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RORB Gene

protein-coding   GIFtS: 61
GCID: GC09P077112

RAR-Related Orphan Receptor B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAR-Related Orphan Receptor B1 2     RZR-BETA2
RZRB2 3 5     bA133M9.12
Nuclear Receptor RZR-Beta2 3     Nuclear Receptor ROR-Beta2
Nuclear Receptor Subfamily 1 Group F Member 22 3     RAR-Related Orphan Receptor Beta2
Retinoid-Related Orphan Receptor-Beta2 3     Retinoic Acid-Binding Receptor Beta2
NR1F22 3     Retinoid-Related Orphan Receptor Beta2
ROR-BETA2     

External Ids:    HGNC: 102591   Entrez Gene: 60962   Ensembl: ENSG000001989637   OMIM: 6019725   UniProtKB: Q927533   

Export aliases for RORB gene to outside databases

Previous GC identifers: GC09P068156 GC09P068968 GC09P070682 GC09P072569 GC09P074341 GC09P076302 GC09P046935


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RORB Gene:
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a
DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several
genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a
nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression
of some genes involved in circadian rhythm. (provided by RefSeq, Feb 2014)

GeneCards Summary for RORB Gene:
RORB (RAR-related orphan receptor B) is a protein-coding gene. GO annotations related to this gene include steroid hormone receptor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is VDR.

UniProtKB/Swiss-Prot: RORB_HUMAN, Q92753
Function: Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells.
Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW
promoter (By similarity)

Gene Wiki entry for RORB (RAR-related orphan receptor beta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RORB gene promoter:
         Egr-3   Nkx2-2   CUTL1   AREB6   PPAR-gamma1   HFH-1   IRF-7A   Cart-1   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRORB promoter sequence
   Search Chromatin IP Primers for RORB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RORB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q22

RORB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RORB gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P077112:  view genomic region     (about GC identifiers)

Start:
77,112,252 bp from pter      End:
77,308,093 bp from pter
Size:
195,842 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RORB_HUMAN, Q92753 (See protein sequence)
Recommended Name: Nuclear receptor ROR-beta  
Size: 470 amino acids; 53220 Da
Secondary accessions: Q8WX73
Alternative splicing: 2 isoforms:  Q92753-2   Q92753-1   

Explore the universe of human proteins at neXtProt for RORB: NX_Q92753

Explore proteomics data for RORB at MOPED


See RORB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_008845.2  
ENSEMBL proteins: 
 ENSP00000366093   ENSP00000379507  
Reactome Protein details: Q92753

RORB Human Recombinant Protein Products:

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Novus Biologicals RORB Proteins
Novus Biologicals RORB Lysates
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Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for RORB 

 
antibodies-online proteins for RORB (7 products) 

 
antibodies-online peptides for RORB

RORB Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of RORB
R&D Systems Antibodies for RORB (ROR beta/NR1F2)
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Novus Biologicals RORB Antibodies
Abcam antibodies for RORB (Q92753, Q58EY0)
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ThermoFisher Antibodies for RORB
antibodies-online antibodies for RORB (57 products) 

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Search eBioscience for ELISAs for RORB 
antibodies-online kits for RORB (6 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
NR: Nuclear hormone receptors

IUPHAR Guide to PHARMACOLOGY protein family classification: RAR-related orphan receptor-beta
1F. RAR-related orphan receptors

Selected InterPro protein domains (see all 6):
 IPR013088 Znf_NHR/GATA
 IPR008946 Nucl_hormone_rcpt_ligand-bd
 IPR000536 Nucl_hrmn_rcpt_lig-bd_core
 IPR001628 Znf_hrmn_rcpt
 IPR001723 Str_hrmn_rcpt

Graphical View of Domain Structure for InterPro Entry Q92753

ProtoNet protein and cluster: Q92753

2 Blocks protein domains:
IPB001723 Steroid hormone receptor signature
IPB003079 Nuclear receptor ROR family (1F nuclear receptor) signature


UniProtKB/Swiss-Prot: RORB_HUMAN, Q92753
Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
Similarity: Contains 1 nuclear receptor DNA-binding domain


