Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RPE Gene

protein-coding   GIFtS: 62
GCID: GC02P210867

Ribulose-5-Phosphate-3-Epimerase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ribulose-5-phosphate-3-epimerase3
ribulose-5-phosphate-3-epimerase1 2
EC 5.1.3.13 8
RPE2-12
Ribulose-Phosphate 3-Epimerase2

External Ids:    HGNC: 102931   Entrez Gene: 61202   Ensembl: ENSG000001977137   OMIM: 1804805   UniProtKB: Q96AT93   

Export aliases for RPE gene to outside databases

Previous GC identifers: GC02P209142 GC02P209591 GC02P210831 GC02P211069 GC02P210692 GC02P210575 GC02P202712


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RPE Gene:
RPE (ribulose-5-phosphate-3-epimerase) is a protein-coding gene. Diseases associated with RPE include multiple carboxylase deficiency, and proliferative vitreoretinopathy. GO annotations related to this gene include protein homodimerization activity and monosaccharide binding. An important paralog of this gene is RPEL1.

UniProtKB/Swiss-Prot: RPE_HUMAN, Q96AT9
Function: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate

Gene Wiki entry for RPE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPE gene promoter:
         Sp1   AP-1   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPE promoter sequence
   Search Chromatin IP Primers for RPE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32-q33.3   Ensembl cytogenetic band:  2q34   HGNC cytogenetic band: 2q32-q33.3

RPE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPE gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P210867:  view genomic region     (about GC identifiers)

Start:
210,867,289 bp from pter      End:
210,886,300 bp from pter
Size:
19,012 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RPE_HUMAN, Q96AT9 (See protein sequence)
Recommended Name: Ribulose-phosphate 3-epimerase  
Size: 228 amino acids; 24928 Da
Cofactor: Binds 1 divalent metal cation per subunit. Active with Fe(2+), and probably also with Mn(2+), Zn(2+) and
Co(2+)
Subunit: Homodimer
Sequence caution: Sequence=BAB71076.1; Type=Frameshift; Positions=69; Sequence=BAC04212.1; Type=Frameshift;
Positions=42;
4 PDB 3D structures from and Proteopedia for RPE:
3OVP (3D)        3OVQ (3D)        3OVR (3D)        3QC3 (3D)    
Secondary accessions: A8K4S0 O43767 Q53TV9 Q8N215 Q96N34 Q9BSB5
Alternative splicing: 3 isoforms:  Q96AT9-1   Q96AT9-2   Q96AT9-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for RPE: NX_Q96AT9

Explore proteomics data for RPE at MOPED

3 DME Specific Peptides for RPE (Q96AT9)
 MDGHFVPN  LVMTVEPG  IEVDGGVGP 


See RPE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (8 alternative transcripts): 
NP_001265211.1  NP_001265212.1  NP_001265214.1  NP_001265215.1  NP_001265217.1  NP_001265218.1  NP_008847.1  NP_954699.1  

ENSEMBL proteins: 
 ENSP00000352401   ENSP00000403808   ENSP00000386194   ENSP00000394455   ENSP00000401838  
 ENSP00000412245   ENSP00000397674   ENSP00000392279   ENSP00000416805   ENSP00000405695  
 ENSP00000400449   ENSP00000402061   ENSP00000411405   ENSP00000389411   ENSP00000411186  
 ENSP00000439206   ENSP00000346501  
Reactome Protein details: Q96AT9

RPE Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for RPE
OriGene Protein Over-expression Lysate for RPE
OriGene MassSpec for RPE
OriGene Custom Protein Services for RPE
GenScript Custom Purified and Recombinant Proteins Services for RPE
Novus Biologicals RPE Proteins
Novus Biologicals RPE Lysates
Sino Biological Recombinant Protein for RPE
Sino Biological Cell Lysate for RPE
ProSpec Recombinant Protein for RPE
Cloud-Clone Corp. Proteins for RPE

