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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPA1 Gene

protein-coding   GIFtS: 67
GCID: GC17P001680

replication protein A1, 70kDa

(Previous name: replication protein A1 (70kD) )
 Explore 42 diseases affiliated with
RPA1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RPA1    

Aliases
for RPA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Replication Protein A1, 70kDa1 2     Single-Stranded DNA-Binding Protein2 3
REPA11 2 3     RF-A Protein 12 3
RPA701 2 3     RP-A P702 3
HSSB1 2     Replication Protein A1 (70kD)1
RF-A1 2     MST0752
RP-A1 2     MSTP0752
Replication Factor A Protein 12 3     Replication Protein A 70 KDa DNA-Binding Subunit2

External Ids:    HGNC: 102891   Entrez Gene: 61172   Ensembl: ENSG000001323837   OMIM: 1798355   UniProtKB: P276943   

Export aliases for RPA1 gene to outside databases

Previous GC identifers: GC17P002039 GC17P001684 GC17P001939


Summaries
for RPA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: RFA1_HUMAN, P27694
Function: Plays an essential role in several cellular processes in DNA metabolism including replication, recombination
and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary
DNA from reannealing
Function: Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded
DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle
progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA
polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction
of nucleotide excision repair and RAD51-dependent strand exchange

Gene Wiki entry for RPA1 (Replication protein A1)


Genomic Views
for RPA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPA1 gene promoter:
         MAZR   CBF-C   CREB   CBF-A   CBF-B   deltaCREB   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

RPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPA1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P001680:  view genomic region     (about GC identifiers)

Start:
 1,732,996 bp from pter      End:
 1,803,376 bp from pter
Size:
 70,381 bases      Orientation:
 plus strand

Proteins
for RPA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RFA1_HUMAN, P27694 (See protein sequence)
Recommended Name: Replication protein A 70 kDa DNA-binding subunit  
Size: 616 amino acids; 68138 Da
Subunit: Heterotrimer composed of RPA1, RPA2 and RPA3 (canonical replication protein A complex). Component of the
alternative replication protein A complex (aRPA) composed of RPA1, RPA3 and RPA4. The DNA-binding activity may reside
exclusively on the RPA1 subunit. Interacts with RIPK1 and XPA. Interacts with RPA4. Interacts with the polymerase
alpha subunit POLA1/p180; this interaction stabilizes the replicative complex and reduces the misincorporation rate of
DNA polymerase alpha by acting as a fidelity clamp. Interacts with RAD51 and SENP6 to regulate DNA repair. Interacts
with HELB; this interaction promotes HELB recruitment to chromatin following DNA damage
Subcellular location: Nucleus
Sequence caution: Sequence=BAD92969.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
6 PDB 3D structures from and Proteopedia for RPA1:
1EWI (3D)        1FGU (3D)        1JMC (3D)        1L1O (3D)        2B29 (3D)        2B3G (3D)    
Secondary accessions: A8K0Y9 Q59ES9

Explore the universe of human proteins at neXtProt for RPA1: NX_P27694

Post-translational modifications:

  • Sumoylated on lysine residues Lys-449 and Lys-577, with Lys-449 being the major site. Sumoylation promotes recruitment
    • of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. Desumoylated by SENP61
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P27694

    • RPA1 Protein expression data from MOPED and PaxDb:    About this image 
    RPA1 Protein Expression
    REFSEQ proteins: NP_002936.1  
    ENSEMBL proteins: 
     ENSP00000461733   ENSP00000459788   ENSP00000254719   ENSP00000461466  
    Reactome Protein details: P27694
    Human Recombinant Protein Products for RPA1: 
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    Novus Biologicals RPA1 Protein
    Novus Biologicals RPA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RPA1

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000793condensed chromosome ----
    GO:0000794condensed nuclear chromosome ----
    GO:0000800lateral element IEA--
    GO:0001673male germ cell nucleus IEA--
    GO:0005634nucleus IDA--

