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ROS1 Gene

protein-coding   GIFtS: 66
GCID: GC06M117609

C-Ros Oncogene 1 , Receptor Tyrosine Kinase

(Previous names: v-ros avian UR2 sarcoma virus oncogene homolog 1, v-ros...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
C-Ros Oncogene 1 , Receptor Tyrosine Kinase1 2     Proto-Oncogene Tyrosine-Protein Kinase ROS2
MCF32 3 5     Transmembrane Tyrosine-Specific Protein Kinase2
V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 11 2     EC 2.7.10.13
Proto-Oncogene C-Ros-12 3     C-Ros Receptor Tyrosine Kinase3
ROS2 3     Proto-Oncogene C-Ros3
V-Ros UR2 Sarcoma Virus Oncogene Homolog 1 (Avian)1     Receptor Tyrosine Kinase C-Ros Oncogene 13
c-ros-12     

External Ids:    HGNC: 102611   Entrez Gene: 60982   Ensembl: ENSG000000479367   OMIM: 1650205   UniProtKB: P089223   

Export aliases for ROS1 gene to outside databases

Previous GC identifers: GC06M117444 GC06M117632 GC06M117655 GC06M117716 GC06M115190


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ROS1 Gene:
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of
tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein
with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. (provided
by RefSeq, Jul 2008)

GeneCards Summary for ROS1 Gene:
ROS1 (c-ros oncogene 1 , receptor tyrosine kinase) is a protein-coding gene. GO annotations related to this gene include transmembrane receptor protein tyrosine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is ROR1.

UniProtKB/Swiss-Prot: ROS1_HUMAN, P08922
Function: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and
regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related
to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway.
Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the
transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the
activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other
downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2

Gene Wiki entry for ROS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ROS1 gene promoter:
         p53   AP-1   ATF-2   Nkx2-5   HNF-1A   CREB   deltaCREB   HNF-1   c-Jun   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ROS1 promoter sequence
   Search Chromatin IP Primers for ROS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ROS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q21-q22

ROS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ROS1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M117609:  view genomic region     (about GC identifiers)

Start:
117,609,463 bp from pter      End:
117,747,018 bp from pter
Size:
137,556 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ROS1_HUMAN, P08922 (See protein sequence)
Recommended Name: Proto-oncogene tyrosine-protein kinase ROS precursor  
Size: 2347 amino acids; 263915 Da
Subunit: Interacts with PTPN6 (via SH2 1 domain); the interaction is direct and promotes ROS1 dephosphorylation
(By similarity). Interacts with PTPN11; may activate the PI3 kinase-mTOR signaling pathway. Interacts with VAV3;
constitutive interaction mediating VAV3 phosphorylation
1 PDB 3D structure from and Proteopedia for ROS1:
3ZBF (3D)    
Secondary accessions: Q15368 Q5TDB5

Explore the universe of human proteins at neXtProt for ROS1: NX_P08922

Explore proteomics data for ROS1 at MOPED

Post-translational modifications: 

  • Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2274 is required for the interaction with
    PTPN6 that mediates ROS1 dephosphorylation (By similarity). Phosphorylation at Tyr-2274 stimulates the kinase
    activity and the activation of the ERK1 signaling cascade (By similarity). Phosphorylation at Tyr-2274 and/or
    Tyr-2334 recruits PTPN111
  • Glycosylation2 at Asn52, Asn114, Asn123, Asn324, Asn352, Asn396, Asn471, Asn607, Asn628, Asn706,
                                 Asn714, Asn732, Asn939, Asn961, Asn1015, Asn1087, Asn1090, Asn1095, Asn1211, Asn1272 (see all 30)
  • Modification sites at PhosphoSitePlus

  • See ROS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002935.2  
    ENSEMBL proteins: 
     ENSP00000357494   ENSP00000357493   ENSP00000384647  

    ROS1 Human Recombinant Protein Products:

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    antibodies-online peptides for ROS1

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    antibodies-online antibodies for ROS1 (15 products) 

    ROS1 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ROS1
    Cloud-Clone Corp. CLIAs for ROS1
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    antibodies-online kits for ROS1 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: c-ros oncogene 1, receptor tyrosine kinase
    Sev family
    Leukocyte tyrosine kinase (LTK) receptor family

    Selected InterPro protein domains (see all 11):
     IPR000033 LDLR_classB_rpt
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011042 6-blade_b-propeller_TolB-like

    Graphical View of Domain Structure for InterPro Entry P08922

    ProtoNet protein and cluster: P08922

    2 Blocks protein domains:
    IPB002011 Receptor tyrosine kinase
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: ROS1_HUMAN, P08922
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 9 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with ROS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ROS1_HUMAN, P08922
    Function: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and
    regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related
    to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway.
    Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the
    transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the
    activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other
    downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Inhibited by dephosphorylation by PTPN6 (By similarity)

