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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RORB Gene

protein-coding   GIFtS: 61
GCID: GC09P077112

RAR-related orphan receptor B
 Explore 9 diseases affiliated with
RORB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RORB    

Aliases
for RORB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAR-Related Orphan Receptor B1 2     RZR-BETA2
RZRB1 2 3 5     BA133M9.11
NR1F21 2 3     Nuclear Receptor ROR-Beta2
ROR-BETA1 2     RAR-Related Orphan Receptor Beta2
Nuclear Receptor RZR-Beta2 3     Retinoic Acid-Binding Receptor Beta2
Nuclear Receptor Subfamily 1 Group F Member 22 3     Retinoid-Related Orphan Receptor Beta2
Retinoid-Related Orphan Receptor-Beta2 3     

External Ids:    HGNC: 102591   Entrez Gene: 60962   Ensembl: ENSG000001989637   OMIM: 6019725   UniProtKB: Q927533   

Export aliases for RORB gene to outside databases

Previous GC identifers: GC09P068156 GC09P068968 GC09P070682 GC09P072569 GC09P074341 GC09P076302 GC09P046935


Summaries
for RORB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RORB:
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding
protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance
the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact
with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: RORB_HUMAN, Q92753
Function: Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells.
Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW
promoter (By similarity)

Gene Wiki entry for RORB (RAR-related orphan receptor beta)


Genomic Views
for RORB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RORB gene promoter:
         Egr-3   Nkx2-2   CUTL1   AREB6   PPAR-gamma1   HFH-1   IRF-7A   Cart-1   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RORB promoter sequence
   Search SABiosciences Chromatin IP Primers for RORB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RORB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q22

RORB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RORB gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P077112:  view genomic region     (about GC identifiers)

Start:
 77,112,252 bp from pter      End:
 77,302,117 bp from pter
Size:
 189,866 bases      Orientation:
 plus strand

Proteins
for RORB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RORB_HUMAN, Q92753 (See protein sequence)
Recommended Name: Nuclear receptor ROR-beta  
Size: 470 amino acids; 53220 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q8WX73
Alternative splicing: 2 isoforms:  Q92753-2   Q92753-1   

Explore the universe of human proteins at neXtProt for RORB: NX_Q92753

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92753

    • RORB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008845.2  
    ENSEMBL proteins: 
     ENSP00000366093   ENSP00000379507  
    Reactome Protein details: Q92753
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: RORB
    OriGene Protein Over-expression Lysate: RORB
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    Novus Biologicals RORB Proteins
    Novus Biologicals RORB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--


    RORB for ontologies           About GeneDecksing



    RORB Antibody Products: 
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    ThermoFisher Antibodies for RORB

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    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for RORB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RORB for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR001723 Str_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry Q92753

    ProtoNet protein and cluster: Q92753

    2 Blocks protein families:
    IPB001723 Steroid hormone receptor signature
    IPB003079 Nuclear receptor ROR family (1F nuclear receptor) signature


    UniProtKB/Swiss-Prot: RORB_HUMAN, Q92753
    Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Function
    for RORB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RORB_HUMAN, Q92753
    Function: Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells.
    Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW
    promoter (By similarity)

         Genatlas biochemistry entry for RORB:
    RAR related orphan receptor B,expressed in areas of the central nervous system,involved in the processing of sensory
    information and in the components of mammalian timing system,the suprachiasmatic nuclei,retina and pineal
    gland,steroid/thyroid retinoic receptor superfamily

    miRNA
    Products:            		 OriGene 3'-UTR Clone: RORB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RORB
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate RORB (see all 57):
    hsa-miR-3130-5p hsa-miR-520e hsa-miR-302d hsa-miR-548k hsa-miR-199a-3p hsa-miR-219-5p hsa-miR-374a hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmid: RORB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RORB (see all 4)
    OriGene shRNA RFP: RORB
    OriGene siRNA: RORB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RORB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RORB

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RORB (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RORB
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RORB (NM_006914)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RORB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RORB 

    Cell Line
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    Search LifeMap BioReagents cell lines for RORB

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RORB

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity ISS--
    GO:0003707steroid hormone receptor activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--


    RORB for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for RORB:
     Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

