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ROR1 Gene

protein-coding   GIFtS: 67
GCID: GC01P064239

Receptor Tyrosine Kinase-Like Orphan Receptor 1


(Previous symbol: NTRKR1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Receptor Tyrosine Kinase-Like Orphan Receptor 11 2
NTRKR11 2 3 5
Neurotrophic Tyrosine Kinase, Receptor-Related 12 3
EC 2.7.10.13 8
dJ537F10.12
Tyrosine-Protein Kinase Transmembrane Receptor ROR12

External Ids:    HGNC: 102561   Entrez Gene: 49192   Ensembl: ENSG000001854837   OMIM: 6023365   UniProtKB: Q019733   

Export aliases for ROR1 gene to outside databases

Previous GC identifers: GC01P064171 GC01P063159 GC01P063597 GC01P063609 GC01P063951 GC01P062347


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ROR1 Gene:
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central
nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily
of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the
non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but
expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell
chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different
isoforms. (provided by RefSeq, Jun 2012)

GeneCards Summary for ROR1 Gene:
ROR1 (receptor tyrosine kinase-like orphan receptor 1) is a protein-coding gene. GO annotations related to this gene include Wnt-protein binding and transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is INSR.

UniProtKB/Swiss-Prot: ROR1_HUMAN, Q01973
Function: Tyrosine-protein kinase receptor whose role is not yet clear

Gene Wiki entry for ROR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the ROR1 gene promoter:
         MyoD   FOXO3   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   LCR-F1   POU3F2   FOXO3b   Egr-4   FAC1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidROR1 promoter sequence
   Search Chromatin IP Primers for ROR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ROR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32-p31   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p32-p31

ROR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ROR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P064239:  view genomic region     (about GC identifiers)

Start:
64,239,690 bp from pter      End:
64,647,181 bp from pter
Size:
407,492 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ROR1_HUMAN, Q01973 (See protein sequence)
Recommended Name: Tyrosine-protein kinase transmembrane receptor ROR1 precursor  
Size: 937 amino acids; 104283 Da
Developmental stage: Expressed at high levels during early embryonic development. The expression levels drop
strongly around day 16 and there are only very low levels in adult tissues
Secondary accessions: Q5VVX6 Q66K77 Q92776
Alternative splicing: 3 isoforms:  Q01973-1   Q01973-2   Q01973-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ROR1: NX_Q01973

Explore proteomics data for ROR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn47, Asn66, Asn184, Asn315
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for ROR1 (Q01973)
     GVVLWEI  GLQPYYG 


    See ROR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001077061.1  NP_005003.2  

    ENSEMBL proteins: 
     ENSP00000360121   ENSP00000360120   ENSP00000441637  
    Reactome Protein details: Q01973

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: receptor tyrosine kinase-like orphan receptor 1
    Ror family
    ROR family and other RTKs

    Selected InterPro protein domains (see all 14):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR000001 Kringle
     IPR013806 Kringle-like
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q01973

    ProtoNet protein and cluster: Q01973

    3 Blocks protein domains:
    IPB000001 Kringle
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: ROR1_HUMAN, Q01973
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily
    Similarity: Contains 1 FZ (frizzled) domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 kringle domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with ROR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ROR1_HUMAN, Q01973
    Function: Tyrosine-protein kinase receptor whose role is not yet clear
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for ROR1:
    receptor tyrosine kinase-like orphan receptor 1,with strong homology to the tyrosine kinase domain of growth
    factor-receptors (TRK),RTK superfamily

         Enzyme Number (IUBMB): EC 2.7.10.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with ROR1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ROR1:
     Decreased substrate adherent c  Increased Salmonella enterica   Increased apoptosis 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ror1):
     cardiovascular system  craniofacial  embryogenesis  homeostasis/metabolism  limbs/digits/tail 
     mortality/aging  nervous system  respiratory system  skeleton 

    Find genes that share phenotypes with ROR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ror1tm1.2Meg for ROR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ROR1
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    miRNA
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    miRTarBase miRNAs that target ROR1:
    hsa-mir-124-3p (MIRT022495), hsa-mir-7-5p (MIRT025759), hsa-mir-19b-3p (MIRT031179), hsa-mir-98-5p (MIRT027572)

