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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPH3AL Gene

protein-coding   GIFtS: 55
GCID: GC17M000062

Rabphilin 3A-Like (Without C2 Domains)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rabphilin 3A-Like (Without C2 Domains)1 2
NOC22 3 5
No C2 Domains Protein2 3
Rab Effector Noc22
Rabphilin-3A-Like Protein3

External Ids:    HGNC: 102961   Entrez Gene: 95012   Ensembl: ENSG000001810317   OMIM: 6048815   UniProtKB: Q9UNE23   

Export aliases for RPH3AL gene to outside databases

Previous GC identifers: GC17M000112 GC17M000100


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPH3AL Gene:
The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both
endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a
tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
(provided by RefSeq, Jun 2010)

GeneCards Summary for RPH3AL Gene: 
RPH3AL (rabphilin 3A-like (without C2 domains)) is a protein-coding gene. Diseases associated with RPH3AL include miller-dieker syndrome, and lissencephaly. GO annotations related to this gene include cytoskeletal protein binding and LIM domain binding.

UniProtKB/Swiss-Prot: RPH3L_HUMAN, Q9UNE2
Function: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine
cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells

Gene Wiki entry for RPH3AL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_024972.8  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPH3AL gene promoter:
         SRF   SRF (504 AA)   p300   HSF1 (long)   AREB6   IRF-2   HSF1short   IRF-7A   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPH3AL promoter sequence
   Search SABiosciences Chromatin IP Primers for RPH3AL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPH3AL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

RPH3AL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPH3AL gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M000062:  view genomic region     (about GC identifiers)

Start:
62,180 bp from pter      End:
236,045 bp from pter
Size:
173,866 bases      Orientation:
minus strand

1 alternative location:
Chr17-,NW_003315952 62,180-220,466     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RPH3L_HUMAN, Q9UNE2 (See protein sequence)
Recommended Name: Rab effector Noc2  
Size: 315 amino acids; 34464 Da
Subunit: Recruited to dense-core vesicles through specific interaction with RAB27A in endocrine cells. Interacts
with RAB3A, RAB3B, RAB3C and RAB3D. Interacts with ZYX (By similarity)
Subcellular location: Cytoplasm. Cytoplasmic vesicle, secretory vesicle membrane. Note=Recruited to the vesicle
membrane in a GTP- and RAB3B-dependent manner in epithelial cells
Secondary accessions: D3DTG7 Q9BSB3
Alternative splicing: 2 isoforms:  Q9UNE2-1   Q9UNE2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RPH3AL: NX_Q9UNE2

Explore proteomics data for RPH3AL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UNE2

  • RPH3AL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPH3AL Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001177340.1  NP_001177341.1  NP_001177342.1  NP_008918.1  

    ENSEMBL proteins: 
     ENSP00000328977   ENSP00000319210   ENSP00000438224   ENSP00000460080   ENSP00000459795  
     ENSP00000459716   ENSP00000460580   ENSP00000459666   ENSP00000459992   ENSP00000459001  
     ENSP00000460171   ENSP00000461885   ENSP00000459975   ENSP00000458643  

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    Cloud-Clone Corp. Proteins for RPH3AL 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS9367993
    GO:0030141secretory granule ----
    GO:0030658transport vesicle membrane IEA--
    GO:0030667secretory granule membrane IEA--

    RPH3AL for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR003315 Rabphilin3A_effector_Zn-bd
     IPR017455 Znf_FYVE-rel
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD
     IPR010911 Rab-bd_domain

    Graphical View of Domain Structure for InterPro Entry Q9UNE2

    ProtoNet protein and cluster: Q9UNE2

    1 Blocks protein domain: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: RPH3L_HUMAN, Q9UNE2
    Domain: The N-terminus of the RabBD domain is necessary and sufficient for interaction with RAB27A (By similarity)
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 1 RabBD (Rab-binding) domain


    RPH3AL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPH3L_HUMAN, Q9UNE2
    Function: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine
    cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells

         Genatlas biochemistry entry for RPH3AL:
    rabphillin 3A-like,ortholog of rat Rph3al,involved in regulated endocrine exocytosis,but not in the oncogenesis of
    medulloblastoma or other carcinomas