    Animal Models:
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rorb):
     behavior/neurological  growth/size  nervous system  reproductive system  vision/eye 

    RORB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RORB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    2Nuclear Receptor transcription pathway
    		Nuclear Receptor transcription pathway1.00
    3Circadian rhythm - mammal
    		Circadian rhythm - mammal1.00
    4Sweet Taste Signaling
    		Melatonin Signaling0.72

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RORB
        Melatonin Signaling

    3        Reactome Pathways for RORB
        Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    Gene Expression


    1         Kegg Pathway  (Kegg details for RORB):
        Circadian rhythm - mammal


    RORB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RORB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for RORB (Q927533 ENSP000003660934) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME2P223923, ENSP000003655724I2D: score=1 STRING: ENSP00000365572
    LOC100996626Q9NPJ43I2D: score=2 
    NME1P155313, ENSP000000130344I2D: score=2 STRING: ENSP00000013034
    NRIP2Q9BQI93, ENSP000003375014I2D: score=2 STRING: ENSP00000337501
    PNRC2Q9NPJ43I2D: score=2 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent TAS7935491
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007420brain development ----
    GO:0007601visual perception IEA--


    RORB for ontologies           About GeneDecksing



    Drugs & Compounds
    for RORB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RORB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RORB

    1 DrugBank Compound for RORB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MelatoninMEL (see all 4)73-31-4targetagonist7961794

    2 Novoseek chemical compound relationships for RORB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 61.5 1 12958591 (1)
    stearic acid 57.4 2 12649431 (1), 11689423 (1)

    Search CenterWatch for drugs/clinical trials and news about RORB 

    Transcripts
    for RORB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RORB gene: 
    NM_006914.3  

    Unigene Cluster for RORB:

    RAR-related orphan receptor B
    Hs.494178  [show with all ESTs]
    Unigene Representative Sequence: BX647070
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376896(uc004ajh.3) ENST00000396204(uc004aji.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: RORB
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RORB
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate RORB (see all 57):
    hsa-miR-3130-5p hsa-miR-520e hsa-miR-302d hsa-miR-548k hsa-miR-199a-3p hsa-miR-219-5p hsa-miR-374a hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmid: RORB 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RORB (see all 4)
    OriGene shRNA RFP: RORB
    OriGene siRNA: RORB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RORB
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RORB
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    GenScript: all cDNA clones in your preferred vector: RORB (NM_006914)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RORB 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RORB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RORB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RORB

    Additional cDNA sequence: 

    AB307695.1 AK313431.1 BC051830.1 BC093772.1 BC093774.1 BX647070.1 HQ709186.1 Y08639.1 

    3 DOTS entries:

    DT.438580  DT.40123208  DT.75109175 

    24/35 AceView cDNA sequences (see all 35):

    CR594193 AL118995 CA397109 AI768825 BU169404 NM_006914 BC051830 CN482093 
    BM698896 BQ189123 AL712390 BG185895 CK299107 F05544 D61627 AL691650 
    AL691651 BX348312 BM669680 AL711967 BX647070 AA319114 AA780836 Y08639 

    GeneLoc Exon Structure


    Expression
    for RORB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RORB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RORB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerCone Precursor CellsPhotoreceptors, Retina
    EyeOuter Nuclear LayerRod Precursor CellsPhotoreceptors, Retina
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    BrainHypothalamusBrain
    Neural TubeDiencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Ventral/hypothalamic-like neurons (Generation of midbra...)

    See RORB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RORB

    SOURCE GeneReport for Unigene cluster: Hs.494178
        SABiosciences Expression via Pathway-Focused PCR Arrays including RORB: 
              Circadian Rhythms in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RORB
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RORB

