Aliases for RPA2 Gene
External Ids for RPA2 Gene
Previous GeneCards Identifiers for RPA2 Gene
GeneCards Summary for RPA2 Gene
RPA2 (Replication Protein A2) is a Protein Coding gene. Diseases associated with RPA2 include Xeroderma Pigmentosum, Group A and Ataxia-Telangiectasia. Among its related pathways are Cell Cycle Checkpoints and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include nucleic acid binding and ubiquitin protein ligase binding. An important paralog of this gene is RPA4.
UniProtKB/Swiss-Prot for RPA2 Gene
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.