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Aliases for ROPN1L Gene

Aliases for ROPN1L Gene

  • Rhophilin Associated Tail Protein 1 Like 2 3 5
  • AKAP-Associated Sperm Protein 3 4
  • ROPN1-Like Protein 3 4
  • ASP 3 4
  • Radial Spoke Head 11 Homolog (Chlamydomonas) 2
  • Rhophilin Associated Tail Protein 1-Like 2
  • Radial Spoke Head 11 Homolog 3
  • Ropporin-1-Like Protein 3
  • Ropporin 1-Like 2
  • RSPH11 3

External Ids for ROPN1L Gene

Previous GeneCards Identifiers for ROPN1L Gene

  • GC00U917002
  • GC05P010495

Summaries for ROPN1L Gene

Entrez Gene Summary for ROPN1L Gene

  • This gene encodes a member of the ropporin family. The encoded protein is present in sperm and interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2014]

GeneCards Summary for ROPN1L Gene

ROPN1L (Rhophilin Associated Tail Protein 1 Like) is a Protein Coding gene. Diseases associated with ROPN1L include Opisthorchiasis. An important paralog of this gene is ROPN1.

Additional gene information for ROPN1L Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROPN1L Gene

Genomics for ROPN1L Gene

Regulatory Elements for ROPN1L Gene

Enhancers for ROPN1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H010606 1.6 FANTOM5 Ensembl ENCODE 11 +166.2 166241 2.5 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF766 JUNB REST ZNF592 ROPN1L-AS1 ANKRD33B CTD-2154B17.1 LINC02221 ENSG00000248525 ANKRD33B-AS1 LINC02213 ROPN1L FAM173B LINC01513
GH05H010550 1.5 FANTOM5 Ensembl ENCODE 10 +110.1 110109 3.1 PKNOX1 BRCA1 GLIS2 KLF7 FOS RUNX3 DEK SP3 REST SMARCB1 LINC02213 ANKRD33B-AS1 ROPN1L-AS1 ROPN1L ENSG00000279450 ENSG00000280017
GH05H010304 1.6 Ensembl ENCODE dbSUPER 9.2 -133.3 -133324 6.6 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 MARCH6 CMBL ROPN1L ROPN1L-AS1 FAM173B CCT5 ENSG00000271980 LOC105374651
GH05H010588 1.3 Ensembl ENCODE 11 +148.4 148421 3.5 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 ELK1 ATF7 ANKRD33B ANKRD33B-AS1 ROPN1L ROPN1L-AS1 ENSG00000251196 GC05P010586 GC05P010606
GH05H010248 1.4 ENCODE dbSUPER 10.2 -191.2 -191164 4.1 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ROPN1L-AS1 CCT5 LINC02221 CTD-2154B17.1 ENSG00000248525 ENSG00000250001 MARCH6 CMBL ENSG00000271980 ROPN1L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ROPN1L on UCSC Golden Path with GeneCards custom track

Promoters for ROPN1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000178068 376 1001 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF121 ZNF766

Genomic Locations for ROPN1L Gene

Genomic Locations for ROPN1L Gene
40,775 bases
Plus strand

Genomic View for ROPN1L Gene

Genes around ROPN1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ROPN1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ROPN1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROPN1L Gene

Proteins for ROPN1L Gene

  • Protein details for ROPN1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ropporin-1-like protein
    Protein Accession:
    Secondary Accessions:
    • D3DTC9
    • Q9BZX0

    Protein attributes for ROPN1L Gene

    230 amino acids
    Molecular mass:
    26107 Da
    Quaternary structure:
    • May interact with AKAP3.

neXtProt entry for ROPN1L Gene

Post-translational modifications for ROPN1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ROPN1L Gene

No data available for DME Specific Peptides for ROPN1L Gene

Domains & Families for ROPN1L Gene

Gene Families for ROPN1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ROPN1L Gene

Suggested Antigen Peptide Sequences for ROPN1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ropporin family.
  • Belongs to the ropporin family.
genes like me logo Genes that share domains with ROPN1L: view

Function for ROPN1L Gene

Phenotypes From GWAS Catalog for ROPN1L Gene

Gene Ontology (GO) - Molecular Function for ROPN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18421703
genes like me logo Genes that share ontologies with ROPN1L: view

Phenotypes for ROPN1L Gene

genes like me logo Genes that share phenotypes with ROPN1L: view

Animal Models for ROPN1L Gene

MGI Knock Outs for ROPN1L:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ROPN1L Gene

Localization for ROPN1L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ROPN1L gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ROPN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18421703
GO:0031514 motile cilium IDA 18421703
genes like me logo Genes that share ontologies with ROPN1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ROPN1L Gene

