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Aliases for ROPN1B Gene

Aliases for ROPN1B Gene

  • Rhophilin Associated Tail Protein 1B 2 3
  • Ropporin, Rhophilin Associated Protein 1B 2 3
  • Rhophilin-Associated Protein 1B 3 4
  • AKAP-Binding Sperm Protein Ropporin 3
  • Ropporin-1B 3

External Ids for ROPN1B Gene

Previous GeneCards Identifiers for ROPN1B Gene

  • GC03P127171
  • GC03P125688
  • GC03P123068

Summaries for ROPN1B Gene

GeneCards Summary for ROPN1B Gene

ROPN1B (Rhophilin Associated Tail Protein 1B) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and cAMP-dependent protein kinase regulator activity. An important paralog of this gene is ROPN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROPN1B Gene

Genomics for ROPN1B Gene

Regulatory Elements for ROPN1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ROPN1B Gene

125,969,144 bp from pter
125,983,455 bp from pter
14,312 bases
Plus strand

Genomic View for ROPN1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ROPN1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROPN1B Gene

Proteins for ROPN1B Gene

  • Protein details for ROPN1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DNA6
    • Q96BM7

    Protein attributes for ROPN1B Gene

    212 amino acids
    Molecular mass:
    23964 Da
    Quaternary structure:
    • Homodimer. Interacts with RHPN1. May interact with SPA17 (By similarity). Interacts with AKAP3.
    • Ropporin comes from the Japanese word oppo which means tail

    Alternative splice isoforms for ROPN1B Gene


neXtProt entry for ROPN1B Gene

Proteomics data for ROPN1B Gene at MOPED

Post-translational modifications for ROPN1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ROPN1B Gene

No data available for DME Specific Peptides for ROPN1B Gene

Domains for ROPN1B Gene

Protein Domains for ROPN1B Gene


Suggested Antigen Peptide Sequences for ROPN1B Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9BZX4
  • The RIIa domain mediates interaction with AKAP3
  • Contains 1 RIIa domain.
  • Belongs to the ropporin family.
genes like me logo Genes that share domains with ROPN1B: view

No data available for Gene Families for ROPN1B Gene

Function for ROPN1B Gene

Gene Ontology (GO) - Molecular Function for ROPN1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11278869
GO:0030159 receptor signaling complex scaffold activity NAS 11278869
GO:0042803 protein homodimerization activity NAS 11278869
GO:0046982 protein heterodimerization activity IPI 11278869
genes like me logo Genes that share ontologies with ROPN1B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ROPN1B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ROPN1B Gene

Localization for ROPN1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ROPN1B Gene

Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath (By similarity). .

Subcellular locations from

Jensen Localization Image for ROPN1B Gene COMPARTMENTS Subcellular localization image for ROPN1B gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ROPN1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11278869
GO:0031514 motile cilium IDA 11278869
genes like me logo Genes that share ontologies with ROPN1B: view

Pathways for ROPN1B Gene

SuperPathways for ROPN1B Gene

No Data Available

Interacting Proteins for ROPN1B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000251776 Q9BZX4-ROP1B_HUMAN for ROPN1B Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for ROPN1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis NAS 11278869
GO:0007266 Rho protein signal transduction TAS 11278869
GO:0007283 spermatogenesis NAS 11278869
GO:0007340 acrosome reaction NAS 11278869
GO:0007342 fusion of sperm to egg plasma membrane NAS 11278869
genes like me logo Genes that share ontologies with ROPN1B: view

No data available for Pathways by source for ROPN1B Gene

Transcripts for ROPN1B Gene

Unigene Clusters for ROPN1B Gene

Rhophilin associated tail protein 1B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ROPN1B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ROPN1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1: - -
SP4: - - -

Relevant External Links for ROPN1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ROPN1B Gene

mRNA expression in normal human tissues for ROPN1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ROPN1B Gene

This gene is overexpressed in Testis (39.0).

Protein differential expression in normal tissues for ROPN1B Gene

This gene is overexpressed in Ovary (57.2) and Testis (11.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ROPN1B Gene

SOURCE GeneReport for Unigene cluster for ROPN1B Gene Hs.663128

genes like me logo Genes that share expressions with ROPN1B: view

Expression partners for ROPN1B Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ROPN1B Gene

Orthologs for ROPN1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ROPN1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ROPN1B 35
  • 98.27 (n)
  • 98.11 (a)
  • 98 (a)
(Bos Taurus)
Mammalia ROPN1 36
  • 86 (a)
(Canis familiaris)
Mammalia -- 36
  • 87 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
(Mus musculus)
Mammalia Ropn1 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4161 36
  • 37 (a)
Species with no ortholog for ROPN1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ROPN1B Gene

Gene Tree for ROPN1B (if available)
Gene Tree for ROPN1B (if available)

Paralogs for ROPN1B Gene

Paralogs for ROPN1B Gene

Selected SIMAP similar genes for ROPN1B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ROPN1B: view

Variants for ROPN1B Gene

Sequence variations from dbSNP and Humsavar for ROPN1B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1503070 -- 125,974,296(-) GAAAT(A/C)TCTGC intron-variant
rs2270986 -- 125,982,256(-) GTTAC(A/G)TAAAA intron-variant
rs3811676 -- 125,973,907(+) GTCAA(C/T)GAAGA intron-variant
rs3863982 -- 125,977,453(-) GGAGC(A/G)GAGTG intron-variant
rs3902540 -- 125,969,341(-) CCTCA(A/G)GCGAG utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ROPN1B Gene

Variant ID Type Subtype PubMed ID
dgv1491e1 CNV Complex 17122850
nsv877410 CNV Loss 21882294
nsv829716 CNV Gain+Loss 17160897
nsv3984 CNV Loss 18451855

Relevant External Links for ROPN1B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROPN1B Gene

Disorders for ROPN1B Gene

No disorders were found for ROPN1B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ROPN1B Gene

Publications for ROPN1B Gene

  1. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. (PMID: 11278869) Carr D.W. … Narumiya S. (J. Biol. Chem. 2001) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. (PMID: 10591629) Fujita A. … Narumiya S. (J. Cell. Sci. 2000) 3

Products for ROPN1B Gene

Sources for ROPN1B Gene

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