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Aliases for RPL10 Gene

Aliases for RPL10 Gene

  • Ribosomal Protein L10 2 3
  • Laminin Receptor Homolog 3 4
  • Tumor Suppressor QM 3 4
  • DXS648E 3 4
  • QM 3 4
  • Wilms Tumor-Related Protein 3
  • Protein QM 4
  • AUTSX5 3
  • DXS648 3
  • L10 3
  • NOV 3

External Ids for RPL10 Gene

Previous GeneCards Identifiers for RPL10 Gene

  • GC0XP147690
  • GC0XP150007
  • GC0XP151212
  • GC0XP152096
  • GC0XP152097
  • GC0XP153147
  • GC0XP153279
  • GC0XP153618

Summaries for RPL10 Gene

Entrez Gene Summary for RPL10 Gene

  • This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for RPL10 Gene

RPL10 (Ribosomal Protein L10) is a Protein Coding gene. Diseases associated with RPL10 include autism x-linked 5 and autism spectrum disorder. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome. An important paralog of this gene is RPL10L.

Gene Wiki entry for RPL10 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL10 Gene

Genomics for RPL10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPL10 Gene

Chromosome:
X
Start:
154,389,955 bp from pter
End:
154,409,168 bp from pter
Size:
19,214 bases
Orientation:
Plus strand

Genomic View for RPL10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL10 Gene

Proteins for RPL10 Gene

  • Protein details for RPL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27635-RL10_HUMAN
    Recommended name:
    60S ribosomal protein L10
    Protein Accession:
    P27635
    Secondary Accessions:
    • A3KQT0
    • D3DWW6
    • Q16470
    • Q2HXT7
    • Q53FH7
    • Q6FGN8
    • Q8TDA5

    Protein attributes for RPL10 Gene

    Size:
    214 amino acids
    Molecular mass:
    24604 Da
    Quaternary structure:
    • Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S)
    SequenceCaution:
    • Sequence=AAB22173.1; Type=Frameshift; Positions=124; Evidence={ECO:0000305}; Sequence=CAM45852.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM45853.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL10 Gene

neXtProt entry for RPL10 Gene

Proteomics data for RPL10 Gene at MOPED

Post-translational modifications for RPL10 Gene

  • Citrullinated by PADI4.
  • Ubiquitination at Lys 42, Lys 78, Lys 145, Lys 175, and Lys 188
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RPL10 Gene

Domains & Families for RPL10 Gene

Gene Families for RPL10 Gene

Protein Domains for RPL10 Gene

Graphical View of Domain Structure for InterPro Entry

P27635

UniProtKB/Swiss-Prot:

RL10_HUMAN :
  • Belongs to the ribosomal protein L10e family.
Family:
  • Belongs to the ribosomal protein L10e family.
genes like me logo Genes that share domains with RPL10: view

Function for RPL10 Gene

Molecular function for RPL10 Gene

GENATLAS Biochemistry:
60S ribosomal protein L10

Gene Ontology (GO) - Molecular Function for RPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 16741966
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL10: view
genes like me logo Genes that share phenotypes with RPL10: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL10 Gene

Localization for RPL10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL10 Gene COMPARTMENTS Subcellular localization image for RPL10 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for RPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL10 Gene

Pathways & Interactions for RPL10 Gene

genes like me logo Genes that share pathways with RPL10: view

Pathways by source for RPL10 Gene

1 Qiagen pathway for RPL10 Gene
1 Cell Signaling Technology pathway for RPL10 Gene
2 BioSystems pathways for RPL10 Gene
1 KEGG pathway for RPL10 Gene
1 GeneGo (Thomson Reuters) pathway for RPL10 Gene
1 R&D Systems pathway for RPL10 Gene

SIGNOR curated interactions for RPL10 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for RPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPL10: view

Drugs & Compounds for RPL10 Gene

No Compound Related Data Available

Transcripts for RPL10 Gene

Unigene Clusters for RPL10 Gene

Ribosomal protein L10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL10 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: -
SP6: -
SP7: - - - - -
SP8:
SP9: -
SP10: - - - - -
SP11: -
SP12:

Relevant External Links for RPL10 Gene

GeneLoc Exon Structure for
RPL10
ECgene alternative splicing isoforms for
RPL10

Expression for RPL10 Gene

mRNA expression in normal human tissues for RPL10 Gene

Protein differential expression in normal tissues from HIPED for RPL10 Gene

This gene is overexpressed in Nasal epithelium (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL10 Gene



SOURCE GeneReport for Unigene cluster for RPL10 Gene Hs.534404

genes like me logo Genes that share expression patterns with RPL10: view

Protein tissue co-expression partners for RPL10 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL10 Gene

