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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ROR1 Gene

protein-coding GIFtS: 61
GCID: GC01P064239

receptor tyrosine kinase-like orphan receptor 1

(Previous symbol: NTRKR1)

Explore 12 diseases affiliated with
ROR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Receptor Tyrosine Kinase-Like Orphan Receptor 1¹ ²
NTRKR1¹ ² ³ ⁵
Neurotrophic Tyrosine Kinase, Receptor-Related 1² ³
EC 2.7.10.1³ ⁸
DJ537F10.1¹
Tyrosine-Protein Kinase Transmembrane Receptor ROR1²

External Ids:	HGNC: 10256¹	Entrez Gene: 4919²	Ensembl: ENSG00000185483⁷	OMIM: 602336⁵	UniProtKB: Q01973³

Export aliases for ROR1 gene to outside databases

Previous GC identifers: GC01P064171 GC01P063159 GC01P063597 GC01P063609 GC01P063951 GC01P062347

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ROR1:

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous

system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell

surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt

signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels

in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia.

Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq, Jun

2012)

UniProtKB/Swiss-Prot: ROR1_HUMAN, Q01973

Function: Tyrosine-protein kinase receptor whose role is not yet clear

Gene Wiki entry for ROR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ROR1 gene promoter:
MyoD FOXO3 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) LCR-F1 POU3F2 FOXO3b Egr-4 FAC1 FOXO3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ROR1 promoter sequence

Search SABiosciences Chromatin IP Primers for ROR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ROR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32-p31 Ensembl cytogenetic band: 1p31.3 HGNC cytogenetic band: 1p32-p31

ROR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ROR1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P064239: view genomic region (about GC identifiers)

Start:	64,239,690 bp from pter	End:	64,647,181 bp from pter
Size:	407,492 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ROR1_HUMAN, Q01973 (See protein sequence)

Recommended Name: Tyrosine-protein kinase transmembrane receptor ROR1 precursor

Size: 937 amino acids; 104283 Da

Subcellular location: Membrane; Single-pass type I membrane protein

Developmental stage: Expressed at high levels during early embryonic development. The expression levels drop strongly

around day 16 and there are only very low levels in adult tissues

Secondary accessions: Q5VVX6 Q66K77 Q92776

Alternative splicing: 3 isoforms: Q01973-1 Q01973-2 Q01973-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ROR1: NX_Q01973

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q01973

2 DME Specific Peptides for ROR1 (Q01973)

GVVLWEI

GLQPYYG

ROR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001077061.1 NP_005003.2

ENSEMBL proteins:

ENSP00000360121 ENSP00000360120 ENSP00000441637

Human Recombinant Protein Products:

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	Novus Biologicals ROR1 Protein Novus Biologicals ROR1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ROR1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	8875995
GO:0005886	plasma membrane	TAS	8875995
GO:0005887	integral to plasma membrane	TAS	1334494

ROR1 for ontologies About GeneDecksing

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Assay Products for ROR1:

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	Uscn ELISAs and CLIAs for ROR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ROR1 for domains About GeneDecksing

5/14 InterPro domains/families (see all 14):

IPR003598 Ig_sub2

IPR007110 Ig-like_dom

IPR000001 Kringle

IPR013806 Kringle-like

IPR001245 Ser-Thr/Tyr_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q01973

ProtoNet protein and cluster: Q01973

3 Blocks protein families:

IPB000001 Kringle

IPB003598 Immunoglobulin C-2 type

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: ROR1_HUMAN, Q01973

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily

Similarity: Contains 1 FZ (frizzled) domain

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 kringle domain

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ROR1_HUMAN, Q01973

Function: Tyrosine-protein kinase receptor whose role is not yet clear

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Genatlas biochemistry entry for ROR1:

receptor tyrosine kinase-like orphan receptor 1,with strong homology to the tyrosine kinase domain of growth

factor-receptors (TRK),RTK superfamily

Enzyme Number (IUBMB): EC 2.7.10.1¹ ²

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ROR1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ROR1
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate ROR1:
		hsa-miR-513a-5p hsa-miR-27a hsa-miR-654-3p hsa-miR-27b
		SwitchGear 3'UTR luciferase reporter plasmid: ROR1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ROR1 (see all 6) OriGene siRNA: ROR1
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ROR1

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ROR1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ROR1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ROR1 (NM_005012)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ROR1
		Search LifeMap BioReagents cell lines for ROR1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROR1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--
GO:0017147	Wnt-protein binding	IPI	18287027

ROR1 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for ROR1:

