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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RORA Gene

protein-coding   GIFtS: 67
GCID: GC15M060780

RAR-Related Orphan Receptor A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAR-Related Orphan Receptor A1 2     ROR32
Nuclear Receptor RZR-Alpha2 3     RZR-ALPHA2
Nuclear Receptor Subfamily 1 Group F Member 12 3     Nuclear Receptor ROR-Alpha2
NR1F12 3     Retinoic Acid Receptor-Related Orphan Receptor Alpha2
RZRA2 3     Retinoid-Related Orphan Receptor Alpha2
ROR-alpha2     Thyroid Hormone Nuclear Receptor Alpha Variant 42
ROR12     Transcription Factor RZR-Alpha2
ROR22     Retinoid-Related Orphan Receptor-Alpha3

External Ids:    HGNC: 102581   Entrez Gene: 60952   Ensembl: ENSG000000696677   OMIM: 6008255   UniProtKB: P353983   

Export aliases for RORA gene to outside databases

Previous GC identifers: GC15M056349 GC15M053837 GC15M058368 GC15M058505 GC15M058576 GC15M037602


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RORA Gene:
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a
monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of
those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2,
a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the
product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms
have been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RORA Gene: 
RORA (RAR-related orphan receptor A) is a protein-coding gene. Diseases associated with RORA include lown-ganong-levine syndrome, and hypoalphalipoproteinemias, and among its related super-pathways are Circadian Clock and Nuclear Receptors. GO annotations related to this gene include steroid hormone receptor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is RORC.

UniProtKB/Swiss-Prot: RORA_HUMAN, P35398
Function: Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single
core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence
5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins
AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM
AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for
cholesterol or one of its derivatives

Gene Wiki entry for RORA (RAR-related orphan receptor alpha) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RORA gene promoter:
         CREB   AP-1   p300   deltaCREB   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RORA promoter sequence
   Search SABiosciences Chromatin IP Primers for RORA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RORA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.2   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q21-q22

RORA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RORA gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M060780:  view genomic region     (about GC identifiers)

Start:
60,780,483 bp from pter      End:
61,521,518 bp from pter
Size:
741,036 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RORA_HUMAN, P35398 (See protein sequence)
Recommended Name: Nuclear receptor ROR-alpha  
Size: 556 amino acids; 63036 Da
Subunit: Monomer. Interacts (via the DNA-binding domain) with HIF1; the interaction enhances HIF1A transcription
under hypoxia through increasing protein stability
Subcellular location: Nucleus
2 PDB 3D structures from and Proteopedia for RORA:
1N83 (3D)        1S0X (3D)    
Secondary accessions: P35397 P35399 P45445 Q495X4 Q96H83
Alternative splicing: 4 isoforms:  P35398-1   P35398-2   P35398-3   P35398-4   (Ref.2 (AAA02963) sequence is in conflict in position: 8:A->E)

Explore the universe of human proteins at neXtProt for RORA: NX_P35398

Explore proteomics data for RORA at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation by PKC in neurons inhibits transcriptional activity. Phosphorylated on Thr-216 by ERK2 in vitro
  • UniProtKB: Sumoylated by SENP1 and SENP2. Sumoylation, promoted by PIAS2, PIAS3, PIASy but not PIAS1, enhances the
    transcriptional activity. Desumoylated by SENP1
  • UniProtKB: Ubiquitinated. Ubiquitination is required for efficient transcriptional activity and is prevented by Hairless
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35398

  • RORA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RORA Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_002934.1  NP_599022.1  NP_599023.1  NP_599024.1  

    ENSEMBL proteins: 
     ENSP00000335087   ENSP00000309753   ENSP00000261523   ENSP00000402971   ENSP00000449482  
     ENSP00000453322  
    Reactome Protein details: P35398
    Human Recombinant Protein Products for RORA: 
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    Novus Biologicals RORA Proteins
    Novus Biologicals RORA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    RORA for ontologies           About GeneDecksing



    RORA Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: RAR-related orphan receptor-&alpha 
    1F. RAR-related orphan receptors

    5/6 InterPro protein domains (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR001723 Str_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry P35398

    ProtoNet protein and cluster: P35398

    2 Blocks protein domains:
    IPB001723 Steroid hormone receptor signature
    IPB003079 Nuclear receptor ROR family (1F nuclear receptor) signature


