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Aliases for ROPN1L Gene

Aliases for ROPN1L Gene

  • Rhophilin Associated Tail Protein 1-Like 2 3
  • ASP 3 4 6
  • AKAP-Associated Sperm Protein 3 4
  • ROPN1-Like Protein 3 4
  • Radial Spoke Head 11 Homolog (Chlamydomonas) 2
  • Radial Spoke Head 11 Homolog 3
  • Ropporin-1-Like Protein 3
  • Ropporin 1-Like 2
  • LINC01513 3
  • RSPH11 3

External Ids for ROPN1L Gene

Previous GeneCards Identifiers for ROPN1L Gene

  • GC00U917002
  • GC05P010495

Summaries for ROPN1L Gene

Entrez Gene Summary for ROPN1L Gene

  • This gene encodes a member of the ropporin family. The encoded protein is present in sperm and interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2014]

GeneCards Summary for ROPN1L Gene

ROPN1L (Rhophilin Associated Tail Protein 1-Like) is a Protein Coding gene. GO annotations related to this gene include cAMP-dependent protein kinase regulator activity. An important paralog of this gene is ROPN1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROPN1L Gene

Genomics for ROPN1L Gene

Regulatory Elements for ROPN1L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ROPN1L Gene

Start:
10,441,524 bp from pter
End:
10,482,319 bp from pter
Size:
40,796 bases
Orientation:
Plus strand

Genomic View for ROPN1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ROPN1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROPN1L Gene

Proteins for ROPN1L Gene

  • Protein details for ROPN1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C74-ROP1L_HUMAN
    Recommended name:
    Ropporin-1-like protein
    Protein Accession:
    Q96C74
    Secondary Accessions:
    • D3DTC9
    • Q9BZX0

    Protein attributes for ROPN1L Gene

    Size:
    230 amino acids
    Molecular mass:
    26107 Da
    Quaternary structure:
    • May interact with AKAP3

neXtProt entry for ROPN1L Gene

Proteomics data for ROPN1L Gene at MOPED

Post-translational modifications for ROPN1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ROPN1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ROPN1L Gene

Domains for ROPN1L Gene

Protein Domains for ROPN1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ROPN1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C74

UniProtKB/Swiss-Prot:

ROP1L_HUMAN :
  • Q96C74
Domain:
  • Contains 1 RIIa domain.
Family:
  • Belongs to the ropporin family.
genes like me logo Genes that share domains with ROPN1L: view

No data available for Gene Families for ROPN1L Gene

Function for ROPN1L Gene

Gene Ontology (GO) - Molecular Function for ROPN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18421703
genes like me logo Genes that share ontologies with ROPN1L: view

Phenotypes for ROPN1L Gene

genes like me logo Genes that share phenotypes with ROPN1L: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ROPN1L

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ROPN1L Gene

Localization for ROPN1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ROPN1L Gene COMPARTMENTS Subcellular localization image for ROPN1L gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ROPN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18421703
GO:0031514 motile cilium IDA 18421703
genes like me logo Genes that share ontologies with ROPN1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ROPN1L Gene

Pathways for ROPN1L Gene

SuperPathways for ROPN1L Gene

No Data Available

Interacting Proteins for ROPN1L Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000274134%0d%0a9606.ENSP00000252655%0d%0a9606.ENSP00000228850%0d%0a
Selected Interacting proteins: ENSP00000274134 Q96C74-ROP1L_HUMAN for ROPN1L Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for ROPN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation IEA --
GO:0003341 cilium movement --
GO:0003351 epithelial cilium movement IC 18421703
GO:0030317 sperm motility IEA --
GO:0048240 sperm capacitation IEA --
genes like me logo Genes that share ontologies with ROPN1L: view

No data available for Pathways by source for ROPN1L Gene

Transcripts for ROPN1L Gene

Unigene Clusters for ROPN1L Gene

Rhophilin associated tail protein 1-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ROPN1L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ROPN1L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ROPN1L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2:

Relevant External Links for ROPN1L Gene

GeneLoc Exon Structure for
ROPN1L
ECgene alternative splicing isoforms for
ROPN1L

