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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ROS1 Gene

protein-coding   GIFtS: 65
GCID: GC06M117609

c-ros oncogene 1 , receptor tyrosine kinase

(Previous names: v-ros avian UR2 sarcoma virus oncogene homolog 1, v-ros...)
 Explore 16 diseases affiliated with
ROS1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ROS1    

Aliases
for ROS1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
C-Ros Oncogene 1 , Receptor Tyrosine Kinase1 2     Receptor Tyrosine Kinase C-Ros Oncogene 12 3
MCF31 2 3 5     C-Ros Receptor Tyrosine Kinase2 3
ROS1 2 3     V-Ros UR2 Sarcoma Virus Oncogene Homolog 1 (Avian)1
C-Ros-11     Proto-Oncogene Tyrosine-Protein Kinase ROS2
V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 11 2     Transmembrane Tyrosine-Specific Protein Kinase2
Proto-Oncogene C-Ros2 3     V-Ros UR2 Sarcoma Virus Oncogene Homolog 12
Proto-Oncogene C-Ros-12 3     EC 2.7.10.13

External Ids:    HGNC: 102611   Entrez Gene: 60982   Ensembl: ENSG000000479367   OMIM: 1650205   UniProtKB: P089223   

Export aliases for ROS1 gene to outside databases

Previous GC identifers: GC06M117444 GC06M117632 GC06M117655 GC06M117716 GC06M115190


Summaries
for ROS1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ROS1:
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine
kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine
kinase activity. The protein may function as a growth or differentiation factor receptor. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: ROS1_HUMAN, P08922
Function: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and
regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to
cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the
phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor
STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine
nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including
AKT1, MAPK1, MAPK3, IRS1 and PLCG2

Gene Wiki entry for ROS1


Genomic Views
for ROS1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ROS1 gene promoter:
         p53   AP-1   ATF-2   Nkx2-5   HNF-1A   CREB   deltaCREB   HNF-1   c-Jun   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ROS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ROS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ROS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q21-q22

ROS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ROS1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M117609:  view genomic region     (about GC identifiers)

Start:
 117,609,463 bp from pter      End:
 117,747,018 bp from pter
Size:
 137,556 bases      Orientation:
 minus strand

Proteins
for ROS1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ROS1_HUMAN, P08922 (See protein sequence)
Recommended Name: Proto-oncogene tyrosine-protein kinase ROS precursor  
Size: 2347 amino acids; 263915 Da
Subunit: Interacts with PTPN6 (via SH2 1 domain); the interaction is direct and promotes ROS1 dephosphorylation (By
similarity). Interacts with PTPN11; may activate the PI3 kinase-mTOR signaling pathway. Interacts with VAV3;
constitutive interaction mediating VAV3 phosphorylation
Subcellular location: Cell membrane; Single-pass type I membrane protein (Probable)
Secondary accessions: Q15368 Q5TDB5

Explore the universe of human proteins at neXtProt for ROS1: NX_P08922

Post-translational modifications:

  • Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2274 is required for the interaction with PTPN6
    • that mediates ROS1 dephosphorylation (By similarity). Phosphorylation at Tyr-2274 stimulates the kinase activity and
    the activation of the ERK1 signaling cascade (By similarity). Phosphorylation at Tyr-2274 and/or Tyr-2334 recruits
    PTPN111
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08922

    • ROS1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002935.2  
    ENSEMBL proteins: 
     ENSP00000357494   ENSP00000357493   ENSP00000384647  

    Human Recombinant Protein Products: 
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    Uscn Proteins for ROS1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane IEA--
    GO:0016020membrane TAS3785223
    GO:0016021integral to membrane IEA--


    ROS1 for ontologies           About GeneDecksing



    ROS1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ROS1
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    Novus Biologicals ROS1 Antibody
    Abcam antibodies for ROS1 
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    ThermoFisher Antibodies for ROS1

    Assay Products for ROS1: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript ROS1-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for ROS1 (ROS)
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ROS1

    Protein Domains /
    Families
    for ROS1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ROS1 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR000033 LDLR_classB_rpt
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011042 6-blade_b-propeller_TolB-like

    Graphical View of Domain Structure for InterPro Entry P08922

    ProtoNet protein and cluster: P08922

    2 Blocks protein families:
    IPB002011 Receptor tyrosine kinase
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: ROS1_HUMAN, P08922
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 9 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain


    Function
    for ROS1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ROS1_HUMAN, P08922
    Function: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and
    regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to
    cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the
    phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor
    STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine
    nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including
    AKT1, MAPK1, MAPK3, IRS1 and PLCG2
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Inhibited by dephosphorylation by PTPN6 (By similarity)

         Genatlas biochemistry entry for ROS1:
    avian UR2 sarcoma virus oncogene (v-ros) homolog

