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Aliases for RPAIN Gene

Aliases for RPAIN Gene

  • RPA Interacting Protein 2 3 5
  • HRIP 3 4
  • RIP 3 4
  • RAP Interaction Protein 3
  • Nuclear Transporter 3

External Ids for RPAIN Gene

Previous GeneCards Identifiers for RPAIN Gene

  • GC17P005263

Summaries for RPAIN Gene

GeneCards Summary for RPAIN Gene

RPAIN (RPA Interacting Protein) is a Protein Coding gene. GO annotations related to this gene include protein complex binding.

UniProtKB/Swiss-Prot for RPAIN Gene

  • Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.

Gene Wiki entry for RPAIN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPAIN Gene

Genomics for RPAIN Gene

Regulatory Elements for RPAIN Gene

Enhancers for RPAIN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPAIN on UCSC Golden Path with GeneCards custom track

Promoters for RPAIN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPAIN on UCSC Golden Path with GeneCards custom track

Genomic Location for RPAIN Gene

Chromosome:
17
Start:
5,419,641 bp from pter
End:
5,433,020 bp from pter
Size:
13,380 bases
Orientation:
Plus strand

Genomic View for RPAIN Gene

Genes around RPAIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPAIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPAIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPAIN Gene

Proteins for RPAIN Gene

  • Protein details for RPAIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UA6-RIP_HUMAN
    Recommended name:
    RPA-interacting protein
    Protein Accession:
    Q86UA6
    Secondary Accessions:
    • B4DI36
    • B4DTX7
    • E9PES3
    • J3KNH8
    • Q4G2Y0
    • Q4G2Y5
    • Q4G2Y8
    • Q6B4V9
    • Q6B4W0
    • Q6B4W1
    • Q6B4W4
    • Q86X49
    • Q9BT00

    Protein attributes for RPAIN Gene

    Size:
    219 amino acids
    Molecular mass:
    24784 Da
    Quaternary structure:
    • Interacts with the RPA1 subunit of RPA complex.

    Alternative splice isoforms for RPAIN Gene

neXtProt entry for RPAIN Gene

Proteomics data for RPAIN Gene at MOPED

Post-translational modifications for RPAIN Gene

  • Isoform 2 is sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues.
  • Ubiquitination at Lys 14 and Lys 171
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPAIN Gene

Domains & Families for RPAIN Gene

Protein Domains for RPAIN Gene

Suggested Antigen Peptide Sequences for RPAIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UA6

UniProtKB/Swiss-Prot:

RIP_HUMAN :
  • Contains 1 RIP-type zinc finger.
Similarity:
  • Contains 1 RIP-type zinc finger.
genes like me logo Genes that share domains with RPAIN: view

No data available for Gene Families for RPAIN Gene

Function for RPAIN Gene

Molecular function for RPAIN Gene

UniProtKB/Swiss-Prot Function:
Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.

Gene Ontology (GO) - Molecular Function for RPAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RPAIN: view
genes like me logo Genes that share phenotypes with RPAIN: view

Animal Model Products

miRNA for RPAIN Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPAIN Gene

Localization for RPAIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPAIN Gene

Isoform 1: Cytoplasm. Nucleus.
Isoform 2: Nucleus, PML body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPAIN Gene COMPARTMENTS Subcellular localization image for RPAIN gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RPAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RPAIN: view

Pathways & Interactions for RPAIN Gene

SuperPathways for RPAIN Gene

No Data Available

Pathways by source for RPAIN Gene

1 GeneTex pathway for RPAIN Gene

Interacting Proteins for RPAIN Gene

Gene Ontology (GO) - Biological Process for RPAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006261 DNA-dependent DNA replication IPI 16135809
GO:0006281 DNA repair IPI 16135809
GO:0006606 protein import into nucleus IDA 16135809
genes like me logo Genes that share ontologies with RPAIN: view

