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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPA3 Gene

protein-coding   GIFtS: 62
GCID: GC07M007643

replication protein A3, 14kDa

(Previous name: replication protein A3 (14kD) )
 Explore 9 diseases affiliated with
RPA3 via our new
 Human Malady Compendium 
Biological research products
for RPA3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Replication Protein A3, 14kDa1 2     RP-A P142 3
REPA31 2 3     Replication Protein A3 (14kD)1
Replication Factor A Protein 32 3     Replication Protein A 14 KDa Subunit2
RF-A Protein 32 3     RPA143

External Ids:    HGNC: 102911   Entrez Gene: 61192   Ensembl: ENSG000001063997   OMIM: 1798375   UniProtKB: P352443   

Export aliases for RPA3 gene to outside databases

Previous GC identifers: GC07M007320 GC07M007420 GC07M007449


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RFA3_HUMAN, P35244
Function: Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded
DNA binding and protein interactions
Function: Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded
DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle
progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA
polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction
of nucleotide excision repair and RAD51-dependent strand exchange

Gene Wiki entry for RPA3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPA3 gene promoter:
         HOXA9B   HOXA9   ISGF-3   E47   POU2F1a   POU2F1b   Hand1   POU2F1c   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RPA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p21.3   HGNC chromosome: 7

RPA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPA3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M007643:  view genomic region     (about GC identifiers)

Start:
7,676,149 bp from pter      End:
7,758,238 bp from pter
Size:
82,090 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 7,723,782-7,804,410     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RFA3_HUMAN, P35244 (See protein sequence)
Recommended Name: Replication protein A 14 kDa subunit  
Size: 121 amino acids; 13569 Da
Subunit: Heterotrimer of 70, 32 and 14 kDa chains (canonical replication protein A complex). Component of the
alternative replication protein A complex (aRPA) composed of RPA1, RPA3 and RPA4. The DNA-binding activity may reside
exclusively on the 70 kDa subunit. Interacts with RPA4
Subcellular location: Nucleus
6 PDB 3D structures from and Proteopedia for RPA3:
1L1O (3D)        1QUQ (3D)        2PI2 (3D)        2PQA (3D)        2Z6K (3D)        3KDF (3D)    
Secondary accessions: Q549U6

Explore the universe of human proteins at neXtProt for RPA3: NX_P35244

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P35244

  • RPA3 Protein expression data from MOPED and PaxDb:    About this image 
    RPA3 Protein Expression
    REFSEQ proteins: NP_002938.1  
    ENSEMBL proteins: 
     ENSP00000223129   ENSP00000384652   ENSP00000379914   ENSP00000385383  
    Reactome Protein details: P35244
    Human Recombinant Protein Products for RPA3: 
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    Novus Biologicals RPA3 Proteins
    Novus Biologicals RPA3 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RPA3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005662DNA replication factor A complex TAS8454588
    GO:0005737cytoplasm IDA--

    RPA3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RPA3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012340 NA-bd_OB-fold
     IPR013970 Rep_factor-A_3

    Graphical View of Domain Structure for InterPro Entry P35244

    ProtoNet protein and cluster: P35244

    1 Blocks protein family: IPB013970 Replication factor A protein 3


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFA3_HUMAN, P35244
    Function: Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded
    DNA binding and protein interactions
    Function: Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded
    DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle
    progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA
    polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction
    of nucleotide excision repair and RAD51-dependent strand exchange

         Genatlas biochemistry entry for RPA3:
    replication protein A,subunit 3,component 14kDa of a trimeric single strand binding protein,involved in
    replication,homologous recombination and nucleotide excision repair,colocalizing with RAD51 on synapsed axes in
    meiosis and facilitating RAD51 function,also colocalizing with BLM in meiotic prophase of prophase nuclei of
    spermatocytes

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003697single-stranded DNA binding TAS8454588
    GO:0005515protein binding IPI19338310
         
