RPF1 Gene
protein-coding GIFtS: 47
GCID: GC01P084945
|
|
ribosome production factor 1 homolog (S. cerevisiae)(Previous name: brix domain containing 5 ) (Previous symbol: BXDC5)
| |
Aliases for RPF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ribosome Production Factor 1 Homolog (S. Cerevisiae)1 2 | | 2310066N05Rik2 | | BXDC51 2 3 | | RP11-118B23.12 | | Brix Domain Containing 51 2 | | Ribosome Production Factor 12 | | Brix Domain-Containing Protein 52 3 | | RNA Processing Factor 1 (RPF1)2 | | Ribosome Biogenesis Protein RPF12 3 | | BBR1405 |
Export aliases for RPF1 gene to outside databasesPrevious GC identifers: GC01M085593 GC01P084082 GC01P084233 GC01P084367 GC01P084656 GC01P084717 GC01P083055 |
Summaries for RPF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RPF1_HUMAN, Q9H9Y2Function: May be required for ribosome biogenesis
|
Genomic Views for RPF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for RPF1 Other transcription factors
Search SABiosciences Chromatin IP Primers for RPF1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPF1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p22.3 Ensembl cytogenetic band: 1p22.3 HGNC cytogenetic band: 1p22.3RPF1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P084945: view genomic region
(about GC identifiers)
Start:
|
84,944,920 bp from pter |
End:
|
84,964,033 bp from pter |
Size:
|
19,114 bases |
Orientation:
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plus strand |
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Proteins for RPF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RPF1_HUMAN, Q9H9Y2 (See
protein sequence)Recommended Name: Ribosome production factor 1 Size: 349 amino acids; 40111 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=CAH71915.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5VSK7 Q6AHX1 Q8WXZ8Explore the universe of human proteins at neXtProt for RPF1: NX_Q9H9Y2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H9Y2 RPF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079341.2 ENSEMBL proteins: ENSP00000359690 ENSP00000359688 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
RPF1 for ontologies About GeneDecksing
RPF1 Antibody Products: Assay Products for RPF1: |
Protein
Domains / Families for RPF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPF1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H9Y2ProtoNet protein and cluster: Q9H9Y2 1 Blocks protein family: IPB007109 Brix domain
UniProtKB/Swiss-Prot: RPF1_HUMAN, Q9H9Y2Similarity: Contains 1 Brix domain |
Function for RPF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: RPF1_HUMAN, Q9H9Y2Function: May be required for ribosome biogenesis
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPF1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPF1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RPF1 (NM_001003694) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPF1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPF1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RPF1 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for RPF1:
|
Pathways & Interactions for RPF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/105 Interacting proteins for RPF1 (Q9H9Y23 ENSP000003596884) via UniProtKB, MINT, STRING, and/or I2D (see all 105)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006364 | rRNA processing |
IEA | -- |
RPF1 for ontologies About GeneDecksing
|
Drugs & Compounds for RPF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for RPF1 Search CenterWatch for drugs/clinical trials and news about RPF1 
|
Transcripts for RPF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for RPF1 gene: NM_025065.6 Unigene Cluster for RPF1: Ribosome production factor 1 homolog (S. cerevisiae) Hs.481202 [show with all ESTs]Unigene Representative Sequence: CR6274682 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370656 ENST00000370654(uc001djv.4)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPF1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPF1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RPF1 (NM_001003694) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPF1  |
Additional cDNA sequence: AF322053.1 AK022537.1 AL359584.2 BC016051.1 CR627468.1 10 DOTS entries: DT.100786735 DT.453771 DT.91854010 DT.101977736 DT.95372073 DT.87015452 DT.454485 DT.40223192 DT.40273745 DT.91785949 24/178 AceView cDNA sequences (see all 178): BF057004 CA442861 BM976302 CA312833 BU171573 AL359584 AL583573 CA438100 CA314033 CD370191 NM_025065 AI749899 BQ002804 AA626511 BQ438263 BM461521 AW291571 CB250696 AF322053 AA252735 CR593992 BQ002538 CR605940 AA501513 GeneLoc Exon Structure
|