Decreased substrate adherent c

Increased Salmonella enterica

Increased apoptosis

Animal Models:
Mouse knock-out Ror1^tm1.2Meg for ROR1
9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ror1):

cardiovascular system	craniofacial	embryogenesis	homeostasis/metabolism	limbs/digits/tail
mortality/aging	nervous system	respiratory system	skeleton

ROR1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58	P2Y Receptor Signaling	0.38

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	1.00			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			CDC42 Pathway	0.34
	Actin Nucleation and Branching	0.66

Akt Signaling

Akt Signaling

1.00

p38 Signaling

0.60

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for ROR1

Wnt Signaling Pathway

5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ROR1 (see all 28)

	MAPK Signaling
	Paxillin Interactions
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Intracellular Calcium Signaling

1 Cell Signaling Technology (CST) Pathway for ROR1

Tyrosine Kinases / Adaptors

1 BioSystems Pathway for ROR1

Nuclear Receptors

ROR1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ROR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/8 Interacting proteins for ROR1 (Q01973^{1, 3} ENSP00000360120⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAGED1	Q9Y5V3³, ENSP00000364847⁴	I2D: score=1 STRING: ENSP00000364847
EGFR	P00533¹, ENSP00000275493⁴	EBI-6082337,EBI-297353 STRING: ENSP00000275493
SRC	P12931¹, ENSP00000350941⁴	EBI-6082337,EBI-1383910 STRING: ENSP00000350941
NGF	ENSP00000358525⁴	STRING: ENSP00000358525
WNT5A	ENSP00000264634⁴	STRING: ENSP00000264634

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	--

ROR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ROR1

2 HMDB Compounds for ROR1 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

Search CenterWatch for drugs/clinical trials and news about ROR1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ROR1 gene (2 alternative transcripts):

NM_001083592.1 NM_005012.3

Unigene Cluster for ROR1:

Receptor tyrosine kinase-like orphan receptor 1

Hs.128753 [show with all ESTs]

Unigene Representative Sequence: NM_005012

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000371080(uc001dbi.4) ENST00000371079(uc001dbj.2) ENST00000482426

ENST00000545203

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ROR1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ROR1
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate ROR1:
		hsa-miR-513a-5p hsa-miR-27a hsa-miR-654-3p hsa-miR-27b
		SwitchGear 3'UTR luciferase reporter plasmid: ROR1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ROR1 (see all 6) OriGene siRNA: ROR1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ROR1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ROR1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ROR1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ROR1 (NM_005012)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ROR1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ROR1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ROR1

Additional cDNA sequence:

AK000776.1 AK308088.1 AK309189.1 BC006374.1 BC080541.1 BC128386.1 M97675.1

5 DOTS entries:

DT.420292 DT.307611 DT.100883342 DT.95253870 DT.95086541

24/48 AceView cDNA sequences (see all 48):

BQ929090 BQ029965 BX380726 BU726642 CA446148 CD678450 BQ694615 BX488030

F04103 M97675 BF700200 BF305859 BU543285 AV727772 BC006374 BI544641

NM_005012 BG419754 BF570316 BQ681228 BC080541 F07847 BX283151 BG328899

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ROR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGCTTATA

About this image

ROR1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ROR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ROR1

SOURCE GeneReport for Unigene cluster: Hs.128753

UniProtKB/Swiss-Prot: ROR1_HUMAN, Q01973

Tissue specificity: Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is

strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or

PNS neuroectoderm

SABiosciences Custom PCR Arrays for ROR1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ROR1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ROR1 gene from 4/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ROR1¹	receptor tyrosine kinase-like orphan receptor 1	81.25(n) 92.99(a)		395179 NM_204509.1 NP_989840.1
lizard (Anolis carolinensis)	Reptilia	ROR1⁶	--	93(a)	1 ↔ 1	4(98856403-98909718)
zebrafish (Danio rerio)	Actinopterygii	ror1¹	receptor tyrosine kinase-like orphan receptor 1	70.27(n) 76.2(a)		568282 XM_691603.5 XP_696695.4
fruit fly (Drosophila melanogaster)	Insecta	Ror^{1 , 3}	central nervous system development transmembrane receptor protein tyrosine kinase less³ CG4926-PA¹	42(a)³ 51.37(n)¹ 48.77(a)¹		31B4³ 34367¹ NM_057614.2¹ NP_476962.1¹

ENSEMBL Gene Tree for ROR1 (if available)
TreeFam Gene Tree for ROR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ROR1 gene

