ROPN1 Gene
protein-coding GIFtS: 46
GCID: GC03M123636
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rhophilin associated tail protein 1(Previous names: ropporin, rhophilin associated protein 1 )
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Aliases
for ROPN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rhophilin Associated Tail Protein 11 2 | | Cancer/Testis Antigen 912 3 | | CT911 2 3 | | Rhophilin-Associated Protein 1A2 3 | | ROPN1A1 2 3 | | RHPNAP12 | | ODF61 2 5 | | Outer Dense Fiber Of Sperm Tails 62 | | Ropporin1 | | Ropporin-1A1 | | Ropporin, Rhophilin Associated Protein 11 2 | | |
Export aliases for ROPN1 gene to outside databasesPrevious GC identifers: GC03M124969 GC03M125008 GC03M125170 GC03M121061 |
Summaries
for ROPN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ROPN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ROPN1 gene promoter:
TBP AP-1 MyoD STAT5A Evi-1 GATA-2 MEF-2A CREB aMEF-2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for ROPN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ROPN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21.1 Ensembl cytogenetic band: 3q21.1 HGNC cytogenetic band: 3q21.1ROPN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M123636: view genomic region
(about GC identifiers)
Start:
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123,687,368 bp from pter |
End:
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123,711,025 bp from pter |
Size:
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23,658 bases |
Orientation:
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minus strand |
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Proteins
for ROPN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ROP1A_HUMAN, Q9HAT0 (See
protein sequence)Recommended Name: Ropporin-1A Size: 212 amino acids; 23893 Da
Subunit: Homodimer. Interacts with AKAP3 and RHPN1 (By similarity). May interact with SPA17
Subcellular location: Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located atthe distal end of the midpiece. Inner surface of the fibrous sheath (By similarity)
Developmental stage: Expressed in fetal liver
Miscellaneous: 'Ropporin' comes from the Japanese word 'oppo' which means 'tail'
Secondary accessions: D3DN99 Q9UF38Alternative splicing: 2 isoforms: Q9HAT0-1 Q9HAT0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ROPN1: NX_Q9HAT0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HAT0
ROPN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060048.2
ENSEMBL proteins: ENSP00000184183 ENSP00000418066 ENSP00000385919 ENSP00000417067 ENSP00000420310 ENSP00000417809 ENSP00000418931 ENSP00000420590 ENSP00000420567 ENSP00000418470 ENSP00000419815 ENSP00000417379 ENSP00000419205
Human Recombinant Protein Products:
ROPN1 Antibody Products:
Assay Products for ROPN1: |
Protein
Domains /
Families
for ROPN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ROPN1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9HAT0ProtoNet protein and cluster: Q9HAT0 UniProtKB/Swiss-Prot: ROP1A_HUMAN, Q9HAT0Domain: The RIIa domain mediates interaction with AKAP3 (By similarity)Similarity: Belongs to the ropporin familySimilarity: Contains 1 RIIa domain |
Function
for ROPN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ROPN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ROPN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ROPN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROPN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROPN1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008603 | cAMP-dependent protein kinase regulator activity |
IEA | -- |
ROPN1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ROPN1:
|
Pathways & Interactions
for ROPN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ROPN1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for ROPN1 (Q9HAT03 ENSP000001841834) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- |
ROPN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ROPN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ROPN1
Search CenterWatch for drugs/clinical trials and news about ROPN1 / ROP1A
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Transcripts
for ROPN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ROPN1 gene: NM_017578.2 Unigene Cluster for ROPN1: Rhophilin associated tail protein 1 Hs.733553 [show with all ESTs]Unigene Representative Sequence: BC11100514 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000184183(uc003eha.3) ENST00000484813 ENST00000405845 ENST00000487124
ENST00000467907 ENST00000460743 ENST00000495336 ENST00000496145 ENST00000459660(uc003ehb.2)
ENST00000479867(uc003ehc.2) ENST00000480459 ENST00000498333 ENST00000495093
ENST00000484329
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ROPN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ROPN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ROPN1 (NM_017578) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ROPN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROPN1 |
Additional cDNA sequence: AF303889.2 AK310283.1 BC111005.1 BC132744.1 BC132746.1 4 DOTS entries: DT.441723 DT.97822037 DT.120892359 DT.95169569 23 AceView cDNA sequences: AL037365 BI831090 BI828359 BM554135 BC015413 AF231410 BI830464 BG719672 BG704322 CB989847 BG034740 BM559594 BM552738 BG771571 BG719581 BG719580 BI826006 AA506126 BI560054 BE894254 BI828708 AI016755 CD708847
GeneLoc Exon Structure
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Expression
for ROPN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ROPN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAACAGGAAG
About this image
See ROPN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ROPN1
SOURCE GeneReport for Unigene cluster: Hs.733553
UniProtKB/Swiss-Prot: ROP1A_HUMAN, Q9HAT0Tissue specificity: Testis specific in adult. Overexpressed in hematologic tumor cells
SABiosciences Custom PCR Arrays for ROPN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ROPN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ROPN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ROPN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ROPN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROPN1 |
Orthologs
for ROPN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ROPN1 gene from 1/13 species (see all 13) About this table
ENSEMBL Gene Tree for ROPN1 (if available)
TreeFam Gene Tree for ROPN1 (if available) |
Paralogs
for ROPN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ROPN1 gene
- ROPN1L2 ROPN1B2
2 SIMAP similar genes for ROPN1 using alignment to 7 protein entries: ROP1A_HUMAN (see all proteins):ROPN1B ROPN1L
ROPN1 for paralogs About GeneDecksing
|
Genomic Variants
for ROPN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ROPN1 (123687368 - 123711025 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ROPN1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ROPN1 |
|
Disorders
/ Diseases
for ROPN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ROPN1 for disorders About GeneDecksing
OMIM gene information: 611757
OMIM disorders: --
2  diseases for ROPN1: About MalaCardsmultiple myeloma myeloma
Human Genome Epidemiology (HuGE) Navigator: ROPN1 (1 document)
Export disorders for ROPN1 gene to outside databases
|
Publications
for ROPN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ROPN1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ROPN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A yeast two-hybrid system using Sp17 identified ropporin as a novel cancer-testis antigen in hematologic malignancies. (PubMed id 17551920)1, 2, 9 Li Z.... Lim S.H. (2007)
- Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. (PubMed id 10591629)1, 3 Fujita A....Narumiya S. (2000)
- Kalirin: a novel genetic risk factor for ischemic str oke. (PubMed id 20107840)1, 9 Krug T....Oliveira S.A. (2010)
- Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. (PubMed id 11278869)1, 9 Carr D.W....Narumiya S. (2001)
- Loss of ASP but not ROPN1 reduces mammalian ciliary mo tility. (PubMed id 22021175)1 Fiedler S.E....Carr D.W. (2012)
- CABYR binds to AKAP3 and Ropporin in the human sperm fibrous sheath. (PubMed id 21240291)1 Li Y.F....Herr J.C. (2011)
- Cancer testis antigen, ropporin, is a potential targe t for multiple myeloma immunotherapy. (PubMed id 21654522)1 Chiriva-Internati M....Cobos E. (2011)
- Functional expression of ropporin in human testis and ejaculated spermatozoa. (PubMed id 20705794)1 Chen J....Cai Z. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for ROPN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ROPN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ROPN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ROPN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ROPN1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ROPN1 gene:
Search GeneIP for patents involving ROPN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ROPN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ROPN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ROPN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ROPN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ROPN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ROPN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ROPN1 |
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 | | | ROPN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROPN1 |
|  |  |  | | | | Search ThermoFisher Antibodies for ROPN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROPN1 |
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