Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ROR2 Gene

protein-coding GIFtS: 63
GCID: GC09M094325

receptor tyrosine kinase-like orphan receptor 2

(Previous symbols: NTRKR2, BDB, BDB1)

Explore 33 diseases affiliated with
ROR2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Receptor Tyrosine Kinase-Like Orphan Receptor 2¹ ²		Neurotrophic Tyrosine Kinase Receptor-Related 2²
NTRKR2¹ ² ³ ⁵		Tyrosine-Protein Kinase Transmembrane Receptor ROR2²
BDB¹ ² ⁵		EC 2.7.10.1³
BDB1¹ ² ⁵		Neurotrophic Tyrosine Kinase, Receptor-Related 2³

External Ids:	HGNC: 10257¹	Entrez Gene: 4920²	Ensembl: ENSG00000169071⁷	OMIM: 602337⁵	UniProtKB: Q01974³

Export aliases for ROR2 gene to outside databases

Previous GC identifers: GC09M085319 GC09M086212 GC09M087624 GC09M089826 GC09M091564 GC09M093365 GC09M093524 GC09M064163

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ROR2:

The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to

the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes

and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B,

a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this

gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with

generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ROR2_HUMAN, Q01974

Function: Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems

to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis

and bone formation

Gene Wiki entry for ROR2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ROR2 gene promoter:
SRF TBP HFH-3 AP-1 ATF-2 C/EBPalpha FOXI1 Chx10 c-Jun TGIF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ROR2 promoter sequence

Search SABiosciences Chromatin IP Primers for ROR2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ROR2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22 Ensembl cytogenetic band: 9q22.31 HGNC cytogenetic band: 9q22

ROR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ROR2 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M094325: view genomic region (about GC identifiers)

Start:	94,325,373 bp from pter	End:	94,712,444 bp from pter
Size:	387,072 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ROR2_HUMAN, Q01974 (See protein sequence)

Recommended Name: Tyrosine-protein kinase transmembrane receptor ROR2 precursor

Size: 943 amino acids; 104757 Da

Subunit: Homodimer; promotes osteogenesis. Binds YWHAB. Interacts with WTIP (By similarity)

Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)

Developmental stage: Expressed at high levels during early embryonic development. The expression levels drop strongly

around day 16 and there are only very low levels in adult tissues

Sequence caution: Sequence=BAD92391.1; Type=Erroneous initiation;

2 PDB 3D structures from and Proteopedia for ROR2:

3ZZW (3D)

4GT4 (3D)

Secondary accessions: Q59GF5 Q5SPI5 Q9HAY7 Q9HB61

Explore the universe of human proteins at neXtProt for ROR2: NX_Q01974

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q01974

ROR2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004551.2

ENSEMBL proteins:

ENSP00000364867 ENSP00000364860

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ROR2 Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for ROR2
	GenScript Custom Purified and Recombinant Proteins Services for ROR2
	Novus Biologicals ROR2 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ROR2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	1334494

ROR2 for ontologies About GeneDecksing

ROR2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ROR2
	R&D Systems Antibodies for ROR2
	Cell Signaling Technology (CST) Antibodies for ROR2
	OriGene Antibodies: ROR2 OriGene Custom Antibody Services for ROR2
	GenScript Custom Superior Antibodies Services for ROR2
	Novus Biologicals ROR2 Antibodies
	Abcam antibodies for ROR2
	Uscn Antibodies for ROR2
	ThermoFisher Antibodies for ROR2

Assay Products for ROR2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for ROR2 (see all)
	GenScript Custom Assay Services for ROR2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ROR2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ROR2 for domains About GeneDecksing

5/14 InterPro domains/families (see all 14):

IPR003598 Ig_sub2

IPR007110 Ig-like_dom

IPR000001 Kringle

IPR013806 Kringle-like

IPR001245 Ser-Thr/Tyr_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q01974

ProtoNet protein and cluster: Q01974

3 Blocks protein families:

IPB000001 Kringle

IPB003598 Immunoglobulin C-2 type

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: ROR2_HUMAN, Q01974

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily

Similarity: Contains 1 FZ (frizzled) domain

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 kringle domain

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ROR2_HUMAN, Q01974

Function: Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems

to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis

and bone formation

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1¹

miRNA Products:		OriGene 3'-UTR Clone: ROR2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ROR2
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ROR2 (see all 15):
		hsa-miR-623 hsa-miR-922 hsa-miR-516b* hsa-miR-548aa hsa-miR-211 hsa-miR-338-5p hsa-miR-124 hsa-miR-548t

