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ROMO1 Gene

protein-coding   GIFtS: 48
GCID: GC20P034288

Reactive Oxygen Species Modulator 1

(Previous name: chromosome 20 open reading frame 52)
(Previous symbol: C20orf52)
  Search for ROMO1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Reactive Oxygen Species Modulator 11 2     ROS Modulator 12 3
C20orf521 2 3     Chromosome 20 Open Reading Frame 521
Mitochondrial Targeting GXXXG Protein1 2     MTGMP2
Epididymis Tissue Protein Li 1752 3     bA353C18.22
Mitochondrial Targeting GxxxG Motif Protein2 3     glyrichin2
Protein MGR2 Homolog2 3     Glyrichin3
MTGM2 3     

External Ids:    HGNC: 161851   Entrez Gene: 1408232   Ensembl: ENSG000001259957   UniProtKB: P606023   
ORGUL members:         

Export aliases for ROMO1 gene to outside databases

Previous GC identifers: GC20P033751 GC20P031064


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ROMO1 Gene:
ROMO1 (reactive oxygen species modulator 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: ROMO1_HUMAN, P60602
Function: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play
a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of
mitochondrial morphology and cell proliferation
Function: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and
M.tuberculosis. Acts by inducing bacterial membrane breakage




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the ROMO1 gene promoter:
         GR   TBP   Pbx1a   AML1a   NF-kappaB   C/EBPalpha   ZIC2/Zic2   Msx-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidROMO1 promoter sequence
   Search Chromatin IP Primers for ROMO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ROMO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.22

ROMO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ROMO1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P034288:  view genomic region     (about GC identifiers)

Start:
34,287,194 bp from pter      End:
34,288,906 bp from pter
Size:
1,713 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ROMO1_HUMAN, P60602 (See protein sequence)
Recommended Name: Reactive oxygen species modulator 1  
Size: 79 amino acids; 8183 Da
Developmental stage: Expression increases in senescent cells
Miscellaneous: Enforced expression in IMR-90 cells leads to increased levels of ROS and induces premature cell
senescence and nuclear DNA damage
Secondary accessions: A7M872 E1P5R9 E9KL28 Q3MHD5 Q5QP16 Q9CQ98 Q9H1N2
Alternative splicing: 2 isoforms:  P60602-1   P60602-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ROMO1: NX_P60602

Explore proteomics data for ROMO1 at MOPED


See ROMO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_542786.1  
ENSEMBL proteins: 
 ENSP00000363191   ENSP00000363190   ENSP00000363185   ENSP00000380561   ENSP00000338293  

ROMO1 Human Recombinant Protein Products:

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ROMO1 Antibody Products:

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LSBio Antibodies in human, mouse, rat for ROMO1

ROMO1 Assay Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR018450 Romo1

Graphical View of Domain Structure for InterPro Entry P60602

ProtoNet protein and cluster: P60602

UniProtKB/Swiss-Prot: ROMO1_HUMAN, P60602
Similarity: Belongs to the MGR2 family


Find genes that share domains with ROMO1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ROMO1_HUMAN, P60602
Function: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play
a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of
mitochondrial morphology and cell proliferation
Function: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and
M.tuberculosis. Acts by inducing bacterial membrane breakage
Induction: By the anticancer drug fluorouracil (5FU)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
     
Find genes that share ontologies with ROMO1           About GenesLikeMe


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ROMO1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ROMO1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ROMO1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ROMO1

miRNA
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1 qRT-PCR Assays for microRNA that regulate ROMO1:
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Inhib. RNA
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for ROMO1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROMO1

Cell Line
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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ROMO1_HUMAN, P60602: Mitochondrion inner membrane; Single-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
extracellular3
nucleus1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA16842742
GO:0005743mitochondrial inner membrane IEA--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with ROMO1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ROMO1
Interactions:

    Search GeneGlobe Interaction Network for ROMO1

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

Selected Interacting proteins for ROMO1 (ENSP000003382934) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
InteractantInteraction Details
GeneCardExternal ID(s)
IMMTENSP000003872624STRING: ENSP00000387262
OMA1ENSP000003602704STRING: ENSP00000360270
TIMM21ENSP000001695514STRING: ENSP00000169551
LETM1ENSP000003056534STRING: ENSP00000305653
LETM2ENSP000002977204STRING: ENSP00000297720
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001302replicative cell aging IMP18836179
GO:0008284positive regulation of cell proliferation IDA18313394
GO:0034614cellular response to reactive oxygen species IMP18836179
GO:0042742defense response to bacterium IEA--
GO:2000379positive regulation of reactive oxygen species metabolic process IDA16842742

