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Aliases for ROMO1 Gene

Aliases for ROMO1 Gene

  • Reactive Oxygen Species Modulator 1 2 3 5
  • Mitochondrial Targeting GxxxG Motif Protein 3 4
  • Mitochondrial Targeting GXXXG Protein 2 3
  • Epididymis Tissue Protein Li 175 3 4
  • Protein MGR2 Homolog 3 4
  • ROS Modulator 1 3 4
  • Glyrichin 3 4
  • C20orf52 3 4
  • MTGM 3 4
  • Chromosome 20 Open Reading Frame 52 2
  • BA353C18.2 3
  • MTGMP 3
  • PCM19 3

External Ids for ROMO1 Gene

Previous HGNC Symbols for ROMO1 Gene

  • C20orf52

Previous GeneCards Identifiers for ROMO1 Gene

  • GC20P033751
  • GC20P034288
  • GC20P031064

Summaries for ROMO1 Gene

Entrez Gene Summary for ROMO1 Gene

  • The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014]

GeneCards Summary for ROMO1 Gene

ROMO1 (Reactive Oxygen Species Modulator 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ROMO1 Gene

  • Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.

  • Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.

Additional gene information for ROMO1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROMO1 Gene

Genomics for ROMO1 Gene

Regulatory Elements for ROMO1 Gene

Enhancers for ROMO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H035874 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +176.2 176246 2 PKNOX1 ATF1 ARNT SIN3A FEZF1 BRCA1 ZNF2 GTF3C2 KLF7 ATF7 CPNE1 RBM39 RBM12 ERGIC3 RPL36P4 TRPC4AP NFS1 EIF6 DSN1 AAR2
GH20H035881 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +184.5 184514 4 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 GTF3C2 ZNF121 ELK1 ZNF143 CPNE1 RBM39 RBM12 ERGIC3 RPL36P4 TRPC4AP EIF6 DSN1 AAR2 RNU6-937P
GH20H035765 1.8 FANTOM5 ENCODE dbSUPER 10.5 +70.3 70274 9 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF548 SP3 NFYC SSRP1 CPNE1 RBM12 RBM39 NCOA6 ERGIC3 PHF20 AAR2 DLGAP4-AS1 TRPC4AP PROCR
GH20H035791 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +93.1 93141 1 SOX6 ATM GATA3 JUND ZNF366 POLR2A RCOR2 ADNP IKZF1 NBN CPNE1 PHF20 RBM39 RPF2P1 NFS1 ROMO1 SPAG4 GC20M035824
GH20H035659 1.4 ENCODE dbSUPER 11.5 -36.4 -36440 5 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CPNE1 RBM39 RBM12 EIF6 ERGIC3 ROMO1 NFS1 TRPC4AP GGT7 PHF20
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ROMO1 on UCSC Golden Path with GeneCards custom track

Promoters for ROMO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136590 228 1801 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for ROMO1 Gene

Chromosome:
20
Start:
35,699,272 bp from pter
End:
35,700,984 bp from pter
Size:
1,713 bases
Orientation:
Plus strand

Genomic View for ROMO1 Gene

Genes around ROMO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ROMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ROMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROMO1 Gene

Proteins for ROMO1 Gene

  • Protein details for ROMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60602-ROMO1_HUMAN
    Recommended name:
    Reactive oxygen species modulator 1
    Protein Accession:
    P60602
    Secondary Accessions:
    • A7M872
    • E1P5R9
    • E9KL28
    • Q3MHD5
    • Q5QP16
    • Q9CQ98
    • Q9H1N2

    Protein attributes for ROMO1 Gene

    Size:
    79 amino acids
    Molecular mass:
    8183 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Enforced expression in IMR-90 cells leads to increased levels of ROS and induces premature cell senescence and nuclear DNA damage.

    Alternative splice isoforms for ROMO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ROMO1 Gene

Post-translational modifications for ROMO1 Gene

No Post-translational modifications

Other Protein References for ROMO1 Gene

No data available for DME Specific Peptides for ROMO1 Gene

Domains & Families for ROMO1 Gene

Gene Families for ROMO1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for ROMO1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ROMO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60602

UniProtKB/Swiss-Prot:

ROMO1_HUMAN :
  • Belongs to the MGR2 family.
Family:
  • Belongs to the MGR2 family.
genes like me logo Genes that share domains with ROMO1: view

Function for ROMO1 Gene

Molecular function for ROMO1 Gene

UniProtKB/Swiss-Prot Function:
Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
UniProtKB/Swiss-Prot Function:
Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
UniProtKB/Swiss-Prot Induction:
By the anticancer drug fluorouracil (5FU).

