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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ROMO1 Gene

protein-coding   GIFtS: 46
GCID: GC20P034288

Reactive Oxygen Species Modulator 1

(Previous name: chromosome 20 open reading frame 52)
(Previous symbol: C20orf52)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Reactive Oxygen Species Modulator 11 2     ROS Modulator 12 3
C20orf521 2 3     Chromosome 20 Open Reading Frame 521
Mitochondrial Targeting GXXXG Protein1 2     MTGMP2
Epididymis Tissue Protein Li 1752 3     bA353C18.22
Mitochondrial Targeting GxxxG Motif Protein2 3     glyrichin2
Protein MGR2 Homolog2 3     Glyrichin3
MTGM2 3     

External Ids:    HGNC: 161851   Entrez Gene: 1408232   Ensembl: ENSG000001259957   UniProtKB: P606023   

Export aliases for ROMO1 gene to outside databases

Previous GC identifers: GC20P033751 GC20P031064


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ROMO1 Gene: 
ROMO1 (reactive oxygen species modulator 1) is a protein-coding gene. Diseases associated with ROMO1 include epididymitis, and hemoglobinuria. GO annotations related to this gene include molecular_function.

UniProtKB/Swiss-Prot: ROMO1_HUMAN, P60602
Function: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play
a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of
mitochondrial morphology and cell proliferation
Function: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and
M.tuberculosis. Acts by inducing bacterial membrane breakage




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ROMO1 gene promoter:
         GR   TBP   Pbx1a   AML1a   NF-kappaB   C/EBPalpha   ZIC2/Zic2   Msx-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidROMO1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ROMO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ROMO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.22

ROMO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ROMO1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P034288:  view genomic region     (about GC identifiers)

Start:
34,287,194 bp from pter      End:
34,288,906 bp from pter
Size:
1,713 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ROMO1_HUMAN, P60602 (See protein sequence)
Recommended Name: Reactive oxygen species modulator 1  
Size: 79 amino acids; 8183 Da
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein
Developmental stage: Expression increases in senescent cells
Miscellaneous: Enforced expression in IMR-90 cells leads to increased levels of ROS and induces premature cell
senescence and nuclear DNA damage
Secondary accessions: A7M872 E1P5R9 E9KL28 Q3MHD5 Q5QP16 Q9CQ98 Q9H1N2
Alternative splicing: 2 isoforms:  P60602-1   P60602-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ROMO1: NX_P60602

Explore proteomics data for ROMO1 at MOPED 

ROMO1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ROMO1 Protein Expression

REFSEQ proteins: NP_542786.1  
ENSEMBL proteins: 
 ENSP00000363191   ENSP00000363190   ENSP00000363185   ENSP00000380561   ENSP00000338293  

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA16842742
GO:0005743mitochondrial inner membrane IEA--
GO:0016021integral to membrane IEA--

ROMO1 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for ROMO1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR018450 Romo1

Graphical View of Domain Structure for InterPro Entry P60602

ProtoNet protein and cluster: P60602

UniProtKB/Swiss-Prot: ROMO1_HUMAN, P60602
Similarity: Belongs to the MGR2 family


ROMO1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ROMO1_HUMAN, P60602
Function: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play
a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of
mitochondrial morphology and cell proliferation
Function: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and
M.tuberculosis. Acts by inducing bacterial membrane breakage
Induction: By the anticancer drug fluorouracil (5FU)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
     
ROMO1 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for ROMO1 
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ROMO1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ROMO1 

miRNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROMO1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ROMO1

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/8 Interacting proteins for ROMO1 (ENSP000003382934) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
HSP90AB1ENSP000003258754STRING: ENSP00000325875
LETM1ENSP000003056534STRING: ENSP00000305653
HSP90AA1ENSP000003351534STRING: ENSP00000335153
TIMM23ENSP000002608674STRING: ENSP00000260867
AFG3L2ENSP000002691434STRING: ENSP00000269143
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001302replicative cell aging IMP18836179
GO:0008284positive regulation of cell proliferation IDA18313394
GO:0034614cellular response to reactive oxygen species IMP18836179
GO:0042742defense response to bacterium IEA--
GO:2000379positive regulation of reactive oxygen species metabolic process IDA16842742

ROMO1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ROMO1

Search CenterWatch for drugs/clinical trials and news about ROMO1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ROMO1 gene: 
NM_080748.2  

Unigene Cluster for ROMO1:

Reactive oxygen species modulator 1
Hs.472564  [show with all ESTs]
Unigene Representative Sequence: CD356770
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000374078(uc002xdy.3 uc010gfm.3) ENST00000374077 ENST00000374072
ENST00000397416 ENST00000336695
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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hsa-miR-888
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Inhib. RNA
Products:
     
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ROMO1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ROMO1

Additional mRNA sequence: 

