RORC Gene
protein-coding GIFtS: 63
GCID: GC01M151778
|
|
RAR-related orphan receptor C
| |
Aliases
for RORC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAR-Related Orphan Receptor C1 2 | | RZR-GAMMA2 | | RORG1 2 3 5 | | Nuclear Receptor ROR-Gamma2 | | RZRG1 2 3 5 | | RAR-Related Orphan Nuclear Receptor Variant 22 | | NR1F31 2 3 | | Retinoic Acid-Binding Receptor Gamma2 | | TOR1 2 | | Retinoid-Related Orphan Receptor Gamma2 | | Nuclear Receptor RZR-Gamma2 3 | | Retinoid-Related Orphan Receptor-Gamma3 | | Nuclear Receptor Subfamily 1 Group F Member 32 3 | | |
Export aliases for RORC gene to outside databasesPrevious GC identifers: GC01M149620 GC01M147561 GC01M148553 GC01M148995 GC01M148997 GC01M148592 GC01M150040 GC01M150046 GC01M123155 |
Summaries
for RORC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RORC:
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclearhormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in micehave shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role inthymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression ofFas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RORG_HUMAN, P51449Function: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivatorsrecruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymphnodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expressionof several components of the circadian clock
Gene Wiki entry for RORC (RAR-related orphan receptor gamma)
|
Genomic Views
for RORC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RORC gene promoter:
AP-1 ATF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RORC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RORC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21RORC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M151778: view genomic region
(about GC identifiers)
Start:
|
151,778,547 bp from pter |
End:
|
151,804,348 bp from pter |
Size:
|
25,802 bases |
Orientation:
|
minus strand |
|
Proteins
for RORC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RORG_HUMAN, P51449 (See
protein sequence)Recommended Name: Nuclear receptor ROR-gamma Size: 518 amino acids; 58195 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAA64751.1; Type=Frameshift; Positions=516;
4 PDB 3D structures from  and Proteopedia  for RORC:3B0W (3D)
3KYT (3D)
3L0J (3D)
3L0L (3D)
Secondary accessions: Q5SZR9 Q8N5V7 Q8NCY8Alternative splicing: 2 isoforms: P51449-1 P51449-2 Explore the universe of human proteins at neXtProt for RORC: NX_P51449
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51449
RORC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001001523.1 NP_005051.2
ENSEMBL proteins: ENSP00000349164 ENSP00000327025 ENSP00000376461 Reactome Protein details: P51449
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RORC for ontologies About GeneDecksing
RORC Antibody Products:
Assay Products for RORC: |
Protein
Domains /
Families
for RORC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RORC for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P51449ProtoNet protein and cluster: P51449 2 Blocks protein families: IPB001723 Steroid hormone receptor signature IPB003079 Nuclear receptor ROR family (1F nuclear receptor) signature
UniProtKB/Swiss-Prot: RORG_HUMAN, P51449Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamilySimilarity: Contains 1 nuclear receptor DNA-binding domain |
Function
for RORC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RORG_HUMAN, P51449Function: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivatorsrecruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymphnodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expressionof several components of the circadian clock Genatlas biochemistry entry for RORC:RAR related orphan receptor,ligand activated transcription factor,highly expressed in skeletal muscle,steroid/thyroidretinoic receptor superfamily
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RORC (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RORC (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for RORC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RORC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RORC |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
TAS | 7811290 | | GO:0003707 | steroid hormone receptor activity |
IEA | -- | | GO:0004879 | ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
-- | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
RORC for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RORC:
Animal Models:
Mouse knock-outs for RORC: Rorctm1Litt Rorctm1Amj
8 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Rorc):
RORC for phenotypes About GeneDecksing
|
Pathways & Interactions
for RORC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mucin expression in CF via IL-6, IL-17 signaling pathways | | | 2 | Nuclear Receptor transcription pathway | | | 3 | Generic Transcription Pathway | | | 4 | Th17 Differentiation | | | 5 | Circadian rhythm - mammal | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  R&D Systems Pathways for RORC
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RORC
4  GeneGo (Thomson Reuters) Pathways for RORC
1  BioSystems Pathway for RORC
3 
Reactome Pathways for RORC
1 
Kegg Pathway (Kegg details for RORC):
RORC for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RORC
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/56 Interacting proteins for RORC (P514493 ENSP000003270254) via UniProtKB, MINT, STRING, and/or I2D (see all 56)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006367 | transcription initiation from RNA polymerase II promoter |
TAS | -- | | GO:0006468 | protein phosphorylation |
IEA | -- | | GO:0010467 | gene expression |
TAS | -- | | GO:0030154 | cell differentiation |
-- | -- | | GO:0030522 | intracellular receptor mediated signaling pathway |
TAS | 7811290 |
RORC for ontologies About GeneDecksing
|
Drugs & Compounds
for RORC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RORC
Search CenterWatch for drugs/clinical trials and news about RORC / RORG
|
Transcripts
for RORC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RORC gene (2 alternative transcripts): NM_001001523.1 NM_005060.3 Unigene Cluster for RORC: RAR-related orphan receptor C Hs.256022 [show with all ESTs]Unigene Representative Sequence: NM_0050604 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000356728(uc001ezg.3 uc001ezh.3 uc010pdo.2 uc010pdp.2)
ENST00000318247 ENST00000480719 ENST00000392697
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RORC (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RORC (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RORC (NM_005060) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RORC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RORC |