    Block miRNA regulation of human, mouse, rat ROR1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ROR1:
    hsa-miR-513a-5p hsa-miR-27a hsa-miR-654-3p hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidROR1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ROR1_HUMAN, Q01973: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8875995
    GO:0005886plasma membrane TAS1334494
    GO:0005887integral component of plasma membrane TAS1334494
    GO:0043235receptor complex IDA--

    Find genes that share ontologies with ROR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ROR1 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    5beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Signaling by Wnt0.79


    Find genes that share SuperPaths with ROR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ROR1
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ROR1 (see all 28)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for ROR1
        Tyrosine Kinases / Adaptors

    1 BioSystems Pathway for ROR1
        Nuclear Receptors


    1 Reactome Pathway for ROR1
        WNT5A-dependent internalization of FZD2, FZD5 and ROR2


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ROR1
    Interactions:

        Search GeneGlobe Interaction Network for ROR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for ROR1 (Q019731, 3 ENSP000003601204) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGED1Q9Y5V33, ENSP000003648474I2D: score=1 STRING: ENSP00000364847
    EGFRP005331, ENSP000002754934EBI-6082337,EBI-297353 STRING: ENSP00000275493
    SRCP129311, ENSP000003509414EBI-6082337,EBI-621482 STRING: ENSP00000350941
    NGFENSP000003585254STRING: ENSP00000358525
    WNT5AENSP000002646344STRING: ENSP00000264634
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--
    GO:0018108peptidyl-tyrosine phosphorylation TAS8875995

    Find genes that share ontologies with ROR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ROR1

    2 HMDB Compounds for ROR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ROR1 gene (2 alternative transcripts): 
    NM_001083592.1  NM_005012.3  

    Unigene Cluster for ROR1:

    Receptor tyrosine kinase-like orphan receptor 1
    Hs.128753  [show with all ESTs]
    Unigene Representative Sequence: NM_005012
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371080(uc001dbi.4) ENST00000371079(uc001dbj.2) ENST00000482426
    ENST00000545203
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    Additional mRNA sequence: 

    AK000776.1 AK308088.1 AK309189.1 BC006374.1 BC080541.1 BC128386.1 M97675.1 

    5 DOTS entries:

    DT.420292  DT.307611  DT.100883342  DT.95253870  DT.95086541 

    Selected AceView cDNA sequences (see all 48):

    BX488030 BQ929090 BQ029965 CA446148 BU726642 BX380726 F04103 CD678450 
    BQ694615 BF305859 BF700200 AV727772 BU543285 BI544641 NM_005012 BG419754 
    BF570316 BQ681228 M97675 BC080541 BX283151 F07847 BC006374 BG328899 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ROR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCTTATA
    ROR1 Expression
    About this image


    ROR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 3 entries
             Inner Enamel Epithelial Cells Dental Enamel
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Small Pre B-Cells Hematopoietic Bone Marrow
             Umbilical cord blood-derived mesenchymal stem cells
     
     Epithelial Cells
             Inner Enamel Epithelial Cells Dental Enamel
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
    ROR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ROR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128753

    UniProtKB/Swiss-Prot: ROR1_HUMAN, Q01973
    Tissue specificity: Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is
    strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS
    or PNS neuroectoderm

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ROR1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ror11 , 5 receptor tyrosine kinase-like orphan receptor 11, 5 89.1(n)1
    96.92(a)1
      4 (45.71 cM)5
    265631  NM_013845.41  NP_038873.21 
     1000957915 
    chicken
    (Gallus gallus)
    Aves ROR11 receptor tyrosine kinase-like orphan receptor 1 81.25(n)
    92.99(a)
      395179  NM_204509.1  NP_989840.1 
    lizard
    (Anolis carolinensis)
    Reptilia ROR16
    receptor tyrosine kinase-like orphan receptor 1
    89(a)
    1 ↔ 1
    4(98856403-99091284)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ror11 receptor tyrosine kinase-like orphan receptor 1 77.45(n)
    88.08(a)
      100498561  XM_002931613.2  XP_002931659.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ror11 receptor tyrosine kinase-like orphan receptor 1 70.28(n)
    76.46(a)
      568282  XM_005165885.1  XP_005165942.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ror1 , 3 central nervous system development
    transmembrane more3
    Ror1
    42(a)3
    51.53(n)1
    49.47(a)1
      31B43
    343671  NM_057614.31  NP_476962.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cam-16
    Protein CAM-1, isoform a
    28(a)
    1 → many
    II(9295937-9310301) WBGene00000289