AK000548.1 AM397244.1 AM397245.1 AM397246.1 BC008488.1 BC105281.1 GU727625.1 

16 DOTS entries:

DT.99939286  DT.448921  DT.100819124  DT.120831274  DT.100060713  DT.453288  DT.120831356  DT.91697346 
DT.100039621  DT.120831329  DT.40132961  DT.91743144  DT.120831224  DT.95090149  DT.120831312  DT.434997 

24/262 AceView cDNA sequences (see all 262):

BM464228 BG528444 BM852446 BI827456 AI570484 BU782836 F16645 AA862646 
BU957011 AA947450 AJ346181 AI697073 BQ927534 BQ640235 AJ346545 AA372310 
BM353595 BF217239 AK000548 AJ346424 BM664744 BQ921676 AA327677 AI290866 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ROMO1    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1:              -                           
SP2:              -                           
SP3:                                          


ECgene alternative splicing isoforms for ROMO1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ROMO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TACTAATAAA
ROMO1 Expression
About this image


See ROMO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ROMO1

SOURCE GeneReport for Unigene cluster: Hs.472564

UniProtKB/Swiss-Prot: ROMO1_HUMAN, P60602
Tissue specificity: Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell
line. Highly expressed in brain tumors

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROMO1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for ROMO1 gene from 7/14 species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Romo11 , 5 reactive oxygen species modulator 11, 5 93.25(n)1
100(a)1
  2 (77.36 cM)5
670671  NM_001164216.11  NP_001157688.11 
 1561440395 
chicken
(Gallus gallus)
Aves ROMO11 reactive oxygen species modulator 1 83.54(n)
96.2(a)
  768833  NM_001198821.1  NP_001185750.1 
lizard
(Anolis carolinensis)
Reptilia ROMO16
Uncharacterized protein
95(a)
1 ↔ 1
4(134432790-134434109)
zebrafish
(Danio rerio)
Actinopterygii zgc733452 hypothetical protein MGC73345 79.52(n)   393770  BC059661.1 
fruit fly
(Drosophila melanogaster)
Insecta CG68781 CG6878 65.4(n)
62.03(a)
  39656  NM_140500.2  NP_648757.1 
worm
(Caenorhabditis elegans)
Secernentea rmo-16
Protein RMO-1
50(a)
1 ↔ 1
II(13237405-13237908)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MGR2(YPL098C)4 Protein required for growth of cells lacking the mitochondrial more   --   16(364727-364386) 856006  NP_015227.1 


ENSEMBL Gene Tree for ROMO1 (if available)
TreeFam Gene Tree for ROMO1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ROMO1 gene

ROMO1 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for ROMO1
PGOHUM00000243943 PGOHUM00000244643


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

2 SNPs in ROMO1 are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0141274
----see VAR_0141272 A P mis40--------
rs1828440211,2
--34289308(+) CCTGTA/GTTCAA 1 -- ds50010--------

HapMap Linkage Disequilibrium report for ROMO1 (34287194 - 34288906 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for ROMO1:    About this table     
Variant IDTypeSubtypePubMed ID
nsv526188CNV Gain19592680

SABiosciences Cancer Mutation PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for ROMO1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
3 diseases for ROMO1:    About MalaCards
epididymitis    hemoglobinuria    tuberculosis


ROMO1 for disorders           About GeneDecksing

Genetic Association Database (GAD): ROMO1
Human Genome Epidemiology (HuGE) Navigator: ROMO1 (1 document)

Export disorders for ROMO1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ROMO1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with ROMO1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A critical role for Romo1-derived ROS in cell proliferation. (PubMed id 18313394)1, 2, 3 Na A.R.... Yoo Y.D. (2008)
  2. Drug resistance to 5-FU linked to reactive oxygen species modulator 1. (PubMed id 17537404)1, 2, 3 Hwang I.T....Yoo Y.D. (2007)
  3. A novel protein, Romo1, induces ROS production in the mitochondria. (PubMed id 16842742)1, 2, 3 Chung Y.M.... Yoo Y.D. (2006)
  4. Antibacterial potential of hGlyrichin encoded by a human gene. (PubMed id 22083756)1, 2 Sha J.... Wang Z. (2011)
  5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
  6. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (2010)
  7. The novel conserved mitochondrial inner-membrane prot ein MTGM regulates mitochondrial morphology and cell proliferation. (PubMed id 19535734)1, 2 Zhao J....NistAcr M. (2009)
  8. Replicative senescence induced by Romo1-derived reactive oxygen species. (PubMed id 18836179)1, 2 Chung Y.M....Yoo Y.D. (2008)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 140823 HGNC: 16185 AceView: C20orf52 Ensembl:ENSG00000125995 euGenes: HUgn140823
ECgene: ROMO1 H-InvDB: ROMO1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ROMO1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ROMO1 gene:
Search GeneIP for patents involving ROMO1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore Custom Antibody & Bulk Services
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 Regulatory tfbs in ROMO1 promoter
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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