RPAP1 Gene
protein-coding GIFtS : 47
GCID: GC15 M041809
RNA polymerase II associated protein 1
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Aliasesfor RPAP1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases RNA Polymerase II Associated Protein 1 1 2 KIAA14031 3 5 DKFZP727M1111 FLJ127321 MGC8581 RNA Polymerase II-Associated Protein 12
Export aliases for RPAP1 gene to outside databases Previous GC identifers: GC15M039526 GC15M039596 GC15M018657
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Summariesfor RPAP1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for RPAP1 : This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. (provided by RefSeq, Jul 2012) UniProtKB/Swiss-Prot: RPAP1_HUMAN, Q9BWH6 Function : Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that itis required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3
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Genomic Viewsfor RPAP1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010194.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RPAP1 gene promoter: AML1a Other transcription factors Search SABiosciences Chromatin IP Primers for RPAP1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RPAP1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q15.1 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q14 RPAP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15M041809: view genomic region
(about GC identifiers )
Start:
41,809,374 bp from pter
End:
41,836,467 bp from pter
Size:
27,094 bases
Orientation:
minus strand
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Proteinsfor RPAP1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RPAP1_HUMAN, Q9BWH6 (See
protein sequence )Recommended Name: RNA polymerase II-associated protein 1 Size : 1393 amino acids; 152755 Da
Subunit : Part of a RNA polymerase II complex that contains POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G,POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, RPAP1, FCP1 plus the general transcription factors TFIIB and TFIIF
Subcellular location : Nucleus (By similarity)
Sequence caution : Sequence=BAA92641.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions : Q9H9I2 Q9NSQ5 Q9P2E4 Q9UFS7Alternative splicing : 3 isoforms : Q9BWH6-1 Q9BWH6-2 Q9BWH6-3 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for RPAP1: NX_Q9BWH6 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9BWH6 RPAP1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_056355.2 ENSEMBL proteins: ENSP00000456207 ENSP00000306123 ENSP00000455363 ENSP00000454508 ENSP00000457203 ENSP00000455381 ENSP00000455527 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
RPAP1 for ontologies About GeneDecksing RPAP1 Antibody Products: Assay Products for RPAP1:
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Protein
Domains / Familiesfor RPAP1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RPAP1 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9BWH6 ProtoNet protein and cluster: Q9BWH6
UniProtKB/Swiss-Prot: RPAP1_HUMAN, Q9BWH6 Similarity : Belongs to the RPAP1 family
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Functionfor RPAP1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: RPAP1_HUMAN, Q9BWH6 Function : Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that itis required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPAP1 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPAP1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RPAP1 (NM_002337 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPAP1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPAP1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPAP1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
IEA -- GO:0003899 DNA-directed RNA polymerase activity
IEA --
RPAP1 for ontologies About GeneDecksing
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Pathways & Interactionsfor RPAP1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPAP1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/45 Interacting proteins for RPAP1 (Q9BWH6 3 ENSP00000306123 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 45 )About this table
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Drugs & Compoundsfor RPAP1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RPAP1 Search CenterWatch for drugs/clinical trials and news about RPAP1
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Transcriptsfor RPAP1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RPAP1 gene: NM_015540.2 Unigene Cluster for RPAP1:
RNA polymerase II associated protein 1 Hs.371045 [show with all ESTs ] Unigene Representative Sequence: NM_015540 13 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000565167 ENST00000561603 ENST00000304330 (uc001zod.3 ) ENST00000562303 ENST00000568658 ENST00000564934 ENST00000565035 ENST00000561631 ENST00000568413 ENST00000563293 ENST00000567866 ENST00000566863 ENST00000569829 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPAP1 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPAP1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RPAP1 (NM_002337 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPAP1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPAP1
Additional cDNA sequence: AK022794.1 AK290224.1 AK308884.1 AL117479.1 AL157487.1 BC000246.1 HQ013232.1
14 DOTS entries : DT.85105418 DT.100788253
DT.100788259 DT.95173618 DT.95173623 DT.91848742 DT.95173619 DT.101961228 DT.100655018 DT.100704964 DT.121026877 DT.121026879 DT.121026889 DT.99937602 24/183 AceView cDNA sequences (see all 183 ):
CR592322 NM_015540 AU130626 BX283361 AI459998 Z43993 BQ054694 AL157487 BI333236 BM463433 CR610510 AA380621 BG397163 AL117479 BQ063149 CR609844 BQ936890 AI357581 BF984437 CB529762 AA306351 BI334382 AI250893 AU126901 GeneLoc Exon Structure 5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RPAP1 (see all 11 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · SP1 :   -   -       -     -               -                       -   SP2 :                                                     SP3 :                                                     SP4 :                                                   -   SP5 :     -       -     -                                      
ExUns: 17b · 17c ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b SP1 : -                         -           SP2 :                                   SP3 :                   -                 SP4 :                                   SP5 :                                  
ECgene alternative splicing isoforms for RPAP1
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Expression for RPAP1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RPAP1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCTGCTGGCA
About this image See RPAP1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPAP1 SOURCE GeneReport for Unigene cluster: Hs.371045 SABiosciences Custom PCR Arrays for RPAP1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RPAP1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat RPAP1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RPAP1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RPAP1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPAP1
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Orthologsfor RPAP1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPAP1 gene from 8/24 species (see all 24 ) About this table
ENSEMBL Gene Tree for RPAP1 (if available)TreeFam Gene Tree for RPAP1 (if available)
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Paralogsfor RPAP1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor RPAP1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 15 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RPAP1 (41809374 - 41836467 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for RPAP1 1 CNV : 29977
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RPAP1
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Disorders
/ Diseasesfor RPAP1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
RPAP1 for disorders About MalaCards
RPAP1 for disorders About GeneDecksing
OMIM gene information: 611475
OMIM disorders : --Human Genome Epidemiology (HuGE) Navigator: RPAP1 (1 document)Export disorders for RPAP1 gene to outside databases
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Publicationsfor RPAP1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RPAP1 gene, integrated from 9 sources (see all 21 ): (articles sorted by number of sources associating them with RPAP1) Utopia : connect your pdf to the dynamic world of online information
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198) 1 , 2 , 3 Nagase T.... Ohara O. (2000) RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits. (PubMed id 15282305) 1 , 2 , 9 Jeronimo C.... Coulombe B. (2004) Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375) 1 , 2 Jeronimo C.... Coulombe B. (2007) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950) 1 Lee O.H....Songyang Z. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010)
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External Searches for RPAP1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RPAP1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing RPAP1 gene
(According to HUGE )
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Specialized Databases showing RPAP1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for RPAP1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for RPAP1 gene: Search GeneIP for patents involving RPAP1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RPAP1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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variant library, vector shuttling OriGene Custom Antibody Services for RPAP1 OriGene Custom Protein Services for RPAP1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPAP1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RPAP1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RPAP1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RPAP1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RPAP1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RPAP1
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RPAP1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPAP1
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPAP1
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Aliases for RPAP1
Databases for RPAP1
Disorders / Diseases for RPAP1
Domains / Families for RPAP1
Drugs / Compounds for RPAP1
Expression for RPAP1
Function for RPAP1
Genomic Views for RPAP1
Intellectual Property for RPAP1
Orthologs for RPAP1
Paralogs for RPAP1
Pathways / Interactions for RPAP1
Products for RPAP1
Proteins for RPAP1
Publications for RPAP1
Search Box for RPAP1
Summaries for RPAP1
Transcripts for RPAP1
Variants for RPAP1
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