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Aliases for RPE Gene

Aliases for RPE Gene

  • Ribulose-5-Phosphate-3-Epimerase 2 3 4
  • EC 5.1.3.1 4 64
  • Ribulose-Phosphate 3-Epimerase 3
  • RPE2-1 3

External Ids for RPE Gene

Summaries for RPE Gene

GeneCards Summary for RPE Gene

RPE (Ribulose-5-Phosphate-3-Epimerase) is a Protein Coding gene. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include protein homodimerization activity and monosaccharide binding. An important paralog of this gene is RPEL1.

UniProtKB/Swiss-Prot for RPE Gene

  • Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

Gene Wiki entry for RPE Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPE Gene

Genomics for RPE Gene

Genomic Location for RPE Gene

Start:
210,002,565 bp from pter
End:
210,024,601 bp from pter
Size:
22,037 bases
Orientation:
Plus strand

Genomic View for RPE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPE Gene

Regulatory Elements for RPE Gene

Transcription factor binding sites by QIAGEN in the RPE gene promoter:

Proteins for RPE Gene

  • Protein details for RPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AT9-RPE_HUMAN
    Recommended name:
    Ribulose-phosphate 3-epimerase
    Protein Accession:
    Q96AT9
    Secondary Accessions:
    • A8K4S0
    • B4E016
    • C9JPQ7
    • O43767
    • Q53TV9
    • Q8N215
    • Q96N34
    • Q9BSB5

    Protein attributes for RPE Gene

    Size:
    228 amino acids
    Molecular mass:
    24928 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Note=Binds 1 divalent metal cation per subunit. Active with Fe(2+), and probably also with Mn(2+), Zn(2+) and Co(2+).;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAB71076.1; Type=Frameshift; Positions=69; Evidence={ECO:0000305}; Sequence=BAC04212.1; Type=Frameshift; Positions=42; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPE Gene

    Alternative splice isoforms for RPE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPE Gene

Proteomics data for RPE Gene at MOPED

Selected DME Specific Peptides for RPE Gene

Post-translational modifications for RPE Gene

No Post-translational modifications

Domains for RPE Gene

UniProtKB/Swiss-Prot:

RPE_HUMAN
Family:
  • Belongs to the ribulose-phosphate 3-epimerase family.:
    • Q96AT9
genes like me logo Genes that share domains with RPE: view

No data available for Gene Families for RPE Gene

Function for RPE Gene

Molecular function for RPE Gene

GENATLAS Biochemistry: ribulose-5-phosphate-3-epimerase
UniProtKB/Swiss-Prot CatalyticActivity: D-ribulose 5-phosphate = D-xylulose 5-phosphate.
UniProtKB/Swiss-Prot Function: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

Enzyme Numbers (IUBMB) for RPE Gene

Gene Ontology (GO) - Molecular Function for RPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004750 ribulose-phosphate 3-epimerase activity IDA 20923965
GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives --
GO:0042802 identical protein binding IPI 16189514
GO:0042803 protein homodimerization activity IPI 20923965
genes like me logo Genes that share ontologies with RPE: view

miRNA for RPE Gene

miRTarBase miRNAs that target RPE

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPE Gene

Localization for RPE Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPE Gene COMPARTMENTS Subcellular localization image for RPE gene
Compartment Confidence
cytosol 4
chloroplast 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with RPE: view

Pathways for RPE Gene

genes like me logo Genes that share pathways with RPE: view

Gene Ontology (GO) - Biological Process for RPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006098 pentose-phosphate shunt TAS --
GO:0008152 metabolic process --
GO:0009052 pentose-phosphate shunt, non-oxidative branch IBA --
GO:0019323 pentose catabolic process IBA --
genes like me logo Genes that share ontologies with RPE: view

Compounds for RPE Gene

(3) HMDB Compounds for RPE Gene

Compound Synonyms Cas Number PubMed IDs
Angiotensin II
  • Hypertensin
11128-99-7
D-Ribulose 5-phosphate
  • D-Ribulose 5-phosphate
4151-19-3
Xylulose 5-phosphate
  • D-xylulose-5-P
4212-65-1

