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RORC Gene

protein-coding   GIFtS: 65
GCID: GC01M151778

RAR-Related Orphan Receptor C

  See RORC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAR-Related Orphan Receptor C1 2     TOR2
RORG2 3 5     Nuclear Receptor ROR-Gamma2
RZRG2 3 5     RAR-Related Orphan Nuclear Receptor Variant 22
Nuclear Receptor RZR-Gamma2 3     Retinoic Acid-Binding Receptor Gamma2
Nuclear Receptor Subfamily 1 Group F Member 32 3     Retinoid-Related Orphan Receptor Gamma2
NR1F32 3     Retinoid-Related Orphan Receptor-Gamma3
RZR-GAMMA2     

External Ids:    HGNC: 102601   Entrez Gene: 60972   Ensembl: ENSG000001433657   OMIM: 6029435   UniProtKB: P514493   

Export aliases for RORC gene to outside databases

Previous GC identifers: GC01M149620 GC01M147561 GC01M148553 GC01M148995 GC01M148997 GC01M148592 GC01M150040 GC01M150046 GC01M123155


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RORC Gene:
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of
nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar
gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important
regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may
inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RORC Gene:
RORC (RAR-related orphan receptor C) is a protein-coding gene. Diseases associated with RORC include red color blindness, and color blindness. GO annotations related to this gene include ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is VDR.

UniProtKB/Swiss-Prot: RORG_HUMAN, P51449
Function: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators
recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including
lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the
expression of several components of the circadian clock

Gene Wiki entry for RORC (RAR-related orphan receptor gamma) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RORC gene promoter:
         AP-1   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RORC promoter sequence
   Search Chromatin IP Primers for RORC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RORC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

RORC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RORC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M151778:  view genomic region     (about GC identifiers)

Start:
151,778,547 bp from pter      End:
151,804,348 bp from pter
Size:
25,802 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RORG_HUMAN, P51449 (See protein sequence)
Recommended Name: Nuclear receptor ROR-gamma  
Size: 518 amino acids; 58195 Da
Sequence caution: Sequence=AAA64751.1; Type=Frameshift; Positions=516;
6 PDB 3D structures from and Proteopedia for RORC:
3B0W (3D)        3KYT (3D)        3L0J (3D)        3L0L (3D)        4NB6 (3D)        4NIE (3D)    
Secondary accessions: Q5SZR9 Q8N5V7 Q8NCY8
Alternative splicing: 2 isoforms:  P51449-1   P51449-2   

Explore the universe of human proteins at neXtProt for RORC: NX_P51449

Explore proteomics data for RORC at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys279
  • Modification sites at PhosphoSitePlus

  • See RORC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001001523.1  NP_005051.2  

    ENSEMBL proteins: 
     ENSP00000349164   ENSP00000327025   ENSP00000376461  
    Reactome Protein details: P51449

    RORC Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RORC
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for RORC (9 products) 

     
    antibodies-online peptides for RORC

    RORC Antibody Products:

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    antibodies-online antibodies for RORC (116 products) 

    RORC Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    antibodies-online kits for RORC (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: RAR-related orphan receptor-gamma
    1F. RAR-related orphan receptors

    Selected InterPro protein domains (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR001723 Str_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry P51449

    ProtoNet protein and cluster: P51449

    2 Blocks protein domains:
    IPB001723 Steroid hormone receptor signature
    IPB003079 Nuclear receptor ROR family (1F nuclear receptor) signature


    UniProtKB/Swiss-Prot: RORG_HUMAN, P51449
    Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Find genes that share domains with RORC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RORG_HUMAN, P51449
    Function: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators
    recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including
    lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the
    expression of several components of the circadian clock

         Genatlas biochemistry entry for RORC:
    RAR related orphan receptor,ligand activated transcription factor,highly expressed in skeletal
    muscle,steroid/thyroid retinoic receptor superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity ISS--
    GO:0003707steroid hormone receptor activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with RORC           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RORC:
     Increased cell number in G1, a 

         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Rorc):
     cellular  digestive/alimentary  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with RORC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RORC: Rorctm1Litt Rorctm1Amj

       genOway: Develop your customized and physiologically relevant rodent model for RORC

    miRNA
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    miRTarBase miRNAs that target RORC:
    hsa-mir-26b-5p (MIRT030126), hsa-mir-335-5p (MIRT018972), hsa-mir-30b-3p (MIRT007283), hsa-mir-148b-3p (MIRT019468)

    Block miRNA regulation of human, mouse, rat RORC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RORC (see all 38):
    hsa-miR-607 hsa-let-7d hsa-miR-106a hsa-miR-519a hsa-miR-3921 hsa-miR-10b* hsa-miR-4314 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidRORC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RORC

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): RORC (NM_005060)
    Sino Biological Human cDNA Clone for RORC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RORC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RORC

