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RPAP1 Gene

protein-coding   GIFtS: 51
GCID: GC15M041809

RNA Polymerase II Associated Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA Polymerase II Associated Protein 11 2
KIAA14033 5
RNA Polymerase II-Associated Protein 12

External Ids:    HGNC: 245671   Entrez Gene: 260152   Ensembl: ENSG000001039327   OMIM: 6114755   UniProtKB: Q9BWH63   

Export aliases for RPAP1 gene to outside databases

Previous GC identifers: GC15M039526 GC15M039596 GC15M018657


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPAP1 Gene:
This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin
through its interaction with acetylated histones. (provided by RefSeq, Jul 2012)

GeneCards Summary for RPAP1 Gene:
RPAP1 (RNA polymerase II associated protein 1) is a protein-coding gene. GO annotations related to this gene include DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot: RPAP1_HUMAN, Q9BWH6
Function: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting
that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for
interaction of the RNA polymerase II complex with acetylated histone H3




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPAP1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPAP1 promoter sequence
   Search Chromatin IP Primers for RPAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q14

RPAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPAP1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M041809:  view genomic region     (about GC identifiers)

Start:
41,809,374 bp from pter      End:
41,836,467 bp from pter
Size:
27,094 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RPAP1_HUMAN, Q9BWH6 (See protein sequence)
Recommended Name: RNA polymerase II-associated protein 1  
Size: 1393 amino acids; 152755 Da
Subunit: Part of an RNA polymerase II complex that contains POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F,
POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, RPAP1, FCP1 plus the general transcription factors TFIIB and
TFIIF
Sequence caution: Sequence=BAA92641.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q9H9I2 Q9NSQ5 Q9P2E4 Q9UFS7
Alternative splicing: 3 isoforms:  Q9BWH6-1   Q9BWH6-2   Q9BWH6-3   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RPAP1: NX_Q9BWH6

Explore proteomics data for RPAP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys537, Lys1337
  • Modification sites at PhosphoSitePlus

  • See RPAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056355.2  
    ENSEMBL proteins: 
     ENSP00000456207   ENSP00000306123   ENSP00000455363   ENSP00000457203   ENSP00000455381  
     ENSP00000455527  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR013929 RNA_pol_II_AP1_C
     IPR013930 RNA_pol_II_AP1_N

    Graphical View of Domain Structure for InterPro Entry Q9BWH6

    ProtoNet protein and cluster: Q9BWH6

    UniProtKB/Swiss-Prot: RPAP1_HUMAN, Q9BWH6
    Similarity: Belongs to the RPAP1 family


    Find genes that share domains with RPAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPAP1_HUMAN, Q9BWH6
    Function: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting
    that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for
    interaction of the RNA polymerase II complex with acetylated histone H3

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003899DNA-directed RNA polymerase activity IEA--
    GO:0005488binding ----
         
    Find genes that share ontologies with RPAP1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPAP1
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    miRTarBase miRNAs that target RPAP1:
    hsa-mir-155-5p (MIRT020692), hsa-mir-296-3p (MIRT038350), hsa-mir-320a (MIRT044763), hsa-mir-92b-3p (MIRT040603), hsa-mir-18a-3p (MIRT040756), hsa-mir-98-5p (MIRT027585), hsa-let-7b-5p (MIRT052223)

    Block miRNA regulation of human, mouse, rat RPAP1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RPAP1:
    hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidRPAP1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RPAP1_HUMAN, Q9BWH6: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    nucleus2
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with RPAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPAP1
    Interactions:

        Search GeneGlobe Interaction Network for RPAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPAP1 (Q9BWH63 ENSP000003061234) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224774P678703, ENSP000004156154I2D: score=1 STRING: ENSP00000415615
    BAG6P463793, ENSP000003651314I2D: score=1 STRING: ENSP00000365131
    CSNK2BP678703I2D: score=1 
    ENSG00000096155P463793I2D: score=1 
    ENSG00000206406P678703I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPAP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPAP1 gene: 
    NM_015540.3  

    Unigene Cluster for RPAP1:

    RNA polymerase II associated protein 1
    Hs.371045  [show with all ESTs]
    Unigene Representative Sequence: NM_015540
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565167 ENST00000561603 ENST00000304330(uc001zod.3) ENST00000562303
    ENST00000564934 ENST00000565035 ENST00000561631 ENST00000568413 ENST00000563293
    ENST00000567866 ENST00000566863 ENST00000569829
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate RPAP1:
    hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidRPAP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RPAP1
    Predesigned siRNA for gene silencing in human, mouse, rat RPAP1
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    OriGene qSTAR qPCR primer pairs in human, mouse for RPAP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPAP1
      QuantiTect SYBR Green Assays in human, mouse, rat RPAP1
      QuantiFast Probe-based Assays in human, mouse, rat RPAP1