Find genes that share domains with RORB           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RORB_HUMAN, Q92753
Function: Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells.
Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW
promoter (By similarity)

     Genatlas biochemistry entry for RORB:
RAR related orphan receptor B,expressed in areas of the central nervous system,involved in the processing of
sensory information and in the components of mammalian timing system,the suprachiasmatic nuclei,retina and pineal
gland,steroid/thyroid retinoic receptor superfamily

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003700sequence-specific DNA binding transcription factor activity ISS--
GO:0003707steroid hormone receptor activity IEA--
GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
GO:0005515protein binding IPI--
GO:0008270zinc ion binding IEA--
     
Find genes that share ontologies with RORB           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for RORB:
 Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

     6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Rorb):
 behavior/neurological  growth/size/body  nervous system  normal  reproductive system 
 vision/eye 

Find genes that share phenotypes with RORB           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for RORB

miRNA
Products:
    
miRTarBase miRNAs that target RORB:
hsa-mir-26b-5p (MIRT030014), hsa-mir-335-5p (MIRT018866)

Block miRNA regulation of human, mouse, rat RORB using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate RORB (see all 57):
hsa-miR-3130-5p hsa-miR-520e hsa-miR-302d hsa-miR-548k hsa-miR-199a-3p hsa-miR-219-5p hsa-miR-374a hsa-miR-764
SwitchGear 3'UTR luciferase reporter plasmidRORB 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for RORB
Predesigned siRNA for gene silencing in human, mouse, rat RORB

Gene Editing
Products:
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Clone
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OriGene clones in human, mouse for RORB (see all 8)
OriGene ORF clones in mouse, rat for RORB
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GenScript: all cDNA clones in your preferred vector: RORB (NM_006914)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for RORB
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RORB

Cell Line
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Browse ESI BIO Cell Lines and PureStem Progenitors for RORB 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RORB


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RORB_HUMAN, Q92753: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ISS--
GO:0005654nucleoplasm TAS--

Find genes that share ontologies with RORB           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RORB About    
See pathways by source

SuperPathContained pathways About
1Gene Expression
Generic Transcription Pathway0.40
Gene Expression0.40
2Sweet Taste Signaling
Melatonin Signaling0.72
3Nuclear Receptor transcription pathway
Nuclear Receptor transcription pathway0.67
4Circadian rhythm
Circadian rhythm0.31


Find genes that share SuperPaths with RORB           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RORB
    Melatonin Signaling

1 Reactome Pathway for RORB
    Nuclear Receptor transcription pathway


1 Kegg Pathway  (Kegg details for RORB):
    Circadian rhythm

    Pathway & Disease-focused RT2 Profiler PCR Arrays including RORB: 
          Circadian Rhythms in human mouse rat
          Tumor Metastasis in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for RORB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for RORB (Q927531, 3 ENSP000003660934) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
InteractantInteraction Details
GeneCardExternal ID(s)
NME2P223923, ENSP000003655724I2D: score=1 STRING: ENSP00000365572
NME1P155313, ENSP000000130344I2D: score=2 STRING: ENSP00000013034
NRIP2Q9BQI93, ENSP000003375014I2D: score=2 STRING: ENSP00000337501
HRO435933, ENSP000003708264I2D: score=1 STRING: ENSP00000370826
NME1-NME2P223923I2D: score=1 
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Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006355regulation of transcription, DNA-templated TAS7935491
GO:0006367transcription initiation from RNA polymerase II promoter TAS--
GO:0007601visual perception IEA--
GO:0010467gene expression TAS--
GO:0030522intracellular receptor signaling pathway TAS7935491

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RORB

1 DrugBank Compound for RORB    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
MelatoninMEL (see all 4)73-31-4targetagonist7961794

3 IUPHAR Ligands for RORB (RAR-related orphan receptor-beta)    About this table
LigandTypeActionAffinityPubmed IDs
all-trans-4-oxo-retinoic acid
AntagonistAntagonist9.312958591
ALRT 1550
AntagonistAntagonist6.812958591
all-trans-retinoic acid
AntagonistAntagonist6.5512958591

