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Aliases for ROR1 Gene

Aliases for ROR1 Gene

  • Receptor Tyrosine Kinase-Like Orphan Receptor 1 2 3 5
  • Neurotrophic Tyrosine Kinase, Receptor-Related 1 3 4
  • NTRKR1 3 4
  • EC 2.7.10.1 63
  • DJ537F10.1 3

External Ids for ROR1 Gene

Previous HGNC Symbols for ROR1 Gene

  • NTRKR1

Previous GeneCards Identifiers for ROR1 Gene

  • GC01P064171
  • GC01P063159
  • GC01P063597
  • GC01P063609
  • GC01P063951
  • GC01P062347
  • GC01P064239

Summaries for ROR1 Gene

Entrez Gene Summary for ROR1 Gene

  • This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for ROR1 Gene

ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ALK.

UniProtKB/Swiss-Prot for ROR1 Gene

  • Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.

Gene Wiki entry for ROR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROR1 Gene

Genomics for ROR1 Gene

Regulatory Elements for ROR1 Gene

Promoters for ROR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ROR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ROR1 Gene

Chromosome:
1
Start:
63,774,019 bp from pter
End:
64,181,498 bp from pter
Size:
407,480 bases
Orientation:
Plus strand

Genomic View for ROR1 Gene

Genes around ROR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ROR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ROR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROR1 Gene

Proteins for ROR1 Gene

  • Protein details for ROR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01973-ROR1_HUMAN
    Recommended name:
    Inactive tyrosine-protein kinase transmembrane receptor ROR1
    Protein Accession:
    Q01973
    Secondary Accessions:
    • Q5VVX6
    • Q66K77
    • Q92776

    Protein attributes for ROR1 Gene

    Size:
    937 amino acids
    Molecular mass:
    104283 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ROR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ROR1 Gene

Proteomics data for ROR1 Gene at MOPED

Selected DME Specific Peptides for ROR1 Gene

Post-translational modifications for ROR1 Gene

  • Glycosylation at Asn 47, Asn 66, Asn 184, and Asn 315
  • Modification sites at PhosphoSitePlus

Other Protein References for ROR1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ROR1 (ROR1)

Domains & Families for ROR1 Gene

Suggested Antigen Peptide Sequences for ROR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q01973

UniProtKB/Swiss-Prot:

ROR1_HUMAN :
  • Contains 1 FZ (frizzled) domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
Domain:
  • Contains 1 FZ (frizzled) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 kringle domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
genes like me logo Genes that share domains with ROR1: view

Function for ROR1 Gene

Molecular function for ROR1 Gene

GENATLAS Biochemistry:
receptor tyrosine kinase-like orphan receptor 1,with strong homology to the tyrosine kinase domain of growth factor-receptors (TRK),RTK superfamily
UniProtKB/Swiss-Prot Function:
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.

Enzyme Numbers (IUBMB) for ROR1 Gene

Gene Ontology (GO) - Molecular Function for ROR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 22439932
GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway TAS 24431302
genes like me logo Genes that share ontologies with ROR1: view
genes like me logo Genes that share phenotypes with ROR1: view

Animal Models for ROR1 Gene

MGI Knock Outs for ROR1:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ROR1 Gene

Localization for ROR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ROR1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ROR1 Gene COMPARTMENTS Subcellular localization image for ROR1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ROR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8875995
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ROR1: view

Pathways & Interactions for ROR1 Gene

genes like me logo Genes that share pathways with ROR1: view

SIGNOR curated interactions for ROR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ROR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA,TAS 8875995
genes like me logo Genes that share ontologies with ROR1: view

Drugs & Compounds for ROR1 Gene

(1) Drugs for ROR1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for ROR1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ROR1: view

Transcripts for ROR1 Gene

Unigene Clusters for ROR1 Gene

Receptor tyrosine kinase-like orphan receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ROR1 Gene

No ASD Table

Relevant External Links for ROR1 Gene

GeneLoc Exon Structure for
ROR1
ECgene alternative splicing isoforms for
ROR1

Expression for ROR1 Gene

mRNA expression in normal human tissues for ROR1 Gene

mRNA differential expression in normal tissues according to GTEx for ROR1 Gene

This gene is overexpressed in Artery - Tibial (x5.4).