Expression for ROPN1L Gene

mRNA expression in normal human tissues for ROPN1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ROPN1L Gene

This gene is overexpressed in Testis (36.7) and Whole Blood (8.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ROPN1L Gene

SOURCE GeneReport for Unigene cluster for ROPN1L Gene Hs.381089

genes like me logo Genes that share expressions with ROPN1L: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ROPN1L Gene

Orthologs for ROPN1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for ROPN1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ROPN1L 35
  • 98.99 (n)
  • 98.26 (a)
ROPN1L 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ROPN1L 35
  • 84.56 (n)
  • 86.24 (a)
ROPN1L 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ROPN1L 35
  • 83.77 (n)
  • 83.48 (a)
ROPN1L 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ropn1l 35
  • 80.25 (n)
  • 79.17 (a)
Ropn1l 16
Ropn1l 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ROPN1L 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ROPN1L 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ropn1l 35
  • 80.09 (n)
  • 78.7 (a)
chicken
(Gallus gallus)
Aves ROPN1L 35
  • 64.44 (n)
  • 60.95 (a)
ROPN1L 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ROPN1L 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16544 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ropn1l 35
  • 58.72 (n)
  • 60.09 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9189 35
zebrafish
(Danio rerio)
Actinopterygii ropn1l 35
  • 58.89 (n)
  • 58.1 (a)
ropn1l 36
  • 56 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4161 36
  • 48 (a)
OneToMany
Species with no ortholog for ROPN1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ROPN1L Gene

ENSEMBL:
Gene Tree for ROPN1L (if available)
TreeFam:
Gene Tree for ROPN1L (if available)

Paralogs for ROPN1L Gene

Paralogs for ROPN1L Gene

Selected SIMAP similar genes for ROPN1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ROPN1L: view

Variants for ROPN1L Gene

Sequence variations from dbSNP and Humsavar for ROPN1L Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs814597 -- 10,468,817(+) TTTAG(C/T)ACCTC intron-variant
rs861502 -- 10,468,580(+) TATTT(A/G)ATAAC intron-variant
rs904512 -- 10,445,844(+) CTTGA(A/G)CCCAG intron-variant
rs904513 -- 10,446,002(+) AAAGG(A/T)GCTTT intron-variant
rs904515 -- 10,446,073(+) AGGGG(A/G)GTCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ROPN1L Gene

Variant ID Type Subtype PubMed ID
nsv880520 CNV Gain 21882294
nsv880973 CNV Gain 21882294
esv990013 CNV Insertion 20482838
esv1398505 CNV Insertion 17803354
nsv329900 CNV Insertion 16902084

Relevant External Links for ROPN1L Gene

HapMap Linkage Disequilibrium report
ROPN1L
Human Gene Mutation Database (HGMD)
ROPN1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROPN1L Gene

Disorders for ROPN1L Gene

Relevant External Links for ROPN1L

Genetic Association Database (GAD)
ROPN1L
Human Genome Epidemiology (HuGE) Navigator
ROPN1L
genes like me logo Genes that share disorders with ROPN1L: view

No data available for UniProtKB/Swiss-Prot for ROPN1L Gene

Publications for ROPN1L Gene

  1. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. (PMID: 11278869) Carr D.W. … Narumiya S. (J. Biol. Chem. 2001) 2 3 4
  2. A novel locus for body mass index on 5p15.2: a meta-analysis of two genome-wide association studies. (PMID: 22446040) Wang K.S. … Callahan K. (Gene 2012) 3 48
  3. Protein kinase A RII-like (R2D2) proteins exhibit differential localization and AKAP interaction. (PMID: 18421703) Newell A.E. … Carr D.W. (Cell Motil. Cytoskeleton 2008) 3 23
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. Identification of a murine testis complementary DNA encoding a homolog to human A-kinase anchoring protein-associated sperm protein. (PMID: 12021058) Anway M.D. … Griswold M.D. (Biol. Reprod. 2002) 23

Products for ROPN1L Gene

Sources for ROPN1L Gene

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