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ROS1 Gene

protein-coding GIFtS: 65

GC06M117716

c-ros oncogene 1 , receptor tyrosine kinase
(Previous names: v-ros avian UR2 sarcoma virus oncogene homolog 1, v-ros UR2 sarcoma virus oncogene homolog 1 (avian) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.10.1 ^³
MCF3 ^¹, ², ⁵
OTTHUMP00000017814 ^²
OTTHUMP00000040389 ^²
ROS ^¹, ²
c-ros-1 ^¹, ², ³

Descriptions
c-ros oncogene 1 , receptor tyrosine kinase ^²
proto-oncogene c-ros-1 protein ^²
proto-oncogene tyrosine-protein kinase ROS ^²
transmembrane tyrosine-specific protein kinase ^²
v-ros UR2 sarcoma virus oncogene homolog 1 ^²
v-ros UR2 sarcoma virus oncogene homolog 1 (avian) ^¹
v-ros avian UR2 sarcoma virus oncogene homolog 1 ^¹, ²

External Ids
HGNC: 10261¹
Entrez Gene: 6098²
UniProtKB: P08922³
Ensembl: ENSG00000047936⁷

Search outside databases for aliases for ROS1 gene

Previous GC identifers: GC06M117444 GC06M117632 GC06M117655

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ROS1:

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless

subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I

integral membrane protein with tyrosine kinase activity. The protein may function as a growth or

differentiation factor receptor. [provided by RefSeq]

UniProtKB/Swiss-Prot: ROS_HUMAN, P08922

Function: This is probably a cell growth or differentiation factor receptor with a tyrosine-protein

kinase activity

Gene Wiki entry for ROS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ROS1 gene

Entrez Gene cytogenetic band: 6q22 Ensembl cytogenetic band: 6q22.2 HGNC cytogenetic band: 6q21-q22

ROS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M117716: (about GC identifiers)

Start:	117,716,223 bp from pter
End:	117,853,711 bp from pter
Size:	137,489 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ROS_HUMAN, P08922 (See protein sequence)

Recommended Name: Proto-oncogene tyrosine-protein kinase ROS precursor

Size: 2347 amino acids; 263915 Da

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: Q15368 Q5TDB5

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002935.2

ENSEMBL proteins:

ENSP00000357494 ENSP00000357493 ENSP00000384647

Human Recombinant Proteins

	Invitrogen human recombinant proteins for ROS1
	Millipore Purified and/or Recombinant ROS1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ROS)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	3785223
GO:0005890	sodium:potassium-exchanging ATPase complex	TAS	3785223
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for ROS1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for ROS1 (Ros)
	Antibodies from Abcam (ROS), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ROS1)
	Search Novus for antibodies for ROS1

Assays for ROS1:

	Invitrogen Assays for ROS1
	Millipore Kits and Assays for the Analysis of ROS1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08922

ProtoNet protein and cluster: P08922

2 Blocks protein families:

IPB002011 Receptor tyrosine kinase

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: ROS_HUMAN, P08922

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor

subfamily

Similarity: Contains 9 fibronectin type-III domains

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ROS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ROS1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002944

Applied Biosystems Silencer® siRNAs for ROS1

Sigma-Aldrich siRNA and siRNA Panels for ROS1

Sigma-Aldrich shRNA Panels and shRNA for ROS1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002944
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002944
untagged cDNA clone in CMV expression vector: NM_002944

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002944

UniProtKB/Swiss-Prot: ROS_HUMAN, P08922

Function: This is probably a cell growth or differentiation factor receptor with a tyrosine-protein

kinase activity

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1

Genatlas biochemistry entry for ROS1:

avian UR2 sarcoma virus oncogene (v-ros) homolog

1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Ros1):

reproductive system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	--
GO:0004872	receptor activity	TAS	2827175
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ROS1

5/16 Interacting proteins for ROS1 (ENSP00000357494³) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN6	ENSP00000326010³	STRING (score=.955)
TAS2R50	ENSP00000375093³	STRING (score=.943)
OR13G1	ENSP00000352717³	STRING (score=.942)
PALLD	ENSP00000261509³	STRING (score=.915)
ATP1A1	ENSP00000295598³	STRING (score=.899)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0007165	signal transduction	TAS	2827175
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ROS1
1 Novoseek chemical compound relationship for ROS1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	45.67	6	2352949 (3), 7905605 (1), 1718742 (1), 2185878 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ROS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ROS1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002944

Sigma-Aldrich siRNA and siRNA Panels for ROS1

Sigma-Aldrich shRNA Panels and shRNA for ROS1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002944