    ENSEMBL Gene Tree for ROR1 (if available)
    TreeFam Gene Tree for ROR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ROR1 gene
    INSR2  ROS12  NTRK22  LTK2  IGF1R2  DDR12  NTRK32  INSRR2  
    ROR22  DDR22  MUSK2  ALK2  NTRK12  
    Selected SIMAP similar genes for ROR1 using alignment to 2 protein entries:     ROR1_HUMAN (see all proteins) (see all similar genes):
    RET    ROR2    ABL1    EPHA2    BTK kinase deficient isoform 6    SRC
    DKFZp434L0319    BTK    FES    tec    FGFR2    FGR
    DKFZp686M05208    LPAL2    PLG    DKFZp686I03148    RYK    urf-ret

    Find genes that share paralogs with ROR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ROR1 (see all 7642)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0417864
    A colorectal adenocarcinoma sample4--see VAR_0417862 S N mis40--------
    VAR_0417834
    A colorectal adenocarcinoma sample4--see VAR_0417832 R I mis40--------
    VAR_0417804
    An ovarian mucinous carcinoma sample4--see VAR_0417802 F L mis40--------
    VAR_0417814
    A renal clear cell carcinoma sample4--see VAR_0417812 I V mis40--------
    VAR_0417794
    A metastatic melanoma sample4--see VAR_0417792 G E mis40--------
    VAR_0357134
    A breast cancer sample4--see VAR_0357132 E D mis40--------
    rs1828130121,2
    --62356112(+) GAGGTG/TTTTTT 2 -- int10--------
    rs722973651,2
    C--62361006(+) TTCCT-/TCCT/TTCCTTCCTT
    CCTTCCTTCCTTCCTTCC
    GCCTT
    2 -- int10--------
    rs113927191,2
    C--62366345(+) AACTT-/AACTTA 2 -- int10--------
    rs113216761,2
    C,F--62452031(+) AGTGAT/-TTTTT 2 -- int1 trp33Minor allele frequency- -:0.50NA CSA 6

    HapMap Linkage Disequilibrium report for ROR1 (64239690 - 64489690 bp, first 250kb of ROR1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ROR1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676273CNV Deletion23128226
    esv2664106CNV Deletion23128226
    esv993189CNV Deletion20482838
    esv2749085CNV Deletion23290073
    esv269636CNV Insertion20981092
    esv273965CNV Insertion20981092
    nsv823087CNV Loss20364138
    nsv1154CNV Loss18451855
    nsv871805CNV Loss21882294
    nsv871828CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ROR1
    DNA2.0 Custom Variant and Variant Library Synthesis for ROR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602336    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ROR1:
    Chronic lymphocytic leukemia

    Find genes that share disorders with ROR1           About GenesLikeMe

    Genetic Association Database (GAD): ROR1
    Human Genome Epidemiology (HuGE) Navigator: ROR1 (15 documents)

    Export disorders for ROR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ROR1 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with ROR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains. (PubMed id 8875995)1, 2, 3, 9 Reddy U.R.... Pleasure D. (Oncogene 1996)
    2. A novel family of cell surface receptors with tyrosine kinase-like domain. (PubMed id 1334494)1, 2, 3 Masiakowski P. and Carroll R.D. (J. Biol. Chem. 1992)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Genome-wide association study of bipolar disorder in European American and African American individuals. (PubMed id 19488044)1, 4 Smith E.N....Kelsoe J.R. (Mol. Psychiatry 2009)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy. (PubMed id 18546292)1, 9 Daneshmanesh A.H....Rabbani H. (Int. J. Cancer 2008)
    9. Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis. (PubMed id 9143508)1, 9 Reddy U.R....Biegel J.A. (Genomics 1997)
    10. ROR1 can interact with TCL1 and enhance leukemogenesis in EI1-TCL1 transgenic mice. (PubMed id 24379361)1 Widhopf G.F....Kipps T.J. (Proc. Natl. Acad. Sci. U.S.A. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4919 HGNC: 10256 AceView: ROR1 Ensembl:ENSG00000185483 euGenes: HUgn4919
    ECgene: ROR1 H-InvDB: ROR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ROR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ROR1 gene:
    Search GeneIP for patents involving ROR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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