    Orthologs
    for RORB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RORB gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RORB1 RAR-related orphan receptor B 88.53(n)
    96.95(a)    		   395980  NM_205093.1  NP_990424.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RORB6
    		 --
    		 95(a)
    		 1 ↔ 1
    		 2(47043636-47090148)
    zebrafish
    (Danio rerio)    		 Actinopterygii rorb1 RAR-related orphan receptor B 75.09(n)
    85.71(a)    		   567943  NM_001082856.1  NP_001076325.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Hr461 , 3 ligand-dependent nuclear receptor3
    Hormone receptor-like in 461    		 38(a)3
    49.23(n)1
    41.01(a)1    		   360731  NM_176123.31  NP_788303.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea nhr-231 , 3 nuclear hormone receptor3
    Protein NHR-231    		 75(a)3
    45.71(n)1
    37.12(a)1    		   I(7228074-7228944)3
    1724601  NM_001037882.21  NP_001032971.11 


    ENSEMBL Gene Tree for RORB (if available)
    TreeFam Gene Tree for RORB (if available) 

    Paralogs
    for RORB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RORB gene
    RORC2  NR1D22  PPARD2  RORA2  NR1D12  PPARA2  PPARG2  
    13 SIMAP similar genes for RORB using alignment to 2 protein entries:     RORB_HUMAN (see all proteins):
    NR1F2    HNF4G    NR3C2    VDR    RORA    NR1F1
    NR5A1    PPARG    RORC    NR1I3    NR1F3    RARG
    NR1D2

    RORB for paralogs           About GeneDecksing



    Genomic Variants
    for RORB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2935 NCBI SNPs in RORB are shown (see all 2935)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs43514731,2
    		C,H,--77110552(+) TTTGTT/CTCTTG 1 -- us2k111Minor allele frequency- C:0.01NA WA CSA EA 372
    rs1503503431,2
    		--77110607(+) CATAAC/TTTTGT 1 -- us2k10--------
    rs754239231,2
    		C,F,--77110845(+) CACATT/CGGTTT 1 -- us2k11Minor allele frequency- C:0.10WA 118
    rs1380124251,2
    		--77111326(+) ATAAAC/TGGTCA 1 -- us2k10--------
    rs1169428921,2
    		--77111339(+) GATGAC/TAATTT 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1490830561,2
    		--77111385(+) AGTTAC/TCAATC 1 -- us2k10--------
    rs1818491001,2
    		--77111450(+) CTGCAA/GTCACA 1 -- us2k10--------
    rs1860119491,2
    		--77111519(+) CTGTTA/CTCCTT 1 -- us2k10--------
    rs1907237161,2
    		--77111570(+) ATAAAA/TATCAA 1 -- us2k10--------
    rs1819581711,2
    		--77111601(+) ATACAC/TGTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RORB (77112252 - 77302117 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for RORB
         2 CNVs: 4643 52862

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    Disorders / Diseases
    for RORB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RORB for disorders           About GeneDecksing

    OMIM gene information: 601972    OMIM disorders: --

    9 diseases for RORB:    About MalaCards
    bipolar i disorder    schizoaffective disorder    retinal degeneration    bipolar disorder
    acne    retinitis    schizophrenia    thyroiditis
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: RORB (4 documents)

    Export disorders for RORB gene to outside databases

    Publications
    for RORB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RORB gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with RORB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    2. Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors. (PubMed id 7926749)1, 3 Giguere V.... Otulakowski G. (1994)
    3. Evidence for genetic association of RORB with bipolar disorder. (PubMed id 19909500)1, 9 McGrath C.L....Tsuang M.T. (2009)
    4. All-trans retinoic acid is a ligand for the orphan nu clear receptor ROR beta. (PubMed id 12958591)1, 9 Stehlin-Gaon C....SchA1le R. (2003)
    5. X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation. (PubMed id 11689423)1, 9 Stehlin C....Renaud J.P. (2001)
    6. Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1). (PubMed id 11121580)1, 9 Gawlas K. and Stunnenberg H.G. (2000)
    7. Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells. (PubMed id 11504880)1, 9 Gawlas K. and Stunnenberg H.G. (2001)
    8. Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor. (PubMed id 10860982)1, 9 Greiner E.F....Schule R. (2000)
    9. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    10. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)

    External Searches for RORB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RORB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6096 HGNC: 10259 AceView: RORB Ensembl:ENSG00000198963 euGenes: HUgn6096
    ECgene: RORB Kegg: 6096 H-InvDB: RORB

    Other Databases showing RORB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RORB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RORB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RORB Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RORB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RORB gene:
    Search GeneIP for patents involving RORB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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