RPL10L Gene
protein-coding GIFtS: 49
GCID: GC14M047120
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|
ribosomal protein L10-like
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Aliases
for RPL10L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribosomal Protein L10-Like1 2 | | 60S Ribosomal Protein L10-Like2 | | RPL10_5_13582 | | Ribosomal Protein L10-Like Protein2 |
Export aliases for RPL10L gene to outside databasesPrevious GC identifers: GC14M044442 GC14M040916 GC14M045110 GC14M046189 GC14M027238 |
Summaries
for RPL10L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPL10L:
This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known whetherthe encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of theribosome. This gene is intronless. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21Function: May play a role in compensating for the inactivated X-linked gene during spermatogenesis
Gene Wiki entry for RPL10L
|
Genomic Views
for RPL10L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPL10L gene promoter:
GR STAT1 GR-beta STAT1beta RelA NF-kappaB LCR-F1 STAT1alpha GR-alpha NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPL10L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL10L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q21.2 Ensembl cytogenetic band: 14q21.2 HGNC cytogenetic band: 14q21.2RPL10L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M047120: view genomic region
(about GC identifiers)
Start:
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47,120,216 bp from pter |
End:
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47,121,028 bp from pter |
Size:
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813 bases |
Orientation:
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minus strand |
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Proteins
for RPL10L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21 (See
protein sequence)Recommended Name: 60S ribosomal protein L10-like Size: 214 amino acids; 24519 Da
Miscellaneous: This gene has no introns in its coding regions, and therefore was most likely produced byretrotransposition of the original X-linked gene during evolution
Secondary accessions: Q8IUD1Explore the universe of human proteins at neXtProt for RPL10L: NX_Q96L21
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96L21
RPL10L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_542784.1
ENSEMBL proteins: ENSP00000298283
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RPL10L for ontologies About GeneDecksing
RPL10L Antibody Products:
Assay Products for RPL10L: |
Protein
Domains /
Families
for RPL10L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPL10L for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96L21ProtoNet protein and cluster: Q96L21 1 Blocks protein family: IPB001197 Ribosomal protein L10E
UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21Similarity: Belongs to the ribosomal protein L10e family |
Function
for RPL10L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21Function: May play a role in compensating for the inactivated X-linked gene during spermatogenesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL10L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL10L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for RPL10L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL10L |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
IEA | -- |
RPL10L for ontologies About GeneDecksing
|
Pathways & Interactions
for RPL10L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for RPL10L):
RPL10L for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL10L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/140 Interacting proteins for RPL10L (Q96L212, 3 ENSP000002982834) via UniProtKB, MINT, STRING, and/or I2D (see all 140)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
RPL10L for ontologies About GeneDecksing
|
Drugs & Compounds
for RPL10L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RPL10L
3 DrugBank Compounds for RPL10L About this table
Search CenterWatch for drugs/clinical trials and news about RPL10L / RL10L
|
Transcripts
for RPL10L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPL10L gene: NM_080746.2 Unigene Cluster for RPL10L: Ribosomal protein L10-like Hs.308332 [show with all ESTs]Unigene Representative Sequence: BU5615571 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000298283(uc001wwg.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL10L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL10L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RPL10L (NM_080746) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPL10L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL10L |
Additional cDNA sequence: AB063608.1 AK130863.1 BC014310.1 BC066312.1 1 DOTS entry: DT.100035915 24/28 AceView cDNA sequences (see all 28): AB063608 AK130863 NM_080746 BX095190 BI561024 BC014310 BQ428774 BU569470 BP370342 BI559904 BG721101 BI825154 AI027614 BC066312 BI828161 BP368907 BQ441356 BU570130 BF979770 BU561178 AI223104 AI001784 BU561253 BF980074
GeneLoc Exon Structure
|
Expression
for RPL10L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPL10L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGTCTGAC
About this image
See RPL10L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPL10L
SOURCE GeneReport for Unigene cluster: Hs.308332
UniProtKB/Swiss-Prot: RL10L_HUMAN, Q96L21Tissue specificity: Testis specific
SABiosciences Custom PCR Arrays for RPL10L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPL10L
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat RPL10L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL10L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL10L |
Orthologs
for RPL10L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPL10L gene from 10/36 species (see all 36) About this table
ENSEMBL Gene Tree for RPL10L (if available)
TreeFam Gene Tree for RPL10L (if available) |
Paralogs
for RPL10L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RPL10L gene
- RPL102
1 SIMAP similar gene for RPL10L using alignment to 1 protein entry: RL10L_HUMAN:RPL10
RPL10L for paralogs About GeneDecksing
|
Genomic Variants
for RPL10L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RPL10L (47120216 - 47121028 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RPL10L
1 CNV: 8769 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL10L |
|
Disorders
/ Diseases
for RPL10L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPL10L for disorders About GeneDecksing
2  diseases for RPL10L: About MalaCardsmalaria ovarian cancer
Export disorders for RPL10L gene to outside databases
|
Publications
for RPL10L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPL10L gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with RPL10L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional second genes generated by retrotransposition of the X- linked ribosomal protein genes. (PubMed id 12490704)1, 2, 9 Uechi T.... Kenmochi N. (2002)
- Comparative analysis of processed ribosomal protein p seudogenes in four mammalian genomes. (PubMed id 19123937)1, 3 Balasubramanian S....Gerstein M. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
- Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Acetylation regulates gluconeogenesis by promoting PE PCK1 degradation via recruiting the UBR5 ubiquitin ligase. (PubMed id 21726808)1 Jiang W....Zhao S. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
|
External Searches for RPL10L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RPL10L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPL10L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPL10L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RPL10L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RPL10L gene:
Search GeneIP for patents involving RPL10L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPL10L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RPL10L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL10L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPL10L | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RPL10L | | OriGene 3'-UTR Clone for RPL10L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL10L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL10L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPL10L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL10L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL10L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL10L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL10L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL10L |
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 | | | RPL10L Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for RPL10L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL10L |
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