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RORC

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA6-10768) for RORC 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RORG_HUMAN, P51449: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with RORC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RORC About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2Cytokine production by Th17 cells in CF
    Cytokine production by Th17 cells in CF0.72
    Cytokine production by Th17 cells in CF Mouse model 0.72
    3Th17 Differentiation
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47
    Th17 Differentiation0.47
    4Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    5Sweet Taste Signaling
    Melatonin Signaling0.72


    Find genes that share SuperPaths with RORC           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for RORC
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th17 Differentiation

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RORC
        Melatonin Signaling

    4 GeneGo (Thomson Reuters) Pathways for RORC
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF
    Mucin expression in CF via IL-6, IL-17 signaling pathways
    Immune response IL-23 signaling pathway

    1 BioSystems Pathway for RORC
        Nuclear Receptors


    1 Reactome Pathway for RORC
        Nuclear Receptor transcription pathway


    2 Kegg Pathways  (Kegg details for RORC):
        Circadian rhythm
    Inflammatory bowel disease (IBD)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RORC: 
              Innate & Adaptive Immune Responses in human mouse rat
              Th17 Response in human mouse rat
              Circadian Rhythms in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RORC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RORC (P514491, 3 ENSP000003270254) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF4EBP1Q135413, ENSP000003406914I2D: score=1 STRING: ENSP00000340691
    CHD4Q148393, ENSP000003495084I2D: score=1 STRING: ENSP00000349508
    NCOA6Q146863I2D: score=3 
    EIF3IQ133473I2D: score=1 
    EWSR1Q018443I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006468protein phosphorylation IEA--
    GO:0006805xenobiotic metabolic process ISS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with RORC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RORC (RORG)

    3 IUPHAR Ligands for RORC (RAR-related orphan receptor-gamma)    About this table
    LigandTypeActionAffinityPubmed IDs
    25-hydroxycholesterol
    AgonistAgonist20203100
    ALRT 1550
    AntagonistAntagonist12958591
    all-trans-retinoic acid
    AntagonistAntagonist12958591



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RORC gene (2 alternative transcripts): 
    NM_001001523.1  NM_005060.3  

    Unigene Cluster for RORC:

    RAR-related orphan receptor C
    Hs.256022  [show with all ESTs]
    Unigene Representative Sequence: NM_005060
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356728(uc001ezg.3 uc001ezh.3 uc010pdo.2 uc010pdp.2)
    ENST00000318247 ENST00000480719 ENST00000392697
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    Selected qRT-PCR Assays for microRNAs that regulate RORC (see all 38):
    hsa-miR-607 hsa-let-7d hsa-miR-106a hsa-miR-519a hsa-miR-3921 hsa-miR-10b* hsa-miR-4314 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidRORC 3' UTR sequence
    Inhib. RNA
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      Search QuantiFast Probe-based Assays in human, mouse, rat RORC
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    Additional mRNA sequence: 

    AB307696.1 AF075096.1 AK097994.1 AK223137.1 AK298460.1 AK315662.1 AL834219.1 BC031554.1 
    BC110571.2 CR457436.1 HQ692834.1 U16997.1 

    4 DOTS entries:

    DT.211192  DT.102842425  DT.101976876  DT.121326057 

    Selected AceView cDNA sequences (see all 71):

    BC031554 BX091308 AK097994 NM_001001523 BM856735 BQ447902 BP368095 AK128522 
    BI256620 CD619720 AA286679 BM967010 CR457436 NM_005060 BU526834 BM967033 
    H59326 AL834219 CB150444 BP368501 U16997 AI793254 AA179004 AV684491 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RORC (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
    SP1:        -     -     -                 -                 -           -                                             
    SP2:                    -                 -                 -           -                                             
    SP3:                                                        -                                                         
    SP4:                                                                                                                  
    SP5:                    -                                                                                             


    ECgene alternative splicing isoforms for RORC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RORC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RORC Expression
    About this image


    RORC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
    RORC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RORC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.256022

    UniProtKB/Swiss-Prot: RORG_HUMAN, P51449
    Tissue specificity: Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly
    expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RORC: 
              Innate & Adaptive Immune Responses in human mouse rat
              Th17 Response in human mouse rat
              Circadian Rhythms in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
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    Search QuantiFast Probe-based Assays in human, mouse, rat RORC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RORC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RORC gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rorc1 , 5 RAR-related orphan receptor gamma1, 5 87.21(n)1
    89.15(a)1
      3 (40.56 cM)5
    198851  NM_011281.21  NP_035411.21 
     943727945 
    chicken
    (Gallus gallus)
    Aves RORC6
    RAR-related orphan receptor C
    55(a)
    1 ↔ 1
    25(2153367-2157368)
    lizard
    (Anolis carolinensis)
    Reptilia RORC6
    RAR-related orphan receptor C
    56(a)
    1 ↔ 1
    GL344174.1(18718-28995)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000048471 nuclear receptor ROR-alpha-like 55.65(n)
    51.2(a)
      100004847  XM_001344013.3  XP_001344049.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hr466
    Hormone receptor-like in 46
    18(a)
    1 → many
    2R(6091617-6124853)
    worm
    (Caenorhabditis elegans)
    Secernentea nhr-236
    Protein NHR-23, isoform f
    24(a)
    1 → many
    I(7214745-7221781) WBGene00003622