    RPA3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RPA3:
     Bright nuclei  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RPA3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPA3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lagging Strand Synthesis
    8/15 pathways (see all 15)
    Lagging Strand Synthesis1.00
    Repair synthesis of patch ~27-30 bases long by DNA polymerase0.59
    Telomere C-strand (Lagging Strand) Synthesis0.91
    Repair synthesis for gap-filling by DNA polymerase in TC-NER0.59
    Extension of Telomeres0.83
    DNA replication0.56
    Processive synthesis on the lagging strand0.75
    Processive synthesis on the C-strand of the telomere0.55
    2Ubiquitinated Orc1 is degraded by the proteasome
    DNA Replication Pre-Initiation0.62
    DNA Replication0.49
    M/G1 Transition0.62
    Cell Cycle Checkpoints0.42
    Synthesis of DNA0.51
    S Phase0.40
    3Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)1.00
    Formation of incision complex in GG-NER0.61
    Nucleotide excision repair0.70
    Nucleotide Excision Repair Pathway0.49
    Dual incision reaction in GG-NER0.61
    4Assembly of the RAD51-ssDNA nucleoprotein complex
    Assembly of the RAD51-ssDNA nucleoprotein complex1.00
    Homologous DNA pairing and strand exchange0.83
    Presynaptic phase of homologous DNA pairing and strand exchange0.83
    Processing of DNA double-strand break ends0.60
    5Formation of Meiotic Holliday Junction
    Formation of Meiotic Holliday Junction1.00
    Formation of Meiotic Single-stranded DNA Invasion Complex0.83
    Formation of Meiotic Heteroduplex0.83
    Resolution of Meiotic Holliday Junction0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RPA3
        Cell cycle Start of DNA replication in early S phase

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RPA3
        Mismatch Repair in Eukaryotes
    DNA Repair Mechanisms
    Nucleotide Excision Repair Pathway

    1 GeneGo (Thomson Reuters) Pathway for RPA3
        Cell cycle Start of DNA replication in early S phase

    2 BioSystems Pathways for RPA3 
        G1 to S cell cycle control
    DNA Replication

    5/47        Reactome Pathways for RPA3 (see all 47)
        Telomere Maintenance
    Activation of ATR in response to replication stress
    Processing of DNA double-strand break ends
    S Phase
    Repair synthesis of patch ~27-30 bases long by DNA polymerase


    4         Kegg Pathways  (Kegg details for RPA3):
        DNA replication
    Nucleotide excision repair
    Mismatch repair
    Homologous recombination


    RPA3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/110 Interacting proteins for RPA3 (P352441, 2, 3 ENSP000002231294) via UniProtKB, MINT, STRING, and/or I2D (see all 110)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BLMP541322, 3, ENSP000003472324MINT-8049010 I2D: score=3 STRING: ENSP00000347232
    RPA1P276941, 3, ENSP000002547194EBI-1058317,EBI-621389 I2D: score=5 STRING: ENSP00000254719
    RPA2P159271, 3, ENSP000003630214EBI-1058317,EBI-621404 I2D: score=5 STRING: ENSP00000363021
    RAD52P433511, 3, ENSP000003512844EBI-1058317,EBI-706448 I2D: score=1 STRING: ENSP00000351284
    FYCO1Q9BQS83, ENSP000002961374I2D: score=3 STRING: ENSP00000296137
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000216M/G1 transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--

    RPA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPA3
    3 Novoseek chemical compound relationships for RPA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rpa 2 93 2 15197179 (1), 19812186 (1)
    nacl 19.3 2 10336450 (1)
    zinc 15.4 1 10856290 (1)

    Search CenterWatch for drugs/clinical trials and news about RPA3 / RFA3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPA3 gene: 
    NM_002947.3  

    Unigene Cluster for RPA3:

    Replication protein A3, 14kDa
    Hs.487540  [show with all ESTs]
    Unigene Representative Sequence: NM_002947
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000223129(uc003sri.3) ENST00000406109 ENST00000396682 ENST00000401447
    ENST00000483031 ENST00000462723 ENST00000463632

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    Additional cDNA sequence: 

    AK311842.1 BC005264.1 BC009868.2 BT007320.1 L07493.1 

    9 DOTS entries:

    DT.100653118  DT.215745  DT.92051068  DT.215744  DT.95155025  DT.96086278  DT.120940265  DT.86852453 
    DT.92428645 

    24/177 AceView cDNA sequences (see all 177):

    BM784626 BU633410 BQ654040 CB161679 AW949994 BF196375 CK905771 CR610107 
    BG770170 AA705038 CB111994 AA345343 F29051 BM907148 CD365270 BG107805 
    CB150584 AW264399 BI837475 BE559626 AI699352 BI910443 AA975429 BU927982 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RPA3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
    SP1:                                                  -     -                     
    SP2:                                      -                                       
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for RPA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTGATCTTG
    RPA3 Expression
    About this image
    See RPA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPA3