    UniProtKB/Swiss-Prot: RORA_HUMAN, P35398
    Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    RORA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RORA_HUMAN, P35398
    Function: Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single
    core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence
    5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins
    AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM
    AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for
    cholesterol or one of its derivatives
    Enzyme regulation: Activated by CaMK4
    Induction: By hypoxia and melatonin

         Genatlas biochemistry entry for RORA:
    RAR related orphan receptor alpha,ligand activated transcription factor no known ligand,steroid/thyroid nuclear
    receptor superfamily,interacting with EP300 and MYOD1 in myogenesis

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA17545671
    GO:0003707steroid hormone receptor activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0005515protein binding IPI14701856
         
    RORA for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Rora):
     behavior/neurological  cardiovascular system  cellular  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  muscle 
     nervous system  reproductive system  respiratory system  taste/olfaction 

    RORA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Roratm1Vgi for RORA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RORA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RORA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RORA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RORA 

    miRNA
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    8/342 QIAGEN miScript miRNA Assays for microRNAs that regulate RORA (see all 342):
    hsa-miR-124* hsa-miR-579 hsa-miR-576-3p hsa-miR-193a-3p hsa-miR-520f hsa-miR-502-3p hsa-miR-3916 hsa-miR-3162-5p
    SwitchGear 3'UTR luciferase reporter plasmidRORA 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RORA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RORA About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Circadian Clock
    Circadian Clock0.40
    Circadian Clock in Mammals0.30
    Circadian rhythm0.35
    2Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.68
    Nuclear Receptors0.68
    3Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    4Sweet Taste Signaling
    Melatonin Signaling0.72
    5Leishmaniasis
    Inflammatory bowel disease (IBD)0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RORA
        Melatonin Signaling
    Circadian Clock in Mammals

    3 BioSystems Pathways for RORA
        Adipogenesis
    Nuclear Receptors
    SIDS Susceptibility Pathways


    4        Reactome Pathways for RORA
        Circadian Clock
    Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    Gene Expression


    2         Kegg Pathways  (Kegg details for RORA):
        Circadian rhythm
    Inflammatory bowel disease (IBD)


    RORA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RORA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/75 Interacting proteins for RORA (P353981, 2, 3 ENSP000002615234) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMC5P621952, 3, ENSP000003105724MINT-2862145 I2D: score=7 STRING: ENSP00000310572
    NR0B1P518431, 2, 3, ENSP000003682534EBI-748689,EBI-946109 MINT-2855726 MINT-2856905 I2D: score=3 STRING: ENSP00000368253
    MYOD1P151723, ENSP000002500034I2D: score=2 STRING: ENSP00000250003
    NME1P155313, ENSP000000130344I2D: score=2 STRING: ENSP00000013034
    ATXN1P542533, ENSP000002447694I2D: score=1 STRING: ENSP00000244769
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006809nitric oxide biosynthetic process IEA--
    GO:0007165signal transduction NAS7926749

    RORA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RORA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RORA

    2 DrugBank Compounds for RORA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cholesterol-- 57-88-5target--17139284 17016423 10592235
    Cholesterol-Sulfate-- --target--17139284 17016423 10592235

    3 IUPHAR Ligands for RORA (RAR-related orphan receptor-&alpha)    About this table 
    LigandTypeActionAffinityPubmed IDs
    7-hydroxycholesterol
    Agonist14622968
    cholesterol sulphate
    AgonistAgonist12467577 14622968
    cholesterol
    AgonistAgonist12467577 8858107

    10/16 Novoseek inferred chemical compound relationships for RORA gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol-sulfate 73.7 7 14722075 (3), 18658046 (1), 19965867 (1)
    retinoic acid 68.7 48 12023888 (2), 20332535 (2), 19439415 (2), 15662020 (2) (see all 20)
    melatonin 64.8 39 11369450 (3), 11888668 (3), 18078443 (2), 16030176 (2) (see all 18)
    thiazolidinedione 55 4 17545671 (3), 15305379 (1)
    retinoid 46.6 3 7739535 (1), 16030176 (1), 11981035 (1)
    15-deoxy-delta-12,14-prostaglandin j2 43.1 2 15662020 (1), 16483373 (1)
    estrogen 24 3 18078443 (1), 19439415 (1), 10830318 (1)
    tyrosine 22.9 15 15654020 (2), 16211313 (1), 1334494 (1), 9684897 (1) (see all 9)
    vitamin d 16.4 1 10830318 (1)
    cholesterol 16.4 14 12467577 (3), 14722075 (2), 19786043 (1), 12467566 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about RORA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RORA gene (4 alternative transcripts): 
    NM_002943.3  NM_134260.2  NM_134261.2  NM_134262.2  

