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Aliases for RPL10A Gene

Aliases for RPL10A Gene

  • Ribosomal Protein L10a 2 3 5
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 6 3 4
  • Large Ribosomal Subunit Protein UL1 3 4
  • Csa-19 3 4
  • NEDD-6 3 4
  • NEDD6 3 4
  • 60S Ribosomal Protein L10a 3
  • CSA19 3
  • L10a 3

External Ids for RPL10A Gene

Previous HGNC Symbols for RPL10A Gene

  • NEDD6

Previous GeneCards Identifiers for RPL10A Gene

  • GC06P035438
  • GC06P035483
  • GC06P035544
  • GC06P035156
  • GC06P035582
  • GC06P035784
  • GC06P036309
  • GC06P037295
  • GC06P035652
  • GC06P035663
  • GC06P037766
  • GC06P038390
  • GC06P038980

Summaries for RPL10A Gene

Entrez Gene Summary for RPL10A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL10A Gene

RPL10A (Ribosomal Protein L10a) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL10A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL10A Gene

Genomics for RPL10A Gene

Regulatory Elements for RPL10A Gene

Enhancers for RPL10A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G035467 1.4 ENCODE dbSUPER 29.1 +1.7 1739 5.4 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ENSG00000272374 RPL10A PPARD KCTD20 FANCE DEF6 UHRF1BP1 MIR7111
GH06G035451 1.3 ENCODE dbSUPER 21.1 -15.1 -15142 3.8 HDGF HNRNPUL1 MLX CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 RPL10A FANCE UHRF1BP1
GH06G035483 2.6 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10 +24.2 24161 18.1 CREB3L1 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ENSG00000272374 TEAD3 ENSG00000228559 FANCE RPL10A ENSG00000219023 TAF11 TULP1 UHRF1BP1 DEF6
GH06G034655 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -810.9 -810935 4.0 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 WRNIP1 ARID4B FEZF1 DMAP1 UHRF1BP1 LEMD2 ENSG00000220643 C6orf106 ENSG00000219023 FANCE RPS10 RPL10A TAF11 HMGA1
GH06G036439 1.8 FANTOM5 ENCODE dbSUPER 10.3 +974.4 974447 6.9 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ETV7 KCTD20 PXT1 LOC105375037 CDKN1A RPL10A PI16 MAPK14 SRSF3 BRPF3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL10A on UCSC Golden Path with GeneCards custom track

Promoters for RPL10A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000196090 499 1801 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for RPL10A Gene

Chromosome:
6
Start:
35,468,401 bp from pter
End:
35,470,785 bp from pter
Size:
2,385 bases
Orientation:
Plus strand

Genomic View for RPL10A Gene

Genes around RPL10A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL10A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL10A Gene

Proteins for RPL10A Gene

  • Protein details for RPL10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62906-RL10A_HUMAN
    Recommended name:
    60S ribosomal protein L10a
    Protein Accession:
    P62906
    Secondary Accessions:
    • B2R801
    • P52859
    • P53025
    • Q5TZT6
    • Q8J013

    Protein attributes for RPL10A Gene

    Size:
    217 amino acids
    Molecular mass:
    24831 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL10A Gene

neXtProt entry for RPL10A Gene

Post-translational modifications for RPL10A Gene

  • Ubiquitination at isoforms=106, Lys130, and Lys133
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL10A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL10A Gene

Domains & Families for RPL10A Gene

Gene Families for RPL10A Gene

Suggested Antigen Peptide Sequences for RPL10A Gene

Graphical View of Domain Structure for InterPro Entry

P62906

UniProtKB/Swiss-Prot:

RL10A_HUMAN :
  • Belongs to the universal ribosomal protein uL1 family.
Family:
  • Belongs to the universal ribosomal protein uL1 family.
genes like me logo Genes that share domains with RPL10A: view

Function for RPL10A Gene

Molecular function for RPL10A Gene

GENATLAS Biochemistry:
60S ribosomal protein L10A

Gene Ontology (GO) - Molecular Function for RPL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 24725412
genes like me logo Genes that share ontologies with RPL10A: view
genes like me logo Genes that share phenotypes with RPL10A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL10A Gene

Localization for RPL10A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL10A gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for RPL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0015934 large ribosomal subunit IEA --
genes like me logo Genes that share ontologies with RPL10A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL10A Gene

Pathways & Interactions for RPL10A Gene

genes like me logo Genes that share pathways with RPL10A: view

Pathways by source for RPL10A Gene

1 KEGG pathway for RPL10A Gene
1 GeneGo (Thomson Reuters) pathway for RPL10A Gene

Gene Ontology (GO) - Biological Process for RPL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000470 maturation of LSU-rRNA IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL10A: view

No data available for SIGNOR curated interactions for RPL10A Gene

Drugs & Compounds for RPL10A Gene

No Compound Related Data Available

Transcripts for RPL10A Gene

Unigene Clusters for RPL10A Gene

Ribosomal protein L10a:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL10A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - - - - - - -
SP6: -
SP7: - - - - -
SP8: - - -
SP9: -
SP10: - -

