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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPA2 Gene

protein-coding GIFtS: 69
GCID: GC01M028218

replication protein A2, 32kDa

(Previous name: replication protein A2 (32kD) )

Explore 23 diseases affiliated with
RPA2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Replication Protein A2, 32kDa¹ ²		RP-A P32² ³
Replication Factor A Protein 2² ³		RP-A P34² ³
Replication Protein A 34 KDa Subunit² ³		Replication Protein A2 (32kD)¹
REPA2² ³		Replication Protein A 32 KDa Subunit²
RPA32² ³		RPA34³
RF-A Protein 2² ³

External Ids:	HGNC: 10290¹	Entrez Gene: 6118²	Ensembl: ENSG00000117748⁷	OMIM: 179836⁵	UniProtKB: P15927³

Export aliases for RPA2 gene to outside databases

Previous GC identifers: GC01P027225 GC01M027451 GC01M027822 GC01M027902 GC01M028090 GC01M026473

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RFA2_HUMAN, P15927

Function: Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded

DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair

factor RAD51 to chromatin in response to DNA damage

Function: Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded

DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle

progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA

polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction

of nucleotide excision repair and RAD51-dependent strand exchange

Gene Wiki entry for RPA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPA2 gene promoter:
HEN1 PPAR-alpha CREB deltaCREB AP-4 MRF-2 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPA2 promoter sequence

Search SABiosciences Chromatin IP Primers for RPA2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPA2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35 Ensembl cytogenetic band: 1p35.3 HGNC cytogenetic band: 1p35

RPA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPA2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M028218: view genomic region (about GC identifiers)

Start:	28,218,035 bp from pter	End:	28,241,257 bp from pter
Size:	23,223 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RFA2_HUMAN, P15927 (See protein sequence)

Recommended Name: Replication protein A 32 kDa subunit

Size: 270 amino acids; 29247 Da

Subunit: Heterotrimer of 70, 32 and 14 kDa chains (canonical replication protein A complex). Component of the

alternative replication protein A complex (aRPA) composed of RPA1, RPA3 and RPA4. The DNA-binding activity may reside

exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN. Directly interacts with PPP4R2, but

not with SMEK2; this interaction is DNA damage-dependent and leads RPA2 dephosphorylation by PPP4C recruitment.

Interacts with RAD51, preferentially when hyperphosphorylated. Directly interacts with RFWD3

Subcellular location: Nucleus. Nucleus, PML body. Note=Also present in PML nuclear bodies. Redistributes to discrete

nuclear foci upon DNA damage

6/8 PDB 3D structures from and Proteopedia for RPA2 (see all 8):

1DPU (3D)

1L1O (3D)

1QUQ (3D)

1Z1D (3D)

2PI2 (3D)

2PQA (3D)

Secondary accessions: Q52II0 Q5TEI9 Q5TEJ5

Alternative splicing: 3 isoforms: P15927-1 P15927-2 P15927-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RPA2: NX_P15927

Post-translational modifications:

Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis). In response to DNA damage, recruited

to DNA-repair nuclear foci, as a hypophosphorylated form. The necessary dephosphorylation step is catalyzed by PP4.

Subsequent hyperphosphorylation, catalyzed by ATR, is required for RAD51 recruitment to chromatin and efficient DNA

repair. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA, and by CDK1. Phosphorylation at

Thr-21 depends upon RFWD3 presence¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P15927

RPA2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002937.1

ENSEMBL proteins:

ENSP00000363021 ENSP00000413541 ENSP00000363017 ENSP00000363015 ENSP00000387649

Reactome Protein details: P15927
Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for RPA2
	Uscn Proteins for RPA2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005662	DNA replication factor A complex	IPI	16135809
GO:0005730	NOT nucleolus	IDA	--
GO:0016605	PML body	IEA	--

RPA2 for ontologies About GeneDecksing

RPA2 Antibody Products:

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	OriGene Antibodies (see all 12): RPA2 OriGene Custom Antibody Services for RPA2
	GenScript Custom Superior Antibodies Services for RPA2
	Novus Biologicals RPA2 Antibodies
	Abcam antibodies for RPA2
	Uscn Antibodies for RPA2
	ThermoFisher Antibody for RPA2

Assay Products for RPA2:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RPA2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RPA2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPA2 for domains About GeneDecksing

5 InterPro domains/families:

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR012340 NA-bd_OB-fold

IPR014646 RPA32

IPR004365 NA-bd_OB_tRNA-helicase

IPR014892 RPA_C

Graphical View of Domain Structure for InterPro Entry P15927

ProtoNet protein and cluster: P15927

1 Blocks protein family: IPB004365 OB-fold nucleic acid binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RFA2_HUMAN, P15927