INSR² ROS1² LTK² NTRK2² IGF1R² DDR1² NTRK3² ROR2²

INSRR² DDR2² MUSK² ALK² NTRK1²

18/25 SIMAP similar genes for ROR1 using alignment to 2 protein entries: ROR1_HUMAN (see all proteins) (see all similar genes):

RET ROR2 ABL1 EPHA2 BTK kinase deficient isoform 6 SRC

DKFZp434L0319 BTK FES tec FGFR2 FGR

DKFZp686M05208 LPAL2 PLG DKFZp686I03148 RYK urf-ret

ROR1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72926694^1,2	C,F,	--	62345781(+)	`TAGATC/TTCAGG`	2	--	us2k¹		3		WA	122
rs76154781^1,2		--	62346211(+)	`CATTCC/TAGGTA`	2	--	us2k¹		1		WA	118
rs76448441^1,2	F,	--	62346240(+)	`ATACCT/CAGATG`	2	--	us2k¹		1		WA	118
rs113754220^1,2		--	62346462(+)	`TTTCCC/TTTTGA`	2	--	us2k¹		1		CSA	2
rs11809686^1,2	C,F,H	--	62347351(+)	`ttctgG/Tcaagt`	2	--	us2k¹		1		NA	4
rs75390249^1,2	C,	--	62347597(+)	`CGAGAA/GAGGGA`	2	--	ut5¹		0	--	--	--	--
rs12755085^1,2	C	--	62348041(+)	`GCCGCG/TCTGCT`	4	A	syn¹ ese³		0	--	--	--	--
rs606550^1,2	C,	--	62348136(+)	`TTCCGT/CCGTCC`	2	--	int¹		2		MN NA	186
rs608254^1,2		--	62348481(+)	`GAGCCG/CGCCCG`	2	--	int¹		4		MN NA	308
rs620019^1,2	C,F,O,H,	--	62348825(+)	`ATCTCT/CAAAGA`	2	--	int¹		16		MN NS EA NA	2286

HapMap Linkage Disequilibrium report for ROR1 (64239690 - 64489690 bp, first 250kb of ROR1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ROR1
1 Indel: 59932

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ROR1

DNA2.0 Custom Variant and Variant Library Synthesis for ROR1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ROR1 for disorders           About GeneDecksing

OMIM gene information: 602336    OMIM disorders: --

12 diseases for ROR1:    About MalaCards

acute lymphoblastic leukemia chronic lymphocytic leukemia lymphoblastic leukemia lymphocytic leukemia

brachydactyly wilms tumor bipolar disorder leukemia

neuronitis breast cancer adenocarcinoma pancreatitis

Human Genome Epidemiology (HuGE) Navigator: ROR1 (15 documents)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ROR1 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with ROR1)

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Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains. (PubMed id 8875995)^{1, 2, 3, 9} Reddy U.R.... Pleasure D. (1996)
A novel family of cell surface receptors with tyrosine kinase-like domain. (PubMed id 1334494)^{1, 2, 3} Masiakowski P. and Carroll R.D. (1992)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy. (PubMed id 18546292)^{1, 9} Daneshmanesh A.H....Rabbani H. (2008)
Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis. (PubMed id 9143508)^{1, 9} Reddy U.R....Biegel J.A. (1997)
Detection of orphan receptor tyrosine kinase (ROR-1) e xpression in Egyptian pediatric acute lymphoblastic leukemia. (PubMed id 22369092)¹ Shaheen I. and Ibrahim N. (2012)
Crosstalk between ROR1 and the Pre-B cell receptor pro motes survival of t(1;19) acute lymphoblastic leukemia. (PubMed id 23153538)¹ Bicocca V.T....Tyner J.W. (2012)
ROR1 is expressed in human breast cancer and associate d with enhanced tumor-cell growth. (PubMed id 22403610)¹ Zhang S....Kipps T.J. (2012)
ROR1 is expressed on hematogones (non-neoplastic huma n B-lymphocyte precursors) and a minority of precursor-B acute lymphoblastic le ukemia. (PubMed id 21813176)¹ Broome H.E....Kipps T.J. (2011)
Cytoskeleton network and cellular migration modulated by nuclear-localized receptor tyrosine kinase ROR1. (PubMed id 22199287)¹ Tseng H.C....Lin W.C. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4919	HGNC: 10256	AceView: ROR1	Ensembl:ENSG00000185483	euGenes: HUgn4919
ECgene: ROR1	H-InvDB: ROR1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ROR1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ROR1 gene
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receptor tyrosine kinase-like orphan receptor 1

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receptor tyrosine kinase-like orphan receptor 1

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