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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RORB Gene

protein-coding   GIFtS: 62
GCID: GC09P077112

RAR-Related Orphan Receptor B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAR-Related Orphan Receptor B1 2     RZR-BETA2
RZRB2 3 5     bA133M9.12
Nuclear Receptor RZR-Beta2 3     Nuclear Receptor ROR-Beta2
Nuclear Receptor Subfamily 1 Group F Member 22 3     RAR-Related Orphan Receptor Beta2
Retinoid-Related Orphan Receptor-Beta2 3     Retinoic Acid-Binding Receptor Beta2
NR1F22 3     Retinoid-Related Orphan Receptor Beta2
ROR-BETA2     

External Ids:    HGNC: 102591   Entrez Gene: 60962   Ensembl: ENSG000001989637   OMIM: 6019725   UniProtKB: Q927533   

Export aliases for RORB gene to outside databases

Previous GC identifers: GC09P068156 GC09P068968 GC09P070682 GC09P072569 GC09P074341 GC09P076302 GC09P046935


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RORB Gene:
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a
DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several
genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has
been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and
differentiation. (provided by RefSeq, Jul 2008)

GeneCards Summary for RORB Gene: 
RORB (RAR-related orphan receptor B) is a protein-coding gene. Diseases associated with RORB include bipolar i disorder, and schizoaffective disorder, and among its related super-pathways are Gene Expression and Sweet Taste Signaling. GO annotations related to this gene include steroid hormone receptor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is RORC.

UniProtKB/Swiss-Prot: RORB_HUMAN, Q92753
Function: Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells.
Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW
promoter (By similarity)

Gene Wiki entry for RORB (RAR-related orphan receptor beta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RORB gene promoter:
         Egr-3   Nkx2-2   CUTL1   AREB6   PPAR-gamma1   HFH-1   IRF-7A   Cart-1   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRORB promoter sequence
   Search SABiosciences Chromatin IP Primers for RORB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RORB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q22

RORB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RORB gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P077112:  view genomic region     (about GC identifiers)

Start:
77,112,252 bp from pter      End:
77,302,117 bp from pter
Size:
189,866 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RORB_HUMAN, Q92753 (See protein sequence)
Recommended Name: Nuclear receptor ROR-beta  
Size: 470 amino acids; 53220 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q8WX73
Alternative splicing: 2 isoforms:  Q92753-2   Q92753-1   

Explore the universe of human proteins at neXtProt for RORB: NX_Q92753

Explore proteomics data for RORB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92753

  • RORB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RORB Protein Expression
    REFSEQ proteins: NP_008845.2  
    ENSEMBL proteins: 
     ENSP00000366093   ENSP00000379507  
    Reactome Protein details: Q92753
    Human Recombinant Protein Products for RORB: 
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    Novus Biologicals RORB Proteins
    Novus Biologicals RORB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    RORB for ontologies           About GeneDecksing



    RORB Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: RAR-related orphan receptor-&beta 
    1F. RAR-related orphan receptors

    5/6 InterPro protein domains (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR001723 Str_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry Q92753

    ProtoNet protein and cluster: Q92753

    2 Blocks protein domains:
    IPB001723 Steroid hormone receptor signature
    IPB003079 Nuclear receptor ROR family (1F nuclear receptor) signature


    UniProtKB/Swiss-Prot: RORB_HUMAN, Q92753
    Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    RORB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RORB_HUMAN, Q92753
    Function: Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells.
    Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW
    promoter (By similarity)

         Genatlas biochemistry entry for RORB:
    RAR related orphan receptor B,expressed in areas of the central nervous system,involved in the processing of
    sensory information and in the components of mammalian timing system,the suprachiasmatic nuclei,retina and pineal
    gland,steroid/thyroid retinoic receptor superfamily

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity ISS--
    GO:0003707steroid hormone receptor activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
         
    RORB for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RORB:
     Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rorb):
     behavior/neurological  growth/size  nervous system  normal  reproductive system 
     vision/eye 

    RORB for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RORB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RORB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RORB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RORB 

    miRNA
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    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate RORB (see all 57):
    hsa-miR-3130-5p hsa-miR-520e hsa-miR-302d hsa-miR-548k hsa-miR-199a-3p hsa-miR-219-5p hsa-miR-374a hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidRORB 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RORB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    2Sweet Taste Signaling
    Melatonin Signaling0.72
    3Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.68
    4Circadian Clock
    Circadian rhythm0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RORB
        Melatonin Signaling

