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Aliases for RPAIN Gene

Aliases for RPAIN Gene

  • RPA Interacting Protein 2 3 5
  • HRIP 3 4
  • RIP 3 4
  • RAP Interaction Protein 3
  • RPA-Interacting Protein 3
  • Nuclear Transporter 3

External Ids for RPAIN Gene

Previous GeneCards Identifiers for RPAIN Gene

  • GC17P005263

Summaries for RPAIN Gene

GeneCards Summary for RPAIN Gene

RPAIN (RPA Interacting Protein) is a Protein Coding gene. GO annotations related to this gene include protein complex binding.

UniProtKB/Swiss-Prot for RPAIN Gene

  • Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.

Gene Wiki entry for RPAIN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPAIN Gene

Genomics for RPAIN Gene

Regulatory Elements for RPAIN Gene

Enhancers for RPAIN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G005416 1.6 Ensembl ENCODE dbSUPER 41.1 -0.7 -691 4.7 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 ZNF302 RABEP1 RPAIN ENSG00000263272 C1QBP DHX33 LOC101927979 DERL2 NUP88 GC17P005414
GH17G005422 0.9 ENCODE dbSUPER 35.2 +3.1 3101 1.2 CTCF JUN MNT RAD21 JUND ZNF316 MAFF ZSCAN5C KDM1A MAFK RPAIN RABEP1 ENSG00000263272 NUP88
GH17G005437 1.1 ENCODE 23.9 +19.1 19105 2.9 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF207 ZNF143 FOS SP3 LOC101927979 RPAIN ZNF232 DERL2 MIS12 ENSG00000263272 LOC100130950 NUP88 DHX33 SPAG7
GH17G005525 1.5 FANTOM5 Ensembl ENCODE 13 +107.4 107406 3.2 PKNOX1 ATF1 INSM2 SIN3A KLF17 FEZF1 GLI4 RFX5 ZNF366 FOS NLRP1 RPAIN MIS12 DERL2 DHX33 LOC105371507 RNU7-31P
GH17G005484 1.1 ENCODE 14.4 +66.8 66814 3.1 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 RPAIN MIS12 NLRP1 ENSG00000263272 DHX33 NUP88 DERL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPAIN on UCSC Golden Path with GeneCards custom track

Promoters for RPAIN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090621 -41 2801 HDGF PKNOX1 FOXA2 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1

Genomic Location for RPAIN Gene

Chromosome:
17
Start:
5,419,641 bp from pter
End:
5,433,020 bp from pter
Size:
13,380 bases
Orientation:
Plus strand

Genomic View for RPAIN Gene

Genes around RPAIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPAIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPAIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPAIN Gene

Proteins for RPAIN Gene

  • Protein details for RPAIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UA6-RIP_HUMAN
    Recommended name:
    RPA-interacting protein
    Protein Accession:
    Q86UA6
    Secondary Accessions:
    • B4DI36
    • B4DTX7
    • E9PES3
    • J3KNH8
    • Q4G2Y0
    • Q4G2Y5
    • Q4G2Y8
    • Q6B4V9
    • Q6B4W0
    • Q6B4W1
    • Q6B4W4
    • Q86X49
    • Q9BT00

    Protein attributes for RPAIN Gene

    Size:
    219 amino acids
    Molecular mass:
    24784 Da
    Quaternary structure:
    • Interacts with the RPA1 subunit of RPA complex.

    Alternative splice isoforms for RPAIN Gene

neXtProt entry for RPAIN Gene

Post-translational modifications for RPAIN Gene

  • Isoform 2 is sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues.
  • Ubiquitination at Lys14 and isoforms=8171
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPAIN Gene

Domains & Families for RPAIN Gene

Protein Domains for RPAIN Gene

Suggested Antigen Peptide Sequences for RPAIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RPAIN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RPAIN Gene

Function for RPAIN Gene

Molecular function for RPAIN Gene

UniProtKB/Swiss-Prot Function:
Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.

