Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPL10 Gene

Aliases for RPL10 Gene

  • Ribosomal Protein L10 2 3 5
  • Large Ribosomal Subunit Protein UL16 3 4
  • Laminin Receptor Homolog 3 4
  • Tumor Suppressor QM 3 4
  • DXS648E 3 4
  • QM 3 4
  • Wilms Tumor-Related Protein 3
  • 60S Ribosomal Protein L10 3
  • Protein QM 4
  • AUTSX5 3
  • DXS648 3
  • L10 3
  • NOV 3

External Ids for RPL10 Gene

Previous GeneCards Identifiers for RPL10 Gene

  • GC0XP147690
  • GC0XP150007
  • GC0XP151212
  • GC0XP152096
  • GC0XP152097
  • GC0XP153147
  • GC0XP153279
  • GC0XP153618

Summaries for RPL10 Gene

Entrez Gene Summary for RPL10 Gene

  • This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for RPL10 Gene

RPL10 (Ribosomal Protein L10) is a Protein Coding gene. Diseases associated with RPL10 include Autism X-Linked 5 and X-Linked Intellectual Disability-Cerebellar Hypoplasia-Spondylo-Epiphyseal Dysplasia Syndrome. Among its related pathways are Viral mRNA Translation and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome. An important paralog of this gene is RPL10L.

Gene Wiki entry for RPL10 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL10 Gene

Genomics for RPL10 Gene

Regulatory Elements for RPL10 Gene

Enhancers for RPL10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG154443 0.9 ENCODE 12.8 +54.3 54272 2.3 HDGF HDAC1 RB1 ARNT CREB3L1 AGO1 ZSCAN4 SIN3A ZNF155 GLIS2 FAM50A HCFC1 LOC105373383 GDI1 LAGE3 UBL4A RPL10 PLXNA3 PDZD4 SNORA56
GH0XG154384 0.9 Ensembl dbSUPER 0.7 -4.9 -4855 1.8 CTCF ARID4B REST ZIC2 ZBTB7A RAD21 GLIS1 SCRT2 SMC3 ZBTB33 PLXNA3 RPL10 EMD
GH0XG154387 0.5 dbSUPER 0.7 -1.1 -1090 2.2 ZNF121 FOXA2 CEBPG ATF2 RPL10 EMD
GH0XG154389 0.5 dbSUPER 0.7 -2.3 -2339 0.6 ZNF121 CEBPG ATF2 RPL10 EMD
GH0XG154388 0.4 dbSUPER 0.7 -0.9 -941 1.8 FOXA2 CEBPG RPL10 EMD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL10 on UCSC Golden Path with GeneCards custom track

Promoters for RPL10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000249669 45 2401 FOXA2

Genomic Location for RPL10 Gene

Chromosome:
X
Start:
154,389,955 bp from pter
End:
154,409,168 bp from pter
Size:
19,214 bases
Orientation:
Plus strand

Genomic View for RPL10 Gene

Genes around RPL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL10 Gene

Proteins for RPL10 Gene

  • Protein details for RPL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27635-RL10_HUMAN
    Recommended name:
    60S ribosomal protein L10
    Protein Accession:
    P27635
    Secondary Accessions:
    • A3KQT0
    • D3DWW6
    • Q16470
    • Q2HXT7
    • Q53FH7
    • Q6FGN8
    • Q8TDA5

    Protein attributes for RPL10 Gene

    Size:
    214 amino acids
    Molecular mass:
    24604 Da
    Quaternary structure:
    • Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
    SequenceCaution:
    • Sequence=AAB22173.1; Type=Frameshift; Positions=124; Evidence={ECO:0000305}; Sequence=CAM45852.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM45853.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL10 Gene

neXtProt entry for RPL10 Gene

Post-translational modifications for RPL10 Gene

  • Citrullinated by PADI4.
  • Ubiquitination at isoforms=42, isoforms=78, Lys145, isoforms=175, and Lys188
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL10 Gene

Domains & Families for RPL10 Gene

Gene Families for RPL10 Gene

Protein Domains for RPL10 Gene

Graphical View of Domain Structure for InterPro Entry

P27635

UniProtKB/Swiss-Prot:

RL10_HUMAN :
  • Belongs to the universal ribosomal protein uL16 family.
Family:
  • Belongs to the universal ribosomal protein uL16 family.
genes like me logo Genes that share domains with RPL10: view

Function for RPL10 Gene

Molecular function for RPL10 Gene

GENATLAS Biochemistry:
60S ribosomal protein L10

Gene Ontology (GO) - Molecular Function for RPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0005515 protein binding IPI 10508860
genes like me logo Genes that share ontologies with RPL10: view
genes like me logo Genes that share phenotypes with RPL10: view

Human Phenotype Ontology for RPL10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL10 Gene

Localization for RPL10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL10 gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 4
extracellular 1

Gene Ontology (GO) - Cellular Components for RPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 10508860
GO:0005783 endoplasmic reticulum IDA --
GO:0005790 colocalizes_with smooth endoplasmic reticulum IDA 10508860
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPL10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL10 Gene

Pathways & Interactions for RPL10 Gene

genes like me logo Genes that share pathways with RPL10: view

Pathways by source for RPL10 Gene

1 KEGG pathway for RPL10 Gene
1 GeneGo (Thomson Reuters) pathway for RPL10 Gene

SIGNOR curated interactions for RPL10 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for RPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 10508860
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,IEA 12962325
genes like me logo Genes that share ontologies with RPL10: view

