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Aliases for RPAP3 Gene

Aliases for RPAP3 Gene

  • RNA Polymerase II Associated Protein 3 2 3 5

External Ids for RPAP3 Gene

Previous GeneCards Identifiers for RPAP3 Gene

  • GC12M046344
  • GC12M048057
  • GC12M045086

Summaries for RPAP3 Gene

Entrez Gene Summary for RPAP3 Gene

  • This gene encodes an RNA polymerase II-associated protein. The encoded protein may function in transcriptional regulation and may also regulate apoptosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

GeneCards Summary for RPAP3 Gene

RPAP3 (RNA Polymerase II Associated Protein 3) is a Protein Coding gene. An important paralog of this gene is SPAG1.

UniProtKB/Swiss-Prot for RPAP3 Gene

  • Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPAP3 Gene

Genomics for RPAP3 Gene

Regulatory Elements for RPAP3 Gene

Enhancers for RPAP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPAP3 on UCSC Golden Path with GeneCards custom track

Promoters for RPAP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPAP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPAP3 Gene

47,661,249 bp from pter
47,706,061 bp from pter
44,813 bases
Minus strand

Genomic View for RPAP3 Gene

Genes around RPAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPAP3 Gene

Proteins for RPAP3 Gene

  • Protein details for RPAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA polymerase II-associated protein 3
    Protein Accession:
    Secondary Accessions:
    • B4DRW9
    • Q6PHR5

    Protein attributes for RPAP3 Gene

    665 amino acids
    Molecular mass:
    75719 Da
    Quaternary structure:
    • Tightly associated with the RNA polymerase II complex (PubMed:17643375). Component of the R2TP complex composed at least of PIHD1, RUVBL1, RUVBL2 and RPAP3 (PubMed:20864032). Interacts with PIH1D1 (PubMed:21078300).

    Three dimensional structures from OCA and Proteopedia for RPAP3 Gene

    Alternative splice isoforms for RPAP3 Gene


neXtProt entry for RPAP3 Gene

Proteomics data for RPAP3 Gene at MOPED

Post-translational modifications for RPAP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPAP3 Gene

No data available for DME Specific Peptides for RPAP3 Gene

Domains & Families for RPAP3 Gene

Gene Families for RPAP3 Gene

Protein Domains for RPAP3 Gene

Suggested Antigen Peptide Sequences for RPAP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RPAP3 family.
  • Contains 7 TPR repeats.
  • Belongs to the RPAP3 family.
  • Contains 7 TPR repeats.
genes like me logo Genes that share domains with RPAP3: view

Function for RPAP3 Gene

Molecular function for RPAP3 Gene

UniProtKB/Swiss-Prot Function:
Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.
genes like me logo Genes that share phenotypes with RPAP3: view

Animal Model Products

CRISPR Products

miRNA for RPAP3 Gene

miRTarBase miRNAs that target RPAP3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPAP3 Gene

Localization for RPAP3 Gene

Subcellular locations from

Jensen Localization Image for RPAP3 Gene COMPARTMENTS Subcellular localization image for RPAP3 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RPAP3 Gene

Pathways & Interactions for RPAP3 Gene

SuperPathways for RPAP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPAP3 Gene


No data available for Pathways by source and SIGNOR curated interactions for RPAP3 Gene

Drugs & Compounds for RPAP3 Gene

No Compound Related Data Available

Transcripts for RPAP3 Gene

Unigene Clusters for RPAP3 Gene

RNA polymerase II associated protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPAP3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - - -

Relevant External Links for RPAP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPAP3 Gene

mRNA expression in normal human tissues for RPAP3 Gene

Protein differential expression in normal tissues from HIPED for RPAP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.6), Lymph node (13.3), and Breast (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPAP3 Gene

SOURCE GeneReport for Unigene cluster for RPAP3 Gene Hs.437855

genes like me logo Genes that share expression patterns with RPAP3: view

Protein tissue co-expression partners for RPAP3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPAP3 Gene

Orthologs for RPAP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPAP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPAP3 35
  • 90.51 (n)
  • 88.25 (a)
RPAP3 36
  • 88 (a)
(Canis familiaris)
Mammalia RPAP3 35
  • 91.7 (n)
  • 89.29 (a)
RPAP3 36
  • 89 (a)
(Mus musculus)
Mammalia Rpap3 35
  • 80.29 (n)
  • 79.64 (a)
Rpap3 16
Rpap3 36
  • 80 (a)
(Pan troglodytes)
Mammalia RPAP3 35
  • 99.35 (n)
  • 98.95 (a)
RPAP3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rpap3 35
  • 80.75 (n)
  • 78.57 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
-- 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia RPAP3 36
  • 55 (a)
(Gallus gallus)
Aves RPAP3 35
  • 71.98 (n)
  • 65.85 (a)
RPAP3 36
  • 65 (a)
(Anolis carolinensis)
Reptilia RPAP3 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpap3 35
  • 63.07 (n)
  • 58.8 (a)
Str.10319 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4828 35
(Danio rerio)
Actinopterygii rpap3 35
  • 55.14 (n)
  • 51.19 (a)
zgc56178 35
rpap3 36
  • 53 (a)
RPAP3 (2 of 2) 36
  • 44 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9134 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005014 35
  • 42.28 (n)
  • 28.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta spag 35
  • 43.68 (n)
  • 32.63 (a)
spag 36
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 36
  • 20 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G56440 35
  • 46.65 (n)
  • 35.44 (a)
(Oryza sativa)
Liliopsida Os05g0129900 35
  • 48.58 (n)
  • 37.58 (a)
Species with no ortholog for RPAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPAP3 Gene

Gene Tree for RPAP3 (if available)
Gene Tree for RPAP3 (if available)

Paralogs for RPAP3 Gene

Paralogs for RPAP3 Gene

genes like me logo Genes that share paralogs with RPAP3: view

Variants for RPAP3 Gene

Sequence variations from dbSNP and Humsavar for RPAP3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11168196 - 47,668,939(+) CATAT(A/C)TGGAG reference, missense
rs2057730 -- 47,702,947(-) GTATC(G/T)TGGCC intron-variant
rs2025 -- 47,662,382(-) TTCAG(A/G)TTGTG utr-variant-3-prime
rs7136422 -- 47,687,756(+) TAATT(C/T)CCAAT intron-variant
rs7136561 -- 47,687,854(+) TTGTA(C/T)GTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPAP3 Gene

Variant ID Type Subtype PubMed ID
esv2751101 CNV Gain 17911159
nsv899058 CNV Gain 21882294
nsv695 CNV Loss 18451855
nsv518487 CNV Loss 19592680
nsv517899 CNV Gain 19592680

Variation tolerance for RPAP3 Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPAP3 Gene

Disorders for RPAP3 Gene

Relevant External Links for RPAP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPAP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPAP3 Gene

Publications for RPAP3 Gene

  1. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for RPAP3 Gene

Sources for RPAP3 Gene