    RPA1 for ontologies           About GeneDecksing



    RPA1 Antibody Products: 
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    Novus Biologicals RPA1 Antibodies
    Abcam antibodies for RPA1 
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    ThermoFisher Antibody for RPA1

    Assay Products for RPA1: 
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    Uscn ELISAs and CLIAs for RPA1

    Protein Domains /
    Families
    for RPA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RPA1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR012340 NA-bd_OB-fold
     IPR004365 NA-bd_OB_tRNA-helicase
     IPR013955 Rep_factor-A_C
     IPR004591 Rep_factor_Rpa1
     IPR007199 Rep_factor-A_N

    Graphical View of Domain Structure for InterPro Entry P27694

    ProtoNet protein and cluster: P27694

    3 Blocks protein families:
    IPB004365 OB-fold nucleic acid binding domain
    IPB007199 Replication factor-A protein 1
    IPB013955 Replication factor-A


    UniProtKB/Swiss-Prot: RFA1_HUMAN, P27694
    Similarity: Belongs to the replication factor A protein 1 family


    Function
    for RPA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFA1_HUMAN, P27694
    Function: Plays an essential role in several cellular processes in DNA metabolism including replication, recombination
    and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary
    DNA from reannealing
    Function: Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded
    DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle
    progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA
    polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction
    of nucleotide excision repair and RAD51-dependent strand exchange

         Genatlas biochemistry entry for RPA1:
    replication protein A,subunit 1,component 70kDa of a trimeric single strand binding protein,involved in
    replication,homologous recombination and nucleotide excision repair,colocalizing with RAD51 on synapsed axes in
    meiosis and facilitating RAD51 function,also colocalizing with BLM in meiotic prophase of prophase nuclei of
    spermatocytes

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003697single-stranded DNA binding IEA--
    GO:0005515protein binding IPI19338310
    GO:0046872metal ion binding IEA--
         
    RPA1 for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for RPA1:
     Bright nuclei  Decreased viability with cispl  Increased S DNA content, incre  Increased Salmonella enterica  
     Increased cell number in S and  Increased gamma-H2AX phosphory  Increased number of cells in m  S arrest 

         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rpa1):
     cellular  hematopoietic system  immune system  mortality/aging  tumorigenesis 

    RPA1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RPA1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPA1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate RPA1 (see all 15):
    hsa-miR-345 hsa-miR-4264 hsa-miR-361-5p hsa-miR-3616-5p hsa-miR-622 hsa-miR-3647-5p hsa-miR-3074-3p hsa-miR-151-3p
    SwitchGear 3'UTR luciferase reporter plasmid: RPA1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPA1 (see all 7)
    OriGene shRNA RFP: RPA1
    OriGene siRNA: RPA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPA1
    Sirion Biotech Custom design and validation of potent shRNA sequences against RPA1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RPA1
    Sirion Biotech Customized adenovirus for overexpression of RPA1 
    Sirion Biotech Customized adenovirus for potent knockdown of RPA1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPA1 (see all 4)
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPA1


    Pathways & Interactions
    for RPA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lagging Strand Synthesis
    8/14 pathways (see all 14)
    		Lagging Strand Synthesis1.00
    		Gap-filling DNA repair synthesis and ligation in GG-NER0.64
    		Telomere C-strand (Lagging Strand) Synthesis0.91
    		Repair synthesis of patch ~27-30 bases long by DNA polymerase0.59
    		Extension of Telomeres0.83
    		Repair synthesis for gap-filling by DNA polymerase in TC-NER0.59
    		Processive synthesis on the lagging strand0.75
    		DNA replication0.56
    2Ubiquitinated Orc1 is degraded by the proteasome
    		DNA Replication Pre-Initiation0.62
    		DNA Replication0.49
    		M/G1 Transition0.62
    		Cell Cycle Checkpoints0.42
    		Synthesis of DNA0.51
    		S Phase0.40
    3Assembly of the RAD51-ssDNA nucleoprotein complex
    		Assembly of the RAD51-ssDNA nucleoprotein complex1.00
    		Homologous DNA pairing and strand exchange0.83
    		Presynaptic phase of homologous DNA pairing and strand exchange0.83
    		Processing of DNA double-strand break ends0.60
    4Global Genomic NER (GG-NER)
    		Global Genomic NER (GG-NER)1.00
    		Dual incision reaction in GG-NER0.61
    		Nucleotide excision repair0.70
    		Formation of incision complex in GG-NER0.61
    5Formation of Meiotic Holliday Junction
    		Formation of Meiotic Holliday Junction1.00
    		Formation of Meiotic Single-stranded DNA Invasion Complex0.83
    		Formation of Meiotic Heteroduplex0.83
    		Resolution of Meiotic Holliday Junction0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RPA1
        Cell cycle Start of DNA replication in early S phase


