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Aliases for RPE Gene

Aliases for RPE Gene

  • Ribulose-5-Phosphate-3-Epimerase 2 3 4 5
  • EC 4 63
  • RPE2-1 3

External Ids for RPE Gene

Previous GeneCards Identifiers for RPE Gene

  • GC02P209142
  • GC02P209591
  • GC02P210831
  • GC02P211069
  • GC02P210692
  • GC02P210575
  • GC02P202712
  • GC02P210867

Summaries for RPE Gene

GeneCards Summary for RPE Gene

RPE (Ribulose-5-Phosphate-3-Epimerase) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Pentose phosphate pathway. GO annotations related to this gene include protein homodimerization activity and racemase and epimerase activity, acting on carbohydrates and derivatives. An important paralog of this gene is RPEL1.

UniProtKB/Swiss-Prot for RPE Gene

  • Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

Gene Wiki entry for RPE Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPE Gene

Genomics for RPE Gene

Regulatory Elements for RPE Gene

Enhancers for RPE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPE on UCSC Golden Path with GeneCards custom track

Promoters for RPE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPE on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RPE gene promoter:

Genomic Location for RPE Gene

210,002,565 bp from pter
210,024,599 bp from pter
22,035 bases
Plus strand

Genomic View for RPE Gene

Genes around RPE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPE Gene

Proteins for RPE Gene

  • Protein details for RPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribulose-phosphate 3-epimerase
    Protein Accession:
    Secondary Accessions:
    • A8K4S0
    • B4E016
    • C9JPQ7
    • O43767
    • Q53TV9
    • Q8N215
    • Q96N34
    • Q9BSB5

    Protein attributes for RPE Gene

    228 amino acids
    Molecular mass:
    24928 Da
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    • Homodimer.
    • Sequence=BAB71076.1; Type=Frameshift; Positions=69; Evidence={ECO:0000305}; Sequence=BAC04212.1; Type=Frameshift; Positions=42; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPE Gene

    Alternative splice isoforms for RPE Gene


neXtProt entry for RPE Gene

Proteomics data for RPE Gene at MOPED

Selected DME Specific Peptides for RPE Gene

Post-translational modifications for RPE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for RPE

Domains & Families for RPE Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribulose-phosphate 3-epimerase family.
  • Belongs to the ribulose-phosphate 3-epimerase family.
genes like me logo Genes that share domains with RPE: view

No data available for Gene Families for RPE Gene

Function for RPE Gene

Molecular function for RPE Gene

GENATLAS Biochemistry:
UniProtKB/Swiss-Prot CatalyticActivity:
D-ribulose 5-phosphate = D-xylulose 5-phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

Enzyme Numbers (IUBMB) for RPE Gene

Gene Ontology (GO) - Molecular Function for RPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IPI 20923965
genes like me logo Genes that share ontologies with RPE: view
genes like me logo Genes that share phenotypes with RPE: view

Animal Model Products

miRNA for RPE Gene

miRTarBase miRNAs that target RPE

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPE Gene

Localization for RPE Gene

Subcellular locations from

Jensen Localization Image for RPE Gene COMPARTMENTS Subcellular localization image for RPE gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
chloroplast 2
plasma membrane 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RPE Gene

Pathways & Interactions for RPE Gene

genes like me logo Genes that share pathways with RPE: view

Gene Ontology (GO) - Biological Process for RPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA,IDA 20923965
GO:0044262 cellular carbohydrate metabolic process IBA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with RPE: view

No data available for SIGNOR curated interactions for RPE Gene

Drugs & Compounds for RPE Gene

(1) Drugs for RPE Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Angiotensin II Pharma Full agonist, Agonist Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 1126

