 RPL10L Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_542784.1 ENSEMBL proteins: ENSP00000298283 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
RPL10L for ontologies About GeneDecksing RPL10L Antibody Products: Assay Products for RPL10L:
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Protein
Domains / Familiesfor RPL10L gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RPL10L for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q96L21 ProtoNet protein and cluster: Q96L21
1 Blocks protein family : IPB001197 Ribosomal protein L10E UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21 Similarity : Belongs to the ribosomal protein L10e family
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Functionfor RPL10L gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21 Function : May play a role in compensating for the inactivated X-linked gene during spermatogenesis
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPL10L (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPL10L (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RPL10L (NM_080746 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPL10L Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPL10L
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003735 structural constituent of ribosome
IEA --
RPL10L for ontologies About GeneDecksing
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Pathways & Interactionsfor RPL10L gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Synthesis of PB1-F2
Pathway sources See GeneCards unified pathways Show all pathways 1
Kegg Pathway (Kegg details for RPL10L) :
RPL10L for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL10L STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/140 Interacting proteins for RPL10L (Q96L21 2 , 3 ENSP00000298283 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 140 )About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
RPL10L for ontologies About GeneDecksing
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Drugs & Compoundsfor RPL10L gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RPL10L 3 DrugBank Compounds for RPL10L About this table Search CenterWatch for drugs/clinical trials and news about RPL10L / RL10L
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Transcriptsfor RPL10L gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RPL10L gene: NM_080746.2 Unigene Cluster for RPL10L:
Ribosomal protein L10-like Hs.308332 [show with all ESTs ] Unigene Representative Sequence: BU561557 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000298283 (uc001wwg.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPL10L (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPL10L (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RPL10L (NM_080746 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPL10L Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPL10L
Additional cDNA sequence: AB063608.1 AK130863.1 BC014310.1 BC066312.1
1 DOTS entry : DT.100035915
24/28 AceView cDNA sequences (see all 28 ):
AB063608 AK130863 NM_080746 BX095190 BI561024 BC014310 BQ428774 BU569470 BP370342 BI559904 BG721101 BI825154 AI027614 BC066312 BI828161 BP368907 BQ441356 BU570130 BF979770 BU561178 AI223104 AI001784 BU561253 BF980074 GeneLoc Exon Structure
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Expression for RPL10L gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RPL10L expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTGGTCTGAC
About this image See RPL10L Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPL10L SOURCE GeneReport for Unigene cluster: Hs.308332 UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21 Tissue specificity : Testis specific SABiosciences Custom PCR Arrays for RPL10L Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RPL10LBrowse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat RPL10L QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RPL10L QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RPL10L
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Orthologsfor RPL10L gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPL10L gene from 10/36 species (see all 36 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Rpl10l1 , 5
ribosomal protein L10-like1, 5
83.96(n) 1 94.86(a) 1
 
12 (27.44 cM) 5 238217 1 NM_001162933.1 1 NP_001156405.1 1 66283381 5
chicken (Gallus gallus)
Aves
RPL10L1
ribosomal protein L10-like
77.37(n) 91.74(a)
 
396411 XM_003643539.1 XP_003643587.1
lizard (Anolis carolinensis)
Reptilia
--
--
94(a)
1 → many
2(86474899-86478634)
tropical clawed frog (Xenopus tropicalis)
Amphibia
Str.62152
Transcribed sequence with strong similarity to protein spP27635 (H.sapiens) RL10_HUMAN 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) less
82.15(n)
 
142018860
zebrafish (Danio rerio)
Actinopterygii
rpl106
ribosomal protein L10
87(a)
1 → many
23(20001107-20004409)
fruit fly (Drosophila melanogaster)
Insecta
RpL106
Ribosomal protein L10
74(a)
1 → many
3L(23086290-23088571)
worm (Caenorhabditis elegans)
Secernentea
rpl-101
Protein RPL-10
67.46(n) 73.21(a)
 
174311 NM_063306.4 NP_495707.1
baker's yeast (Saccharomyces cerevisiae)
Saccharomycetes
RPL101
Rpl10p
65.86(n) 66.67(a)
 
850764 NP_013176.1
thale cress (Arabidopsis thaliana)
eudicotyledons
SAG241
60S ribosomal protein L10-3
64.56(n) 68.93(a)
 
842976 NM_105329.1 NP_564878.1
rice (Oryza sativa)
Liliopsida
Os05g01691001
hypothetical protein
64.08(n) 68.93(a)
 
4337928 NM_001061294.1 NP_001054759.1
ENSEMBL Gene Tree for RPL10L (if available)TreeFam Gene Tree for RPL10L (if available)
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Paralogsfor RPL10L gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RPL10L gene RPL10 2 1 SIMAP similar gene for RPL10L using alignment to 1 protein entry: RL10L_HUMAN :RPL10
RPL10L for paralogs About GeneDecksing
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Genomic Variantsfor RPL10L gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 14 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RPL10L (47120216 - 47121028 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for RPL10L 1 CNV : 8769
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RPL10L
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Disorders
/ Diseasesfor RPL10L gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
RPL10L for disorders About GeneDecksing 2 diseases for RPL10L : About MalaCards malaria ovarian cancer Export disorders for RPL10L gene to outside databases
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Publicationsfor RPL10L gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RPL10L gene, integrated from 9 sources (see all 21 ): (articles sorted by number of sources associating them with RPL10L) Utopia : connect your pdf to the dynamic world of online information
Functional second genes generated by retrotransposition of the X- linked ribosomal protein genes. (PubMed id 12490704) 1 , 2 , 9 Uechi T.... Kenmochi N. (2002) Comparative analysis of processed ribosomal protein p seudogenes in four mammalian genomes. (PubMed id 19123937) 1 , 3 Balasubramanian S....Gerstein M. (2009) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273) 1 Neganova I....Lako M. (2011) Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674) 1 Altun M....Kessler B.M. (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Acetylation regulates gluconeogenesis by promoting PE PCK1 degradation via recruiting the UBR5 ubiquitin ligase. (PubMed id 21726808) 1 Jiang W....Zhao S. (2011) Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590) 1 Emanuele M.J....Elledge S.J. (2011)
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External Searches for RPL10L gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RPL10L gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RPL10L gene
(According to HUGE )
About This Section --
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Specialized Databases showing RPL10L gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for RPL10L Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for RPL10L gene: Search GeneIP for patents involving RPL10L GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RPL10L gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for RPL10L OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for RPL10L OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RPL10L Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RPL10L OriGene 3'-UTR Clone for RPL10L OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPL10L OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPL10L Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RPL10L OriGene Custom Protein Services for RPL10L OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPL10L QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RPL10L QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL10L QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RPL10L QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RPL10L QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RPL10L
Search Tocris compounds for RPL10L
RPL10L Proteins, Antibodies, CLIAs, and ELISAs
Search ThermoFisher Antibodies for RPL10L
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPL10L
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Aliases for RPL10L
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Expression for RPL10L
Function for RPL10L
Genomic Views for RPL10L
Intellectual Property for RPL10L
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Products for RPL10L
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Summaries for RPL10L
Transcripts for RPL10L
Variants for RPL10L
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