Transcripts for RPL10 Gene

Unigene Clusters for RPL10 Gene

Ribosomal protein L10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL10 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: -
SP6: -
SP7: - - - - -
SP8:
SP9: -
SP10: - - - - -
SP11: -
SP12:

Relevant External Links for RPL10 Gene

GeneLoc Exon Structure for
RPL10
ECgene alternative splicing isoforms for
RPL10

Expression for RPL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL10 Gene

Protein differential expression in normal tissues from HIPED for RPL10 Gene

This gene is overexpressed in Nasal epithelium (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL10 Gene



Protein tissue co-expression partners for RPL10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL10 Gene:

RPL10

SOURCE GeneReport for Unigene cluster for RPL10 Gene:

Hs.534404

Evidence on tissue expression from TISSUES for RPL10 Gene

  • Liver(5)
  • Nervous system(5)
  • Pancreas(4.9)
  • Intestine(4.8)
  • Lung(4.8)
  • Skin(4.8)
  • Eye(4.7)
  • Stomach(4.7)
  • Blood(4.6)
  • Muscle(4.6)
  • Heart(4.2)
  • Kidney(4.1)
  • Bone(3.8)
  • Thyroid gland(3.4)
  • Spleen(3.2)
  • Adrenal gland(2.6)
  • Bone marrow(2.6)
  • Gall bladder(2.6)
  • Lymph node(2.6)
genes like me logo Genes that share expression patterns with RPL10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL10 Gene

Orthologs for RPL10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL10 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Rpl10-ps3 35
  • 100 (a)
OneToMany
Rpl10 34 16 35
  • 90.5 (n)
chimpanzee
(Pan troglodytes)
Mammalia RPL10 34
  • 98.91 (n)
-- 35
  • 96 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 98 (a)
ManyToMany
-- 35
  • 90 (a)
ManyToMany
-- 35
  • 86 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPL10 34
  • 91.43 (n)
-- 35
  • 70 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia RPL10 34 35 35
  • 90.65 (n)
rat
(Rattus norvegicus)
Mammalia Rpl10 34
  • 89.88 (n)
chicken
(Gallus gallus)
Aves -- 35
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 97 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia rpl10-prov 34
zebrafish
(Danio rerio)
Actinopterygii rpl10 35
  • 90 (a)
OneToMany
wufa93d03 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4144 34
fruit fly
(Drosophila melanogaster)
Insecta Qm 36
  • 78 (a)
RpL10 35
  • 75 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rpl-10 36 35
  • 74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL10 35 37
  • 63 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.10134 34
corn
(Zea mays)
Liliopsida Zm.14596 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3630 35
  • 76 (a)
OneToMany
Species where no ortholog for RPL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL10 Gene

ENSEMBL:
Gene Tree for RPL10 (if available)
TreeFam:
Gene Tree for RPL10 (if available)

Paralogs for RPL10 Gene

Paralogs for RPL10 Gene

(1) SIMAP similar genes for RPL10 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RPL10: view

Variants for RPL10 Gene

Sequence variations from dbSNP and Humsavar for RPL10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_027795 Autism, X-linked 5 (AUTSX5) [MIM:300847]
VAR_027796 Autism, X-linked 5 (AUTSX5) [MIM:300847]
rs138325578 Uncertain significance 154,399,903(+) GTCAT(C/T)CGCAT upstream-variant-2KB, reference, synonymous-codon
rs369963498 Uncertain significance 154,400,856(+) ATGAG(A/G)GCTTC downstream-variant-500B, reference, missense, utr-variant-3-prime
rs12012747 other 154,400,814(+) CCCCA(A/G)TCGTG downstream-variant-500B, reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL10 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv33784 CNV gain+loss 17666407
nsv220 OTHER inversion 15895083
nsv481467 CNV novel sequence insertion 20440878
nsv519042 CNV gain 19592680
nsv7468 OTHER inversion 18451855

Variation tolerance for RPL10 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL10 Gene

Human Gene Mutation Database (HGMD)
RPL10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL10 Gene

Disorders for RPL10 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RPL10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search RPL10 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RL10_HUMAN
  • Autism, X-linked 5 (AUTSX5) [MIM:300847]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. {ECO:0000269 PubMed:16940977, ECO:0000269 PubMed:21567917}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. RPL10 is involved in autism only in rare cases. Two hypomorphic variants affecting the translation process have been found in families with autism spectrum disorders, suggesting that aberrant translation may play a role in disease mechanisms.

Relevant External Links for RPL10

Genetic Association Database (GAD)
RPL10
Human Genome Epidemiology (HuGE) Navigator
RPL10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL10
genes like me logo Genes that share disorders with RPL10: view

No data available for Genatlas for RPL10 Gene

Publications for RPL10 Gene

  1. An investigation of ribosomal protein L10 gene in autism spectrum disorders. (PMID: 19166581) Gong X. … Bourgeron T. (BMC Med. Genet. 2009) 3 22 46 64
  2. Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold. (PMID: 18258260) Nishimura M. … Kobayashi Y. (J. Mol. Biol. 2008) 3 4 22 64
  3. QM, a putative tumor suppressor, regulates proto-oncogene c-Yes. (PMID: 12138090) Oh H.S. … Yang C.-H. (J. Biol. Chem. 2002) 3 4 22 64
  4. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 64
  5. Mutation and expression analyses of the ribosomal protein gene RPL10 in an extended German sample of patients with autism spectrum disorder. (PMID: 21567917) Chiocchetti A. … Klauck S.M. (Am. J. Med. Genet. A 2011) 3 4 64

Products for RPL10 Gene

Sources for RPL10 Gene

Content
Loading form....