    Unigene Clusters for RORA:

    RAR-related orphan receptor A
    Hs.560343  [show with all ESTs], Hs.655155  [show with all ESTs]
    Unigene Representative Sequences: NM_134260, BC035094
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335670(uc002agt.4 uc021sni.1 uc002agv.3 uc002agw.3 uc002agx.3)
    ENST00000309157 ENST00000261523 ENST00000449337 ENST00000559587 ENST00000551975
    ENST00000560004 ENST00000559343 ENST00000558234 ENST00000557822 ENST00000559145
    ENST00000561093 ENST00000560300 ENST00000558904

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RORA

    Additional mRNA sequence: BC035094.2 

    24 DOTS entries:

    DT.100035866  DT.91758986  DT.208314  DT.311229  DT.86843853  DT.100759045  DT.100759048  DT.75102163 
    DT.95253640  DT.75168406  DT.112241  DT.65285013  DT.95365737  DT.91758984  DT.95322819  DT.121075130 
    DT.75145191  DT.91679028  DT.92032848  DT.428809  DT.75118475  DT.75137376  DT.91751329  DT.91974073 

    24/41 AceView cDNA sequences (see all 41):

    CR591459 CR611772 NM_134260 BX431840 NM_134262 U04898 U04899 BG741583 
    NM_002943 BI560917 BU619670 AL532047 BX453671 AW243356 BM553788 BG705319 
    AL700550 AL532048 BM903731 AA777459 BF308198 BX281408 AW242739 L14611 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RORA (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                -     -     -                       -                                                   
    SP2:                                      -     -     -     -           -                                                   
    SP3:                    -     -     -     -     -     -     -           -                                                   
    SP4:                                                  -     -           -                                                   
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for RORA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RORA expression in normal human tissues (normalized intensities)      RORA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGTTTGGA
    RORA Expression
    About this image


    RORA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/42 selected tissues (see all 42) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
             brain/midbrain/lateral wall   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   

    See RORA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RORA

    SOURCE GeneReport for Unigene clusters: Hs.560343 Hs.655155

    UniProtKB/Swiss-Prot: RORA_HUMAN, P35398
    Tissue specificity: Widely expressed in a number of tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including RORA: 
              Th17 Response in human mouse rat
              Circadian Rhythms in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RORA gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rora1 , 5 RAR-related orphan receptor alpha1, 5 91.01(n)1
    97.32(a)1
      9 (37.45 cM)5
    198831  NM_013646.11  NP_038674.11 
     686537865 
    chicken
    (Gallus gallus)
    Aves RORA1 RAR-related orphan receptor A 88.91(n)
    96.56(a)
      415377  XM_413763.3  XP_413763.3 
    lizard
    (Anolis carolinensis)
    Reptilia RORA6
    Uncharacterized protein
    97(a)
    1 ↔ 1
    GL343428.1(561819-567562)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc559542 similar to RAR-related orphan receptor A 73.79(n)   394042  BC051158.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hr463 ligand-dependent nuclear receptor 37(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea nhr-233 nuclear hormone receptor 33(a)   I(7228074-7228944)   --


    ENSEMBL Gene Tree for RORA (if available)
    TreeFam Gene Tree for RORA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RORA gene
    RORC2  NR1D22  PPARD2  PPARA2  NR1D12  RORB2  PPARG2  
    18/45 SIMAP similar genes for RORA using alignment to 3 protein entries:     RORA_HUMAN (see all proteins) (see all similar genes):
    NR1F1    NR1F2    RARA    NR2A3    HNF4G    VDR
    BCOR-RARA    HNF4alpha    NR3C2    NR6A1    NR1B2    NR2A1
    NR2C1    NR2C2    RARB    RORB    NR5A2    NR2B3

    RORA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/15920 SNPs in RORA are shown (see all 15920)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360624
    A colorectal cancer sample4--see VAR_0360622 P S mis40--------
    rs114015811,2
    C--37608826(+) ACTTT-/AAAAAA 4 -- ut310--------
    rs725297381,2
    C--37608833(+) AAAAA-/A/CATCCG 8 -- ut310--------
    rs675928131,2
    C--37610503(+) TCATT-/A/AA  
            
