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Aliases for ROPN1L Gene

Aliases for ROPN1L Gene

  • Rhophilin Associated Tail Protein 1 Like 2
  • Rhophilin Associated Tail Protein 1-Like 2 3 5
  • AKAP-Associated Sperm Protein 3 4
  • ROPN1-Like Protein 3 4
  • ASP 3 4
  • Radial Spoke Head 11 Homolog (Chlamydomonas) 2
  • Radial Spoke Head 11 Homolog 3
  • Ropporin 1-Like 2
  • RSPH11 3

External Ids for ROPN1L Gene

Previous GeneCards Identifiers for ROPN1L Gene

  • GC00U917002
  • GC05P010495

Summaries for ROPN1L Gene

Entrez Gene Summary for ROPN1L Gene

  • This gene encodes a member of the ropporin family. The encoded protein is present in sperm and interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2014]

GeneCards Summary for ROPN1L Gene

ROPN1L (Rhophilin Associated Tail Protein 1 Like) is a Protein Coding gene. Diseases associated with ROPN1L include opisthorchiasis. An important paralog of this gene is ROPN1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROPN1L Gene

Genomics for ROPN1L Gene

Regulatory Elements for ROPN1L Gene

Promoters for ROPN1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ROPN1L on UCSC Golden Path with GeneCards custom track

Genomic Location for ROPN1L Gene

Chromosome:
5
Start:
10,441,524 bp from pter
End:
10,482,298 bp from pter
Size:
40,775 bases
Orientation:
Plus strand

Genomic View for ROPN1L Gene

Genes around ROPN1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ROPN1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ROPN1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROPN1L Gene

Proteins for ROPN1L Gene

  • Protein details for ROPN1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C74-ROP1L_HUMAN
    Recommended name:
    Ropporin-1-like protein
    Protein Accession:
    Q96C74
    Secondary Accessions:
    • D3DTC9
    • Q9BZX0

    Protein attributes for ROPN1L Gene

    Size:
    230 amino acids
    Molecular mass:
    26107 Da
    Quaternary structure:
    • May interact with AKAP3.

neXtProt entry for ROPN1L Gene

Proteomics data for ROPN1L Gene at MOPED

Post-translational modifications for ROPN1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ROPN1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ROPN1L Gene

Domains & Families for ROPN1L Gene

Protein Domains for ROPN1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ROPN1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C74

UniProtKB/Swiss-Prot:

ROP1L_HUMAN :
  • Contains 1 RIIa domain.
  • Belongs to the ropporin family.
Domain:
  • Contains 1 RIIa domain.
Family:
  • Belongs to the ropporin family.
genes like me logo Genes that share domains with ROPN1L: view

No data available for Gene Families for ROPN1L Gene

Function for ROPN1L Gene

Phenotypes for ROPN1L Gene

genes like me logo Genes that share phenotypes with ROPN1L: view

Animal Models for ROPN1L Gene

MGI Knock Outs for ROPN1L:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ROPN1L Gene

Localization for ROPN1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ROPN1L Gene COMPARTMENTS Subcellular localization image for ROPN1L gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ROPN1L Gene

Pathways & Interactions for ROPN1L Gene

SuperPathways for ROPN1L Gene

No Data Available

Interacting Proteins for ROPN1L Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000274134%0d%0a9606.ENSP00000252655%0d%0a9606.ENSP00000228850%0d%0a
Selected Interacting proteins: Q96C74-ROP1L_HUMAN ENSP00000274134 for ROPN1L Gene via I2D UniProtKB STRING

Gene Ontology (GO) - Biological Process for ROPN1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ROPN1L Gene

Drugs & Compounds for ROPN1L Gene

No Compound Related Data Available

Transcripts for ROPN1L Gene

Unigene Clusters for ROPN1L Gene

Rhophilin associated tail protein 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ROPN1L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2:

Relevant External Links for ROPN1L Gene

GeneLoc Exon Structure for
ROPN1L
ECgene alternative splicing isoforms for
ROPN1L

Expression for ROPN1L Gene

mRNA expression in normal human tissues for ROPN1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ROPN1L Gene

This gene is overexpressed in Testis (x36.7) and Whole Blood (x8.3).