Protein differential expression in normal tissues from HIPED for ROR1 Gene

This gene is overexpressed in Serum (34.5) and Synovial fluid (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ROR1 Gene



SOURCE GeneReport for Unigene cluster for ROR1 Gene Hs.128753

mRNA Expression by UniProt/SwissProt for ROR1 Gene

Q01973-ROR1_HUMAN
Tissue specificity: Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.
genes like me logo Genes that share expression patterns with ROR1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ROR1 Gene

Orthologs for ROR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ROR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ROR1 35
  • 93.06 (n)
  • 98.03 (a)
ROR1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ROR1 35
  • 91.56 (n)
  • 97.92 (a)
ROR1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ror1 35
  • 89.1 (n)
  • 96.92 (a)
Ror1 16
Ror1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ROR1 35
  • 99.52 (n)
  • 100 (a)
ROR1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ror1 35
  • 88.36 (n)
  • 96.7 (a)
oppossum
(Monodelphis domestica)
Mammalia ROR1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ROR1 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ROR1 35
  • 81.25 (n)
  • 92.99 (a)
ROR1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ROR1 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ror1 35
  • 77.45 (n)
  • 88.08 (a)
zebrafish
(Danio rerio)
Actinopterygii ror1 35
  • 70.28 (n)
  • 76.46 (a)
ror1 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ror 37
  • 42 (a)
Ror 35
  • 51.53 (n)
  • 49.47 (a)
Ror 36
  • 37 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006219 35
  • 53.71 (n)
  • 50.36 (a)
worm
(Caenorhabditis elegans)
Secernentea cam-1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13123 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
Species with no ortholog for ROR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ROR1 Gene

ENSEMBL:
Gene Tree for ROR1 (if available)
TreeFam:
Gene Tree for ROR1 (if available)

Paralogs for ROR1 Gene

Paralogs for ROR1 Gene

genes like me logo Genes that share paralogs with ROR1: view

Variants for ROR1 Gene

Sequence variations from dbSNP and Humsavar for ROR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035713 A breast cancer sample
VAR_041779 A metastatic melanoma sample
VAR_041780 An ovarian mucinous carcinoma sample
VAR_041781 A renal clear cell carcinoma sample
rs7527017 - 64,177,594(+) ATGGA(A/C/T)GGAAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ROR1 Gene

Variant ID Type Subtype PubMed ID
esv8740 CNV Gain 19470904
nsv830037 CNV Gain 17160897
nsv871828 CNV Gain 21882294
esv2664106 CNV Deletion 23128226
nsv1154 CNV Loss 18451855
nsv823087 CNV Loss 20364138
esv2749085 CNV Deletion 23290073
esv2676273 CNV Deletion 23128226
esv273965 CNV Insertion 20981092
esv269636 CNV Insertion 20981092
esv993189 CNV Deletion 20482838
nsv871805 CNV Loss 21882294

Variation tolerance for ROR1 Gene

Residual Variation Intolerance Score: 9.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.73; 89.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ROR1 Gene

HapMap Linkage Disequilibrium report
ROR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROR1 Gene

Disorders for ROR1 Gene

Relevant External Links for ROR1

Genetic Association Database (GAD)
ROR1
Human Genome Epidemiology (HuGE) Navigator
ROR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ROR1

No disorders were found for ROR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ROR1 Gene

Publications for ROR1 Gene

  1. Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains. (PMID: 8875995) Reddy U.R. … Pleasure D. (Oncogene 1996) 2 3 4 23 67
  2. Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy. (PMID: 18546292) Daneshmanesh A.H. … Rabbani H. (Int. J. Cancer 2008) 3 23
  3. Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis. (PMID: 9143508) Reddy U.R. … Biegel J.A. (Genomics 1997) 3 23
  4. A novel family of cell surface receptors with tyrosine kinase-like domain. (PMID: 1334494) Masiakowski P. … Carroll R.D. (J. Biol. Chem. 1992) 2 3
  5. ROR1 can interact with TCL1 and enhance leukemogenesis in EI1-TCL1 transgenic mice. (PMID: 24379361) Widhopf G.F. … Kipps T.J. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for ROR1 Gene

Sources for ROR1 Gene

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