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Aliases for RORB Gene

Aliases for RORB Gene

  • RAR-Related Orphan Receptor B 2 3
  • RZRB 3 4 6
  • Nuclear Receptor Subfamily 1 Group F Member 2 3 4
  • Retinoid-Related Orphan Receptor-Beta 3 4
  • Nuclear Receptor RZR-Beta 3 4
  • NR1F2 3 4
  • Retinoid-Related Orphan Receptor Beta 3
  • Retinoic Acid-Binding Receptor Beta 3
  • RAR-Related Orphan Receptor Beta 3
  • Nuclear Receptor ROR-Beta 3
  • BA133M9.1 3
  • ROR-BETA 3
  • RZR-BETA 3

External Ids for RORB Gene

Summaries for RORB Gene

Entrez Gene Summary for RORB Gene

  • The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]

GeneCards Summary for RORB Gene

RORB (RAR-Related Orphan Receptor B) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and steroid hormone receptor activity. An important paralog of this gene is NR1I2.

UniProtKB/Swiss-Prot for RORB Gene

  • Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5-AGGTCA-3 preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).

  • Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity).

Gene Wiki entry for RORB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RORB Gene

Genomics for RORB Gene

Genomic Location for RORB Gene

Start:
74,497,336 bp from pter
End:
74,693,177 bp from pter
Size:
195,842 bases
Orientation:
Plus strand

Genomic View for RORB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RORB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RORB Gene

Regulatory Elements for RORB Gene

Proteins for RORB Gene

  • Protein details for RORB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92753-RORB_HUMAN
    Recommended name:
    Nuclear receptor ROR-beta
    Protein Accession:
    Q92753
    Secondary Accessions:
    • Q8WX73

    Protein attributes for RORB Gene

    Size:
    470 amino acids
    Molecular mass:
    53220 Da
    Quaternary structure:
    • Monomer. Interacts with CRX (By similarity).

    Alternative splice isoforms for RORB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RORB Gene

Proteomics data for RORB Gene at MOPED

Post-translational modifications for RORB Gene

No Post-translational modifications

Other Protein References for RORB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RORB Gene

Domains for RORB Gene

Gene Families for RORB Gene

HGNC:
  • NR :Nuclear hormone receptors
IUPHAR :

UniProtKB/Swiss-Prot:

RORB_HUMAN
Domain:
  • AF-2 (activation function-2) motif is required for recruiting coregulators containing the LXXLL motif, such as NCOA1, and control the transactivational activity.:
    • Q92753
  • Contains 1 nuclear receptor DNA-binding domain.:
    • Q92753
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.:
    • Q92753
genes like me logo Genes that share domains with RORB: view

Function for RORB Gene

Molecular function for RORB Gene

GENATLAS Biochemistry: RAR related orphan receptor B,expressed in areas of the central nervous system,involved in the processing of sensory information and in the components of mammalian timing system,the suprachiasmatic nuclei,retina and pineal gland,steroid/thyroid retinoic receptor superfamily
UniProtKB/Swiss-Prot Function: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5-AGGTCA-3 preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).
UniProtKB/Swiss-Prot Function: Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity).

Gene Ontology (GO) - Molecular Function for RORB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity ISS --
GO:0003707 steroid hormone receptor activity IEA --
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA --
GO:0005515 protein binding IPI 23555304
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with RORB: view
genes like me logo Genes that share phenotypes with RORB: view

miRNA for RORB Gene

miRTarBase miRNAs that target RORB

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RORB Gene

Localization for RORB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RORB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RORB Gene COMPARTMENTS Subcellular localization image for RORB gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for RORB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with RORB: view

Pathways for RORB Gene

genes like me logo Genes that share pathways with RORB: view

Pathways by source for RORB Gene

1 Qiagen pathway for RORB Gene
1 KEGG pathway for RORB Gene

Gene Ontology (GO) - Biological Process for RORB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 7935491
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007601 visual perception IEA --
GO:0010467 gene expression TAS --
GO:0030522 intracellular receptor signaling pathway TAS 7935491
genes like me logo Genes that share ontologies with RORB: view

Compounds for RORB Gene

(1) Drugbank Compounds for RORB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Melatonin
  • MEL
73-31-4 target agonist

(3) IUPHAR Ligand for RORB Gene

Ligand Type Action Affinity Pubmed IDs
all-trans-retinoic acid Agonist Agonist 9.4
all-trans-4-oxo-retinoic acid Antagonist Antagonist 9.3
ALRT 1550 Antagonist Antagonist