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ROMO1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ROMO1 gene: 
NM_080748.2  

Unigene Cluster for ROMO1:

Reactive oxygen species modulator 1
Hs.472564  [show with all ESTs]
Unigene Representative Sequence: CD356770
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000374078(uc002xdy.3 uc010gfm.3) ENST00000374077 ENST00000374072
ENST00000397416 ENST00000336695
miRNA
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1 qRT-PCR Assays for microRNA that regulate ROMO1:
hsa-miR-888
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat ROMO1
Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ROMO1 (NM_080748)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROMO1
Primer
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OriGene qPCR primer pairs and template standards for ROMO1
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ROMO1
  QuantiTect SYBR Green Assays in human, mouse, rat ROMO1
  QuantiFast Probe-based Assays in human, mouse, rat ROMO1

Additional mRNA sequence: 

AK000548.1 AM397244.1 AM397245.1 AM397246.1 BC008488.1 BC105281.1 GU727625.1 

16 DOTS entries:

DT.99939286  DT.448921  DT.100819124  DT.120831274  DT.100060713  DT.453288  DT.120831356  DT.91697346 
DT.100039621  DT.120831329  DT.40132961  DT.91743144  DT.120831224  DT.95090149  DT.120831312  DT.434997 

Selected AceView cDNA sequences (see all 262):

BM709861 AA947450 AJ346072 BQ640235 AI016688 BC008488 BU734222 AA327677 
BQ927534 BU782836 AA057886 BM664744 AA372310 F36607 BQ921676 AL702780 
AA707377 F30525 NM_080748 AA862646 CD677456 F25443 BU957011 AK000548 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ROMO1    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1:              -                           
SP2:              -                           
SP3:                                          


ECgene alternative splicing isoforms for ROMO1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ROMO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TACTAATAAA
ROMO1 Expression
About this image


ROMO1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 12) fully expand
 
 Bone (Muscoskeletal System)
         Bone Marrow
 
 Colon (Gastrointestinal Tract)
 
 Kidney (Urinary System)
 
 Testis (Reproductive System)
 
 Adipose (Muscoskeletal System)
ROMO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ROMO1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.472564

UniProtKB/Swiss-Prot: ROMO1_HUMAN, P60602
Tissue specificity: Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell
line. Highly expressed in brain tumors

    Custom PCR Arrays for ROMO1
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QuantiFast Probe-based Assays in human, mouse, rat ROMO1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROMO1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ROMO1 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Romo11 , 5 reactive oxygen species modulator 11, 5 93.25(n)1
100(a)1
  2 (77.36 cM)5
670671  NM_025946.61  NP_080222.11 
 1561440395 
chicken
(Gallus gallus)
Aves ROMO11 reactive oxygen species modulator 1 83.54(n)
96.2(a)
  768833  NM_001198821.1  NP_001185750.1 
lizard
(Anolis carolinensis)
Reptilia ROMO16
reactive oxygen species modulator 1
95(a)
1 ↔ 1
4(134432790-134434109)
tropical clawed frog
(Xenopus tropicalis)
Amphibia romo11 reactive oxygen species modulator 1 80.59(n)
94.94(a)
  100125151  NM_001171646.1  NP_001165117.1 
zebrafish
(Danio rerio)
Actinopterygii zgc733452 hypothetical protein MGC73345 79.52(n)   393770  BC059661.1 
fruit fly
(Drosophila melanogaster)
Insecta CG68781 CG6878 65.4(n)
62.03(a)
  39656  NM_140500.3  NP_648757.1 
worm
(Caenorhabditis elegans)
Secernentea rmo-16
Y94A7B.116
Protein Y94A7B.11 (Y94A7B.11) mRNA, complete cds
49(a)
32(a)
many → 1
many → 1
II(13237405-13237908) WBGene00008860
V(17802410-17802619) WBGene00050893


ENSEMBL Gene Tree for ROMO1 (if available)
TreeFam Gene Tree for ROMO1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ROMO1 gene

Find genes that share paralogs with ROMO1           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for ROMO1
PGOHUM00000243943 PGOHUM00000244643


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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2 SNPs for ROMO1    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1828440211,2
--34289308(+) CCTGTA/GTTCAA 1 -- ds50010--------
rs10445211,2,4
----see VAR_0141272 mis40--------

