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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL10 Gene

protein-coding   GIFtS: 64
GCID: GC0XP153618

ribosomal protein L10

 Explore 17 diseases affiliated with
RPL10 via our new
 Human Malady Compendium 
Biological research products
for RPL10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ribosomal Protein L101 2     Tumor Suppressor QM2 3
QM1 2 3 5     FLJ235441
DXS648E1 2 3     60S Ribosomal Protein L102
DXS6481 2 5     AUTSX52
L101 2     Wilms Tumor-Related Protein2
NOV1 2     Protein QM3
Laminin Receptor Homolog2 3     

External Ids:    HGNC: 102981   Entrez Gene: 61342   Ensembl: ENSG000001474037   OMIM: 3121735   UniProtKB: P276353   

Export aliases for RPL10 gene to outside databases

Previous GC identifers: GC0XP147690 GC0XP150007 GC0XP151212 GC0XP152096 GC0XP152097 GC0XP153147 GC0XP153279


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL10:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of
ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to
c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in
vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies
determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as
'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the
laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Alternative
splicing results in multiple transcript variants. This gene also uses multiple polyA signals, with the 3'-most polyA
signal overlapping the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the
small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal
proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Feb
2012)

Gene Wiki entry for RPL10


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL10 gene promoter:
         p53   AP-1   AML1a   AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL10 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPL10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

RPL10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL10 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP153618:  view genomic region     (about GC identifiers)

Start:
153,618,315 bp from pter      End:
153,637,504 bp from pter
Size:
19,190 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RL10_HUMAN, P27635 (See protein sequence)
Recommended Name: 60S ribosomal protein L10  
Size: 214 amino acids; 24604 Da
Subunit: Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit.
The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49
different proteins and 3 molecules of RNA (28S, 5.8S and 5S)
Developmental stage: Down-regulated during adipocyte, kidney, and heart differentiation
Sequence caution: Sequence=AAB22173.1; Type=Frameshift; Positions=124; Sequence=CAM45852.1; Type=Erroneous gene model
prediction; Sequence=CAM45853.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for RPL10:
2PA2 (3D)    
Secondary accessions: A3KQT0 D3DWW6 Q16470 Q2HXT7 Q53FH7 Q6FGN8 Q8TDA5

Explore the universe of human proteins at neXtProt for RPL10: NX_P27635

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P27635

  • RPL10 Protein expression data from MOPED and PaxDb:    About this image 
    RPL10 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001243506.1  NP_001243509.1  NP_006004.2  

    ENSEMBL proteins: 
     ENSP00000358832   ENSP00000388600   ENSP00000341730   ENSP00000395025   ENSP00000385621  
     ENSP00000406125   ENSP00000405064   ENSP00000407754   ENSP00000398047   ENSP00000413436  
    Reactome Protein details: P27635
    Human Recombinant Protein Products for RPL10: 
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    Uscn Proteins for RPL10

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA9443083

    RPL10 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RPL10 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001197 Ribosomal_L10e
     IPR016180 Ribosomal_L10e/L16
     IPR018255 Ribosomal_L10e_CS

    Graphical View of Domain Structure for InterPro Entry P27635

    ProtoNet protein and cluster: P27635

    1 Blocks protein family: IPB001197 Ribosomal protein L10E

    UniProtKB/Swiss-Prot: RL10_HUMAN, P27635
    Similarity: Belongs to the ribosomal protein L10e family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for RPL10:
    60S ribosomal protein L10

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS12962325
         
    RPL10 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RPL10:
     Decreased G3BP1 protein expres  Increased G2M DNA content  Nuclear 60S biogenesis defects  Nucleoplasmic pre-40S maturati 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    8/26 pathways (see all 26)
    Viral Protein Synthesis1.00
    Cytoplasmic Ribosomal Proteins0.86
    Viral mRNA Translation1.00
    CFTR translational fidelity (class I mutations)0.83
    Influenza Viral RNA Transcription and Replication1.00
    SMG6 Cleaves mRNA with Premature Termination Codon0.80
    Synthesis of nascent polypeptide containing signal sequence1.00
    L13a-mediated translational silencing of Ceruloplasmin expression0.79
    2Metabolism of mRNA
    Metabolism of mRNA1.00
    Metabolism of RNA0.92
    3Disease
    Disease1.00
    4Generic Transcription Pathway
    Gene Expression0.46
    5Asparagine N-linked glycosylation
    Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL10
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL10 
        Cytoplasmic Ribosomal Proteins