(7) Additional Compounds for RPE Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Ribulose 5-phosphate
  • alpha-D-Ribose 5-phosphate
  • D-Ribulose 5-phosphate
  • Erythro-Pentulose 5-phosphate
  • Ribulose 5-phosphate
  • Ribulose phosphate
Xylulose 5-phosphate
  • D-Xylulose 5-phosphate
  • D-Xylulose 5-PO4
  • D-Xylulose-5-P
  • D-Xylulose-5-phosphate
  • Xu-5-P
genes like me logo Genes that share compounds with RPE: view

Transcripts for RPE Gene

Unigene Clusters for RPE Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPE Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP4: -

Relevant External Links for RPE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPE Gene

mRNA expression in normal human tissues for RPE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPE Gene

SOURCE GeneReport for Unigene cluster for RPE Gene Hs.282260

genes like me logo Genes that share expression patterns with RPE: view

Protein tissue co-expression partners for RPE Gene

- Elite partner

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPE Gene

Orthologs for RPE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPE Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPE 35
  • 95.32 (n)
  • 98.25 (a)
RPE 36
  • 98 (a)
(Canis familiaris)
Mammalia RPE 35
  • 93.86 (n)
  • 97.81 (a)
-- 36
  • 98 (a)
(Mus musculus)
Mammalia Rpe 35
  • 91.96 (n)
  • 97.37 (a)
Rpe 16
Rpe 36
  • 97 (a)
(Pan troglodytes)
Mammalia RPE 35
  • 99.71 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rpe 35
  • 91.46 (n)
  • 97.99 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 98 (a)
(Gallus gallus)
Aves RPE 35
  • 79.79 (n)
  • 92.5 (a)
-- 36
  • 91 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpe 35
  • 76.02 (n)
  • 89.04 (a)
(Danio rerio)
Actinopterygii rpe 35
  • 72.81 (n)
  • 82.46 (a)
rpe 36
  • 82 (a)
fruit fly
(Drosophila melanogaster)
Insecta boca 37
  • 62 (a)
CG30499 37
  • 62 (a)
CG30499 35
  • 60.49 (n)
  • 62.5 (a)
CG30499 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005080 35
  • 60.44 (n)
  • 61.21 (a)
(Caenorhabditis elegans)
Secernentea F08F8.7 37
  • 60 (a)
F08F8.7 35
  • 61.6 (n)
  • 60.83 (a)
F08F8.7 36
  • 58 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL208C 35
  • 53.79 (n)
  • 54.09 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15071g 35
  • 58.33 (n)
  • 57.27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPE1 35
  • 58.03 (n)
  • 57.27 (a)
RPE1 36
  • 53 (a)
RPE1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G63290 35
  • 57.59 (n)
  • 55.87 (a)
(Oryza sativa)
Liliopsida Os.8665 35
Os09g0505700 35
  • 57.16 (n)
  • 53.39 (a)
(Zea mays)
Liliopsida Zm.14811 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00519 35
  • 55.25 (n)
  • 53.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC31G5.05c 35
  • 55.1 (n)
  • 48.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
Species with no ortholog for RPE:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPE Gene

Gene Tree for RPE (if available)
Gene Tree for RPE (if available)

Paralogs for RPE Gene

Paralogs for RPE Gene

genes like me logo Genes that share paralogs with RPE: view

Variants for RPE Gene

Sequence variations from dbSNP and Humsavar for RPE Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs727700 -- 210,007,310(+) CTCCC(A/C)CACAC intron-variant
rs2723209 -- 210,008,296(+) tgttt(G/T)ttttt intron-variant
rs2723210 -- 210,009,160(+) CCCTC(A/G)GTGAA intron-variant
rs2723211 -- 210,015,768(+) AAATA(A/G)TGTTT intron-variant
rs2723213 -- 210,017,953(+) TTGGC(C/T)AGGCT intron-variant

Variation tolerance for RPE Gene

Residual Variation Intolerance Score: 30.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RPE Gene

Disorders for RPE Gene

Relevant External Links for RPE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPE Gene

Publications for RPE Gene

  1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F. … Valle G. (Yeast 2001) 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for RPE Gene

Sources for RPE Gene