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RPH3AL Gene

protein-coding   GIFtS: 55
GCID: GC17M000062

Rabphilin 3A-Like (Without C2 Domains)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rabphilin 3A-Like (Without C2 Domains)1 2
NOC22 3 5
No C2 Domains Protein2 3
Rab Effector Noc22
Rabphilin-3A-Like Protein3

External Ids:    HGNC: 102961   Entrez Gene: 95012   Ensembl: ENSG000001810317   OMIM: 6048815   UniProtKB: Q9UNE23   

Export aliases for RPH3AL gene to outside databases

Previous GC identifers: GC17M000112 GC17M000100


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPH3AL Gene:
The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both
endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a
tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
(provided by RefSeq, Jun 2010)

GeneCards Summary for RPH3AL Gene:
RPH3AL (rabphilin 3A-like (without C2 domains)) is a protein-coding gene. Diseases associated with RPH3AL include miller-dieker syndrome, and lissencephaly. GO annotations related to this gene include LIM domain binding and Rab GTPase binding.

UniProtKB/Swiss-Prot: RPH3L_HUMAN, Q9UNE2
Function: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine
cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells

Gene Wiki entry for RPH3AL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_024972.9  NC_018928.2  NT_187662.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPH3AL gene promoter:
         SRF   SRF (504 AA)   p300   HSF1 (long)   AREB6   IRF-2   HSF1short   IRF-7A   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPH3AL promoter sequence
   Search Chromatin IP Primers for RPH3AL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPH3AL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

RPH3AL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPH3AL gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M000062:  view genomic region     (about GC identifiers)

Start:
62,180 bp from pter      End:
236,045 bp from pter
Size:
173,866 bases      Orientation:
minus strand

1 alternative location:
Chr17-,NW_003315952 62,180-220,466     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RPH3L_HUMAN, Q9UNE2 (See protein sequence)
Recommended Name: Rab effector Noc2  
Size: 315 amino acids; 34464 Da
Subunit: Recruited to dense-core vesicles through specific interaction with RAB27A in endocrine cells. Interacts
with RAB3A, RAB3B, RAB3C and RAB3D. Interacts with ZYX (By similarity)
Secondary accessions: D3DTG7 Q9BSB3
Alternative splicing: 2 isoforms:  Q9UNE2-1   Q9UNE2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RPH3AL: NX_Q9UNE2

Explore proteomics data for RPH3AL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RPH3AL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001177340.1  NP_001177341.1  NP_001177342.1  NP_008918.1  

    ENSEMBL proteins: 
     ENSP00000328977   ENSP00000319210   ENSP00000438224   ENSP00000460080   ENSP00000459795  
     ENSP00000459716   ENSP00000460580   ENSP00000459666   ENSP00000459992   ENSP00000459001  
     ENSP00000460171   ENSP00000461885   ENSP00000459975   ENSP00000458643  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR017455 Znf_FYVE-rel
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD
     IPR010911 Znf_FYVE-typ

    Graphical View of Domain Structure for InterPro Entry Q9UNE2

    ProtoNet protein and cluster: Q9UNE2

    1 Blocks protein domain: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: RPH3L_HUMAN, Q9UNE2
    Domain: The N-terminus of the RabBD domain is necessary and sufficient for interaction with RAB27A (By similarity)
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 1 RabBD (Rab-binding) domain


    RPH3AL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPH3L_HUMAN, Q9UNE2
    Function: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine
    cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells

         Genatlas biochemistry entry for RPH3AL:
    rabphillin 3A-like,ortholog of rat Rph3al,involved in regulated endocrine exocytosis,but not in the oncogenesis of
    medulloblastoma or other carcinomas

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008092cytoskeletal protein binding TAS9367993
    GO:0017137Rab GTPase binding IEA--
    GO:0030274LIM domain binding IEA--
    GO:0046872metal ion binding IEA--
         
    RPH3AL for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rph3al):
     digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism 

    RPH3AL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rph3altm1Sse for RPH3AL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPH3AL
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    miRNA
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    miRTarBase miRNAs that target RPH3AL:
    hsa-mir-16-5p (MIRT051146), hsa-mir-335-5p (MIRT018406)

    Block miRNA regulation of human, mouse, rat RPH3AL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPH3AL (see all 9):
    hsa-miR-892b hsa-miR-200a hsa-miR-520a-5p hsa-miR-141 hsa-miR-124 hsa-miR-525-5p hsa-miR-149 hsa-miR-3202
    SwitchGear 3'UTR luciferase reporter plasmidRPH3AL 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RPH3AL