		SwitchGear 3'UTR luciferase reporter plasmid: ROR2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ROR2 (see all 7) OriGene shRNA RFP: ROR2 OriGene siRNA: ROR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ROR2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ROR2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ROR2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ROR2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ROR2 (NM_004560)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ROR2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROR2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ROR2
		Search LifeMap BioReagents cell lines for ROR2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROR2

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004713	protein tyrosine kinase activity	--	--
GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	--
GO:0004872	receptor activity	--	--
GO:0005109	frizzled binding	IEA	--
GO:0005515	protein binding	IPI	--

ROR2 for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for ROR2:

Decreased substrate adherent c	Increased apoptosis	Increased cell death in breast	Increased mitotic index
Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-outs for ROR2: Ror2^tm1.2Meg Ror2^tm1Ymi
15/17 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Ror2) (see all 17):

adipose tissue	cardiovascular system	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	homeostasis/metabolism
limbs/digits/tail	mortality/aging	nervous system	reproductive system	respiratory system

ROR2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58	P2Y Receptor Signaling	0.38

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	1.00			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			CDC42 Pathway	0.34
	Actin Nucleation and Branching	0.66

Akt Signaling

Akt Signaling

1.00

p38 Signaling

0.60

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for ROR2

Wnt Signaling Pathway

5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ROR2 (see all 28)

	MAPK Signaling
	Paxillin Interactions
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Intracellular Calcium Signaling

1 Cell Signaling Technology (CST) Pathway for ROR2

Tyrosine Kinases / Adaptors

3 BioSystems Pathways for ROR2

	Wnt Signaling Pathway NetPath
	Noncanonical Wnt signaling pathway
	Wnt signaling network

ROR2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ROR2

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/11 Interacting proteins for ROR2 (Q01974^{1, 3} ENSP00000364860⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAGED1	Q9Y5V3³, ENSP00000364847⁴	I2D: score=3 STRING: ENSP00000364847
FZD5	Q13467³, ENSP00000354607⁴	I2D: score=1 STRING: ENSP00000354607
FZD2	Q14332³, ENSP00000323901⁴	I2D: score=3 STRING: ENSP00000323901
WNT5A	P41221³, ENSP00000264634⁴	I2D: score=2 STRING: ENSP00000264634
IKBKG	Q9Y6K9³, ENSP00000358622⁴	I2D: score=1 STRING: ENSP00000358622

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	--	--
GO:0001502	cartilage condensation	IEA	--
GO:0001756	somitogenesis	IEA	--
GO:0007165	signal transduction	TAS	1334494
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	--

ROR2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ROR2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ROR2

2 HMDB Compounds for ROR2 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

1 Novoseek chemical compound relationship for ROR2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	65.7	54	15375164 (6), 10932186 (3), 10700182 (2), 19802008 (2) (see all 25)

Search CenterWatch for drugs/clinical trials and news about ROR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ROR2 gene:

NM_004560.3

Unigene Cluster for ROR2:

Receptor tyrosine kinase-like orphan receptor 2

Hs.98255 [show with all ESTs]

Unigene Representative Sequence: AB209154

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375715(uc004ari.1) ENST00000375708(uc004arj.2 uc004ark.3)

ENST00000550066 ENST00000548585 ENST00000495386 ENST00000546883 ENST00000476440

ENST00000493846

miRNA Products:		OriGene 3'-UTR Clone: ROR2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ROR2
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ROR2 (see all 15):
		hsa-miR-623 hsa-miR-922 hsa-miR-516b* hsa-miR-548aa hsa-miR-211 hsa-miR-338-5p hsa-miR-124 hsa-miR-548t

		SwitchGear 3'UTR luciferase reporter plasmid: ROR2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ROR2 (see all 7) OriGene shRNA RFP: ROR2 OriGene siRNA: ROR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ROR2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ROR2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ROR2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ROR2 (NM_004560)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ROR2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROR2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ROR2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ROR2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ROR2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ROR2

Additional cDNA sequence:

AB209154.1 BC033697.1 BC051273.1 BC126454.1 BC130522.1 M97639.1

5 DOTS entries:

DT.451719 DT.97814488 DT.95287749 DT.315333 DT.75123731

24/79 AceView cDNA sequences (see all 79):