    3        Reactome Pathways for RORB
        Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    Gene Expression


    1         Kegg Pathway  (Kegg details for RORB):
        Circadian rhythm


    RORB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RORB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/61 Interacting proteins for RORB (Q927531, 3 ENSP000003660934) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME1P155313, ENSP000000130344I2D: score=2 STRING: ENSP00000013034
    NRIP2Q9BQI93, ENSP000003375014I2D: score=2 STRING: ENSP00000337501
    NME2P223923, ENSP000003655724I2D: score=1 STRING: ENSP00000365572
    NCOA1Q157883, ENSP000003209404I2D: score=2 STRING: ENSP00000320940
    MAP6Q96JE93I2D: score=3 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent TAS7935491
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007601visual perception IEA--
    GO:0010467gene expression TAS--
    GO:0030522intracellular receptor signaling pathway TAS7935491

    RORB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RORB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RORB

    1 DrugBank Compound for RORB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MelatoninMEL (see all 4)73-31-4targetagonist7961794

    3 IUPHAR Ligands for RORB (RAR-related orphan receptor-&beta)    About this table 
    LigandTypeActionAffinityPubmed IDs
    all-trans-4-oxo-retinoic acid
    Antagonist9.312958591
    ALRT 1550
    AntagonistAntagonist6.812958591
    all-trans-retinoic acid
    AntagonistAntagonist6.5512958591

    2 Novoseek inferred chemical compound relationships for RORB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 61.5 1 12958591 (1)
    stearic acid 57.4 2 12649431 (1), 11689423 (1)

    Search CenterWatch for drugs/clinical trials and news about RORB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RORB gene: 
    NM_006914.3  

    Unigene Cluster for RORB:

    RAR-related orphan receptor B
    Hs.494178  [show with all ESTs]
    Unigene Representative Sequence: BX647070
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376896(uc004ajh.3) ENST00000396204(uc004aji.3)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidRORB 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB307695.1 AK313431.1 BC051830.1 BC093772.1 BC093774.1 BX647070.1 HQ709186.1 Y08639.1 

    3 DOTS entries:

    DT.438580  DT.40123208  DT.75109175 

    24/35 AceView cDNA sequences (see all 35):

    BU169404 CN482093 AI768825 NM_006914 CA397109 BQ189123 BM698896 BC051830 
    CR594193 AL118995 AL712390 AL711967 AA319114 BX647070 Y08639 BX348312 
    BM929808 AL691650 AL691651 BM669680 D61627 BG185895 F05544 CK299107 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RORB expression in normal human tissues (normalized intensities)      RORB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RORB Expression
    About this image


    RORB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 22 entries
             Thalamus
             postcentral gyrus   
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Cone Precursor Cells Outer Nuclear Layer
             Retina
             Human Non-Pigment Ciliary Epithelial Cells (HNPCEpiC)   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Hyoid Arch Muscles
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             Human Non-Pigment Ciliary Epithelial Cells (HNPCEpiC)   

    See RORB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RORB

    SOURCE GeneReport for Unigene cluster: Hs.494178
        SABiosciences Expression via Pathway-Focused PCR Arrays including RORB: 
              Circadian Rhythms in human mouse rat
              Tumor Metastasis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RORB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RORB gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rorb1 , 5 RAR-related orphan receptor beta1, 5 92.92(n)1
    98.25(a)1
      19 (13.28 cM)5
    2259981  NM_146095.41  NP_666207.31 
     189306055 
    chicken
    (Gallus gallus)
    Aves RORB1 RAR-related orphan receptor B 88.53(n)
    96.95(a)
      395980  NM_205093.1  NP_990424.1 
    lizard
    (Anolis carolinensis)
    Reptilia RORB6
    Uncharacterized protein
    97(a)
    1 ↔ 1
    2(47043636-47090177)
    zebrafish
    (Danio rerio)
    Actinopterygii rorb1 RAR-related orphan receptor B 75.09(n)
    85.71(a)
      567943  NM_001082856.1  NP_001076325.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hr461 , 3 ligand-dependent nuclear receptor3
    Hormone receptor-like in 461
    38(a)3
    49.23(n)1
    41.01(a)1
      360731  NM_176123.31  NP_788303.11 
    worm
    (Caenorhabditis elegans)
    Secernentea nhr-231 , 3 nuclear hormone receptor3
    Protein NHR-231
    75(a)3
    45.71(n)1
    37.12(a)1
      I(7228074-7228944)3
    1724601  NM_001037882.21  NP_001032971.11 


