ROPN1B Gene
protein-coding GIFtS: 41
GCID: GC03P125688
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rhophilin associated tail protein 1B(Previous names: ropporin, rhophilin associated protein 1B )
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Aliases
for ROPN1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rhophilin Associated Tail Protein 1B1 2 | | Ropporin, Rhophilin Associated Protein 1B1 2 | | Rhophilin-Associated Protein 1B2 3 | | AKAP-Binding Sperm Protein Ropporin2 | | Ropporin-1B1 |
Export aliases for ROPN1B gene to outside databasesPrevious GC identifers: GC03P127171 GC03P123068 |
Summaries
for ROPN1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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-- |
Genomic Views
for ROPN1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ROPN1B gene promoter:
RFX1 NF-1 NF-1/L Pax-5 GATA-2 CREB c-Myb Cart-1 RSRFC4 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for ROPN1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ROPN1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21.2 Ensembl cytogenetic band: 3q21.2 HGNC cytogenetic band: 3q21.2ROPN1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P125688: view genomic region
(about GC identifiers)
Start:
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125,687,987 bp from pter |
End:
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125,702,297 bp from pter |
Size:
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14,311 bases |
Orientation:
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plus strand |
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Proteins
for ROPN1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ROP1B_HUMAN, Q9BZX4 (See
protein sequence)Recommended Name: Ropporin-1B Size: 212 amino acids; 23964 Da
Subunit: Homodimer. Interacts with RHPN1. May interact with SPA17 (By similarity). Interacts with AKAP3
Subcellular location: Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located atthe distal end of the midpiece. Inner surface of the fibrous sheath (By similarity)
Miscellaneous: 'Ropporin' comes from the Japanese word 'oppo' which means 'tail'
Secondary accessions: D3DNA6 Q96BM7Alternative splicing: 2 isoforms: Q9BZX4-1 Q9BZX4-2 Explore the universe of human proteins at neXtProt for ROPN1B: NX_Q9BZX4
ROPN1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001012337.1
ENSEMBL proteins: ENSP00000426271 ENSP00000251776 ENSP00000424457 ENSP00000425548 ENSP00000423058 ENSP00000422819 ENSP00000421662 ENSP00000424447
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ROPN1B for ontologies About GeneDecksing
ROPN1B Antibody Products:
Assay Products for ROPN1B: |
Protein
Domains /
Families
for ROPN1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ROPN1B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BZX4ProtoNet protein and cluster: Q9BZX4 UniProtKB/Swiss-Prot: ROP1B_HUMAN, Q9BZX4Domain: The RIIa domain mediates interaction with AKAP3Similarity: Belongs to the ropporin familySimilarity: Contains 1 RIIa domain |
Function
for ROPN1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ROPN1B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ROPN1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ROPN1B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROPN1B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROPN1B |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ROPN1B for ontologies About GeneDecksing
|
Pathways & Interactions
for ROPN1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ROPN1B
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for ROPN1B (Q9BZX43 ENSP000002517764) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
ROPN1B for ontologies About GeneDecksing
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Drugs & Compounds
for ROPN1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ROPN1B
Search CenterWatch for drugs/clinical trials and news about ROPN1B / ROP1B
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Transcripts
for ROPN1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ROPN1B gene: NM_001012337.1 Unigene Cluster for ROPN1B: Rhophilin associated tail protein 1B Hs.663128 [show with all ESTs]Unigene Representative Sequence: AK30201411 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000514116(uc010hsb.3) ENST00000251776(uc003eih.3) ENST00000504401
ENST00000513830 ENST00000511862 ENST00000511035 ENST00000508088 ENST00000509879
ENST00000510450(uc011bkg.2) ENST00000505382 ENST00000511082(uc010hsc.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ROPN1B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ROPN1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ROPN1B (NM_001012337) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ROPN1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROPN1B |
Additional cDNA sequence: AF231410.1 AK302014.1 BC015413.1 BC141849.1 7 DOTS entries: DT.95169569 DT.92422267 DT.92422269 DT.92422268 DT.441723 DT.95186292 DT.120892359 23 AceView cDNA sequences: BI828359 BM554135 BI831090 BC015413 AF231410 AL037365 BM559594 CB989847 BG771571 BG704322 BG719581 BM552738 BI826006 BG719580 BG034740 BI830464 BG719672 AA506126 AI016755 BE894254 BI828708 BI560054 CD708847
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ROPN1B About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 |
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| SP1: | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ROPN1B
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Expression
for ROPN1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ROPN1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAGATCAGA
About this image
See ROPN1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ROPN1B
SOURCE GeneReport for Unigene cluster: Hs.663128
SABiosciences Custom PCR Arrays for ROPN1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ROPN1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ROPN1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ROPN1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ROPN1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROPN1B |
Orthologs
for ROPN1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ROPN1B gene from 1/10 species (see all 10) About this table
ENSEMBL Gene Tree for ROPN1B (if available)
TreeFam Gene Tree for ROPN1B (if available) |
Paralogs
for ROPN1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ROPN1B gene
- ROPN1L2 ROPN12
5 SIMAP similar genes for ROPN1B using alignment to 5 protein entries: ROP1B_HUMAN (see all proteins):MT-ND1 NADH1 ND1 ROPN1 ROPN1L
ROPN1B for paralogs About GeneDecksing
|
Genomic Variants
for ROPN1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for ROPN1B (125687987 - 125702297 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ROPN1B
3 CNVs: 4352 36050 3446 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ROPN1B |
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Disorders
/ Diseases
for ROPN1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ROPN1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ROPN1B gene integrated from 9 sources:
(articles sorted by number of sources associating them with ROPN1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. (PubMed id 11278869)1, 2 Carr D.W....Narumiya S. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. (PubMed id 10591629)1 Fujita A....Narumiya S. (2000)
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External Searches for ROPN1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ROPN1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing ROPN1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ROPN1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ROPN1B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ROPN1B gene:
Search GeneIP for patents involving ROPN1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ROPN1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 |  |  |  | |
| | | | Search Tocris compounds for ROPN1B |
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 | | | ROPN1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROPN1B |
|  |  |  | | | | Search ThermoFisher Antibodies for ROPN1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROPN1B |
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