Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RPA3 Gene

protein-coding   GIFtS: 63
GCID: GC07M007643

Replication Protein A3, 14kDa

(Previous name: replication protein A3 (14kD))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Replication Protein A3, 14kDa1 2     RP-A P142 3
Replication Factor A Protein 32 3     Replication Protein A3 (14kD)1
REPA32 3     Replication Protein A 14 KDa Subunit2
RF-A Protein 32 3     RPA143

External Ids:    HGNC: 102911   Entrez Gene: 61192   Ensembl: ENSG000001063997   OMIM: 1798375   UniProtKB: P352443   

Export aliases for RPA3 gene to outside databases

Previous GC identifers: GC07M007320 GC07M007420 GC07M007449


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RPA3 Gene:
RPA3 (replication protein A3, 14kDa) is a protein-coding gene. Diseases associated with RPA3 include bloom syndrome, and fanconi's anemia. GO annotations related to this gene include single-stranded DNA binding.

UniProtKB/Swiss-Prot: RFA3_HUMAN, P35244
Function: Required for DNA recombination, repair and replication. The activity of RP-A is mediated by
single-stranded DNA binding and protein interactions
Function: Functions as component of the alternative replication protein A complex (aRPA). aRPA binds
single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and
cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha
but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual
incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange

Gene Wiki entry for RPA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPA3 gene promoter:
         HOXA9B   HOXA9   ISGF-3   E47   POU2F1a   POU2F1b   Hand1   POU2F1c   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RPA3 promoter sequence
   Search Chromatin IP Primers for RPA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p21.3   HGNC cytogenetic band: 7p21.3

RPA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPA3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M007643:  view genomic region     (about GC identifiers)

Start:
7,676,149 bp from pter      End:
7,758,238 bp from pter
Size:
82,090 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 7,723,782-7,804,410     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RFA3_HUMAN, P35244 (See protein sequence)
Recommended Name: Replication protein A 14 kDa subunit  
Size: 121 amino acids; 13569 Da
Subunit: Heterotrimer of 70, 32 and 14 kDa chains (canonical replication protein A complex). Component of the
alternative replication protein A complex (aRPA) composed of RPA1, RPA3 and RPA4. The DNA-binding activity may
reside exclusively on the 70 kDa subunit. Interacts with RPA4
6 PDB 3D structures from and Proteopedia for RPA3:
1L1O (3D)        1QUQ (3D)        2PI2 (3D)        2PQA (3D)        2Z6K (3D)        3KDF (3D)    
Secondary accessions: Q549U6

Explore the universe of human proteins at neXtProt for RPA3: NX_P35244

Explore proteomics data for RPA3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys23, Lys33, Lys39, Lys88
  • Modification sites at PhosphoSitePlus

  • See RPA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002938.1  
    ENSEMBL proteins: 
     ENSP00000223129   ENSP00000384652   ENSP00000379914   ENSP00000385383  
    Reactome Protein details: P35244

    RPA3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RPA3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RPA3
    GenScript Custom Purified and Recombinant Proteins Services for RPA3
    Novus Biologicals RPA3 Proteins
    Novus Biologicals RPA3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPA3

    RPA3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RPA3
    OriGene Custom Antibody Services for RPA3
    Novus Biologicals RPA3 Antibodies
    Abcam antibodies for RPA3
    Cloud-Clone Corp. Antibodies for RPA3
    ThermoFisher Antibodies for RPA3
    LSBio Antibodies in human, mouse, rat for RPA3

    RPA3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RPA3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RPA3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RPA3
    Cloud-Clone Corp. CLIAs for RPA3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR012340 NA-bd_OB-fold
     IPR013970 Rep_factor-A_3

    Graphical View of Domain Structure for InterPro Entry P35244

    ProtoNet protein and cluster: P35244

    1 Blocks protein domain: IPB013970 Replication factor A protein 3


    RPA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFA3_HUMAN, P35244
    Function: Required for DNA recombination, repair and replication. The activity of RP-A is mediated by
    single-stranded DNA binding and protein interactions
    Function: Functions as component of the alternative replication protein A complex (aRPA). aRPA binds
    single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and
    cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha
    but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual
    incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange

