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RPF1 Gene

protein-coding   GIFtS: 51
GCID: GC01P084945

Ribosome Production Factor 1 Homolog (S. Cerevisiae)

(Previous name: brix domain containing 5)
(Previous symbol: BXDC5)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosome Production Factor 1 Homolog (S. Cerevisiae)1 2     2310066N05Rik2
BXDC51 2 3     RNA Processing Factor 1 (RPF1)2
Brix Domain Containing 51 2     NMP2005
Ribosome Production Factor 11 2     PRP195
Brix Domain-Containing Protein 52 3     PRPF195
Ribosome Biogenesis Protein RPF12 3     PSO45
RNA Processing Factor 11     

External Ids:    HGNC: 303501   Entrez Gene: 801352   Ensembl: ENSG000001171337   OMIM: 6083305   UniProtKB: Q9H9Y23   

Export aliases for RPF1 gene to outside databases

Previous GC identifers: GC01M085593 GC01P084082 GC01P084233 GC01P084367 GC01P084656 GC01P084717 GC01P083055


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RPF1 Gene:
RPF1 (ribosome production factor 1 homolog (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include RNA binding and rRNA binding.

UniProtKB/Swiss-Prot: RPF1_HUMAN, Q9H9Y2
Function: May be required for ribosome biogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Search for regulatory transcription factor binding sites for RPF1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RPF1 promoter sequence
   Search Chromatin IP Primers for RPF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22.3

RPF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPF1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P084945:  view genomic region     (about GC identifiers)

Start:
84,944,920 bp from pter      End:
84,964,033 bp from pter
Size:
19,114 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RPF1_HUMAN, Q9H9Y2 (See protein sequence)
Recommended Name: Ribosome production factor 1  
Size: 349 amino acids; 40111 Da
Sequence caution: Sequence=CAH71915.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5VSK7 Q6AHX1 Q8WXZ8

Explore the universe of human proteins at neXtProt for RPF1: NX_Q9H9Y2

Explore proteomics data for RPF1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys182, Lys237
  • Modification sites at PhosphoSitePlus

  • See RPF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079341.2  
    ENSEMBL proteins: 
     ENSP00000359690   ENSP00000359688  

    RPF1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPF1

     
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    antibodies-online proteins for RPF1 (6 products) 

     
    antibodies-online peptides for RPF1

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    antibodies-online antibodies for RPF1 (3 products) 

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    Cloud-Clone Corp. ELISAs for RPF1
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    Search eBioscience for ELISAs for RPF1 
    antibodies-online kits for RPF1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007109 Brix
     IPR004154 Anticodon-bd

    Graphical View of Domain Structure for InterPro Entry Q9H9Y2

    ProtoNet protein and cluster: Q9H9Y2

    1 Blocks protein domain: IPB007109 Brix domain

    UniProtKB/Swiss-Prot: RPF1_HUMAN, Q9H9Y2
    Similarity: Contains 1 Brix domain


    Find genes that share domains with RPF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPF1_HUMAN, Q9H9Y2
    Function: May be required for ribosome biogenesis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA11864606
    GO:0019843rRNA binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RPF1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for RPF1:
     Decreased TP53 protein express  Increased S DNA content  S arrest  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RPF1

    miRNA
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    miRTarBase miRNAs that target RPF1:
    hsa-mir-296-3p (MIRT038402)

    Block miRNA regulation of human, mouse, rat RPF1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate RPF1:
    hsa-miR-338-5p hsa-miR-548p hsa-miR-545 hsa-miR-1227
    SwitchGear 3'UTR luciferase reporter plasmidRPF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RPF1
    Predesigned siRNA for gene silencing in human, mouse, rat RPF1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): RPF1 (NM_001003694)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPF1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RPF1_HUMAN, Q9H9Y2: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA12429849

    Find genes that share ontologies with RPF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPF1
    Interactions:

        Search GeneGlobe Interaction Network for RPF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPF1 (Q9H9Y23 ENSP000003596884) via UniProtKB, MINT, STRING, and/or I2D (see all 219)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PES1O005413, ENSP000003467254I2D: score=5 STRING: ENSP00000346725
    GNL3Q9BVP23, ENSP000003957724I2D: score=3 STRING: ENSP00000395772
    KIAA0020Q153973, ENSP000003809824I2D: score=3 STRING: ENSP00000380982
    WDR12Q9GZL73, ENSP000002610154I2D: score=3 STRING: ENSP00000261015
    DDX54Q8TDD13, ENSP000003238584I2D: score=2 STRING: ENSP00000323858
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--

    Find genes that share ontologies with RPF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPF1 gene: 
    NM_025065.6  

    Unigene Cluster for RPF1:

    Ribosome production factor 1 homolog (S. cerevisiae)
    Hs.481202  [show with all ESTs]
    Unigene Representative Sequence: CR627468
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370656 ENST00000370654(uc001djv.4)
    miRNA
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    Block miRNA regulation of human, mouse, rat RPF1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate RPF1:
    hsa-miR-338-5p hsa-miR-548p hsa-miR-545 hsa-miR-1227
    SwitchGear 3'UTR luciferase reporter plasmidRPF1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat RPF1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): RPF1 (NM_001003694)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RPF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPF1
      QuantiTect SYBR Green Assays in human, mouse, rat RPF1
      QuantiFast Probe-based Assays in human, mouse, rat RPF1