Function: Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded

DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair

factor RAD51 to chromatin in response to DNA damage

Function: Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded

DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle

progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA

polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction

of nucleotide excision repair and RAD51-dependent strand exchange

Genatlas biochemistry entry for RPA2:

replication protein A,subunit 2,component of a trimeric single strand binding protein,involved in

replication,homologous recombination and nucleotide excision repair,colocolizing with RAD51 on synapsed axes in

meiosis and facilitating RAD51 function,also colocalizing with BLM in meiotic prophase of prophase nuclei of

spermatocytes

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPA2
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate RPA2 (see all 22):
		hsa-miR-106a hsa-let-7a-2* hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-let-7g* hsa-miR-526b* hsa-miR-17

		SwitchGear 3'UTR luciferase reporter plasmid: RPA2 3' UTR sequence

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Gene Editing
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DNA2.0 Custom Protein Engineering Service for RPA2

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPA2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	--	--
GO:0003697	single-stranded DNA binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0019903	protein phosphatase binding	IPI	--

RPA2 for ontologies About GeneDecksing

7 GenomeRNAi human phenotypes for RPA2:

Bright nuclei	Decreased viability	Decreased viability of wild-ty	Increased S DNA content, incre
Increased gamma-H2AX phosphory	S arrest	Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Lagging Strand Synthesis

8/15 pathways (see all 15)
Lagging Strand Synthesis	1.00	Repair synthesis of patch ~27-30 bases long by DNA polymerase	0.59
Telomere C-strand (Lagging Strand) Synthesis	0.91	Repair synthesis for gap-filling by DNA polymerase in TC-NER	0.59
Extension of Telomeres	0.83	DNA replication	0.56
Processive synthesis on the lagging strand	0.75	Processive synthesis on the C-strand of the telomere	0.55

Ubiquitinated Orc1 is degraded by the proteasome

DNA Replication Pre-Initiation	0.62	DNA Replication	0.49
M/G1 Transition	0.62	Cell Cycle Checkpoints	0.42
Synthesis of DNA	0.51	S Phase	0.40

Global Genomic NER (GG-NER)

Global Genomic NER (GG-NER)	1.00	Formation of incision complex in GG-NER	0.61
Nucleotide excision repair	0.70	Nucleotide Excision Repair Pathway	0.49
Dual incision reaction in GG-NER	0.61

Assembly of the RAD51-ssDNA nucleoprotein complex

	Assembly of the RAD51-ssDNA nucleoprotein complex	1.00			Homologous DNA pairing and strand exchange	0.83
	Presynaptic phase of homologous DNA pairing and strand exchange	0.83			Processing of DNA double-strand break ends	0.60

Formation of Meiotic Holliday Junction

	Formation of Meiotic Holliday Junction	1.00			Formation of Meiotic Single-stranded DNA Invasion Complex	0.83
	Formation of Meiotic Heteroduplex	0.83			Resolution of Meiotic Holliday Junction	0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for RPA2

Cell cycle Start of DNA replication in early S phase

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RPA2

	Mismatch Repair in Eukaryotes
	DNA Repair Mechanisms
	Nucleotide Excision Repair Pathway

2 Cell Signaling Technology (CST) Pathways for RPA2

	Cell Cycle / Checkpoint Control
	DNA Damage

1 GeneGo (Thomson Reuters) Pathway for RPA2

Cell cycle Start of DNA replication in early S phase

3 BioSystems Pathways for RPA2

	DNA damage response
	G1 to S cell cycle control
	DNA Replication

5/47 Reactome Pathways for RPA2 (see all 47)

	Telomere Maintenance
	Activation of ATR in response to replication stress
	Processing of DNA double-strand break ends
	S Phase
	Repair synthesis of patch ~27-30 bases long by DNA polymerase

4 Kegg Pathways (Kegg details for RPA2):

	DNA replication
	Nucleotide excision repair
	Mismatch repair
	Homologous recombination

RPA2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RPA2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/100 Interacting proteins for RPA2 (P15927^{1, 2, 3} ENSP00000363021⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 100)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPA3	P35244¹^,³, ENSP00000223129⁴	EBI-621404,EBI-1058317 I2D: score=5 STRING: ENSP00000223129
GAPDH	P04406¹^,³	EBI-621404,EBI-354056 I2D: score=4
WRN	Q14191²^,³, ENSP00000298139⁴	MINT-8048594 MINT-8048571 I2D: score=1 STRING: ENSP00000298139
RPA1	P27694¹^,³, ENSP00000254719⁴	EBI-621404,EBI-621389 I2D: score=5 STRING: ENSP00000254719
XPA	P23025¹^,³, ENSP00000364270⁴	EBI-621404,EBI-295222 I2D: score=4 STRING: ENSP00000364270

