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Aliases for RPL10A Gene

Aliases for RPL10A Gene

  • Ribosomal Protein L10a 2 3
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 6 3 4
  • Csa-19 3 4
  • NEDD-6 3 4
  • NEDD6 3 4
  • CSA19 3 6
  • 60S Ribosomal Protein L10a 3
  • L10A 3

External Ids for RPL10A Gene

Previous Symbols for RPL10A Gene

  • NEDD6

Summaries for RPL10A Gene

Entrez Gene Summary for RPL10A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL10A Gene

RPL10A (Ribosomal Protein L10a) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL10A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL10A Gene

Genomics for RPL10A Gene

Genomic Location for RPL10A Gene

Start:
35,468,401 bp from pter
End:
35,470,785 bp from pter
Size:
2,385 bases
Orientation:
Plus strand

Genomic View for RPL10A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL10A Gene

Regulatory Elements for RPL10A Gene

Proteins for RPL10A Gene

  • Protein details for RPL10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62906-RL10A_HUMAN
    Recommended name:
    60S ribosomal protein L10a
    Protein Accession:
    P62906
    Secondary Accessions:
    • B2R801
    • P52859
    • P53025
    • Q5TZT6
    • Q8J013

    Protein attributes for RPL10A Gene

    Size:
    217 amino acids
    Molecular mass:
    24831 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL10A Gene

neXtProt entry for RPL10A Gene

Proteomics data for RPL10A Gene at MOPED

Post-translational modifications for RPL10A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys106, Lys118, Lys130, and Lys133

Other Protein References for RPL10A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL10A Gene

Domains for RPL10A Gene

Gene Families for RPL10A Gene

HGNC:
  • RPL :L ribosomal proteins

UniProtKB/Swiss-Prot:

RL10A_HUMAN
Family:
  • Belongs to the ribosomal protein L1P family.:
    • P62906
genes like me logo Genes that share domains with RPL10A: view

Function for RPL10A Gene

Molecular function for RPL10A Gene

GENATLAS Biochemistry: 60S ribosomal protein L10A

Gene Ontology (GO) - Molecular Function for RPL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 24725412
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL10A: view
genes like me logo Genes that share phenotypes with RPL10A: view

miRNA for RPL10A Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL10A Gene

Localization for RPL10A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL10A Gene COMPARTMENTS Subcellular localization image for RPL10A gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for RPL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPL10A: view

Pathways for RPL10A Gene

genes like me logo Genes that share pathways with RPL10A: view

Pathways by source for RPL10A Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPL10A Gene
1 BioSystems pathway for RPL10A Gene

Gene Ontology (GO) - Biological Process for RPL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL10A: view

Transcripts for RPL10A Gene

Unigene Clusters for RPL10A Gene

Ribosomal protein L10a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL10A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - - - - - - -
SP6: -
SP7: - - - - -
SP8: - - -
SP9: -
SP10: - -

Relevant External Links for RPL10A Gene

GeneLoc Exon Structure for
RPL10A
ECgene alternative splicing isoforms for
RPL10A

Expression for RPL10A Gene

mRNA expression in normal human tissues for RPL10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL10A Gene