(2) Novoseek inferred chemical compound relationships for RORB Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 61.5 1
stearic acid 57.4 2
genes like me logo Genes that share compounds with RORB: view

Transcripts for RORB Gene

mRNA/cDNA for RORB Gene

Unigene Clusters for RORB Gene

RAR-related orphan receptor B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RORB Gene

No ASD Table

Relevant External Links for RORB Gene

GeneLoc Exon Structure for
RORB
ECgene alternative splicing isoforms for
RORB

Expression for RORB Gene

mRNA expression in normal human tissues for RORB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RORB Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (8.4) and Brain - Cortex (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RORB Gene

SOURCE GeneReport for Unigene cluster for RORB Gene Hs.494178

genes like me logo Genes that share expressions with RORB: view

Orthologs for RORB Gene

This gene was present in the common ancestor of animals.

Orthologs for RORB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RORB 36
  • 99.71 (n)
  • 100 (a)
RORB 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RORB 36
  • 95.13 (n)
  • 98.91 (a)
RORB 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RORB 36
  • 93.54 (n)
  • 96.95 (a)
RORB 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rorb 36
  • 92.96 (n)
  • 98.26 (a)
Rorb 16
Rorb 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RORB 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RORB 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rorb 36
  • 94.05 (n)
  • 98.26 (a)
chicken
(Gallus gallus)
Aves RORB 36
  • 88.53 (n)
  • 96.95 (a)
RORB 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RORB 37
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rorb 36
  • 83.19 (n)
  • 93.23 (a)
zebrafish
(Danio rerio)
Actinopterygii rorb 36
  • 75.07 (n)
  • 85.53 (a)
rorb 37
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009002 36
  • 53.73 (n)
  • 49.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hr46 36
  • 48.69 (n)
  • 40.78 (a)
Hr46 37
  • 19 (a)
OneToMany
Hr46 38
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea nhr-23 36
  • 50.06 (n)
  • 46.44 (a)
nhr-23 37
  • 25 (a)
OneToMany
nhr-23 38
  • 75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
OneToMany
Species with no ortholog for RORB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RORB Gene

ENSEMBL:
Gene Tree for RORB (if available)
TreeFam:
Gene Tree for RORB (if available)

Paralogs for RORB Gene

Selected SIMAP similar genes for RORB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RORB: view

Variants for RORB Gene

Sequence variations from dbSNP and Humsavar for RORB Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1849 -- 74,646,015(-) TTAGA(G/T)GCCCA intron-variant
rs140801 -- 74,653,805(-) CTAGA(-/TAGA)CATTT intron-variant
rs717299 -- 74,571,017(-) TTTTC(C/T)ATCTA intron-variant
rs871178 -- 74,557,292(+) GAGAC(A/G)GAGCT intron-variant
rs871179 -- 74,557,319(+) AGACA(C/T)GAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RORB Gene

Variant ID Type Subtype PubMed ID
nsv893463 CNV Gain 21882294
nsv831622 CNV Gain 17160897
dgv487n21 CNV Gain 19592680
nsv893464 CNV Gain 21882294
esv2677308 CNV Deletion 23128226
esv2738557 CNV Deletion 23290073
esv2738558 CNV Deletion 23290073
esv990769 CNV Deletion 20482838
esv2738559 CNV Deletion 23290073
esv1321162 CNV Deletion 17803354
nsv517655 CNV Loss 19592680
nsv831623 CNV Gain+Loss 17160897
nsv6567 CNV Loss 18451855

Relevant External Links for RORB Gene

HapMap Linkage Disequilibrium report
RORB

Disorders for RORB Gene

Relevant External Links for RORB

Genetic Association Database (GAD)
RORB
Human Genome Epidemiology (HuGE) Navigator
RORB
genes like me logo Genes that share disorders with RORB: view

No data available for UniProtKB/Swiss-Prot for RORB Gene

Publications for RORB Gene

  1. Evidence for genetic association of RORB with bipolar disorder. (PMID: 19909500) McGrath C.L. … Tsuang M.T. (BMC Psychiatry 2009) 3 23 49
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. (PMID: 12958591) Stehlin-Gaon C. … SchA1le R. (Nat. Struct. Biol. 2003) 3 23
  4. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. (PMID: 19839995) Mansour H.A. … Nimgaonkar V.L. (Bipolar Disord 2009) 3 49
  5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 49

Products for RORB Gene

Sources for RORB Gene

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