About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--

RPA2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RPA2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RPA2
10/17 Novoseek chemical compound relationships for RPA2 gene (see all 17) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rpa 2	98.3	167	11731442 (9), 20130019 (8), 16483312 (8), 19671522 (7) (see all 39)
adozelesin	73.6	9	12533671 (4), 14643438 (2)
camptothecin	72.1	30	16483312 (7), 10064605 (4), 15856006 (3), 15060176 (2) (see all 6)
aphidicolin	69.7	9	14643438 (3), 15661754 (2), 12533671 (1), 15938632 (1)
7-hydroxystaurosporine	65.2	1	10064605 (1)
hydroxyurea	54.9	23	14643438 (3), 20130019 (3), 19704001 (2), 16483312 (2) (see all 5)
etoposide	31.2	2	10064605 (1), 19787780 (1)
threonine	19	1	19704001 (1)
wortmannin	15.9	1	11731442 (1)
caffeine	15.3	2	15060176 (1), 11731442 (1)

Search CenterWatch for drugs/clinical trials and news about RPA2 / RFA2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RPA2 gene:

NM_002946.3

Unigene Cluster for RPA2:

Replication protein A2, 32kDa

Hs.79411 [show with all ESTs]

Unigene Representative Sequence: NM_002946

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373912(uc001bpe.1 uc010ofp.1) ENST00000419958 ENST00000373909

ENST00000313433 ENST00000444045

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		hsa-miR-106a hsa-let-7a-2* hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-let-7g* hsa-miR-526b* hsa-miR-17

		SwitchGear 3'UTR luciferase reporter plasmid: RPA2 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPA2

Additional cDNA sequence:

AK298759.1 AK300691.1 AK312956.1 BC001630.1 BC012157.1 BC021257.2 CR450348.1 J05249.1

14 DOTS entries:

DT.418275 DT.91764464 DT.121459182 DT.121459150 DT.121459217 DT.95201704 DT.97859731 DT.91764463

DT.95201728 DT.121459157 DT.121459229 DT.91764450 DT.95201706 DT.95201730

24/382 AceView cDNA sequences (see all 382):

BP369294 BG231596 BE019650 BM669612 BI261314 BX442975 AI864261 BQ641985

BF725783 BQ668543 BE294795 CR594823 BQ064852 F04735 BE394497 AA226830

BE297131 BM678855 BQ083162 BQ059808 BM839986 BQ943330 BQ063763 BM312300

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for RPA2 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9
SP1:					-		-
SP2:
SP3:							-

ECgene alternative splicing isoforms for RPA2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTTCTGCG

About this image
See RPA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPA2

SOURCE GeneReport for Unigene cluster: Hs.79411

SABiosciences Custom PCR Arrays for RPA2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPA2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPA2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPA2 gene from 8/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RPA2¹	replication protein A2, 32kDa	66.79(n) 70.04(a)		419566 NM_001030892.1 NP_001026063.1
lizard (Anolis carolinensis)	Reptilia	--	--	64(a)	1 → many	GL343743.1(52034-58750)
African clawed frog (Xenopus laevis)	Amphibia	Xl.5629²	Xenopus laevis transcribed sequence with weak similarity more	77.92(n)		CA972904.1
zebrafish (Danio rerio)	Actinopterygii	rpa2²	replication protein A2	75.54(n)		65226 AY007304.1
fruit fly (Drosophila melanogaster)	Insecta	RPA2¹	Replication protein A2	44.02(n) 32.91(a)		35364 NM_136233.2 NP_610077.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RFA2(YNL312W)⁴ RFA2¹	Subunit of heterotrimeric Replication Protein A (RPA), more⁴ Rfa2p¹	41.84(n)¹ 31.28(a)¹		14(48287-49216)⁴ 855404^{1, 4} NP_014087.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	RPA2¹	replicon protein A2	44.71(n) 32.53(a)		816985 NM_128010.2 NP_565571.1
rice (Oryza sativa)	Liliopsida	Os02g0829100¹	hypothetical protein	43.85(n) 32.37(a)		4331236 NM_001055139.1 NP_001048604.1

ENSEMBL Gene Tree for RPA2 (if available)
TreeFam Gene Tree for RPA2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RPA2 gene

RPA4²

1 SIMAP similar gene for RPA2 using alignment to 3 protein entries: RFA2_HUMAN (see all proteins):

RPA4

RPA2 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for RPA2
PGOHUM00000238566 PGOHUM00000242874 PGOHUM00000248155