    Additional mRNA sequence: 

    AK022794.1 AK290224.1 AK308884.1 AL117479.1 AL157487.1 BC000246.1 HQ013232.1 

    14 DOTS entries:

    DT.85105418  DT.100788253  DT.100788259  DT.95173618  DT.95173623  DT.91848742  DT.95173619  DT.101961228 
    DT.100655018  DT.100704964  DT.121026877  DT.121026879  DT.121026889  DT.99937602 

    Selected AceView cDNA sequences (see all 183):

    AI459998 NM_015540 AL117479 BQ063149 BI333236 BQ936890 BG397163 BX283361 
    AU130626 CR592322 BQ054694 AA380621 Z43993 BM463433 AL157487 CR609844 
    CR610510 AI022310 BE780460 BQ642614 BE731829 BM697889 AL710640 BG106716 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPAP1 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a ·
    SP1:        -     -                 -           -                                         -                                                                 -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                        -   
    SP5:              -                 -           -                                                                                                               

    ExUns: 17b · 17c ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b
    SP1:  -                                                                       -                           
    SP2:                                                                                                      
    SP3:                                                        -                                             
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for RPAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGCTGGCA
    RPAP1 Expression
    About this image

    RPAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.371045
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RPAP1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpap11 , 5 RNA polymerase II associated protein 11, 5 82.66(n)1
    80.24(a)1
      2 (59.97 cM)5
    689251  NM_001163701.11  NP_001157173.11 
     1197633045 
    chicken
    (Gallus gallus)
    Aves RPAP11 RNA polymerase II associated protein 1 60.29(n)
    56.07(a)
      423217  XM_004941626.1  XP_004941683.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPAP16
    RNA polymerase II associated protein 1
    52(a)
    1 ↔ 1
    1(41278327-41338560)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ099668.12   -- 75.16(n)    BJ099668.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BG303798.12   -- 74.92(n)    BG303798.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG321046
    --
    26(a)
    1 ↔ 1
    3L(12386904-12392422)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RBA50(YDR527W)4 Protein involved in transcription; interacts with RNA more   --   4(1491094-1492413) 852139  NP_010816.1 


    ENSEMBL Gene Tree for RPAP1 (if available)
    TreeFam Gene Tree for RPAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPAP1 (see all 866)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364694
    A colorectal cancer sample4--see VAR_0364692 R Q mis40--------
    rs1866007841,2
    --41808889(+) CGTGGG/TGGCAC 1 -- ds50010--------
    rs1911504671,2
    --41808911(+) CCCAGC/TCACTC 1 -- ds50010--------
    rs2017400711,2
    C--41809028(+) CAGAA-/ATA   
       GATAG
    ATAGA
    1 -- ds50010--------
    rs3767431111,2
    C--41809028(+) CAGAA-/ATAG  
            
    ATAGA
    1 -- ds50010--------
    rs1477935161,2
    --41809053(+) ATAGAC/TAGATA 1 -- ds50010--------
    rs1412711561,2
    --41809057(+) ATAGAC/TAGATA 1 -- ds50010--------
    rs746102711,2
    C--41809073(+) ATAGAC/TAGACC 1 -- ds50010--------
    rs350325291,2
    C,F--41809074(+) TAGACC/AGACCG 1 -- ds50013Minor allele frequency- A:0.50NA 6
    rs795962491,2
    C--41809078(+) CAGACA/CGACCG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for RPAP1 (41809374 - 41836467 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RPAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2362n71CNV Loss21882294
    nsv524476CNV Loss19592680
    nsv471241CNV Loss18288195
    nsv904112CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611475    OMIM disorders: --


    Find genes that share disorders with RPAP1           About GenesLikeMe

    Genetic Association Database (GAD): RPAP1
    Human Genome Epidemiology (HuGE) Navigator: RPAP1 (1 document)

    Export disorders for RPAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPAP1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with RPAP1)
        Utopia: connect your pdf to the dynamic
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    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits. (PubMed id 15282305)1, 2, 9 Jeronimo C.... Coulombe B. (Mol. Cell. Biol. 2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1, 2 Jeronimo C.... Coulombe B. (Mol. Cell 2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26015 HGNC: 24567 AceView: RPAP1 Ensembl:ENSG00000103932 euGenes: HUgn26015
    ECgene: RPAP1 H-InvDB: RPAP1

    (According to HUGE)
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    HUGE: KIAA1403

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPAP1 gene:
    Search GeneIP for patents involving RPAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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