HapMap Linkage Disequilibrium report for ROMO1 (34287194 - 34288906 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for ROMO1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv526188CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing ROMO1
DNA2.0 Custom Variant and Variant Library Synthesis for ROMO1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with ROMO1           About GenesLikeMe

Genetic Association Database (GAD): ROMO1
Human Genome Epidemiology (HuGE) Navigator: ROMO1 (1 document)

Export disorders for ROMO1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ROMO1 gene, integrated from 10 sources (see all 20):
(articles sorted by number of sources associating them with ROMO1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A critical role for Romo1-derived ROS in cell proliferation. (PubMed id 18313394)1, 2, 3 Na A.R.... Yoo Y.D. (Biochem. Biophys. Res. Commun. 2008)
  2. Drug resistance to 5-FU linked to reactive oxygen species modulator 1. (PubMed id 17537404)1, 2, 3 Hwang I.T.... Yoo Y.D. (Biochem. Biophys. Res. Commun. 2007)
  3. A novel protein, Romo1, induces ROS production in the mitochondria. (PubMed id 16842742)1, 2, 3 Chung Y.M.... Yoo Y.D. (Biochem. Biophys. Res. Commun. 2006)
  4. Antibacterial potential of hGlyrichin encoded by a human gene. (PubMed id 22083756)1, 2 Sha J.... Wang Z. (J. Pept. Sci. 2012)
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  6. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (Mol. Cell. Proteomics 2010)
  7. The novel conserved mitochondrial inner-membrane protein MTGM regulates mitochondrial morphology and cell proliferation. (PubMed id 19535734)1, 2 Zhao J.... Nister M. (J. Cell Sci. 2009)
  8. Replicative senescence induced by Romo1-derived reactive oxygen species. (PubMed id 18836179)1, 2 Chung Y.M....Yoo Y.D. (J. Biol. Chem. 2008)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 140823 HGNC: 16185 AceView: C20orf52 Ensembl:ENSG00000125995 euGenes: HUgn140823
ECgene: ROMO1 H-InvDB: ROMO1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ROMO1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ROMO1 gene:
Search GeneIP for patents involving ROMO1

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore genomic analysis products

  
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 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for ROMO1   OriGene RNAi products in human, mouse, rat for ROMO1  
 OriGene qPCR primer pairs and template standards for ROMO1   OriGene Protein Over-expression Lysate for ROMO1  
 OriGene MassSpec something-or-other for ROMO1   OriGene clones in human, mouse for ROMO1  
 OriGene qSTAR qPCR primer pairs in human, mouse for ROMO1   OriGene Purified Protein for ROMO1  
 OriGene ORF clones in mouse, rat for ROMO1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for ROMO1   OriGene Custom Protein Services for ROMO1  

 
 
 Block miRNA regulation of human, mouse, rat ROMO1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ROMO1
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ROMO1 Predesigned siRNA for gene silencing in human, mouse, rat ROMO1
 QuantiFast Probe-based Assays in human, mouse, rat ROMO1 QuantiTect SYBR Green Assays in human, mouse, rat ROMO1
 Custom PCR Arrays for ROMO1 Search Chromatin IP Primers for ROMO1
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ROMO1  Search GeneGlobe Interaction Network for ROMO1
 Regulatory tfbs in ROMO1 promoter
 GenScript Custom Purified and Recombinant Proteins Services for ROMO1 GenScript cDNA clones with any tag delivered in your preferred vector for ROMO1
 GenScript Custom Assay Services for ROMO1 GenScript Custom overexpressing Cell Line Services for ROMO1
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for ROMO1
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 ROMO1 antibodies
 ROMO1 proteins
 Antibodies for ROMO1
 See all of Abcam's Antibodies, Kits and Proteins for ROMO1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for ROMO1
 Antibodies for ROMO1
 ELISAs for ROMO1
 CLIAs for ROMO1



 Browse ESI BIO Cell Lines and PureStem Progenitors for ROMO1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROMO1
 Browse SwitchGear 3'UTR luciferase reporter plasmids for ROMO1
 SwitchGear Promoter luciferase reporter plasmids for ROMO1
 Search ThermoFisher Antibodies for ROMO1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROMO1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ROMO1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ROMO1
 LSBio Antibodies in human, mouse, rat for ROMO1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for ROMO1
  Search eBioscience for proteins for ROMO1
  Search eBioscience for elisas for ROMO1
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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