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RPH3L_HUMAN, Q9UNE2: Cytoplasm. Cytoplasmic vesicle, secretory vesicle membrane. Note=Recruited to the vesicle
    membrane in a GTP- and RAB3B-dependent manner in epithelial cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS9367993
    GO:0030141secretory granule ----
    GO:0030658transport vesicle membrane IEA--
    GO:0030667secretory granule membrane IEA--

    RPH3AL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPH3AL About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    1 BioSystems Pathway for RPH3AL
        Deregulation of Rab and Rab Effector Genes in Bladder Cancer


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPH3AL
    Interactions:

        GeneGlobe Interaction Network for RPH3AL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for RPH3AL (Q9UNE23 ENSP000003192104) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB27BO001943, ENSP000002620944I2D: score=3 STRING: ENSP00000262094
    RAB26Q9ULW53, ENSP000002101874I2D: score=1 STRING: ENSP00000210187
    ZYXQ159423, ENSP000003244224I2D: score=1 STRING: ENSP00000324422
    RAB27AP511593, ENSP000003377614I2D: score=4 STRING: ENSP00000337761
    RAB3AP203363, ENSP000002222564I2D: score=5 STRING: ENSP00000222256
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006887exocytosis IEA--
    GO:0017158regulation of calcium ion-dependent exocytosis IEA--
    GO:0042493response to drug IEA--
    GO:0042593glucose homeostasis IEA--

    RPH3AL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPH3AL (RPH3L)

    1 HMDB Compound for RPH3AL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPH3AL gene (4 alternative transcripts): 
    NM_001190411.1  NM_001190412.1  NM_001190413.1  NM_006987.3  

    Unigene Cluster for RPH3AL:

    Rabphilin 3A-like (without C2 domains)
    Hs.651925  [show with all ESTs]
    Unigene Representative Sequence: BC005153
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000331302(uc010vpy.2 uc002fre.2 uc021tmx.1) ENST00000323434(uc002frf.2 uc010cjl.2)
    ENST00000572965 ENST00000536489 ENST00000572075 ENST00000570893 ENST00000576001
    ENST00000570954 ENST00000576420 ENST00000577079 ENST00000574722 ENST00000570638
    ENST00000574953 ENST00000573780 ENST00000575736 ENST00000575130 ENST00000575634
    ENST00000573588

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RPH3AL (see all 9):
    hsa-miR-892b hsa-miR-200a hsa-miR-520a-5p hsa-miR-141 hsa-miR-124 hsa-miR-525-5p hsa-miR-149 hsa-miR-3202
    SwitchGear 3'UTR luciferase reporter plasmidRPH3AL 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat RPH3AL

    Additional mRNA sequence: 

    AF129812.1 AK000469.1 AK125265.1 AK291950.1 BC005153.1 BC093776.1 BC113413.1 BC143311.1 

    11 DOTS entries:

    DT.95265080  DT.97767703  DT.95265077  DT.91930087  DT.102630  DT.100024581  DT.120970368  DT.92421235 
    DT.100024580  DT.75195646  DT.204898 

    Selected AceView cDNA sequences (see all 82):

    CK818910 CD722823 AW338854 BU197069 BM264290 BM126316 BX393787 BF058077 
    CK818909 BU071688 AI298597 AI027577 BQ185163 BQ690360 AF129812 BC005153 
    AK000469 BQ878642 AA933807 AI004159 AA583168 AW592891 BQ955243 AV708334 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPH3AL expression in normal human tissues (normalized intensities)      RPH3AL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATACTTC
    RPH3AL Expression
    About this image


    RPH3AL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
    RPH3AL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPH3AL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.651925

    UniProtKB/Swiss-Prot: RPH3L_HUMAN, Q9UNE2
    Tissue specificity: Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal
    muscle, kidney and liver. Also detected in epithelial cells

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPH3AL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RPH3AL gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rph3al1 , 5 rabphilin 3A-like (without C2 domains)1, 5 85.05(n)1
    85.77(a)1
      11 (45.92 cM)5
    3807141  NM_029548.31  NP_083824.11 
     758309995 
    chicken
    (Gallus gallus)
    Aves RPH3AL1 rabphilin 3A-like (without C2 domains) 70.86(n)
    65.03(a)
      772026  XM_004946702.1  XP_004946759.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPH3AL6
    rabphilin 3A-like (without C2 domains)
    59(a)
    1 ↔ 1
    GL343992.1(150-48652)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rph3al1 rabphilin 3A-like (without C2 domains) 64.79(n)
    64.08(a)
      496416  NM_001011007.1  NP_001011007.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018841181 rab effector Noc2-like 68.99(n)
    68.7(a)
      101884118  XM_005168625.1  XP_005168682.1 


