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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPE Gene

protein-coding GIFtS: 63
GCID: GC02P210867

ribulose-5-phosphate-3-epimerase

Explore 10 diseases affiliated with
RPE via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribulose-5-Phosphate-3-Epimerase¹
Ribulose-5-Phosphate-3-Epimerase¹
EC 5.1.3.1³ ⁸
RPE2-1²
Ribulose-Phosphate 3-Epimerase²

External Ids:	HGNC: 10293¹	Entrez Gene: 6120²	Ensembl: ENSG00000197713⁷	OMIM: 180480⁵	UniProtKB: Q96AT9³

Export aliases for RPE gene to outside databases

Previous GC identifers: GC02P209142 GC02P209591 GC02P210831 GC02P211069 GC02P210692 GC02P210575 GC02P202712

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RPE_HUMAN, Q96AT9

Function: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate

Gene Wiki entry for RPE

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPE gene promoter:
Sp1 AP-1 ATF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPE promoter sequence

Search SABiosciences Chromatin IP Primers for RPE

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPE

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32-q33.3 Ensembl cytogenetic band: 2q34 HGNC cytogenetic band: 2q32-q33.3

RPE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPE gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P210867: view genomic region (about GC identifiers)

Start:	210,867,289 bp from pter	End:	210,886,300 bp from pter
Size:	19,012 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RPE_HUMAN, Q96AT9 (See protein sequence)

Recommended Name: Ribulose-phosphate 3-epimerase

Size: 228 amino acids; 24928 Da

Cofactor: Binds 1 divalent metal cation per subunit. Contains tightly bound Fe(2+) when produced in E.coli, but the

physiological cofactor may be Co(2+), Mn(2+) or Zn(2+)

Subunit: Homodimer

Sequence caution: Sequence=BAB71076.1; Type=Frameshift; Positions=69; Sequence=BAC04212.1; Type=Frameshift;

Positions=42;

4 PDB 3D structures from and Proteopedia for RPE:

3OVP (3D)

3OVQ (3D)

3OVR (3D)

3QC3 (3D)

Secondary accessions: A8K4S0 O43767 Q8N215 Q96N34 Q9BSB5

Alternative splicing: 2 isoforms: Q96AT9-1 Q96AT9-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RPE: NX_Q96AT9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96AT9

3 DME Specific Peptides for RPE (Q96AT9)

MDGHFVPN

LVMTVEPG

IEVDGGVGP

RPE Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_008847.1 NP_954699.1

ENSEMBL proteins:

ENSP00000352401 ENSP00000403808 ENSP00000386194 ENSP00000394455 ENSP00000401838

ENSP00000412245 ENSP00000397674 ENSP00000392279 ENSP00000416805 ENSP00000405695

ENSP00000400449 ENSP00000402061 ENSP00000411405 ENSP00000389411 ENSP00000411186

ENSP00000439206 ENSP00000346501

Reactome Protein details: Q96AT9
Human Recombinant Protein Products for RPE:

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	OriGene Purified Protein: RPE OriGene Protein Over-expression Lysate (see all 2): RPE OriGene Custom Protein Services for RPE
	GenScript Custom Purified and Recombinant Proteins Services for RPE
	Novus Biologicals RPE Proteins Novus Biologicals RPE Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for RPE
	Uscn Proteins for RPE

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0043231	intracellular membrane-bounded organelle	IEA	--

RPE for ontologies About GeneDecksing

RPE Antibody Products:

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	Novus Biologicals RPE Antibodies
	Abcam antibodies for RPE
	Uscn Antibodies for RPE
	Search ThermoFisher Antibodies for RPE

Assay Products for RPE:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RPE
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RPE

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPE for domains About GeneDecksing

4 InterPro domains/families:

IPR013785 Aldolase_TIM

IPR000056 Ribul_P_3_epim-like

IPR011060 RibuloseP-bd_barrel

IPR026019 Ribul_P_3_epim

Graphical View of Domain Structure for InterPro Entry Q96AT9

ProtoNet protein and cluster: Q96AT9

1 Blocks protein family: IPB000056 Ribulose-phosphate 3-epimerase

UniProtKB/Swiss-Prot: RPE_HUMAN, Q96AT9

Similarity: Belongs to the ribulose-phosphate 3-epimerase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RPE_HUMAN, Q96AT9