RPE Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for RPE
OriGene Custom Antibody Services for RPE
Novus Biologicals RPE Antibodies
Abcam antibodies for RPE
Cloud-Clone Corp. Antibodies for RPE
ThermoFisher Antibodies for RPE
LSBio Antibodies in human, mouse, rat for RPE

RPE Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for RPE
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for RPE
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for RPE
Cloud-Clone Corp. CLIAs for RPE


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
4 InterPro protein domains:
 IPR013785 Aldolase_TIM
 IPR000056 Ribul_P_3_epim-like
 IPR011060 RibuloseP-bd_barrel
 IPR026019 Ribul_P_3_epim

Graphical View of Domain Structure for InterPro Entry Q96AT9

ProtoNet protein and cluster: Q96AT9

1 Blocks protein domain: IPB000056 Ribulose-phosphate 3-epimerase

UniProtKB/Swiss-Prot: RPE_HUMAN, Q96AT9
Similarity: Belongs to the ribulose-phosphate 3-epimerase family


RPE for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RPE_HUMAN, Q96AT9
Function: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate
Catalytic activity: D-ribulose 5-phosphate = D-xylulose 5-phosphate

     Genatlas biochemistry entry for RPE:
ribulose-5-phosphate-3-epimerase

     Enzyme Number (IUBMB): EC 5.1.3.11 2

     Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004750ribulose-phosphate 3-epimerase activity IDA--
GO:0016857racemase and epimerase activity, acting on carbohydrates and derivatives ----
GO:0042802identical protein binding IPI16189514
GO:0042803protein homodimerization activity IPI--
     
RPE for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPE
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPE

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPE
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPE

miRNA
Products:
    
miRTarBase miRNAs that target RPE:
hsa-mir-142-3p (MIRT021632), hsa-mir-1260b (MIRT052778)

Block miRNA regulation of human, mouse, rat RPE using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate RPE (see all 21):
hsa-miR-411* hsa-miR-362-3p hsa-miR-379* hsa-miR-16-2* hsa-miR-373* hsa-miR-641 hsa-miR-1323 hsa-miR-548c-3p
SwitchGear 3'UTR luciferase reporter plasmidRPE 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for RPE
Predesigned siRNA for gene silencing in human, mouse, rat RPE

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for RPE

Clone
Products:
     
OriGene clones in human, mouse for RPE (see all 12)
OriGene ORF clones in mouse, rat for RPE
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): RPE (NM_199229)
Sino Biological Human cDNA Clone for RPE
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPE
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPE

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for RPE
Browse ESI BIO Cell Lines and PureStem Progenitors for RPE 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPE


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
chloroplast2
nucleus2
plasma membrane1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005829cytosol TAS--
GO:0043231intracellular membrane-bounded organelle ----

RPE for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for RPE About   (see all 6)                                                                                              See pathways by source

SuperPathContained pathways About
1Pentose phosphate pathway (KEGG)
pentose phosphate pathway (non-oxidative branch)0.00
pentose phosphate pathway0.00
Pentose phosphate pathway
2Metabolism
Metabolism0.38
Metabolic pathways0.38
3Pentose Phosphate Pathway (WikiPathways)
Pentose Phosphate Pathway
Pentose phosphate pathway (hexose monophosphate shunt)0.00
4Carbon metabolism
Carbon metabolism0.38
Biosynthesis of amino acids0.38
5Glucuronidation
Pentose and glucuronate interconversions0.61

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


3 BioSystems Pathways for RPE
    pentose phosphate pathway
Pentose Phosphate Pathway
pentose phosphate pathway (non-oxidative branch)


1 Reactome Pathway for RPE
    Pentose phosphate pathway (hexose monophosphate shunt)


5 Kegg Pathways  (Kegg details for RPE):
    Pentose phosphate pathway
Pentose and glucuronate interconversions
Metabolic pathways
Carbon metabolism
Biosynthesis of amino acids


RPE for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Array including RPE: 
          Glucose Metabolism in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for RPE

