Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPL10L Gene

Aliases for RPL10L Gene

  • Ribosomal Protein L10 Like 2 3 5
  • Ribosomal Protein L10-Like Protein 3
  • Ribosomal Protein L10-Like 2
  • RPL10_5_1358 3

External Ids for RPL10L Gene

Previous GeneCards Identifiers for RPL10L Gene

  • GC14M044442
  • GC14M040916
  • GC14M045110
  • GC14M046189
  • GC14M047120
  • GC14M027238

Summaries for RPL10L Gene

Entrez Gene Summary for RPL10L Gene

  • This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. This gene is intronless. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL10L Gene

RPL10L (Ribosomal Protein L10 Like) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL10.

UniProtKB/Swiss-Prot for RPL10L Gene

  • May play a role in compensating for the inactivated X-linked gene during spermatogenesis.

Gene Wiki entry for RPL10L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL10L Gene

Genomics for RPL10L Gene

Regulatory Elements for RPL10L Gene

Enhancers for RPL10L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPL10L on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL10L Gene

Chromosome:
14
Start:
46,651,010 bp from pter
End:
46,651,825 bp from pter
Size:
816 bases
Orientation:
Minus strand

Genomic View for RPL10L Gene

Genes around RPL10L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL10L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL10L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL10L Gene

Proteins for RPL10L Gene

  • Protein details for RPL10L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L21-RL10L_HUMAN
    Recommended name:
    60S ribosomal protein L10-like
    Protein Accession:
    Q96L21
    Secondary Accessions:
    • Q8IUD1

    Protein attributes for RPL10L Gene

    Size:
    214 amino acids
    Molecular mass:
    24519 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene has no introns in its coding regions, and therefore was most likely produced by retrotransposition of the original X-linked gene during evolution.

    Three dimensional structures from OCA and Proteopedia for RPL10L Gene

neXtProt entry for RPL10L Gene

Proteomics data for RPL10L Gene at MOPED

Post-translational modifications for RPL10L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPL10L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL10L Gene

Domains & Families for RPL10L Gene

Gene Families for RPL10L Gene

Protein Domains for RPL10L Gene

Suggested Antigen Peptide Sequences for RPL10L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96L21

UniProtKB/Swiss-Prot:

RL10L_HUMAN :
  • Belongs to the ribosomal protein L10e family.
Family:
  • Belongs to the ribosomal protein L10e family.
genes like me logo Genes that share domains with RPL10L: view

Function for RPL10L Gene

Molecular function for RPL10L Gene

UniProtKB/Swiss-Prot Function:
May play a role in compensating for the inactivated X-linked gene during spermatogenesis.

Phenotypes for RPL10L Gene

genes like me logo Genes that share phenotypes with RPL10L: view

Animal Model Products

miRNA for RPL10L Gene

miRTarBase miRNAs that target RPL10L

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL10L Gene

Localization for RPL10L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL10L Gene COMPARTMENTS Subcellular localization image for RPL10L gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for RPL10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005840 ribosome IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL10L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL10L Gene

Pathways & Interactions for RPL10L Gene

SuperPathways for RPL10L Gene

Superpath Contained pathways
1 Viral mRNA Translation
.60
genes like me logo Genes that share pathways with RPL10L: view

Pathways by source for RPL10L Gene

1 KEGG pathway for RPL10L Gene

Interacting Proteins for RPL10L Gene

Gene Ontology (GO) - Biological Process for RPL10L Gene

None

No data available for SIGNOR curated interactions for RPL10L Gene

Drugs & Compounds for RPL10L Gene

(3) Drugs for RPL10L Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
anisomycin Experimental Pharma Target JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL10L: view

Transcripts for RPL10L Gene

mRNA/cDNA for RPL10L Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPL10L Gene

Ribosomal protein L10-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL10L Gene

No ASD Table

Relevant External Links for RPL10L Gene

GeneLoc Exon Structure for
RPL10L
ECgene alternative splicing isoforms for
RPL10L

Expression for RPL10L Gene

mRNA expression in normal human tissues for RPL10L Gene

mRNA differential expression in normal tissues according to GTEx for RPL10L Gene

This gene is overexpressed in Testis (x50.6).

Protein differential expression in normal tissues from HIPED for RPL10L Gene

This gene is overexpressed in Liver (43.8) and Cervix (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RPL10L Gene



SOURCE GeneReport for Unigene cluster for RPL10L Gene Hs.308332

mRNA Expression by UniProt/SwissProt for RPL10L Gene

Q96L21-RL10L_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with RPL10L: view

Protein tissue co-expression partners for RPL10L Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RPL10L Gene

Orthologs for RPL10L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL10L Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Rpl10l 35
  • 83.96 (n)
  • 94.86 (a)
Rpl10l 16
Rpl10l 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPL10L 35
  • 99.22 (n)
  • 98.6 (a)
RPL10L 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl10l 35
  • 85.2 (n)
  • 94.86 (a)
cow
(Bos Taurus)
Mammalia RPL10L 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL10L 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
ManyToMany
-- 36
  • 93 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 93 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6215 35
zebrafish
(Danio rerio)
Actinopterygii rpl10 36
  • 87 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RpL10 36
  • 74 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rpl-10 35
  • 67.46 (n)
  • 73.21 (a)
rpl-10 36
  • 71 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL10 36
  • 62 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SAG24 35
  • 64.56 (n)
  • 68.93 (a)
soybean
(Glycine max)
eudicotyledons Gma.11225 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5792 35
barley
(Hordeum vulgare)
Liliopsida Hv.11026 35
rice
(Oryza sativa)
Liliopsida Os11g0220800 35
  • 65.38 (n)
  • 68.75 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11833 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3630 36
  • 75 (a)
OneToMany
Species with no ortholog for RPL10L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL10L Gene

ENSEMBL:
Gene Tree for RPL10L (if available)
TreeFam:
Gene Tree for RPL10L (if available)

Paralogs for RPL10L Gene

Paralogs for RPL10L Gene

(1) SIMAP similar genes for RPL10L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPL10L: view

Variants for RPL10L Gene

Structural Variations from Database of Genomic Variants (DGV) for RPL10L Gene

Variant ID Type Subtype PubMed ID
esv2751278 CNV Gain 17911159
dgv1920n71 CNV Loss 21882294
nsv901863 CNV Loss 21882294
nsv517764 CNV Loss 19592680

Variation tolerance for RPL10L Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL10L Gene

HapMap Linkage Disequilibrium report
RPL10L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RPL10L Gene

Disorders for RPL10L Gene

Relevant External Links for RPL10L

Genetic Association Database (GAD)
RPL10L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL10L

No disorders were found for RPL10L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL10L Gene

Publications for RPL10L Gene

  1. Functional second genes generated by retrotransposition of the X- linked ribosomal protein genes. (PMID: 12490704) Uechi T. … Kenmochi N. (Nucleic Acids Res. 2002) 3 4 23 67
  2. Comparative analysis of processed ribosomal protein pseudogenes in four mammalian genomes. (PMID: 19123937) Balasubramanian S. … Gerstein M. (Genome Biol. 2009) 2 3
  3. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for RPL10L Gene

Sources for RPL10L Gene

Content