Additional cDNA sequence: AB307696.1 AF075096.1 AK097994.1 AK223137.1 AK298460.1 AK315662.1 AL834219.1 BC031554.1 BC110571.2 CR457436.1 HQ692834.1 U16997.1 4 DOTS entries: DT.211192 DT.102842425 DT.101976876 DT.121326057 24/71 AceView cDNA sequences (see all 71): BX091308 AK097994 BM856735 NM_001001523 BP368095 AK128522 BQ447902 BI256620 CD619720 BM967010 AA286679 CB150444 BM967033 AL834219 BU526834 H59326 BC031554 NM_005060 CR457436 BP356797 BP368501 BQ772251 CD619723 AA179004
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RORC (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
|---|
|
| SP1: | | | - | | - | | - | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RORC
|
Expression
for RORC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RORC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RORC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RORC
SOURCE GeneReport for Unigene cluster: Hs.256022
UniProtKB/Swiss-Prot: RORG_HUMAN, P51449Tissue specificity: Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed inskeletal muscle. Isoform 2 is primarily expressed in immature thymocytes
SABiosciences Expression via Pathway-Focused PCR Arrays including RORC:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RORC
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RORC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RORC | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RORC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RORC |
Orthologs
for RORC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RORC gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC7773551 |
nuclear receptor ROR-gamma-like |
68.47(n)
65.96(a) |
|
777355 XM_003642708.1 XP_003642756.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RORC6 |
-- |
62(a) |
1 ↔ 1 |
GL344174.1(18724-28943) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:dkey-80m2.26 |
si:dkey-80m2.2 |
46(a) |
1 ↔ 1 |
16(19977008-20150570) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Hr466 |
Hormone receptor-like in 46 |
18(a) |
1 → many |
2R(6091617-6124853) |
worm
(Caenorhabditis elegans) |
Secernentea |
nhr-236 |
Nuclear hormone receptor family member nhr-23 |
22(a) |
1 → many |
I(7214743-7221346) |
ENSEMBL Gene Tree for RORC (if available)
TreeFam Gene Tree for RORC (if available) |
Paralogs
for RORC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RORC gene
- NR1D22 PPARD2 RORA2 NR1D12 PPARA2 RORB2 PPARG2
18/22 SIMAP similar genes for RORC using alignment to 4 protein entries: RORG_HUMAN (see all proteins)
(see all similar genes):NR1F3 NR3C2 VDR HNF4G PPARA PPARG
HNF4alpha THRB RORA RORB NR1F1 NR1F2
NR1I3 NR1H3 ESR1 NR4A2 NR2C2 DKFZp779O0162
RORC for paralogs About GeneDecksing
|
Genomic Variants
for RORC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RORC (151778547 - 151804348 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RORC
1 CNV: 5523 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RORC |
|
Disorders
/ Diseases
for RORC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RORC for disorders About GeneDecksing
OMIM gene information: 602943
OMIM disorders: --
15  diseases for RORC: About MalaCardsred color blindness color blindness anus neoplasm spontaneous abortion
contact dermatitis allergic rhinitis intrahepatic cholangiocarcinoma lymphedema
rhinitis blindness acne dermatitis
cholangiocarcinoma gastric cancer thyroiditis
2 diseases from the University of Copenhagen DISEASES database for RORC:Red color blindness Anus neoplasm Human Genome Epidemiology (HuGE) Navigator: RORC (3 documents)
Export disorders for RORC gene to outside databases
|
Publications
for RORC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RORC gene, integrated from 9 sources (see all 51):
(articles sorted by number of sources associating them with RORC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle. (PubMed id 7811290)1, 2, 3 Hirose T.... Jetten A.M. (1994)
- Structural basis for hydroxycholesterols as natural l igands of orphan nuclear receptor RORgamma. (PubMed id 20203100)1, 2 Jin L....Li Y. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular screening and association studies of retinoid-related orphan receptor gamma (RORC): a positional and functional candidate for type 2 diabetes. (PubMed id 12855222)1, 9 Wang H....Elbein S.C. (2003)
- Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene. (PubMed id 9403063)1, 9 Medvedev A....Jetten A.M. (1997)
- Possible genetic predisposition to lymphedema after br east cancer. (PubMed id 22404826)1 Newman B....Hayes S.C. (2012)
- Upstream stimulating factors regulate the expression o f RORgT in human lymphocytes. (PubMed id 22891280)1 Ratajewski M....Dastych J. (2012)
- A novel isoform of the orphan receptor RORgt suppresse s IL-17 production in human T cells. (PubMed id 22237416)1 Rauen T....Tsokos G.C. (2012)
- CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORgt recruitment to the IL17A promoter in human T lym phocytes. (PubMed id 22989874)1 Chatterjee M....Tsokos G.C. (2012)
- Rarity of human T helper 17 cells is due to retinoic a cid orphan receptor-dependent mechanisms that limit their expansion. (PubMed id 22326581)1 Santarlasci V....Annunziato F. (2012)
|
External Searches for RORC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RORC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RORC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RORC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RORC | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RORC gene:
Search GeneIP for patents involving RORC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RORC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RORC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RORC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RORC | | | OriGene Protein Over-expression Lysate for RORC | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RORC | | OriGene 3'-UTR Clone for RORC | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RORC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RORC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RORC | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RORC | | OriGene Custom Protein Services for RORC | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RORC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RORC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RORC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RORC | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RORC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RORC |
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| | | | Search Tocris compounds for RORC |
| |  |  |  |  | | | | | | Recombinant Protein for RORC |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RORC |
|  |  |  | | | | ThermoFisher Antibodies for RORC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RORC |
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