REFSEQ mRNAs for ROS1 gene:

NM_002944.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002944

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002944
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002944
                                 untagged cDNA clone in CMV expression vector: NM_002944

Additional cDNA sequence:

BC144556.1 EU236947.1 M13880.1 M34353.1

2 DOTS entries:

DT.407368 DT.304113

24/245 AceView cDNA sequences (see all 245 ):

AA731604 AA857714 BE079339 AI280205 AI674676 AA280266 AI655862 NM_020399

AA279957 AA906073 CA442919 R44525 AI970512 AA280525 AA285063 AI123743

BU619859 N79051 BM998561 AA992214 AW304241 AI089113 AI262390 AI337304

highest scoring ESTs for ROS1:

M34353 BP204713 M13880 NM_002944 W24195 W24201 AA026477 AA485969 AA487805 AI873380

Unigene Cluster for ROS1:

C-ros oncogene 1 , receptor tyrosine kinase

Hs.1041 [show with all ESTs]

Unigene Representative Sequence: M34353

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000368508 ENST00000368507 ENST00000403284

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ROS1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ROS1

¹ / ² / ³

5 probe-sets matching ROS1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
593_s_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.52	M34353	1.00	0.90	0.95	1
77023_at²^{, 3}	U95-D	1	0.81	1.00	0.55	1.61	AA913573	0.40	0.75	0.60	1
207569_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002944	0.60	0.83	0.73	1
244363_at²^{, 3}	U133-B	1	0.91	1.00	--	--	AI280391	0.40	0.75	0.60	1
207569_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ROS1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAGACAAAGA

SOURCE GeneReport for Unigene cluster: Hs.1041
Expression variation in blood from EXPOLDB for ROS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ROS1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ROS1¹	--	c-ros oncogene 1 , receptor tyrosine kinase	86.64(n) 83.68(a)	484098 XM_541215.2 XP_541215.2
chimpanzee (Pan troglodytes)	ROS1¹	--	c-ros oncogene 1 , receptor tyrosine kinase	99.43(n) 99.15(a)	472108 XM_527487.2 XP_527487.2
rat (Rattus norvegicus)	Ros1¹	--	c-ros oncogene 1 , receptor tyrosine kinase	82.71(n) 80.46(a)	25346 NM_012874.1 NP_037006.1
mouse (Mus musculus)	Ros1^{1, 5}	10 (28.00 cM)⁵	Ros1 proto-oncogene^{1, 5}	83.68(n)¹ 80.43(a)¹	19886¹ NM_011282.2¹ NP_035412.2¹ BC156297⁵ M88609⁵ (see all 8)
zebrafish (Danio rerio)	ros1²	--	v-ros UR2 sarcoma virus oncogene homolog 1 (avian)	74.41(n)	245951 AF400273.1

About this table Species with no ortholog for ROS1

ENSEMBL Gene Tree for ROS1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ROS1 gene

DDR2² DDR1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/789 NCBI SNPs in ROS1 are shown (see all 789 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 310)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2778^1,2	A,C,F,H,O	117716222(-)	`GTTCCC/TGATTT`	1	--	ng5¹		26	MN EA NS NA EU WA	3508
--	rs529156^1,2	A,C,F,H	117728881(-)	`TTTATA/CAGTCC`	1	K/Q	mis¹ ese³		9	EU EA WA NA	908
	rs619203^1,2	A,C,F,H	117728877(-)	`TAAGTC/GCAGAG`	1	S/C	mis¹ ese³		10	MN EA NA EU WA	884
	rs529038^1,2	A,C,F,H	117728926(-)	`TTCAGG/AACCAA`	1	N/D	mis¹ ese³		10	MN EU EA WA NA	1100
	rs210968^1,2	A,C,F,H	117728843(+)	`CTTTCA/CTTTAT`	1	N/K	mis¹ ese³		13	MN NA EU EA WA	1242
	rs929121^1,2	A,C,F,H	117716080(-)	`GAAACG/ACTGCT`	1	--	ng5¹		11	NA EA MN EU WA	2504
	rs1998206^1,2	A,C,F,H	117832141(-)	`CTTATA/CCTAAG`	1	T/P	mis¹ ese³		24	EU EA WA MN CSAM NA	2084
	rs12664076^1,2	C,F,H	117757225(+)	`ATTATC/GTTCAG`	1	D/H	mis¹ ese³		9	EU EA WA NA	902
	rs9489124^1,2	C,F,H	117749188(+)	`GTCTTC/TGTTTA`	1	E/K	mis¹ ese³		9	EU EA WA NA	906
	rs3752566^1,2	C,F,H	117745018(-)	`TTTGCG/ATAAAG`	1	H/R	mis¹ ese³		10	EA MN CSAM EU WA	2318