    Enzyme Number (IUBMB): EC 2.7.10.11

    miRNA
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    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ROS1 (see all 7)
    OriGene shRNA RFP: ROS1
    OriGene siRNA: ROS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ROS1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ROS1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ROS1 (see all 4)
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    Cell Line
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    Search LifeMap BioReagents cell lines for ROS1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROS1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004713protein tyrosine kinase activity IDA16885344
    GO:0004714transmembrane receptor protein tyrosine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0019903protein phosphatase binding IPI16885344


    ROS1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for ROS1:
     Decreased substrate adherent c  Increased colony dispersion (i  Increased viability with TRAIL  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for ROS1: Ros1tm2Cbm Ros1tm1Cbm
         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Ros1):
     reproductive system 

    ROS1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ROS1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		CDC42 Pathway0.34
    		Actin Nucleation and Branching0.66
    5Akt Signaling
    		Akt Signaling1.00
    		p38 Signaling0.60

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ROS1 (see all 28)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for ROS1
        Tyrosine Kinases / Adaptors



    ROS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ROS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/45 Interacting proteins for ROS1 (P089222, 3 ENSP000003574944) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293502, 3, ENSP000003915924MINT-6799844 MINT-8034659 MINT-8034674 MINT-6799829 I2D: score=3 STRING: ENSP00000391592
    PTPN1P180312, 3, ENSP000003606834MINT-6799784 MINT-6799799 MINT-6799814 I2D: score=1 STRING: ENSP00000360683
    LPHN1O949103, ENSP000003406884I2D: score=2 STRING: ENSP00000340688
    PTPN11Q061243, ENSP000003409444I2D: score=2 STRING: ENSP00000340944
    VAV3Q9UKW43, ENSP000003590734I2D: score=2 STRING: ENSP00000359073
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002066columnar/cuboidal epithelial cell development ISS--
    GO:0006468protein phosphorylation IDA16885344
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--
    GO:0007283spermatogenesis ISS--
    GO:0008283cell proliferation ISS--


    ROS1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ROS1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ROS1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ROS1

    2 HMDB Compounds for ROS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    1 Novoseek chemical compound relationship for ROS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 44.9 6 2352949 (3), 7905605 (1), 1718742 (1), 2185878 (1)

    Search CenterWatch for drugs/clinical trials and news about ROS1 

    Transcripts
    for ROS1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ROS1 gene: 
    NM_002944.2  

    Unigene Cluster for ROS1:

    C-ros oncogene 1 , receptor tyrosine kinase
    Hs.1041  [show with all ESTs]
    Unigene Representative Sequence: M34353
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368508(uc003pxp.1 uc011ebi.1) ENST00000368507 ENST00000403284


    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: ROS1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ROS1
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB698667.1 BC144556.1 M13880.1 M34353.1 

    2 DOTS entries:

    DT.407368  DT.304113 

    24/245 AceView cDNA sequences (see all 245):

    AW084342 BC009553 AA731604 NM_002944 AA280525 AA285063 BG150330 AI337304 
    AA290953 AA701453 AI280205 BE079339 N32368 AA857714 BG259780 AA394059 
    AI339493 AF450008 Z43597 Z39661 AW438833 AI970512 CA398149 W24201 

    GeneLoc Exon Structure


    Expression
    for ROS1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ROS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGACAAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ROS1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    KidneyUreteric BudKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See ROS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ROS1

    SOURCE GeneReport for Unigene cluster: Hs.1041

    UniProtKB/Swiss-Prot: ROS1_HUMAN, P08922
    Tissue specificity: Expressed in brain. Expression is increased in primary gliomas

        SABiosciences Expression via Pathway-Focused PCR Array including ROS1: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROS1

    Orthologs
    for ROS1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ROS1 gene from 3/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ROS11 c-ros oncogene 1 , receptor tyrosine kinase 62.87(n)
    55.02(a)    		   396192  NM_205257.2  NP_990588.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii ros12 v-ros UR2 sarcoma virus oncogene homolog 1 (avian) 74.41(n)   245951  AF400273.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sev1 , 3 R7 cell fate commitment protein tyrosine
    kinase3
    sevenless1    		 39(a)3
    41.48(n)1
    31.85(a)1    		   1 10A43
    320391  NM_078559.21  NP_511114.21 


    ENSEMBL Gene Tree for ROS1 (if available)
    TreeFam Gene Tree for ROS1 (if available) 