    ENSEMBL Gene Tree for RPH3AL (if available)
    TreeFam Gene Tree for RPH3AL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPH3AL gene
    1 SIMAP similar gene for RPH3AL using alignment to 12 protein entries:     RPH3L_HUMAN (see all proteins):
    RPH3A

    RPH3AL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPH3AL (see all 5137)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs739716561,2
    C,F--61716(+) ACTTCC/TACCTT 8 -- ds50013Minor allele frequency- T:0.10WA CSA 122
    rs802923811,2
    C,F--61772(+) CAAAGC/GAAATG 8 -- ds50011Minor allele frequency- G:0.09WA 118
    rs1181758551,2
    C,F--61849(+) TTCCAG/TCTTCC 8 -- ds50011Minor allele frequency- T:0.02NA 120
    rs116506411,2
    C,F,H--61971(+) cagagG/Aaaaat 8 -- ds50015Minor allele frequency- A:0.00NS EA NA 418
    rs1488285901,2
    --62039(+) TTTTGC/TATACA 8 -- ds50010--------
    rs1452132161,2
    --62090(+) TACTTC/TTGTAT 8 -- ds50010--------
    rs1381537861,2
    C--62235(+) ATGGAC/TGCATC 8 -- ut310--------
    rs1924783581,2
    --62236(+) TGGACA/GCATCT 8 -- ut310--------
    rs1857928151,2
    --62328(+) ATAACA/GTGCCA 8 -- ut310--------
    rs612685491,2
    C,F--62444(+) AACCCG/AGGGTT 8 -- ut313Minor allele frequency- A:0.04WA CSA 122

    HapMap Linkage Disequilibrium report for RPH3AL (62180 - 236045 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RPH3AL (see all 153):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1621302CNV Deletion17803354
    esv2715216CNV Deletion23290073
    nsv820771CNV Deletion20802225
    esv2715220CNV Deletion23290073
    esv2183072CNV Deletion18987734
    esv2715242CNV Deletion23290073
    esv2715230CNV Deletion23290073
    esv2715227CNV Deletion23290073
    esv2715254CNV Deletion23290073
    esv2715261CNV Deletion23290073

    Human Gene Mutation Database (HGMD): RPH3AL
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPH3AL
    DNA2.0 Custom Variant and Variant Library Synthesis for RPH3AL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604881    OMIM disorders: --

    9 diseases for RPH3AL:    About MalaCards
    miller-dieker syndrome    lissencephaly    pancreatitis    medulloblastoma
    asthma    colorectal cancer    thyroiditis    adenocarcinoma
    prostatitis


    RPH3AL for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): RPH3AL
    Human Genome Epidemiology (HuGE) Navigator: RPH3AL (2 documents)

    Export disorders for RPH3AL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPH3AL gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with RPH3AL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus. (PubMed id 10395805)1, 2, 3 Smith J.S.... Raffel C. (Genomics 1999)
    2. Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells. (PubMed id 15003533)1, 2, 9 Manabe S.... Sasaki T. (Biochem. Biophys. Res. Commun. 2004)
    3. Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma. (PubMed id 17981610)1, 4, 9 Katkoori V.R....Manne U. (Front. Biosci. 2008)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Immunohistochemical expression of rabphilin-3A-like (Noc2) in normal and tumor tissues of human endocrine pancreas. (PubMed id 19212825)1, 9 Shanmugam C....Manne U. (amp 2009)
    8. Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. (PubMed id 12578829)1, 9 Fukuda M. (J. Biol. Chem. 2003)
    9. Mutations of rabphillin-3A-like gene in colorectal cancers. (PubMed id 12375017)1, 9 Goi T....Yamaguchi A. (Oncol. Rep. 2002)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9501 HGNC: 10296 AceView: RPH3AL Ensembl:ENSG00000181031 euGenes: HUgn9501
    ECgene: RPH3AL H-InvDB: RPH3AL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RPH3AL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RPH3AL gene:
    Search GeneIP for patents involving RPH3AL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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