    2 Cell Signaling Technology (CST) Pathways for RPA1
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for RPA1
        Cell cycle Start of DNA replication in early S phase

    2 BioSystems Pathways for RPA1 
        G1 to S cell cycle control
    DNA Replication

    5/47        Reactome Pathways for RPA1 (see all 47)
        Telomere Maintenance
    Activation of ATR in response to replication stress
    Processing of DNA double-strand break ends
    S Phase
    Repair synthesis of patch ~27-30 bases long by DNA polymerase


    4         Kegg Pathways  (Kegg details for RPA1):
        DNA replication
    Nucleotide excision repair
    Mismatch repair
    Homologous recombination


    RPA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/263 Interacting proteins for RPA1 (P276941, 2, 3 ENSP000002547194) via UniProtKB, MINT, STRING, and/or I2D (see all 263)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=3 
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    HIST1H4DP628053I2D: score=3 
    HIST1H4EP628053I2D: score=3 
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000216M/G1 transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--

    RPA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPA1
    10/26 Novoseek chemical compound relationships for RPA1 gene (see all 26)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rpa 2 89.1 28 17361204 (6), 19586055 (4), 15856006 (2), 8020972 (2) (see all 10)
    dbds 66 6 15047856 (2), 14596605 (1), 10473346 (1), 17583916 (1)
    cpds 54.8 1 11705987 (1)
    hydroxyurea 42.8 10 18003706 (3), 15180989 (2), 15735006 (1), 15653682 (1)
    methylmethanesulfonate 39.1 3 12697761 (1), 9539419 (1)
    oligonucleotide 35.1 9 15102447 (1), 16234232 (1), 9461638 (1), 16481746 (1) (see all 6)
    camptothecin 34.3 10 10064605 (3), 15653682 (2), 15856006 (1), 15929725 (1)
    phosphatidylinositol-3,4,5-trisphosphate 30.9 2 9052858 (1), 9427642 (1)
    danazol 30.3 3 7849064 (2), 9600915 (1)
    bpde 30.1 1 15362978 (1)

    Search CenterWatch for drugs/clinical trials and news about RPA1 / RFA1 

    Transcripts
    for RPA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPA1 gene: 
    NM_002945.3  

    Unigene Cluster for RPA1:

    Replication protein A1, 70kDa
    Hs.461925  [show with all ESTs]
    Unigene Representative Sequence: NM_002945
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000571058 ENST00000570451 ENST00000254719(uc002fto.2) ENST00000571725
    ENST00000573924 ENST00000574049 ENST00000573994

    miRNA
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    hsa-miR-345 hsa-miR-4264 hsa-miR-361-5p hsa-miR-3616-5p hsa-miR-622 hsa-miR-3647-5p hsa-miR-3074-3p hsa-miR-151-3p
    SwitchGear 3'UTR luciferase reporter plasmid: RPA1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB209732.1 AF167994.1 AK289704.1 BC018126.1 M63488.1 

    16 DOTS entries:

    DT.453758  DT.100820639  DT.436781  DT.120966270  DT.120966324  DT.407661  DT.100820638  DT.100820642 
    DT.95220953  DT.120966329  DT.92446560  DT.95146636  DT.100647566  DT.91834116  DT.95220906  DT.95238864 