Pathways & Interactions for ROPN1L Gene

SuperPathways for ROPN1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for ROPN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation ISS --
GO:0003351 epithelial cilium movement IC 18421703
GO:0030317 flagellated sperm motility ISS --
GO:0048240 sperm capacitation ISS --
genes like me logo Genes that share ontologies with ROPN1L: view

No data available for Pathways by source and SIGNOR curated interactions for ROPN1L Gene

Drugs & Compounds for ROPN1L Gene

No Compound Related Data Available

Transcripts for ROPN1L Gene

Unigene Clusters for ROPN1L Gene

Rhophilin associated tail protein 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ROPN1L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b

Relevant External Links for ROPN1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ROPN1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ROPN1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ROPN1L Gene

This gene is overexpressed in Testis (x36.7) and Whole Blood (x8.3).

Protein differential expression in normal tissues from HIPED for ROPN1L Gene

This gene is overexpressed in Testis (40.7) and Ovary (28.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ROPN1L Gene

Protein tissue co-expression partners for ROPN1L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ROPN1L Gene:


SOURCE GeneReport for Unigene cluster for ROPN1L Gene:


Evidence on tissue expression from TISSUES for ROPN1L Gene

  • Nervous system(4.5)
  • Lung(2.6)
genes like me logo Genes that share expression patterns with ROPN1L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ROPN1L Gene

Orthologs for ROPN1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for ROPN1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ROPN1L 33 34
  • 98.99 (n)
(Bos Taurus)
Mammalia ROPN1L 33 34
  • 84.56 (n)
(Canis familiaris)
Mammalia ROPN1L 33 34
  • 83.77 (n)
(Mus musculus)
Mammalia Ropn1l 33 16 34
  • 80.25 (n)
(Rattus norvegicus)
Mammalia Ropn1l 33
  • 80.09 (n)
(Ornithorhynchus anatinus)
Mammalia ROPN1L 34
  • 71 (a)
(Monodelphis domestica)
Mammalia ROPN1L 34
  • 67 (a)
(Gallus gallus)
Aves ROPN1L 33 34
  • 64.44 (n)
(Anolis carolinensis)
Reptilia ROPN1L 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ropn1l 33
  • 58.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16544 33
(Danio rerio)
Actinopterygii ropn1l 33 34
  • 58.89 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9189 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4161 34
  • 48 (a)
Species where no ortholog for ROPN1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ROPN1L Gene

Gene Tree for ROPN1L (if available)
Gene Tree for ROPN1L (if available)

Paralogs for ROPN1L Gene

Paralogs for ROPN1L Gene

(2) SIMAP similar genes for ROPN1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ROPN1L: view

Variants for ROPN1L Gene

Sequence variations from dbSNP and Humsavar for ROPN1L Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000179500 -- 10,443,393(+) CGAGG(C/T)GGGTG intron-variant, upstream-variant-2KB
rs1000301540 -- 10,466,655(+) AGGCC(C/T)GTCCC intron-variant
rs1000330300 -- 10,461,853(+) GAAGA(C/T)AGACA intron-variant, upstream-variant-2KB
rs1000346262 -- 10,453,344(+) GACAG(A/G)AGGTG intron-variant
rs1000374615 -- 10,466,432(+) CTCAG(C/T)GTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ROPN1L Gene

Variant ID Type Subtype PubMed ID
esv1398505 CNV insertion 17803354
esv990013 CNV insertion 20482838
nsv329900 CNV insertion 16902084
nsv950647 CNV deletion 24416366

Variation tolerance for ROPN1L Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ROPN1L Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROPN1L Gene

Disorders for ROPN1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for ROPN1L Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
  • infection by opisthorchis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ROPN1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ROPN1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ROPN1L Gene

Publications for ROPN1L Gene

  1. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. (PMID: 11278869) Carr DW … Narumiya S (The Journal of biological chemistry 2001) 2 3 4 60
  2. A novel locus for body mass index on 5p15.2: a meta-analysis of two genome-wide association studies. (PMID: 22446040) Wang KS … Callahan K (Gene 2012) 3 45 60
  3. Protein kinase A RII-like (R2D2) proteins exhibit differential localization and AKAP interaction. (PMID: 18421703) Newell AE … Carr DW (Cell motility and the cytoskeleton 2008) 3 22 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Sperm protein 17 and AKAP-associated sperm protein cancer/testis antigens are expressed in ciliated hepatic foregut cysts. (PMID: 25600306) Grizzi F … Fernández-Aceñero MJ (Histopathology 2015) 3 60

Products for ROPN1L Gene

Sources for ROPN1L Gene

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