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for RPE (Q96AT91, 2, 3 ENSP000003524014) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
InteractantInteraction Details
GeneCardExternal ID(s)
RPEQ96AT91, 2EBI-372480,EBI-372480 MINT-67523
G6PDP114133, ENSP000003771924I2D: score=1 STRING: ENSP00000377192
MAT1AQ002663, ENSP000003612874I2D: score=1 STRING: ENSP00000361287
PGDP522093, ENSP000002707764I2D: score=1 STRING: ENSP00000270776
TALDO1P378373, ENSP000003212594I2D: score=1 STRING: ENSP00000321259
About this table

Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005975carbohydrate metabolic process TAS--
GO:0006098pentose-phosphate shunt TAS--
GO:0008152metabolic process ----
GO:0009052pentose-phosphate shunt, non-oxidative branch ----
GO:0044281small molecule metabolic process TAS--

RPE for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RPE

3 HMDB Compounds for RPE    About this table
CompoundSynonyms CAS #PubMed Ids
Angiotensin IIHypertensin (see all 11)11128-99-7--
D-Ribulose 5-phosphateD-Ribulose 5-phosphate (see all 5)4151-19-3--
Xylulose 5-phosphateD-xylulose-5-P (see all 9)4212-65-1--

5 Novoseek inferred chemical compound relationships for RPE gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
phycoerythrobilin 86.6 3 15532563 (1), 15720763 (1)
fluorochrome 72.4 2 8207263 (1), 8556955 (1)
fitc 62.6 6 8207263 (1), 7822758 (1), 8556955 (1), 15822070 (1)
streptavidin 48.2 1 9831388 (1)
oxygen 0 3 11200082 (2)



RPE for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for RPE gene (8 alternative transcripts): 
NM_001278282.1  NM_001278283.1  NM_001278285.1  NM_001278286.1  NM_001278288.1  NM_001278289.1  NM_006916.2  NM_199229.2  

Unigene Cluster for RPE:

Ribulose-5-phosphate-3-epimerase
Hs.282260  [show with all ESTs]
Unigene Representative Sequence: BC063135
17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000359429(uc002vdn.3 uc010zjf.2 uc002vdr.3) ENST00000436630
ENST00000408981 ENST00000454822 ENST00000429921(uc002vdo.3 uc002vdp.3 uc010fup.3 uc002vdq.3)
ENST00000453724 ENST00000438265 ENST00000429907 ENST00000441588 ENST00000445268
ENST00000452025 ENST00000438204 ENST00000438191 ENST00000411934 ENST00000435437
ENST00000540255 ENST00000354506
Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat RPE using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate RPE (see all 21):
hsa-miR-411* hsa-miR-362-3p hsa-miR-379* hsa-miR-16-2* hsa-miR-373* hsa-miR-641 hsa-miR-1323 hsa-miR-548c-3p
SwitchGear 3'UTR luciferase reporter plasmidRPE 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for RPE
Predesigned siRNA for gene silencing in human, mouse, rat RPE
Clone
Products:
     
OriGene clones in human, mouse for RPE (see all 12)
OriGene ORF clones in mouse, rat for RPE
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): RPE (NM_199229)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPE
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPE
Primer
Products:
    
OriGene qPCR primer pairs and template standards for RPE
OriGene qSTAR qPCR primer pairs in human, mouse for RPE
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPE
  QuantiTect SYBR Green Assays in human, mouse, rat RPE
  QuantiFast Probe-based Assays in human, mouse, rat RPE

Additional mRNA sequence: 

AJ224326.1 AK056028.1 AK093658.1 AK096199.1 AK291035.1 AK303184.1 AK308741.1 AL833120.1 
BC005148.2 BC016764.1 BC063135.1 BC072401.1 

19 DOTS entries:

DT.113342  DT.100790620  DT.100790621  DT.120956789  DT.97845556  DT.95196239  DT.92439317  DT.92439319 
DT.100026577  DT.120956881  DT.92439312  DT.99966292  DT.75118993  DT.75173146  DT.95196244  DT.120956778 
DT.120956788  DT.95196243  DT.92028674 

Selected AceView cDNA sequences (see all 234):