Gene Ontology (GO) - Molecular Function for RPAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032403 protein complex binding IPI 16135809
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RPAIN: view
genes like me logo Genes that share phenotypes with RPAIN: view

Animal Model Products

CRISPR Products

miRNA for RPAIN Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPAIN Gene

Localization for RPAIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPAIN Gene

Isoform 1: Cytoplasm. Nucleus.
Isoform 2: Nucleus, PML body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPAIN gene
Compartment Confidence
nucleus 5
extracellular 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RPAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with RPAIN: view

Pathways & Interactions for RPAIN Gene

SuperPathways for RPAIN Gene

No Data Available

Pathways by source for RPAIN Gene

1 GeneTex pathway for RPAIN Gene

Gene Ontology (GO) - Biological Process for RPAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006261 DNA-dependent DNA replication IPI 16135809
GO:0006281 DNA repair IPI 16135809
GO:0006310 DNA recombination IPI 16135809
GO:0006606 protein import into nucleus IDA 16135809
genes like me logo Genes that share ontologies with RPAIN: view

No data available for SIGNOR curated interactions for RPAIN Gene

Drugs & Compounds for RPAIN Gene

No Compound Related Data Available

Transcripts for RPAIN Gene

Unigene Clusters for RPAIN Gene

RPA interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPAIN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for RPAIN Gene

GeneLoc Exon Structure for
RPAIN
ECgene alternative splicing isoforms for
RPAIN

Expression for RPAIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPAIN Gene

Protein differential expression in normal tissues from HIPED for RPAIN Gene

This gene is overexpressed in Breast (49.5) and CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPAIN Gene



Protein tissue co-expression partners for RPAIN Gene

NURSA nuclear receptor signaling pathways regulating expression of RPAIN Gene:

RPAIN

SOURCE GeneReport for Unigene cluster for RPAIN Gene:

Hs.462086

mRNA Expression by UniProt/SwissProt for RPAIN Gene:

Q86UA6-RIP_HUMAN
Tissue specificity: Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen.

Evidence on tissue expression from TISSUES for RPAIN Gene

  • Nervous system(4.6)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with RPAIN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPAIN Gene

Orthologs for RPAIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPAIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPAIN 34 35
  • 99.85 (n)
cow
(Bos Taurus)
Mammalia RPAIN 34 35
  • 86.15 (n)
dog
(Canis familiaris)
Mammalia RPAIN 34 35
  • 79.97 (n)
rat
(Rattus norvegicus)
Mammalia Rpain 34
  • 79.78 (n)
mouse
(Mus musculus)
Mammalia Rpain 34 16 35
  • 78.54 (n)
oppossum
(Monodelphis domestica)
Mammalia RPAIN 35
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPAIN 35
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPAIN 34 35
  • 63.05 (n)
lizard
(Anolis carolinensis)
Reptilia RPAIN 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpain 34
  • 54.6 (n)
zebrafish
(Danio rerio)
Actinopterygii rpain 34 35
  • 53.59 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3881 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
OneToOne
Species where no ortholog for RPAIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPAIN Gene

ENSEMBL:
Gene Tree for RPAIN (if available)
TreeFam:
Gene Tree for RPAIN (if available)

Paralogs for RPAIN Gene

No data available for Paralogs for RPAIN Gene

Variants for RPAIN Gene

Sequence variations from dbSNP and Humsavar for RPAIN Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000497587 -- 5,429,078(+) GGACT(-/CATTAA)CATTG intron-variant, nc-transcript-variant, cds-indel
rs1000595902 -- 5,429,664(+) TGACT(A/G)CAAGC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000649961 -- 5,429,276(+) CTGGA(C/T)AGACA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000811065 -- 5,422,386(+) TTTGC(C/T)TTATA intron-variant
rs1001097745 -- 5,422,095(+) GCCAA(C/T)GTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPAIN Gene

Variant ID Type Subtype PubMed ID
nsv474934 CNV novel sequence insertion 20440878
nsv574273 CNV gain 21841781

Variation tolerance for RPAIN Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.50; 71.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPAIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPAIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPAIN Gene

Disorders for RPAIN Gene

Relevant External Links for RPAIN

Genetic Association Database (GAD)
RPAIN
Human Genome Epidemiology (HuGE) Navigator
RPAIN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPAIN

No disorders were found for RPAIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPAIN Gene

Publications for RPAIN Gene

  1. Identification, expression pattern, and subcellular location of human RIP isoforms. (PMID: 16008515) Chen J.-Z. … Xue J.-L. (DNA Cell Biol. 2005) 2 3 4 22 64
  2. Sumoylation of the novel protein hRIPbeta is involved in replication protein A deposition in PML nuclear bodies. (PMID: 16135809) Park J. … Choe J. (Mol. Cell. Biol. 2005) 2 3 4 22 64
  3. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PMID: 19336370) Dagle J.M. … Murray J.C. (Pediatrics 2009) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RPAIN Gene

Sources for RPAIN Gene

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