Protein differential expression in normal tissues from HIPED for ROPN1L Gene

This gene is overexpressed in Testis (40.7) and Ovary (28.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ROPN1L Gene



SOURCE GeneReport for Unigene cluster for ROPN1L Gene Hs.381089

genes like me logo Genes that share expression patterns with ROPN1L: view

Protein tissue co-expression partners for ROPN1L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ROPN1L Gene

Orthologs for ROPN1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for ROPN1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ROPN1L 35
  • 84.56 (n)
  • 86.24 (a)
ROPN1L 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ROPN1L 35
  • 83.77 (n)
  • 83.48 (a)
ROPN1L 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ropn1l 35
  • 80.25 (n)
  • 79.17 (a)
Ropn1l 16
Ropn1l 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ROPN1L 35
  • 98.99 (n)
  • 98.26 (a)
ROPN1L 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ropn1l 35
  • 80.09 (n)
  • 78.7 (a)
oppossum
(Monodelphis domestica)
Mammalia ROPN1L 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ROPN1L 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ROPN1L 35
  • 64.44 (n)
  • 60.95 (a)
ROPN1L 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ROPN1L 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ropn1l 35
  • 58.72 (n)
  • 60.09 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16544 35
zebrafish
(Danio rerio)
Actinopterygii ropn1l 35
  • 58.89 (n)
  • 58.1 (a)
ropn1l 36
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9189 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4161 36
  • 48 (a)
OneToMany
Species with no ortholog for ROPN1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ROPN1L Gene

ENSEMBL:
Gene Tree for ROPN1L (if available)
TreeFam:
Gene Tree for ROPN1L (if available)

Paralogs for ROPN1L Gene

Paralogs for ROPN1L Gene

(2) SIMAP similar genes for ROPN1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ROPN1L: view

Variants for ROPN1L Gene

Sequence variations from dbSNP and Humsavar for ROPN1L Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs35573613 - 10,450,005(-) CACAA(G/T)TTCTT reference, missense
VAR_035443 -
rs2303986 - 10,450,034(-) AGAGC(A/G)CTTTG reference, missense
rs861502 -- 10,468,580(+) TATTT(A/G)ATAAC intron-variant
rs938453 -- 10,460,344(+) CCCTG(C/G)GGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ROPN1L Gene

Variant ID Type Subtype PubMed ID
nsv880520 CNV Gain 21882294
nsv880973 CNV Gain 21882294
esv990013 CNV Insertion 20482838
esv1398505 CNV Insertion 17803354
nsv329900 CNV Insertion 16902084

Variation tolerance for ROPN1L Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ROPN1L Gene

HapMap Linkage Disequilibrium report
ROPN1L
Human Gene Mutation Database (HGMD)
ROPN1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROPN1L Gene

Disorders for ROPN1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for ROPN1L Gene - From: DISEASES

Disorder Aliases PubMed IDs
opisthorchiasis
  • infection by opisthorchis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ROPN1L

Genetic Association Database (GAD)
ROPN1L
Human Genome Epidemiology (HuGE) Navigator
ROPN1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ROPN1L
genes like me logo Genes that share disorders with ROPN1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ROPN1L Gene

Publications for ROPN1L Gene

  1. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. (PMID: 11278869) Carr D.W. … Narumiya S. (J. Biol. Chem. 2001) 2 3 4 67
  2. Protein kinase A RII-like (R2D2) proteins exhibit differential localization and AKAP interaction. (PMID: 18421703) Newell A.E. … Carr D.W. (Cell Motil. Cytoskeleton 2008) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Long noncoding RNA expression profiles of lung adenocarcinoma ascertained by microarray analysis. (PMID: 25089627) Xu G. … Wang Y. (PLoS ONE 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ROPN1L Gene

Sources for ROPN1L Gene

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