NM_004560 AI375643 BU631248 CK906271 BQ446244 AA256549 BM127703 AA447962

AI420252 BX342447 AI160022 BQ674791 BC051273 AA913274 BI755277 BF446336

CF242805 M97639 AA418316 BF939227 AI038785 BI089313 AI084576 AW241709

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ROR2 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	^	15
SP1:																																			-
SP2:									-		-		-		-																				-				-
SP3:					-		-		-		-		-		-																				-
SP4:					-		-		-		-		-		-																-
SP5:											-		-

ECgene alternative splicing isoforms for ROR2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ROR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ROR2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

Primitive streak-like cells (Generation of endode...)

Mesendoderm-like cells (Generation of mesend...)

Definitive endoderm-like cells (A scalable, suspensi...)

Definitive Endoderm (Generation of beta c...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ROR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ROR2

SOURCE GeneReport for Unigene cluster: Hs.98255

SABiosciences Custom PCR Arrays for ROR2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ROR2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ROR2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ROR2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ROR2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROR2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ROR2 gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ROR2¹	receptor tyrosine kinase-like orphan receptor 2	76.2(n) 87.5(a)		769516 NM_001080716.1 NP_001074185.1
lizard (Anolis carolinensis)	Reptilia	ROR2⁶	--	88(a)	1 ↔ 1	2(31726261-31753920)
African clawed frog (Xenopus laevis)	Amphibia	Xror2²	receptor tyrosine kinase Xror2	75.13(n)		AB087137.1
zebrafish (Danio rerio)	Actinopterygii	Dr.16109²	Transcribed sequence with weak similarity to protein more	78.59(n)		BI888446.1
fruit fly (Drosophila melanogaster)	Insecta	Ror³	central nervous system development transmembrane more	39(a)		31B4 --
worm (Caenorhabditis elegans)	Secernentea	cam-1¹	Protein CAM-1	45.98(n) 39.51(a)		174473 NM_001026736.3 NP_001021907.1

ENSEMBL Gene Tree for ROR2 (if available)
TreeFam Gene Tree for ROR2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ROR2 gene

INSR² ROR1² ROS1² LTK² NTRK2² IGF1R² DDR1² NTRK3²

INSRR² DDR2² MUSK² ALK² NTRK1²

13 SIMAP similar genes for ROR2 using alignment to 3 protein entries: ROR2_HUMAN (see all proteins):

ROR1 ABL1 EPHA2 FGR PLG MUSK

SRC DKFZp434L0319 tec APOA urf-ret LPAL2

FGFR3

ROR2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113891167^1,2		--	64163066(+)	`TACACC/AGGGTG`	1	--	ut3¹		1		CSA	2
rs114078962^1,2	C,F,	--	64163214(+)	`CCCAAC/AGTGGG`	1	--	ut3¹		1		WA	118
rs73654047^1,2	C,	--	64163364(+)	`ACTGCC/TTCCTC`	1	--	ut3¹		1		WA	2
rs77664658^1,2		--	64163855(+)	`GACCAC/TGTGTC`	1	--	ut3¹		0	--	--	--	--
rs76518734^1,2	F,	--	64163864(+)	`TCCTGC/TTCCCC`	1	--	ut3¹		3		CSA WA	122
rs75004227^1,2	F,	--	64163871(+)	`CCCCAG/AGACGC`	1	--	ut3¹		1		WA	118
rs76954158^1,2	C	--	64163927(+)	`CAGCT-/CTCT GTGTC`	1	--	ut3¹		0	--	--	--	--
rs73504470^1,2	C,	--	64164681(+)	`AAGGTC/TGCCCC`	2	N D	mis¹		1		WA	2
rs104894121^1,2	C	--	64164685(-)	`GCCTGA/GGGCAA`	2	* W	stg¹		0	--	--	--	--
rs104894122^1,2	C	--	64164686(-)	`AGCCTA/GGGGCA`	2	* W	stg¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ROR2 (94325373 - 94575373 bp, first 250kb of ROR2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ROR2
3 CNVs: 65455 100711 70767
1 Indel: 29210
Human Gene Mutation Database (HGMD): ROR2

Locus Specific Mutation Databases (LSDB): ROR2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ROR2