2 Novoseek inferred chemical compound relationships for RORB gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid 61.5 1 12958591 (1)
stearic acid 57.4 2 12649431 (1), 11689423 (1)



Find genes that share compounds with RORB           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for RORB gene: 
NM_006914.3  

Unigene Cluster for RORB:

RAR-related orphan receptor B
Hs.494178  [show with all ESTs]
Unigene Representative Sequence: BX647070
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000376896(uc004ajh.3) ENST00000396204(uc004aji.3)
miRNA
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Block miRNA regulation of human, mouse, rat RORB using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate RORB (see all 57):
hsa-miR-3130-5p hsa-miR-520e hsa-miR-302d hsa-miR-548k hsa-miR-199a-3p hsa-miR-219-5p hsa-miR-374a hsa-miR-764
SwitchGear 3'UTR luciferase reporter plasmidRORB 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat RORB
Clone
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OriGene ORF clones in mouse, rat for RORB
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GenScript: all cDNA clones in your preferred vector: RORB (NM_006914)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RORB
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RORB
Primer
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OriGene qPCR primer pairs and template standards for RORB
OriGene qSTAR qPCR primer pairs in human, mouse for RORB
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RORB
  QuantiTect SYBR Green Assays in human, mouse, rat RORB
  QuantiFast Probe-based Assays in human, mouse, rat RORB

Additional mRNA sequence: 

AB307695.1 AK313431.1 BC051830.1 BC093772.1 BC093774.1 BX647070.1 HQ709186.1 Y08639.1 

3 DOTS entries:

DT.438580  DT.40123208  DT.75109175 

Selected AceView cDNA sequences (see all 35):

CN482093 BU169404 CA397109 NM_006914 AI768825 BM698896 AL118995 AL712390 
BQ189123 CR594193 BC051830 BM929808 BG185895 BX647070 BX348312 BM669680 
D61627 AL711967 Y08639 AL691650 AL691651 F05544 CK299107 AA319114 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RORB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
RORB Expression
About this image


RORB expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Neurons
         Rod Precursor Cells Outer Nuclear Layer
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         Rod Precursor Cells Outer Nuclear Layer
 
 Neural Tube (Nervous System)    fully expand to see all 4 entries
         Metencephalon
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Myoblasts Mandibular Arch Muscles
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Cerebellum
RORB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RORB Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.494178
    Pathway & Disease-focused RT2 Profiler PCR Arrays including RORB: 
          Circadian Rhythms in human mouse rat
          Tumor Metastasis in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for RORB
OriGene qSTAR qPCR primer pairs in human, mouse for RORB
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RORB
QuantiTect SYBR Green Assays in human, mouse, rat RORB
QuantiFast Probe-based Assays in human, mouse, rat RORB
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RORB

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for RORB gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rorb1 , 5 RAR-related orphan receptor beta1, 5 92.96(n)1
98.26(a)1
  19 (13.28 cM)5
2259981  NM_001043354.21  NP_001036819.11 
 189306055 
chicken
(Gallus gallus)
Aves RORB1 RAR-related orphan receptor B 88.53(n)
96.95(a)
  395980  NM_205093.1  NP_990424.1 
lizard
(Anolis carolinensis)
Reptilia RORB6
RAR-related orphan receptor B
97(a)
1 ↔ 1
2(47043636-47090177)
tropical clawed frog
(Xenopus tropicalis)
Amphibia rorb1 RAR-related orphan receptor B 83.19(n)
93.23(a)
  100487062  XM_002940031.2  XP_002940077.1 
zebrafish
(Danio rerio)
Actinopterygii rorb1 RAR-related orphan receptor B 75.07(n)
85.53(a)
  567943  NM_001082856.1  NP_001076325.1 
fruit fly
(Drosophila melanogaster)
Insecta Hr461 , 3 ligand-dependent nuclear receptor3
Hormone receptor-like in 461
38(a)3
48.69(n)1
40.78(a)1
  360731  NM_176123.41  NP_788303.11 
worm
(Caenorhabditis elegans)
Secernentea nhr-231 , 3 nuclear hormone receptor3
nhr-231
75(a)3
50.06(n)1
46.44(a)1
  I(7228074-7228944)3
1724601  NM_001037882.31  NP_001032971.11 