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008092cytoskeletal protein binding TAS9367993
    GO:0008270zinc ion binding ----
    GO:0017137Rab GTPase binding IEA--
    GO:0030274LIM domain binding IEA--
         
    RPH3AL for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rph3al):
     digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism 

    RPH3AL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rph3altm1Sse for RPH3AL

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPH3AL About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    1 BioSystems Pathway for RPH3AL
        Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPH3AL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for RPH3AL (Q9UNE23 ENSP000003192104) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB27BO001943, ENSP000002620944I2D: score=3 STRING: ENSP00000262094
    RAB26Q9ULW53, ENSP000002101874I2D: score=1 STRING: ENSP00000210187
    ZYXQ159423, ENSP000003244224I2D: score=1 STRING: ENSP00000324422
    RAB27AP511593, ENSP000003377614I2D: score=4 STRING: ENSP00000337761
    RAB3AP203363, ENSP000002222564I2D: score=5 STRING: ENSP00000222256
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006887exocytosis IEA--
    GO:0017158regulation of calcium ion-dependent exocytosis IEA--
    GO:0042493response to drug IEA--
    GO:0042593glucose homeostasis IEA--

    RPH3AL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RPH3AL (RPH3L)

    1 HMDB Compound for RPH3AL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RPH3AL / RPH3L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPH3AL gene (4 alternative transcripts): 
    NM_001190411.1  NM_001190412.1  NM_001190413.1  NM_006987.3  

    Unigene Cluster for RPH3AL:

    Rabphilin 3A-like (without C2 domains)
    Hs.651925  [show with all ESTs]
    Unigene Representative Sequence: BC005153
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000331302(uc010vpy.2 uc002fre.2 uc021tmx.1) ENST00000323434(uc002frf.2 uc010cjl.2)
    ENST00000572965 ENST00000536489 ENST00000572075 ENST00000570893 ENST00000576001
    ENST00000570954 ENST00000576420 ENST00000577079 ENST00000574722 ENST00000570638
    ENST00000574953 ENST00000573780 ENST00000575736 ENST00000575130 ENST00000575634
    ENST00000573588
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    Additional mRNA sequence: 

    AF129812.1 AK000469.1 AK125265.1 AK291950.1 BC005153.1 BC093776.1 BC113413.1 BC143311.1 

    11 DOTS entries:

    DT.95265080  DT.97767703  DT.95265077  DT.91930087  DT.102630  DT.100024581  DT.120970368  DT.92421235 
    DT.100024580  DT.75195646  DT.204898 

    24/82 AceView cDNA sequences (see all 82):

    AI027577 BM126316 BU071688 CK818909 CK818910 AW338854 BX393787 CD722823 
    BU197069 BF058077 BM264290 AI298597 BQ016806 AF129812 BX089247 NM_006987 
    BF433309 BU844679 BG331746 AA933807 BU568991 AV708334 BM048250 BE673808 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPH3AL expression in normal human tissues (normalized intensities)      RPH3AL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATACTTC
    RPH3AL Expression
    About this image


    RPH3AL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   
     
     Nose (Sensory Organs)
             nasopharynx ; respiratory epithelial cells   
     
     Lower Urinary Tract (Urinary System)
             urinary bladder ; urothelial cells   

    See RPH3AL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPH3AL

    SOURCE GeneReport for Unigene cluster: Hs.651925

    UniProtKB/Swiss-Prot: RPH3L_HUMAN, Q9UNE2
    Tissue specificity: Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal
    muscle, kidney and liver. Also detected in epithelial cells

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPH3AL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RPH3AL gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rph3al1 , 5 rabphilin 3A-like (without C2 domains)1, 5 83.62(n)1
    83.28(a)1
      11 (45.92 cM)5
    3807141  NM_029548.31  NP_083824.11 
     758309995 
    chicken
    (Gallus gallus)
    Aves RPH3AL1 rabphilin 3A-like (without C2 domains) 71.1(n)
    65.38(a)
      772026  XM_001235227.1  XP_001235228.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPH3AL6
    Uncharacterized protein
    60(a)
    1 ↔ 1
    GL343992.1(150-48652)
    zebrafish
    (Danio rerio)
    Actinopterygii rph3al6
    rabphilin 3A-like (without C2 domains)
    68(a)
    1 ↔ 1
    5(62614804-62620397)