         Genatlas biochemistry entry for ROS1:
    avian UR2 sarcoma virus oncogene (v-ros) homolog

         Enzyme Number (IUBMB): EC 2.7.10.11

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity IDA16885344
    GO:0004714transmembrane receptor protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI17416557
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with ROS1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for ROS1:
     Decreased substrate adherent c  Increased colony dispersion (i  Increased viability with TRAIL  Upregulation of Wnt/beta-caten 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Ros1):
     reproductive system 

    Find genes that share phenotypes with ROS1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ROS1: Ros1tm2Cbm Ros1tm1Cbm

       genOway: Develop your customized and physiologically relevant rodent model for ROS1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ROS1_HUMAN, P08922: Cell membrane; Single-pass type I membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane TAS3785223
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ROS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ROS1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71


    Find genes that share SuperPaths with ROS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ROS1 (see all 28)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for ROS1
        Tyrosine Kinases / Adaptors


        Pathway & Disease-focused RT2 Profiler PCR Array including ROS1: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ROS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ROS1 (P089221, 2, 3 ENSP000003574944) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293501, 2, 3, ENSP000003915924EBI-7371065,EBI-78260 MINT-6799844 MINT-8034659 MINT-8034674 MINT-6799829 I2D: score=3 STRING: ENSP00000391592
    PTPN1P180311, 2, 3, ENSP000003606834EBI-7371065,EBI-968788 MINT-6799784 MINT-6799799 MINT-6799814 I2D: score=1 STRING: ENSP00000360683
    GRB2P629933, ENSP000003390074I2D: score=3 STRING: ENSP00000339007
    LPHN1O949103, ENSP000003406884I2D: score=2 STRING: ENSP00000340688
    VAV3Q9UKW43, ENSP000003590734I2D: score=2 STRING: ENSP00000359073
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002066columnar/cuboidal epithelial cell development ISS--
    GO:0006468protein phosphorylation IDA16885344
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--
    GO:0007283spermatogenesis ISS--
    GO:0008283cell proliferation ISS--

    Find genes that share ontologies with ROS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ROS1

    2 HMDB Compounds for ROS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 Novoseek inferred chemical compound relationship for ROS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 44.9 6 2352949 (3), 7905605 (1), 1718742 (1), 2185878 (1)



    Find genes that share compounds with ROS1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ROS1 gene: 
    NM_002944.2  

    Unigene Cluster for ROS1:

    C-ros oncogene 1 , receptor tyrosine kinase
    Hs.1041  [show with all ESTs]
    Unigene Representative Sequence: M34353
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368508(uc003pxp.1 uc011ebi.1) ENST00000368507 ENST00000403284

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    Additional mRNA sequence: 

    AB698667.1 AB795239.1 AB795240.1 AB795241.1 AB795242.1 AB795244.1 AB795245.1 AB795246.1 
    BC144556.1 M13880.1 M34353.1 

    2 DOTS entries:

    DT.407368  DT.304113 

    Selected AceView cDNA sequences (see all 245):

    AA701453 AW084342 AI337304 BG150330 AA285063 CA442919 AI280205 BC009553 
    AW304241 AA992214 AI674993 BE079339 AA731604 AA280525 N32368 BU619859 
    AA939322 AA459108 AW015608 NM_002944 AI123743 AA290953 N79051 AA279957 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ROS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGACAAAGA
    ROS1 Expression
    About this image

    ROS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ROS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1041

    UniProtKB/Swiss-Prot: ROS1_HUMAN, P08922
    Tissue specificity: Expressed in brain. Expression is increased in primary gliomas

        Pathway & Disease-focused RT2 Profiler PCR Array including ROS1: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ROS1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ros11 , 5 Ros1 proto-oncogene1, 5 83.68(n)1
    80.43(a)1
      10 (26.18 cM)5
    198861  NM_011282.21  NP_035412.21 
     520457215 
    chicken
    (Gallus gallus)
    Aves ROS11 c-ros oncogene 1 , receptor tyrosine kinase 62.99(n)
    55.13(a)
      396192  NM_205257.2  NP_990588.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    23(a)
    many ↔ many
    GL344332.1(9724-33157)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ros11 c-ros oncogene 1 , receptor tyrosine kinase 56.83(n)
    47.41(a)
      101733913  XM_004914866.1  XP_004914923.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ros12 v-ros UR2 sarcoma virus oncogene homolog 1 (avian) 74.41(n)   245951  AF400273.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sev1 , 3 R7 cell fate commitment protein
    tyrosine kinase3
    sevenless1
    39(a)3
    41.53(n)1
    32.15(a)1
      1 10A43
    320391  NM_078559.21  NP_511114.21 
    worm
    (Caenorhabditis elegans)
    Secernentea R151.43 Tyrosine kinase 37(a)
    (best of 3)
      III(7291720-7292812)   --