Function: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate

Catalytic activity: D-ribulose 5-phosphate = D-xylulose 5-phosphate

Genatlas biochemistry entry for RPE:

ribulose-5-phosphate-3-epimerase

Enzyme Number (IUBMB): EC 5.1.3.1¹ ²

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004750	ribulose-phosphate 3-epimerase activity	IDA	--
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	--	--
GO:0042802	identical protein binding	IPI	--
GO:0042803	protein homodimerization activity	IPI	--
GO:0046872	metal ion binding	IDA	--

RPE for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RPE

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RPE Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPE
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate RPE (see all 21):
		hsa-miR-411* hsa-miR-362-3p hsa-miR-379* hsa-miR-16-2* hsa-miR-373* hsa-miR-641 hsa-miR-1323 hsa-miR-548c-3p

		SwitchGear 3'UTR luciferase reporter plasmid: RPE 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPE (see all 7) OriGene shRNA RFP: RPE OriGene siRNA: RPE
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPE
		Sirion Biotech Custom design and validation of potent shRNA sequences against RPE

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for RPE
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPE (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPE (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): RPE (NM_199229)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPE
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPE

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RPE
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		Sirion Biotech Customized stable knockdown cell line services for RPE Sirion Biotech Customized inducible knockdown cell line services for RPE Sirion Biotech Customized stable overexpressing cell line services for RPE Sirion Biotech Customized inducible overexpressing cell line services for RPE

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPE

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Pentose phosphate pathway (hexose monophosphate shunt)

	Pentose phosphate pathway (hexose monophosphate shunt)	1.00			pentose phosphate pathway	0.67
	Pentose Phosphate Pathway	0.88			pentose phosphate pathway (non-oxidative branch)	0.33

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Pentose and glucuronate interconversions

Pentose and glucuronate interconversions

1.00

Pentose phosphate pathway

Pentose phosphate pathway

1.00

MPS IIIC - Sanfilippo syndrome C

Metabolism of carbohydrates

0.47

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for RPE

	pentose phosphate pathway
	Pentose Phosphate Pathway
	pentose phosphate pathway (non-oxidative branch)

3 Reactome Pathways for RPE

	Metabolism of carbohydrates
	Pentose phosphate pathway (hexose monophosphate shunt)
	Metabolism

3 Kegg Pathways (Kegg details for RPE):

	Pentose phosphate pathway
	Pentose and glucuronate interconversions
	Metabolic pathways

RPE for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RPE

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

5/48 Interacting proteins for RPE (Q96AT9^{1, 2, 3} ENSP00000352401⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 48)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPE	Q96AT9¹^,²	EBI-372480,EBI-372480 MINT-67523
G6PD	P11413³, ENSP00000377192⁴	I2D: score=1 STRING: ENSP00000377192
MAT1A	Q00266³, ENSP00000361287⁴	I2D: score=1 STRING: ENSP00000361287
MLST8	Q9BVC4³, ENSP00000371888⁴	I2D: score=1 STRING: ENSP00000371888
PGD	P52209³, ENSP00000270776⁴	I2D: score=1 STRING: ENSP00000270776

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006098	pentose-phosphate shunt	TAS	--
GO:0009052	pentose-phosphate shunt, non-oxidative branch	IEA	--
GO:0044281	small molecule metabolic process	TAS	--

RPE for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RPE for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RPE

3 HMDB Compounds for RPE About this table

Compound	Synonyms	CAS #	PubMed Ids
Angiotensin II	Hypertensin (see all 11)	11128-99-7	--
D-Ribulose 5-phosphate	D-Ribulose 5-phosphate (see all 5)	4151-19-3	--
Xylulose 5-phosphate	D-xylulose-5-P (see all 9)	4212-65-1	--

5 Novoseek chemical compound relationships for RPE gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phycoerythrobilin	86.6	3	15532563 (1), 15720763 (1)
fluorochrome	72.4	2	8207263 (1), 8556955 (1)
fitc	62.6	6	8207263 (1), 7822758 (1), 8556955 (1), 15822070 (1)
streptavidin	48.2	1	9831388 (1)
oxygen	0	3	11200082 (2)