Gene Ontology (GO) - Molecular Function for ROMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with ROMO1: view

Phenotypes for ROMO1 Gene

genes like me logo Genes that share phenotypes with ROMO1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ROMO1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ROMO1 Gene

Localization for ROMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ROMO1 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ROMO1 gene
Compartment Confidence
mitochondrion 5
extracellular 3

Gene Ontology (GO) - Cellular Components for ROMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA 16842742
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ROMO1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ROMO1 Gene

Pathways & Interactions for ROMO1 Gene

SuperPathways for ROMO1 Gene

No Data Available

Interacting Proteins for ROMO1 Gene

Gene Ontology (GO) - Biological Process for ROMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001302 replicative cell aging IMP 18836179
GO:0008284 positive regulation of cell proliferation IDA 18313394
GO:0031640 killing of cells of other organism IMP 22083756
GO:0034614 cellular response to reactive oxygen species IMP 18836179
GO:0042742 defense response to bacterium IDA,IEA 22083756
genes like me logo Genes that share ontologies with ROMO1: view

No data available for Pathways by source and SIGNOR curated interactions for ROMO1 Gene

Drugs & Compounds for ROMO1 Gene

No Compound Related Data Available

Transcripts for ROMO1 Gene

Unigene Clusters for ROMO1 Gene

Reactive oxygen species modulator 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ROMO1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ROMO1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: -
SP3:

Relevant External Links for ROMO1 Gene

GeneLoc Exon Structure for
ROMO1
ECgene alternative splicing isoforms for
ROMO1

Expression for ROMO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ROMO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ROMO1 Gene

This gene is overexpressed in Retina (11.0), Testis (10.3), Pancreas (9.6), and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ROMO1 Gene



Protein tissue co-expression partners for ROMO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ROMO1 Gene:

ROMO1

SOURCE GeneReport for Unigene cluster for ROMO1 Gene:

Hs.472564

mRNA Expression by UniProt/SwissProt for ROMO1 Gene:

P60602-ROMO1_HUMAN
Tissue specificity: Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line. Highly expressed in brain tumors.

Evidence on tissue expression from TISSUES for ROMO1 Gene

  • Nervous system(4.5)
  • Bone marrow(4.3)
  • Muscle(2.6)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with ROMO1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ROMO1 Gene

Orthologs for ROMO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ROMO1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia ROMO1 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ROMO1 33 34
  • 99.16 (n)
cow
(Bos Taurus)
Mammalia ROMO1 33 34
  • 95.78 (n)
dog
(Canis familiaris)
Mammalia ROMO1 33 34
  • 94.09 (n)
mouse
(Mus musculus)
Mammalia Romo1 33 16 34
  • 93.25 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910944 33
  • 92.41 (n)
chicken
(Gallus gallus)
Aves ROMO1 34 34
  • 96 (a)
OneToMany
LOC100858376 33
  • 83.54 (n)
lizard
(Anolis carolinensis)
Reptilia ROMO1 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia romo1 33
  • 80.59 (n)
zebrafish
(Danio rerio)
Actinopterygii ROMO1 34
  • 89 (a)
OneToOne
zgc:73345 33
  • 79.75 (n)
zgc73345 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9814 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012145 33
  • 72.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6878 33 34
  • 65.4 (n)
worm
(Caenorhabditis elegans)
Secernentea rmo-1 34
  • 49 (a)
OneToMany
Y94A7B.11 34
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MGR2 36 36
Species where no ortholog for ROMO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ROMO1 Gene

ENSEMBL:
Gene Tree for ROMO1 (if available)
TreeFam:
Gene Tree for ROMO1 (if available)

Paralogs for ROMO1 Gene

Pseudogenes.org Pseudogenes for ROMO1 Gene

genes like me logo Genes that share paralogs with ROMO1: view

No data available for Paralogs for ROMO1 Gene

Variants for ROMO1 Gene

Sequence variations from dbSNP and Humsavar for ROMO1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1001969293 -- 35,700,133(+) CTAGT(C/T)ACTAC intron-variant, upstream-variant-2KB
rs1002621101 -- 35,699,436(+) GCGAC(C/G)CAGCC upstream-variant-2KB, utr-variant-5-prime
rs1002673199 -- 35,699,272(+) TCCAA(G/T)CGGCT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1003686803 -- 35,700,597(+) CATCC(A/G)CCAGA intron-variant, upstream-variant-2KB
rs1003896019 -- 35,698,794(+) CTGGA(C/G)GGGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ROMO1 Gene

Variant ID Type Subtype PubMed ID
nsv526188 CNV gain 19592680

Variation tolerance for ROMO1 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ROMO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ROMO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROMO1 Gene

Disorders for ROMO1 Gene

Relevant External Links for ROMO1

Genetic Association Database (GAD)
ROMO1
Human Genome Epidemiology (HuGE) Navigator
ROMO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ROMO1

No disorders were found for ROMO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ROMO1 Gene

Publications for ROMO1 Gene

  1. A critical role for Romo1-derived ROS in cell proliferation. (PMID: 18313394) Na AR … Yoo YD (Biochemical and biophysical research communications 2008) 2 3 4 60
  2. Drug resistance to 5-FU linked to reactive oxygen species modulator 1. (PMID: 17537404) Hwang IT … Yoo YD (Biochemical and biophysical research communications 2007) 2 3 4 60
  3. A novel protein, Romo1, induces ROS production in the mitochondria. (PMID: 16842742) Chung YM … Yoo YD (Biochemical and biophysical research communications 2006) 2 3 4 60
  4. Antibacterial potential of hGlyrichin encoded by a human gene. (PMID: 22083756) Sha J … Wang Z (Journal of peptide science : an official publication of the European Peptide Society 2012) 3 4 60
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60

Products for ROMO1 Gene

Sources for ROMO1 Gene

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