AW006055 AA512986 NM_006916 AA593101 BP372095 W80360 AI089406 BU170935 
AI222711 CD367556 BM987077 CK903257 AW276384 AL711113 CD675658 AJ224326 
CB158349 BF589604 BG612497 AI580477 BM974116 BU631053 CR625804 AI421487 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for RPE    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1:                                                
SP2:                                                
SP3:                                                
SP4:              -                                 


ECgene alternative splicing isoforms for RPE

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

RPE expression in normal human tissues (normalized intensities)      RPE embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATACGTCGC
RPE Expression
About this image


RPE expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Brain (Nervous System)
         Medulla Oblongata
RPE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RPE Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.282260
    Pathway & Disease-focused RT2 Profiler PCR Array including RPE: 
          Glucose Metabolism in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for RPE
OriGene qSTAR qPCR primer pairs in human, mouse for RPE
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPE
QuantiTect SYBR Green Assays in human, mouse, rat RPE
QuantiFast Probe-based Assays in human, mouse, rat RPE
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPE

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPE gene from Selected species (see all 23)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rpe1 , 5 ribulose-5-phosphate-3-epimerase1, 5 91.96(n)1
97.37(a)1
  1 (33.61 cM)5
666461  NM_025683.21  NP_079959.21 
 667008315 
chicken
(Gallus gallus)
Aves RPE1 ribulose-5-phosphate-3-epimerase 79.79(n)
92.5(a)
  770045  XM_004942454.1  XP_004942511.1 
lizard
(Anolis carolinensis)
Reptilia --
Ribulose-phosphate 3-epimerase
93(a)
1 → many
1(113346107-113354783)
tropical clawed frog
(Xenopus tropicalis)
Amphibia rpe1 ribulose-5-phosphate-3-epimerase 76.02(n)
89.04(a)
  100158597  NM_001128024.1  NP_001121496.1 
zebrafish
(Danio rerio)
Actinopterygii rpe1 ribulose-5-phosphate-3-epimerase 72.81(n)
82.46(a)
  334897  NM_001243424.1  NP_001230353.1 
fruit fly
(Drosophila melanogaster)
Insecta CG304991 , 3 CG304991 62(a)
(best of 2)3
60.49(n)1
62.5(a)1
  43E13
356921  NM_136454.31  NP_610298.21 
worm
(Caenorhabditis elegans)
Secernentea F08F8.71 , 3 F08F8.71 60(a)3
61.6(n)1
60.83(a)1
  III(7417703-7418886)3
1760431  NM_066219.51  NP_498620.11 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPE1(YJL121C)4
RPE11
D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction more4
RPE11
58.03(n)1
57.27(a)1
  10(191090-190374)4
8533221, 4  NP_012414.11, 4 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G632901 AT1G63290 57.59(n)
55.87(a)
  842635  NM_105008.3  NP_176518.1 
rice
(Oryza sativa)
Liliopsida Os.86652 Oryza sativa D-ribulose-5-phosphate 3-epimerase mRNA, more 77.19(n)    AF189365.1 


ENSEMBL Gene Tree for RPE (if available)
TreeFam Gene Tree for RPE (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for RPE gene
RPEL12  
9 SIMAP similar genes for RPE using alignment to 13 protein entries:     RPE_HUMAN (see all proteins):
RPEL1    ZNF564    AURA2    CTSS    NF2    SHANK2
FAM175A    UTY    SPATS2L

RPE for paralogs           About GeneDecksing


Selected Pseudogenes.org Pseudogenes for RPE (see all 6)
PGOHUM00000242788 PGOHUM00000244652 PGOHUM00000246560 PGOHUM00000240410 PGOHUM00000237967


