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Aliases for ROMO1 Gene

Aliases for ROMO1 Gene

  • Reactive Oxygen Species Modulator 1 2 3 5
  • Mitochondrial Targeting GxxxG Motif Protein 3 4
  • Mitochondrial Targeting GXXXG Protein 2 3
  • Epididymis Tissue Protein Li 175 3 4
  • Protein MGR2 Homolog 3 4
  • ROS Modulator 1 3 4
  • Glyrichin 3 4
  • C20orf52 3 4
  • MTGM 3 4
  • Chromosome 20 Open Reading Frame 52 2
  • BA353C18.2 3
  • MTGMP 3
  • PCM19 3

External Ids for ROMO1 Gene

Previous HGNC Symbols for ROMO1 Gene

  • C20orf52

Previous GeneCards Identifiers for ROMO1 Gene

  • GC20P033751
  • GC20P034288
  • GC20P031064

Summaries for ROMO1 Gene

Entrez Gene Summary for ROMO1 Gene

  • The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014]

GeneCards Summary for ROMO1 Gene

ROMO1 (Reactive Oxygen Species Modulator 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ROMO1 Gene

  • Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.

  • Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROMO1 Gene

Genomics for ROMO1 Gene

Regulatory Elements for ROMO1 Gene

Enhancers for ROMO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F035659 0.2 ENCODE 11.5 -36.4 -36440 5.9 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CPNE1 NCOA6 RBM12 EIF6 ROMO1 NFS1 TRPC4AP PHF20 RPL36P4 CEP250
GH20F035658 0.9 Ensembl ENCODE 11.2 -40.3 -40340 1.2 SMARCE1 NR2F1 DPF2 CEBPG ATF2 ZNF121 FOSL1 RAD51 IKZF1 TRIM24 NFS1 ROMO1 CEP250 GDF5 MIR1289-1 PHF20 RBM39 CPNE1 RBM12 RNU6-759P
GH20F035854 0.2 ENCODE 11 +155.6 155602 0.2 TBP HLF CEBPA CEBPG EP300 CPNE1 PHF20 RPF2P1 RBM39 RNU4-40P RNU6-937P NFS1 ROMO1 ENSG00000199676 GC20M035854
GH20F035855 0.7 ENCODE 11 +156.0 155962 0.2 TBP CEBPB EP300 CHD2 CPNE1 RNU4-40P PHF20 NFS1 ROMO1 RNU6-937P ENSG00000199676 GC20M035854 HIGD1AP16
GH20F035856 0.5 ENCODE 11 +157.8 157765 1.2 ZNF362 STAT1 ZBTB33 CPNE1 RNU4-40P PHF20 NFS1 ROMO1 RNU6-937P ENSG00000199676 GC20M035854 HIGD1AP16
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ROMO1 on UCSC Golden Path with GeneCards custom track

Promoters for ROMO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000400329 228 2201 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for ROMO1 Gene

Chromosome:
20
Start:
35,699,272 bp from pter
End:
35,700,984 bp from pter
Size:
1,713 bases
Orientation:
Plus strand

Genomic View for ROMO1 Gene

Genes around ROMO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ROMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ROMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROMO1 Gene

Proteins for ROMO1 Gene

  • Protein details for ROMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60602-ROMO1_HUMAN
    Recommended name:
    Reactive oxygen species modulator 1
    Protein Accession:
    P60602
    Secondary Accessions:
    • A7M872
    • E1P5R9
    • E9KL28
    • Q3MHD5
    • Q5QP16
    • Q9CQ98
    • Q9H1N2

    Protein attributes for ROMO1 Gene

    Size:
    79 amino acids
    Molecular mass:
    8183 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Enforced expression in IMR-90 cells leads to increased levels of ROS and induces premature cell senescence and nuclear DNA damage.

    Alternative splice isoforms for ROMO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ROMO1 Gene

Post-translational modifications for ROMO1 Gene

No Post-translational modifications

Other Protein References for ROMO1 Gene

No data available for DME Specific Peptides for ROMO1 Gene

Domains & Families for ROMO1 Gene

Protein Domains for ROMO1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ROMO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60602

UniProtKB/Swiss-Prot:

ROMO1_HUMAN :
  • Belongs to the MGR2 family.
Family:
  • Belongs to the MGR2 family.
genes like me logo Genes that share domains with ROMO1: view

No data available for Gene Families for ROMO1 Gene

Function for ROMO1 Gene

Molecular function for ROMO1 Gene

UniProtKB/Swiss-Prot Function:
Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
UniProtKB/Swiss-Prot Function:
Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
UniProtKB/Swiss-Prot Induction:
By the anticancer drug fluorouracil (5FU).