Search CenterWatch for drugs/clinical trials and news about RPE

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RPE gene (2 alternative transcripts):

NM_006916.1 NM_199229.1

Unigene Cluster for RPE:

Ribulose-5-phosphate-3-epimerase

Hs.282260 [show with all ESTs]

Unigene Representative Sequence: BC063135

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000359429(uc002vdn.3 uc010zjf.2 uc002vdr.3) ENST00000436630

ENST00000408981 ENST00000454822 ENST00000429921(uc002vdo.3 uc002vdp.3 uc010fup.3 uc002vdq.3)

ENST00000453724 ENST00000438265 ENST00000429907 ENST00000441588 ENST00000445268

ENST00000452025 ENST00000438204 ENST00000438191 ENST00000411934 ENST00000435437

ENST00000540255 ENST00000354506

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RPE Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPE
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate RPE (see all 21):
		hsa-miR-411* hsa-miR-362-3p hsa-miR-379* hsa-miR-16-2* hsa-miR-373* hsa-miR-641 hsa-miR-1323 hsa-miR-548c-3p

		SwitchGear 3'UTR luciferase reporter plasmid: RPE 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPE (see all 7) OriGene shRNA RFP: RPE OriGene siRNA: RPE
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPE
		Sirion Biotech Custom design and validation of potent shRNA sequences against RPE

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPE (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPE (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): RPE (NM_199229)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPE

Additional cDNA sequence:

AJ224326.1 AK056028.1 AK093658.1 AK096199.1 AK291035.1 AK303184.1 AK308741.1 AL833120.1

BC005148.2 BC016764.1 BC063135.1 BC072401.1

19 DOTS entries:

DT.113342 DT.100790621 DT.100790620 DT.97845556 DT.120956789 DT.95196239 DT.92439317 DT.92439319

DT.100026577 DT.120956881 DT.92439312 DT.99966292 DT.75118993 DT.75173146 DT.95196244 DT.120956778

DT.120956788 DT.95196243 DT.92028674

24/234 AceView cDNA sequences (see all 234):

AA838419 AI810028 AL711113 BU631053 AI474051 AI089406 AI285834 BQ023390

NM_006916 AU123644 BC072401 AI631744 BM739681 AA593101 NM_199229 BM974116

CD367556 BU170935 AI421487 AW338492 AJ224326 AW276384 BM838963 BM987077

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for RPE About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6
SP1:
SP2:
SP3:
SP4:					-

ECgene alternative splicing isoforms for RPE

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATACGTCGC

About this image

RPE expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Ventral Foregut Endoderm

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RPE Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPE

SOURCE GeneReport for Unigene cluster: Hs.282260

SABiosciences Expression via Pathway-Focused PCR Array including RPE:

Glucose Metabolism in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPE Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RPE
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPE
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPE

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPE

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for RPE gene from 10/36 species (see all 36) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rpe^{1 , 5}	ribulose-5-phosphate-3-epimerase^{1, 5}	91.96(n)¹ 97.37(a)¹		1 (33.61 cM)⁵ 66646¹ NM_025683.2¹ NP_079959.2¹ 66700831⁵
chicken (Gallus gallus)	Aves	RPE¹	ribulose-5-phosphate-3-epimerase	79.79(n) 92.5(a)		770045 XM_001232387.2 XP_001232388.2
lizard (Anolis carolinensis)	Reptilia	RPE⁶	--	93(a)	1 ↔ 1	1(113346493-113354783)
zebrafish (Danio rerio)	Actinopterygii	rpe¹	ribulose-5-phosphate-3-epimerase	72.51(n) 82.46(a)		334897 NM_201312.1 NP_958469.1
fruit fly (Drosophila melanogaster)	Insecta	CG30499^{1 , 3}	CG30499¹	62(a) (best of 2)³ 61.43(n)¹ 63.81(a)¹		43E1³ 35692¹ NM_136454.2¹ NP_610298.2¹
worm (Caenorhabditis elegans)	Secernentea	F08F8.7^{1 , 3}	Protein F08F8.7¹	60(a)³ 61.86(n)¹ 61.4(a)¹		III(7417703-7418886)³ 176043¹ NM_066219.4¹ NP_498620.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPE1(YJL121C)⁴ RPE1¹	D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction more⁴ Rpe1p¹	58.03(n)¹ 57.27(a)¹		10(191090-190374)⁴ 853322^{1, 4} NP_012414.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G63290¹	putative D-ribulose-5-phosphate 3-epimerase	58.45(n) 57(a)		842635 NM_105008.3 NP_176518.1
rice (Oryza sativa)	Liliopsida	Os.8665²	Oryza sativa D-ribulose-5-phosphate 3-epimerase mRNA, more	77.19(n)		AF189365.1
E. coli (Escherichia coli)	Gamma proteobacteria	rpe⁶ alsE⁶ (see all 3)	allulose-6-phosphate 3-epimerase (see all 3)	38(a) 32(a) (see all 3)	possible ortholog many → 1 (see all 3)	Chromosome(3512404-3513081) Chromosome(4305806-4306501)

