ROPN1L Gene
protein-coding GIFtS : 50
GCID: GC05 P010441
rhophilin associated tail protein 1-like (Previous name: ropporin 1-like )
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Aliasesfor ROPN1L gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Rhophilin Associated Tail Protein 1-Like 1 2 ROPN1-Like Protein2 3 ASP1 2 3 5 FLJ257761 RSPH111 2 Radial Spoke Head 11 Homolog2 Ropporin 1-Like1 2 Ropporin-1-Like Protein2 AKAP-Associated Sperm Protein2 3
Export aliases for ROPN1L gene to outside databases Previous GC identifers: GC00U917002 GC05P010495
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Summariesfor ROPN1L gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ROPN1L : This gene encodes a member of the ropporin family. The encoded protein is a sperm protein. It interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Type II regulatory subunit of cAMP-dependent protein kinase (PKARII) also binds to this helix domain of AKAP3, which allows PKARII to be targeted to specific subcellular compartments. It is suggested that sperm contains several proteins that bind to AKAPs in a manner similar to PKARII, and this encoded protein may be one of them. Alternatively spliced transcript variants encoding the same protein have been found for this gene.(provided by RefSeq, Jan 2011)
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Genomic Viewsfor ROPN1L gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000005.9 NC_018916.1 NT_006576.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ROPN1L gene promoter: AML1a MEF-2 FOXD3 POU3F2 MEF-2A NRF-2 Msx-1 aMEF-2 Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for ROPN1L Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ROPN1L
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 5p15.2 Ensembl cytogenetic band: 5p15.2 HGNC cytogenetic band: 5p15 ROPN1L Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05P010441: view genomic region
(about GC identifiers )
Start:
10,441,636 bp from pter
End:
10,472,141 bp from pter
Size:
30,506 bases
Orientation:
plus strand
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Proteinsfor ROPN1L gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ROP1L_HUMAN, Q96C74 (See
protein sequence )Recommended Name: Ropporin-1-like protein Size : 230 amino acids; 26107 Da
Subunit : May interact with AKAP3
Secondary accessions : D3DTC9 Q9BZX0Explore the universe of human proteins at neXtProt for ROPN1L: NX_Q96C74 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96C74 ROPN1L Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001188395.1 NP_114122.2 ENSEMBL proteins: ENSP00000421405 ENSP00000274134 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
ROPN1L for ontologies About GeneDecksing ROPN1L Antibody Products: Assay Products for ROPN1L:
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Protein
Domains / Familiesfor ROPN1L gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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ROPN1L for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q96C74 ProtoNet protein and cluster: Q96C74
UniProtKB/Swiss-Prot: ROP1L_HUMAN, Q96C74 Similarity : Belongs to the ropporin familySimilarity : Contains 1 RIIa domain
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Functionfor ROPN1L gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ROPN1L (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ROPN1LOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ROPN1L (NM_031916 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ROPN1L Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ROPN1L
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROPN1L
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
IPI 18421703 GO:0008603 cAMP-dependent protein kinase regulator activity
IEA --
ROPN1L for ontologies About GeneDecksing
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Pathways & Interactionsfor ROPN1L gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ROPN1L STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for ROPN1L (Q96C74 3 ENSP00000274134 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
ROPN1L for ontologies About GeneDecksing
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Drugs & Compoundsfor ROPN1L gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ROPN1L Search CenterWatch for drugs/clinical trials and news about ROPN1L / ROP1L
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Transcriptsfor ROPN1L gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ROPN1L gene (2 alternative transcripts): NM_001201466.1 NM_031916.4 Unigene Cluster for ROPN1L:
Rhophilin associated tail protein 1-like Hs.381089 [show with all ESTs ] Unigene Representative Sequence: BM563234 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000503804 (uc021xwo.1 ) ENST00000274134 (uc003jex.4 ) ENST00000510520 ENST00000515762 ENST00000512022 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ROPN1L (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ROPN1LOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ROPN1L (NM_031916 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ROPN1L Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ROPN1L
Additional cDNA sequence: AF239723.1 AK098642.1 BC014607.2
4 DOTS entries : DT.411819 DT.92417883
DT.100813477 DT.91822001 24/97 AceView cDNA sequences (see all 97 ):