    ENSEMBL Gene Tree for RORC (if available)
    TreeFam Gene Tree for RORC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RORC gene
    VDR2  PPARD2  RARG2  NR1I22  PPARA2  THRB2  RARA2  NR1H42  
    NR1D22  RARB2  RORA2  RORB2  NR1D12  NR1I32  PPARG2  NR1H22  
    THRA2  NR1H32  
    Selected SIMAP similar genes for RORC using alignment to 4 protein entries:     RORG_HUMAN (see all proteins) (see all similar genes):
    NR1F3    NR3C2    VDR    HNF4G    PPARG    HNF4alpha
    THRB    RORA    RORB    NR1F1    NR1F2    NR1I3
    NR1H3    ESR1    NR4A2    NR2C2    DKFZp779O0162    RARG

    Find genes that share paralogs with RORC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RORC (see all 691)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs356310941,2
    C--151781713(+) TAAAAA/-TACAA 2 -- int12Minor allele frequency- -:0.25NA 4
    rs1123126581,2
    C,F--151789608(+) CGCGC-/GCTTGTG 2 -- int12Minor allele frequency- GC:0.33CSA 6
    rs113672131,2
    C--151797528(+) GGCTTC/-CCTTC 2 -- int12Minor allele frequency- -:0.00NA 4
    rs105510611,2
    C--151801455(+) aaaaa-/AAAaaaaa 2 -- int1 cds11Minor allele frequency- AAA:0.00NA 2
    rs1882388061,2
    C--158281943(+) TGGAAC/TGGGGT 2 -- ut310--------
    rs412637281,2
    C--158281944(+) GGAACA/G/TGGGTC 4 -- ut310--------
    rs1817304801,2
    C--158281993(+) AGTCCC/TTCTTC 2 -- ut310--------
    rs1383082091,2
    C--158282083(+) GACCAC/TGATGG 4 M V mis11Minor allele frequency- T:0.00NA 4552
    rs2005310291,2
    C--158282154(+) TCCCCT/CTGGGT 4 /K /R mis11Minor allele frequency- C:0.00EU 1323
    rs1862905681,2
    --158282227(+) GAAGTC/TCGCTC 2 -- int10--------

    HapMap Linkage Disequilibrium report for RORC (151778547 - 151804348 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RORC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv160848CNV Loss16902084
    nsv516369CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RORC
    DNA2.0 Custom Variant and Variant Library Synthesis for RORC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602943    OMIM disorders: --

    2 diseases for RORC:    
    About MalaCards
    red color blindness    color blindness

    2 diseases from the University of Copenhagen DISEASES database for RORC:
    Red color blindness     Anus neoplasm

    Find genes that share disorders with RORC           About GenesLikeMe

    Genetic Association Database (GAD): RORC
    Human Genome Epidemiology (HuGE) Navigator: RORC (3 documents)

    Export disorders for RORC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RORC gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with RORC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle. (PubMed id 7811290)1, 2, 3 Hirose T.... Jetten A.M. (Biochem. Biophys. Res. Commun. 1994)
    2. Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. (PubMed id 20203100)1, 2 Jin L.... Li Y. (Mol. Endocrinol. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Candidate gene analysis in primary lymphedema. (PubMed id 18564921)1, 4 Ferrell R.E....Finegold D.N. (Lymphat Res Biol 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Molecular screening and association studies of retinoid-related orphan receptor gamma (RORC): a positional and functional candidate for type 2 diabetes. (PubMed id 12855222)1, 9 Wang H....Elbein S.C. (Mol. Genet. Metab. 2003)
    7. Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene. (PubMed id 9403063)1, 9 Medvedev A....Jetten A.M. (Genomics 1997)
    8. Defective TH17 development in human neonatal T cells involves reduced RORC2 mRNA content. (PubMed id 23726039)1 de Roock S....Boes M. (J. Allergy Clin. Immunol. 2013)
    9. Loss of RORI^t DNA binding activity inhibits IL-17 expression in HIV-1 infected Indian individuals. (PubMed id 23409930)1 Singh A....Chauhan N.K. (Viral Immunol. 2013)
    10. Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORI+ and RORI^ and its potential relevance to human liver diseases. (PubMed id 23211525)1 Ou Z....Xie W. (Mol. Endocrinol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6097 HGNC: 10260 AceView: RORC Ensembl:ENSG00000143365 euGenes: HUgn6097
    ECgene: RORC Kegg: 6097 H-InvDB: RORC

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RORC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RORC gene:
    Search GeneIP for patents involving RORC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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