ENSEMBL Gene Tree for RPE (if available)
TreeFam Gene Tree for RPE (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RPE gene

8 SIMAP similar genes for RPE using alignment to 14 protein entries: RPE_HUMAN (see all proteins):

LOC729020 ZNF564 AURA2 NF2 SHANK2 FAM175A

UTY SPATS2L

RPE for paralogs About GeneDecksing

5/6 Pseudogenes.org Pseudogenes for RPE (see all 6)
PGOHUM00000242788 PGOHUM00000244652 PGOHUM00000246560 PGOHUM00000240410 PGOHUM00000237967

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190933849^1,2		--	210865391(+)	`CAGGGA/GGCGGC`	2	--	us2k¹		0	--	--	--	--
rs184025807^1,2		--	210865417(+)	`TGGGCA/GCGCAG`	2	--	us2k¹		0	--	--	--	--
rs188908393^1,2		--	210865419(+)	`GGCGCA/GCAGGA`	2	--	us2k¹		0	--	--	--	--
rs118002211^1,2	F	--	210865472(+)	`GTCCCG/AAGCCC`	2	--	us2k¹		1		EA	120
rs116820846^1,2	F	--	210865484(+)	`GCCCCG/ATAGAG`	2	--	us2k¹		1		WA	118
rs138916187^1,2		--	210865601(+)	`GGGCCA/GCAGAG`	2	--	us2k¹		0	--	--	--	--
rs2110404^1,2	C,A,H	--	210865666(+)	`CCGCCC/TGTGCC`	2	--	us2k¹		14		NS NA WA CSA EA	498
rs192177407^1,2		--	210865712(+)	`AGCTCC/TGGCCT`	2	--	us2k¹		0	--	--	--	--
rs184185026^1,2		--	210865774(+)	`CAAGCA/GCGGCC`	2	--	us2k¹		0	--	--	--	--
rs187052998^1,2		--	210865804(+)	`AGAAGA/GCACCG`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RPE (210867289 - 210886300 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RPE: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RPE for disorders           About GeneDecksing

OMIM gene information: 180480    OMIM disorders: --

10 diseases for RPE:    About MalaCards

vitreoretinopathy liver cancer pneumonia tuberculosis

malaria mycobacterium tuberculosis

1 disease from the University of Copenhagen DISEASES database for RPE:

Multiple carboxylase deficiency

Export disorders for RPE gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RPE gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with RPE)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703)^{1, 2, 9} Stanchi F.... Valle G. (2001)
Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE. (PubMed id 20923965)^{1, 2} Liang W.... Liu Z.J. (2011)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
Alu-SINE exonization: en route to protein-coding function. (PubMed id 15901843)¹ Krull M.... Schmitz J. (2005)
A protein interaction framework for human mRNA degradation. (PubMed id 15231747)¹ Lehner B. and Sanderson C.M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6120	HGNC: 10293	AceView: RPE	Ensembl:ENSG00000197713	euGenes: HUgn6120
ECgene: RPE	Kegg: 6120	H-InvDB: RPE

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RPE	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RPE gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RPE gene:
Search GeneIP for patents involving RPE

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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