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Aliases for ROPN1 Gene

Aliases for ROPN1 Gene

  • Rhophilin Associated Tail Protein 1 2 3 5
  • Cancer/Testis Antigen 91 2 3 4
  • Ropporin, Rhophilin Associated Protein 1 2 3
  • Rhophilin-Associated Protein 1A 3 4
  • ROPN1A 3 4
  • CT91 3 4
  • Testis Secretory Sperm-Binding Protein Li 239w 3
  • Outer Dense Fiber Of Sperm Tails 6 3
  • Ropporin 3
  • RHPNAP1 3
  • ODF6 3

External Ids for ROPN1 Gene

Previous GeneCards Identifiers for ROPN1 Gene

  • GC03M123636
  • GC03M124969
  • GC03M125008
  • GC03M125170
  • GC03M121061

Summaries for ROPN1 Gene

Entrez Gene Summary for ROPN1 Gene

  • The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for ROPN1 Gene

ROPN1 (Rhophilin Associated Tail Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and RHO GTPases Activate Rhotekin and Rhophilins. An important paralog of this gene is ROPN1B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROPN1 Gene

Genomics for ROPN1 Gene

Regulatory Elements for ROPN1 Gene

Enhancers for ROPN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ROPN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ROPN1 Gene

Chromosome:
3
Start:
123,968,521 bp from pter
End:
123,992,178 bp from pter
Size:
23,658 bases
Orientation:
Minus strand

Genomic View for ROPN1 Gene

Genes around ROPN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ROPN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ROPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROPN1 Gene

Proteins for ROPN1 Gene

  • Protein details for ROPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAT0-ROP1A_HUMAN
    Recommended name:
    Ropporin-1A
    Protein Accession:
    Q9HAT0
    Secondary Accessions:
    • D3DN99
    • Q9UF38

    Protein attributes for ROPN1 Gene

    Size:
    212 amino acids
    Molecular mass:
    23893 Da
    Quaternary structure:
    • Homodimer. Interacts with AKAP3 and RHPN1 (By similarity). May interact with SPA17.
    Miscellaneous:
    • Ropporin comes from the Japanese word oppo which means tail.

    Alternative splice isoforms for ROPN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ROPN1 Gene

Proteomics data for ROPN1 Gene at MOPED

Post-translational modifications for ROPN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ROPN1 Gene

Domains & Families for ROPN1 Gene

Protein Domains for ROPN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ROPN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HAT0

UniProtKB/Swiss-Prot:

ROP1A_HUMAN :
  • The RIIa domain mediates interaction with AKAP3.
  • Belongs to the ropporin family.
Domain:
  • The RIIa domain mediates interaction with AKAP3.
  • Contains 1 RIIa domain.
Family:
  • Belongs to the ropporin family.
genes like me logo Genes that share domains with ROPN1: view

No data available for Gene Families for ROPN1 Gene

Function for ROPN1 Gene

genes like me logo Genes that share phenotypes with ROPN1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ROPN1 Gene

Localization for ROPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ROPN1 Gene

Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath (By similarity). .

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ROPN1 Gene COMPARTMENTS Subcellular localization image for ROPN1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for ROPN1 Gene

Pathways & Interactions for ROPN1 Gene

genes like me logo Genes that share pathways with ROPN1: view

Pathways by source for ROPN1 Gene

Gene Ontology (GO) - Biological Process for ROPN1 Gene

None

No data available for SIGNOR curated interactions for ROPN1 Gene

Drugs & Compounds for ROPN1 Gene

No Compound Related Data Available

Transcripts for ROPN1 Gene

Unigene Clusters for ROPN1 Gene

Rhophilin associated tail protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ROPN1 Gene

No ASD Table

Relevant External Links for ROPN1 Gene

GeneLoc Exon Structure for
ROPN1
ECgene alternative splicing isoforms for
ROPN1

Expression for ROPN1 Gene

mRNA expression in normal human tissues for ROPN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ROPN1 Gene

This gene is overexpressed in Testis (x48.2).

Protein differential expression in normal tissues from HIPED for ROPN1 Gene

This gene is overexpressed in Ovary (35.8) and Testis (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ROPN1 Gene



SOURCE GeneReport for Unigene cluster for ROPN1 Gene Hs.733553

mRNA Expression by UniProt/SwissProt for ROPN1 Gene

Q9HAT0-ROP1A_HUMAN
Tissue specificity: Testis specific in adult. Overexpressed in hematologic tumor cells.
genes like me logo Genes that share expression patterns with ROPN1: view

Protein tissue co-expression partners for ROPN1 Gene

- Elite partner

Primer Products

Orthologs for ROPN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ROPN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ROPN1 35
  • 86.95 (n)
  • 85.38 (a)
ROPN1 36
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC488013 35
  • 88.05 (n)
  • 86.32 (a)
-- 36
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ropn1 35
  • 85.53 (n)
  • 83.49 (a)
Ropn1 16
Ropn1 36
  • 83 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ROPN1 35
  • 99.37 (n)
  • 99.06 (a)
ROPN1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ropn1 35
  • 85.22 (n)
  • 83.96 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4161 36
  • 38 (a)
OneToMany
Species with no ortholog for ROPN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ROPN1 Gene

ENSEMBL:
Gene Tree for ROPN1 (if available)
TreeFam:
Gene Tree for ROPN1 (if available)

Paralogs for ROPN1 Gene

Paralogs for ROPN1 Gene

(2) SIMAP similar genes for ROPN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ROPN1: view

Variants for ROPN1 Gene

Sequence variations from dbSNP and Humsavar for ROPN1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2280422 -- 123,978,083(+) AGTCC(A/G)TTTCA intron-variant
rs2280423 -- 123,978,467(+) AAAGC(C/T)GTAAT intron-variant
rs2292075 -- 123,975,700(+) AGTTA(C/T)CTTTG intron-variant
rs2332715 -- 123,972,164(+) AGCGG(C/G)TTTCA intron-variant
rs2332716 -- 123,972,364(+) TTTTT(A/G)GGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ROPN1 Gene

Variant ID Type Subtype PubMed ID
nsv460837 CNV Gain 19166990
nsv877397 CNV Gain 21882294

Variation tolerance for ROPN1 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ROPN1 Gene

HapMap Linkage Disequilibrium report
ROPN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROPN1 Gene

Disorders for ROPN1 Gene

Relevant External Links for ROPN1

Genetic Association Database (GAD)
ROPN1
Human Genome Epidemiology (HuGE) Navigator
ROPN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ROPN1

No disorders were found for ROPN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ROPN1 Gene

Publications for ROPN1 Gene

  1. A yeast two-hybrid system using Sp17 identified ropporin as a novel cancer-testis antigen in hematologic malignancies. (PMID: 17551920) Li Z. … Lim S.H. (Int. J. Cancer 2007) 3 4 23 67
  2. Kalirin: a novel genetic risk factor for ischemic stroke. (PMID: 20107840) Krug T. … Oliveira S.A. (Hum. Genet. 2010) 3 23
  3. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. (PMID: 11278869) Carr D.W. … Narumiya S. (J. Biol. Chem. 2001) 3 23
  4. Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. (PMID: 10591629) Fujita A. … Narumiya S. (J. Cell. Sci. 2000) 2 3
  5. Ropporin gene expression in infertile asthenozoospermic men with varicocele before and after repair. (PMID: 25704993) Amer M.K. … Mostafa T. (Urology 2015) 3

Products for ROPN1 Gene

Sources for ROPN1 Gene

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