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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL10L Gene

protein-coding   GIFtS: 50
GCID: GC14M047120

Ribosomal Protein L10-Like

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein L10-Like1 2
60S Ribosomal Protein L10-Like2
RPL10_5_13582
Ribosomal Protein L10-Like Protein2

External Ids:    HGNC: 179761   Entrez Gene: 1408012   Ensembl: ENSG000001654967   UniProtKB: Q96L213   

Export aliases for RPL10L gene to outside databases

Previous GC identifers: GC14M044442 GC14M040916 GC14M045110 GC14M046189 GC14M027238


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL10L Gene:
This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known
whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is
independent of the ribosome. This gene is intronless. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPL10L Gene: 
RPL10L (ribosomal protein L10-like) is a protein-coding gene. Diseases associated with RPL10L include ovarian cancer, and among its related super-pathways are Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL10.

UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21
Function: May play a role in compensating for the inactivated X-linked gene during spermatogenesis

Gene Wiki entry for RPL10L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL10L gene promoter:
         GR   STAT1   GR-beta   STAT1beta   RelA   NF-kappaB   LCR-F1   STAT1alpha   GR-alpha   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RPL10L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL10L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.2   Ensembl cytogenetic band:  14q21.2   HGNC cytogenetic band: 14q21.2

RPL10L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL10L gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M047120:  view genomic region     (about GC identifiers)

Start:
47,120,216 bp from pter      End:
47,121,028 bp from pter
Size:
813 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21 (See protein sequence)
Recommended Name: 60S ribosomal protein L10-like  
Size: 214 amino acids; 24519 Da
Miscellaneous: This gene has no introns in its coding regions, and therefore was most likely produced by
retrotransposition of the original X-linked gene during evolution
1 PDB 3D structure from and Proteopedia for RPL10L:
3J3B (3D)    
Secondary accessions: Q8IUD1

Explore the universe of human proteins at neXtProt for RPL10L: NX_Q96L21

Explore proteomics data for RPL10L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96L21

  • RPL10L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPL10L Protein Expression
    REFSEQ proteins: NP_542784.1  
    ENSEMBL proteins: 
     ENSP00000298283  

    Human Recombinant Protein Products for RPL10L: 
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    Cloud-Clone Corp. Proteins for RPL10L 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit NAS12490704

    RPL10L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RPL: L ribosomal proteins

    3 InterPro protein domains:
     IPR001197 Ribosomal_L10e
     IPR016180 Ribosomal_L10e/L16
     IPR018255 Ribosomal_L10e_CS

    Graphical View of Domain Structure for InterPro Entry Q96L21

    ProtoNet protein and cluster: Q96L21

    1 Blocks protein domain: IPB001197 Ribosomal protein L10E

    UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21
    Similarity: Belongs to the ribosomal protein L10e family


    RPL10L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RL10L_HUMAN, Q96L21
    Function: May play a role in compensating for the inactivated X-linked gene during spermatogenesis

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
         
    RPL10L for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPL10L About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Ribosome0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for RPL10L):
        Ribosome


    RPL10L for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL10L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/140 Interacting proteins for RPL10L (Q96L212, 3 ENSP000002982834) via UniProtKB, MINT, STRING, and/or I2D (see all 140)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K14Q995582, 3MINT-48839 I2D: score=2 
    GABARAPL1Q9H0R83I2D: score=2 
    ATG14Q6ZNE53I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--
    GO:0007283spermatogenesis IEP12490704

    RPL10L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL10L (RL10L)

    3 DrugBank Compounds for RPL10L    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ANISOMYCIN-- --target--10592235
    Alpha-Hydroxy-Beta-Phenyl-Propionic Acid-- --target--10592235
    PUROMYCIN-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about RPL10L / RL10L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPL10L gene: 
    NM_080746.2  

    Unigene Cluster for RPL10L:

    Ribosomal protein L10-like
    Hs.308332  [show with all ESTs]
    Unigene Representative Sequence: BU561557
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000298283(uc001wwg.3)
    miRNA
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    Additional mRNA sequence: 

    AB063608.1 AK130863.1 BC014310.1 BC066312.1 

    1 DOTS entry:

    DT.100035915 

    24/28 AceView cDNA sequences (see all 28):

    AB063608 AK130863 NM_080746 BX095190 BI561024 BG721101 BQ441356 BI828161 
    BC066312 BI559904 BP370342 BU569470 BI825154 BC014310 BQ428774 BF979770 
    BP368907 AI027614 BU570130 AI223104 BU561178 AI001784 BF980074 BU561253 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL10L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGTCTGAC
    RPL10L Expression
    About this image