    24/387 AceView cDNA sequences (see all 387):

    BM848384 BG826869 Z40763 BE898956 AA991598 BF740840 BQ218906 BM825910 
    CR615851 CR592316 AW407237 W00664 BG685852 BG029093 BM666146 BG035161 
    BQ325555 BP364363 AU122638 H04126 BM828593 BE781774 AA368874 BM848514 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RPA1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
    SP1:                                                                                      -                           
    SP2:                                                                                -     -                           
    SP3:                                                                                                                  


    ECgene alternative splicing isoforms for RPA1

    Expression
    for RPA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAGGATTT
    RPA1 Expression
    About this image

    RPA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RPA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPA1

    SOURCE GeneReport for Unigene cluster: Hs.461925
        SABiosciences Expression via Pathway-Focused PCR Arrays including RPA1: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Primer
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    Orthologs
    for RPA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPA1 gene from 10/34 species (see all 34)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rpa11 , 5 replication protein A11, 5 84.86(n)1
    86.27(a)1    		   11 (45.79 cM)5
    682751  NM_026653.21  NP_080929.11 
     752981665 
    chicken
    (Gallus gallus)    		 Aves RPA11 replication protein A1, 70kDa 74.35(n)
    75.45(a)    		   417563  NM_001006221.1  NP_001006221.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RPA16
    		 --
    		 62(a)
    		 1 ↔ 1
    		 GL343393.1(14277-46481)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3979372 replication protein A (RPA) 76.4(n)    X67240.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi14b082 wufi14b08 73.36(n)   327491  BC044372.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RpA-701 , 3 DNA dependent DNA replication
    single-stranded more3
    Replication Protein A 701    		 41(a)3
    51.2(n)1
    45.36(a)1    		   3 84F63
    409721  NM_079550.31  NP_524274.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea F18A1.53 replication factor A 31(a)   II(7664513-7666854)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RFA1(YAR007C)4
    RFA11    		 Subunit of heterotrimeric Replication Protein A (RPA), more4
    Rfa1p1    		 43.97(n)1
    32.56(a)1    		   1(158619-156754)4
    8512661, 4  NP_009404.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G191301 replication factor A1 47.36(n)
    39.86(a)    		   827651  NM_118032.2  NP_567576.2 
    rice
    (Oryza sativa)    		 Liliopsida Os05g01110001 hypothetical protein 48.39(n)
    38.75(a)    		   4337594  NM_001060980.1  NP_001054445.1 


    ENSEMBL Gene Tree for RPA1 (if available)
    TreeFam Gene Tree for RPA1 (if available) 

    Paralogs
    for RPA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for RPA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1531 NCBI SNPs in RPA1 are shown (see all 1531)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2005663081,2
    		--1731292(+) ATGCTA/GCTTTT 2 -- us2k1 ut510--------
    rs1905939001,2
    		--1731425(+) GGATCA/CCGAGG 2 -- int1 us2k10--------
    rs347912421,2
    		--1731537(+) CTACTC/TGGGAG 2 -- us2k1 int10--------
    rs1472329211,2
    		--1731555(+) CAAGAC/GAACTG 2 -- int1 us2k10--------
    rs1407291631,2
    		--1731597(+) CTGAGA/GTCACG 2 -- int1 us2k10--------
    rs80682981,2
    		C,F,A,H--1731623(+) CTGGGC/TGACAG 2 -- int1 us2k16Minor allele frequency- T:0.50NA CSA 12
    rs1828847341,2
    		--1731733(+) GTTTAC/TATGCT 2 -- us2k1 int10--------
    rs1868811761,2
    		--1731735(+) TTATAA/TGCTAA 2 -- us2k1 int10--------
    rs732991021,2
    		C--1731763(+) CTCACA/GGCAAT 2 -- us2k1 int13Minor allele frequency- G:0.20WA CSA 121
    rs2006132811,2
    		C--1731875(+) TACCAC/TCTGTG 2 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for RPA1 (1732996 - 1803376 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RPA1
         1 CNV: 7142
    Human Gene Mutation Database (HGMD): RPA1