    AAAAA
    8 -- ut310--------
    rs105484931,2
    C--37610513(+) AAAAA-/AA/AAA
            
    CCATG
    8 -- ut311NA 2
    rs106538331,2
    C--37634216(+) TTCAC-/CTTA  
            
    CTTAT
    4 -- int10--------
    rs678726721,2
    C--37634218(+) TCACC-/C/CTTA
            
    TTATT
    4 -- int10--------
    rs343115041,2
    C--37635661(+) TGTCATT/-TTTTT 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs113471731,2
    C--37643780(+) CTTCT-/ATTTTT 4 -- int10--------
    rs58130311,2
    C--37652907(+) TATTA-/CCCATA 4 -- int10--------

    HapMap Linkage Disequilibrium report for RORA (60780483 - 61030483 bp, first 250kb of RORA)

    Structural Variations
         Database of Genomic Variants (DGV) 10/36 variations for RORA (see all 36):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv451e199CNV Deletion23128226
    dgv342e201CNV Deletion23290073
    esv2749760CNV Deletion23290073
    esv2749759CNV Deletion23290073
    esv2749761CNV Deletion23290073
    esv2676310CNV Deletion23128226
    esv2749757CNV Deletion23290073
    esv1376643CNV Deletion17803354
    esv2749755CNV Deletion23290073
    esv998706CNV Deletion20482838


    Human Gene Mutation Database (HGMD): RORA
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600825    OMIM disorders: --

    20/31 diseases for RORA (see all 31):    About MalaCards
    lown-ganong-levine syndrome    hypoalphalipoproteinemias    placental choriocarcinoma    pulmonary emphysema
    scoliosis    acne    major depressive disorder    choriocarcinoma
    thyroiditis    mood disorder    autism spectrum disorder    macular degeneration
    atherosclerosis    bipolar disorder    acute lymphoblastic leukemia    lymphoblastic leukemia
    asthma    prostate cancer    obesity    prostatitis


    RORA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    9 Novoseek inferred disease relationships for RORA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 25.2 10 9851961 (2), 15790933 (1), 15781255 (1), 15941850 (1) (see all 6)
    gastric cancer 19.3 1 16211313 (1)
    inflammation 4.62 4 19324970 (1), 20185965 (1), 15270719 (1), 15941850 (1)
    breast cancer 2.37 8 19439415 (3), 11369450 (2), 11888668 (1)
    cardiovascular diseases 0 4 16604183 (1), 18658046 (1)
    necrosis 0 5 15662020 (2), 18558998 (1)
    tumors 0 6 15662020 (2), 11241556 (1)
    prostate cancer 0 6 12168086 (2), 11241556 (2), 15305379 (2)
    cancer 0 2 20122401 (1), 16462772 (1)

    Genetic Association Database (GAD): RORA
    Human Genome Epidemiology (HuGE) Navigator: RORA (13 documents)

    Export disorders for RORA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RORA gene, integrated from 9 sources (see all 187):
    (articles sorted by number of sources associating them with RORA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors. (PubMed id 7926749)1, 2, 3 Giguere V.... Otulakowski G. (1994)
    2. Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling. (PubMed id 18658046)1, 2, 9 Kim E.J....Lee M.O. (2008)
    3. Identification of the human ApoAV gene as a novel RORalpha target gene. (PubMed id 15781255)1, 2, 9 Lind U.... Kang D. (2005)
    4. Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A. (PubMed id 14722075)1, 2, 9 Kallen J.... Fournier B. (2004)
    5. Convergence of linkage, gene expression and associati on data demonstrates the influence of the RAR-related orphan receptor alpha (RO RA) gene on neovascular AMD: a systems biology based approach. (PubMed id 19786043)1, 4, 9 Silveira A.C....DeAngelis M.M. (2010)
    6. SUMOylation of RORalpha potentiates transcriptional activation function. (PubMed id 19041634)1, 2, 9 Hwang E.J....Kim K.I. (2009)
    7. Transcriptional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORalpha. (PubMed id 15790933)1, 2, 9 Genoux A....Fruchart J.C. (2005)
    8. Evidence for genetic association of RORB with bipolar disorder. (PubMed id 19909500)1, 4, 9 McGrath C.L....Tsuang M.T. (2009)
    9. Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD. (PubMed id 9862959)1, 2, 9 Lau P....Muscat G.E. (1999)
    10. Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)1, 4 Imboden M....Probst-Hensch N.M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6095 HGNC: 10258 AceView: RORA Ensembl:ENSG00000069667 euGenes: HUgn6095
    ECgene: RORA Kegg: 6095 H-InvDB: RORA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RORA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RORA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RORA gene:
    Search GeneIP for patents involving RORA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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