    SOURCE GeneReport for Unigene cluster: Hs.487540
        SABiosciences Expression via Pathway-Focused PCR Array including RPA3: 

              DNA Repair in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RPA3 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpa31 , 5 replication protein A31, 5 82.37(n)1
    76.86(a)1
      6 (3.53 cM)5
    682401  NM_026632.41  NP_080908.11 
     82559365 
    chicken
    (Gallus gallus)
    Aves RPA31 replication protein A3, 14kDa 70.4(n)
    69.83(a)
      420578  XM_418679.2  XP_418679.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPA36
    --
    61(a)
    1 ↔ 1
    6(23581037-23585110)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.73762 Xenopus laevis transcribed sequence with weak similarity more 72.66(n)    AW644185.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rpa31 replication protein A3 62.39(n)
    57.26(a)
      393196  NM_200227.1  NP_956521.1 


    ENSEMBL Gene Tree for RPA3 (if available)
    TreeFam Gene Tree for RPA3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPA3 gene

    RPA3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RPA3
    PGOHUM00000241022 PGOHUM00000243644


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1687 NCBI SNPs in RPA3 are shown (see all 1687    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs102801851,2
    C,F,H--7524777(+) GGGTAT/CCAAGG 1 -- int114Minor allele frequency- C:0.02NS EA NA 1050
    rs171691651,2
    C,F,H--7524898(+) AGTTTG/TTGCTT 1 -- int19Minor allele frequency- T:0.04NA NS EA WA 668
    rs287100551,2
    C,F--7524947(+) AGTACG/ATACCA 1 -- int16Minor allele frequency- A:0.04NS WA 260
    rs560684381,2
    C,F--7525099(+) CTCTAG/CGTTGG 1 -- int11Minor allele frequency- C:0.03WA 118
    rs289163151,2
    C,F--7525272(-) ATCCAT/CGACTT 2 /H syn16Minor allele frequency- C:0.00NS NA 4708
    rs791216791,2
    --7525603(+) TACTAC/TTTTTG 1 -- int10--------
    rs289163131,2
    C,F--7525757(-) ACTGCC/TACATT 1 -- int15Minor allele frequency- T:0.01NS 180
    rs558848681,2
    C--7525767(+) TACTAA/CAACTC 1 -- int10--------
    rs289163121,2
    C,F--7525792(-) TTTTAG/ATTTGA 1 -- int16Minor allele frequency- A:0.01NS WA 294
    rs557377451,2
    C--7525802(+) AATAAA/CACTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RPA3 (7676149 - 7758238 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for RPA3
         3 CNVs: 31332 8546 8547

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RPA3 for disorders           About GeneDecksing

    OMIM gene information: 179837    OMIM disorders: --

    9 diseases for RPA3:    About MalaCards
    bloom syndrome    chronic myeloid leukemia    fanconi's anemia    myeloid leukemia
    multiple sclerosis    anemia    meningioma    leukemia
    breast cancer

    Human Genome Epidemiology (HuGE) Navigator: RPA3 (10 documents)

    Export disorders for RPA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPA3 gene, integrated from 9 sources (see all 72):
    (articles sorted by number of sources associating them with RPA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A. (PubMed id 8454588)1, 2, 3 Umbricht C.B. and Kelly T.J. (1993)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA. (PubMed id 11927569)1, 2 Bochkareva E.... Bochkarev A. (2002)
    5. Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex. (PubMed id 7760808)1, 2 Keshav K.F.... Dutta A. (1995)
    6. The crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single-stranded DNA binding. (PubMed id 10449415)1, 9 Bochkarev A.... Edwards A.M. (1999)
    7. High-resolution genomic mapping of the three human replication protein A genes (RPA1, RPA2, and RPA3). (PubMed id 8020972)1, 9 Umbricht C.B....Kelly T.J. (1994)
    8. Dynamic light-scattering analysis of full-length human RPA14/32 dimer: purification, crystallization and self-association. (PubMed id 11173472)1, 9 Habel J.E....Borgstahl G.E. (2001)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6119 HGNC: 10291 AceView: RPA3 Ensembl:ENSG00000106399 euGenes: HUgn6119
    ECgene: RPA3 Kegg: 6119 H-InvDB: RPA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPA3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPA3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rpa3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPA3 gene:
    Search GeneIP for patents involving RPA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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