Relevant External Links for RPL10A Gene

GeneLoc Exon Structure for
RPL10A
ECgene alternative splicing isoforms for
RPL10A

Expression for RPL10A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL10A Gene



Protein tissue co-expression partners for RPL10A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL10A Gene:

RPL10A

SOURCE GeneReport for Unigene cluster for RPL10A Gene:

Hs.148340

Evidence on tissue expression from TISSUES for RPL10A Gene

  • Liver(4.9)
  • Nervous system(4.9)
  • Eye(4.8)
  • Lung(4.8)
  • Pancreas(4.8)
  • Skin(4.8)
  • Intestine(4.6)
  • Blood(4.5)
  • Stomach(4.4)
  • Muscle(4.3)
  • Kidney(3.9)
  • Heart(3.7)
  • Bone(3.5)
  • Spleen(2.6)
  • Lymph node(2.5)
  • Bone marrow(2.4)
  • Thyroid gland(2.4)
  • Adrenal gland(2.3)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with RPL10A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL10A Gene

Orthologs for RPL10A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL10A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL10A 34 35
  • 99.69 (n)
oppossum
(Monodelphis domestica)
Mammalia RPL10A 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 98 (a)
OneToMany
-- 35
  • 97 (a)
OneToMany
RPL10A 34
  • 90.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPL10A 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl10a-ps2 35
  • 90 (a)
OneToOne
Rpl10a 34 16
  • 89.09 (n)
dog
(Canis familiaris)
Mammalia RPL10A 34 35
  • 89.86 (n)
rat
(Rattus norvegicus)
Mammalia Rpl10a 34
  • 89.71 (n)
chicken
(Gallus gallus)
Aves RPL10A 34 35
  • 82.8 (n)
lizard
(Anolis carolinensis)
Reptilia RPL10A 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl10a 34
  • 78.4 (n)
Str.17067 34
African clawed frog
(Xenopus laevis)
Amphibia rpl10a-prov 34
zebrafish
(Danio rerio)
Actinopterygii rpl10a 34 35
  • 79.84 (n)
wufb94f08 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8350 34
fruit fly
(Drosophila melanogaster)
Insecta CG7283 36
  • 77 (a)
RpL10Ab 34 35
  • 71.74 (n)
CG3843 36
  • 57 (a)
RpL10Aa 35
  • 57 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011298 34
  • 73.12 (n)
worm
(Caenorhabditis elegans)
Secernentea Y71F9AL.13b 36
  • 75 (a)
rpl-1 36 34 35
  • 66.98 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL116W 34
  • 63.57 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02002g 34
  • 60.78 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL1A 35 37 34
  • 59.84 (n)
OneToMany
RPL1B 35
  • 59 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PGY1 34
  • 62.17 (n)
soybean
(Glycine max)
eudicotyledons Gma.6491 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7697 34
rice
(Oryza sativa)
Liliopsida Os02g0321900 34
  • 62.17 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.5459 34
wheat
(Triticum aestivum)
Liliopsida Ta.28647 34
corn
(Zea mays)
Liliopsida Zm.5240 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11350 35
  • 72 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU00294 34
  • 64.19 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl101 34
  • 61.55 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5227 34
Species where no ortholog for RPL10A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL10A Gene

ENSEMBL:
Gene Tree for RPL10A (if available)
TreeFam:
Gene Tree for RPL10A (if available)

Paralogs for RPL10A Gene

No data available for Paralogs for RPL10A Gene

Variants for RPL10A Gene

Sequence variations from dbSNP and Humsavar for RPL10A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs16876572 Likely benign 35,466,496(+) GCTGC(A/G/T)TAGGG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs559999264 Uncertain significance 35,466,667(+) AGGCT(C/T)GATCC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs886061333 Uncertain significance 35,466,746(+) TTGTA(C/G)ATAAT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs886061334 Uncertain significance 35,467,074(+) TATCA(A/G)TGGTG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs45584740 Benign 35,466,561(+) ATTTT(-/C)TTTTT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL10A Gene

Variant ID Type Subtype PubMed ID
nsv519370 CNV loss 19592680
nsv528351 CNV loss 19592680
nsv602910 CNV loss 21841781
nsv830641 CNV loss 17160897
nsv965717 CNV duplication 23825009

Variation tolerance for RPL10A Gene

Residual Variation Intolerance Score: 28.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL10A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL10A Gene

Disorders for RPL10A Gene

Relevant External Links for RPL10A

Genetic Association Database (GAD)
RPL10A
Human Genome Epidemiology (HuGE) Navigator
RPL10A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL10A

No disorders were found for RPL10A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL10A Gene

Publications for RPL10A Gene

  1. Identification of genes downregulated in the thymus by cyclosporin-A: preliminary characterization of clone CSA-19. (PMID: 7609734) Fisicaro N. … Pearse M. (Mol. Immunol. 1995) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova T.I. … Karpova G.G. (J. Protein Chem. 2003) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for RPL10A Gene

Sources for RPL10A Gene

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