Gene Ontology (GO) - Molecular Function for ROMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with ROMO1: view

Phenotypes for ROMO1 Gene

genes like me logo Genes that share phenotypes with ROMO1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ROMO1 Gene

Localization for ROMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ROMO1 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ROMO1 Gene COMPARTMENTS Subcellular localization image for ROMO1 gene
Compartment Confidence
mitochondrion 5
extracellular 3

Gene Ontology (GO) - Cellular Components for ROMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 16842742
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ROMO1: view

Pathways & Interactions for ROMO1 Gene

SuperPathways for ROMO1 Gene

No Data Available

Interacting Proteins for ROMO1 Gene

Gene Ontology (GO) - Biological Process for ROMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001302 replicative cell aging IMP 18836179
GO:0008284 positive regulation of cell proliferation IDA 18313394
GO:0034614 cellular response to reactive oxygen species IMP 18836179
GO:0042742 defense response to bacterium IEA --
GO:2000379 positive regulation of reactive oxygen species metabolic process IDA 16842742
genes like me logo Genes that share ontologies with ROMO1: view

No data available for Pathways by source and SIGNOR curated interactions for ROMO1 Gene

Transcripts for ROMO1 Gene

Unigene Clusters for ROMO1 Gene

Reactive oxygen species modulator 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ROMO1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: -
SP3:

Relevant External Links for ROMO1 Gene

GeneLoc Exon Structure for
ROMO1
ECgene alternative splicing isoforms for
ROMO1

Expression for ROMO1 Gene

mRNA expression in normal human tissues for ROMO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ROMO1 Gene

This gene is overexpressed in Retina (11.0), Testis (10.3), Pancreas (9.6), and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ROMO1 Gene



Protein tissue co-expression partners for ROMO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ROMO1 Gene:

ROMO1

SOURCE GeneReport for Unigene cluster for ROMO1 Gene:

Hs.472564

mRNA Expression by UniProt/SwissProt for ROMO1 Gene:

P60602-ROMO1_HUMAN
Tissue specificity: Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line. Highly expressed in brain tumors.
genes like me logo Genes that share expression patterns with ROMO1: view

Primer Products

No data available for mRNA differential expression in normal tissues for ROMO1 Gene

Orthologs for ROMO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ROMO1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia ROMO1 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ROMO1 34 35
  • 99.16 (n)
cow
(Bos Taurus)
Mammalia ROMO1 34 35
  • 95.78 (n)
dog
(Canis familiaris)
Mammalia ROMO1 34 35
  • 94.09 (n)
mouse
(Mus musculus)
Mammalia Romo1 34 16 35
  • 93.25 (n)
rat
(Rattus norvegicus)
Mammalia Romo1 34
  • 92.41 (n)
chicken
(Gallus gallus)
Aves ROMO1 34 35 35
  • 83.54 (n)
lizard
(Anolis carolinensis)
Reptilia ROMO1 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia romo1 34
  • 80.59 (n)
zebrafish
(Danio rerio)
Actinopterygii ROMO1 35
  • 89 (a)
OneToOne
zgc:73345 34
  • 79.75 (n)
zgc73345 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9814 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012145 34
  • 72.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6878 34 35
  • 65.4 (n)
worm
(Caenorhabditis elegans)
Secernentea rmo-1 35
  • 49 (a)
OneToMany
Y94A7B.11 35
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MGR2 37 37
Species where no ortholog for ROMO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ROMO1 Gene

ENSEMBL:
Gene Tree for ROMO1 (if available)
TreeFam:
Gene Tree for ROMO1 (if available)

Paralogs for ROMO1 Gene

Pseudogenes.org Pseudogenes for ROMO1 Gene

genes like me logo Genes that share paralogs with ROMO1: view

No data available for Paralogs for ROMO1 Gene

Variants for ROMO1 Gene

Sequence variations from dbSNP and Humsavar for ROMO1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1044521 -- 35,699,714(+) GTTGC(C/G)CCGTG upstream-variant-2KB, reference, missense
rs112882026 -- 35,698,188(+) GTTTA(A/G)TACTT intron-variant, upstream-variant-2KB
rs116600599 -- 35,697,372(+) TGGTA(A/G)TAAAC intron-variant, upstream-variant-2KB
rs12479454 -- 35,698,688(+) GTGAG(A/G)TAAGT intron-variant, upstream-variant-2KB
rs13036871 -- 35,701,347(+) gtgca(G/T)tggca downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ROMO1 Gene

Variant ID Type Subtype PubMed ID
nsv526188 CNV gain 19592680

Variation tolerance for ROMO1 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ROMO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ROMO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROMO1 Gene

Disorders for ROMO1 Gene

Relevant External Links for ROMO1

Genetic Association Database (GAD)
ROMO1
Human Genome Epidemiology (HuGE) Navigator
ROMO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ROMO1

No disorders were found for ROMO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ROMO1 Gene

Publications for ROMO1 Gene

  1. A critical role for Romo1-derived ROS in cell proliferation. (PMID: 18313394) Na A.R. … Yoo Y.D. (Biochem. Biophys. Res. Commun. 2008) 2 3 4 64
  2. Drug resistance to 5-FU linked to reactive oxygen species modulator 1. (PMID: 17537404) Hwang I.T. … Yoo Y.D. (Biochem. Biophys. Res. Commun. 2007) 2 3 4 64
  3. A novel protein, Romo1, induces ROS production in the mitochondria. (PMID: 16842742) Chung Y.M. … Yoo Y.D. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 64
  4. Antibacterial potential of hGlyrichin encoded by a human gene. (PMID: 22083756) Sha J. … Wang Z. (J. Pept. Sci. 2012) 3 4 64
  5. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J. … Liu Y. (Mol. Cell. Proteomics 2010) 3 4 64

Products for ROMO1 Gene

Sources for ROMO1 Gene

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