DNA2.0 Custom Variant and Variant Library Synthesis for ROR2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ROR2 for disorders           About GeneDecksing

OMIM gene information: 602337
OMIM disorders: 113000  268310
UniProtKB/Swiss-Prot: ROR2_HUMAN, Q01974

Defects in ROR2 are a cause of brachydactyly type B1 (BDB1) [MIM:113000]. BDB1 is an autosomal dominant

skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are

short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs

and big toes are usually deformed

Defects in ROR2 are a cause of Robinow syndrome autosomal recessive (RRS) [MIM:268310]. A recessive form of

Robinow syndrome, a disease characterized by short-limb dwarfism, costovertebral segmentation defects and

abnormalities of the head, face and external genitalia. The clinical signs are generally far more severe in recessive

cases, particularly skeletal abnormalities. All patients with the recessive form suffer from vertebral segmentation

abnormalities, resulting in scoliosis and chest deformities. Rib fusions are considered to be characteristic of the

autosomal recessive form. Patients can also present brachydactyly, with extensive aplasia/hypoplasia of the phalanges

and metacarpals/metatarsals, and brachy-syn-polydactyly of the hands and oligodactyly of the feet

20/33 diseases for ROR2 (see all 33): About MalaCards

robinow syndrome brachydactyly type b brachydactyly robinow syndrome, autosomal recessive

nevoid basal cell carcinoma syndrome brachydactyly, type b1 short stature basal cell carcinoma

nail dysplasia monogenic disease syndactyly renal cell carcinoma

squamous cell carcinoma dwarfism polydactyly nevus

scoliosis kidney disease carcinoma colon cancer

2 diseases from the University of Copenhagen DISEASES database for ROR2:

Brachydactyly Syndactyly

8 Novoseek disease relationships for ROR2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
brachydactyly, type b	98.4	23	17061261 (2), 19640924 (2), 10932186 (2), 19461659 (2) (see all 15)
robinow syndrome, autosomal recessive	97.5	8	19236432 (1), 15952209 (1), 17665217 (1), 19461659 (1) (see all 6)
robinow syndrome	96.3	15	17665217 (3), 17061261 (2), 19640924 (2), 18831060 (2) (see all 10)
brachydactyly	88.2	7	12919145 (1), 19236432 (1), 19640924 (1), 15952209 (1) (see all 7)
symphalangism, proximal	87.7	1	11932993 (1)
nevoid basal cell carcinoma syndrome	68.6	1	12548386 (1)
short stature	51.9	2	15952209 (1), 16446976 (1)
tumors	0	4	19561643 (1), 20185829 (1), 19448672 (1)

GeneTests: ROR2

ROR2-Related Robinow Syndrome

Human Genome Epidemiology (HuGE) Navigator: ROR2 (20 documents)

Export disorders for ROR2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ROR2 gene, integrated from 9 sources (see all 96):
(articles sorted by number of sources associating them with ROR2)

Utopia: connect your pdf to the dynamic
world of online information

Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B. (PubMed id 10700182)^{1, 2, 3, 9} Oldridge M.... Wilkie A.O.M. (2000)
A novel family of cell surface receptors with tyrosine kinase-like domain. (PubMed id 1334494)^{1, 2, 3} Masiakowski P. and Carroll R.D. (1992)
Homodimerization of Ror2 tyrosine kinase receptor induces 14-3- 3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. (PubMed id 17717073)^{1, 2, 9} Liu Y.... Billiard J. (2007)
Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. (PubMed id 10932186)^{1, 2, 9} Afzal A.R.... Jeffery S. (2000)
Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome. (PubMed id 10932187)^{1, 2, 9} van Bokhoven H.... Brunner H.G. (2000)
Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B. (PubMed id 10986040)^{1, 2, 9} Schwabe G.C....Mundlos S. (2000)
O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes. (PubMed id 14752058)^{1, 2} Medzihradszky K.F.... Burlingame A.L. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
Corrections/Erratum (PubMed id 11062486)^{1, 2} (2000)
The orphan tyrosine kinase receptor, ROR2, mediates W nt5A signaling in metastatic melanoma. (PubMed id 19802008)^{1, 9} O'Connell M.P....Weeraratna A.T. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4920	HGNC: 10257	AceView: ROR2	Ensembl:ENSG00000169071	euGenes: HUgn4920
ECgene: ROR2	H-InvDB: ROR2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ROR2	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ROR2

