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Aliases for ROPN1B Gene

Aliases for ROPN1B Gene

  • Rhophilin Associated Tail Protein 1B 2 3 5
  • Ropporin, Rhophilin Associated Protein 1B 2
  • Rhophilin-Associated Protein 1B 4

External Ids for ROPN1B Gene

Previous GeneCards Identifiers for ROPN1B Gene

  • GC03P127171
  • GC03P125688
  • GC03P123068

Summaries for ROPN1B Gene

GeneCards Summary for ROPN1B Gene

ROPN1B (Rhophilin Associated Tail Protein 1B) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and receptor signaling complex scaffold activity. An important paralog of this gene is ROPN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROPN1B Gene

Genomics for ROPN1B Gene

Regulatory Elements for ROPN1B Gene

Enhancers for ROPN1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ROPN1B on UCSC Golden Path with GeneCards custom track

Genomic Location for ROPN1B Gene

125,969,144 bp from pter
125,983,454 bp from pter
14,311 bases
Plus strand

Genomic View for ROPN1B Gene

Genes around ROPN1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ROPN1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ROPN1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROPN1B Gene

Proteins for ROPN1B Gene

  • Protein details for ROPN1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DNA6
    • Q96BM7

    Protein attributes for ROPN1B Gene

    212 amino acids
    Molecular mass:
    23964 Da
    Quaternary structure:
    • Homodimer. Interacts with RHPN1. May interact with SPA17 (By similarity). Interacts with AKAP3.
    • Ropporin comes from the Japanese word oppo which means tail.

    Alternative splice isoforms for ROPN1B Gene


neXtProt entry for ROPN1B Gene

Proteomics data for ROPN1B Gene at MOPED

Post-translational modifications for ROPN1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ROPN1B Gene

Domains & Families for ROPN1B Gene

Protein Domains for ROPN1B Gene


Suggested Antigen Peptide Sequences for ROPN1B Gene

Graphical View of Domain Structure for InterPro Entry



  • The RIIa domain mediates interaction with AKAP3.
  • Belongs to the ropporin family.
  • The RIIa domain mediates interaction with AKAP3.
  • Contains 1 RIIa domain.
  • Belongs to the ropporin family.
genes like me logo Genes that share domains with ROPN1B: view

No data available for Gene Families for ROPN1B Gene

Function for ROPN1B Gene

Gene Ontology (GO) - Molecular Function for ROPN1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity NAS 11278869
genes like me logo Genes that share ontologies with ROPN1B: view
genes like me logo Genes that share phenotypes with ROPN1B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ROPN1B Gene

Localization for ROPN1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ROPN1B Gene

Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath (By similarity). .

Subcellular locations from

Jensen Localization Image for ROPN1B Gene COMPARTMENTS Subcellular localization image for ROPN1B gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for ROPN1B Gene

Pathways & Interactions for ROPN1B Gene

SuperPathways for ROPN1B Gene

No Data Available

Interacting Proteins for ROPN1B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000251776 Q9BZX4-ROP1B_HUMAN for ROPN1B Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for ROPN1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis NAS 11278869
GO:0007283 spermatogenesis NAS 11278869
GO:0007342 fusion of sperm to egg plasma membrane NAS 11278869
GO:0016337 single organismal cell-cell adhesion NAS 11278869
GO:0030317 sperm motility TAS 11278869
genes like me logo Genes that share ontologies with ROPN1B: view

No data available for Pathways by source and SIGNOR curated interactions for ROPN1B Gene

Drugs & Compounds for ROPN1B Gene

No Compound Related Data Available

Transcripts for ROPN1B Gene

Unigene Clusters for ROPN1B Gene

Rhophilin associated tail protein 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ROPN1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1: - -
SP4: - - -

Relevant External Links for ROPN1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ROPN1B Gene

mRNA expression in normal human tissues for ROPN1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ROPN1B Gene

This gene is overexpressed in Testis (x39.0).

Protein differential expression in normal tissues from HIPED for ROPN1B Gene

This gene is overexpressed in Ovary (57.2) and Testis (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ROPN1B Gene

SOURCE GeneReport for Unigene cluster for ROPN1B Gene Hs.663128

genes like me logo Genes that share expression patterns with ROPN1B: view

Protein tissue co-expression partners for ROPN1B Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ROPN1B Gene

Orthologs for ROPN1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ROPN1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ROPN1B 35
  • 98.27 (n)
  • 98.11 (a)
  • 98 (a)
(Bos Taurus)
Mammalia ROPN1 36
  • 86 (a)
(Canis familiaris)
Mammalia -- 36
  • 87 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
(Mus musculus)
Mammalia Ropn1 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4161 36
  • 37 (a)
Species with no ortholog for ROPN1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ROPN1B Gene

Gene Tree for ROPN1B (if available)
Gene Tree for ROPN1B (if available)

Paralogs for ROPN1B Gene

Paralogs for ROPN1B Gene

(6) SIMAP similar genes for ROPN1B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ROPN1B: view

Variants for ROPN1B Gene

Sequence variations from dbSNP and Humsavar for ROPN1B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs4300968 -- 125,976,191(+) GTTTG(A/G)CCAAT intron-variant
rs4384909 -- 125,971,665(+) CATGA(C/T)ATACT intron-variant
rs4450757 -- 125,967,613(+) TGGCC(A/G)TCCCC upstream-variant-2KB
rs4450758 -- 125,967,918(+) TTTCA(A/T)ATGGG upstream-variant-2KB
rs4456817 -- 125,970,306(+) ATTCC(A/G)AACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ROPN1B Gene

Variant ID Type Subtype PubMed ID
dgv1491e1 CNV Complex 17122850
nsv877410 CNV Loss 21882294
nsv829716 CNV Gain+Loss 17160897
nsv3984 CNV Loss 18451855

Variation tolerance for ROPN1B Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ROPN1B Gene

Disorders for ROPN1B Gene

Relevant External Links for ROPN1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ROPN1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ROPN1B Gene

Publications for ROPN1B Gene

  1. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. (PMID: 11278869) Carr D.W. … Narumiya S. (J. Biol. Chem. 2001) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. (PMID: 10591629) Fujita A. … Narumiya S. (J. Cell. Sci. 2000) 3

Products for ROPN1B Gene

Sources for ROPN1B Gene