    5/28        Reactome Pathways for RPL10 (see all 28)
        Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Eukaryotic Translation Initiation


    1         Kegg Pathway  (Kegg details for RPL10):
        Ribosome


    RPL10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPL10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/350 Interacting proteins for RPL10 (P276352, 3 ENSP000003417304) via UniProtKB, MINT, STRING, and/or I2D (see all 350)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPL10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL10
    Search CenterWatch for drugs/clinical trials and news about RPL10 / RL10 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPL10 gene (3 alternative transcripts): 
    NM_001256577.1  NM_001256580.1  NM_006013.3  

    Unigene Cluster for RPL10:

    Ribosomal protein L10
    Hs.534404  [show with all ESTs]
    Unigene Representative Sequence: NM_006013
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474786 ENST00000369817 ENST00000479366 ENST00000436473 ENST00000344746(uc004fkn.1)
    ENST00000491035 ENST00000489200 ENST00000458500 ENST00000485196 ENST00000482732
    ENST00000492572 ENST00000467168 ENST00000406022 ENST00000451365(uc004fkq.1 uc004fkr.1)
    ENST00000427682 ENST00000449494 ENST00000428169 ENST00000424325(uc004fkm.2 uc004fko.2)


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    Additional cDNA sequence: 

    AB019572.1 AF486812.1 AK130582.1 AK223309.1 AK307511.1 AY927536.1 AY927570.1 AY927623.1 
    AY927624.1 BC003358.1 BC018570.1 BC026276.1 BC071918.1 BC095425.1 BX647954.1 CR456797.1 
    CR542069.1 M64241.1 M73791.1 S35960.1 X87196.1 

    24/175 DOTS entries (see all 175):

    DT.100846681  DT.121294714  DT.95325374  DT.100739701  DT.95202193  DT.85103592  DT.92071022  DT.100056570 
    DT.91865037  DT.121449274  DT.100739666  DT.92071218  DT.92412815  DT.91807241  DT.91840444  DT.121449218 
    DT.102841538  DT.100060476  DT.100739687  DT.121294698  DT.91965656  DT.92070886  DT.97870113  DT.101977215 

    24/2625 AceView cDNA sequences (see all 2625):

    BU558055 BM462151 AA381802 CD174977 BU521508 BQ427551 AI189284 BU956803 
    BM560546 BQ684334 AI192442 F34890 BQ641939 AA316837 BU182012 BQ644526 
    BM479606 AA318383 BQ642489 BI767150 BQ642727 BU172270 BU943992 BM806864 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RPL10 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b · 8c
    SP1:                                            -                                                                                 
    SP2:                                            -                             -     -     -     -                                 
    SP3:                                            -                             -     -     -     -     -     -                     
    SP4:                                            -                             -     -     -     -                                 
    SP5:                                            -                                                                                 


    ECgene alternative splicing isoforms for RPL10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGGCTTCCA
    RPL10 Expression
    About this image
    See RPL10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL10

    SOURCE GeneReport for Unigene cluster: Hs.534404
        SABiosciences Custom PCR Arrays for RPL10

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL10 gene from 7/32 species (see all 32)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    98(a)
    1 → many
    2(86474899-86478634)
    African clawed frog
    (Xenopus laevis)
    Amphibia rpl10-prov2 ribosomal protein L10 82.55(n)    BC044716.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa93d032 wufa93d03 83.25(n)   336712  BC045950.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Qm3
    RpL101
    protein biosynthesis structural constituent
    of ribosome less3
    Ribosomal protein L101
    78(a)3
    71.13(n)1
    78.95(a)1
      438641  NM_168984.41  NP_730773.41 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-103 ribosomal protein L10 (QM protein) 74(a)   II(8143691-8144574)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SAC526
    SAG246
    (see all 3)
    60S ribosomal protein L10-3
    (see all 3)
    66(a)
    66(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    1(4888214-4889661)
    1(24839165-24840612)
    rice
    (Oryza sativa)
    Liliopsida Os.101342 O.sativa SC34 mRNA for tumor suppressor 77.71(n)    AK103710.1 


    ENSEMBL Gene Tree for RPL10 (if available)
    TreeFam Gene Tree for RPL10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL10 gene
    RPL10L2  
    1 SIMAP similar gene for RPL10 using alignment to 8 protein entries:     RL10_HUMAN (see all proteins):
    RPL10L

