RPF2 Gene
protein-coding GIFtS : 48
GCID: GC06 P111306
ribosome production factor 2 homolog (S. cerevisiae) (Previous name: brix domain containing 1 ) (Previous symbol: BXDC1 )
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Aliasesfor RPF2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ribosome Production Factor 2 Homolog (S. Cerevisiae) 1 2 Ribosome Biogenesis Protein RPF2 Homolog2 3 BXDC11 2 3 FLJ210871 BA397G5.41 Homolog Of Rpf22 Brix Domain Containing 11 2 Ribosomal Processing Factor 2 Homolog2 Brix Domain-Containing Protein 12 3 Ribosome Production Factor 2 Homolog2
Export aliases for RPF2 gene to outside databases Previous GC identifers: GC06P111410 GC06P108874
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Summariesfor RPF2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Viewsfor RPF2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_025741.15 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for RPF2 Other transcription factors Search SABiosciences Chromatin IP Primers for RPF2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RPF2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21 RPF2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P111306: view genomic region
(about GC identifiers )
Start:
111,303,218 bp from pter
End:
111,347,303 bp from pter
Size:
44,086 bases
Orientation:
plus strand
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Proteinsfor RPF2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RPF2_HUMAN, Q9H7B2 (See
protein sequence )Recommended Name: Ribosome production factor 2 homolog Size : 306 amino acids; 35583 Da
Subcellular location : Nucleus, nucleolus. Note=Associated with the nucleolus in an RNA-dependent manner
Secondary accessions : Q5VXN1 Q8N4A1Explore the universe of human proteins at neXtProt for RPF2: NX_Q9H7B2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9H7B2 RPF2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_115570.1 ENSEMBL proteins: ENSP00000357857 ENSP00000402338 ENSP00000414026 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
RPF2 for ontologies About GeneDecksing RPF2 Antibody Products: Assay Products for RPF2:
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Protein
Domains / Familiesfor RPF2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RPF2 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9H7B2 ProtoNet protein and cluster: Q9H7B2
1 Blocks protein family : IPB007109 Brix domain UniProtKB/Swiss-Prot: RPF2_HUMAN, Q9H7B2 Similarity : Belongs to the RPF2 familySimilarity : Contains 1 Brix domain
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Functionfor RPF2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPF2 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPF2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RPF2 (NM_032194 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPF2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPF2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPF2
4 GenomeRNAi human phenotypes for RPF2 :
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Pathways & Interactionsfor RPF2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPF2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/312 Interacting proteins for RPF2 (Q9H7B2 3 ENSP00000402338 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 312 )About this table
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Drugs & Compoundsfor RPF2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RPF2 Search CenterWatch for drugs/clinical trials and news about RPF2
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Transcriptsfor RPF2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RPF2 gene: NM_032194.1 Unigene Cluster for RPF2:
Ribosome production factor 2 homolog (S. cerevisiae) Hs.372265 [show with all ESTs ] Unigene Representative Sequence: AL833613 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000368864 ENST00000441448 (uc003pun.3 uc003puo.3 ) ENST00000425871 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPF2 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPF2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RPF2 (NM_032194 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPF2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPF2
Additional cDNA sequence: AK024740.1 AK056264.1 AK292165.1 AK301662.1 AL833613.1 BC005347.1 BC035314.1
8 DOTS entries : DT.413903 DT.97793674
DT.120805623 DT.95173586 DT.121368375 DT.91985118 DT.121368368 DT.97792817 24/205 AceView cDNA sequences (see all 205 ):
BM787019 BQ011419 BC035314 BM982648 BQ010984 AI885480 AA404386 AI638766 BG286825 AW819530 AI989527 BQ016301 AW294027 AA809843 BM838484 BM700470 BM796820 BU615400 BQ216082 AW089370 BX281051 CB148131 AI082003 C20819 GeneLoc Exon Structure
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Expression for RPF2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RPF2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATACTTTTGG
About this image RPF2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Ovary Primary Follicle Primary Oocyte Female Gametocytes, Germ Cells Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See RPF2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPF2 SOURCE GeneReport for Unigene cluster: Hs.372265 SABiosciences Custom PCR Arrays for RPF2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RPF2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat RPF2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RPF2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RPF2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPF2
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Orthologsfor RPF2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPF2 gene from 10/34 species (see all 34 ) About this table
ENSEMBL Gene Tree for RPF2 (if available)TreeFam Gene Tree for RPF2 (if available)
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Paralogsfor RPF2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RPF2 gene
RPF2 for paralogs About GeneDecksing 2 Pseudogenes.org Pseudogenes for RPF2 PGOHUM00000247649 PGOHUM00000246042
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Genomic Variantsfor RPF2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RPF2 (111303218 - 111347303 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for RPF2 1 CNV : 99664
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RPF2
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Disorders
/ Diseasesfor RPF2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section RPF2 for disorders About MalaCards
RPF2 for disorders About GeneDecksing Human Genome Epidemiology (HuGE) Navigator: RPF2 (1 document)Export disorders for RPF2 gene to outside databases
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Publicationsfor RPF2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RPF2 gene, integrated from 9 sources (see all 18 ): (articles sorted by number of sources associating them with RPF2) Utopia : connect your pdf to the dynamic world of online information
Proteomic and targeted analytical identification of BXDC1 and EBNA1BP2 as dynamic scaffold proteins in the nucleolus. (PubMed id 19170763) 1 , 2 Hirano Y....Horigome T. (2009) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Rpf2p, an evolutionarily conserved protein, interacts with ribosomal protein L11 and is essential for the processing of 27 SB Pre-rRNA to 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae. (PubMed id 12048200) 1 , 3 Morita D....Mizuta K. (2002) Functional proteomic analysis of human nucleolus. (PubMed id 12429849) 1 , 2 Scherl A.... Diaz J.-J. (2002) Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326) 1 Tsai Y.C....Cristea I.M. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590) 1 Emanuele M.J....Elledge S.J. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for RPF2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RPF2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RPF2 gene
(According to HUGE )
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Specialized Databases showing RPF2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for RPF2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for RPF2 gene: Search GeneIP for patents involving RPF2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RPF2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for RPF2 OriGene shRNA RFP for RPF2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for RPF2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RPF2 OriGene Protein Over-expression Lysate for RPF2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RPF2 OriGene 3'-UTR Clone for RPF2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPF2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPF2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RPF2 OriGene Custom Protein Services for RPF2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPF2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RPF2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RPF2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RPF2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RPF2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RPF2
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RPF2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPF2
ThermoFisher Antibodies for RPF2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPF2
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Aliases for RPF2
Databases for RPF2
Disorders / Diseases for RPF2
Domains / Families for RPF2
Drugs / Compounds for RPF2
Expression for RPF2
Function for RPF2
Genomic Views for RPF2
Intellectual Property for RPF2
Orthologs for RPF2
Paralogs for RPF2
Pathways / Interactions for RPF2
Products for RPF2
Proteins for RPF2
Publications for RPF2
Search Box for RPF2
Summaries for RPF2
Transcripts for RPF2
Variants for RPF2
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