Aliases for ROS1 Gene
- ROS Proto-Oncogene 1, Receptor Tyrosine Kinase 2 3 5
- V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1 2 3
- C-Ros Oncogene 1 , Receptor Tyrosine Kinase 2 3
- Proto-Oncogene C-Ros-1 3 4
- MCF3 3 4
- ROS 3 4
- V-Ros UR2 Sarcoma Virus Oncogene Homolog 1 (Avian) 2
- ROS Proto-Oncogene 1 , Receptor Tyrosine Kinase 3
External Ids for ROS1 Gene
Previous GeneCards Identifiers for ROS1 Gene
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
GeneCards Summary for ROS1 Gene
ROS1 (ROS Proto-Oncogene 1, Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ROS1 include Lung Large Cell Carcinoma and Gastric Adenocarcinoma. Among its related pathways are Activation of cAMP-Dependent PKA and GPCR Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ALK.
UniProtKB/Swiss-Prot for ROS1 Gene
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.