    RPL10 for paralogs           About GeneDecksing


    5/43 Pseudogenes.org Pseudogenes for RPL10 (see all 43)
    PGOHUM00000242383 PGOHUM00000256671 PGOHUM00000242931 PGOHUM00000239511 PGOHUM00000239521


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/68 NCBI SNPs in RPL10 are shown (see all 68    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs66552871,2
    C,A--153624869(+) GCCACA/GGCGCC 3 -- us2k12Minor allele frequency- G:0.33NA CSA 3
    rs1137341161,2
    --153624872(+) ACAGCA/GCCCGG 3 -- us2k10--------
    rs1812623981,2
    --153625147(+) CCTCCC/GCCTCC 3 -- us2k10--------
    rs1869590121,2
    --153625429(+) GGCTCA/TAGTGA 3 -- us2k10--------
    rs1917415941,2
    --153625449(+) CTCCGC/TCCCTC 3 -- us2k10--------
    rs1819261731,2
    --153625540(+) CGAACC/TCAGTT 3 -- us2k10--------
    rs1861530381,2
    --153625658(+) TCCCAA/GGCTTT 3 -- us2k10--------
    rs1897353601,2
    --153625779(+) TTACCC/GCACCG 3 -- us2k10--------
    rs1494713541,2
    F--153625856(+) CTGCGC/AACCTC 3 -- us2k11Minor allele frequency- A:0.01NS 146
    rs1430320391,2
    F--153625926(+) CGCACC/TCGGAG 3 -- us2k11Minor allele frequency- T:0.01NS 150

    HapMap Linkage Disequilibrium report for RPL10 (153618315 - 153637504 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for RPL10
         2 Inversions: 0674 37365
    Human Gene Mutation Database (HGMD): RPL10

    Locus Specific Mutation Databases (LSDB): RPL10

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL10
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RPL10 for disorders           About GeneDecksing

    OMIM gene information: 312173    OMIM disorders: --

    UniProtKB/Swiss-Prot: RL10_HUMAN, P27635
  • Defects in RPL10 are a cause of susceptibility to autism X-linked type 5 (AUTSX5) [MIM:300847]. A complex
  • multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and
    communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental
    abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. Note=RPL10 is
    involved in autism only in rare cases. Two hypomorphic variants affecting the translation process have been found in
    families with autism spectrum disorders, suggesting that aberrant translation may play a role in disease mechanisms

    17 diseases for RPL10:    About MalaCards
    wilms tumor    pervasive developmental disorder    gonadal dysgenesis    treacher collins syndrome
    multiple endocrine neoplasia    autism spectrum disorder    premature ovarian failure    pancreatic endocrine tumors
    fanconi's anemia    anemia    prostate adenocarcinoma    ovarian cancer
    adenocarcinoma    pancreatitis    prostatitis    malaria
    carcinoma

    2 Novoseek disease relationships for RPL10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilms tumor 48.5 1 8789260 (1)
    tumors 0 5 12138090 (2), 19307926 (1)

    Human Genome Epidemiology (HuGE) Navigator: RPL10 (5 documents)

    Export disorders for RPL10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL10 gene, integrated from 9 sources (see all 79):
    (articles sorted by number of sources associating them with RPL10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (1998)
    2. QM, a putative tumor suppressor, regulates proto-oncogene c-Yes. (PubMed id 12138090)1, 2, 9 Oh H.S.... Yang C.-H. (2002)
    3. Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold. (PubMed id 18258260)1, 2, 9 Nishimura M....Kobayashi Y. (2008)
    4. Mutation and expression analyses of the ribosomal protein gene RPL10 in an extended German sample of patients with autism spectrum disorder. (PubMed id 21567917)1, 2 Chiocchetti A.... Klauck S.M. (2011)
    5. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1, 2 Meierhofer D.... Kaiser P. (2008)
    6. Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism. (PubMed id 16940977)1, 2 Klauck S.M.... Poustka A. (2006)
    7. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (2003)
    10. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PubMed id 8733135)1, 2 Chen E.Y....D'Urso M. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6134 HGNC: 10298 AceView: RPL10 Ensembl:ENSG00000147403 euGenes: HUgn6134
    ECgene: RPL10 Kegg: 6134 H-InvDB: RPL10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPL10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPL10 gene:
    Search GeneIP for patents involving RPL10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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