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Aliases for RPAP3 Gene

Aliases for RPAP3 Gene

  • RNA Polymerase II Associated Protein 3 2 3

External Ids for RPAP3 Gene

Previous GeneCards Identifiers for RPAP3 Gene

  • GC12M046344
  • GC12M048057
  • GC12M045086

Summaries for RPAP3 Gene

Entrez Gene Summary for RPAP3 Gene

  • This gene encodes an RNA polymerase II-associated protein. The encoded protein may function in transcriptional regulation and may also regulate apoptosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

GeneCards Summary for RPAP3 Gene

RPAP3 (RNA Polymerase II Associated Protein 3) is a Protein Coding gene. An important paralog of this gene is TTC12.

UniProtKB/Swiss-Prot for RPAP3 Gene

  • Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPAP3 Gene

Genomics for RPAP3 Gene

Regulatory Elements for RPAP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPAP3 Gene

47,661,249 bp from pter
47,706,061 bp from pter
44,813 bases
Minus strand

Genomic View for RPAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPAP3 Gene

Proteins for RPAP3 Gene

  • Protein details for RPAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA polymerase II-associated protein 3
    Protein Accession:
    Secondary Accessions:
    • B4DRW9
    • Q6PHR5

    Protein attributes for RPAP3 Gene

    665 amino acids
    Molecular mass:
    75719 Da
    Quaternary structure:
    • Tightly associated with the RNA polymerase II complex.

    Three dimensional structures from OCA and Proteopedia for RPAP3 Gene

    Alternative splice isoforms for RPAP3 Gene


neXtProt entry for RPAP3 Gene

Proteomics data for RPAP3 Gene at MOPED

Post-translational modifications for RPAP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPAP3 Gene

No data available for DME Specific Peptides for RPAP3 Gene

Domains for RPAP3 Gene

Gene Families for RPAP3 Gene

  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for RPAP3 Gene

Suggested Antigen Peptide Sequences for RPAP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H6T3
  • Belongs to the RPAP3 family.
  • Contains 7 TPR repeats.
genes like me logo Genes that share domains with RPAP3: view

Function for RPAP3 Gene

Molecular function for RPAP3 Gene

UniProtKB/Swiss-Prot Function: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.

Gene Ontology (GO) - Molecular Function for RPAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18538670
genes like me logo Genes that share ontologies with RPAP3: view

Phenotypes for RPAP3 Gene

genes like me logo Genes that share phenotypes with RPAP3: view

Animal Model Products

CRISPR Products

miRNA for RPAP3 Gene

miRTarBase miRNAs that target RPAP3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPAP3 Gene

Localization for RPAP3 Gene

Subcellular locations from

Jensen Localization Image for RPAP3 Gene COMPARTMENTS Subcellular localization image for RPAP3 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RPAP3 Gene

Pathways for RPAP3 Gene

SuperPathways for RPAP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPAP3 Gene


No data available for Pathways by source for RPAP3 Gene

Transcripts for RPAP3 Gene

Unigene Clusters for RPAP3 Gene

RNA polymerase II associated protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPAP3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RPAP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPAP3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - - -

Relevant External Links for RPAP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPAP3 Gene

mRNA expression in normal human tissues for RPAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPAP3 Gene

SOURCE GeneReport for Unigene cluster for RPAP3 Gene Hs.437855

genes like me logo Genes that share expressions with RPAP3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPAP3 Gene

Orthologs for RPAP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPAP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPAP3 35
  • 99.35 (n)
  • 98.95 (a)
RPAP3 36
  • 99 (a)
(Bos Taurus)
Mammalia RPAP3 35
  • 90.51 (n)
  • 88.25 (a)
RPAP3 36
  • 88 (a)
(Canis familiaris)
Mammalia RPAP3 35
  • 91.7 (n)
  • 89.29 (a)
RPAP3 36
  • 89 (a)
(Mus musculus)
Mammalia Rpap3 35
  • 80.29 (n)
  • 79.64 (a)
Rpap3 16
Rpap3 36
  • 80 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
-- 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia RPAP3 36
  • 55 (a)
(Rattus norvegicus)
Mammalia Rpap3 35
  • 80.75 (n)
  • 78.57 (a)
(Gallus gallus)
Aves RPAP3 35
  • 71.98 (n)
  • 65.85 (a)
RPAP3 36
  • 65 (a)
(Anolis carolinensis)
Reptilia RPAP3 36
  • 58 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4828 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rpap3 35
  • 63.07 (n)
  • 58.8 (a)
Str.10319 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9134 35
(Danio rerio)
Actinopterygii rpap3 35
  • 55.14 (n)
  • 51.19 (a)
rpap3 36
  • 53 (a)
RPAP3 (2 of 2) 36
  • 44 (a)
zgc56178 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005014 35
  • 42.28 (n)
  • 28.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta spag 35
  • 43.68 (n)
  • 32.63 (a)
spag 36
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 36
  • 20 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G56440 35
  • 46.65 (n)
  • 35.44 (a)
(Oryza sativa)
Liliopsida Os05g0129900 35
  • 48.58 (n)
  • 37.58 (a)
Species with no ortholog for RPAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPAP3 Gene

Gene Tree for RPAP3 (if available)
Gene Tree for RPAP3 (if available)

Paralogs for RPAP3 Gene

Paralogs for RPAP3 Gene

genes like me logo Genes that share paralogs with RPAP3: view

Variants for RPAP3 Gene

Sequence variations from dbSNP and Humsavar for RPAP3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2025 -- 47,662,382(-) TTCAG(A/G)TTGTG utr-variant-3-prime
rs948394 -- 47,661,449(-) tgggt(A/G)taaGT downstream-variant-500B
rs1046438 -- 47,662,776(-) TTTGT(A/G)AACTT utr-variant-3-prime
rs1233042 -- 47,661,922(-) GTTTG(A/T)TATTT downstream-variant-500B
rs1233044 -- 47,676,926(-) tgtct(C/T)tgcca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPAP3 Gene

Variant ID Type Subtype PubMed ID
esv2751101 CNV Gain 17911159
nsv899058 CNV Gain 21882294
nsv695 CNV Loss 18451855
nsv518487 CNV Loss 19592680
nsv517899 CNV Gain 19592680

Relevant External Links for RPAP3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPAP3 Gene

Disorders for RPAP3 Gene

(1) University of Copenhagen DISEASES for RPAP3 Gene

genes like me logo Genes that share disorders with RPAP3: view

No data available for UniProtKB/Swiss-Prot for RPAP3 Gene

Publications for RPAP3 Gene

  1. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 2 3 4
  2. Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains. (PMID: 18538670) Itsuki Y. … Kamisaki Y. (FEBS Lett. 2008) 3
  3. RPAP3 interacts with Reptin to regulate UV-induced phosphorylation of H2AX and DNA damage. (PMID: 19180575) Ni L. … Kamisaki Y. (J. Cell. Biochem. 2009) 3
  4. High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes. (PMID: 19450687) Cloutier P. … Coulombe B. (Methods 2009) 3
  5. System-wide changes to SUMO modifications in response to heat shock. (PMID: 19471022) Golebiowski F. … Hay R.T. (Sci Signal 2009) 3

Products for RPAP3 Gene

Sources for RPAP3 Gene

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