(5) Novoseek inferred chemical compound relationships for RPE Gene

Compound -log(P) Hits PubMed IDs
phycoerythrobilin 86.6 2
fluorochrome 72.4 2
fitc 62.6 4
streptavidin 48.2 1
oxygen 0 2
genes like me logo Genes that share compounds with RPE: view

Transcripts for RPE Gene

Unigene Clusters for RPE Gene

Ribulose-5-phosphate-3-epimerase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPE Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1:
SP2:
SP3:
SP4: -

Relevant External Links for RPE Gene

GeneLoc Exon Structure for
RPE
ECgene alternative splicing isoforms for
RPE

Expression for RPE Gene

mRNA expression in normal human tissues for RPE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPE Gene

SOURCE GeneReport for Unigene cluster for RPE Gene Hs.282260

genes like me logo Genes that share expressions with RPE: view

Orthologs for RPE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPE 36
  • 99.71 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RPE 36
  • 95.32 (n)
  • 98.25 (a)
RPE 37
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 98 (a)
OneToMany
RPE 36
  • 93.86 (n)
  • 97.81 (a)
mouse
(Mus musculus)
Mammalia Rpe 36
  • 91.96 (n)
  • 97.37 (a)
Rpe 16
Rpe 37
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rpe 36
  • 91.46 (n)
  • 97.99 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 91 (a)
OneToMany
RPE 36
  • 79.79 (n)
  • 92.5 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 93 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rpe 36
  • 76.02 (n)
  • 89.04 (a)
zebrafish
(Danio rerio)
Actinopterygii rpe 36
  • 72.81 (n)
  • 82.46 (a)
rpe 37
  • 82 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005080 36
  • 60.44 (n)
  • 61.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30499 36
  • 60.49 (n)
  • 62.5 (a)
CG30499 37
  • 61 (a)
OneToMany
boca 38
  • 62 (a)
CG30499 38
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea F08F8.7 36
  • 61.6 (n)
  • 60.83 (a)
F08F8.7 37
  • 58 (a)
OneToMany
F08F8.7 38
  • 60 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL208C 36
  • 53.79 (n)
  • 54.09 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPE1 36
  • 58.03 (n)
  • 57.27 (a)
RPE1 37
  • 53 (a)
OneToMany
RPE1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15071g 36
  • 58.33 (n)
  • 57.27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G63290 36
  • 57.59 (n)
  • 55.87 (a)
corn
(Zea mays)
Liliopsida Zm.14811 36
rice
(Oryza sativa)
Liliopsida Os.8665 36
Os09g0505700 36
  • 57.16 (n)
  • 53.39 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00519 36
  • 55.25 (n)
  • 53.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC31G5.05c 36
  • 55.1 (n)
  • 48.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 65 (a)
OneToMany
Species with no ortholog for RPE:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPE Gene

ENSEMBL:
Gene Tree for RPE (if available)
TreeFam:
Gene Tree for RPE (if available)

Paralogs for RPE Gene

Paralogs for RPE Gene

genes like me logo Genes that share paralogs with RPE: view

Variants for RPE Gene

Sequence variations from dbSNP and Humsavar for RPE Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs727700 -- 210,007,310(+) CTCCC(A/C)CACAC intron-variant
rs1014366 -- 210,005,715(+) ggcag(C/T)ctcac intron-variant
rs2075115 -- 210,017,089(+) TCCTC(C/G)CACCT intron-variant
rs2075116 -- 210,017,447(+) GAGTT(A/T)CTTAT intron-variant
rs2080188 -- 210,004,425(+) gcaca(A/G)agagg intron-variant

Relevant External Links for RPE Gene

HapMap Linkage Disequilibrium report
RPE

No data available for Structural Variations from Database of Genomic Variants (DGV) for RPE Gene

Disorders for RPE Gene

No disorders were found for RPE Gene.

No data available for UniProtKB/Swiss-Prot for RPE Gene

Publications for RPE Gene

  1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F. … Valle G. (Yeast 2001) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE. (PMID: 20923965) Liang W. … Liu Z.J. (FASEB J. 2011) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for RPE Gene

Sources for RPE Gene

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