         Genatlas biochemistry entry for RPA3:
    replication protein A,subunit 3,component 14kDa of a trimeric single strand binding protein,involved in
    replication,homologous recombination and nucleotide excision repair,colocalizing with RAD51 on synapsed axes in
    meiosis and facilitating RAD51 function,also colocalizing with BLM in meiotic prophase of prophase nuclei of
    spermatocytes

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003697single-stranded DNA binding TAS8454588
    GO:0005515protein binding IPI10449415
         
    RPA3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RPA3:
     Bright nuclei  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPA3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPA3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPA3

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPA3:
    hsa-mir-26b-5p (MIRT029289), hsa-mir-615-3p (MIRT039841)

    Block miRNA regulation of human, mouse, rat RPA3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RPA3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RPA3
    Predesigned siRNA for gene silencing in human, mouse, rat RPA3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPA3

    Clone
    Products:
         
    OriGene clones in human, mouse for RPA3 (see all 6)
    OriGene ORF clones in mouse, rat for RPA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPA3 (NM_002947)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPA3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RPA3
    Browse ESI BIO Cell Lines and PureStem Progenitors for RPA3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RFA3_HUMAN, P35244: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton2
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005662DNA replication factor A complex TAS8454588
    GO:0005737cytoplasm ----

    RPA3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RPA3 About   (see all 16)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Telomere C-strand (Lagging Strand) Synthesis
    Gap-filling DNA repair synthesis and ligation in TC-NER0.94
    Removal of the Flap Intermediate from the C-strand0.00
    Repair synthesis of patch ~27-30 bases long by DNA polymerase0.94
    Lagging Strand Synthesis0.00
    Telomere C-strand (Lagging Strand) Synthesis0.79
    Removal of the Flap Intermediate0.00
    Extension of Telomeres0.79
    Processive synthesis on the C-strand of the telomere0.00
    2Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)0.69
    Formation of incision complex in GG-NER0.62
    Nucleotide excision repair0.69
    Nucleotide Excision Repair Pathway0.48
    Dual incision reaction in GG-NER0.62
    3Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.66
    Cell cycle Start of DNA replication in early S phase0.53
    DNA Replication0.66
    4E2F mediated regulation of DNA replication
    G1/S Transition0.81
    G1 to S cell cycle control0.35
    Mitotic G1-G1/S phases0.81
    5DNA strand elongation
    DNA strand elongation0.63
    DNA replication0.63

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RPA3
        Mismatch Repair in Eukaryotes
    DNA Repair Mechanisms
    Nucleotide Excision Repair Pathway

    1 GeneGo (Thomson Reuters) Pathway for RPA3
        Cell cycle Start of DNA replication in early S phase

    3 BioSystems Pathways for RPA3
        G1 to S cell cycle control
    DNA Replication
    RB in Cancer

    Selected Reactome Pathways for RPA3 (see all 14)
        Regulation of HSF1-mediated heat shock response
    Repair synthesis for gap-filling by DNA polymerase in TC-NER
    Activation of ATR in response to replication stress
    Removal of the Flap Intermediate
    Processing of DNA double-strand break ends


    5 Kegg Pathways  (Kegg details for RPA3):
        DNA replication
    Nucleotide excision repair
    Mismatch repair
    Homologous recombination
    Fanconi anemia pathway


    RPA3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including RPA3: 
              DNA Repair in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RPA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPA3 (P352441, 2, 3 ENSP000002231294) via UniProtKB, MINT, STRING, and/or I2D (see all 116)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BLMP541322, 3, ENSP000003472324MINT-8049010 I2D: score=3 STRING: ENSP00000347232
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    ENSG00000230336Q018603I2D: score=2 
    ENSG00000233911Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0000718nucleotide-excision repair, DNA damage removal TAS--
    GO:0000722telomere maintenance via recombination TAS--
    GO:0000723telomere maintenance TAS--

    RPA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPA3 (RFA3)

    3 Novoseek inferred chemical compound relationships for RPA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rpa 2 93 2 15197179 (1), 19812186 (1)
    nacl 19.3 2 10336450 (1)
    zinc 15.4 1 10856290 (1)