Intellectual Property for ROR2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ROR2 gene:
Search GeneIP for patents involving ROR2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ROR2
	Browse Small Molecules at EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Kits and Assays available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for ROR2 (ROR2)		Browse Cell Culture Products
	ELISAs for ROR2 (ROR2)		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for ROR2 (ROR2)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for ROR2		OriGene shRNA RFP for ROR2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ROR2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ROR2
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ROR2		OriGene 3'-UTR Clone for ROR2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ROR2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ROR2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for ROR2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ROR2		OriGene Custom Protein Services for ROR2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ROR2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ROR2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ROR2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ROR2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ROR2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ROR2

	GenScript Custom Purified and Recombinant Proteins Services for ROR2		GenScript cDNA clones with any tag delivered in your preferred vector for ROR2
	GenScript Custom Assay Services for ROR2		GenScript Custom Superior Antibodies Services for ROR2
	GenScript Custom overexpressing Cell Line Services for ROR2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for ROR2

	Regulatory tfbs in ROR2 promoter
	Search Chromatin IP Primers for ROR2
	RT² qPCR Primer Assay in human, mouse, rat ROR2
	GNC Network for ROR2
	SABiosciences PCR Arrays including human, mouse, rat ROR2

Search Tocris compounds for ROR2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ROR2 antibodies
	ROR2 proteins

	Antibodies for ROR2
	See all of Abcam's Antibodies, Kits and Proteins for ROR2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ROR2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ROR2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROR2

	SwitchGear 3'UTR luciferase reporter plasmids for ROR2
	SwitchGear Promoter luciferase reporter plasmids for ROR2

ThermoFisher Antibodies for ROR2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROR2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ROR2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

ROR2 Gene

receptor tyrosine kinase-like orphan receptor 2

Aliases
for ROR2 gene

Summaries
for ROR2 gene

Genomic Views
for ROR2 gene

Proteins
for ROR2 gene

Protein Domains /
Families
for ROR2 gene

Function
for ROR2 gene

Pathways & Interactions
for ROR2 gene

Drugs & Compounds
for ROR2 gene

Transcripts
for ROR2 gene

Expression
for ROR2 gene

Orthologs
for ROR2 gene

Paralogs
for ROR2 gene

Genomic Variants
for ROR2 gene

Disorders / Diseases
for ROR2 gene

Publications
for ROR2 gene

External Searches for ROR2 gene

Genome Databases showing ROR2 gene

Other Databases showing ROR2 gene

Specialized Databases showing ROR2 gene

Intellectual Property
for ROR2 gene

Products
for ROR2 gene

View Random Gene

Advanced Search

Export list of displayed genes

ROR2 Gene

receptor tyrosine kinase-like orphan receptor 2

Aliasesfor ROR2 gene

Summariesfor ROR2 gene

Genomic Viewsfor ROR2 gene

Proteinsfor ROR2 gene

Protein Domains /Familiesfor ROR2 gene

Functionfor ROR2 gene

Pathways & Interactionsfor ROR2 gene

Drugs & Compoundsfor ROR2 gene

Transcriptsfor ROR2 gene

Expression for ROR2 gene

Orthologsfor ROR2 gene

Paralogsfor ROR2 gene

Genomic Variantsfor ROR2 gene

Disorders / Diseasesfor ROR2 gene

Publicationsfor ROR2 gene

External Searches for ROR2 gene

Genome Databases showing ROR2 gene

Other Databases showing ROR2 gene

Specialized Databases showing ROR2 gene

Intellectual Propertyfor ROR2 gene

Productsfor ROR2 gene

View Random Gene

Aliases
for ROR2 gene

Summaries
for ROR2 gene

Genomic Views
for ROR2 gene

Proteins
for ROR2 gene

Protein Domains /
Families
for ROR2 gene

Function
for ROR2 gene

Pathways & Interactions
for ROR2 gene

Drugs & Compounds
for ROR2 gene

Transcripts
for ROR2 gene

Expression
for ROR2 gene

Orthologs
for ROR2 gene

Paralogs
for ROR2 gene

Genomic Variants
for ROR2 gene

Disorders / Diseases
for ROR2 gene

Publications
for ROR2 gene

Intellectual Property
for ROR2 gene

Products
for ROR2 gene