    Additional mRNA sequence: 

    AF322053.1 AK022537.1 AL359584.2 BC016051.1 CR627468.1 

    19 DOTS entries:

    DT.100786735  DT.453771  DT.449808  DT.91854010  DT.95297551  DT.101977736  DT.95372073  DT.87015452 
    DT.40133257  DT.454485  DT.95297552  DT.121427627  DT.121427635  DT.40223192  DT.40273745  DT.91718199 
    DT.91785949  DT.92443364  DT.95297515 

    Selected AceView cDNA sequences (see all 178):

    BQ438263 BM976302 CA314033 CR605940 BP340463 AA252735 AA626511 NM_025065 
    AL583573 CA312833 AF322053 BU173176 BQ002538 BC016051 AA652876 BF057004 
    AL359584 CA442861 CR593992 CR626665 AA778053 AI749899 BU171573 BM461521 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RPF1 Expression
    About this image


    RPF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    RPF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.481202
        Custom PCR Arrays for RPF1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPF1 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpf11 , 5 ribosome production factor 1 homolog (S. cerevisiae)1, 5 89.11(n)1
    95.13(a)1
      3 (71.57 cM)5
    702851  NM_027371.31  NP_081647.21 
     1465063485 
    chicken
    (Gallus gallus)
    Aves RPF11 ribosome production factor 1 homolog (S. cerevisiae) 78.62(n)
    86.48(a)
      424539  XM_422376.4  XP_422376.4 
    lizard
    (Anolis carolinensis)
    Reptilia RPF16
    ribosome production factor 1 homolog (S. cerevisia...
    81(a)
    1 ↔ 1
    GL343194.1(9606944-9614127)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041557.12   -- 77.1(n)    BC041557.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rpf11 ribosome production factor 1 homolog (S. cerevisiae) 71.55(n)
    77.71(a)
      415250  NM_001002160.2  NP_001002160.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67121 , 3 CG67121 50(a)3
    51.56(n)1
    49.13(a)1
      33C43
    346311  NM_058131.41  NP_477479.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F44G4.11 , 3 F44G4.11 57(a)3
    61.74(n)1
    57.98(a)1
      II(8994544-8996001)3
    1744341  NM_063517.51  NP_495918.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPF1(YHR088W)4
    RPF11
    Nucleolar protein involved in the assembly and export more4
    RPF11
    56.54(n)1
    52.74(a)1
      8(281495-282382)4
    8564881, 4  NP_011956.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MEE491 MEE49 58.82(n)
    52.22(a)
      828136  NM_116386.3  NP_567213.1 
    rice
    (Oryza sativa)
    Liliopsida Os.159402 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.09(n)    AK121945.1 


    ENSEMBL Gene Tree for RPF1 (if available)
    TreeFam Gene Tree for RPF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPF1 gene
    1 SIMAP similar gene for RPF1 using alignment to 1 protein entry:     RPF1_HUMAN:
    IMP4

    Find genes that share paralogs with RPF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPF1 (see all 476)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs740954161,2
    C,F--84943104(+) ACTTTC/TTTCAC 1 -- us2k16Minor allele frequency- T:0.20WA NA EA 364
    rs1905625421,2
    C--84943201(+) GGACTC/TCTCCA 1 -- us2k10--------
    rs765937091,2
    C,F--84943247(+) ATCTAC/TACTCA 1 -- us2k11Minor allele frequency- T:0.04EA 120
    rs1831668341,2
    --84943469(+) TTCACC/TTGATG 1 -- us2k10--------
    rs75354451,2
    C,F,H--84943573(+) ttccaG/Taggaa 1 -- us2k112Minor allele frequency- T:0.18NS EA NA WA 780
    rs1422264971,2
    --84943616(+) TGGTTC/TAGGCC 1 -- us2k10--------
    rs792306691,2
    C,F--84943656(+) CCTGCC/TCCTGC 1 -- us2k11Minor allele frequency- T:0.07NA 120
    rs1856747011,2
    --84943676(+) TCTCAA/GAAGAA 1 -- us2k10--------
    rs1913780031,2
    --84943749(+) CCCAGC/GCTGGA 1 -- us2k10--------
    rs1832902221,2
    --84943825(+) AGCCTC/TCTGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPF1 (84944920 - 84964033 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RPF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830437CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPF1
    DNA2.0 Custom Variant and Variant Library Synthesis for RPF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608330    OMIM disorders: --


    Find genes that share disorders with RPF1           About GenesLikeMe


    Export disorders for RPF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPF1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with RPF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The sigma(70)-like motif: a eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis. (PubMed id 11864606)1, 2, 3 Wehner K.A. and Baserga S.J. (Mol. Cell 2002)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80135 HGNC: 30350 AceView: RPF1 Ensembl:ENSG00000117133 euGenes: HUgn80135
    ECgene: RPF1 H-InvDB: RPF1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPF1 gene:
    Search GeneIP for patents involving RPF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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