    ENSEMBL Gene Tree for RPH3AL (if available)
    TreeFam Gene Tree for RPH3AL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPH3AL gene
    1 SIMAP similar gene for RPH3AL using alignment to 12 protein entries:     RPH3L_HUMAN (see all proteins):
    RPH3A

    RPH3AL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5137 SNPs in RPH3AL are shown (see all 5137)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs739716561,2
    C,F--61716(+) ACTTCC/TACCTT 8 -- ds50013Minor allele frequency- T:0.10WA CSA 122
    rs802923811,2
    C,F--61772(+) CAAAGC/GAAATG 8 -- ds50011Minor allele frequency- G:0.09WA 118
    rs1181758551,2
    C,F--61849(+) TTCCAG/TCTTCC 8 -- ds50011Minor allele frequency- T:0.02NA 120
    rs116506411,2
    C,F,H--61971(+) cagagG/Aaaaat 8 -- ds50015Minor allele frequency- A:0.00NS EA NA 418
    rs1488285901,2
    --62039(+) TTTTGC/TATACA 8 -- ds50010--------
    rs1452132161,2
    --62090(+) TACTTC/TTGTAT 8 -- ds50010--------
    rs1381537861,2
    C--62235(+) ATGGAC/TGCATC 8 -- ut310--------
    rs1924783581,2
    --62236(+) TGGACA/GCATCT 8 -- ut310--------
    rs1857928151,2
    --62328(+) ATAACA/GTGCCA 8 -- ut310--------
    rs612685491,2
    C,F--62444(+) AACCCG/AGGGTT 8 -- ut313Minor allele frequency- A:0.04WA CSA 122

    HapMap Linkage Disequilibrium report for RPH3AL (62180 - 236045 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/153 variations for RPH3AL (see all 153):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1621302CNV Deletion17803354
    esv2715216CNV Deletion23290073
    nsv820771CNV Deletion20802225
    esv2715220CNV Deletion23290073
    esv2183072CNV Deletion18987734
    esv2715242CNV Deletion23290073
    esv2715230CNV Deletion23290073
    esv2715227CNV Deletion23290073
    esv2715254CNV Deletion23290073
    esv2715261CNV Deletion23290073


    Human Gene Mutation Database (HGMD): RPH3AL
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604881    OMIM disorders: --

    7 diseases for RPH3AL:    About MalaCards
    miller-dieker syndrome    lissencephaly    pancreatitis    medulloblastoma
    colorectal cancer    thyroiditis    adenocarcinoma


    RPH3AL for disorders           About GeneDecksing

    Genetic Association Database (GAD): RPH3AL
    Human Genome Epidemiology (HuGE) Navigator: RPH3AL (2 documents)

    Export disorders for RPH3AL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPH3AL gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with RPH3AL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus. (PubMed id 10395805)1, 2, 3 Smith J.S.... Raffel C. (1999)
    2. Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells. (PubMed id 15003533)1, 2, 9 Manabe S.... Sasaki T. (2004)
    3. Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma. (PubMed id 17981610)1, 4, 9 Katkoori V.R....Manne U. (2008)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Immunohistochemical expression of rabphilin-3A-like (Noc2) in normal and tumor tissues of human endocrine pancreas. (PubMed id 19212825)1, 9 Shanmugam C....Manne U. (2009)
    8. Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. (PubMed id 12578829)1, 9 Fukuda M. (2003)
    9. Mutations of rabphillin-3A-like gene in colorectal cancers. (PubMed id 12375017)1, 9 Goi T....Yamaguchi A. (2002)
    10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9501 HGNC: 10296 AceView: RPH3AL Ensembl:ENSG00000181031 euGenes: HUgn9501
    ECgene: RPH3AL H-InvDB: RPH3AL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPH3AL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPH3AL gene:
    Search GeneIP for patents involving RPH3AL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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