    RPA3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RPA3 gene: 
    NM_002947.3  

    Unigene Cluster for RPA3:

    Replication protein A3, 14kDa
    Hs.487540  [show with all ESTs]
    Unigene Representative Sequence: NM_002947
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000223129(uc003sri.3) ENST00000406109 ENST00000396682 ENST00000401447
    ENST00000483031 ENST00000462723 ENST00000463632
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RPA3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RPA3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RPA3
    Predesigned siRNA for gene silencing in human, mouse, rat RPA3
    Clone
    Products:
         
    OriGene clones in human, mouse for RPA3 (see all 6)
    OriGene ORF clones in mouse, rat for RPA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPA3 (NM_002947)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPA3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RPA3
    OriGene qSTAR qPCR primer pairs in human, mouse for RPA3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPA3
      QuantiTect SYBR Green Assays in human, mouse, rat RPA3
      QuantiFast Probe-based Assays in human, mouse, rat RPA3

    Additional mRNA sequence: 

    AK311842.1 BC005264.1 BC009868.2 BT007320.1 L07493.1 

    9 DOTS entries:

    DT.100653118  DT.215745  DT.92051068  DT.215744  DT.95155025  DT.96086278  DT.120940265  DT.86852453 
    DT.92428645 

    Selected AceView cDNA sequences (see all 177):

    CB161679 BF196375 BM784626 F29051 CB111994 CK905771 BG107805 AW949994 
    CR610107 BG770170 BU633410 CD365270 BM907148 AW264399 AA705038 CB150584 
    AA345343 BQ654040 AA907925 AI765604 BP432364 BQ216100 BG504381 N33011 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RPA3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
    SP1:                                                  -     -                     
    SP2:                                      -                                       
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for RPA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RPA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGATCTTG
    RPA3 Expression
    About this image

    RPA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.487540
        Pathway & Disease-focused RT2 Profiler PCR Array including RPA3: 
              DNA Repair in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RPA3
    OriGene qSTAR qPCR primer pairs in human, mouse for RPA3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPA3
    QuantiTect SYBR Green Assays in human, mouse, rat RPA3
    QuantiFast Probe-based Assays in human, mouse, rat RPA3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for RPA3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpa31 , 5 replication protein A31, 5 82.37(n)1
    76.86(a)1
      6 (3.53 cM)5
    682401  NM_026632.41  NP_080908.11 
     82559365 
    chicken
    (Gallus gallus)
    Aves RPA31 replication protein A3, 14kDa 69.42(n)
    66.94(a)
      420578  XM_418679.3  XP_418679.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPA36
    replication protein A3, 14kDa
    61(a)
    1 ↔ 1
    6(23581037-23585110)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.73762 Xenopus laevis transcribed sequence with weak similarity more 72.66(n)    AW644185.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rpa31 replication protein A3 62.39(n)
    57.26(a)
      393196  NM_200227.1  NP_956521.1 


    ENSEMBL Gene Tree for RPA3 (if available)
    TreeFam Gene Tree for RPA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RPA3 gene

    RPA3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RPA3
    PGOHUM00000241022 PGOHUM00000243644


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RPA3 (see all 1958)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1885685191,2
    --7647299(+) CGCCTC/TGGCCT 1 -- int10--------
    rs102801851,2
    C,F,H--7647395(+) GGGTAT/CCAAGG 1 -- int114Minor allele frequency- C:0.02NS EA NA 1050
    rs1917971931,2
    --7647513(+) TCAAGA/TTTGTG 1 -- int10--------
    rs171691651,2
    C,F,H--7647516(+) AGTTTG/TTGCTT 1 -- int19Minor allele frequency- T:0.04NA NS EA WA 668
    rs174667371,2
    C,F,H--7647557(+) TGACCG/AATAGT 1 -- int122Minor allele frequency- A:0.08NA NS EA 1916
    rs287100551,2
    C,F--7647565(+) AGTACG/ATACCA 1 -- int16Minor allele frequency- A:0.04NS WA 260
    rs1843829891,2
    --7647568(+) ACGTAC/TCATTT 1 -- int10--------
    rs1901586481,2
    --7647594(+) AAATAC/GAAACT 1 -- int10--------
    rs1823958061,2
    --7647634(+) TCTAAC/TCTGAC 1 -- int10--------
    rs1873312081,2
    --7647647(+) TATATC/TGGAGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RPA3 (7676149 - 7758238 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RPA3 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2733939CNV Deletion23290073
    esv1554962CNV Insertion17803354
    esv1736638CNV Insertion17803354
    nsv887487CNV Loss21882294
    nsv887486CNV Loss21882294
    dgv7161n71CNV Loss21882294
    esv2752177CNV Gain17911159
    nsv887483CNV Gain21882294
    dgv7158n71CNV Gain21882294
    nsv887484CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPA3
    DNA2.0 Custom Variant and Variant Library Synthesis for RPA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 179837    OMIM disorders: --