SOURCE GeneReport for Unigene cluster for RPL10A Gene Hs.148340

genes like me logo Genes that share expressions with RPL10A: view

Orthologs for RPL10A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL10A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL10A 36
  • 99.69 (n)
  • 100 (a)
RPL10A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 98 (a)
OneToMany
-- 37
  • 97 (a)
OneToMany
RPL10A 36
  • 90.32 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia RPL10A 36
  • 89.86 (n)
  • 100 (a)
RPL10A 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl10a 36
  • 89.09 (n)
  • 100 (a)
Rpl10a 16
Rpl10a-ps2 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPL10A 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL10A 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl10a 36
  • 89.71 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPL10A 36
  • 82.8 (n)
  • 94.47 (a)
RPL10A 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL10A 37
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rpl10a-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl10a 36
  • 78.4 (n)
  • 94.44 (a)
Str.17067 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8350 36
zebrafish
(Danio rerio)
Actinopterygii rpl10a 36
  • 79.84 (n)
  • 92.56 (a)
rpl10a 37
  • 92 (a)
OneToOne
wufb94f08 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011298 36
  • 73.12 (n)
  • 82.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL10Aa 37
  • 57 (a)
OneToMany
RpL10Ab 36
  • 71.74 (n)
  • 76.96 (a)
RpL10Ab 37
  • 77 (a)
OneToMany
CG7283 38
  • 77 (a)
CG3843 38
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-1 36
  • 66.98 (n)
  • 73.02 (a)
rpl-1 37
  • 73 (a)
OneToOne
rpl-1 38
  • 73 (a)
Y71F9AL.13b 38
  • 75 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL116W 36
  • 63.57 (n)
  • 62.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL1A 36
  • 59.84 (n)
  • 60 (a)
RPL1A 37
  • 59 (a)
OneToMany
RPL1A 39
RPL1B 37
  • 59 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02002g 36
  • 60.78 (n)
  • 62.79 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7697 36
soybean
(Glycine max)
eudicotyledons Gma.6491 36
thale cress
(Arabidopsis thaliana)
eudicotyledons PGY1 36
  • 62.17 (n)
  • 64.19 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.5459 36
corn
(Zea mays)
Liliopsida Zm.5240 36
rice
(Oryza sativa)
Liliopsida Os02g0321900 36
  • 62.17 (n)
  • 64.19 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28647 36
bread mold
(Neurospora crassa)
Ascomycetes NCU00294 36
  • 64.19 (n)
  • 63.72 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl101 36
  • 61.55 (n)
  • 64.65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5227 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11350 37
  • 72 (a)
OneToOne
Species with no ortholog for RPL10A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL10A Gene

ENSEMBL:
Gene Tree for RPL10A (if available)
TreeFam:
Gene Tree for RPL10A (if available)

Paralogs for RPL10A Gene

genes like me logo Genes that share paralogs with RPL10A: view

No data available for Paralogs for RPL10A Gene

Variants for RPL10A Gene

Sequence variations from dbSNP and Humsavar for RPL10A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3823432 -- 35,467,959(-) CTCGT(A/G)GTAAG upstream-variant-2KB
rs3823433 -- 35,467,816(-) TAAGG(C/T)GTCTA upstream-variant-2KB
rs41271257 -- 35,468,418(+) GGTTA(A/G)CGCGG utr-variant-5-prime
rs41345547 -- 35,467,959(-) ACTCG(A/G)GTAAG upstream-variant-2KB
rs45490693 -- 35,468,301(+) CGCTT(C/T)TCGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL10A Gene

Variant ID Type Subtype PubMed ID
nsv830641 CNV Loss 17160897
nsv528351 CNV Loss 19592680
nsv885799 CNV Loss 21882294
nsv519370 CNV Loss 19592680

Relevant External Links for RPL10A Gene

HapMap Linkage Disequilibrium report
RPL10A

Disorders for RPL10A Gene

Relevant External Links for RPL10A

Genetic Association Database (GAD)
RPL10A
Human Genome Epidemiology (HuGE) Navigator
RPL10A
genes like me logo Genes that share disorders with RPL10A: view

No data available for UniProtKB/Swiss-Prot for RPL10A Gene

Publications for RPL10A Gene

  1. Identification of genes downregulated in the thymus by cyclosporin-A: preliminary characterization of clone CSA-19. (PMID: 7609734) Fisicaro N. … Pearse M. (Mol. Immunol. 1995) 2 3 4
  2. Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex. (PMID: 9647638) Tripodis N. … Ragoussis J. (Genome Res. 1998) 2 3
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova T.I. … Karpova G.G. (J. Protein Chem. 2003) 3 4

Products for RPL10A Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RPL10A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RPL10A
    • Block miRNA regulation of RPL10A using miScript Target Protectors

    Sources for RPL10A Gene

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