Expression for RPF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPF1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See RPF1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPF1
SOURCE GeneReport for Unigene cluster: Hs.481202 SABiosciences Custom PCR Arrays for RPF1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPF1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPF1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPF1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPF1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPF1 |
Orthologs for RPF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPF1 gene from 10/37 species (see all 37) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Rpf11 , 5 |
ribosome production factor 1 homolog (S. cerevisiae)1, 5 |
89.11(n)1 95.13(a)1 |
  |
3 (71.57 cM)5 702851 NM_027371.31 NP_081647.21 1465063485 |
chicken (Gallus gallus) |
Aves |
RPF11 |
ribosome production factor 1 homolog (S. cerevisiae) |
78.3(n) 85.98(a) |
  |
424539 XM_422376.3 XP_422376.3 |
lizard (Anolis carolinensis) |
Reptilia |
RPF16 |
-- |
80(a) |
1 ↔ 1 |
GL343194.1(9606944-9614127) |
African clawed frog (Xenopus laevis) |
Amphibia |
BC041557.12 |
-- |
77.1(n) |
  |
BC041557.1 |
zebrafish (Danio rerio) |
Actinopterygii |
rpf11 |
ribosome production factor 1 homolog (S. cerevisiae) |
71.1(n) 76.78(a) |
  |
415250 NM_001002160.1 NP_001002160.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
CG67121 , 3 |
CG67121 |
50(a)3 50.25(n)1 45.99(a)1 |
  |
33C43 346311 NM_058131.41 NP_477479.11 |
worm (Caenorhabditis elegans) |
Secernentea |
F44G4.11 , 3 |
Protein F44G4.11 |
57(a)3 60.07(n)1 55.76(a)1 |
  |
II(8994544-8996001)3 1744341 NM_063517.41 NP_495918.11 |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes |
RPF1(YHR088W)4 RPF11 |
Nucleolar protein involved in the assembly and export more4 Rpf1p1 |
54.92(n)1 49.47(a)1 |
  |
8(281495-282382)4 8564881, 4 NP_011956.11, 4 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
MEE491 |
ribosomal RNA processing brix domain-containing protein |
58.7(n) 52.56(a) |
  |
828136 NM_116386.3 NP_567213.1 |
rice (Oryza sativa) |
Liliopsida |
Os.159402 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
73.09(n) |
  |
AK121945.1 |
ENSEMBL Gene Tree for RPF1 (if available) TreeFam Gene Tree for RPF1 (if available)  |
Paralogs for RPF1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for RPF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for RPF1 (84944920 - 84964033 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RPF1: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPF1 |
|
Disorders
/ Diseases for RPF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPF1 for disorders About GeneDecksing
OMIM gene information: 602410
OMIM disorders: --
1 disease for RPF1: About MalaCardsmalaria Export disorders for RPF1 gene to outside databases
|
Publications for RPF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPF1 gene, integrated from 9 sources (see all 12): (articles sorted by number of sources associating them with RPF1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The sigma(70)-like motif: a eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis. (PubMed id 11864606)1, 2, 3 Wehner K.A. and Baserga S.J. (2002)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for RPF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RPF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for RPF1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RPF1 gene: Search GeneIP for patents involving RPF1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for RPF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for RPF1 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPF1 | | OriGene Protein Over-expression Lysate for RPF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for RPF1 | | OriGene 3'-UTR Clone for RPF1 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPF1 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for RPF1 | | OriGene Custom Protein Services for RPF1 | | OriGene Custom Immunoassay Development | | |
| |  |
 |
| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPF1 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPF1 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPF1 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPF1 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPF1 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPF1 |
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 |  |  |  | |
| | | Search Tocris compounds for RPF1 |
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 | | RPF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPF1 |
|  |  |  | | | ThermoFisher Antibodies for RPF1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPF1 |
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