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Aliases for ROPN1 Gene

Aliases for ROPN1 Gene

  • Rhophilin Associated Tail Protein 1 2 3
  • Cancer/Testis Antigen 91 2 3 4
  • Ropporin, Rhophilin Associated Protein 1 2 3
  • Rhophilin-Associated Protein 1A 3 4
  • ROPN1A 3 4
  • ODF6 3 6
  • CT91 3 4
  • Outer Dense Fiber Of Sperm Tails 6 3
  • Ropporin-1A 3
  • Ropporin 3
  • RHPNAP1 3

External Ids for ROPN1 Gene

Previous GeneCards Identifiers for ROPN1 Gene

  • GC03M123636
  • GC03M124969
  • GC03M125008
  • GC03M125170
  • GC03M121061

Summaries for ROPN1 Gene

GeneCards Summary for ROPN1 Gene

ROPN1 (Rhophilin Associated Tail Protein 1) is a Protein Coding gene. GO annotations related to this gene include cAMP-dependent protein kinase regulator activity. An important paralog of this gene is ROPN1B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROPN1 Gene

Genomics for ROPN1 Gene

Regulatory Elements for ROPN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ROPN1 Gene

Start:
123,968,521 bp from pter
End:
123,992,178 bp from pter
Size:
23,658 bases
Orientation:
Minus strand

Genomic View for ROPN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ROPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROPN1 Gene

Proteins for ROPN1 Gene

  • Protein details for ROPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAT0-ROP1A_HUMAN
    Recommended name:
    Ropporin-1A
    Protein Accession:
    Q9HAT0
    Secondary Accessions:
    • D3DN99
    • Q9UF38

    Protein attributes for ROPN1 Gene

    Size:
    212 amino acids
    Molecular mass:
    23893 Da
    Quaternary structure:
    • Homodimer. Interacts with AKAP3 and RHPN1 (By similarity). May interact with SPA17.
    Miscellaneous:
    • Ropporin comes from the Japanese word oppo which means tail

    Alternative splice isoforms for ROPN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ROPN1 Gene

Proteomics data for ROPN1 Gene at MOPED

Post-translational modifications for ROPN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ROPN1 Gene

Domains for ROPN1 Gene

Protein Domains for ROPN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ROPN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HAT0

UniProtKB/Swiss-Prot:

ROP1A_HUMAN :
  • Q9HAT0
Domain:
  • The RIIa domain mediates interaction with AKAP3.
  • Contains 1 RIIa domain.
Family:
  • Belongs to the ropporin family.
genes like me logo Genes that share domains with ROPN1: view

No data available for Gene Families for ROPN1 Gene

Function for ROPN1 Gene

Gene Ontology (GO) - Molecular Function for ROPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17551920
genes like me logo Genes that share ontologies with ROPN1: view

Phenotypes for ROPN1 Gene

MGI mutant phenotypes for ROPN1:
inferred from 1 alleles
GenomeRNAi human phenotypes for ROPN1:
genes like me logo Genes that share phenotypes with ROPN1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ROPN1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ROPN1 Gene

Localization for ROPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ROPN1 Gene

Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath (By similarity). .

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ROPN1 Gene COMPARTMENTS Subcellular localization image for ROPN1 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ROPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IDA 18421703
genes like me logo Genes that share ontologies with ROPN1: view

Pathways for ROPN1 Gene

SuperPathways for ROPN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ROPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ROPN1: view

No data available for Pathways by source for ROPN1 Gene

Transcripts for ROPN1 Gene

Unigene Clusters for ROPN1 Gene

Rhophilin associated tail protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ROPN1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ROPN1 Gene

No ASD Table

Relevant External Links for ROPN1 Gene

GeneLoc Exon Structure for
ROPN1
ECgene alternative splicing isoforms for
ROPN1

Expression for ROPN1 Gene

mRNA expression in normal human tissues for ROPN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ROPN1 Gene

This gene is overexpressed in Testis (48.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ROPN1 Gene

SOURCE GeneReport for Unigene cluster for ROPN1 Gene Hs.733553

mRNA Expression by UniProt/SwissProt for ROPN1 Gene

Q9HAT0-ROP1A_HUMAN
Tissue specificity: Testis specific in adult. Overexpressed in hematologic tumor cells.
genes like me logo Genes that share expressions with ROPN1: view

In Situ Assay Products

Orthologs for ROPN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ROPN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ROPN1 35
  • 99.37 (n)
  • 99.06 (a)
ROPN1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ROPN1 35
  • 86.95 (n)
  • 85.38 (a)
ROPN1 36
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 86 (a)
OneToMany
LOC488013 35
  • 88.05 (n)
  • 86.32 (a)
mouse
(Mus musculus)
Mammalia Ropn1 35
  • 85.53 (n)
  • 83.49 (a)
Ropn1 16
Ropn1 36
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ropn1 35
  • 85.22 (n)
  • 83.96 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4161 36
  • 38 (a)
OneToMany
Species with no ortholog for ROPN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ROPN1 Gene

ENSEMBL:
Gene Tree for ROPN1 (if available)
TreeFam:
Gene Tree for ROPN1 (if available)

Paralogs for ROPN1 Gene

Paralogs for ROPN1 Gene

Selected SIMAP similar genes for ROPN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ROPN1: view

Variants for ROPN1 Gene

Sequence variations from dbSNP and Humsavar for ROPN1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2270987 -- 123,976,437(+) AGAGG(C/T)TCACA intron-variant
rs2280422 -- 123,978,083(+) AGTCC(A/G)TTTCA intron-variant
rs2280423 -- 123,978,467(+) AAAGC(C/T)GTAAT intron-variant
rs2292075 -- 123,975,700(+) AGTTA(C/T)CTTTG intron-variant
rs2332715 -- 123,972,164(+) AGCGG(C/G)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ROPN1 Gene

Variant ID Type Subtype PubMed ID
nsv460837 CNV Gain 19166990
nsv877397 CNV Gain 21882294

Relevant External Links for ROPN1 Gene

HapMap Linkage Disequilibrium report
ROPN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROPN1 Gene

Disorders for ROPN1 Gene

Relevant External Links for ROPN1

Genetic Association Database (GAD)
ROPN1
Human Genome Epidemiology (HuGE) Navigator
ROPN1
genes like me logo Genes that share disorders with ROPN1: view

No data available for UniProtKB/Swiss-Prot for ROPN1 Gene

Publications for ROPN1 Gene

  1. Kalirin: a novel genetic risk factor for ischemic stroke. (PMID: 20107840) Krug T. … Oliveira S.A. (Hum. Genet. 2010) 3 23 48
  2. A yeast two-hybrid system using Sp17 identified ropporin as a novel cancer-testis antigen in hematologic malignancies. (PMID: 17551920) Li Z. … Lim S.H. (Int. J. Cancer 2007) 3 4 23
  3. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. (PMID: 11278869) Carr D.W. … Narumiya S. (J. Biol. Chem. 2001) 3 23
  4. Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. (PMID: 10591629) Fujita A. … Narumiya S. (J. Cell. Sci. 2000) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ROPN1 Gene

Sources for ROPN1 Gene

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