ENSEMBL Gene Tree for RORB (if available)
TreeFam Gene Tree for RORB (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RORB gene
VDR2  PPARD2  RARG2  NR1I22  PPARA2  THRB2  RARA2  NR1H42  
NR1D22  RARB2  RORA2  RORC2  NR1D12  NR1I32  PPARG2  NR1H22  
THRA2  NR1H32  
13 SIMAP similar genes for RORB using alignment to 2 protein entries:     RORB_HUMAN (see all proteins):
NR1F2    HNF4G    NR3C2    VDR    RORA    NR1F1
NR5A1    PPARG    RORC    NR1I3    NR1F3    RARG
NR1D2

Find genes that share paralogs with RORB           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RORB (see all 3455)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs43514731,2
C,H--77110552(+) TTTGTT/CTCTTG 1 -- us2k111Minor allele frequency- C:0.01NA WA CSA EA 372
rs1503503431,2
C--77110607(+) CATAAC/TTTTGT 1 -- us2k10--------
rs754239231,2
C,F--77110845(+) CACATT/CGGTTT 1 -- us2k11Minor allele frequency- C:0.10WA 118
rs1380124251,2
--77111326(+) ATAAAC/TGGTCA 1 -- us2k10--------
rs1169428921,2
F--77111339(+) GATGAC/TAATTT 1 -- us2k11Minor allele frequency- T:0.01NA 120
rs1490830561,2
C--77111385(+) AGTTAC/TCAATC 1 -- us2k10--------
rs1818491001,2
--77111450(+) CTGCAA/GTCACA 1 -- us2k10--------
rs1860119491,2
--77111519(+) CTGTTA/CTCCTT 1 -- us2k10--------
rs1907237161,2
--77111570(+) ATAAAA/TATCAA 1 -- us2k10--------
rs1819581711,2
--77111601(+) ATACAC/TGTTTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for RORB (77112252 - 77308093 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for RORB (see all 13):    About this table    
Variant IDTypeSubtypePubMed ID
esv2738557CNV Deletion23290073
esv1321162CNV Deletion17803354
esv2677308CNV Deletion23128226
esv990769CNV Deletion20482838
esv2738558CNV Deletion23290073
esv2738559CNV Deletion23290073
nsv517655CNV Loss19592680
nsv6567CNV Loss18451855
dgv487n21CNV Gain19592680
nsv831622CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RORB
DNA2.0 Custom Variant and Variant Library Synthesis for RORB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601972    OMIM disorders: --


Find genes that share disorders with RORB           About GenesLikeMe

Genetic Association Database (GAD): RORB
Human Genome Epidemiology (HuGE) Navigator: RORB (4 documents)

Export disorders for RORB gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RORB gene, integrated from 10 sources (see all 35):
(articles sorted by number of sources associating them with RORB)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Evidence for genetic association of RORB with bipolar disorder. (PubMed id 19909500)1, 4, 9 McGrath C.L....Tsuang M.T. (BMC Psychiatry 2009)
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
  4. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. (PubMed id 19839995)1, 4 Mansour H.A....Nimgaonkar V.L. (Bipolar Disord 2009)
  5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
  6. Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors. (PubMed id 7926749)1, 3 Giguere V.... Otulakowski G. (Genes Dev. 1994)
  7. All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. (PubMed id 12958591)1, 9 Stehlin-Gaon C....SchA1le R. (Nat. Struct. Biol. 2003)
  8. X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation. (PubMed id 11689423)1, 9 Stehlin C....Renaud J.P. (EMBO J. 2001)
  9. Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1). (PubMed id 11121580)1, 9 Gawlas K. and Stunnenberg H.G. (Biochim. Biophys. Acta 2000)
  10. Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells. (PubMed id 11504880)1, 9 Gawlas K. and Stunnenberg H.G. (Nucleic Acids Res. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6096 HGNC: 10259 AceView: RORB Ensembl:ENSG00000198963 euGenes: HUgn6096
ECgene: RORB Kegg: 6096 H-InvDB: RORB

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RORB Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RORB Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RORB gene:
Search GeneIP for patents involving RORB

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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