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    Disorders / Diseases
    for RPA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RPA1 for disorders           About GeneDecksing

    OMIM gene information: 179835    OMIM disorders: --

    20/42 diseases for RPA1 (see all 42):    About MalaCards
    xeroderma pigmentosum, group a    miller-dieker syndrome    nijmegen breakage syndrome    xeroderma pigmentosum
    common variable immunodeficiency    ataxia telangiectasia    lupus erythematosus    werner syndrome
    systemic lupus erythematosus    chronic lymphocytic leukemia    multiple sclerosis    tetanus
    bloom syndrome    hepatitis c    chronic myeloid leukemia    fanconi's anemia
    lymphocytic leukemia    myeloid leukemia    encephalomyelitis    lissencephaly

    10/19 Novoseek disease relationships for RPA1 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xeroderma pigmentosum 80.3 19 8972858 (1), 10626358 (1), 10340474 (1), 10828957 (1) (see all 15)
    werner syndrome 71.2 1 15965237 (1)
    nijmegen breakage syndrome 61.5 1 18003706 (1)
    ataxia telangiectasia 49.5 2 15929725 (1)
    genetic disorder 6.08 3 8293499 (1)
    metastasis 1.89 1 17361204 (1)
    lupus erythematosus systemic 0 1 12472178 (1)
    leukemia 0 1 9279361 (1)
    necrosis 0 5 16700705 (1), 19786940 (1), 16113842 (1), 1601521 (1)
    breast cancer 0 1 15102447 (1)

    Genetic Association Database (GAD): RPA1
    Human Genome Epidemiology (HuGE) Navigator: RPA1 (10 documents)

    Export disorders for RPA1 gene to outside databases

    Publications
    for RPA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPA1 gene, integrated from 9 sources (see all 387):
    (articles sorted by number of sources associating them with RPA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a -786T-->C mutation associated with coronary spastic angina. (PubMed id 11063722)1, 4, 9 Miyamoto Y....Nakao K. (2000)
    2. Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A. (PubMed id 8454588)1, 3, 9 Umbricht C.B. and Kelly T.J. (1993)
    3. Human DNA helicase B (HDHB) binds to replication protein A and facilitates cellular recovery from replication stress. (PubMed id 22194613)1, 2 Guler G.D.... Fanning E. (2012)
    4. Sumoylation of the novel protein hRIPbeta is involved in replication protein A deposition in PML nuclear bodies. (PubMed id 16135809)1, 2 Park J.... Choe J. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA. (PubMed id 8990123)1, 2 Bochkarev A.... Frappier L. (1997)
    7. Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex. (PubMed id 7760808)1, 2 Keshav K.F.... Dutta A. (1995)
    8. Characterization of a cDNA encoding the 70-kDa single-stranded DNA- binding subunit of human replication protein A and the role of the protein in DNA replication. (PubMed id 2050703)1, 2 Erdile L.F.... Kelly T.J. (1991)
    9. Physical interaction between replication protein A (R PA) and MRN: involvement of RPA2 phosphorylation and the N-terminus of RPA1. (PubMed id 19586055)1, 9 Oakley G.G....Patrick S.M. (2009)
    10. Analysis of the human replication protein A:Rad52 complex: evidence for crosstalk between RPA32, RPA70, Rad52 and DNA. (PubMed id 12139939)1, 9 Jackson D....Borgstahl G.E. (2002)

    External Searches for RPA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RPA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6117 HGNC: 10289 AceView: RPA1 Ensembl:ENSG00000132383 euGenes: HUgn6117
    ECgene: RPA1 Kegg: 6117 H-InvDB: RPA1

    Other Databases showing RPA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RPA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPA1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rpa1/

    Intellectual Property
    for RPA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RPA1 gene:
    Search GeneIP for patents involving RPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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