    ENSEMBL Gene Tree for ROS1 (if available)
    TreeFam Gene Tree for ROS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ROS1 gene
    ROR12  INSR2  NTRK22  LTK2  IGF1R2  DDR12  NTRK32  INSRR2  
    ROR22  DDR22  MUSK2  ALK2  NTRK12  
    Selected SIMAP similar genes for ROS1 using alignment to 3 protein entries:     ROS1_HUMAN (see all proteins) (see all similar genes):
    CD74/ROS fusion    EZR-ROS1    SLC34A2/ROS fusion    R34    TPM3-ROS1    LRIG3(NM_001136051)-ROS1
    LRIG3(NM_153377)-ROS1    SLC34A2/ROS1 fusion    SLC34A2-ROS1    R32    FGR    SRC
    ABL1    DKFZp434L0319    FYN    tec    FNDC3B    FRK

    Find genes that share paralogs with ROS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ROS1 (see all 3066)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0414564
    A colorectal adenocarcinoma sample4--see VAR_0414562 K R mis40--------
    VAR_0414574
    A gastric adenocarcinoma sample4--see VAR_0414572 F S mis40--------
    VAR_0414504
    A lung large cell carcinoma sample4--see VAR_0414502 Q H mis40--------
    VAR_0414474
    A gastric adenocarcinoma sample4--see VAR_0414472 Y H mis40--------
    rs30867541,2
    C--117609081(+) GTCTC-/A/AAA 
            
    AAAAA
    2 -- ds5001 cds11NA 2
    rs1851658091,2
    --117609096(+) AAAAAA/TAATTA 1 -- ds50010--------
    rs1899437091,2
    --117609155(+) TCTCAA/GGTCAC 1 -- ds50010--------
    rs1825324771,2
    --117609272(+) TCTTTA/GTATCG 1 -- ds50010--------
    rs1873557691,2
    --117609343(+) TGAAAG/TGTGGG 1 -- ds50010--------
    rs9291211,2
    C,F,A,H--117609387(-) GAAACG/ACTGCT 1 -- ds500130Minor allele frequency- A:0.46NA EA MN NS WA CSA 4448

    HapMap Linkage Disequilibrium report for ROS1 (117609463 - 117747018 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ROS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2635247CNV Deletion19546169
    esv267426CNV Insertion20981092
    nsv526934CNV Loss19592680
    nsv510048CNV Loss20534489
    nsv830785CNV Gain17160897
    dgv2004e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ROS1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ROS1
    DNA2.0 Custom Variant and Variant Library Synthesis for ROS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 165020    OMIM disorders: --

    UniProtKB/Swiss-Prot: ROS1_HUMAN, P08922
  • Note=A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An
    intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which is
    localized to the Golgi and has a constitutive receptor tyrosine kinase activity. A SLC34A2-ROS1 chimeric protein
    produced in non-small cell lung cancer cells also retains a constitutive kinase activity. A third type of
    chimeric protein CD74-ROS1 was also identified in those cells

  • 2 diseases from the University of Copenhagen DISEASES database for ROS1:
    Renal oncocytoma     Lung cancer

    Find genes that share disorders with ROS1           About GenesLikeMe

    3 Novoseek inferred disease relationships for ROS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 58.9 5 2185878 (3), 7905605 (1)
    glioblastoma 56.4 3 2185878 (2), 2352949 (1)
    tumors 0 3 2185878 (2), 8143271 (1)

    Genetic Association Database (GAD): ROS1
    Human Genome Epidemiology (HuGE) Navigator: ROS1 (20 documents)
    Tumor Gene Database (TGDB): ROS1

    Export disorders for ROS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ROS1 gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with ROS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of ROS1 cDNA from a human glioblastoma cell line. (PubMed id 2352949)1, 2, 9 Birchmeier C.... Wigler M. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    2. Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). (PubMed id 12661006)1, 2, 9 Charest A....Housman D. (Genes Chromosomes Cancer 2003)
    3. Variations of specific non-candidate genes and risk of myocardial infarction: a replication study. (PubMed id 19709766)1, 4 Koch W....Kastrati A. (Int. J. Cardiol. 2011)
    4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    7. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    8. Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)
    9. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. (PubMed id 19056482)1, 4 Yoshida T....Yamada Y. (Genomics 2009)
    10. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6098 HGNC: 10261 AceView: ROS1andGOPC Ensembl:ENSG00000047936 euGenes: HUgn6098
    ECgene: ROS1 H-InvDB: ROS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ROS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ROS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ROS1 gene:
    Search GeneIP for patents involving ROS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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