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Aliases for RPAIN Gene

Aliases for RPAIN Gene

  • RPA Interacting Protein 2 3
  • HRIP 3 4
  • RIP 3 4
  • RAP Interaction Protein 3
  • RPA-Interacting Protein 3
  • Nuclear Transporter 3

External Ids for RPAIN Gene

Previous GeneCards Identifiers for RPAIN Gene

  • GC17P005263

Summaries for RPAIN Gene

GeneCards Summary for RPAIN Gene

RPAIN (RPA Interacting Protein) is a Protein Coding gene. GO annotations related to this gene include protein complex binding.

UniProtKB/Swiss-Prot for RPAIN Gene

  • Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.

Gene Wiki entry for RPAIN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPAIN Gene

Genomics for RPAIN Gene

Regulatory Elements for RPAIN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPAIN Gene

5,419,641 bp from pter
5,433,020 bp from pter
13,380 bases
Plus strand

Genomic View for RPAIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPAIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPAIN Gene

Proteins for RPAIN Gene

  • Protein details for RPAIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RPA-interacting protein
    Protein Accession:
    Secondary Accessions:
    • B4DI36
    • B4DTX7
    • E9PES3
    • J3KNH8
    • Q4G2Y0
    • Q4G2Y5
    • Q4G2Y8
    • Q6B4V9
    • Q6B4W0
    • Q6B4W1
    • Q6B4W4
    • Q86X49
    • Q9BT00

    Protein attributes for RPAIN Gene

    219 amino acids
    Molecular mass:
    24784 Da
    Quaternary structure:
    • Interacts with the RPA1 subunit of RPA complex.

    Alternative splice isoforms for RPAIN Gene

neXtProt entry for RPAIN Gene

Proteomics data for RPAIN Gene at MOPED

Post-translational modifications for RPAIN Gene

  • Isoform 2 is sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues.
  • Ubiquitination at Lys14, Lys22, and Lys171
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPAIN Gene

Domains for RPAIN Gene

Protein Domains for RPAIN Gene

Suggested Antigen Peptide Sequences for RPAIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q86UA6
  • Contains 1 RIP-type zinc finger.
genes like me logo Genes that share domains with RPAIN: view

No data available for Gene Families for RPAIN Gene

Function for RPAIN Gene

Molecular function for RPAIN Gene

UniProtKB/Swiss-Prot Function: Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.

Gene Ontology (GO) - Molecular Function for RPAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032403 protein complex binding IPI 16135809
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RPAIN: view

Animal Model Products

CRISPR Products

miRNA for RPAIN Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPAIN Gene

Localization for RPAIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPAIN Gene

Isoform 1: Cytoplasm. Nucleus.
Isoform 2: Nucleus, PML body.

Subcellular locations from

Jensen Localization Image for RPAIN Gene COMPARTMENTS Subcellular localization image for RPAIN gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RPAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with RPAIN: view

Pathways for RPAIN Gene

SuperPathways for RPAIN Gene

No Data Available

Interacting Proteins for RPAIN Gene

Gene Ontology (GO) - Biological Process for RPAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006261 DNA-dependent DNA replication IPI 16135809
GO:0006281 DNA repair IPI 16135809
GO:0006310 DNA recombination IPI 16135809
GO:0006606 protein import into nucleus IDA 16135809
GO:0009411 response to UV IDA 16135809
genes like me logo Genes that share ontologies with RPAIN: view

No data available for Pathways by source for RPAIN Gene

Transcripts for RPAIN Gene

Unigene Clusters for RPAIN Gene

RPA interacting protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPAIN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPAIN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: - - -
SP4: -

Relevant External Links for RPAIN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPAIN Gene

mRNA expression in normal human tissues for RPAIN Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPAIN Gene

SOURCE GeneReport for Unigene cluster for RPAIN Gene Hs.462086

mRNA Expression by UniProt/SwissProt for RPAIN Gene

Tissue specificity: Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen.
genes like me logo Genes that share expressions with RPAIN: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RPAIN Gene

Orthologs for RPAIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPAIN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPAIN 35
  • 99.85 (n)
  • 100 (a)
  • 97 (a)
(Bos Taurus)
Mammalia RPAIN 35
  • 86.15 (n)
  • 82.19 (a)
  • 79 (a)
(Canis familiaris)
Mammalia RPAIN 35
  • 79.97 (n)
  • 75.23 (a)
  • 57 (a)
(Mus musculus)
Mammalia Rpain 35
  • 78.54 (n)
  • 73.52 (a)
Rpain 16
Rpain 36
  • 71 (a)
(Monodelphis domestica)
Mammalia RPAIN 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia RPAIN 36
  • 36 (a)
(Rattus norvegicus)
Mammalia Rpain 35
  • 79.78 (n)
  • 76.3 (a)
(Gallus gallus)
Aves RPAIN 35
  • 63.05 (n)
  • 57.14 (a)
  • 52 (a)
(Anolis carolinensis)
Reptilia RPAIN 36
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpain 35
  • 54.6 (n)
  • 43.33 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3881 35
(Danio rerio)
Actinopterygii rpain 35
  • 53.59 (n)
  • 43.06 (a)
rpain 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for RPAIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPAIN Gene

Gene Tree for RPAIN (if available)
Gene Tree for RPAIN (if available)

Paralogs for RPAIN Gene

No data available for Paralogs for RPAIN Gene

Variants for RPAIN Gene

Sequence variations from dbSNP and Humsavar for RPAIN Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs10821 -- 5,428,144(-) TGTGG(A/G)GACAA reference, missense, intron-variant, nc-transcript-variant
rs12761 - 5,422,825(-) CCTTG(C/G)TTGAT reference, missense, nc-transcript-variant
rs1071648 -- 5,422,769(+) TCCAG(C/T)TGGAG reference, synonymous-codon, nc-transcript-variant
rs2005708 -- 5,430,326(+) gtcag(G/T)catgg intron-variant
rs2008284 -- 5,421,985(+) GTTTC(A/C)CCATG intron-variant

Relevant External Links for RPAIN Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPAIN Gene

Disorders for RPAIN Gene

(2) Novoseek inferred disease relationships for RPAIN Gene

Disease -log(P) Hits PubMed IDs
necrosis 8.15 3
tumors 0 1

Relevant External Links for RPAIN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RPAIN: view

No data available for UniProtKB/Swiss-Prot for RPAIN Gene

Publications for RPAIN Gene

  1. Identification, expression pattern, and subcellular location of human RIP isoforms. (PMID: 16008515) Chen J.-Z. … Xue J.-L. (DNA Cell Biol. 2005) 2 3 4 23
  2. Sumoylation of the novel protein hRIPbeta is involved in replication protein A deposition in PML nuclear bodies. (PMID: 16135809) Park J. … Choe J. (Mol. Cell. Biol. 2005) 2 3 4 23
  3. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PMID: 19336370) Dagle J.M. … Murray J.C. (Pediatrics 2009) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RPAIN Gene

Sources for RPAIN Gene

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