    See RPL10L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL10L

    SOURCE GeneReport for Unigene cluster: Hs.308332

    UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21
    Tissue specificity: Testis specific

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL10L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL10L gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl10l1 , 5 ribosomal protein L10-like1, 5 83.96(n)1
    94.86(a)1
      12 (27.44 cM)5
    2382171  NM_001162933.11  NP_001156405.11 
     662833795 
    chicken
    (Gallus gallus)
    Aves RPL10L1 ribosomal protein L10-like 77.37(n)
    91.74(a)
      396411  XM_003643539.1  XP_003643587.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPL106
    Uncharacterized protein
    94(a)
    1 → many
    2(86474899-86478644)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.62152 Transcribed sequence with strong similarity to protein spP27635 (H.sapiens) RL10_HUMAN 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) less 82.15(n)    142018860 
    zebrafish
    (Danio rerio)
    Actinopterygii rpl106
    ribosomal protein L10
    87(a)
    possible ortholog
    23(20001107-20004409)
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL106
    Ribosomal protein L10
    74(a)
    1 → many
    3L(23086290-23088571)
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-101 Protein RPL-10 67.46(n)
    73.21(a)
      174311  NM_063306.4  NP_495707.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL101 Rpl10p 65.86(n)
    66.67(a)
      850764   NP_013176.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SAG241 60S ribosomal protein L10-3 64.56(n)
    68.93(a)
      842976  NM_105329.1  NP_564878.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01691001 hypothetical protein 64.08(n)
    68.93(a)
      4337928  NM_001061294.1  NP_001054759.1 


    ENSEMBL Gene Tree for RPL10L (if available)
    TreeFam Gene Tree for RPL10L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL10L gene
    RPL102  
    1 SIMAP similar gene for RPL10L using alignment to 1 protein entry:     RL10L_HUMAN:
    RPL10

    RPL10L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/109 SNPs in RPL10L are shown (see all 109)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1479853411,2
    --47119810(+) AACAAC/TGTACA 1 -- ds50010--------
    rs1407416241,2
    --47119814(+) ATGTAC/TAGAAA 1 -- ds50010--------
    rs98060881,2
    C,F,H--47119832(+) AAAAAC/TATAAG 1 -- ds500116Minor allele frequency- T:0.08NS EA NA WA 2176
    rs1136037031,2
    C,F--47120049(+) CTAAAT/ATTAAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs125894511,2
    C,F,H--47120056(+) TAAAGT/CGTTTG 1 -- ds50018Minor allele frequency- C:0.11NS EA NA WA 774
    rs1407456151,2
    C--47120104(+) GAAGC-/AAAGGA 1 -- ds50010--------
    rs1389791631,2
    --47120133(+) AAACTC/GAATAA 1 -- ds50010--------
    rs755672221,2
    C,F--47120249(+) TAAGCA/GTAAGT 1 -- ut311Minor allele frequency- G:0.02EA 120
    rs1443476601,2
    F--47120316(+) CGCCAC/TTTGTC 2 K syn11Minor allele frequency- T:0.00NA 4470
    rs2013209091,2
    --47120335(+) CATGAA/CTGGGA 2 S I mis10--------

    HapMap Linkage Disequilibrium report for RPL10L (47120216 - 47121028 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RPL10L:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1920n71CNV Loss21882294
    nsv901863CNV Loss21882294
    nsv517764CNV Loss19592680
    esv2751278CNV Gain17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for RPL10L:    About MalaCards
    ovarian cancer    


    RPL10L for disorders           About GeneDecksing

    Genetic Association Database (GAD): RPL10L

    Export disorders for RPL10L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL10L gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with RPL10L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional second genes generated by retrotransposition of the X- linked ribosomal protein genes. (PubMed id 12490704)1, 2, 9 Uechi T.... Kenmochi N. (2002)
    2. Comparative analysis of processed ribosomal protein p seudogenes in four mammalian genomes. (PubMed id 19123937)1, 3 Balasubramanian S....Gerstein M. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    8. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140801 HGNC: 17976 AceView: RPL10L Ensembl:ENSG00000165496 euGenes: HUgn140801
    ECgene: RPL10L Kegg: 140801 H-InvDB: RPL10L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL10L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPL10L gene:
    Search GeneIP for patents involving RPL10L

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