    ENSEMBL Gene Tree for RORB (if available)
    TreeFam Gene Tree for RORB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RORB gene
    RORC2  NR1D22  PPARD2  RORA2  PPARA2  NR1D12  PPARG2  
    13 SIMAP similar genes for RORB using alignment to 2 protein entries:     RORB_HUMAN (see all proteins):
    NR1F2    HNF4G    NR3C2    VDR    RORA    NR1F1
    NR5A1    PPARG    RORC    NR1I3    NR1F3    RARG
    NR1D2

    RORB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3455 SNPs in RORB are shown (see all 3455)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs43514731,2
    C,H--77110552(+) TTTGTT/CTCTTG 1 -- us2k111Minor allele frequency- C:0.01NA WA CSA EA 372
    rs1503503431,2
    C--77110607(+) CATAAC/TTTTGT 1 -- us2k10--------
    rs754239231,2
    C,F--77110845(+) CACATT/CGGTTT 1 -- us2k11Minor allele frequency- C:0.10WA 118
    rs1380124251,2
    --77111326(+) ATAAAC/TGGTCA 1 -- us2k10--------
    rs1169428921,2
    F--77111339(+) GATGAC/TAATTT 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1490830561,2
    C--77111385(+) AGTTAC/TCAATC 1 -- us2k10--------
    rs1818491001,2
    --77111450(+) CTGCAA/GTCACA 1 -- us2k10--------
    rs1860119491,2
    --77111519(+) CTGTTA/CTCCTT 1 -- us2k10--------
    rs1907237161,2
    --77111570(+) ATAAAA/TATCAA 1 -- us2k10--------
    rs1819581711,2
    --77111601(+) ATACAC/TGTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RORB (77112252 - 77302117 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for RORB (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2738557CNV Deletion23290073
    esv1321162CNV Deletion17803354
    esv2677308CNV Deletion23128226
    esv990769CNV Deletion20482838
    esv2738558CNV Deletion23290073
    esv2738559CNV Deletion23290073
    nsv517655CNV Loss19592680
    nsv6567CNV Loss18451855
    dgv487n21CNV Gain19592680
    nsv831622CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601972    OMIM disorders: --

    10 diseases for RORB:    About MalaCards
    bipolar i disorder    schizoaffective disorder    acne    retinal degeneration
    bipolar disorder    retinitis    schizophrenia    thyroiditis
    endotheliitis    neuronitis


    RORB for disorders           About GeneDecksing

    Genetic Association Database (GAD): RORB
    Human Genome Epidemiology (HuGE) Navigator: RORB (4 documents)

    Export disorders for RORB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RORB gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with RORB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence for genetic association of RORB with bipolar disorder. (PubMed id 19909500)1, 4, 9 McGrath C.L....Tsuang M.T. (2009)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    4. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. (PubMed id 19839995)1, 4 Mansour H.A....Nimgaonkar V.L. (2009)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    6. Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors. (PubMed id 7926749)1, 3 Giguere V.... Otulakowski G. (1994)
    7. All-trans retinoic acid is a ligand for the orphan nu clear receptor ROR beta. (PubMed id 12958591)1, 9 Stehlin-Gaon C....SchA1le R. (2003)
    8. X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation. (PubMed id 11689423)1, 9 Stehlin C....Renaud J.P. (2001)
    9. Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1). (PubMed id 11121580)1, 9 Gawlas K. and Stunnenberg H.G. (2000)
    10. Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells. (PubMed id 11504880)1, 9 Gawlas K. and Stunnenberg H.G. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6096 HGNC: 10259 AceView: RORB Ensembl:ENSG00000198963 euGenes: HUgn6096
    ECgene: RORB Kegg: 6096 H-InvDB: RORB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RORB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RORB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RORB gene:
    Search GeneIP for patents involving RORB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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