    Paralogs
    for ROS1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ROS1 gene
    INSR2  ROR12  NTRK22  LTK2  IGF1R2  DDR12  NTRK32  ROR22  
    INSRR2  DDR22  MUSK2  ALK2  NTRK12  
    18/23 SIMAP similar genes for ROS1 using alignment to 3 protein entries:     ROS1_HUMAN (see all proteins) (see all similar genes):
    CD74/ROS fusion    EZR-ROS1    SLC34A2/ROS fusion    SLC34A2/ROS1 fusion    FGR    SRC
    ABL1    DKFZp434L0319    FYN    tec    FNDC3B    FRK
    EPHA2    KIT    urf-ret    FNDC3A    PTK6    RYK

    ROS1 for paralogs           About GeneDecksing



    Genomic Variants
    for ROS1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2523 NCBI SNPs in ROS1 are shown (see all 2523)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs769909261,2
    		C,--115306065(+) AATCAA/GTCAGT 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs339937461,2
    		C--117609081(+) GTCTC-/AAAAAAAA 1 -- ds50010--------
    rs1851658091,2
    		--117609096(+) AAAAAA/TAATTA 1 -- ds50010--------
    rs1899437091,2
    		--117609155(+) TCTCAA/GGTCAC 1 -- ds50010--------
    rs1825324771,2
    		--117609272(+) TCTTTA/GTATCG 1 -- ds50010--------
    rs1873557691,2
    		--117609343(+) TGAAAG/TGTGGG 1 -- ds50010--------
    rs9291211,2
    		C,F,A,H,--117609387(-) GAAACG/ACTGCT 1 -- ds500130Minor allele frequency- A:0.46NA EA MN NS WA CSA 4448
    rs1424931151,2
    		--117609397(+) CCCTTC/TCAGAC 1 -- ds50010--------
    rs1120101441,2
    		--117609399(+) CTTCCG/AGACTT 1 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs1379809521,2
    		--117609407(+) CTTCTA/GAGTCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ROS1 (117609463 - 117747018 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ROS1
         2 CNVs: 99678 3635
    Human Gene Mutation Database (HGMD): ROS1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ROS1
    DNA2.0 Custom Variant and Variant Library Synthesis for ROS1

    Disorders / Diseases
    for ROS1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ROS1 for disorders           About GeneDecksing

    OMIM gene information: 165020    OMIM disorders: --

    UniProtKB/Swiss-Prot: ROS1_HUMAN, P08922
  • Note=A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An
    • intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which is
    localized to the Golgi and has a constitutive receptor tyrosine kinase activity. A SLC34A2-ROS1 chimeric protein
    produced in non-small cell lung cancer cells also retains a constitutive kinase activity. A third type of chimeric
    protein CD74-ROS1 was also identified in those cells

    16 diseases for ROS1:    About MalaCards
    sarcoma    renal oncocytoma    myocardial infarction    cerebral infarction
    epididymitis    astrocytoma    kidney disease    glioblastoma
    pulmonary disease    cerebritis    meningioma    cholangiocarcinoma
    hypertension    breast cancer    adenocarcinoma    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for ROS1:
    Renal oncocytoma

    3 Novoseek disease relationships for ROS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 58.9 5 2185878 (3), 7905605 (1)
    glioblastoma 56.4 3 2185878 (2), 2352949 (1)
    tumors 0 3 2185878 (2), 8143271 (1)

    Genetic Association Database (GAD): ROS1
    Human Genome Epidemiology (HuGE) Navigator: ROS1 (20 documents)
    Tumor Gene Database (TGDB): ROS1

    Export disorders for ROS1 gene to outside databases

    Publications
    for ROS1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ROS1 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with ROS1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of ROS1 cDNA from a human glioblastoma cell line. (PubMed id 2352949)1, 2, 9 Birchmeier C.... Wigler M. (1990)
    2. Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). (PubMed id 12661006)1, 2, 9 Charest A....Housman D. (2003)
    3. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107)1, 2 Rikova K....Comb M.J. (2007)
    4. ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. (PubMed id 16885344)1, 2 Charest A....Housman D. (2006)
    5. Identification of four gene variants associated with myocardial infarction. (PubMed id 16175505)1, 4 Shiffman D.... Kane J.P. (2005)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma. (PubMed id 12538861)1, 2 Charest A....Housman D. (2003)
    8. Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation. (PubMed id 11094073)1, 2 Zeng L....Wang L.H. (2000)
    9. Localization of the 5' end of the MCF2 oncogene to hu man chromosome 15q15----q23. (PubMed id 1611909)1, 3 Galland F....Birnbaum D. (1992)
    10. Characterization of an activated human ros gene. (PubMed id 3785223)1, 2 Birchmeier C.... Wigler M. (1986)

    External Searches for ROS1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ROS1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6098 HGNC: 10261 AceView: ROS1andGOPC Ensembl:ENSG00000047936 euGenes: HUgn6098
    ECgene: ROS1 H-InvDB: ROS1

    Other Databases showing ROS1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ROS1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ROS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ROS1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ROS1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ROS1 gene:
    Search GeneIP for patents involving ROS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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