No data available for SIGNOR curated interactions for RPAIN Gene

Drugs & Compounds for RPAIN Gene

No Compound Related Data Available

Transcripts for RPAIN Gene

Unigene Clusters for RPAIN Gene

RPA interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPAIN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for RPAIN Gene

GeneLoc Exon Structure for
RPAIN
ECgene alternative splicing isoforms for
RPAIN

Expression for RPAIN Gene

mRNA expression in normal human tissues for RPAIN Gene

Protein differential expression in normal tissues from HIPED for RPAIN Gene

This gene is overexpressed in Breast (49.5) and CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPAIN Gene



SOURCE GeneReport for Unigene cluster for RPAIN Gene Hs.462086

mRNA Expression by UniProt/SwissProt for RPAIN Gene

Q86UA6-RIP_HUMAN
Tissue specificity: Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen.
genes like me logo Genes that share expression patterns with RPAIN: view

Protein tissue co-expression partners for RPAIN Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RPAIN Gene

Orthologs for RPAIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPAIN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPAIN 35
  • 86.15 (n)
  • 82.19 (a)
RPAIN 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPAIN 35
  • 79.97 (n)
  • 75.23 (a)
RPAIN 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpain 35
  • 78.54 (n)
  • 73.52 (a)
Rpain 16
Rpain 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPAIN 35
  • 99.85 (n)
  • 100 (a)
RPAIN 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpain 35
  • 79.78 (n)
  • 76.3 (a)
oppossum
(Monodelphis domestica)
Mammalia RPAIN 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPAIN 36
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPAIN 35
  • 63.05 (n)
  • 57.14 (a)
RPAIN 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPAIN 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpain 35
  • 54.6 (n)
  • 43.33 (a)
zebrafish
(Danio rerio)
Actinopterygii rpain 35
  • 53.59 (n)
  • 43.06 (a)
rpain 36
  • 38 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3881 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToOne
Species with no ortholog for RPAIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPAIN Gene

ENSEMBL:
Gene Tree for RPAIN (if available)
TreeFam:
Gene Tree for RPAIN (if available)

Paralogs for RPAIN Gene

No data available for Paralogs for RPAIN Gene

Variants for RPAIN Gene

Sequence variations from dbSNP and Humsavar for RPAIN Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs12761 - 5,422,825(-) CCTTG(C/G)TTGAT nc-transcript-variant, reference, missense
rs10821 -- 5,428,144(-) TGTGG(A/G)GACAA intron-variant, nc-transcript-variant, reference, missense
rs1071648 -- 5,422,769(+) TCCAG(C/T)TGGAG nc-transcript-variant, reference, synonymous-codon
rs2189336 -- 5,422,842(+) CTAGT(A/G)GTAGT intron-variant
rs2189337 -- 5,422,858(+) CTTAC(C/T)TGTAT intron-variant

Variation tolerance for RPAIN Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.50; 71.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RPAIN Gene

Disorders for RPAIN Gene

Relevant External Links for RPAIN

Genetic Association Database (GAD)
RPAIN
Human Genome Epidemiology (HuGE) Navigator
RPAIN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPAIN

No disorders were found for RPAIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPAIN Gene

Publications for RPAIN Gene

  1. Identification, expression pattern, and subcellular location of human RIP isoforms. (PMID: 16008515) Chen J.-Z. … Xue J.-L. (DNA Cell Biol. 2005) 2 3 4 23 67
  2. Sumoylation of the novel protein hRIPbeta is involved in replication protein A deposition in PML nuclear bodies. (PMID: 16135809) Park J. … Choe J. (Mol. Cell. Biol. 2005) 2 3 23
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Elevated level of human RPA interacting protein I+ (hRIPI+) in cervical tumor cells is involved in cell proliferation through regulating RPA transport. (PMID: 23010595) Namkoong S. … Park J. (FEBS Lett. 2012) 3

Products for RPAIN Gene

Sources for RPAIN Gene

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