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for RPE (see all 396)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1909338491,2
--210865391(+) CAGGGA/GGCGGC 2 -- us2k10--------
rs1840258071,2
--210865417(+) TGGGCA/GCGCAG 2 -- us2k10--------
rs1889083931,2
--210865419(+) GGCGCA/GCAGGA 2 -- us2k10--------
rs1180022111,2
C,F--210865472(+) GTCCCG/AAGCCC 2 -- us2k11Minor allele frequency- A:0.03EA 120
rs1168208461,2
C,F--210865484(+) GCCCCG/ATAGAG 2 -- us2k11Minor allele frequency- A:0.05WA 118
rs1389161871,2
--210865601(+) GGGCCA/GCAGAG 2 -- us2k10--------
rs21104041,2
C,A,H--210865666(+) ccgccC/Tgtgcc 2 -- us2k114Minor allele frequency- T:0.00NS NA WA CSA EA 498
rs1921774071,2
--210865712(+) AGCTCC/TGGCCT 2 -- us2k10--------
rs1841850261,2
--210865774(+) CAAGCA/GCGGCC 2 -- us2k10--------
rs1870529981,2
--210865804(+) AGAAGA/GCACCG 2 -- us2k10--------

HapMap Linkage Disequilibrium report for RPE (210867289 - 210886300 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for RPE: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RPE
DNA2.0 Custom Variant and Variant Library Synthesis for RPE

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 180480    OMIM disorders: --

6 diseases for RPE:    About MalaCards
multiple carboxylase deficiency    proliferative vitreoretinopathy    age related macular degeneration    pneumonia
tuberculosis    malaria


RPE for disorders           About GeneDecksing


Export disorders for RPE gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for RPE gene, integrated from 10 sources (see all 38):
(articles sorted by number of sources associating them with RPE)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703)1, 2, 9 Stanchi F.... Valle G. (Yeast 2001)
  2. Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE. (PubMed id 20923965)1, 2 Liang W.... Liu Z.J. (FASEB J. 2011)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
  6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
  7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
  10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 6120 HGNC: 10293 AceView: RPE Ensembl:ENSG00000197713 euGenes: HUgn6120
ECgene: RPE Kegg: 6120 H-InvDB: RPE

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for RPE Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for RPE gene:
Search GeneIP for patents involving RPE

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for RPE   OriGene RNAi products in human, mouse, rat for RPE  
 OriGene qPCR primer pairs and template standards for RPE   OriGene Protein Over-expression Lysate for RPE  
 OriGene MassSpec something-or-other for RPE   OriGene clones in human, mouse for RPE  
 OriGene qSTAR qPCR primer pairs in human, mouse for RPE   OriGene Purified Protein for RPE  
 OriGene ORF clones in mouse, rat for RPE   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for RPE   OriGene Custom Protein Services for RPE  

 
 
 Block miRNA regulation of human, mouse, rat RPE using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RPE
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPE Predesigned siRNA for gene silencing in human, mouse, rat RPE
 QuantiFast Probe-based Assays in human, mouse, rat RPE QuantiTect SYBR Green Assays in human, mouse, rat RPE
 PCR Arrays including human, mouse, rat RPE Search Chromatin IP Primers for RPE
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPE  Search GeneGlobe Interaction Network for RPE
 Regulatory tfbs in RPE promoter
 GenScript Custom Purified and Recombinant Proteins Services for RPE GenScript cDNA clones with any tag delivered in your preferred vector for RPE
 GenScript Custom Assay Services for RPE GenScript Custom overexpressing Cell Line Services for RPE
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for RPE
 Proteins for RPE
 Cell Lysates for RPE
 cDNA Clones for RPE
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 RPE antibodies
 RPE proteins
 RPE lysates
 Antibodies for RPE
 See all of Abcam's Antibodies, Kits and Proteins for RPE
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for RPE
 Proteins for RPE
 Antibodies for RPE
 ELISAs for RPE
 CLIAs for RPE



 Browse ESI BIO Cell Lines and PureStem Progenitors for RPE
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPE
 SwitchGear 3'UTR luciferase reporter plasmids for RPE
 SwitchGear Promoter luciferase reporter plasmids for RPE
 ThermoFisher Antibodies for RPE
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPE
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPE
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPE
 LSBio Antibodies in human, mouse, rat for RPE
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      RPE gene at Home site.
Version: 3.12.136 22 July 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4