Orthologs for RPL10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPL10 35
  • 90.65 (n)
  • 99.07 (a)
RPL10 36
  • 97 (a)
OneToMany
RPL10 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPL10 35
  • 91.43 (n)
  • 100 (a)
-- 36
  • 70 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Rpl10 35
  • 90.5 (n)
  • 100 (a)
Rpl10 16
Rpl10 36
  • 100 (a)
OneToMany
Rpl10-ps3 36
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RPL10 35
  • 98.91 (n)
  • 97.2 (a)
-- 36
  • 96 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Rpl10 35
  • 89.88 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
ManyToMany
-- 36
  • 86 (a)
ManyToMany
-- 36
  • 98 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 97 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia rpl10-prov 35
zebrafish
(Danio rerio)
Actinopterygii wufa93d03 35
rpl10 36
  • 90 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4144 35
fruit fly
(Drosophila melanogaster)
Insecta Qm 37
  • 78 (a)
RpL10 36
  • 75 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rpl-10 37
  • 74 (a)
rpl-10 36
  • 71 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL10 36
  • 63 (a)
OneToMany
RPL10 38
rice
(Oryza sativa)
Liliopsida Os.10134 35
corn
(Zea mays)
Liliopsida Zm.14596 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3630 36
  • 76 (a)
OneToMany
Species with no ortholog for RPL10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL10 Gene

ENSEMBL:
Gene Tree for RPL10 (if available)
TreeFam:
Gene Tree for RPL10 (if available)

Paralogs for RPL10 Gene

Paralogs for RPL10 Gene

(1) SIMAP similar genes for RPL10 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RPL10: view

Variants for RPL10 Gene

Sequence variations from dbSNP and Humsavar for RPL10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs6655287 -- 154,396,528(+) GCCAC(A/G)GCGCC upstream-variant-2KB
rs58419330 -- 154,396,740(+) TCTGA(A/G)ACGGA upstream-variant-2KB
rs61527699 -- 154,396,712(+) TATAT(A/T)TTTTT upstream-variant-2KB
rs111773609 -- 154,396,926(+) TGTTG(A/G)CCAGG upstream-variant-2KB
rs113734116 -- 154,396,531(+) ACAGC(A/G)CCCGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL10 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
esv33784 CNV Gain+Loss 17666407
nsv519042 CNV Gain 19592680
nsv7468 OTHER Inversion 18451855
nsv220 OTHER Inversion 15895083

Variation tolerance for RPL10 Gene

Residual Variation Intolerance Score: 58.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL10 Gene

HapMap Linkage Disequilibrium report
RPL10
Human Gene Mutation Database (HGMD)
RPL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL10 Gene

Disorders for RPL10 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RPL10 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
autism x-linked 5
  • autism, susceptibility to, x-linked 5
autism spectrum disorder
  • autism spectrum disorders
pervasive developmental disorder
  • pervasive development disorder
- elite association
Search RPL10 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RL10_HUMAN
  • Autism, X-linked 5 (AUTSX5) [MIM:300847]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. {ECO:0000269 PubMed:16940977, ECO:0000269 PubMed:21567917}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. RPL10 is involved in autism only in rare cases. Two hypomorphic variants affecting the translation process have been found in families with autism spectrum disorders, suggesting that aberrant translation may play a role in disease mechanisms.

Relevant External Links for RPL10

Genetic Association Database (GAD)
RPL10
Human Genome Epidemiology (HuGE) Navigator
RPL10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL10
genes like me logo Genes that share disorders with RPL10: view

No data available for Genatlas for RPL10 Gene

Publications for RPL10 Gene

  1. Proteomic analysis of rodent ribosomes revealed heterogeneity including ribosomal proteins L10-like, L22-like 1, and L39-like. (PMID: 20063902) Sugihara Y. … Nadano D. (J. Proteome Res. 2010) 23 67
  2. An investigation of ribosomal protein L10 gene in autism spectrum disorders. (PMID: 19166581) Gong X. … Bourgeron T. (BMC Med. Genet. 2009) 23 67
  3. Neurogenin 3 and neurogenic differentiation 1 are retained in the cytoplasm of multiple endocrine neoplasia type 1 islet and pancreatic endocrine tumor cells. (PMID: 19307926) Lejonklou M.H. … Skogseid B. (Pancreas 2009) 23 67
  4. Ribosomal protein L10 is encoded in the mitochondrial genome of many land plants and green algae. (PMID: 19917118) Mower J.P. … Bonen L. (BMC Evol. Biol. 2009) 23 67
  5. Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold. (PMID: 18258260) Nishimura M. … Kobayashi Y. (J. Mol. Biol. 2008) 23 67

Products for RPL10 Gene

Sources for RPL10 Gene

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