    10 diseases for RPA3:    About MalaCards
    bloom syndrome    fanconi's anemia    chronic myeloid leukemia    meningioma
    multiple sclerosis    myeloid leukemia    leukemia    hiv-1
    breast cancer    neuronitis


    RPA3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RPA3
    Human Genome Epidemiology (HuGE) Navigator: RPA3 (10 documents)

    Export disorders for RPA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RPA3 gene, integrated from 10 sources (see all 76):
    (articles sorted by number of sources associating them with RPA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A. (PubMed id 8454588)1, 2, 3 Umbricht C.B. and Kelly T.J. (J. Biol. Chem. 1993)
    2. Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. (PubMed id 20496165)1, 4 Monsees G.M....Han J. (Breast Cancer Res. Treat. 2011)
    3. Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)1, 4 Briggs F.B....Barcellos L.F. (Am. J. Epidemiol. 2010)
    4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    5. XPC genetic polymorphisms correlate with the response to imatinib treatment in patients with chronic phase chronic myeloid leukemia. (PubMed id 20575039)1, 4 Guillem V.M....HernA!ndez-Boluda J.C. (Am. J. Hematol. 2010)
    6. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)
    7. Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers. (PubMed id 17494052)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2007)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    10. Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA. (PubMed id 11927569)1, 2 Bochkareva E.... Bochkarev A. (EMBO J. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6119 HGNC: 10291 AceView: RPA3 Ensembl:ENSG00000106399 euGenes: HUgn6119
    ECgene: RPA3 Kegg: 6119 H-InvDB: RPA3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RPA3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPA3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rpa3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RPA3 gene:
    Search GeneIP for patents involving RPA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RPA3   OriGene RNAi products in human, mouse, rat for RPA3  
     OriGene qPCR primer pairs and template standards for RPA3   OriGene Protein Over-expression Lysate for RPA3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RPA3  
     OriGene qSTAR qPCR primer pairs in human, mouse for RPA3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RPA3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPA3   OriGene Custom Protein Services for RPA3  

     
     
     Block miRNA regulation of human, mouse, rat RPA3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RPA3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPA3 Predesigned siRNA for gene silencing in human, mouse, rat RPA3
     QuantiFast Probe-based Assays in human, mouse, rat RPA3 QuantiTect SYBR Green Assays in human, mouse, rat RPA3
     PCR Arrays including human, mouse, rat RPA3 Search Chromatin IP Primers for RPA3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPA3  GeneGlobe Interaction Network for RPA3
     Regulatory tfbs in RPA3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RPA3 GenScript cDNA clones with any tag delivered in your preferred vector for RPA3
     GenScript Custom Assay Services for RPA3 GenScript Custom overexpressing Cell Line Services for RPA3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RPA3 (RFA3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RPA3 antibodies
     RPA3 proteins
     RPA3 lysates
     Antibodies for RPA3
     See all of Abcam's Antibodies, Kits and Proteins for RPA3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RPA3
     Antibodies for RPA3
     ELISAs for RPA3
     CLIAs for RPA3



     Browse ESI BIO Cell Lines and PureStem Progenitors for RPA3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPA3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RPA3
     SwitchGear Promoter luciferase reporter plasmids for RPA3
     ThermoFisher Antibodies for RPA3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPA3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPA3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPA3
     LSBio Antibodies in human, mouse, rat for RPA3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RPA3 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4