BP370580 AI336237 BM692876 AI671514 AI632455 BM972093 AW593139 BE673052 AI989818 AF239723 AI968785 CR621673 BI826214 BX113042 BM553311 NM_031916 BU680903 BU684136 AL037260 BU679727 BI827363 BI826984 BM975831 AI627427 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for ROPN1L About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b SP1 :                 SP2 :                
ECgene alternative splicing isoforms for ROPN1L
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Expression for ROPN1L gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ROPN1L expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATAGGTCTTT
About this image ROPN1L expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ROPN1L Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ROPN1L SOURCE GeneReport for Unigene cluster: Hs.381089 SABiosciences Custom PCR Arrays for ROPN1L Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ROPN1LBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ROPN1L QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ROPN1L QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ROPN1L In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROPN1L
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Orthologsfor ROPN1L gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for ROPN1L gene from 6/18 species (see all 18 ) About this table
ENSEMBL Gene Tree for ROPN1L (if available)TreeFam Gene Tree for ROPN1L (if available)
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Paralogsfor ROPN1L gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ROPN1L gene ROPN1B 2 ROPN1 2 2 SIMAP similar genes for ROPN1L using alignment to 1 protein entry: ROP1L_HUMAN :ROPN1 ROPN1B
ROPN1L for paralogs About GeneDecksing
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Genomic Variantsfor ROPN1L gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 5 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ROPN1L (10441636 - 10472141 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ROPN1L: -- Human Gene Mutation Database (HGMD) : ROPN1L SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ROPN1L
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Disorders
/ Diseasesfor ROPN1L gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ROPN1L for disorders About GeneDecksing
OMIM gene information: 611756
OMIM disorders : --2 diseases for ROPN1L : About MalaCards breast cancer susceptibility breast cancer Human Genome Epidemiology (HuGE) Navigator: ROPN1L (1 document)Export disorders for ROPN1L gene to outside databases
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Publicationsfor ROPN1L gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ROPN1L gene integrated from 9 sources : (articles sorted by number of sources associating them with ROPN1L) Utopia : connect your pdf to the dynamic world of online information
Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. (PubMed id 11278869) 1 , 2 , 3 Carr D.W....Narumiya S. (2001) Protein kinase A RII-like (R2D2) proteins exhibit differential localization and AKAP interaction. (PubMed id 18421703) 1 , 9 Newell A.E....Carr D.W. (2008) A novel locus for body mass index on 5p15.2: a meta-an alysis of two genome-wide association studies. (PubMed id 22446040) 1 Wang K.S....Callahan K. (2012) Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility. (PubMed id 21424380) 1 Sehrawat B....Damaraju S. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022) 2 Schmutz J.... Rubin E.M. (2004) Human ORFeome version 1.1: a platform for reverse proteomics. (PubMed id 15489335) 1 Rual J.F....Vidal M. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Identification of a murine testis complementary DNA e ncoding a homolog to human A-kinase anchoring protein-associated sperm protein. (PubMed id 12021058) 9 Anway M.D....Griswold M.D. (2002)
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External Searches for ROPN1L gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ROPN1L gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ROPN1L gene
(According to HUGE )
About This Section --
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Specialized Databases showing ROPN1L gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for ROPN1L gene: Search GeneIP for patents involving ROPN1L GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ROPN1L gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ROPN1L OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ROPN1L OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ROPN1L OriGene Protein Over-expression Lysate for ROPN1L Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ROPN1L OriGene 3'-UTR Clone for ROPN1L OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ROPN1L OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ROPN1L Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ROPN1L OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ROPN1L OriGene Custom Protein Services for ROPN1L OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ROPN1L QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ROPN1L QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ROPN1L QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ROPN1L QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ROPN1L QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ROPN1L
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ROPN1L Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROPN1L
ThermoFisher Antibodies for ROPN1L
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ROPN1L
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