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HapMap Linkage Disequilibrium images for ROS1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 165020

UniProtKB/Swiss-Prot: ROS_HUMAN, P08922

A chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM). An

homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein which

has a constitutive receptor tyrosine kinase activity

3 Novoseek disease relationships for ROS1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
astrocytoma	59.48	5	2185878 (3), 7905605 (1)
glioblastoma	57.77	3	2185878 (2), 2352949 (1)
tumors	0.00	3	2185878 (2), 8143271 (1)

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Human Gene Mutation Database: ROS1
Genetic Association Database: ROS1
Human Genome Epidemiology Navigator: ROS1 (10 documents)
Tumor Gene Database: ROS1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/34 PubMed articles for ROS1 gene (see all 34 ):

Characterization of ROS1 cDNA from a human glioblastoma cell line. (PubMed id 2352949)^{1, 3, 4} Birchmeier C.... Wigler M. (1990)
Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). (PubMed id 12661006)^{1, 3, 4} Charest A....Housman D. (2003)
Identification of four gene variants associated with myocardial infarction. (PubMed id 16175505)^{3, 6} Shiffman D....Kane J.P. (2005)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23. (PubMed id 1611909)^{2, 3} Galland F....Birnbaum D. (1992)
Characterization of an activated human ros gene. (PubMed id 3785223)^{3, 4} Birchmeier C.... Wigler M. (1986)
Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule. (PubMed id 3023956)^{3, 4} Matsushime H.... Shibuya M. (1986)
Visualization of SHP-1-target interaction. (PubMed id 15456853)^{1, 3} Biskup C....Bohmer F.D. (2004)
Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. (PubMed id 19056482)³ Yoshida T....Yamada Y. (2009)
Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)³ Luke M.M....Psaty B.M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6098	HGNC: 10261	AceView: ROS1andGOPC	Ensembl:ENSG00000047936	euGenes: HUgn6098
ECgene: ROS1	H-InvDB: ROS1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ROS1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ROS1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ROS1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ROS1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ROS1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ROS1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ROS1 (Ros)

	Recombinant Proteins (ROS)
	Antibodies (ROS)

Search OriGene for ROS1

Search Tocris compounds for ROS1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ROS1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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ROS1 Gene at Home site.
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ROS1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for ROS1

Summaries
for ROS1

Genomic Location
for ROS1

Proteins
for ROS1

Protein Domains/
Families
for ROS1

Gene Function
for ROS1

Pathways & Interactions
for ROS1

Drugs & Compounds
for ROS1

Transcripts
for ROS1

Expression
for ROS1

Orthologs
for ROS1

Paralogs
for ROS1

SNPs/Variants
for ROS1

Disorders & Mutations
for ROS1

Medical News
for ROS1

Publications
for ROS1

Search for ROS1

Genome Databases showing ROS1

Other Databases showing ROS1

Specialized Databases showing ROS1

Licensable Technologies
for ROS1

Services
for ROS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ROS1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor ROS1

Summariesfor ROS1

Genomic Locationfor ROS1

Proteinsfor ROS1

Protein Domains/Familiesfor ROS1

Gene Functionfor ROS1

Pathways & Interactionsfor ROS1

Drugs & Compoundsfor ROS1

Transcriptsfor ROS1

Expression for ROS1

Orthologsfor ROS1

Paralogsfor ROS1

SNPs/Variantsfor ROS1

Disorders & Mutationsfor ROS1

Medical Newsfor ROS1

Publicationsfor ROS1

Search for ROS1

Genome Databases showing ROS1

Other Databases showing ROS1

Specialized Databases showing ROS1

Licensable Technologiesfor ROS1

Servicesfor ROS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ROS1

Summaries
for ROS1

Genomic Location
for ROS1

Proteins
for ROS1

Protein Domains/
Families
for ROS1

Gene Function
for ROS1

Pathways & Interactions
for ROS1

Drugs & Compounds
for ROS1

Transcripts
for ROS1

Expression
for ROS1

Orthologs
for ROS1

Paralogs
for ROS1

SNPs/Variants
for ROS1

Disorders & Mutations
for ROS1

Medical News
for ROS1

Publications
for ROS1

Licensable Technologies
for ROS1

Services
for ROS1