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Aliases for RPF2 Gene

Aliases for RPF2 Gene

  • Ribosome Production Factor 2 Homolog (S. Cerevisiae) 2 3
  • Ribosome Biogenesis Protein RPF2 Homolog 3 4
  • Brix Domain-Containing Protein 1 3 4
  • Brix Domain Containing 1 2 3
  • BXDC1 3 4
  • Ribosomal Processing Factor 2 Homolog (S. Cerevisiae) 2
  • Ribosomal Processing Factor 2 Homolog 3
  • Ribosome Production Factor 2 Homolog 3
  • Homolog Of Rpf2 3
  • BA397G5.4 3

External Ids for RPF2 Gene

Previous Symbols for RPF2 Gene

  • BXDC1

Summaries for RPF2 Gene

GeneCards Summary for RPF2 Gene

RPF2 (Ribosome Production Factor 2 Homolog (S. Cerevisiae)) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPF2 Gene

Genomics for RPF2 Gene

Genomic Location for RPF2 Gene

110,982,015 bp from pter
111,028,263 bp from pter
46,249 bases
Plus strand

Genomic View for RPF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPF2 Gene

No data available for Regulatory Elements for RPF2 Gene

Proteins for RPF2 Gene

  • Protein details for RPF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosome production factor 2 homolog
    Protein Accession:
    Secondary Accessions:
    • Q5VXN1
    • Q8N4A1

    Protein attributes for RPF2 Gene

    306 amino acids
    Molecular mass:
    35583 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPF2 Gene

Proteomics data for RPF2 Gene at MOPED

Post-translational modifications for RPF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPF2 Gene

No data available for DME Specific Peptides for RPF2 Gene

Domains for RPF2 Gene

Protein Domains for RPF2 Gene



  • Contains 1 Brix domain.:
    • Q9H7B2
  • Belongs to the RPF2 family.:
    • Q9H7B2
genes like me logo Genes that share domains with RPF2: view

No data available for Gene Families for RPF2 Gene

Function for RPF2 Gene

Gene Ontology (GO) - Molecular Function for RPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019843 rRNA binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPF2: view

Phenotypes for RPF2 Gene

genes like me logo Genes that share phenotypes with RPF2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RPF2 Gene

Localization for RPF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPF2 Gene

Nucleus, nucleolus. Note=Associated with the nucleolus in an RNA-dependent manner.

Subcellular locations from

Jensen Localization Image for RPF2 Gene COMPARTMENTS Subcellular localization image for RPF2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with RPF2: view

Pathways for RPF2 Gene

SuperPathways for RPF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
genes like me logo Genes that share ontologies with RPF2: view

No data available for Pathways by source for RPF2 Gene

Transcripts for RPF2 Gene

Unigene Clusters for RPF2 Gene

Ribosome production factor 2 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPF2 Gene

No ASD Table

Relevant External Links for RPF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPF2 Gene

mRNA expression in normal human tissues for RPF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPF2 Gene

SOURCE GeneReport for Unigene cluster for RPF2 Gene Hs.372265

genes like me logo Genes that share expressions with RPF2: view

Orthologs for RPF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPF2 36
  • 99.89 (n)
  • 100 (a)
RPF2 37
  • 100 (a)
(Bos Taurus)
Mammalia RPF2 36
  • 92.81 (n)
  • 96.08 (a)
RPF2 37
  • 96 (a)
(Canis familiaris)
Mammalia RPF2 36
  • 93.57 (n)
  • 95.75 (a)
RPF2 37
  • 96 (a)
(Mus musculus)
Mammalia Rpf2 36
  • 88.56 (n)
  • 92.16 (a)
Rpf2 16
Rpf2 37
  • 92 (a)
(Monodelphis domestica)
Mammalia RPF2 37
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia RPF2 37
  • 80 (a)
(Rattus norvegicus)
Mammalia Rpf2 36
  • 87.15 (n)
  • 92.48 (a)
(Gallus gallus)
Aves RPF2 36
  • 78.64 (n)
  • 88.14 (a)
RPF2 37
  • 86 (a)
(Anolis carolinensis)
Reptilia RPF2 37
  • 80 (a)
African clawed frog
(Xenopus laevis)
Amphibia bxdc1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rpf2 36
  • 74.07 (n)
  • 79.74 (a)
Str.551 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4223 36
(Danio rerio)
Actinopterygii -- 36
rpf2 36
  • 65.57 (n)
  • 71.71 (a)
rpf2 37
  • 71 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003048 36
  • 51.8 (n)
  • 49.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7993 36
  • 51.07 (n)
  • 47.47 (a)
CG7993 37
  • 44 (a)
(Caenorhabditis elegans)
Secernentea Y54E10A.10 36
  • 49.12 (n)
  • 43.46 (a)
Y54E10A.10 37
  • 41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR215C 36
  • 48.91 (n)
  • 45.36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPF2 36
  • 52.13 (n)
  • 48.23 (a)
RPF2 37
  • 40 (a)
RPF2 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07931g 36
  • 49.88 (n)
  • 44.33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G23620 36
  • 52.66 (n)
  • 45.08 (a)
(Oryza sativa)
Liliopsida Os01g0513800 36
  • 50.34 (n)
  • 43.79 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08595 36
  • 49.58 (n)
  • 45.91 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC926.08c 36
  • 51.73 (n)
  • 47.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1078 37
  • 59 (a)
Species with no ortholog for RPF2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPF2 Gene

Gene Tree for RPF2 (if available)
Gene Tree for RPF2 (if available)

Paralogs for RPF2 Gene Pseudogenes for RPF2 Gene

genes like me logo Genes that share paralogs with RPF2: view

No data available for Paralogs for RPF2 Gene

Variants for RPF2 Gene

Sequence variations from dbSNP and Humsavar for RPF2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs809102 -- 111,002,286(-) ttttt(A/T)ttttt intron-variant
rs1044387 -- 111,025,603(+) CACTA(C/T)TGTTT utr-variant-3-prime
rs1044388 -- 111,025,605(+) CTACT(A/G)TTTCA utr-variant-3-prime
rs1044389 -- 111,025,640(+) CAAGC(A/G)TCAAT utr-variant-3-prime
rs1292091 -- 111,010,148(+) tttta(A/G)acagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPF2 Gene

Variant ID Type Subtype PubMed ID
nsv886538 CNV Gain 21882294
nsv830773 CNV Loss 17160897
esv2627811 CNV Deletion 19546169

Relevant External Links for RPF2 Gene

HapMap Linkage Disequilibrium report

Disorders for RPF2 Gene

Relevant External Links for RPF2

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RPF2: view

No data available for UniProtKB/Swiss-Prot for RPF2 Gene

Publications for RPF2 Gene

  1. Proteomic and targeted analytical identification of BXDC1 and EBNA1BP2 as dynamic scaffold proteins in the nucleolus. (PMID: 19170763) Hirano Y. … Horigome T. (Genes Cells 2009) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Rpf2p, an evolutionarily conserved protein, interacts with ribosomal protein L11 and is essential for the processing of 27 SB Pre-rRNA to 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae. (PMID: 12048200) Morita D. … Mizuta K. (J. Biol. Chem. 2002) 2 3
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4

Products for RPF2 Gene

Sources for RPF2 Gene

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