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs180934934^1,2		--	28217607(+)	`TTCAGA/GAGTTG`	1	--	int¹		0	--	--	--	--
rs17162868^1,2	C,F,H,	--	28217614(+)	`GTTGTC/GAAAAA`	1	--	int¹		21		NA NS EA	1490
rs184308544^1,2		--	28217741(+)	`TTACAC/TGATCA`	1	--	int¹		0	--	--	--	--
rs11800603^1,2	C,F,H,	--	28217914(+)	`TGACAT/CAGCCT`	1	--	int¹		11		NS EA NA WA	702
rs188726817^1,2		--	28218050(+)	`TTACTA/GCAATA`	1	--	ut3¹		0	--	--	--	--
rs28904910^1,2	C,	--	28218088(-)	`ACAAAA/GTAAAT`	1	--	ut3¹		5		NS	190
rs148647706^1,2		--	28218101(+)	`AAAATA/GCAGTA`	1	--	ut3¹		0	--	--	--	--
rs117953042^1,2		--	28218246(+)	`CAAAGT/GGGGAA`	1	--	ut3¹		1		EA	120
rs28904909^1,2	C,F,H	--	28218312(-)	`AGCAGG/AACCAG`	1	--	ut3¹ ese³		7		NS NA	416
rs142124527^1,2		--	28218330(+)	`CAGCAC/GTAAAC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RPA2 (28218035 - 28241257 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RPA2
1 CNV: 84149
Human Gene Mutation Database (HGMD): RPA2

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RPA2 for disorders           About GeneDecksing

OMIM gene information: 179836    OMIM disorders: --

20/23 diseases for RPA2 (see all 23):    About MalaCards

xeroderma pigmentosum, group a xeroderma pigmentosum nijmegen breakage syndrome ataxia telangiectasia

oral squamous cell carcinoma squamous cell carcinoma bloom syndrome fanconi's anemia

neuroendocrine tumor familial melanoma colon cancer multiple sclerosis

ataxia breast cancer anemia melanoma

lung cancer carcinoma leukemia neuroblastoma

1 disease from the University of Copenhagen DISEASES database for RPA2:

Ataxia telangiectasia

9 Novoseek disease relationships for RPA2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ataxia telangiectasia	77.2	8	16483312 (2), 14872059 (1), 19339345 (1), 9270001 (1) (see all 5)
xeroderma pigmentosum	42.2	1	10340474 (1)
promyelocytic leukemia	29.6	1	12814551 (1)
colon cancer	0	3	17361204 (3)
breast cancer	0	1	11895905 (1)
metastasis	0	2	17361204 (1)
tumors	0	8	11895905 (2), 17970065 (1), 17361204 (1)
carcinoma	0	3	11895905 (1), 17361204 (1)
cancer	0	2	15856006 (1), 11895905 (1)

Human Genome Epidemiology (HuGE) Navigator: RPA2 (6 documents)

Export disorders for RPA2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RPA2 gene, integrated from 9 sources (see all 193):
(articles sorted by number of sources associating them with RPA2)

Utopia: connect your pdf to the dynamic
world of online information

A PP4 phosphatase complex dephosphorylates RPA2 to fa cilitate DNA repair via homologous recombination. (PubMed id 20154705)^{1, 2, 9} Lee D.H....Chowdhury D. (2010)
ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation. (PubMed id 12814551)^{1, 2, 9} Barr S.M.... Cimprich K.A. (2003)
RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A. (PubMed id 10982866)^{1, 2, 9} Cho J.M....Alaoui-Jamali M.A. (2000)
Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA. (PubMed id 11927569)^{1, 2, 9} Bochkareva E.... Bochkarev A. (2002)
E3 ligase RFWD3 participates in replication checkpoin t control. (PubMed id 21504906)^{1, 2} Gong Z. and Chen J. (2011)
RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response. (PubMed id 21558276)^{1, 2} Liu S.... Wang Y. (2011)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Coordinated regulation of replication protein A activities by its subunits p14 and p32. (PubMed id 15205463)^{1, 2} Weisshart K.... Nasheuer H.-P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA. (PubMed id 11081631)^{1, 2} Mer G.... Chazin W.J. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6118	HGNC: 10290	AceView: RPA2	Ensembl:ENSG00000117748	euGenes: HUgn6118
ECgene: RPA2	Kegg: 6118	H-InvDB: RPA2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RPA2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RPA2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/rpa2/

Intellectual Property for RPA2 gene
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Patent Information for RPA2 gene:
Search GeneIP for patents involving RPA2

GeneCards and IP:
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replication protein A2, 32kDa

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RPA2 Gene

replication protein A2, 32kDa

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